Jun Feng, MD, PhD

Assistant Professor of Surgery
Manager of Cardiothoracic Surgery Lab
CVRC, Rhode Island Hospital
Alpert Medical School of Brown University
Coro West 5th Floor, Room 5.2351 Hoppin Street
Providence RI 02903, USA

Biography

Dr. Feng is a graduate of Henan Medical University with special training in cardiovascular surgery in China. Dr. Feng then received his PhD in Physiology from University of Montreal, Canada and finished his postdoctoral training at Department of Surgery, School of Medicine, SUNY at Buffalo. Dr. Feng was then recruited as Research Assistant Professor of Surgery at School of Medicine, University of Miami, as Instructor of Surgery at BIDMC, Harvard Medical School. Dr. Feng is currently an Assistant Professor of Surgery at Warren Alpert Medical School of Brown University and at Department of Surgery, Cardiovascular Research Center, Rhode Island Hospital.
Dr. Feng serves as PI and co-investigator on grants funded by the Rhode Island Foundation and National Institute of Health. He has published more than 100 peer-review/editorial articles/book chapters and more than 110 abstracts as first authors and co-authors. He has served as editorial member and peer reviewer for a number of scientific journals in cardiovascular and surgical research.

Research Interest

His research interests include: patho-physiology of cardiopulmonary bypass, heart failure, myocardial infarction, myocardial engineering, peri-operative myocardial protection during cardiovascular surgery of adult and children.

Scientific Activities

MEMBERSHIP IN PROFESSIONAL SOCIETIES

• American Physiology Society (Regular Member: 1998-2000)
• International Society for Heart Research (Regular member: 1999-2002)
• American Heart Association (2000-Current)
• Calcium-activated potassium channels and microvascular function in animal and humans (PI) Bradykinin preconditioning of human microvasculature (PI)
• Myocardial stunning, and heart failure
• Coronary and peripheral microvascular reactivity after cardioplegia and cardiopulmonary bypass (NIH funded grant: Co-investigator)
• The molecular mechanisms of myocardial apoptosis following ischemia and reperfusion, especially during cardioplegic arrest
• Microvascular endothelial function following angiogenesis in diabetic and hypercholesterolemic pig models of chronic ischemia (NIH-Funded grant: Co-investigator)

Publications

ORIGINAL PUBLICATIONS IN PEER-REVIEWED JOURNALS

First Authors:

