Johan H. M. Frijns, MD, PhD

Professor
Department of Otorhinolaryngology
Head Of Centre for Audiology and Hearing Implants
Leiden University Medical Center
Albinusdreef 2, 2333 ZA Leiden, Netherlands

Biography

Dr. Frijns (1961) has a Masters degree in Applied Physics (Hons., 1983, Delft) and an MD degree (Hons., 1988, Leiden). In September 1988 he started with his research on cochlear implants in the ENT-Department of what now is called the LUMC. Between 1989 and 1994 he was educated to become an ENT-Specialist and from then on he was affiliated to this clinic as a staff member. In 1995 he completed his PhD thesis (Hons.), entitled Cochlear Implants – A Modelling Approach (promotor Prof.Dr. J.J. Grote, Leiden and co-promotor Dr. J.H. ten Kate, Delft). This thesis was awarded the 1995 prize of the Dutch ENT society, and the second prize (1995-1996) of the Dutch Biophysical Society. In 1996 he was awarded the C.J. Kokprijs 1994 of the Leiden University. Clinically he sub-specialised in (neuro-)otology. In 1999 he founded CIRCLE, the Leiden cochlear and auditory brainstem implant program, building on the growing body of translational research on the subject of his group. At present, CIRCLE has implanted more than 850 patients (adults and children), with outcomes ranking amongst the worlds best. Frijns is teacher in a number of post-academic courses and organized several international conferences. In 2005 he became professor in Otology and Auditory Physics on behalf of the Heinsius-Houbolt Foundation. From 2005 to 2010 he was Chairman of the ENT-department of the LUMC. Since January 2006 he holds the ordinary Chair of Otorhinolaryngology. At present he is Chairman of the Centre for Audiology and Hearing Implants at the LUMC.

Research Interest

His research interest includes: Otolaryngology.

Scientific Activities

HONORS AND AWARDS

• (1996), Winner of the CJ Kok 1994 award (Leiden University)
• (1995), PhD Leiden University (Cum Laude)
• (1995), Honored with the 1995 annual award of the Dutch ENT Society
• (1995-1996), Honored with the 2nd prize of the Dutch Society of Biophysics for the best Biophysical thesis in the year 1995 and 1996

MEMBERSHIPS

• (2015), Member of Advisory Appointment Committee for the Chair of Bioelectronics, Faculty of Electrical Engineering, Mathematics, Computer Science, Department of Microelectronics, Delft University of Technology
• (2013-Present), Deputy Chair Examination Board of Bachelor/Master Program Clinical Technology (Leiden University, Erasmus University Rotterdam, Delft University of Technology)
• (2012-Present), Core member on behalf of the LUMC of the committee to develop the Bachelor and Master of Clinical Technology (collaboration of Delft University of Technology, Erasmus MC and Leiden University Medical Centre)
• (2012-2014), Member of the committee (on behalf of Dutch ENT society) to formulate the Standard Hearing Loss for the Dutch Society of General Practitioners
• (2011-2012), Chairman of committee to formulate National Guideline for Diagnosis and Therapy for Acquired Sensorineural Hearing Loss (Dutch ORL Society)
• (2010-2011), Member of the 2nd Workgroup Safety Management System for the Medical Equipment Chain, LUMC
• (2010-Present), Chairman of the Curatorium of the Chair Social and Emotional Development in Children with Auditory and/or Communicative Disorders, Faculty of Social Sciences, Leiden University
• (2010-Present), Member of the EAONO standing committee for Research and Investigation
• (2009), Member of the Workgroup Safety Management System for the Medical Equipment Chain, LUMC
• (2008-Present), Senior Member of the Leiden Institute for Brain and Cognition http://www.libc-language.nl/index.php/people/11-people/senior/22-johan-frijns
• (2008-Present), Member of National Audit Committee for ENT Resident Training
• (2007-Present), Collegium Otorhinolaryngologicum Amicitiae Sacrum (CORLAS)
• (2006-2008), Executive committee of Dutch project group ENT Education Revised (ENTER)
• (2006-Present), Initiative Group for a Nationwide Hearing Platform
