Jian Pan, PhD


Associate Professor
Department of Hematology and Oncology
Childrens Hospital of Soochow University
303 Jingde Rd, Ping Jiang Qu, Suzhou, Jiangsu
China

Biography

Education:

•(2001-2005) B.Sc. Biology , NanJing University, Jiansu Province, PR China
•(2005-2010) Ph.D. Immulogy, State Key Laboratory of Molecular Oncology, Cancer Institute (Hospital), Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, PR China

Experience:

•(2010- Present) Associate professor, Department of Hematology and Oncology, Childrens Hospital of Soochow University, Suzhou, China
•(2010-Present) A guest professor of Translational Research Center, Second Hospital, The Second Clinical School, Nanjing Medical University, Nanjing, China
•8 years of extensive experiences in molecular oncology, hematology, leukemia and cell biologically associated research

Research Interest

His research interests include: Molecular oncology, hematology, leukemia and cell biologically associated research.

Scientific Activities

Publications

1. Wang NN, Li ZH, Zhao H, et al. Molecular Targeting of the Oncoprotein PLK1 in Pediatric Acute Myeloid Leukemia: RO3280, a Novel PLK1 Inhibitor, Induces Apoptosis in Leukemia Cells. International journal of molecular sciences. 2015; 16: 1266-1292. doi:10.3390/ijms16011266
2. Tao YF, Xu LX, Lu J, et al. Early B-cell factor 3 ( EBF3 ) is a novel tumor suppressor gene with promoter hypermethylation in pediatric acute myeloid leukemia. J Exp Clin Cancer Res. 2015; 34: 4. doi:10.1186/s13046-014-0118-1
3. Xu L, Li Z, Tao Y, et al. Histone acetyltransferase inhibitor II induces apoptosis in glioma cell lines via the p53 signaling pathway. J Exp Clin Cancer Res 2014; 33: 108. doi:10.1186/s13046-014-0108-3
4. Pang L, Liang Y, Pan J, Wang JR, Chai YH, Zhao WL. Clinical Features and Prognostic Significance of TCF3-PBX1 Fusion Gene in Chinese Children with Acute Lymphoblastic Leukemia by Using a Modified ALL-BFM-95 Protocol. Pediatric hematology and oncology. 2014. doi:10.3109/08880018.2014.983625
5. Cao L, Wang N, Pan J, et al. Effect of DNA methylation on the proliferation of leukemia cells regulated by miR-34b. Zhonghua er ke za zhi. Chinese journal of pediatrics. 2014; 52: 840-845.
6. Tao YF, Li ZH, Wang NN, Fang F, Xu LX, Pan J. Tp53-dependent G2 arrest mediator candidate gene, Reprimo, is down-regulated by promoter hypermethylation in pediatric acute myeloid leukemia. Leukemia & lymphoma 2015; 1-14. doi:10.3109/10428194.2015.1011157
7. Wu SY, Fan J, Hong D, et al. C3aR1 gene overexpressed at initial stage of AML-M2 patients predicting a short term survival. Leukemia & lymphoma 2014; 1-7. doi:10.3109/10428194.2014.986481
8. Tao YF, Xu LX, Lu J, et al. Metallothionein III (MT3) is a putative tumor suppressor gene that is frequently inactivated in pediatric acute myeloid leukemia by promoter hypermethylation. Journal of translational medicine 2014; 12: 182. doi: 10.1186/1479-5876-12-182
9. Tao YF, Hu SY, Lu J, et al. Zinc finger protein 382 is downregulated by promoter hypermethylation in pediatric acute myeloid leukemia patients. International journal of molecular medicine 2014; 34: 1505-1515. doi:10.3892/ijmm.2014.1966