1. Feng J, Atanasiu R, Yamaguchi N, Lamontagne D, Chahine R, Nadeau R. Effects of ischemic preconditioning and hypothermia on ischemic contracture in the isolated rat heart. Medical Science Research. 1995; 23: 787-788.
2. Feng J, Wu GZ, Tang SB, Chahine R, Lamontagne D. Beneficial effects of iloprost cardioplegia in the ischemic arrest in isolated working rat heart. Prostaglandins Leukotrience Essential Fatty Acids. 1996; 62: 279-283. doi: http://dx.doi.org/10.1016/S0952-3278(96)90059-9
3. Feng J, Liu RY, Wu GZ, Tang SB. Pretreatment with tetramethylpyrazine increases the release of PGI2 and decreases TXA2 release in isolated rat heart. Planta Medicas. 1996; 62: 379-381. doi: 10.1055/s-2006-957915
4. Feng J, Liu RY, Wu GZ, Tang SB. Tetramethylpyrazine reduces cardiac-derived TXA2 release in isolated working rat heart. Medical Science Research. 1996; 24: 121-122.
5. Feng J, Liu RY, Wu GZ, Tang SB. PGE1 reduces cardiac-derived TXA2 in ischemic arrest in isolated working rat heart. Internal Journal Cardiology. 1996; 55: 265-270.
6. Feng J, Chahine R, Yamaguchi N, Lamontagne N, Nadeau R. Brief repetitive ischemia effects on norepinephrine release, functional recovery and arrhythmias in isolated perfused rat heart. Canadian Journal of Physiololgy and Pharmacology. 1996; 74: 1351-1358.
7. Feng J, Yamaguchi N, Chahine R, Lamontagne D, Nadeau R. Perfusate potassium: effect on ischemia-induced arrhythmias in preconditioning in the isolated rat heart. Medical Science Research. 1996; 24: 327-329.
8. Feng J, Yamaguchi N, Foucart S, Chahine R, Lamontagne D, Nadeau R. Transient ischemia inhibits nonexocytotic release of norepinephrine in the rat heart: Is bradykinin involved? Canadian Journal of Physiology and Pharmacology. 1997; 75: 665-670.
9. Feng J, Liu RY, Wu GZ, Tang SB. Effects of tetramethylpyrazine on the release of PGI2 and TXA2 in hypoxic rat heart. Molecular and Cellular Biochemistry. 1997; 167: 153-158.
10. Feng J, Wu GZ, Tang SB. The effects of tetramethylpyrazine on the incidence of arrhythmias and the release of PGI2 and TXA2 in the ischemic rat heart. Planta Medicas. 1999; 65: 268-270. doi: 10.1055/s-2006-960774
11. Feng J, Rosenkranz ER. Bradykinin pretreatment preconditions the heart by tyrosine kinase mediated pathways. Annals of Thoracic Surgery. 1999; 68: 1567-1572. doi: http://dx.doi.org/10.1016/S0003-4975(99)01041-3
12. Feng J, Li HL, Rosenkranz ER. Pinacidil pretreatment extends ischemia tolerance of neonatal rabbit hearts. Journal Surgical Research. 2000; 90: 131-137. doi: http://dx.doi.org/10.1006/jsre.2000.5865
13. Feng J, Li HL, Rosenkranz ER. Bradykinin protects the rabbit heart after cardioplegia via NO-dependent pathways. Annals of Thoracic Surgery. 2000; 70: 2119-2124. doi: http://dx.doi.org/10.1016/S0003-4975(00)02148-2
14. Feng J, Chahine R, Nadeau R. Influence of extracellular potassium on the antiarrhythmic effect of global preconditioning in isolated perfused rat heart. Molecular and Cellular Biochemistry. 2000; 214: 75-80.
15. Feng J, Schaus BJ, Fallavollita J, Lee TC, Canty JM. Preload induces troponin I degradation independently of myocardial ischemia. Circulation. 2001; 103: 2035-2037. doi: 10.1161/01.CIR.103.16.2035
16. Feng J, Li HL, Rosenkranz ER. Diazoxide protects the rabbit heart following cardioplegic ischemia. Molecular and Cellular Biochemistry. 2002; 233: 133-138.
17. Feng J, Li HL, Rosenkranz ER. KATP channel opener protects neonatal rabbit heart better than St. Thomas’ solution. Journal of Surgical Research. 2003; 109: 69-73. doi: http://dx.doi.org/10.1016/S0022-4804(02)00064-1
18. Feng J, Bianchi C, Li JY, Sellke FW. Improved profile of bad phosphorylation and caspase 3 activation after blood vs crystalloid cardioplegia. Annals of Thoracic Surgery. 2004; 77: 1384-1390. doi: http://dx.doi.org/10.1016/j.athoracsur.2003.09.053