• (2006-2008), Advisory Committee LCTI (Dutch Committee for Supervision of Indications) on indications for special educational settings for children with a cochlear implant
• (2006-2007), Advisory Committee for Annual Dutch ENT Award
• (2005-Present), The Dutch Concilium Otorhinolaryngologicum
• (2005-Present), Steering committee and several working groups CI-meeting, Netherland (CI-ON) (Dutch Cochlear Implant Society)
• (2006-2007), Taskforce reduction of illness leave Division 3 LUMC
• (2005-2006), Secretary, thereafter chairman of Examination Board for Dutch ENT Residents Specieel Basaal Examen voor de opleiding tot KNO-arts
• (2004-2005), Departmental Support Team for Traumatic Events (AOT) for ENT, Ophthalmology and Dermatology
• (2004-2005), Budget Committtee ENT department LUMC
• (2004), Chairman and founding member steering committee and national board CI in prelingually deaf children, Presently CI-ON
• (2002-Present), Politzer Society
• (2000-2005), The Committee of Professional Interests for Academic specialists of the Dutch ENT Society
• (1999-Present), European Association of Otology and Neurotology (EAONO)
• (1999-2005), Vice-chairman committee on informatics and communication technology division III LUMC
• (1998-Present), Member of the Society of Dutch Medical Specialists (Orde van Medisch Specialisten)
• (1998-Present), Member of the Royal Dutch Medical Society (KNMG)
• (1998-Present), Member of the Skull Base Workgroup (LUMC)
• (1998-2005), The Council of Academic Medical Specialists in Leiden (ASVL)
• (1995-Present), Member of Committee on Ototoxicity (LUMC)
• (1995-Present), The Dutch Association of Biophysics (Nederlandse Vereniging voor Biofysica)
• (1995-Present), The Flemish-Dutch Otology Society (Vlaams-Nederlands Oorheelkundig Genootschap) March 26-27, 2010: Organisation of the annual meeting
• (1993-Present), The Association for Research in Otolaryngology (ARO)
• (1991-Present), IEEE & Biomedical Engineering Society
• (1988-Present), The Dutch ENT Society

Publications

1. Frijns JHM, Raatgever J, Bilsen FA. A central spectrum theory of binaural processing. The binaural edge pitch revisited. J Acoust So Am. 1986; 80(2): 442-451.
2. Dessel T van, Frijns JHM, Kok FThJGTh, Wallenburg HCS van. Assessment of cervical dilatation during labor: a review, Eur J Obstet Gynecol Reprod Biol. 1991; 41(3): 165-171.
3. van der Mey AG, Frijns JH, Cornelisse CJ, Does intervention improve the natural course of glomus tumors? A series of 108 patients seen in a 32-year period. Ann Otol Rhinol Laryngol. 1992; 101(8): 635-642
4. Dessel T van, Frijns JHM, Wallenburg HCS. Prostaglandins and cervical dilatation, Fetal & Maternal Medicine Review. 1993; 5: 79-88. doi: 10.1017/S0965539500000760
5. Dessel T van, Frijns JHM, Kok FThJGTh, Wallenburg HCS. Ultrasound assessment of cervical dynamics during the first stage of labor, Eur.J.Obstet.Gynecol. & Reprod.Biol. 1994; 53(2): 123-127.
6. Frijns JHM, Wijngaarden A van, Peeters S. A multi-channel simultaneous data acquisition and waveform generator system designed for medical applications. J Med Eng Technol. 1994; 18(2): 54-60.
7. Frijns JHM, Mooij J, Kate JH. A quantitative approach to modelling mammalian myelinated nerve fibers for electrical prosthesis design. IEEE Trans Biomed Eng. 1994; 41(6): 556-566.
8. Frijns JHM, Kate JH. A Model of Myelinated Nerve Fibres for Electrical Prosthesis Design, Med.Biol.Eng.Comput. 1994; 32(4): 391-398.
9. Frijns JHM, Snoo SL de, Schoonhoven R. Potential distributions and neutral excitation patterns in a rotationally symmetric model of the electrically stimulated cochlea, Hear. Res. 1995; 87(1-2): 170-186. doi: 10.1016/0378-5955(95)00090-Q
10. Schoonhoven R, Prijs VF, Frijns JHM. Evidence for variability in strength across cochlear inner hair cell synapses, Progress in Biophysics & Molecular Biolog. 1996; 65(Suppl. 1): 201. doi: 10.1016/S0079-6107(97)80638-4
11. Frijns JHM. Computational Modelling of Electrical Stimulation of the Inner Ear. Acustica – Acta Acustica 1996; 82(Suppl. 1): 124.
