Jose Pablo Leone, MD

Clinical Assistant Professor
Department of Medicine
Division of Hematology, Oncology and Blood and Marrow
University of Iowa Carver College of Medicine
IA 52242, USA


Dr. Leone is a Medical Oncologist and Clinical Assistant Professor of Medicine at the University of Iowa Carver College of Medicine. Dr. Leone did his residency in Internal Medicine at University of Miami and his fellowship in Hematology and Oncology at the University of Pittsburgh.

Research Interest

His research interests are in the field of breast cancer, in particular in high risk patients and development of new therapies.

Scientific Activities


• Graduated with Diploma of Honor for being one of the top student
• (12/2004-12/2005) Chief of Teacher Assistants of the Department of Physiology, Universidad del Salvador


1. Leone JP, Dudek AZ. Enzyme replacement therapy for Gauchers disease in patient treated for non-small cell lung cancer. Anticancer Research. 2008; 28(6B): 3937-3939.
2. Leone JP, Cabaleiro P, Iturbe J, et al. Metastasis of breast carcinoma to spinal meningioma. The Breast Journal. 2009; 15(5): 539-540. doi: 10.1111/j.1524-4741.2009.00776.x
3. Álvarez RH, Leone JP, Valero V. Terapia antiangiogénica en el cáncer de mama [Spanish]. Revista de Angiogénesis Tumoral. 2009; 1(1): 22-32.
4. Iturbe J, Leone JP, Zwenger A, Vallejo C, Leone B. Neoadjuvant endocrine treatment of women with breast cancer. Oncology Reviews. 2011; 5(3): 157-166. doi: 10.1007/s12156-011-0083-2
5. Iturbe J, Zwenger A, Leone JP, et al. Treatment of early breast cancer, a long-term follow-up study: The GOCS experience. The Breast Journal. 2011; 17(6): 630-637. doi: 10.1111/j.1524-4741.2011.01157.x
6. Leone JP, Álvarez RH. The intriguing role of bevacizumab in advanced breast cancer- the search continues. European Oncology & Haematology. 2012; 8(3): 179-183.
7. Hurley J, Reis IM, Rodgers SE, et al. The use of neoadjuvant platinum-based chemotherapy in locally advanced breast cancer that is triple negative: Retrospective analysis of 144 patients. Breast Cancer Research and Treatment. 2013; 138(3): 783-794. doi: 10.1007/s10549-013-2497-y
8. Leone JP, Álvarez RH. The role of everolimus in the teatment of breast cancer. Journal of Cancer Therapy. 2013; 4(7): 1167-1176. doi: 10.4236/jct.2013.47136
9. Leone JP, Puhalla S. Triple-Negative breast cancer: Not entirely negative. Oncology (Williston Park). 2013; 27(9): 856, 858-859.
10. Leone JP, Leone J, Vallejo CT, et al. Sixteen years follow-up results of a randomized phase II trial of neoadjuvant fluorouracil, doxorubicin and cyclophosphamide (FAC) compared with cyclophosphamide, methotrexate and 5-fluorouracil (CMF) in stage III breast cancer: GOCS experience. Breast Cancer Research and Treatment. 2014; 143(2): 313-323.
11. Leone JP, Bhattacharya S, Socinski MA, et al. Metastasis of breast carcinoma to the maxillary sinus. The Breast Journal. 2014; 20(3): 318-319.
12. Leone JP, Lee A, Brufsky A. Prognostic factors and survival of patients with brain metastasis from breast cancer who underwent craniotomy. Cancer Medicine. 2015; 4(7): 989-994. doi: 10.1002/cam4.439
13. Leone JP, Leone J, Zwenger AO, Iturbe J, Vallejo CT, Leone BA. Prognostic significance of tumor subtypes in male breast cancer: A population-based study. Breast Cancer Research and Treatment. 2015; 152(3): 601-609. doi: 10.1007/s10549-015-3488-y
14. Leone JP, Bhargava R, Theisen BK, Hamilton RL, Lee AV, Brufsky AM. Expression of high affinity folate receptor in breast cancer brain metastasis. Oncotarget. 2015; 6(30): 30327-30333. doi: 10.18632/oncotarget.4639
15. Zwenger AO, Grosman G, Iturbe J, et al. Expression of ERCC1 and TUBB3 in locally advanced squamous cervical cancer and its correlation with different therapeutic regimens. The International Journal of Biological Markers. 2015; 30(3): e301-e314. doi: 10.5301/jbm.5000161
16. Wang P, Bahreini A, Gyanchandani R, et al. Sensitive detection of mono- and polyclonal ESR1 mutations in primary tumors, metastatic lesions and cell free DNA of breast cancer patients. Clinical Cancer Research. 2016; 22(5): 1130-1137.
17. Monga V, Leone JP. Metastatic adenoid cystic carcinoma of the breast. The Breast Journal. 2016; 22(2): 239-240.
18. Leone JP, Leone BA. Breast cancer brain metastases: The last frontier. Experimental Hematology & Oncology. 2015; 4: 33. doi: 10.1186/s40164-015-0028-8
19. Leone JP. Gemcitabine induced cutaneous collagenous vasculopathy in a breast cancer patient. The Breast Journal. 2016. doi: 10.1111/tbj.12638
20. Leone J, Perez JE, Dominguez ME, et al. Role of difucosylated Lewis Y antigen in outcome of locally advanced cervical squamous cell carcinoma treated with cisplatin regimen. The International Journal of Biological Markers. 2016; 31(3): e300-e308. doi: 10.5301/jbm.5000206
21. Recondo G Jr, de la Vega M, Galanternik F, Díaz-Cantón E, Leone BA, Leone JP. Novel approaches to target HER2-positive breast cancer: Trastuzumab emtansine. Cancer Management and Research. 2016; 8: 57-65. doi: 10.2147/CMAR.S104447
22. Leone JP, Zwenger AO, Iturbe J, et al. Prognostic factors in male breast cancer: A population-based study. Breast Cancer Research and Treatment. 2016; 156(3): 539-548. doi: 10.1007/s10549-016-3768-1.
23. Leone J, Leone BA, Leone JP. Adjuvant systemic therapy in older women with breast cancer. Breast Cancer: Targets and Therapy. 2016; 8: 141-147.
24. Nadiminti K, Leone JP. Intraocular bevacizumab in the treatment of choroidal metastases from breast cancer. BMJ Case Reports. 2016; 2016. doi: 10.1136/bcr-2016-215719