19. Feng J, Bianchi C, Li JY, Sellke FW. Bradykinin preconditioning improves coronary microvascular reactivity during cardioplegia-reperfusion. Annals of Thoracic Surgery. 2005; 79: 911-916. doi: http://dx.doi.org/10.1016/j.athoracsur.2004.09.017
20. Feng J, Bianchi C, Sandmeyer JL, Li JY, Sellke FW. Bradykinin preconditioning improves the profile of cell survival proteins and limits apoptosis after cardioplegic arrest. Circulation. 2005; 112: I-190-195. doi: 10.1161/CIRCULATIONAHA.104.524454
21. Feng J, Bianchi C, Sandmeyer JL, Li JY, Sellke FW. Molecular indices of apoptosis after intermittent blood and crystalloid cardioplegic ischemia. Circulation. 2005; 112: I-184-189. doi: 10.1161/CIRCULATIONAHA.104.526160
22. Feng J, Sellke ME, Ramlawi B, et al. Bradykinin induces microvascular preconditioning via opening of calcium-activated potassium channels. Surgery. 2006; 140: 192-197. doi: http://dx.doi.org/10.1016/j.surg.2006.05.002
23. Feng J, Yano K, Monahan-Earley R, et al. Vascular bed-specific endothelium -dependent vasomomotor relaxation in the hagfish, myxine glutinosa. American Journal of Physiology (Regulatory, Integrative and Comparative). 2007; 293: R894-R900. doi: 10.1152/ajpregu.00080.2007
24. Feng J, Liu YH, Clements RT, et al. Calcium-activated potassium channels contribute to human coronary microvascular dysfunction after cardioplegia arrest. Circulation. 2008; 118 (Suppl I): S46-S51. doi: 10.1161/CIRCULATIONAHA.107.755827.
25. Feng J, Liu YH, Khabbaz KR, et al. Large conductance calcium-activated potassium channels contribute to the reduced myogenic tone of peripheral microvasculature after cardiopulmonary bypass. Journal of Surgical Research. 2009; 157: 123-128. doi: 10.1016/j.jss.2009.03.043.
26. Feng J, Liu YH, Khabbaz KR, et al. Endothelin-1 induced contractile responses of human coronary arterioles via endothelin-A receptors and PKC- signaling pathways . Surgery. 2010; 147: 798-804. doi: 10.1016/j.surg.2009.11.016.
27. Feng, J, Scott MD, Monica L, Sellke FW, Ferran CJ, Abid R. Endothelium-dependent coronary vasodilatation requires NADPH oxidase-derived ROS. Arterioscler Thromb Vasc Biol. 2010; 30: 1703-1710. doi: 10.1161/ATVBAHA.110.209726.
28. Feng J, Chu LM, Robich M, et al. Endothelin-1 induced contraction and signaling in the human skeletal muscle microcirculation. Circulation. 2010; 122: S150-S155. doi: 10.1161/CIRCULATIONAHA.109.928226.
29. Feng, J, Liu YH, Khabbaz K, et al. Decreased contractile response to endothelin-1 of peripheral microvasculature from diabetic patients. Surgery. 2011; 149: 247-252. doi: 10.1016/j.surg.2010.07.003.
30. Feng, J, Liu YH, Singh AK, et al. Impaired contractile response of human peripheral arterioles to thromboxane A-2 after cardiopulmonary bypass. Surgery. 2011; 150: 263-271. doi: 10.1016/j.surg.2011.06.004.
31. Feng, J, Liu YH, Chu LM, et al. Thromboxane induced contractile response of human coronary arterioles is diminished post-cardioplegic arrest. Annals of Thoracic Surgery. 2011; 92: 829-836. doi: 10.1016/j.athoracsur.2011.04.049.
32. Feng, J, Chu LM, Dobrilovic N, Liu YH, Singh AK, Sellke FW. Decreased coronary microvascular reactivity after cardioplegic arrest in patients with uncontrolled diabetes mellitus. Surgery. 2012; 152: 282-289. doi: 10.1016/j.surg.2012.04.009.
33. Feng, J, Liu YH, Chu LM, et al. Changes in microvascular reactivity after cardiopulmonary bypass in patients with poorly controlled versus controlled diabetes. Circulation. 2012; 126: S73-S80. doi: 10.1161/CIRCULATIONAHA.111.084590
34. Feng J, Liu YH, Dobrilovic N, et al. Altered apoptosis-related signaling after cardioplegic arrest in patients with uncontrolled type 2 diabetes . Circulation. 2013; 128: S144 -S151. doi: 10.1161/CIRCULATIONAHA.112.000332.
35. Feng J, Liu YH, Dobrilovic N, et al. Altered expression and activation of mitogen-activated protein kinases in diabetic heart during cardioplegic arrest and cardiopulmonary bypass. Surgery. 2013; 154: 436-443. doi: 10.1016/j.surg.2013.05.016.