12. Frijns JHM, Snoo SL de, ten Kate JH. Spatial selectivity in a rotationally symmetric model of the electrically stimulated cochlea. Hear Res. 1996; 95(1-2): 33-48
13. Schoonhoven R, Prijs VF, Frijns JHM. Transmitter release in inner hair cell synapses: a model analysis of spontaneous and driven rate properties of cochlear nerve fibres. Hear Res. 1997; 113(1-2): 247-260.
14. Frijns JH, Schoonhoven R. [The cochlea: modern physiologic insights into sensorineural hearing loss] (De cochlea: Slechthorendheid bezien vanuit moderne fysiologische inzichten.). Ned Tijdschr Geneeskd. 1998; 11;142(15): 830-836.
15. Frijns JHM, Briaire JJ, Schoonhoven R. Integrated Use of Volume Conduction and Neural Models to Simulate the Response to Cochlear Implants, Simpra. 2000; 8(1-2): 75-97.
16. Briaire JJ, Frijns JHM. 3D Mesh Generation to Solve the Electrical Volume Conduction Problem in the Implanted Inner Ear, Simpra 2000; 8 (1-2): 57-73doi: 10.1016/S0928-4869(00)00007-0
17. Briaire JJ, Frijns JHM. Field patterns in a 3D tapered spiral model of the electrically stimulated cochlea. Hear Res. 2000; 148(1-2): 18-30.
18. Langeveld APM, Drost HA, Frijns JHM, Zwinderman AH, Baatenburg de Jong RJ. Perceptual characteristics of adductor spasmodic dysphonia. Ann.Otol. Rhinol. Laryngol 2000; 109(8 pt 1): 741-748.
19. Frijns JHM, Snoo SL de, Schoonhoven R. Improving the accuracy of the boundary element method by the use of second-order interpolation functions. IEEE Trans Biomed Eng. 2000; 47(10): 1336-1346.
20. Mey AGL van der, Malessy MJ, et al. [Stereotaxic irradiation of vestibular schwannoma (acoustic neurinoma)] (Stereotactische bestraling van het vestibularisschwannoom (acusticusneurinoom). Ned Tijdschr Geneeskd. 2001; 145(4): 196-197.
21. Mey AGL van der, Malessy MJ, Frijns JHM, Grooters E. (2001) [Stereotaxic irradiation of vestibular schwannoma (acoustic neurinoma)] (Stereotactische bestraling van het vestibularisschwannoom), Ned. Tijdschr. KNO. 2001; 7(1): 5-6.
22. Frijns JHM, Briaire JJ, Grote JJ . The Importance of Human Cochlear Anatomy for the Results with Modiolus Hugging Multi-Channel Cochlear Implants. Otol.&Neurotol. 2001; 22(3): 340-349.
23. Frijns JHM, Briaire JJ, Laat JAPM de, Grote JJ. Initial evaluation of the Clarion CII cochlear implant: speech perception and neural response imaging (NRI), Ear Hear. 2002; 23(3): 184-197.
24. Frijns JHM, Klop WMC, Bonnet RM, Briaire JJ. Optimizing the number of electrodes with high-rate stimulation of the Clarion CII cochlear implant. Acta Otolaryngol 2003; 123(2): 138-142.
25. Haan TR de, Grooters E, Frijns JHM, Walther FJ. Unilateral supportive sialadenitis in a premature infant. Acta Paediatrica 2003; 92(12): 1491-1493.
26. Klop WMC, Hartlooper A, Briare JJ, Frijns JHM. A new method for dealing with the stimulus artefact in electrically evoked compound action potential measurements. Acta Otolaryngol. 2004; 124(2): 137-143.
27. Vanpoucke F, Zarowski A, Casselman J, Frijns JHM, Peeters S. The facial nerve canal: an important cochlear conduction path revealed by Clarion electrical field imaging. Otol Neurotol. 2004; 25(3): 282-289.
