Comments on Acute Pancreatitis’ Progression Hypotheses to Chronic Pancreatitis

Abstract

From our experience and several research studies, acute pancre
atitis (AP) progression to chronic pancreatitis (CP) is a com
plex issue in the medical field. The progression was hypothesized 
many years ago but still, many controversies are not clarified in the 
present literature. 
CP is a well-known invaliding disease that causes a sensi
tive decrease in life expectancy. This pathology is associated with 
several genetic alterations that can provoke morphological abnor
malities.1
 On the other hand, AP is a syndrome (and it must be 
considered more a systemic than confined pathology) caused by 
the release of pancreatic enzymes into the bloodstream and sub
sequent activation of systemic inflammatory systems (as comple
ments).2