Kamal A. Mohammed, PhD


Associate Professor
Division of Pulmonary Critical Care and Sleep Medicine
Department of Medicine
University of Florida and Chair, Subcommittee for Research Safety
North Florida/South Georgia Veterans Health System
Malcom Randall VA Medical Center
Gainesville, FL-32608, USA

Biography

Education:

• (1993): PhD in Immunology from Osmania University, INDIA. PhD. Thesis title: Immunomodulatory effects of Plumbagin (5-Hydroxy- 2- Methyl-1, 4- naphthoquinone) in BALB/c mice
• (1986): MS (Zoology), First Division with top 3% at Osmania University, INDIA
• (1984): BS (Biology, Applied Nutrition & Public Health), First Division with distinction, Osmania University, INDIA

Research & Development-Subcommittees

• (2004-Present): Chair, Subcommittee for Research Safety, North Florida/South Georgia Veterans Health Care System, Malcom Randall VAMC, Gainesville, FL
• (2005-Present): Research and Development Committee, North Florida/South Georgia Veterans Health Care System, Malcom Randall VAMC, Gainesville, FL
• (2004-Present): Institutional Animal Care and Use Committee (IACUC) North Florida/South Georgia Veterans Health Care System, Malcom Randall VAMC, Gainesville, FL
• (2008-Present): Scientific grants review (Reorganization) committee, North Florida/South Georgia Veterans Health Care System, Malcom Randall VA Medical Center, Gainesville, FL
• 2008-Present): Research Space Utilization Committee, North Florida/South Georgia Veterans Health Care System, Malcom Randall VA Medical Center, Gainesville, FL
• (2006-Present): Research Task Force Division of Pulmonary Critical Care and Sleep Medicine, University of Florida, Gainesville, FL
• (2006-Present): Research Advisory Committee MD-PEDS-Critical Care Division, University of Florida, Gainesville, FL
• (2003-2004): Subcommittee for Research Safety, North Florida/South Georgia Veterans Health Care System, Malcom Randall VA Medical Center, Gainesville, FL
• (2002-2003): Subcommittee for Radiation Safety, Veterans Administration Medical center, Indianapolis, IN
• (2001-2003): Subcommittee for Research Bio-safety, Veterans Administration Medical center, Indianapolis, IN

Teaching Experience:

• (2013-Present): Mechanisms of Innate Immune Defenses in MRSA induced Pleural Empyema. Satindra Gehlot, PhD, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Florida, Gainesville, FL
• (2009-Present): Receptor Tyrosine Kinase Signaling in Thoracic Malignancies. Hun-Yen Lee, PhD, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Florida, Gainesville, FL
• (2010-2013): Significance of MicroRNA signaling in Pleural Mesothelial Cell Epithelial Mesenchymal Transition. Bhagayalaxmi Sukka-Ganesh, PhD, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Florida, Gainesville, FL
• (2010-2012): Role of EphA2 signaling and MCL-1 in Malignant Pleural Mesothelioma. Nazli Khodayari, PhD, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Florida, Gainesville, FL
• (2009-2010): Significance of SOCS3 signaling in Airway Inflammation. Lixandra Gonzalez, BS, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Florida, Gainesville, FL
• (2006-2008): TLR-2 signaling in pleural mesothelial innate immune defenses in Staphylococcal infection. Tajamul Hussain, PhD, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Florida, Gainesville, FL
• (2006-2008): Veterinary Immunology course (VEM5110B). College of Veterinary Medicine, University of Florida, Gainesville, FL
• (2006-2007): Role of Cylcin D1 in Cyclical Stretch Induced Bronchial Smooth Muscle Cell Proliferation. (PhD), Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Florida, Gainesville, FL
• (2003-2006): Significance of Hemoxygenase-1 signaling in Mycobacterium avium infection. Yimu Lai, PhD, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Florida, Gainesville, FL
• (2002): Role of the focal adhesion protein Paxillin in pleural permeability. Research project: Carlos Ramirez-Icaza, M.D. Fellow in Pulmonary and Critical Care Medicine, VA Medical Center, Indiana University
• (2002): Mechanisms of RSV mediated permeability changes in bronchial airway epithelial cells. Research project: Muna Kilani, MD. Fellow in Pediatric Pulmonary and Critical Care Medicine, VA Medical Center, Indiana University
• (2002): Defensive role of pleural mesothelial cell sialomucin in pleural metastasis. Research project. Ramit K. Sharma, MD. Fellow in Pulmonary and Critical Care Medicine, VA Medical Center, Indiana University
• (2001): Repair Mechanisms In Bronchial Epithelial Monolayer: Role Of CCR2 Receptor. Research project: Matthew Lundien, M.D. Fellow in Pulmonary and Critical Care Medicine, VA Medical Center, Indiana University
• (2001): Metastatic Ovarian Cancer Increases Pleural Permeability. Research project : Shriram P.S., M.D. Fellow in Pulmonary Critical Care Medicine, VA Medical Center, Indiana University
• (2000): Human Pleural Fibroblast Expression of C-C (Monocyte Chemotactic Peptide) and C-X-C (Interleukin 8) Chemokines. Research project : Farzad Loghmani, M.D. Fellow in pulmonary Critical Care Medicine, VA Medical Center, Indiana University
• (1999): Low but not high molecular weight hyaluronan induces chemotactic response in human malignant mesothelioma. Research project: Hasmeena Kathuria, M.D., Fellow in Pulmonary and Critical Care Medicine, VA Medical Center, Indiana University
• (1998): Staphylococcus aureus mediates Murine KC and MIP-2 expression in Pleural Mesothelial cells. Research Project: Nikia S Brown, B.S. Graduate summer trainee, VA Medical Center, Indiana University
• (1996): Effect of Mesothelial cells on Neutrophil Apoptosis in Pleural Space. Research Project: John B. Harness, B.S. Graduate summer trainee, VA Medical Center, Indiana University
• (1996): Regulation of MIP-1 Expression in Mesothelial cells. Research Project : Kelli E. Daniels, B.S. Graduate summer trainee, VA Medical Center, Indiana University
• (1993-1994): Teaching Immunology and Biochemistry to masters graduate students at Osmania University – Nizam’s College, INDIA

Research Experience:

• (2003-Present): Research Health Scientist, (a 5/8 appointment) North Florida/South Georgia Veterans Health Care System, Malcom Randall VAMC, University of Florida, Gainesville, FL
• (Jan 2010-Present). Research Associate Professor, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Florida, Gainesville, FL
• (Nov 2003-Dec 2009). Assistant Professor, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Florida, Gainesville, FL
• (2000-2003): Research Health Scientist, (a 5/8 appointment) Roudebush VAMC, Indianapolis, Indiana University Medical Center, Indianapolis, IN
• (1999-2003): Assistant Scientist, Division of Pulmonary, Critical Care & Occupational Medicine, Indiana University School of Medicine, VA Medical Center, IUPUI, Indianapolis, IN, USA
• (1997-1999): Research Associate (WOC appointment at VA Medical Center), Division of Pulmonary, Critical Care & Occupational Medicine, Indiana University School of Medicine, VA Medical Center, IUPUI, Indianapolis, IN, USA
• (1995-1997): Post Doctoral Fellow (WOC appointment at VA Medical Center), Division of Pulmonary, Critical Care & Occupational Medicine, Indiana University School of Medicine, VA Medical Center, IUPUI, Indianapolis, IN, USA
• (1994-1995): Post Doctoral Fellow, Center for Cellular & Molecular Biology, Hyderabad, INDIA
• 1994-1994): Research Associate, Institute of Microbial Technology, Chandigarh, INDIA
• (1990-1993): Senior Research Fellow, (NET) Osmania University, Hyderabad, INDIA
• (1987-1990): Junior Research Fellow, (NET) Osmania University, Hyderabad, INDIA

Research Interest

His research interests include: Mechanisms of lung injury in Chronic Obstructive Pulmonary Disease, Pneumonia, and pleural fibrosis. Mechanisms of Toll-like receptor signaling in lung infections and micro-RNA signaling in lung inflammation/injury. Mechanisms of epithelial barrier functions, and cellular traffic in lung infection/injury.