Co-authors:

36. Chahine R, Feng J. Protective effects of taurine against reperfusion-induced arrhythmias in isolated ischemic rat heart. Arzneim Forch/Drug Res. 1998; 48: 360-364.
37. Thomas S, Fallavollita J, Lee TC, Feng J, Canty JM, Jr. Absence of troponin I degradation or altered sarcoplasmic reticulum uptake protein expression following reversible ischemia in swine. Circulation Research. 1999; 85: 446-456. doi: 10.1161/01.RES.85.5.446
38. Voisine P, Bianchi C, Ruel M, et al. Inhibition of the cardiac angiogenic response to exogenous vascular endothelial growth factor. Surgery. 2004; 136: 407-415. doi: http://dx.doi.org/10.1016/j.surg.2004.05.017
39. Khan TA, Bianchi C, Voisine P, et al. Reduction of myocardial reperfusion injury by aprotinin after regional ischemia and cardioplegic arrest. Journal of Thoracic and Cardiovascular Surgery. 2004; 128: 602-608. doi: http://dx.doi.org/10.1016/j.jtcvs.2004.02.037
40. Voisine P, Bianchi C, Khan TA, et al. Normalization of coronary microvascular reactivity and improvement in myocardial perfusion by surgical VEGF therapy combined with oral supplementation of L-arginine in a porcine model of endothelial dysfunction. Journal of Thoracic and Cardiovascular Surgery. 2005; 129: 1414-1420.
41. Khan TA, Bianchi C, Voisine P, Sandmeyer JL, Feng J, Sellke FW. Aprotinin inhibits protease-dependent platelet aggregation and thrombosis. Annals of Thoracic Surgery. 2005; 79: 1545-1550. doi: http://dx.doi.org/10.1016/j.athoracsur.2004.11.006
42. Khan TA, Bianchi C, Araujo E, et al. Aprotinin preserves coronary cellular junctions and reduces myocardial edema after regional ischemia and cardioplegic arrest. Circulation. 2005; 112: I-196-201. doi: 10.1161/CIRCULATIONAHA.104.526053
43. Voisine P, Li J, Bianchi C, et al. Effects of L-arginine on FGF-2-induced angiogenesis in a model of endothelial dysfunction. Circulation. 2005; 112: I-121-127. doi: 10.1161/CIRCULATIONAHA.104.526350
44. Nakai Y, Voisine P, Bianchi C, et al. Effects of L-arginine on the endogenous angiogenic response in a model of hypercholesterolemia. Surgery. 2005; 138: 291-298. doi: http://dx.doi.org/10.1016/j.surg.2005.06.013
45. Boodhwani M, Cohn WE, Feng J, et al. Safety and efficacy of novel gel for vascular occlusion in off-pump surgery. Annals of Thoracic Surgery. 2005; 80: 2333-2337. doi: http://dx.doi.org/10.1016/j.athoracsur.2005.05.031
46. Boodhwani M, Nakai Y, Mieno S, et al. Hypercholesterolemia impairs the myocardial angiogenic response in a swine model of chronic ischemia: Role of endostatin and oxidative stress. Annals of Thoracic Surgery. 2006; 81: 634-641. doi: http://dx.doi.org/10.1016/j.athoracsur.2005.07.090
47. Boodhwani M, Nakai Y, Voisine P, et al. High dose atorvastatin improves hypercholesterolemic coronary endothelial dysfunction without improving the angiogenic response. Circulation. 2006; 114: I402-I408. doi: 10.1161/CIRCULATIONAHA.105.000356
48. Boodhwani M, Feng J, Mieno S, et al. Effects of purification poloxamer 407 gel on vascular occlusion and the coronary endothelium. European Journal of Cardio-Thoracic Surgery. 2006; 29: 736-741. doi: 10.1016/j.ejcts.2006.02.024
49. Ramlawi B, Feng J, Mieno S, et al. Indices of apoptosis activation after blood cardioplegia and cardiopulmonary bypass. Circulation. 2006; 114 : I257-I263. doi: 10.1161/CIRCULATIONAHA.105.000828
50. Mieno S, Boodhwani M, Ramlawi B, et al. Human coronary microvascular effects of cardioplegia induced stromal derived factor-1. Annals of Thoracic Surgery. 2006; 82: 657-663. doi: http://dx.doi.org/10.1016/j.athoracsur.2006.03.044
