Ibrahim M. EL-Sherbiny, PhD

Associate Professor of Nanoscience
Director of Center for Nanomaterials Science
The University of Science and Technology
Zewail City, Egypt

Biography

• Dr. Ibrahim M. El-Sherbiny earned his PhD degree in Drug Delivery in February 2007 from Massey University, New Zealand.
• From 2008 to 2010, he joined pharmaceuticals research groups as a post-doctoral fellow at the University of New Mexico, USA and Texas University, USA.
• Dr. El-Sherbiny’s academic acumen has been recognized by being offered a “Fulbright Fellowship” at the University of Michigan, Biomedical Engineering in 2009 and he has also awarded the prestigious “Egyptian State Incentive Award in Science” in 2012, and the “Venice Kamel Award for Scientific Creativity for Young Researchers in the field of Materials Science and its Applications” in 2013.
• From 2010-2011, he worked as Research Assistant Professor in the College of Pharmacy at the University of Texas, USA. He is currently holding the position of Associate Professor of Nanomaterials Science and Director of the Center for Materials Science at Zewail City of Science and Technology, Egypt.
• Dr. El-Sherbiny’s research focuses in particular on the design and development of new classes of “smart nano- and nano-in-micro- polymeric matrices” using advanced techniques, and evaluating these new structures as potential candidates in various biomedical applications including targeted drug delivery, sustained pulmonary drug release, tissue engineering and regenerative medicine.
• Dr. El-Sherbiny has about fifty peer-reviewed scientific papers, about same number of participations in international conferences. He the author of two books, seven book chapters, and several review articles. Besides, he is also a named inventor on eleven patents and patents applications in USA (4), UK (4), Europe (1) and Egypt (2).
• Dr. El-Sherbiny is a member of several scientific societies such as American Association of Pharmaceutical Scientists (AAPS), Biomedical Engineering Society (BMES), New Zealand Institute of Chemistry (NZIC) and Materials Research Society (MRS), USA, Egyptian Society for Polymer Science & Technology (ESPST). He is also a Fellow of Royal Society of Chemistry.

Research Interest

His research interests include:
• Development and in-vitro assessment of new respirable/swellable nano-in-microparticles as potential carriers with adequate aerodynamic characteristics that can confer sustained drug release in the lung
• Synthesis of new amphiphilic polymers and development of novel self-assembled nanoparticles for intracellular gene delivery (Current focus: siRNA, miRNA delivery to the lung)
• Preparation of smart polymeric carriers (micro- & nanoparticles) for site-specific drug delivery, (Current focus: oral intestine-specific delivery of protein drugs and insulin)
• Enhancement of bioabsorption/bioavailability of water-insoluble drugs and natural therapeutics via polymeric nano-encapsulation
• Chemical modification of natural polymers and in-vitro evaluation of their bioactivity (Current focus: anticancer activity of some new chitosan derivatives)
• Smart hydrogel matrices as biodegradable scaffolds for tissue engineering & regenerative medicine
• Eco-friendly “Green” electrochemical synthesis, characterization, and in vitro evaluation of natural polymers-metals (Ag, Fe & Cu) hybrid nanoparticles and nanostructures for enhanced therapeutic activity
• Preparation of smart magnetically-responsive nanoparticles for D. delivery & biomedical applications

Scientific Activities

Honors and Awards:
• 4/2014 Best poster award: The 2014 Materials Research Society, MRS, Spring Meeting & Exhibition, San Francisco, California, USA, 21-25 April, 2014
• 3/ 2014 Honoring by Academy of Scientific Research and Technology (ASRT) & Minister of Scientific Research
• 9/2013 Venice Goda Award for Scientific Creativity for Young Researchers in the field of Materials Science and its Applications. (National Academy of Scientific Research, Egypt)
• 6/2012 Prestigious STATE Incentive Award in Science (National Academy of Scientific Research, Egypt)
• 11/2012 Appreciation Certificate & Medal from Mansoura University (Science Day 2012)
• 12/2011 Who’s Who in America (66th Edition, 2012)
• 7/2011 Who’s Who in the World (28th Edition, 2011)
• 7/2010 Rank of one of TOP 25 Hottest Articles (#24), For one of the published papers in (Int. J. of Pharmaceutics, USA, 2010)
• 2/2009 Fulbright Fellowship (School of Biomedical Engineering, Uni of Michigan, Ann Arbor, USA)
• 4/2007 Certificates of Best Posters, 3/2013 (Applied session, E), The 9th & 11th International Conference of Chemistry and its Role in Development, Sharm El-Sheikh, Egypt
• 6/2006 Travel Money, (Massey University) to visit research groups at University of Sharjah (UAE), University of Jordan (Amman, Jordan), Food Science Australia, FSA (Werribee) and University of Melbourne (Australia), Warwick University (England)
• 4/2006 IFS Graduate Research Fund (IFSGRF), Massey University to attend the Macro-group International Conference on Polymer Synthesis 2006, Warwick University, UK
• 1/2006 PhD. Scholarship, Massey University, Palmerstone North, New Zealand
(exemption from the tuition fees with backdating of the Ph.D. registration to 1/4/2004
• 8/2005, Rank of one of TOP 25 Hottest Articles (#9, # 11), 2011 (Science Direct) for TWO of the published papers (Eur. Polym. J., UK, & International Journal of Pharmaceutics, USA)
• 1/2004 PhD. Scholarship, (Channel System), from Egypt Government to study abroad
• 8/1997 An Honor Certificate, Egyptian Army- Air Defense Force
• 9/1994 Appreciation Certificate, El-Dakahlia Governorate, Egypt (Top Scholar, FSc., Mansoura University)
• 6/1994 Appreciation Certificate, Egyptian Syndicate of Scientific Professions