Scientific Activities

Workshops & Courses:
1. IUIS – WHO Advanced Course on Basic Immunology organized by the International Union of Immunology and All India Institute of Medical Sciences (AIIMS), New Delhi, INDIA. November 1993.
2. Training in Interferon Bio-Assays at National Institute of Virology (A WHO Collaborating Center for Arbovirus Reference and Research), Pune, INDIA. February 1991.
3. IUIS – WHO Advanced Immunology Course (Focus on the immunology of infectious diseases) organized by the International Union of Immunology Society, World Health Organization, and All India Institute of Medical Sciences (AIIMS), New Delhi, INDIA. November 1989.
4. Molecular Biology course Indiana University School of Medicine. IUPUI, Indianapolis, IN. June 8-25, 1998.
5. Radiation-Safety course Indiana University School of Medicine. IUPUI, Indianapolis, IN. June 8-25, 1997.

Membership in Scientific Societies:
1. Member of American Federation for Medical Research.
2. Member of American Thoracic Society.
3. Member of American Society for Pharmacology and Experimental Therapeutics.
4. Member of Indiana Thoracic Society, The Medical Section of the American Lung Association of Indiana.

Invited Seminars
1. Mohammed, KA. “Significance of miR-26 in Pleural Empyema” presented at the Division of Pulmonary, Critical Care & Sleep Medicine, University of Florida, (2012).
2. Mohammed, KA. “Experimental Models in Lung Diseases” presented at the Work Shop on Research and Development, Kakatiya University, India; (July 2011).
3. Mohammed, KA. “Tuberculosis: Infection, Control and Prevention” presented at the Government Pingle PG College, Kakatiya University, India; (July 2011).
4. Mohammed, KA. “Significance of Hemeoxygenase-1in Pleural Fibrosis” presented at the Department of Medicine Retreat, University of Florida, (2011).
5. Mohammed, KA. “Role of Hemeoxygenase-1 in Pleural Mesothelial Cell Epithelial Mesenchymal Transition” presented at the Division of Pulmonary, Critical Care & Sleep Medicine, University of Florida, (2011).
6. Mohammed, KA. “Mechanisms of Pleural Fibrosis in Empyema” presented at the Division of Pulmonary, Critical Care & Sleep Medicine, University of Florida, (2010).
7. Mohammed, KA. “Beta-defensins in pleural infections” presented at the Division of Pulmonary, Critical Care & Sleep Medicine, University of Florida, (2009).
8. Mohammed, KA. “Heme Oxygenase-1 in TB Pleurisy” presented at the Division of Pulmonary, Critical Care & Sleep Medicine, University of Florida, (2008).
9. Mohammed, KA. “Innate Immunity: Significance in Pleural Infection” presented at the Division of Pulmonary, Critical Care & Sleep Medicine, University of Florida, (2007).
10. Mohammed, KA. “Inflamed Pleura: Innate Immune Responses of the Pleural Mesothelium” presented at the Division of Pulmonary, Critical Care & Sleep Medicine, University of Florida, (2007).
11. Mohammed, KA. Pleural Mesothelial Cells and Pleural Effusions” presented at the Veterinary College of Medicine, University of Florida, (2006).
12. Mohammed, KA. “Mechanical Forces in Lung Remodeling” presented at the Division of Pulmonary, Critical Care & Sleep Medicine, University of Florida, (2006).
13. Mohammed, KA. “Allergen Induced Asthma” presented at the Division of Pulmonary, Critical Care & Sleep Medicine, University of Florida, (2005).
14. Mohammed, KA. “Role Pleural Mesothelial Toll-like receptors in Empyema” presented at the Division of Pulmonary, Critical Care & Sleep Medicine, University of Florida, (2004).
15. Mohammed, KA. “Pleural Mesothelial Cells Bridging Innate and Adaptive Immune responses in Pleura” presented at the Division of Pulmonary, Critical Care & Occupational Medicine, Indiana University Medical Center, Indiana, (2003).
16. Mohammed, KA. “Pleural Infection and Mesothelial Barrier Dysfunction” presented at the Division of Pulmonary, Critical Care & Occupational Medicine, Indiana University Medical Center, Indiana, (2002).