51. Boodhwani M, Mieno S, Voisine P, et al. High-dose atorvastatin is associated with impaired myocardial angiogenesis in response to vascular endothelial growth factor in hypercholesterolemic swine. Journal of Thoracic Cardiovascular Surgery. 2006; 132: 1299-1306. doi: http://dx.doi.org/10.1016/j.jtcvs.2006.05.060< br> 52. Ramlawi B, Rudolph JL, Khabbaz K, et al. C Reactive protein and inflammatory response associated to neurocognitive decline following cardiac surgery. Surgery. 2006; 140: 221-226. doi: http://dx.doi.org/10.1016/j.surg.2006.03.007
53. Ramlawi B, Scott JR, Feng J, et al. Inhaled carbon monoxide prevents graft-induced intimal hyperplasia in swine . Journal of Surgical Research. 2007; 138: 121-127. doi: http://dx.doi.org/10.1016/j.jss.2006.08.031
54. Khan T, Bianchi C, Ruel M, Feng J, Sellke FW. Differential effects on the mesentery microcirculatory response to vasopressin and phenylephrine after cardiopulmonary bypass. Journal of Thoracic Cardiovascular Surgery. 2007; 133: 682-688. doi: http://dx.doi.org/10.1016/j.jtcvs.2006.09.025
55. Sodha NR, Feng J, Clements RT, et al. Protein Kinase Ca modulates microvascular reactivity in the human coronary and skeletal microcirculation. Surgery. 2007; 142: 243-252. doi: http://dx.doi.org/10.1016/j.surg.2007.03.010
56. Boodhwani M, Mieno S, Sodha NR et al. Functional, cellular, and molecular characterization of the angiogenic response to chronic myocardial ischemia in diabetes. Circulation. 2007; 116: I31-137. doi: 10.1161/CIRCULATIONAHA.106.680157
57. Sodha NR, Boodhwani M, Clements RT, et al. Coronary microvascualr dysfunction in the setting of chronic ischemia is independent of arginase activity. Microvascular Research. 2007; 75: 238-246. doi: 10.1016/j.mvr.2007.06.008
58. Clements RT, Sodha NR, Feng J, et al. Cardioplegia and cardiopulmonary bypass induces phosphorylation and myofilament localization of heat shock protein 27 and αB-crystallin in human myocardium. Journal of Thoracic and Cardiovascular Surgery. 2007; 134: 1461-1470. doi: http://dx.doi.org/10.1016/j.jtcvs.2007.06.026
59. Boodhwani M, Sodha NR, Xu SH, et al. Insulin treatment enhances the myocardial angiogenic response in diabetes. Jounal of Thoracic and Cardiovascular Surgery. 2007; 134: 1453-1460. doi: http://dx.doi.org/10.1016/j.jtcvs.2007.08.025
60. Sodha NR, Boodhwani M, Ramlawi B, et al. Atorvastatin increases myocardial indices of oxidative stress in a porcine model of hypercholesterolemia and chronic ischemia. Journal of Cardiac Surgery. 2008; 23: 312-320. doi: 10.1111/j.1540-8191.2008.00600.x.
61. Khabbaz KR, Feng J, Boodhwani M, Clements RT, Bianchi C, Sellke FW. Non-ischemic myocardial acidosis adversely affects microvascular and myocardial function and triggers apoptosis during cardioplegia. Journal of Thoracic Cardiovascular Surgery. 2008; 135: 139-146.
62. Boodhwani M, Mieno S, Feng J, et al. Atorvastatin impairs the myocardial angiogenic response to chronic ischemia in normocholesterolemic swine. Journal of Thoracic and Cardiovascular Surgery. 2008; 135: 117-122. doi: 10.1016/j.jtcvs.2007.04.021.
63. Boodhwani M, Voisine P, Ruel M, et al. Comparison of vascular endothelial growth factor and fibroblast growth factor-2 in swine model of endothelial dysfunction. European Journal of Thoracic and Cardiovascular Surgery. 2008; 33: 645-650. doi: 10.1016/j.ejcts.2007.12.016.
64. Sodha NR, Clements RT, Feng J, et al. The effects of therapeutic sulfide on myocardial apoptosis in response to ischemia-reperfusion injury. European Journal of Thoracic Cardiovascular Surgery. 2008; 33: 906-913. doi: 10.1016/j.ejcts.2008.01.047.
65. Liu YH, Sellke EW, Feng J, et al. Calcium-activated potassium channels contribute to human skeletal muscle microvascular endothelial dysfunction related to cardiopulmonary bypass. Surgery. 2008; 144: 239-244. doi: 10.1016/j.surg.2008.03.032.
