Guanglin Bian, PhD

Department of Immunology
Cleveland Clinic Lerner Research Institute
9500 Euclid Avenue
Cleveland, Ohio 44195, USA



• (9/2006-7/2009) PhD, Lab of Medical Molecular Virology, Fudan University, China
• (9/2003-7/2006) Master of Science, Department of Immunology, Zhengzhou University, China
• (9/1997-7/2000) Medical Student, Hebei Engineering University, China


• (6/2015-Present) Postdoc, Cleveland Clinic Lerner Research Institute
• (1/2013-6/2015) Postdoc, Mount Sinai school of Medicine
• (6/2010-1/2013) Postdoc, Roswell Park Cancer Institute, Buffalo, NY, USA
• (6/2009-5/2010) Assistant researcher, Shanghai Jiao Tong University, China
• (9/2006-7/2009) Graduate study in Fudan University, China

Research Interest

His research interests include: Vaccination research.

Scientific Activities


1. Bian G, Ding X, Leigh ND, et al. Granzyme B-Mediated Damage of CD8+ T Cells Impairs Graft-versus-Tumor Effect. The Journal of Immunology. 2013; 190(3): 1341-1350. doi: 10.4049/jimmunol.1201554
2. Ding X, Bian G, Leigh ND, et al. A TLR5 ligand-C502 enhances CD8+ T cell-mediated graft-versus- leukemia effect without exacerbating graft-versus-host disease. The Journal of Immunology. 2012; 189(10): 4719-4727.
3. Bian G, Cheng Y, Wang Z, et al. Whole recombinant Hansenula polymorpha expressing hepatitis B virus surface antigen (yeast- HBsAg) induces potent HBsAg-specific Th1 and Th2 immune responses. Vaccine. 2010; 28(1): 187-194. doi: 10.1016/j.vaccine.2009.09.101
4. Leigh ND, Bian G, Ding X, et al. A Flagellin-Derived Toll-Like Receptor 5 Agonist Stimulates Cytotoxic Lymphocyte-Mediated Tumor Immunity. PloS one. 2014; 9(1): e85587. doi: 10.1371/journal.pone.0085587
5. Du W, Leigh ND, Bian G, et al. Granzyme B-Mediated Activation-Induced Death of CD4+ T Cells Inhibits Murine Acute Graft-versus-Host Disease. The Journal of Immunology. 2015; 195(9): 4514-4523. doi: 10.4049/jimmunol.1500668
6. Bian G. Identification of Bacteroides fragilis by 16S rRNA PCR. Letters in Biotechnology. 2006; 17(1): 66-67.
7. Luo Yu, Bian G. Detection bacteria fragile by SYBR Green real-time PCR. Chin J Public Health. 2007; 23(1): 100-101.