Ghassan M. Saed, PhD

Associate Professor
Department of Obstetrics and Gynecology
Wayne State University School of Medicine
540 E Canfield St
Detroit, MI 48201, USA

 

Biography

Dr. Saed is currently an Associate Professor in the Department of Obstetrics and Gynecology at Wayne State University School of Medicine in Detroit, Michigan. He is an internationally renowned clinical and translational investigator, who is recognized for many scientific contributions within the fields of Reproductive Endocrinology and Infertility and Gynecologic Oncology.
Dr. Saed has over 20 years of experience in the pathogenesis of tissue fibrosis and cancer. He is extensively published in this area, particularly in the implications of extracellular matrix molecules, growth factors, free radicals, apoptosis and proliferation in tissue scarring and cancer.

Research Interest

His research interests includes: Molecular mechanisms investigating the role of oxidative stress in the pathogenesis of ovarian cancer and the Development of Chemoresistance. Comparison of the effects of oxidative stress on the pathogenesis of a Malignant overgrowth versus a benign overgrowth, such as postoperative adhesions are also a major focus of his research.

Scientific Activities

MAJOR PROFESSIONAL SOCIETIES

• American Association of Cancer Research
• American Association of University Professors
• American Chemical Society
• American Federation of Clinical Research
• American Society for Reproductive Medicine
• National Arab American Medical Association
• Society for Gynecologic Investigation

HONORS/AWARDS

• (1984-1998) Medical Research Council of the United Kingdom
• (1985-1986) National Research Council of the United Kingdom
• (1996-1997) Outstanding Professor of the Year Award nominee by the Golden Key National Society, Oakland University Chapter, Rochester, MI
• (1998) Award Paper, Society of Reproductive Surgeons
• (2000) Finalist Paper, Society of Reproductive Endocrinologists
• (2000) Award Paper, Society of Reproductive Surgeons
• (2003) Finalist Paper, European Society of Human Reproduction
• (2003) Finalist Paper, Society of Reproductive Endocrinologists
• (2005) Finalist Paper, American Society for Reproductive Medicine
• (2006) Finalist Paper, American Society for Reproductive Medicine
• (2009) Nominated for President’s Award for Excellence in Teaching, Wayne State University School of Medicine, Detroit, MI
• (2011) American Society for Reproductive Medicine (ASRM) Star Award (awarded to reproductive health professionals who have presented at at least nine of the last ten ASRM annual meetings)
• (2013) American Society for Reproductive Medicine (ASRM) Star Award (awarded to reproductive health professionals who have presented at at least nine of the last ten ASRM annual meetings)