Publications

1. Mohammed KA, Rao PR. Modulatory effect of Plumbagin (5- Hydroxy- 2- Methyl-1, 4-naphthoquinone) on Macrophage Functions in BALB/c mice I. I. Potentiation of Macrophage Bactericidal Activity. Immunopharmacology. 1995; 30(3): 231-236. doi: 10.1016/0162-3109(95)00027-Q
2. Ashok Khar KA, Usalya S, Mohammed KA. AK-5 tumor induced modulation of host immune function: Up-regulation of Th1 type Cytokine Response Mediates early Tumor Regression. Cytokines and Molecular Therapy. 1996; 2: 39-46.
3. Mohammed KA, Nasreen N, Ward MJ, Antony VB. Macrophage Inflammatory Protein-1a: A C-C Chemokine in Parapneumonic Pleural Effusions. J Lab Clin Med. 1998; 132(3): 202-209.
4. Mohammed KA, Nasreen N, Ward MJ, Panadero FR, Antony VB. Mycobacterium Mediated Chemokine Expression in Pleural Mesothelial Cells: Role of C-C Chemokines in Tuberculous Pleurisy. J Infec Dis. 1998; 178: 1450-1456. doi: 10.1086/314442
5. Nasreen N, Hartman DL, Mohammed KA, Antony VB. Talc Induces Pleural Mesothelial cell Expression of Proinflammatory Cytokines and Intercellular Adhesion Molecule-1 (ICAM-1). Am J Respir Crit Care Med. 1998; 158: 971-978.
6. Mohammed KA, Nasreen N, Ward MJ, Antony VB. Helper T-cell type 1 and 2 Cytokines Regulate C-C Chemokine Expression in Mesothelial Cells. Am J Respir Crit Care Med. 1999; 159: 1653-1659. doi: 10.1164/ajrccm.159.5.9810011
7. Nasreen N, Mohammed KA, Ward MJ, Antony VB. Mycobacterium-induced transmesothelial migration of monocytes into pleural space: role of intercellular adhesion molecule-1 in tuberculous pleurisy. J Infec Dis. 1999; 180(5): 1616-1623. doi: 10.1086/315057
8. Galffy G, Mohammed KA, Nasreen N, Ward MJ, Antony VB. Inhibition of interleukin-8 Reduces Malignant Pleural Mesothelioma Propagation in Nude Mouse Model. Interntl J Oncol Res. 1999; 11(4): 187-194.
9. Galffy G, Mohammed KA, Ward MJ, Dowling PA, Nasreen N, Antony VB. Interleukin-8, an Autocrine Growth Factor for Malignant Mesothelioma. Cancer Research. 1999; 59: 367-371.
10. Nasreen N, Mohammed KA, Dowling PA, Ward MJ, Antony VB. Talc Induces Apoptosis in Human Malignant Mesothelioma in vitro. Am J Respir Crit Care Med. 2000; 161(2(1)): 595-600. doi: 10.1164/ajrccm.161.2.9904123
11. Mohammed KA, Nasreen N, Ward MJ, Antony VB. Induction of Acute Pleural Inflammation by Staphylococcus aureus: I. CD4+ T cells Play a Critical Role in Experimental Empyema. J Infec Dis. 2000; 181(5): 1693-1699. doi: 10.1086/315422
12. Nasreen N, Mohammed KA, Ward MJ, Antony VB. MCP-1 in pleural injury: CCR2 mediates haptotaxis of pleural mesothelial cells. Am J Physiol – Lung Cellu Mol Physiol. 2000; 278(3): L591-L598.
13. Mohammed KA, Nasreen N, Hardwick J, et al. Antony. Bacterial Induction of Pleural Mesothelial Monolayer Barrier Dysfunction. Am J Physiol – Lung Cell Mol Physiol. 2001; 281: L119-L125.