Professional Membership:
• American Association of Pharmaceutical Scientists (AAPS) (2008-present)
• Biomedical Engineering Society (BMES), USA (2009-present)
• New Zealand Institute of Chemistry, NZIC-membership (2006-2011)
• Materials Research Society (MRS), USA (2013-present)
• Science Age Society (SAS), (2012-present)
• American Royal Society (2010-present)
• Egyptian-American Scientists Association (EASA)- Medical Committee (2012-present)
• Egyptian Organization for Scientific Research and Technology (Co-founder), (2012-present)
• Egyptian Chemical Society (2011-pesent)
• Egyptian Society for Polymer Science & Technology (ESPST), (2007-present)
• Center for Separation Science, Massey University, New Zealand (2004-present)

Publications

Peer-Reviewed International Journals:
1. Elkholi IE, Hazem NM, ElKashef WF, et al. Evaluation of Anti-cancer Potential of Capsaicin-Loaded Trimethyl Chitosan-Based Nanoparticles in HepG2 Hepatocarcinoma Cells. Nanomedicine & Nanotechnology. 2014; 5(6): 240. doi: 10.4172/2157-7439.1000240
2. Guzman-Villanueva, D, El-Sherbiny IM, Vlassov AV, Herrera-Ruiz D, Smyth HDC. Enhanced cellular uptake and gene silencing activity of siRNA molecules mediated by chitosan-derivative nanocomplexes. Int J Pharmaceutics. 2014; 473(1-2): 579-590. doi: 10.1016/j.ijpharm.2014.07.026
3. Du, J, El-Sherbiny IM., Smyth HDC. Swellable Ciprofloxacin-loaded nano-in-micro hydrogel particles for local drug delivery. AAPS PharmSciTech. 2014; 15(6): 1535-1544. doi: 10.1208/s12249-014-0176-x
4. El-Sherbiny IM, Yahia S, Messiery MA, Reicha FM. Preparation and physicochemical characterization of new nanocomposites based on β-type chitosan and nano-hydroxyapatite as potential bone substitute materials. Int J Polymeric Materials and Polymeric Biomaterials. 2014; 63: 213-220. doi: 10.1080/00914037.2013.830249
5. El-Fallal AA, Degla H, El-Sherbiny IM. Assessment of a newly prepared silver nanoparticles suspension on the adhesion of biofilm on various denture base resin materials. Egy Dental J. 2014; 60 (2): 1-11.
6. El-Negoly SA, El-Fallal AA, El-Sherbiny IM. A new modification for improving shear bond strength and other mechanical properties of conventional glass-ionomer restorative materials. J Adhesive Dentistry. 2014; 16(1):41-47. doi: 10.3290/j.jad.a30541
7. El Shahaby O, El Zayat M, Salih E, El-Sherbiny IM, Reicha FM. Evaluation of antimicrobial activity of water infusion plant-mediated silver nanoparticles. Nanomedicine & Nanotechnology. 2013; 4(4): 178. doi: 10.4172/2157-7439.1000178
8. El-Sherbiny IM, Abdel-Hamid MI, Rashad M, Ali ASM, Azab YA. New calcareous soil-alginate composites for efficient uptake of Fe(III): Mn(II) and As(V) from water. Carbohydrate Polymers. 2013; 96: 450-459. doi: 10.1016/j.carbpol.2013.04.021
9. Guzman-Villanueva D, El-Sherbiny IM, Herrera-Ruiz D, Smyth HDC. Design and in vitro evaluation of new nano-microparticulate system for enhanced aqueous-phase dissolution and bioavailability of curcumin. Biomedical Research International. 2013; 2013: 1-10. doi: http://dx.doi.org/10.1155/2013/724763
10. El-Sherbiny IM, Salih E, Reicha FM. Green synthesis of densely dispersed and stable silver nanoparticles using myrrh extract and evaluation of their antibacterial activity. J Nanostructure in Chemistry. 2013; 3: 8. doi: 10.1186/2193-8865-3-8
