Jieru Wang, MD, PhD

Assistant Professor of Pediatrics
Division of Pulmonary Medicine
Childrens Hospital of Pittsburgh of UPMC
University of Pittsburgh School of Medicine
9126 Rangos, 4401 Penn Ave
Pittsburgh, PA 15224, USA

Biography

Dr. Jieru Wang received her Medical and PhD degree from Central South University in China. The outbreaks of SARS and avian influenza awakened Dr. Wangs interest in respiratory medicine, she came to the United States pursuing her post-doc training in 2003. Under the mentorship of Dr. Robert Mason, a pioneer and expert in lung alveolar type II cells, Dr. Wang has received extensive and intensive training in lung cell biology at National Jewish Health. Dr. Wang has also gained expertise in respiratory viruses including influenza A virus and coronavirus through collaboration with the well-known experts in the field including Drs. Kathryn Holmes, David Wentworth, and Kevan Hartshorn. Recently Dr. Wang has received Parker B. Francis Fellowship Award, the prestigious Fellowship Award in the area of respiratory research, NIH funding, and start-up funding from University of Pittsburgh in study of influenza A viruses.
Since July 2013, Dr. Wang has established her laboratory in the Department of Pediatrics at University of Pittsburgh School of Medicine. Her lab mainly works on the primary respiratory cells, she has established the primary culture system in isolating and culturing human and mouse alveolar type II cells and Macrophages. Using primary culture system in combination with mouse models, Dr. Wangs group is trying to address how influenza virus impairs the alveolar epithelial barrier of the lung and how epithelial cell-immune cell interactions orchestrate innate immune response to the virus. In addition, she is also interested in how genetic and epigenetic factors affect individual response to respiratory pathogens.

Research Interest

Her research interests include: Lung Infection, Influenza, Pulmonary Inflammation and Immunity and Aging.

Scientific Activities

MEMBERSHIPS
• Full Member The American Association of Immunologist (2014-Present)
• Full Member American Thoracic Society (2011-2014)
• Full Member The American Physiology Society (2010-2011)
• Full Member American Society for Virology (2007-2010)
• Full member Sigma XI, the Scientific Research Society (2006-2007)
• Member International society of free radical biology and medicine, SFRBM (2005-2006)