14. Nasreen N, Mohammed KA, Hardwick J, et al. Polar Production of IL-8 By Mesothelial Cells Promotes The Transmesothelial Migration of Neutrophils: Role of ICAM-1. J Infec Dis. 2001; 183(11): 1638-1645. doi: 10.1086/320700
15. Loghmani F, Mohammed KA, Nasreen N, et al. Cytokines Mediate C-C (Monocyte Chemotactic Peptide) and C-X-C (Interleukin 8) Chemokine Expression in Human Pleural Fibroblasts. Inflammation. 2002; 26(2): 73-82.
16. Lundien MC, Mohammed KA, Nasreen N, et al. Induction of MCP-1 Expression in Airway Epithelial Cells : Role of CCR2 Receptor in Airway Epithelial Injury. J Clin Immunol. 2002; 22(3): 144-152.
17. Ajay B, Robert S, Mohammed KA. Cockroach Extract Allergen Induces Permeability Change in Human Bronchial Airway Epithelial Cells. J Allergy Clin Immunol. 2002; 110(4): 589-595.
18. Nasreen N, Mohammed KA, Sanders KL, et al. Staphylococcus aureus Stimulated Pleural Mesothelial Cells (PMC) Modulate Polymorphnuclear Leukocyte (PMN) Apoptosis. J Clin Immunol. 2003; 23(1): 1-10.
19. Nasreen N, Mohammed KA, Hardwick J, et al. Low molecular weight hyaluronan induces malignant mesothelioma cell (MMC) proliferation and haptotaxis: Role of CD44 receptor in MMC proliferation and haptotaxis. Oncology Research. 2002; 13(2): 71-78. doi: http://dx.doi.org/10.3727/096504002108748105
20. Shriram PS, Mohammed KA, Nasreen N, et al. Metastatic Ovarian Cancer Increases Pleural Permeability. Oncology Research. 2002; 13(2): 79-85.
21. Mohammed KA, Nasreen N, Hardwick J, et al. Mycobacteria Induces Pleural Mesothelial Permeability by down-regulating beta-catenin Expression. Lung. 2003; 181(2): 57-66. doi: 10.1007/s00408-003-1006-1
22. Sharma RK, Mohammed KA, Nasreen N, et al. Carlos Ramirez-Icaza, Antony VB. Defensive role of Pleural Mesothelial Cell (PMC) Sialomucins in Tumor Metastasis. Chest. 2003; 124(2): 682-687.
23. Icaza GR, Mohammed KA, Nasreen N, et al. Th2 Cytokines IL-4 and IL-13 Down Regulate Paxillin Expression in Bronchial Airway Epithelial Cells. J Clin Immunol. 2004; 24(4): 426-434.
24. Kilani MM, Mohammed KA, Nasreen N, Hardwick JA, Tepper RS, Antony VB. Respiratory Syncytial Virus Causes Increased Bronchial Epithelial Permeability. Chest.2004; 126(1): 186-191. doi: 10.1378/chest.126.1.186
25. Antony VB, Nasreen N, Mohammed KA, et al. Talc Pleurodesis: Pleural fluid bFGF mediates pleural fibrosis. Chest. 2004; 126(5): 1522-1528. doi: 10.1378/chest.126.5.1522
26. Kilani MM, Mohammed KA, Nasreen N, Tepper RS, Antony VB. RSV causes HIF-1alpha stabilization via NO release in primary bronchial epithelial cells. Inflammation. 2004; 28(5): 245-251. doi: 10.1007/s10753-004-6047-y
27. Nasreen N, Mohammed KA, Sanders KL, et al. Pleural Mesothelial cell (PMC) defense mechanisms against malignancy. Oncol Res An Internatl J. 2004; 14(3): 155-161. doi: 10.3727/000000003771013053
