Julia Yue Cui, PhD


Assistant Professor
Department of Environmental &
Occupational Health Sciences
University of Washington
4225 Roosevelt Way NE
Washington, USA

Biography

Dr. Julia received her BS Degree in Chukechen Honors College, Zhejiang University in Hangzhou, China, and received her PhD Degree with honors in University of Kansas Medical Center under the mentorship of Dr. Curtis D. Klaassen. Julia currently is an Assistant Professor in Toxicology in the Department of Environmental and Occupational Health Sciences. Julia is trained as a toxicologist, specializing in using transgenic animal models and the Next-Generation Sequencing technology to determine the effects of environmental chemical exposure and reprogramming the gut microbiome on the transcriptional and epigenetic regulation of genes involved in drug metabolism and obesity during development.

Research Interest

Her research interests include: How developmental exposure to environmental chemicals reprograms the epigenetic memory and the nuclear receptors PXR and CAR signaling to modulate drug metabolism and transport during and beyond childhood, and How the gut mcrobiome modulates the ontogeny of genes that are involved in drug metabolism and obesity, and how the developmental reprogramming of gut microbiome by probiotics and antibiotics modulate pediatric pharmacology and childhood obesity.

Scientific Activities

PROFESSIONAL MEMBERSHIPS

• (2006-Present) SOT (Society of Toxicology)
• (2007-Present) Sigma Xi
• (2009-Present) AAAS (The American Association for the Advancement of Science)
• (2009-Present) ISSX (International Society for the Study of Xenobiotics)
• (2012-Present) AHA (American Heart Association)
• (2014-Present) Member of CEEH (Center for Ecogenetics & Environmental Health)

HONORS

• (2006) 1ST Place Student Platform Presentation Research Award of Central States Society of Toxicology (CSSOT), and recipient of Travel Award to the 2007 National Society of Toxicology Meeting
• (2006) 1ST Place Platform Presentation Research Award of the Student Research Forum, the Genetics Session, the University of Kansas Medical Center
• (2007) 1ST Place Platform Presentation Research Award of the Student Research Forum, the Molecular Biology Session, the University of Kansas Medical Center
• (2008) Presidential Poster of Distinction at the 59th National Meeting of American Association for the Study of Liver Diseases (AASLD)
• (2008) Recipient of Dr. Daniel Azarnoff Student Travel Award, Department of Pharmacology, Toxicology and Therapeutics, the University of Kansas Medical Center
• (2008) Graduate Student Travel Award, the University of Kansas Medical Center
• (2008) First Place Carl C. Smith Award, National Meeting of Society of Toxicology
• (2008) 1ST Place Student Poster-Presentation Award of Central States Society of Toxicology (CS-SOT) and recipient of Travel Award to the 2008 National Society of Toxicology Annual Meeting
• (2008) 1ST Place Student Platform-Presentation Award of Central States Society of Toxicology (CS-SOT) Annual Meeting
• (2008) 1ST Place Platform Presentation Award of the Student Research Forum, Molecular Biology Session, the University of Kansas Medical Center
• (2008 Recipient of Student Union Corporation Travel Scholarship, the University of Kansas Medical Center
• (2009) Winner of Novartis Graduate Student Fellowship, National Society of Toxicology Meeting
• (2009) Honorable Mention abstract by the Molecular Biology Specialty Section, National Society of Toxicology Meeting
• (2009) Recipient of Dr. Daniel Azarnoff Student Travel Award, Department of Pharmacology, Toxicology and Therapeutics, the University of Kansas Medical Center
• (2009) 1ST Place Pre-doctoral Poster Presentation, 16th North American Regional International Society for the Study of Xenobiotics (ISSX) Annual Meeting (title: “ChIPing the cistrome of PXR in mouse liver”)
• (2010) 1ST Place Platform Presentation Research Award of the Student Research Forum, Basic Science I, the University of Kansas Medical Center
• (2011) 1ST Place Platform Presentation Research Award of the K-INBRE (Kansas IDeA Network of Biomedical Research Excellence) Symposium (title: “microRNAs are essential for bile acid homeostasis during liver development”)
• (2011) Mechanisms Specialty Section Gabriel L. Plaa Education Award, Society of Toxicology
• (2011) 1ST Place Platform Presentation Research Award of Central State Society of Toxicology Meeting
• (2012) 1st Place Platform Presentation Postdoctoral Research Award, Postdoctoral Research Day, University of Kansas Medical Center
• (2014) Recipient of the Sheldon D. Murphy Endowed Chair Assistant Professor position, DEOHS, University of Washington