28. Bonnet RM, Mattie H, Laat, JAPM de, Schoemaker HC, Frijns JHM. Clinical ototoxicity of teicoplanin, Ann.Otol. Rhinol. Laryngol. 2004; 113(4): 310-312.
29. Bonnet RM, Frijns JHM, Peeters S, Briaire JJ. Speech Recognition with a Cochlear Implant using Triphasic Charge-balanced Pulses, Acta Otolaryngol. 2004; 124(4): 371-375.
30. Verbist BM, Frijns JHM, Geleijns J, van Buchem MA. Multisection CT as a valuable tool in the postoperative assessment of cochlear implant patients. AJNR Am J Neuroradiol. 2005; 26(2): 424-429.
31. Frijns-van Putten AAME, Beers M, Snieder SG, Frijns JHM Hearingtraining for adult CI-recipience: The Cochlear learning model (Hoortraining voor volwassen CI-dragers: Het cochleaire leermodel), Logopedie en Foniatrie. 2005; 77 (2): 50-59.
32. Briaire JJ, Frijns JHM. Unravelling the Electrically Evoked Compound Action Potential, Hear. Res. 2005; 205(1-2): 143-156.
33. Beek FB van der, Boermans PPBM, Verbist BM, Briaire JJ, Frijns JHM. Clinical Evaluation of the Clarion CII HiFocus 1 with and without Positioner. Ear Hear 2005; 26(6): 577-592.
34. Briaire JJ, Frijns JHM. The consequences of neural degeneration regarding optimal cochlear implant position in scala tympani: A model approach. Hear Res. 2006; 214(1-2):17-27.
Epub 2006 Mar 7.
35. Huisman MA, Heller S, Frijns JHM. [Damaged inner ear cells: Is a therapy on its way?] (Beschadigde binnenoorcellen: is er een therapie op komst?) Ned. Tijdschr KNO . 2006; 12(3): 139-143.
36. Dingemanse JG, Frijns JHM, Briaire JJ. Psychophysical assessment of spatial spread of excitation in electrical hearing with single and dual electrode contact maskers., Ear Hear. 2006; 27(6): 645-657.
37. Beek FB van der, Soede W, Frijns JHM. Evaluation of the Benefit for Cochlear Implantees of Two Assistive Directional Microphone Systems in an Artificial Diffuse Noise Situation, Ear Hear. 2007; 28(1): 99-110.
38. Laszig, R Chang SO, Kubo T, et al. APSCI Panel Discussion I: Imaging and Surgical Issues, Ear Hear 2007; 28 (2 Suppl): 119S-123S.
39. Frijns JHM. [Bilateral Cochlear Implantation: Fashion or form?] (Bilaterale Cochleaire Implantatie: Mode of must?) Ned. Tijdschr KNO. 2007; 13(2) :61-63.
40. Klop WMC, Briaire JJ, Stiggelbout AM, Frijns JHM. Cochlear implant outcomes and quality of life in adults with prelingual deafness, Laryngoscope. 2007; 117(11): 1982-1987.
41. Peek FA, Briare JJ, Mylanus EM, et al. [Postmeningitis deafness in young children: action warranted before obliteration of the cochlea]
42. Blom H, Lindenberg A, Frijns JHM [ENTER, the Next Step in the Development of an Education Plan] (ENTER, een volgende stap in de ontwikkeling van een opleidingsplan.). Ned. TijdschrKNO . 2007; 13 (4): 227- 232.
43. Ferrarini L, Verbist BM, Olofsen H, et al. Autonomous virtual mobile robot for three-dimensional medical image exploration: application to micro-CT cochlear images. Artif Intell Med. 2008; 43(1): 1-15. doi: 10.1016/j.artmed.2008.03.004
44. Klop WM, Boermans PP, Ferrier MB, van den Hout WB, Stiggelbout AM, Frijns JHM. Clinical relevance of quality of life outcome in cochlear implantation in postlingually deafened adults. Otol Neurotol. 2008; 29(5):615-21. doi: 10.1097/MAO.0b013e318172cfac.
