Khalid Al-Nedawi, PhD


Assistant Professor
Department of Medicine
McMaster University and St. Joseph’s Healthcare
50 Charlton Street East
Hamilton, Ontario, Canada

Biography

Dr. Al-Nedawi received his PhD in Medical Biology and Biotechnology. He received a post-doctoral fellowship and scientific adjunct position at the center for medical research at the Polish Academy of Science. He joined McGill University as a post-doctoral fellow and later as medical scientist and faculty lecturer. Dr. Al-Nedawi has received several awards and recognition for his scientific accomplishments. He is the winner of the 2010 Michael G. DeGroote academic fellowship award at McMaster University. Currently, Dr Al-Nedawi is an Assistant Professor at McMaster University/Department of Medicine.

RESEARCH:

Dr. Al-Nedawi has contributed to research on thrombosis haemostasis, cancer progression, angiogenesis, metastasis and biomarkers. Dr. Al-Nedawi’s primary interest is the mechanisms of intercellular interactions through short exosomes / microvesicles. Dr. Al-Nedawi reported the mechanism by which cancer cells can shed oncogenic proteins via microvesicles to the neighboring non-cancer cells providing them with an ectopic transformed phenotype. Furthermore, he reported the transfer of oncogenic proteins from cancer cells to tumour endothelial cells triggering the angiogenic switch. In addition, he contributed to the detection of oncogenic proteins in the cargo of microvesicles circulating in the cancer patient’s peripheral blood. Dr. Al-Nedawi has published in high ranked medical journals like “Blood, ATVB, NCB, PNAS”, and contributed to many international scientific conferences. Dr Al-Nedawi is funded by prostate cancer Canada (Movember foundation), and St Joseph’s Hospital. Dr Al-Nedawi lab located at St Joseph’s healthcare, Hamilton Center for Kidney Research. A postdoctoral fellow and four graduate students, currently working in Dr Al-Nedawi’s lab pursuing different research projects.

Research Interest

His research interests include: Microvesicles/exosomes as source of biomarkers, Intercellular communication through microvesicles and short peptides, Signal Transduction, Biology of Cancer and cellular transformation, Angiogenesis, Transgenic mouse and stem Cell biology, Thrombosis – Haemostasis

Scientific Activities

AWARDS AND HONORS

• (2010) Michael DeGroote Academic Fellow, McMaster University

Publications

1. Al-Nedawi K. The yin-yang of microvesicles (exosomes) in cancer biology. Frontiers in Oncology. 2014; 4: 172. doi:10.3389/fonc.2014.00172
2. Kathleen Gabriel, Alistair Ingram, Austin R, et al. Regulation of the tumor suppressor PTEN through exosomes: A diagnostic potential for prostate cancer. PLOS One. 2013; 8, 7: e70047. doi:10.1371/journal.pone.0070047
3. Al-Nedawi K, Meehan B, Micaleff J, Lahotak W, Guha Ab, Rak J. Intercellular Transfer of the Oncogenic EGFRvIII via Tumor Cell Derived Microvesicles. Nature Cell Biology. 2008; 10(5): 619-624. doi:10.1038/ncb1725.
4. Al-Nedawi K, Meehan B, Kerbel R, Anthony C. Allison, Rak J. Endothelial expression of autocrine VEGF upon the uptake of tumor-Derived microvesicles containing oncogenic EGFR. Proc Natl Acad Sci U S A (PNAS). 2009; 106(10): 3794-3799. doi:10.1073/pnas.0804543106
5. Al-Nedawi K, Meehan B, Rak J. Microvesicles- messengers and mediators of tumor progression. Cell Cycle. 2009; 8(13):2014-2018. doi:10.4161/cc.8.13.8988
6. Lee TH, D’Asti A, Magnus N, Al-Nedawi K, Meehan B, Rak J. Microvesicles as mediators of intercellular communication in cancer the emerging science of cellular ‘debris’. Semin Immunopathol. 2011; 33(5):455-467. doi:10.1007/s00281-011-0250-3
7. Milsom C, Magnus N, Meehan B, Al-Nedawi K, Garnier D, Rak J. Tissue Factor and Cancer Stem Cells- Is there a Linkage? Arteriosclerosis Thrombosis and Vascular Biology. 2009; 29(12): 2005-2014. doi:10.1161/ATVBAHA.108.177444
8. Al-Nedawi K, Szemraj J, Cierniewski CS. Mast cell-derived exosomesactivate endothelial cells to secrete plasminogen activator inhibitor type 1. Arteriosclerosis Thrombosis and Vascular Biology. 2005; 25(8): 1744-1749. doi: 10.1161/01.ATV.0000172007.86541.76
9. Al-Nedawi K, Czyz M, Bednarek M, et al. Thymosin β4 Induces the SynthesisOf Plasminogen Activator Inhibitor-1 in Cultured Endothelial Cells and Increases ItsExtracellular Expression. Blood. 2004; 103(4):1319-1324. doi:10.1182/blood-2003-04-1015.
10. Milsom C, Yu J, May L, et al. The Role of Tumor and Host-Related Tissue Factor Pools in Oncogene-Driven Tumor Progression. Thrombosis Research. 2007; 120(2): 82-91. doi:http://dx.doi.org/10.1016/S0049-3848(07)70135-4
11. Ullerås E, Trzaska D, Arkusz J, et al. Development of the “Cell Chip”: A New In-Vitro AlternativeTechnique for Immunotoxicity Testing. Toxicology. 2005; 206(2):245-256. doi:10.1016/j.tox.2004.08.016
12. Szemraj J, Al-Nedawi K, Pawlowska Z, Chabielska E, Buciko W. Tissue Distribution of Phosphorothioate Oligodeoxyribonucleotides Antisense to PAI-1 mRNA in Rats. Acta Biochimica Polonica. 2005; 52 (4):849-855 .
13. Swiatkowska M, Szemraj J, Al-Nedawi K, Pawlowska Z. Reactive Oxygen Species upregulate expression of PAI-1 in endothelial cells. Cellular and Molecular BiologyLetters. 2002; 7(4): 1065-1071.
14. Al-Nedawi K, Pawlowska Z, Cierniewski CS. Interferon-gamma bound to endothelial cells is phosphorylated by ecto-protein kinases. Acta Biochimica Polonica. 1999; 46(3): 693-702.