28. Nasreen N, Mohammed KA, Antony VB. Silencing the receptor EphA2 suppresses the growth and haptotaxis of malignant mesothelioma cells. Cancer. 2006; 15(107(10)): 2425-2435. doi: 10.1002/cncr.22254
29. Nasreen N, Mohammed KA, Brown S, et al. Tal mediates angiostasis in malignant pleural effusions via endostatin induction in Pleural Mesothelial. Eur Respir J. 2007; 29(4): 761-769. doi: 10.1183/09031936.00061606
30. Nasreen N, Mohammed KA, Hussain T, Antony VB. Receptor EphA2 activation with EphrinA1 Suppresses Growth of Malignant Mesothelioma. Cancer Letters. 2007; 18: 258(2): 215-222. doi: 10.1016/j.canlet.2007.09.005
31. Mohammed KA, Nasreen N, Antony VB. Staphylococcus aureus Induces Differential Expression of C-fos, C-jun and Mediates Apoptosis in Pleural Mesothelial Cells. Lung. 2007; 185(6): 355-365.
32. Mohammed KA, Nasreen N, Tepper RS, Veena B. Antony. Inhibition of P44/42 MAPK Ameliorates Cyclical Stretch induced PlGF release in Bronchial Airway Epithelial Cells. Am J Physiol Lung Cell Mol Physiol. 2007; 292(2): L559-L566.
33. Brown SC, Mohammed KA, Sharma P, Nasreen N, Anthony VB, Moudgil BM. “Influence of Shape, Adhesion and Simulated Lung Mechanics on Amorphous Silica Nanoparticle Toxicity. Advanced Powder Technology. 2007; 18(1): 69-79. doi: 10.1163/156855207779768214
34. Lai YM, Mohammed KA, Nasreen N, Baumuratov A, Bellew BF, Antony VB. Induction of cell cycle arrest and apoptosis by BCG infection in cultured human bronchial airway epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2007; 293(2): L393-L401. doi: 10.1152/ajplung.00392.2006
35. Hussain T, Nasreen, N, Lai Y, Bellew BF, Antony VB, Mohammed KA. Innate Immune Responses in Murine Pleural Mesothelial Cells: TLR2 Dependent Induction of -defensin-2 by Staphylococcal Peptidoglycan. Am J Physiol Cell and Mol Physiol. 2008; 295(3): L461-L470. doi: 10.1152/ajplung.00276.2007
36. Nasreen N, Mohammed KA, Mubarak KK, et al. Pleural mesothelial cell transformation into myofibroblasts and haptotactic migration in response to TGF-1 in vitro. Am J Physiol Cell and Mol Physiol. 2009; 297(1): L115-L124. doi: 10.1152/ajplung.90587.2008
37. Han W, Wang W, Mohammed KA, Su Y. α-Defensins increase lung fibroblast proliferation and collagen synthesis via Wnt/Beta-Catenin pathway. EMBO J. 2009; 276(22): 6603-6614. doi: 10.1111/j.1742-4658.2009.07370.x
38. Montes-Worboys A, Brown S, Regev D, et al. Targeted delivery of amiKA, cin into granuloma. Am J Respir Crit Care Med. 2010; 15(182(12)): 1546-1553. doi: 10.1164/rccm.200912-1888OC
39. Mohammed KA, Wang X, Antony VB, Nasreen N. Silencing receptor EphA2 Induces Apoptosis and attenuate tumor growth in Malignant Mesothelioma. Am J Cancer Research. 2011; 1(3): 419-431.