45. Verbist BM, Joemai RM, Teeuwisse WM, Veldkamp WJ, Geleijns J, Frijns JHM. Evaluation of 4 multisection CT systems in postoperative imaging of a cochlear implant: a human cadaver and phantom study, Am J Neuroradiol. 2008; 29(7):1382-8. doi: 10.3174/ajnr.A1108.
46. El Seady R, Huisman MA, Löwik CW, Frijns JH. Uncomplicated differentiation of stem cells into bipolar neurons and myelinating glia. Biochem Biophys Res Commun. 2008; 376(2): 358-362. doi: 10.1016/j.bbrc.2008.08.166.
47. Frijns JHM, Kalkman RK, Vanpoucke FJ, Bongers JS, Briaire JJ. Simultaneous and non-simultaneous dual electrode stimulation in cochlear implants: evidence for two neural response modalities. ActaOtolaryngol. 2009; 129(4): 433-439. doi: 10.1080/00016480802610218.
48. Klop WMC, Frijns JHM, Soede W, Briaire JJ. An objective method to measure electrode independence in cochlear implant patients with a dual-masker forward masking technique. Hear Res. 2009; 253(1-2): 3-14. doi: 10.1016/j.heares.2009.03.006.
49. Verbist BM, Ferrarini L, Briaire JJ, et al. Anatomic considerations of cochlear morphology and its implications for insertion trauma in cochlear implant surgery. Otol Neurotol. 2009 ;30(4): 471-477. doi: 10.1097/MAO.0b013e3181a32c0d.
50. Frijns JH, Kalkman RK, Briaire JJ. Stimulation of the facial nerve by intracochlear electrodes in otosclerosis: a computer modeling study. Otol Neurotol. 2009 Dec;30(8):1168-74. doi: 10.1097/MAO.0b013e3181b12115.
51. Korver AM, de Vries JJ, Konings S, et al. DECIBEL collaborative study group. DECIBEL study: Congenital cytomegalovirus infection in young children with permanent bilateral hearing impairment in the Netherlands. J Clin Virol. 2009; 46(Suppl 4): S27-S31. doi: 10.1016/j.jcv.2009.09.007.
52. Tait M, Nikolopoulos TP, De Raeve L, et al. Bilateral versus unilateral cochlear implantation in young children. Int J Pediatr Otorhinolaryngol. 2010; 74(2): 206-211. doi: 10.1016/j.ijporl.2009.11.015.
53. Ambrosch P, Müller-Deile J, Aschendorff A, et al. European adult multi-centre HiRes® 120 study–an update on 65 subjects. Cochlear Implants Int. 2010; 11(Suppl 1) :406-411. doi: 10.1179/146701010X12671177204183.
54. Kania RE, Lamers GEM, Laar N van de, et al. Biofilms on tracheoesophageal voice prostheses: a confocal laser scanning microscopy demonstration of mixed bacterial and yeast biofilms. Biofouling. 2010; 26(5): 519-526. doi: 10.1080/08927014.2010.489238.
55. Verbist BM, Skinner MW, Cohen LT, et al. Consensus Panel on a Cochlear Coordinate System Applicable in Histologic, Physiologic, and Radiologic Studies of the Human Cochlea. Otol Neurotol. 2010; 31(5): 722-730. doi: 10.1097/MAO.0b013e3181d279e0.
56. Verbist BM, Joemai RMS, Briaire JJ, Teeuwisse WM, Veldkamp WJH, Frijns JHM. Cochlear coordinates in regard to cochlear implantation: a clinically individually applicable 3 dimensional CT-based method., Otol Neurotol. 2010; 31(5): 738-744. doi: 10.1097/MAO.0b013e3181d8d3c4.
57. Ketelaar L, Rieffe C, Otten-Koens JC, et al. Social emotions in deaf children with a CI between 1 and 5 years of age. Cochlear Implants Int. 2010; 11(Suppl. 1): 315-318. doi: 10.1179/146701010X12671177989516
58. Merkus P, Free RH, Mylanus EAM, Stokroos R, Metselaar M, Spronsen, van E, Grolman W, Frijns JHM. Dutch Cochlear Implant Group (CI-ON) consensus protocol on postmeningitis hearing evaluation and treatment. Otol Neurotol 2010; 31(8): 1281-1286. doi: 10.1097/MAO.0b013e3181f1fc58
59. Ruellan K, Frijns JHM, Bloemberg GV, et al. Detection of bacterial biofilm on cochlear implants removed because of device failure, without evidence of infection. Otol Neurotol 2010; 31(8): 1320-1324. doi: 10.1097/MAO.0b013e3181e3d36b.
