Javier Triñanes, PhD


Postdoctoral Researcher
Division of Nephrology
Department of Internal Medicine
Leiden University Medical Center
The Netherlands

Biography

Education and training

2009-2013
University of La Laguna
Biomedical research: cardiovascular complications of kidney disease and diabetes. Doctorate (PhD) in Biomedical Sciences

2008-2009
University of La Laguna
Master (MSc) Degree in Biomedicine

2001-2006
University of La Laguna
Bachelor (BSc) in Biology: with the specialties of Molecular Biology and Public Health Biology

Research Interest

Post-transplant diabetes in kidney receptors, Vascular complications after kidney transplantation, Mechanisms by which immunosuppressive drugs affect glucose homeostasis in kidney recipients and the consequences that this may have on graft and patient survival, Mechanisms of diabetes-induced vascular damage, Activation of cytokines and adhesion molecules in the artery wall.

Scientific Activities

Work experience

February 2016 to present
Postdoctoral researcher at Leiden University Medical Center. Department of Medicine. Division of Nephrology.

April 2015 – November 2015
Postdoctoral researcher at Centro de InvestigacionesBiomédicas de Canarias (Center for Biomedical Research of the Canary Islands) (CIBICAN), University of La Laguna, Tenerife, Spain.

June 2012 – December 2014
Research assistant at the Research Unit of the University Hospital of the Canary Islands, Tenerife, Spain.

February 2008 – December 2012
PhD student at the Research Unit of the University Hospital of the Canary Islands, Tenerife, Spain.

Grants and awards

1. Research grant for doctoral studies founded by the Spanish Ministry of Education and Culture to develop the research “Cardiovascular complications after kidney transplantation: risk factors and molecular mechanisms” in the University Hospital of the Canary Islands. 2008
2. Health Research grant, founded by Instituto de Salud Carlos III (Health Institute Carlos III) and the Spanish Ministry of Health, for the development of the research: “Alterations in glucose homeostasis after kidney transplantation”. 2012
3. Iñigo Alvarez de Toledo Nephrology Research Awards for the scientific article “Type 1 Diabetes Mellitus Increases the Expression of Pro-inflammatory Cytokines and Adhesion Molecules in the Artery Wall of Candidate Patients for Kidney Transplantation”. Diabetes Care. 2012.
4. Albert Renold Travel Fellowship by the European Foundation for the Study of Diabetes (EFSD). For the learning of the surgical techniques to perform the transplantation of human islets under the kidney capsule of mice in the Leiden University Medical Centre. 2015
5. Travel Grant by the European Society of Organ Transplantation (ESOT). For the learning of the surgical techniques to perform the transplantation of human islets under the kidney capsule of mice in the Leiden University Medical Centre. 2015
6. Innovation Grant by the Dutch Kidney Foundation. For the development of the research project: “Novel possibilities for post-transplant diabetes: does an insulin resistant milieu modulate Tacrolimus-activated TGF-beta signaling for dedifferentiation of beta-cells?”. 2016

Publications

1. Triñanes J, Rodriguez-Rodriguez AE, Brito Y, Wagner A, De Vries APJ, CuestoG,Acebes A, Salido E, Torres A, Porrini E. Deciphering tacrolimus-induced toxicity in pancreatic β-cells. Am J Transplant. 2017 Apr 22. doi: 10.1111/ajt.14323.
2. Domingo Hernández, Javier Triñanes, Ana MaríaArmas, Pedro Ruiz-Esteban, Juana Alonso-Titos, Ana Duarte, Miguel González-Molina, Eulalia Palma, Eduardo Salido and Armando Torres. Vascular Damage and Kidney Transplant Outcomes: An Unfriendly and Harmful Link. The American Journal of the Medical Sciences, http://dx.doi.org/10.1016/j.amjms.2017.01.004
3. Gimeno-García AZ, Triñanes J, Quintero E, Salido E, Nicolás-Pérez D, Adrián-de-Ganzo Z, Alarcón-Fernández O, Abrante B, Romero R, Carrillo M, Ramos L, Alonso I, Ortega J, Jiménez A. Plasma matrix metalloproteinase 9 as an early surrogate biomarker of advanced colorectal neoplasia. GastroenterolHepatol. 2015 Nov 18. pii: S0210-5705(15)00242-3.
4. Rodriguez-Rodriguez AE, Triñanes J, Porrini E, Velazquez-García S, Fumero C, Vega-Prieto MJ, Diez-Fuentes ML, Salido E, Torres A. Changes in glucose homeostasis and pancreatic beta cell after switching to Cyclosporine in diabetes induced by Tacrolimus. Nefrología. 2015. 35(3):264-72.
5. Hernandez D*, Triñanes J*, Salido E, Rufino M, Gonzalez-Posada JM, Torres A. Artery wall assessment helps predict kidney transplant outcome. PLoS One. 2015. Jun 12;10(6):e0129083. *Combined first author.
6. Rodriguez-Rodriguez AE*, Triñanes J*, Velazquez-García S*, Porrini E, Vega-Prieto MJ, Diez-Fuentes ML, Arévalo M, Salido E, Torres A. The Higher Diabetogenic Risk of Tacrolimus Depends on Pre-Existing Insulin Resistance. A Study in Obese and Lean Zucker Rats. Am J Transplant. 2013. Jul;13(7):1665-75 *Combined first author.
7. Triñanes J, Salido E, Fernandez J, Rufino M, Gonzalez-Posada JM, Torres A, Hernández D. Type 1 Diabetes Mellitus Increases the Expression of Pro-inflammatory Cytokines and Adhesion Molecules in the Artery Wall of Candidate Patients for Kidney Transplantation. Diabetes Care. 2012. 35:427-433.