40. Lee H, Mohammed KA, Goldberg EP, Nasreen N. Targeted lung cancer therapy using ephrinA1-loaded albumin microspheres. J Pharm Pharmacol. 2011; 63(11): 1401-1410. doi: 10.1111/j.2042-7158.2011.01306.x
41. Khodayari N, Mohammed KA, Goldberg EP, Antony VB, Nasreen N. EphrinA1Inhibits Malignant Mesothelioma tumor growth via let-7 microRNA mediated repression of the RAS oncogene. Cancer Gene Therapy. 2011; 18(11): 806-816. doi: 10.1038/cgt.2011.50
42. Nasreen N, Khodayari N, Sukka B, et al . Fluticasone Propionate and Salmeterol Combination Induces SOCS-3 Expression in Airway Epithelial Cells. International Journal of Immuno-pharmacology. 2012; 12(1): 217-225. doi: 10.1016/j.intimp.2011.11.014
43. Mubarak KK, Worboys AM, Regev D, et al. Parenchymal trafficking of pleural mesothelial cells in idiopathic pulmonary fibrosis: Potential role in pathogenesis. Eur Respir J. 2012; 39(1): 133-140.
44. Nasreen N, Khodayari N, Mohammed KA. Advances in Malignant Pleural Mesothelioma therapy: Targeting EphA2 a Novel Approach. Am J Cancer Research. 2012; 2(2): 222-234.
45. Sukka -Ganesh B, Mohammed KA, Ye F, Goldberg EP, Nasreen N. Ephrin-A1 Inhibits NSCLC Tumor Growth via Induction of Cdx-2 a Tumor Suppressor GeneBMC. Cancer. 2012 ; 12(1): 309. doi: 10.1186/1471-2407-12-309
46. Lee HY, Mohammed KA, Goldberg EP, Nasreen N. Arginine-conjugated Albumin Microspheres inhibits Proliferation and Migration in Lung Cancer Cells. Am J Cancer Research. 2013; 3(3): 2156-6976.
47. Lee HY, Mohammed KA, Sharma P, Moudgil BM, William CL, Nasreen N. Targeted delivery of let-7a microRNA encapsulated ephrin-A1 conjugated liposomal nanoparticles inhibit tumor growth in lung cancer. International Journal of Nano-medicine. 2013; 8: 4481-4494. doi: 10.2147/IJN.S41782
48. Lee HY, Mohammed KA, Ye F, et al. Targeted Delivery of Let-7a MicroRNA Encapsulated-EphrinA1 Conjugated Liposomal Nanoparticles Inhibit Tumor Growth in Lung Cancer. Intl. Journal of Nano medicine. 2013; 8: 4481-4494. doi: 10.2147/IJN.S41782
49. Nasreen N, Gonzalves L, Sriram PS, Mohammed KA. Fluticasone furoate is more effective than mometasone furoate in restoring tobacco smoke inhibited SOCS-3 expression in airway epithelial cells. Int Immunopharmacol. 2014; 19(1): 153-160. doi: 10.1016/j.intimp.2013.12.029
50. Nasreen N, Khodayari N, Sriram PS, Patel J, Mohammed KA. Tobacco Smoke induces Epithelial Barrier Dysfunction via Receptor EphA2 Signaling. Am J Physiol Cell Physiol. 2014. doi: 10.1152/ajpcell.00415.2012
51. Yuan Z, Mehta HJ, Mohammed KA, et al. TREM-1 Is Induced in Tumor Associated Macrophages by Cyclo-Oxygenase Pathway in Human Non-Small Cell Lung Cancer. PLoS One.2014; 9(5). doi: 10.1371/journal.pone.0094241
52. Yue Jin, Shenoy AK, Rottiers V, et al. FBXO11 regulates epithelial integrity and homeostasis by targeting Snail transcription factors for degradation. Cell Reports. 2014.