66. Clements RT, Smejka G, Sodha NR , et al. Pilot proteomic profile of differentially regulated proteins in right atrial appendage before and after cardiac surgery using cardioplegia and cardiopulmonary bypass. Circulation. 2008; 118: S24-S31. doi: 10.1161/CIRCULATIONAHA.107.792747.
67. Clements RT, Sodha NR, Feng J, et al. Impaired coronary vasodilation correlates with enhanced smooth muscle MLC phosphorylation in Diabetes. Microcirculation. 2009; 16: 193-206. doi: 10.1080/10739680802461950.
68. Sodha NR, Clements R, Feng J, et al. Hydrogen sulfide therapy attenuates the inflammatory response in a porcine model of myocardial ischemia/reperfusion injury. Journal of Thoracic and Cardiovascular Surgery. 2009; 138: 977-984. doi: 10.1016/j.jtcvs.2008.08.074.
69. Osipov RM, Bianchi C, Feng J, et al. Effect of hypercholesterolemia on myocardial necrosis and apoptosis in the setting of ischemia reperfusion. Circulation. 2009; 120: S22-S30. doi: 10.1161/CIRCULATIONAHA.108.842724.
70. Osipov RM, Robich M, Feng J, et al. The effect of thrombin fragment (TP508) on myocardial ischemia reperfusion injury in hypercholesterolemic pigs. Journal of Applied Physiology. 2009; 106: 1993-2001. doi: 10.1152/japplphysiol.00071.2009.
71. Osipov RM, Bianchi C, Clements RT, et al. Thrombin fragment (TP508) decreases myocardial infarction and apoptosis after ischemia reperfusion injury. Annals of Thoracic Surgery. 2009; 87: 786-793. doi: 10.1016/j.athoracsur.2008.12.021.
72. Osipov RM, Robich MP, Feng J, et al. Effect of hydrogen sulfide in a porcine model of myocardial ischemia-reperfusion: comparison of different administration regimens and characterization of the cellular mechanisms of protection. Journal of Cardiovascular Pharmacology. 2009; 54: 287-297. doi: 10.1097/FJC.0b013e3181b2b72b.
73. Qiu L, Chuttani R, Zhang S, et al. Diagnostic imaging of esophageal epithelium with clinical endoscopic polarized scanning spectroscopy instrument. Conf Proc IEEE Eng Med Biol Soc. 2009; 2009: 1997-2000. doi: 10.1109/IEMBS.2009.5333427.
74. Robich MP, Araujo EG, Feng J, et al. Altered coronary microvascular serotonin receptor expression after cardiac surgery. Journal of Thoracic and Cardiovascular Surgery. 2010; 139: 1033-1040. doi: 10.1016/j.jtcvs.2009.05.032.
75. Osipov RM, Robich MP, Feng J, et al. Effect of hydrogen sulfide on myocardial protection in the setting of cardioplegia and cardiopulmonary bypass. Interactive Cardiovascular and Thoracic Surgery. 2010; 10: 506-512. doi: 10.1510/icvts.2009.219535
76. Oyamada S, Bianchi C, Robich MP, et al. Effect of dimerized thrombin fragment TP508 on acute myocardial ischemia reperfusion injury in hypercholesterolemic swine. Journal of Pharmacology Experimental Therapeutics. 2010; 334: 449-459. doi: 10.1124/jpet.110.166348.
77. Chu LM, Osipov RM, Robich MP, Feng J, Sheller MR, Sellke FW. The Effect of thrombin fragment (TP508) on myocardial ischemia reperfusion injury in a model of type 1 diabetes. Circulation. 2010; 122: S162-S169. doi: 10.1161/CIRCULATIONAHA.109.928374.
78. Robich MP, Osipov R, Nezafat R, et al. Resveratrol improves myocardial perfusion in a swine model of hypercholesterolemia and chronic myocardial ischemia. Circulation. 2010; 122: S142-S149. doi: 10.1161/CIRCULATIONAHA.109.920132.
79. Robich MP, Osipov R, Chu L, et al. Temporal and spatial changes in collateral formation and function during chronic myocardial ischemia. Journal of American College Surgeon. 2010; 211: 470-480. doi: 10.1016/j.jamcollsurg.2010.06.009.
80. Chu LM, Osipov RM, Robich MP, et al. Is hyperglycemia bad for the heart during acute ischemia? Journal of Thoracic and Cardiovascular Surgery. 2010; 140: 1345-1352. doi: 10.1016/j.jtcvs.2010.05.009.
81. Robich MP, Matyal R, Chu LM, et al. Effects of neuropeptide Y on collateral development in a swine model of chronic myocardial ischemia. Journal of Molecular and Cellular Cardiology. 2010; 49: 1022-1030. doi: 10.1016/j.yjmcc.2010.08.022.