10. Ma W, Zhang T, Pan J, et al. Assessment of insulin-like growth factor 1 receptor as an oncogene in esophageal squamous cell carcinoma and its potential implication in chemotherapy. Oncology reports 2014; 32: 1601-1609. doi:10.3892/or.2014.3348
11. Fang F, Pan J Xu L, Su G, Li G, Wang J. Association between angiotensin-converting enzyme gene insertion/deletion polymorphism and pancreatitis risk: A meta-analysis. Journal of the renin-angiotensin-aldosterone system : JRAAS. 2014; pii: 1470320314539827. doi: 10.1177/1470320314539827
12. Yan-Fang T, Jian N, Jun L, et al. The promoter of miR-663 is hypermethylated in Chinese pediatric acute myeloid leukemia (AML). BMC medical genetics 2013; 14: 74. doi:10.1186/1471-2350-14-74
13. Wang N, Pan J, Cao L, et al. The expression and clinical significance of miR-203 in pediatric acute leukemia. Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 2013; 34:777-781. doi:10.3760/cma.j.issn.0253-2727.2013.09.009
14. Tao YF, Pang L, Du XJ, et al. Differential mRNA expression levels of human histone-modifying enzymes in normal karyotype B cell pediatric acute lymphoblastic leukemia. International journal of molecular sciences 2013; 14: 3376-3394. doi:10.3390/ijms14023376
15. Sun L, Chen L, Pan J, et al. Functional Screen for Secreted Proteins by Monoclonal Antibody Library and Identification of Mac-2 Binding Protein (Mac-2BP) as a Potential Therapeutic Target and Biomarker for Lung Cancer. Molecular & cellular proteomics : MCP 2013; 12: 395-406. doi:10.1074/mcp.M112.020784
16. Li Y, Yan J Li M, et al. Addition of SNAP to perinatal risk factors improves the prediction of bronchopulmonary dysplasia or death in critically ill preterm infants. BMC pediatrics 2013; 13: 138. doi:10.1186/1471-2431-13-138
17. Li Y, Xiao Z, Yan J, et al. Urine erythropoietin level is associated with kidney and brain injury in critically ill neonates. Neonatology 2013; 104: 87-94. doi:10.1159/000350546
18. Li Y, Li X, Zhou X, et al. Impact of sepsis on the urinary level of interleukin-18 and cystatin C in critically ill neonates. Pediatr Nephrol 2013; 28: 135-144. doi:10.1007/s00467-012-2285-7
19. Hu S, Wang Y, Wu S, et al. Homology modeling and molecular dynamics studies of Wilms tumor gene 1 frameshift mutations in exon 7. Biomedical reports 2013; 1: 702-706. doi:10.3892/br.2013.149
20. Zhao WL, Nie SS, Xu YY, et al. Expression of two subtype molecules of CD133 in childhood with B linage acute lymphoblastic leukemia and its clinical significance. Zhongguo shi yan xue ye xue za zhi / Zhongguo bing li sheng li xue hui = Journal of experimental hematology / Chinese Association of Pathophysiology 2012; 20: 536-540. doi:
21. Yan-Fang T, Dong W, Li P, et al. Analyzing the gene expression profile of pediatric acute myeloid leukemia with real-time PCR arrays. Cancer Cell Int 2012; 12: 40. doi:10.1186/1475-2867-12-40
22. Wen-Li Z, Jian W, Yan-Fang T, et al. Inhibition of the ecto-beta subunit of F1F0-ATPase inhibits proliferation and induces apoptosis in acute myeloid leukemia cell lines. J Exp Clin Cancer Res 2012; 31: 92. doi:10.1186/1756-9966-31-92
23. Tao YF, Lu J, Du XJ, et al. Survivin selective inhibitor YM155 induce apoptosis in SK-NEP-1 Wilms tumor cells. BMC cancer 2012; 12: 619. doi: 10.1186/1471-2407-12-619