Publications

Selected Peer-reviewed Publications

1. Aleksunes LM, Cui Y, Klaassen CD. Prominent expression of xenobiotic efflux transporters in mouse extraembryonic fetal membranes compared with placenta. Drug Metab Disp. 2008; 36:1960-1970. doi: 10.1124/dmd.108.021337
2. Cui YJ, Yeager RL, Zhong XB, Klaassen CD. Ontogenic expression of hepatic AhR mRNA correlates with histone H3K4 di-methylation during mouse liver development. Toxicol Letters. 2009; 189: 184-190. doi: 10.1016/j.toxlet.2009.05.017
3. Cui YJ, Cheng X, Weaver YM, Klaassen CD. Tissue distribution, gender divergent expression, ontogeny, and chemical induction of multidrug resistance transporter genes (Mdr1a, Mdr1b,Mdr2) in mice. Drug Metab Disp. 2009; 37: 203-210. doi: 10.1124/dmd.108.023721
4. Cui Y, Aleksunes LM, Tanaka Y, Goedken MJ, Klaassen CD. Compensatory induction of liver efflux transporters in response to ANIT-induced liver injury is impaired in FXR-null mice. Toxicol Sci. 2009; 110: 47-60. doi: 10.1093/toxsci/kfp094
5. Li Y, Cui Y, Hart SN, Klaassen CD, Zhong X. Dynamic patterns of histone methylation are associated with ontogenic expression of the Cyp3a genes during mouse liver maturation. Mol Pharmacol. 2009; 75: 1171-1179. doi: 10.1124/mol.108.052993
6. Hart SN, Cui Y, Klaassen CD, Zhong XB. (Three patterns of cytochrome P450 gene expression during liver maturation in mice. Drug Metab Disp . 2009; 37: 116-121.
7. Choudhuri S, Cui Y, Klaassen CD. Molecular targets of epigenetic regulation and effectors of environmental influences. Toxicology and Applied Pharmacology. 2010; 245: 378-393.
8. Tanaka Y, Aleksunes LM, Cui YJ, Klaassen CD. ANIT-induced intrahepatic cholestasis alters hepatobiliary transporter expression via Nrf2 dependent and independent signaling.Toxicol Sci. 2009; 108: 247-257. doi: 10.1093/toxsci/kfp020
9. Cui YJ, Gunewardena SS, Klaassen CD. ChIPing the cistrome of PXR in mouse liver.Nucleic Acids Research. 2010; 38: 7943-7963. doi: 10.1093/nar/gkq654
10. Staudinger JL, Xu CS, Cui YJ, Klaassen CD. Nuclear receptor mediated regulation of carboxylesterase expression and activity. Expert Opinion on Drug Metabolism and Toxicology. 2010; 261-271.doi: 10.1517/17425250903483215
11. Cui YJ, Choudhuri S, House-Knight T, Klaassen CD. Genetic and epigenetic regulation and expression signatures of glutathione S-transferases in developing mouse liver. Toxicological Sciences. 2010; 115: 32-43. doi: 10.1093/toxsci/kfq115
12. Klaassen CD, Lu H, Cui JY. Epigenetic regulation of drug processing genes. Toxicol Mech Methods. 2011; 21: 312-324. doi: 10.3109/15376516.2011.562758
13. Cui JY, Gunewardena SS, Yoo B, et al. RNA-Seq reveals different mRNA abundance of transporters and their alternative transcript isoforms during liver Development. Toxicol Sci. 2012; 127: 592-609. doi: 10.1093/toxsci/kfs107
14. Peng L, Cui JY, Yoo B, et al. RNA sequencing quantification of hepatic ontogeny of phase-I enzymes in mice. Drug Metab Dispos. 2013; 41: 2175-2186. doi: 10.1124/dmd.113.054635
15. Renaud HJ, Cui JY, Lu H, Klaassen CD. Effect of diet on expression of genes involved in lipid metabolism, oxidative stress, and inflammation in mouse liver – insights into mechanisms of metabolic diseases. Plos One. 2014; 9(2): e88584. doi: 10.1371/journal.pone.0088584