Publications

PEER-REVIEWED PAPERS
1. Li L, Hamzeh N, Gillespie M, et al. Beryllium increases the CD14dimCD16+ subset in the lung of chronic beryllium disease. PLoS One. 2015; 10(2): e0117276. doi: 10.1371/journal.pone.0117276
2. Zhou B, Pearce MB, Li Y, et al. Asparagine substitution at PB2 residue 701 enhances the replication, pathogenicity and transmission of the 2009 pandemic H1N1 influenza A virus. PLoS One. 2013; 8(6): e67616. doi: 10.1371/journal.pone.0067616
3. Zhang W, Huang C, Gong Z, et al. Expression of LINC00312, a long intergenic non-coding RNA, is negatively correlated with tumor size but positively correlated with lymph node metastasis in nasopharyngeal carcinoma. J Mol Histol. 2013; 44(5): 545-554. doi: 10.1007/s10735-013-9503-x
4. Macleod MK, David A, Jin N, et al. Influenza nucleoprotein delivered with aluminium salts protects mice from an influenza A virus that expresses an altered nucleoprotein sequence. PLoS One. 2013; 8(4): e61775. doi: 10.1371/journal.pone.0061775
5. Qian Z, Travanty EA, Oko L, et al. Innate Immune Response of Human Alveolar Type II Cells Infected with SARS-Coronavirus. Am J Respir Cell Mol Biol. 2013; 48(6): 742-748. doi: 10.1165/rcmb.2012-0339OC
6. Wu Q, Case SR, Minor M, et al. A novel function of MUC18: amplification of lung inflammation during bacterial infection. Am J Pathol. 2013; 182(3): 819-827. doi: 10.1016/j.ajpath.2012.11.005
7. Kosmider B, Messier EM, Janssen WJ, et al. Nrf2 protects human alveolar epithelial cells against injury induced by influenza A virus. Respir Res. 2012; 13(1): 43. doi: 10.1186/1465-9921-13-43
8. Zhang W, Zeng Z, Fan S, et al. Evaluation of the prognostic value of TGF-β superfamily type I receptor and TGF-β type II receptor expression in nasopharyngeal carcinoma using high-throughput tissue microarrays. J Mol Histol. 2012. doi: 10.1007/s10735-012-9392-4
9. Wang J, Nikrad M, Travanty E, et al. Innate immune response of primary human alveolar macrophages during influenza A infection. PLoS ONE. 2012; 7(3): e29879. doi: 10.1371/journal.pone.0029879
10. Funk CJ, Wang J, Ito Y, et al. Infection of human alveolar macrophages by coronavirus 229E. J Gen Virol. 2012; 93(3): 494-503. doi: 10.1099/vir.0.038414-0
11. Watanabe T, Shinya K, Watanabe S, et al. Avian-type receptor-binding ability can increase influenza virus pathogenicity in macaques. J Virol. 2011; 85(24): 13195-13203. doi: 10.1128/JVI.00859-11
12. Yu WC, Chan RW, Wang J, et al. Viral replication and innate host responses in primary human alveolar epithelial cells and alveolar macrophages infected with influenza H5N1 and H1N1 viruses. J Virol. 2011; 85(14): 6844-6855. doi: 10.1128/JVI.02200-10
13. Macleod MK, McKee AS, David A, et al. Vaccine adjuvants aluminum and monophosphoryl lipid A provide distinct signals to generate protective cytotoxic memory CD8 T cells. Proc Natl Acad Sci USA. 2011; 108(19): 7914-7919. doi: 10.1073/pnas.1104588108
14. Wang J, Nikrad M, Phang T, et al. Innate immune response to influenza A virus in differentiated human alveolar type II cells. Am J Respir Cell Mol Biol. 2011; 45(3): 582-591. doi: 10.1165/rcmb.2010-0108OC
15. Wang J, Oberley-Deegan R, Wang S, Funk CJ, Hartshorn KL, Mason RJ. Differentiated human alveolar type II cells secrete antiviral IL-29 (IFN-lambda 1) in response to influenza a infection. J Immunol. 2009; 182(3): 1296-1304.
16. Mossel E, Wang J, Jeffers S, et al. SARS-CoV replicates in primary human alveolar type II cell cultures but not in type I-like cells. Virology. 2008; 372(1): 127-135. doi: 10.1016/j.virol.2007.09.045
17. Miura TA, Wang J, Holmes K, Mason RJ. Rat coronaviruses infect rat alveolar type I epithelial cells and induce expression of CXC chemokines. Virology. 2007; 369(2): 288-298. doi: 10.1016/j.virol.2007.07.030
18. Wang J, Edeen K, Manzer R, et al. Differentiated human alveolar epithelial cells and reversibility of their phenotype in vitro. Am J Respir Cell Mol Biol. 2007; 36(6): 661-668. doi: 10.1165/rcmb.2006-0410OC
19. Wu M, Wang J, Li G. Progression of molecular genetics in primary brain tumor. International Journal of Pathology and Clinical Medicine. 2007; 27(3): 9-226.
20. Wang J, Wang S, Manzer R, McConville G, Mason RJ. Ozone induced oxidative stress in rat alveolar epithelial cells. Free Radic Biol Med. 2006; 40(11): 1914-1928.
21. Manzer R, Wang J, Nishina K, McConville G, Mason RJ. Alveolar epithelial cells secrete chemokines in response to IL-1beta and lipopolysaccharide but not to ozone. Am J Respir Cell Mol Biol. 2006; 34(2): 158-166. doi: 10.1165/rcmb.2005-0205OC
22. Miura TA, Wang J, Mason RJ, Holmes K. Rat coronavirus infection of primary rat alveolar epithelial cells. Adv Exp Med Biol. 2006; 58: 351-356.
23. Chang YS, Wang J, Lu XJ, Thewke DP, Mason RJ. KGF induces lipogenic genes through a P13K and JNK/SREBP-1 pathway in H292 cells. J Lipid Res. 2005; 46(12): 2624-2635.
24. Nishina K, Zhang F, Nielsen L, Wang J, Mason RJ. Expression of CINC-2 beta is related to the status of differentiation of alveolar epithelial cells. Am J Respir Cell Mol Biol. 2005; 33(5): 505-512.
25. Fan SQ, Wang JR, Huang H, et al. Function of a novel brain-specific gene LRRC4. Zhonghua Zhong Liu Za Zhi. 2005; 27(7): 393-396.
26. Zhang Q, Wang J, Fang S, et al. Expression and functional characterization of LRRC4, a novel brain-specific member of the LRR superfamily. FEBS Lett. 2005; 579(17): 3674-3682. doi: 10.1016/j.febslet.2005.05.058