24. Sun L, Pan J, Peng L, et al. Combination of haptoglobin and osteopontin could predict colorectal cancer hepatic metastasis. Annals of surgical oncology 2012; 19: 2411-2419. doi:10.1245/s10434-011-2177-2
25. Jian P, Yan WS, Chao SL, et al. Promoter of TFPI-2 is hypermethylated in Chinese pediatric acute myeloid leukemia. Journal of pediatric hematology/oncology 2012; 34: 43-46. doi:10.1097/MPH.0b013e3182277276
26. Sun L, Hu H, Peng L, et al. P-cadherin promotes liver metastasis and is associated with poor prognosis in colon cancer. The American journal of pathology 2011; 179: 380-390. doi:10.1016/j.ajpath.2011.03.046
27. Pan J, Tao YF, Zhou Z, et al. An novel role of sphingosine kinase-1 (SPHK1) in the invasion and metastasis of esophageal carcinoma. Journal of translational medicine 2011; 9: 157. doi:10.1186/1479-5876-9-157
28. Pan J, Sun LC, Tao YF, et al. ATP synthase ecto-alpha-subunit: a novel therapeutic target for breast cancer. Journal of translational medicine 2011; 9: 211. doi:10.1186/1479-5876-9-211
29. Jian P, Yanfang T, Zhuan Z, Jian W, Xueming Z, Jian N. MMP28 (epilysin) as a novel promoter of invasion and metastasis in gastric cancer. BMC cancer 2011; 11: 200. doi:10.1186/1471-2407-11-200
30. Jian P, Li ZW, Fang TY, et al. Retinoic acid induces HL-60 cell differentiation via the upregulation of miR-663. Journal of hematology & oncology 2011; 4: 20. doi:10.1186/1756-8722-4-20
31. Pan J, Hu H, Zhou Z, et al. Tumor-suppressive mir-663 gene induces mitotic catastrophe growth arrest in human gastric cancer cells. Oncology reports 2010; 24: 105-112. doi:10.3892/or_00000834
32. Ran Y, Pan J, Hu H, et al. A novel role for tissue factor pathway inhibitor-2 in the therapy of human esophageal carcinoma. Hum Gene Ther 2009; 20: 41-49. doi:10.1089/hum.2008.129
33. Peng L, Ran YL, Hu H, et al. Secreted LOXL2 is a novel therapeutic target that promotes gastric cancer metastasis via the Src/FAK pathway. Carcinogenesis 2009; 30: 1660-1669. doi:10.1093/carcin/bgp178
34. Hu H, Sun L, Guo C, et al. Tumor cell-microenvironment interaction models coupled with clinical validation reveal CCL2 and SNCG as two predictors of colorectal cancer hepatic metastasis. Clinical cancer research : an official journal of the American Association for Cancer Research 2009; 15: 5485-5493. doi:10.1158/1078-0432.CCR-08-2491
35. Hu H, Ran Y, Zhang Y, et al. Antibody library-based tumor endothelial cells surface proteomic functional screen reveals migration-stimulating factor as an anti-angiogenic target. Molecular & cellular proteomics : MCP 2009; 8: 816-826. doi:10.1074/mcp.M800331-MCP200
36. Zhou Z, Ran YL, Hu H, et al. TM4SF3 promotes esophageal carcinoma metastasis via upregulating ADAM12m expression. Clin Exp Metastasis 2008; 25: 537-548. doi:10.1007/s10585-008-9168-0
37. Ran Y, Hu H, Zhou Z, et al. Profiling tumor-associated autoantibodies for the detection of colon cancer. Clinical cancer research : an official journal of the American Association for Cancer Research 2008; 14: 2696-2700. doi:10.1158/1078-0432.CCR-07-2021
38. Ran Y, Hu H, Hu D, et al. Derlin-1 is overexpressed on the tumor cell surface and enables antibody-mediated tumor targeting therapy. Clinical cancer research : an official journal of the American Association for Cancer Research 2008; 14: 6538-6545. doi: 10.1158/1078-0432.CCR-08-0476