11. Abdel-Razik EA, Shehata AE, El-Sherbiny IM. Photoinduced grafting of methyl methacrylate onto dehydrochlorinated poly (vinyl chloride) using a combination of dimethylaniline and benzoyl peroxide as initiator system. Int J Research in Engineering and Science (IJRES). 2013; 1(8): 1-11.
12. El-Sherbiny IM, Smyth HDC. Controlled release pulmonary administration of curcumin using swellable biocompatible nano-microparticles systems. Molecular Pharmaceutics. 2012; 9(2): 269-280. doi: 10.1021/mp200351y
13. Reicha FM, Sarhan A, Abdel Hamid MI, El-Sherbiny IM. Preparation of silver nanoparticles in the presence of chitosan by electrochemical method. Carbohydrate Polymers. 2012; 89(1): 236-244.doi: 10.1016/j.carbpol.2012.03.002
14. El-Far M, Refaat M, El-Sherbiny IM. A comparative study between the anticancer activities of chitosan and carboxymethyl chitosan. Current Topics in Biochemical Research. 2012; 14(1): 35-43.
15. Dawidar AM, Abdel-Mogib M, El-Sherbiny IM, Saeed AA. Terpenes, steroids and shikiimates in Calligonum Comosum L. Man Journal of Biology. 2012; 211-224.
16. El-Sherbiny IM, Abdel-Hamid MI, Rashad M, Ali ASM, Azab YA. Preparation and Assessment of Enhanced Alginate-Based Composites as Potential Sorbents for Water Treatment. Journal of Environmental Sciences. 2012; 407-421.
17. El-Sherbiny IM, Smyth HDC. Smart magnetically-responsive hydrogel nanoparticles prepared by a novel aerosol-assisted method for biomedical and drug delivery applications. Journal of Nanomaterials. 2011; 2011: 1-13. doi: 10.1155/2011/910539
18. El-Sherbiny IM, Abdel-Mogib M, Dawidar A, Elsayed A, Hugh DC. Smyth HDC. Biodegradable pH-responsive alginate-poly (lactic-co-glycolic acid) nano/micro hydrogel matrices for oral delivery of silymarin. Carbohydrate Polymers. 2011; 83: 1345-1354.
19. El-Far M, El-Shal M, Refaat M, El-Sherbiny IM. Anti-tumor activity and antioxidant role of a novel water soluble carboxymethyl chitosan-based copolymer. Drug Development and Industrial Pharmacy. 2011; 37(12): 1481-1490. doi: 10.3109/03639045.2011.587430
20. Guzman-Villanueva D, Smyth HDC, Herrera-Ruiz D, El-Sherbiny IM. A Novel aerosol method for the production of hydrogel particles. Journal of Nanomaterials. 2011; 2011: 1-10. doi: 10.1155/2011/507508
21. El-Sherbiny IM, Smyth HDC. Biodegradable nano-micro carrier systems for sustained pulmonary drug delivery: (I) Self-assembled nanoparticles encapsulated in respirable/swellable semi-IPN microspheres. International Journal of Pharmaceutics. 2010; 395: 132-141. doi: 10.1016/j.ijpharm.2010.05.032
22. El-Sherbiny IM, Mcgill S, Smyth HDC. Swellable microparticles as carriers for sustained pulmonary drug delivery. Journal of Pharmaceutical Sciences. 2010; 99(5): 2343-2356. doi: 10.1002/jps.22003
23. El-Sherbiny IM, Smyth HDC. Novel cryomilled physically crosslinked biodegradable hydrogel microparticles as carriers for inhalation therapy. Journal of Microencapsulation: Micro and Nano carriers. 2010; 27(7): 561-572. doi: 10.3109/02652041003739840
24. El-Sherbiny IM, Smyth HDC. Photo-induced synthesis, characterization and swelling behavior of poly(2-Hydroxyethyl methacrylate) grafted carboxymethyl chitosan. Carbohydrate Polymers. 2010; 81: 652-659. doi: 10.1016/j.carbpol.2010.03.027
25. El-Sherbiny IM. Enhanced pH-responsive carrier system based on alginate and chemically modified carboxymethyl chitosan for oral delivery of protein drugs: preparation and in-vitro assessment. Carbohydrate Polymers. 2010; 80(4): 1125-1136. doi: 10.1016/j.carbpol.2010.01.034