82. Robich MP, Chu LM, Feng J, et al. Effects of selective cyclooxygenase-2 and nonselective cyclooxygenase inhibition on ischemic myocardium. Journal of Thoracic and Cardiovascular Surgery. 2010; 140: 1143-1152. doi: 10.1016/j.jtcvs.2010.06.057.
83. Robich MP, Chu LM, Burgess TA, Feng J, Bianchi C, Sellke FW. Effects of selective cyclooxygenase-2 and nonselective cyclooxygenase inhibition on myocardial function and perfusion. Journal of Cardiovascular Pharmacology. 2011; 57: 122-130. doi: 10.1097/FJC.0b013e3182010a96.
84. Clements RT, Feng J, Cordeiro B, Bianchi C, Sellke FW. p38-MAPK-dependent small heat shock protein 27 (HSP27) and αB-crystallin (cryAB) phosphorylation in regulation of myocardial function following cardioplegic arrest. American Journal of Physiology. 2011; 300: H1669-H1677. doi: 10.1152/ajpheart.00272.2010.
85. Robich MP, Osipov RM, Chu LM, et al. Resveratrol modifies risk factors for coronary artery disease in swine with metabolic syndrome and myocardial ischemia. European Journal of Pharmacology. 2011; 664: 45-53. doi: 10.1016/j.ejphar.2011.04.059
86. Clements RT, Cordeiro B, Feng J, Bianchi C, Sellke FW. Rottlerin increases cardiac contractile performance and coronary perfusion following cold cardioplegic arrest in isolated hearts. Circulation. 2011; 124: S555-561. doi: 10.1161/CIRCULATIONAHA.110.012112.
87. Chu LM, Robich MP, Lassaletta AD, et al. Resveratrol supplementation abrogates pro-angiogenic effects of intramyocardial VEGF in a hypercholesterolemic swine model of chronic ischemia. Surgery. 2011; 150: 390-399. doi: 10.1016/j.surg.2011.06.009.
88. Chu LM, Robich MP, Lassaletta AD, et al. High-fat diet alters prostanoid balance and perfusion in ischemic myocardial of naproxen treated swine. Surgery. 2011; 150: 490-496. doi: 10.1016/j.surg.2011.07.022.
89. Chu LM, Robich MP, Bianchi C, et al. Effects of cyclooxygenase inhibition on cardiovascular function in a hypercholesterolemic swine model of chronic ischemia. American Journal of Physiology. 2012; 302: H479-488. doi: 10.1152/ajpheart.00146.2011.
90. Lassaletta AD, Chu LM, Robich MP, et al. Overfed Ossabaw swine with early stage metabolic syndrome have normal coronary collateral development in response to chronic ischemia. Basic Research in Cardiology. 2012; 107: 1-11. doi: 10.1007/s00395-012-0243-y.
91. Lassaletta AD, Chu LM, Elmadhun NY, et al. Cardioprotective effects of red wine and vodka in a model of endothelial dysfunction. Journal of Surgical Research 2012; 178: 586-592. doi: 10.1016/j.jss.2012.06.009
92. Robich MP, Chu LM, Burgess TA, et al. Resveratrol preserves myocardial function and perfusion in remote nonischemic myocardium in a swine model of metabolic syndrome. Journal of American College Surgeon. 2012; 215: 681-689. doi: 10.1016/j.jamcollsurg.2012.06.417.
93. Elmadhun NY, Lassaletta AD, Chu LM, Liu Y, Feng J, Sellke FW. Atorvastatin increases oxidative stress and modulates angiogenesis in Ossabaw swine with the metabolic syndrome. Journal of Thoracic and Cardiovascular Surgery. 2012; 144: 1486-1493. doi: 10.1016/j.jtcvs.2012.08.065.
94. Lassaletta AD, Elmadhun NY, Liu Y, et al. Ethanol promotes arteriogenesis and restores perfusion to chronically ischemic myocardium. Circulation. 2013; 128: S136-S143. doi: 10.1161/CIRCULATIONAHA.112.000207.
95. Shafique E, Choy WC, Liu Y, et al. Oxidative stress improves coronary endothelial function through activation of the pro-survival kinase AMPK. Aging. 2013; 5(7): 515-530.
96. Lassaletta AD, Elmadhun NY, Zanetti AV, et al. Rapamycin treatment of healthy pigs subjected to acute myocardial ischemia-reperfusion injury attenuates cardiac functions and increases myocardial necrosis. Annals of Thoracic Surgery. 2014; 97(3): 901-907. doi: 10.1016/j.athoracsur.2013.09.059.