60. Korver AMH, Konings S, Dekker FW, et al. Newborn hearing screening versus later hearing screening and developmental outcomes in children with permanent childhood hearing impairment, JAMA 2010; 304(15):1701-1708. doi: 10.1001/jama.2010.1501.
61. Carlyon RP, Macherey O, Frijns JHM, et al. Pitch comparisons between electrical stimulation of a cochlear implant and acoustic stimuli presented to a normal-hearing contralateral ear, J Assoc Res Otolaryngol. 2010; 11(4): 625-640. doi: 10.1007/s10162-010-0222-7.
62. Korver AMH, Admiraal RJC, Kant SG, et al. Causes of permanent childhood hearing impairment. Laryngoscope 2011; 121: 409–416. doi: 10.1002/lary.21377.
63. Snel-Bongers J, Briaire JJ, Vanpoucke FJ, Frijns JHM. Influence of widening electrode separation on current steering performance. Ear Hear 2011; 32( 2): 221-229. doi: 10.1097/AUD.0b013e3181f8c0fe.
64. Van Dijkhuizen JN, Beers M, Boermans PPBM, Briaire JJ, Frijns JHM. Measuring the intelligibility of adults with prelingual deafness to predict cochlear implant outcome. Ear Hear. 2011; 32(4): 445-458. doi: 10.3233/RNN-2010-0535
65. Frijns JHM, Dekker DMT, Briaire JJ. Neural excitation patterns induced by phased-array stimulation in the implanted human cochlea. Acta Otolaryngol. 2011; 131(4): 362-370. doi: 10.3109/00016489.2010.541939
66. Lawand NS, French PJ, Briaire JJ, Frijns JHM. Silicon Probes for Cochlear Auditory Nerve Stimulation and Measurement. Advanced Materials Research. 2011; 254: 82-85. doi: 10.4028/www.scientific.net/AMR.254.82
67. Van der Marel KS, Briaire JJ, Verbist BM, et al. Cochlear reimplantation with same device: surgical and audiological results. Laryngoscope. 2011; 121(7): 1517-1524. doi: 10.1002/lary.21722
68. Theunissen CPM, Rieffe C, Kouwenberg M, Soede W, Briaire JJ, Frijns JHM. Depression in hearing-impaired children. Int. J. Ped. Otolaryngol. 2011; 75(10): 1313-1317. doi: 10.1016/j.ijporl.2011.07.023.
69. Westen AA, Dekker DMT, Briaire JJ, Frijns JHM. Stimulus level effects on neural excitation and eCAP amplitude. Hear Res. 2011; 280: 166-176. doi: 10.1016/j.heares.2011.05.014.
70. Lawand NS, French PJ, Briaire JJ, Frijns JHM. Design and fabrication of silicon stiff probes: A step towards developed cochlear implant electrodes. Procedia Engineering. 2011; 25: 1012-1015. doi: 10.1016/j.proeng.2011.12.249
71. Boons T, Van Wieringen A, Brokx JPL, et al. Effect of pediatric bilateral cochlear implantation on language development. Arch Pediatr Adolesc Med. 2012; 166(1): 28-34. doi: 10.1001/archpediatrics.2011.748.
72. Büchner A, Lenarz Th, Boermans PPBM, Frijns JHM et al. Benefits of the HiRes 120 coding strategy combined with the Harmony processor in an adult European multicentre study. Acta Otolaryngol. 2012; 132(2): 179-187. doi: 10.3109/00016489.2011.630015.
73. Vanpoucke F, Boermans PPBM, Frijns JHM. Assessing the Placement of a Cochlear Electrode Array by Multidimensional Scaling, IEEE Trans Biomed Eng. 2012; 59(2): 307-310. doi: 10.1109/TBME.2011.2173198.
74. Theunissen CPM, Rieffe C, Kouwenberg M, Soede W, Briaire JJ, Frijns JHM. Anxiety in children with hearing aids or cochlear implants, compared to normally hearing controls, Laryngoscope. 2012; 122(3): 654-659. doi: 10.1002/lary.22502.