27. Zhang QH, Wang LL, Peng C, et al. Establishment of brain relatively specific gene LRRC4 with doxycycline induced Tet regulating system in U251 glioma cell line. Prog Biochem Biophys. 2005; 32(4): 325-330.
28. Zhang QH, Wang LL, Cao L, et al. Study of a novel brain relatively specific gene LRRC4 involved in glioma tumorigenesis suppression using the Tet-on system. Acta Biochim Biophys Sin (Shanghai). 2005; 37(8): 532-540. doi: 10.1111/j.1745-7270.2005.00079.x
29. Zhang XM, Sheng SR, Wang XY, Bin LH, Wang JR, Li GY. Expression of tumor related gene NAG6 in gastric cancer and restriction fragment length polymorphism analysis. World J Gastroenterol. 2004; 10(9): 1361-1364.
30. Xiong W, Zeng ZY, Xia JH, et al. Susceptibility locus at chromosome 3p21 linked to familial nasopharyngeal carcinoma. Cancer Res. 2004; 64(6): 1972-1974. doi: 10.1158/0008-5472.CAN-03-3253
31. Wang JR, Li X, Fan SQ, et al. Expression of LRRC4 in the U251glioblastoma cell line correlates with the decrease rate and tumorigenic potential. Ai Zheng. 2003; 22(9): 897-902.
32. Zhang XM, Sheng SR, Wang XY, Wang JR, Jiang L. Expression of tumor related genes NGX6, NAG-7, BRD7 in gastric and colorectal cancer. World J Gastroenterol. 2003; 9(8): 1729-1733.
33. Fan SQ, Zhou M, Xiang Q, et al. In situ expression of connexins in various carcinomas. Ai Zheng. 2003; 22(6): 686-690.
34. Wang JR, Dong L, Tan C, Li XL, Li GY. Molecular cloning and sequence character of a glial-specific gene, LRRC4, downregulated in brain tumors. Chinese Cancer Research Progress. 2002; 29(6): 426-433.
35. Zeng ZY, Xiong W, Li XL, Wang JR, Li GY. Establishment of literature database of nasopharyngeal carcinoma (NPC) related gene. Chinese Journal of Cancer. 2002, 21(9): 1026-1028.
36. Wang JR, Dong L, Li GY. Preliminary Study of LRRC4 Protein: Bioinformatics Analysis, Fusion Expression and Localization. Prog.Biochem. Biophys. 2002; 29(5): 696-701.
37. Tan C, Li J, Wang J, et al. Proteomic analysis of differential protein expression in human nasopharyngeal carcinoma cells induced by NAG7-transfection. Proteomics. 2002, 2(2): 306-312. doi: 10.1002/1615-9861(200203)2:3<306::AID-PROT306>3.0.CO;2-23
38. Qian J, Zhang XM, Li XL, et al. Identification of digital differential expression patterns of a novel human gene (UBAP1) by an expressed sequence tag strategy. Ai Zheng. 2002; 21(3): 225-228.
39. Wang JR, Qian J, Dong L, et al. Identification of LRRC4, a novel member of leucine-rich repeat (LRR) super family, and its expression analysis in brain tumor. Prog. Biochem. Biophys. 2002; 29(2): 233-239.
40. Xiang JJ, Yu Y, Wang JR, Li GY. Identification and characterization of a nasopharyngeal carcinoma (NPC) related gene, which shows the hallmark characteristics of a processed pseudogene. Prog. Biochem Biophys. 2002; 29(1): 51-55.
41. Qian J, Yang J, Zhang X, Zhang B, Wang J, Li GY. Isolation and characterization of a novel cDNA , UBAP1, derived from the tumor suppressor locus in human chromosome. J Cancer Res Clin Oncol. 2001; 127(10): 613-618.
42. Li J, Tan C, Xiang Q, et al. Proteomic detection of changes in protein synthesis induced by NGX6 transfection in human nasopharyngeal carcinoma cells. J Pro Chem. 2001; 20(3): 265-271.
43. Tan C, Li J, Wang JR, Li GY. Identification and significance of down-regulated proteins in HNE1 cells transfected with NAG7. Chin J Biochem Mol Biol. 2001; 17(6): 688-693.
44. Wang JR, Bin LH, Qian J, Zhang XH, Li GY. Preliminary study of a novel gene negatively associated with nasopharyngeal carcinoma on chromosome 7q31-32. Chin J Cancer. 2001; 20(7): 688-691.
45. Li J, Tan C, Xiang Q, et al. Preliminary function study of a putative tumor suppressor gene in human nasopharyngeal carcinoma cells using two-dimensional electrophoresis and mass spectrometry. Chinese Journal of Cancer. 2001, 20(7): 692-695.
46. Qian J, Zhang XH, Yang JB, et al. Cloning and expression analysis of a novel gene, UBAP1, possibly involved in ubiquitin pathway. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai). 2001; 33(2): 147-152.
47. Zhang XH, Qian J, Wang JR, Bin L, Li GY. Cloning of a novel putative tumor suppressor gene associated with nasopharyngeal carcinoma on the smallest common deletion region of 7q32-ter. Chin J Cancer. 2000; 19(11): 961-965.
48. Tan C, Li J, Xie Y, et al. Preliminary function study of NAG7 using two dimensional electrophoresis and mass spectrometry. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai). 2001; 33(4): 373-378.
49. Wang JR, Zhou J, Tan HZ. An epidemiological investigation on behavioral problem among school children in flood district. Chinese Journal of Disease Control and Prevention. 1999; 3(4): 268-270.
50. Tan HZ, Liu AZ, Wang JR, Li SQ. A multiple variable analysis about the risk factors of breast cancer in women. Bull of Hunan Med Univ. 1998; 23(4): 365-368.
51. Yang TB, Xiao XL, Wang JR, Tan HZ. A comparative study on the risk factors for the incidence of tongue cancer. Bull of Hunan Med Univ. 1998; 23(2): 141-142.
52. Liu AZ, Tan HZ, Wang JR, Li SQ. Case control study on 153 paired patients with colon cancer. Chinese Journal of Public Health. 1997; 13(3): 242-244.
BOOK CHAPTER
1. Wang JR. Statistical Consideration for Analysis of Nosocomial Infection Data. Nosocomial Infection. Hunan Science and Technology Press, Changsha. 1998; 172-190.