Jinghong Chen, PhD

Assistant Professor
Division of Gastroenterology (Visceral Pain Center)
Department of Internal Medicine
University of Texas Medical Branch at Galveston
Galveston, TX 77555, USA

Biography

EDUCATION

• 9/1995-9/1998: Ph.D. of Neuroscience specializing in neurophysiology Neurophysiology of Brain Research Institute in China Medical Univ
• 9/1988-7/1991: M.S. of Pharmacy specializing in Pharmacology Shenyang Pharmaceutical University, China
• 9/1981-7/1985: B.S. of Pharmacy specializing in pharmaceutics Pharmacy Department of Neimeng Medical University, China

PROFESSIONAL WORK HISTORY AND TEACHING EXPERIENCE:

• 1/2010-present: Assistant Professor, University of Texas Medical Branch, Department of Internal Medicine, in Galveston, Texas, Investigate for the molecular and cellular mechanism behind Gut-Brain axis activation, motility and behavioral changes; Central Neuromodulation of Gastrointestinal Pain Reflexes; inflammatory pain-related plasticity and gender differences
• 12/2006-1/2010: Research scientist in Pharmacology Research of Pharmacy at UT, M.D. Anderson Cancer Center for anticancer drugs pharmacology study
• 5/2002 -12/2006: Postdoctoral Fellow, Dept. of Anesthesiology & Pain Medicine at UT M.D. Anderson Cancer Center to study mechanism of neuropathic pain/ hyperalgesia and synaptic transmission using patch-clamp techniques, biochemical & behavioral methods
• 8/1998-4/2002: Postdoctoral Fellow, Beijing Institute of Pharmacology and Toxicology for Neuropharmacological pain research for visceral hyperalgesia and morphine tolerance8/1995-6/1991: Pharmacology group leader, Tianjin Amino Acid Therapeutic Co., China. Director for drug examination, research, develop new method
• 9/1988-7/1991: Teaching Assistant and Lecturer, Neimeng Medical College, China. • Teaching experience: Teaching college courses of pharmacology and pharmacological experiment, Neurophysiology (China Medical University), tutoring medical students

Research Interest

Her research interests include: Neurophysiology of visceral pain, Brain–Gastrointestinal Axis (Neuronal excitability, synaptic transmission and plasticity from inflammatory bowel disease); visceral hyperalgecia/pain and psychological stress, anxiety/ depression behavioral change; Gender differences or ion channels receptors in colon pain modulation.

Scientific Activities

MEMBERSHIP IN SCIENTIFIC SOCIETIES/PROFESSIONAL ORGANIZATIONS:

• Editorial Board member in Journal of Pain & Relief, JSM Gastroenterology and Hepatology
• Member of American Society of Neuroscience
• Member of American Society and Association for Study of Pain
• Member of Chinese Pharmacological Society
• The reviewer for the J Pain Res and BMC Medical Genomics

HONORS:

• Recipient of Servier Young Investigator Prize in Pharmacology awarded by the Institute de Researches Internationales Servier, France and Chinese Pharmacological Society, May 2002.
• Excellent English lecture award in the Chinese Young Pharmacologists Symposium. Chinese Pharmacological Society, Jan. 2002.
• Excellent paper award in the 4th East-West International Pain Conference. Apr. 2000.
• Excellent paper in Annual Academic Conference of Chinese Academy of Military Medical Science. Jan. 2001.
• Excellent PhD Dissertation, Oct. 2000.
• Excellent paper in the Annual Academic Conference of Chinese Academy of Military Medical Science. Jan. 1999
• Employee recognition award (MD Anderson Cancer Center), May 2008
• Editor’s review of Chinese Science Bulletin: A new evidence of pain specific theory from Dr. Chen (1998, 43: 1467~1471) for her important publishing in the journal.

Publications

PUBLISHED: https://www.researchgate.net/profile/JingHong_Chen/publications
PEER-REVIEWED JOURNALS:

1. Yuan S, Shi Y, Chen J, et al. Gp120 in the pathogenesis of human HIV-associated pain. Annals of Neurology. 2014; doi: 10.1002/ana.24139
2. Winston J, Chen J, Shi X-Z, Sarna SK. Inflammation induced by mast cell deficiency rather than the loss of interstitial cells of Cajal causes smooth muscle dysfunction in W/Wv mice. Frontiers. 2014; 5:22.
3. Chen J, Winston J, Sarna SK. Neurological and cellular regulation of visceral hypersensitivity induced by chronic stress and colonic inflammation. Neuroscience. 2013; 248C: 469-478. doi: 10.1016/j.neuroscience.2013.06.024
4. Chen J, Gong ZH, Yan H, Qin BY. Neuroplastic alteration of TTX-resistant sodium channel with visceral pain and morphine-induced hyperalgesia. J Pain Research. 2012; 5: 491-502 doi: 10.2147/JPR.S27751
5. Choi K, Chen J, Mitra S, Sarna SK. Impaired integrity of DNA after recovery from inflammation causes persistent dysfunction of colonic smooth muscle. Gastroenterology. 2011; 141(4): 1293-301. doi: 10.1053/j.gastro.2011.06.074
6. Chen J, Winston J, Sarna SK. Ulcerative Colitis-Like DSS Inflammation Primes Afferent Nerves to Exaggerate Visceral Hypersensitivity to Colorectal Distension by Chronic Stress. Gastroenterology. 2011; 140(5): S-535
7. Smith JA, Chen J, Gaikwad A, et al. Evaluation of letrozole for the prevention and inhibition of tumor growth in human cervical cancer xenograft mouse models. Cancer Prevention Research. 2011; 4(10): Suppl1: B78
8. Mach CM, Chen JH, Mosley SA, Kurzrock R, Smith JA. Evaluation of Liposomal curcumin cytochrome P450 metabolism. Anticancer Research. 2010; 3: 126-132.
9. Weng HR, Chen JH, Pan ZZ. Glial glutamate transporter 1 regulates the spatial and temporal coding of glutamatergic synaptic transmission in spinal lamina II neurons. Neuroscience. 2007; 149(4): 898-907. doi: 10.1016/j.neuroscience.2007.07.063
10. Chen JH, Saucier JM, Gaikwad A, Brown J, Smith JA. Evaluation of the impact of treatment delays and dose reductions in human ovarian cancer xenograft models. Reproductive Sciences. 2008; Suppl 15: Abs 860
11. Weng HR, Chen JH, Dougherty PM. Inhibition of glutamate uptake in the spinal cord induces mechanical hyperalgesia and increased responses of spinal dorsal horn neurons to peripheral afferent stimulation. Neuroscience. 2006; 138(4): 1351-1360. doi: 10.1016/j.neuroscience.2005.11.061
12. Cata JP, Weng HR, Chen JH, Dougherty PM. Altered discharges of spinal wide dynamic range neurons and down-regulation of glutamate transporter expression in rats with paclitaxel-induced hyperalgesia. Neuroscience. 2006; 138(1): 329-38. doi: 10.1016/j.neuroscience.2005.11.009
13. Chen JH, Liu Y, Gong ZH. Colitis pain model induced by colonic submucosal injection of bee venom in rats. Chin J Pharmacol & Toxicol. 2006; 20(1): 71-75.
14. Weng HR, Cata JP, Chen JH, Shaw AD, Dougherty PM. Spinal glial glutamate transporters downregulate in rats with taxol-induced hyperalgesia. Neurosci Lett. 2005; 386(1): 18-22. doi: 10.1016/j.neulet.2005.05.049
15. Chen JH, Weng HR, Dougherty PM. Sensitization of dorsal root reflexes in vitro and hyperalgesia in neonatal rats produced by capsaicin. Neuroscience. 2004; 126(3): 743- IF:2.88 doi: 10.1016/j.neuroscience.2004.04.021
16. Kong Q, Chen JH, Gong ZH. The effect on NG108-15 Ca+ concentration in morphine treatment of L-nitryl arginine methoester. Dizocilpine and Nifedipin Chinese Journal of Pharmacology and Toxicology. 2004; 18(4): 264-268.
17. Chen JH, Liu Y, Gong ZH. A new model of rat spinal DRG and dorsal horn neuron culture. Bulletin of the Academy of Military Medical Sciences. 2004; 28: 395-396.
18. Chen JH, Liu Y, Gong ZH, Qin BY. Related neural mechanisms between visceral hyperalgesia and morphine tolerance. Chinese Journal of Pharmacology and Toxicology. 2002; 16(5): 321-327.
19. Chen JH, Teng GX. Dye-coupling and gap-junction after intraneuronal injection of neurobiotin on the visceral nociceptive neurons in somatosensory cortex of cat. Neuroscience Bulletin. 2000; 16(1): 1-4.
20. Chen JH, Teng GX. Electrophysiological and morphological properties of nociceptive neurons. Chinese Journal of Pain Medicine. 2000; 6: 53-55.
21. Jinghong Chen, Teng GX. Characterization of Morphologies and Intracellular Responses of Somatosensory Cerebral Cortex Neurons to Noxious Visceral Stimulation in Cat. Brain Research Gene expression patterns. 1999; 846(2): 243-256.
22. Chen JH, Teng G X. Intracellular electrophysiological characteristics of visceral nociceptive neurons in cortex SI area of cats. Acta Physiologica Sinica. 1999; 51(1): 31-37.
23. Chen JH, Teng GX. Electrophysiological and morphological characteristics of visceral nociceptive neurons in cortex SII area of cat. Acta Physiologica Sinica. 1999; 51(4): 344-349.
24. Chen JH, Teng GX. Comparison of the membrane electrophysiological characteristics of the visceronociceptive and nor-nociceptive neurons in cortical SI area. Chinese science bulletin. 1998; 43(14): 1467-1471.
25. Chen JH and Teng GX. Sensation and conduction of visceral pain in central nervous system. Progress of Anatomical Sciences. 1998; 4(2): 119-126.
26. Chen JH, Teng G X. Membrane properties of the visceral nociceptive neurons in cortex SI area of cat. Acta Biophysica Sinica. 1998; 14(2): 282-288.
27. Chen JH, Liu CM, Wang QZ. The studies on the analgesic effect of the scorpion analgesic peptide(SAP). Chinese Journal of Pain Medicine. 1997; 4: 211-222.
28. Chen JH, Zhang RD, Ma XL, et al. Analgesic effect of scorpion venom(Buthus Martensii Karsch Liaonin) on visceral pain in cats. J Chin Med Univ. 1997; 16(4): 10-14.
29. Wang Q Z and Chen JH. The separate, purification and analgesic action of the scorpion analgesic peptide. J Shenyang Pharm Univ. 1994; 11(4): 273-277.
30. Chen JH. The physiological and pharmacological research of part renin-angiotensin system. Chin Pharma Bulletin. 1990. 6(6): 344-347.