OTHER PEER-REVIEWED PUBLICATIONS

1. Feng J, Sellke FW. Cardiomyocyte apoptosis following antegrade and retrograde cardioplegia (Invited Commentary). Annals of Thoracic Surgery. 2005; 80: 2234.
2. Feng J, Sellke FW. Pravastatin improves remodeling and cardiac function after myocardial infarction by an anti-inflammatory mechanism rather than by the induction of angiogenesis (Invited Commentary). Annals of Thoracic Surgery. 2006: 81: 2225-2226.
3. Feng J, Sellke FW. Enhanced angiogenesis with multimodal cell-based gene therapy (Invited Commentary). Annals of Thoracic Surgery. 2007; 83: 1119-1120.
4. Feng J, Sellke FW. Heat Shock proteins 27, 60, 70, 90 and 20S proteasome in on- versus off-pump coronary artery bypass graft patients. Annals of Thoracic Surgery. (Invited Commentary). 2008; 85: 87-88.
5. Feng J, Sellke FW. Tight glycemic control protects the myocardium and reduces inflammation in neonatal heart surgery (Invited Commentary). Annals of Thoracic Surgery. 2010; 90: 30.
6. Feng J. Endothelium-dependent vasoconstrictions in isolated vessel grafts: a novel mechanism of vasospasms? Annals of Thoracic Surgery. 2011; 92: 1307.
7. Feng J, Sellke FW. Transforming growth factor-alpha enhances stem cell- mediated post-ischemic myocardial protection (Invited Commentary). Annals of Thoracic Surgery. 2011; 92: 1726.
8. Feng J. Mammalian fetal Cardiac regeneration following myocardial infarction is associated with differential gene expression compared to the adult (Invited Commentary). Annals of Thoracic Surgery. 2014; 97(5): 1650-1651.