26. El-Sherbiny IM, Abdel-Bary EM, Harding DRK. Preparation and in-vitro evaluation of new pH-sensitive hydrogel beads for oral delivery of protein drugs. Journal of Applied Polymer Science. 2010; 115: 2828-2837. doi: 10.1002/app.30881
27. El-Sherbiny IM, Elmahdy ME. Preparation, characterization, structure, and dynamics of carboxymethyl chitosan grafted with acrylic acid sodium salt. Journal of Applied Polymer Science. 2010; 118: 2134-2145. doi: 10.1002/app.32517
28. El-Sherbiny IM, Smyth HDC. Poly(ethylene glycol)/carboxymethyl chitosan-based pH-responsive hydrogels: Photo-induced synthesis, characterization, swelling and in-vitro evaluation as potential drug carriers. Carbohydrate Research. 2010; 345(14): 2004-2012. doi: 10.1016/j.carres.2010.07.026
29. Selvam P, El-Sherbiny IM, Smyth HDC. Swellable hydrogel particles for controlled release pulmonary administration of curcumin using propellant driven metered dose inhalers. Journal of Aerosol Medicine and Pulmonary Drug Delivery. 2010; 23: 1-10. doi: 10.1089/jamp.2010.0830
30. Mobarak HM, El-Sherbiny IM, Abdel-Mogib M. Triterpenoids and volatile components of Euphorbia Tirucalli. Mans Journal of Chemistry. 2010; 37(2): 43-52.
31. El-Sherbiny IM, Salama A, Sarhan AA. Ionotropically-crosslinked pH-sensitive IPN hydrogel matrices as potential carriers for intestine-specific oral delivery of protein drugs. Drug Development and Industrial Pharmacy. 2010; 37(2): 121-130. doi: 10.3109/03639045.2010.495754
32. El-Sherbiny IM. Synthesis, characterization and metal uptake capacity of a new carboxymethyl chitosan derivative. European Polymer Journal. 2009; 45: 199-210. doi: 10.1016/j.eurpolymj.2008.10.042
33. El-Sherbiny IM, Salama A, Sarhan AA. Grafting study and antifungal activity of a carboxymethyl cellulose derivative. International Journal of Polymeric Materials. 2009; 58: 453-467. doi: 10.1080/00914030902936519
34. Abdel Bary EM, Abdelaal MY, Kenawy IM, El-Sherbiny IM, Moawad E, Hussein NH. Purification of wastewater from heavy metal ions using modified polymers. Mans Journal of Chemistry. 2009; 36(1): 115-138.
35. Abdelaal MY, Abdel-Razik EA, Abdel-Bary EM, El-Sherbiny IM. Study on chitosan-poly(vinyl alcohol) interpolymeric pH-responsive hydrogel films for controlled drug delivery. Journal of Applied Polymer Science. 2007; 103: 2864-2874.
36. El-Sherbiny IM, Abdel-Bary EM, Harding DRK. Preparation and swelling study of a pH-dependent interpolymeric hydrogel based on chitosan for controlled drug release. International Journal of Polymeric Materials. 2006; 55: 789-802. doi: 10.1080/00914030500440245
37. El-Sherbiny IM, Abdel-Bary EM, Harding DRK. Swelling characteristics and in-vitro drug release study with pH and thermo-sensitive hydrogels based on modified chitosan. Journal of Applied Polymer Science. 2006; 102: 977-985.
38. El-Sherbiny IM, Lins RJ, Abdel-Bary EM, Harding DRK. Preparation, characterization, swelling and in-vitro drug release behavior of poly [N-acryloylglycine-chitosan] interpolymeric pH and thermally-responsive hydrogels. European Polymer Journal. 2005; 41: 2584-2591. doi: 10.1016/j.eurpolymj.2005.05.035
39. Abdel-Bary EM, Abdel-Razik EA, Abdelaal MY, El-Sherbiny IM. Stability of polypropylene blends under the effect of thermal and UV-degradation. Polymer-Plastics Technology & Engineering, (USA). 2005; 44(5): 847-862. doi: 10.1081/PTE-200060842