75. Snel-Bongers J, Briaire JJ, Vanpoucke FJ, Frijns JHM. Spread of excitation and channel interaction in single and dual electrode cochlear implant stimulation. Ear Hear. 2012; 33(3): 367-376. doi: 10.1097/AUD.0b013e318234efd5.
76. Beek van der FB, Briaire JJ, Frijns JHM. Effects of Parameter Manipulations on Spread of Excitation in Cochlear Implants Measured with ECAPs. Int J Audiol. 2012 June; 51(6): 465-474. doi: 10.3109/14992027.2011.653446
77. Van der Marel KS, Verbist BM, Briaire JJ, Joemai RMS, Frijns JHM. Electrode migration in cochlear implant patients: Not an exception, Audiol Neurotol. 2012; 17: 275-281. doi: 10.1159/000338475
78. Wiefferink CH, Rieffe C, Ketelaar L, Frijns JHM. Predicting social functioning in children with a cochlearimplant and in normal-hearing children: the role of emotion regulation Int J Pediatr Otorhinolaryngol. 2012; 76: 883-889. doi: 10.1016/j.ijporl.2012.02.065
79. Bonnet RM, Boermans PPBM, Avenarius OF, Briaire JJ, Frijns JHM. Effects of Pulse Width, Pulse Rate and Paired Electrode Stimulation on psychophysical measures of dynamic range and Speech Recognition in Cochlear Implants Ear Hear. 2012; 33(4): 489-496. doi: 10.1097/AUD.0b013e31824c761a.
80. Boons T, Brokx JPL, Frijns JHM, et al. Predictors of spoken language development following pediatric cochlear implantation. Ear Hear 2012; 33(5): 617-639.
81. Ketelaar L, Rieffe C, Wiefferink CH, Frijns JHM. Does hearing lead to understanding? Theory of mind development in Dutch toddlers and preschool children with cochlear implants J Pediatr Psychol. 2012; 37(9): 1041-1050.
82. Ketelaar L, Rieffe C, Wiefferink CH, Frijns JHM. Social competence and empathy in young children with cochlear implants and with normal hearing Laryngoscope 2013; 123(2): 518-523. doi: 10.1002/lary.23544
83. De Vries JJC, Vesseur A, Rotteveel LJC, et al. Cytomegalovirus DNA detection in dried blood spots and perilymphatic fluids from pediatric and adult cochlear implant recipients with prelingual deafness. J Clin Virol. 2013; 56(2): 113-117. doi: 10.1016/j.jcv.2012.10.008.
84. Wiefferink CH, Rieffe C, Ketelaar L, De Raeve L, Frijns JHM. Emotion understanding in children with a Cochlear Implant. J. Deaf Stud Deaf Educ. 2013; 18(2): 175-186. doi: 10.1093/deafed/ens042.
85. Frijns JHM, Snel-Bongers J, Vellinga D, Schrage E, Vanpoucke FJ, Briaire JJ. Restoring speech perception with cochlear implants by spanning defective electrode contacts. Acta Otolaryngol. 2013; 133(4): 394-399. doi: 10.3109/00016489.2012.754107
86. Locher H, de Rooij KE, de Groot JCMJ, et al. Class III β-tubulin, a novel biomarker in the human melanocyte lineage, Differentiation. 2013; 85(4-5): 173-181.
87. Lawand NS, Ngamkham W, Nazarian G, et al. An improved system approach towards future cochlear implants. Conf Proc IEEE Eng Med Biol Soc. 2013; 2013: 5163-5166. doi: 10.1109/EMBC.2013.6610711
88. Snel-Bongers J, Briaire JJ, Van Veen EH, Kalkman RK, Frijns JHM. Threshold levels of dual electrode stimulation in cochlear implants. J Assoc Res Otolaryngol. 2013; 14: 781-790. doi: 10.1007/s10162-013-0395-y
89. Locher H, Frijns JHM, van Iperen L, et al. Neurosensory development and cell fate determination in the human cochlea. Neural Dev. 2013; 8(1). doi: 10.1186/1749-8104-8-20.
90. Korver AMH, Konings S, Meuwese-Jongejeugd A, et al. National study of Newborn Hearing Screening: programme sensitivity and characteristics of undetected children, B-ENT. 2013; 9(Suppl. 21): 37-44.
91. Boons T, Brokx JPL, Frijns JHM, et al. Newborn hearing screening and cochlear implantation: impact on spoken language development, B-ENT. 2013; 9(Suppl 21): 91-98.
92. Lawand NS, Ngamkham W, Nazarian G, et al. An improved system approach towards future cochlear implants. Conf Proc IEEE Eng Med Biol Soc. 2013; 2013: 5163-5166. doi: 10.1109/EMBC.2013.6610711
93. Lenarz Th, James C, Cuda D, et al. European multi-centre study of the Nucleus Hybrid L24 cochlear implant, Int. J. Audiol. 2013; 52(12): 838-848. doi: 10.3109/14992027.2013.802032
94. Van der Marel KS, Briaire JJ, Wolterbeek R, Snel-Bongers J, Verbist BM, Frijns JHM. Diversity in cochlear morphology and the influence on CI electrode position. Ear Hear. 2014; 35(1): e9-e20. doi: 10.1097/01.aud.0000436256.06395.63.
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99. Kalkman RK, Dekker DMT, Briaire JJ, Frijns JHM. Place pitch versus electrode location in a realistic computational model of the implanted human cochlea, Hear Res. 2014; 315: 10-24. doi: 10.1016/j.heares.2014.06.003
100. Dekker DMT, Briaire JJ, Frijns, JHM. The impact of internodal segmentation in biophysical nerve fiber models. J. Comput. Neuroscience. 2014; 37(2): 307-315. doi: 10.1007/s10827-014-0503-y
101. Locher H, Frijns JHM, Huisman MA, Chuva de Sousa Lopes SM. TUBB3: Neuronal marker or melanocyte mimic? Cell Transplantation. 2014; 23: 1471-1473. doi: 10.3727/096368913X674099.
102. Van der Beek FB, Briaire JJ, Frijns JHM. Population-based prediction of fitting levels for individual cochlear implant recipients. Audiol. Neurotol. 2015; 20: 1-16. doi: 10.1159/000362779.
103. Van der Jagt MA, Brink WM, Versluis MJ, et al. Visualization of Human Inner Ear Anatomy with High Resolution Magnetic Resonance Imaging at 7 Tesla: initial clinical assessment, AJNR Am J Neuroradiol. 2015; 36(2): 378-383.
104. Van de Velde DJ, Dritsakis G, Frijns JHM, Van Heuven VJ, Schiller NO. The effect of spectral smearing on the discrimination of pure F0 intonation contours in vocoder simulations of cochlear implants. Cochl. Implants Int. 2015; 16(2): 77-87. doi: 10.1179/1754762814Y.0000000086
105. Kalkman RK, Briaire JJ, Frijns JHM. Current focusing in cochlear implants: An analysis of neural recruitment in a computational model. Hear Res. 2015; 322: 89-98. doi: 10.1016/j.heares.2014.12.004.
106. Netten AP, Rieffe C, Theunissen SCPM, et al. Low empathy in deaf or hard of hearing (pre)adolescents compared to normal hearing controls. PLOS One. 2015; 10(4): e0124102. doi: 10.1371/journal.pone.0124102
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108. Locher H, Saadah N, de Groot S, de Groot JMCJ, Frijns JHM, Huisman MA. Hair follicle bulge cultures yield class III β-tubulin-positive melanoglial cells. Histochem Cell Biol. 2015; 144: 87-91. doi: 10.1007/s00418-015-1312-8.
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111. Ketelaar L, Wiefferink CH, Frijns JHM, Broekhof E, Rieffe C. Preliminary findings on associations between moral emotions and social behavior in young children with normal hearing and with cochlear implants. Eur Child Adoles Psy. 2015. doi: : 10.1007/s00787-015-0688-2.
112. Van der Jagt MA, Brink WM, Webb AG, Frijns JHM, Verbist BM. Letter to the editor regarding In Vivo Imaging of the Inner Ear at 7T MRI: Image Evaluation and Comparison With 3T. Otol. Neurotol. 2015; 36(8): 1458-1459.
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