Publications

Refereed Journals

1. El-Thaher TS, Saed GM, Bailey GS. A simple and rapid purification of kallikrein from rat submandibular gland. Biochemical and Biophsical Acta. 1990; 1034(2): 157-161.
2. Saed GM, Carretero OA, MacDonald R, Scicli AG. Kallikrein messenger RNA in rat arteries and veins. Circulation Research. 1990; 67(2): 510-516.
3. Saed GM, Beierwaltes WH, Carretero OA, Scicli AG. Submandibular enzymatic vasoconstrictor messenger RNA in rat kidney. Hypertension. 1992; 19(2): 11262-11267.
4. el-Thaher TS, Saed GM, Bailey GS. Characterization of kallikrein isolated from rat submandibular glands by a simple and rapid purification procedure. Agents and Action Supplement . 1992; 38(1): 98-105.
5. Nolly H, Saed GM, Scicli AG, Carretero OA, Scicli AG. The Kallikrein-Kinin system in cardiac tissue. Agents and Actions Supplement. 1992; 38(3): 62-72.
6. Nolly H, Saed G, Carretero O, Scicli AG. Adrenal kallikrein. Hypertension. 1993; 21 (6): 911-915.
7. Valdés G, Corthorn J, Scicli AG, et al. Uterine kallikrein in the early pregnant rat. Biology of Reproduction. 1993; 49(4): 802-808.
8. Joseph R, Tsang W, Han E, Saed GM. Neuoronal beta-amyloid precursor protein gene expression: Regulation by aurintricarboxylic acid. Brain Research. 1993; 625(2): 244-255.
9. Fivenson DR, Saed GM, Beck ER, Dunstan RW, Moore PF. T-cell receptor gene rearrangement in canine mycosis fungoides: Further support for a canine model of cutaneous T-cell lymphoma. Journal of Investigative Dermatology. 1994; 102(2): 227-230.
10. Saed GM, Fivenson DP, Nickoloff BJ. Mycosis fungoides exhibits a Th1 type cell-mediated cytokine profile whereas Sezary syndrome expresses a Th2 type profile. Journal of Investigative Dermatology. 1994; 103(1): 29-33. doi: 10.1111/1523-1747.ep12388985
11. Saed GM, Fivenson DP. Quantitation of interferon-gamma mRNA levels in psoralen/UVA-treated HUT-78 cells by competitive PCR. Biochemical and Biophysical Research Communication. , 1994; 203(2): 935-942. 10.1006/bbrc.1994.2272
12. Dillon WI, Saed GM, Fivenson DP. Borrellia burgdorferi DNA is undetectable by polymerase chain reaction in skin lesions of morphea, scleroderma and lichen sclerosus et atrophicus of patients from North America. Journal of the American Academy of Dermatology. 1995; 33(4): 617-620.
13. Fivenson DP, Schaffer J, Saed GM, Beck ER, Wood GS. Absence of human T-cell lymphotropic virus genomic determinants in canine mycosis fungoides. Archives of Dermatology. 1996; 132(1): 841-842,
14. Stein L, Saed GM, Fivenson DP. T-cell cytokine network in cutaneous lupus erythematosus. Journal of the American Academy of Dermatology. 1997; 36 (2(1)):191-196.
15. Ricketts CH, Martin L, Faria DT, Saed GM, Fivenson DP. Cytokine mRNA changes during the treatment of hypertrophic scars with silicone and non-silicone gel dressings. Dermatology Surgery. 1996; a. 22(11): 955-964.
16. Ladin DA, Hou Z, Patel D, et al. p53 and apoptosis alterations in keloids and keloid fibroblasts. Wound Repair and Regeneration. 1998; 6(1): 28-37.
17. Saed G, Ladin D, Olsen J, Han X, Hou Z, Fivenson D. Analysis of p53 gene mutations in keloids using polymerase chain reaction-based single-strand conformational polymorphism and DNA sequencing. Archives of Dermatology . 1998; 134(8): 963-967.
18. Saed GM, Zhang W, Chegini N, Holmdhal L, Diamond MP. Alteration of type I and III collagen expression in human peritoneal mesothelial cells in response to hypoxia and transforming growth factor-beta1. Wound Repair and Regeneration. 1999; 7(6): 504-510.
19. Wittenberg GP, Fabian BG, Bogomilsky JL, et al. Prospective, single-blind, randomized, controlled study to assess the efficacy of the 585-nm flashlamp-pumped pulsed-dye laser and silicone gel sheeting in hypertrophic scar treatment. Archives of Dermatology. 1999; 135(9): 1049-1055. doi: 10.1001/archderm.135.9.1049
20. Saed GM, Zhang W, Chegini N, Holmdahl L, Diamond MP. Transforming growth factor beta isoforms production by human peritoneal mesothelial cells after exposure to hypoxia. American Journal of Reproductive Immunology. 2000; 43(5): 285-291.
21. Saed GM, Zhang W, Diamond MP. Effect of hypoxia on the stimulatory effect of TGF-beta 1 on MMP-2 amd MMP-9 activities in mouse fibroblasts. Journal of the Society of Gynecologic Investigation. 2000; 7(6): 348-354.
22. Saed GM, Zhang W, Diamond MP. Molecular characterization of fibroblasts isolated from human peritoneum and adhesions. Fertility and Sterility. 2001; 75(4): 763-768. doi: 10.1177/107155760000700606
23. Chegini N, Kotseos K, Ma C, et al. Peritoneal Healing and Adhesion Multi-University Study Group. Differential expression of integrin alphav and beta3 in serosal tissues of human intraperitoneal organs and adhesion. Fertility and Sterility. 2001; 75(4): 791-796.
24. Chegini N, Kotseos K, Bennett B, et al. Peritoneal Healing and Adhesion Multi-University Study Group. Matrix metalloproteinase (MMP-1) and tissue inhibitor of MMP in peritoneal fluids and sera and correlation with peritoneal adhesions. Fertility and Sterility. , 2001; 76(6): 1207-1211.
25. Chegini N, Kotseos K, Zhao Y, et al. Peritoneal Healing and Adhesion Multi-University Study (PHAMUS) Group. Expression of matrix metalloproteinase (MMP-1) and tissue inhibitor of MMP in serosal tissue of intraperitoneal organs and adhesions. Fertility and Sterility. 2001; 76(6): 1212-1219.
26. Svinarich DM, Zaher FM, Holmdahl L, et al. Peritoneal Healing and Adhesion Multi-University Study (PHAMUS) Group. Adhesion development and the expression of endothelial nitric oxide synthase. Infectious Diseases in Obstetrics and Gynecology. , 2001; 9(2): 113-116.
27. Chegini N, Kotseos K, Zhao Y, et al. Peritoneal Healing and Adhesion Multi-University Study (PHAMUS) Group. Differential expression of TGF-beta1 and TGF-beta3 in serosal tissues of human intraperitoneal organs and peritoneal adhesions. Journal of Molecular Human Reproduction. 16(6):1291-1300, 2001.
28. Saed GM, Diamond MP. Apoptosis and proliferation of human peritoneal fibroblasts in response to hypoxia. Fertility and Sterility. 78(1): 137-143.
29. Saed GM, Diamond MP. Hypoxia-induced irreversible up-regulation of type I collagen and transforming growth factor-beta1 in human peritoneal fibroblasts. Fertility and Sterility. 2002; 78(1):144-147.
30. Saed GM, Collins KL, Diamond MP. Transforming growth factors beta1, beta2, and beta3 and their receptors are differentially expressed in human peritoneal fibroblasts in response to hypoxia. American Journal of Reproductive Immunology. 2002; 48(6):387-393.
31. Rout UK, Saed GM, Diamond MP. Transforming growth factor-beta1 modulates expression of adhesion and cytoskeletal proteins in human peritoneal fibroblasts. Fertility and Sterility. 2002; 78(1):154-161. doi: 10.1016/S0015-0282(02)03176-X
32. Munkarah AR, Morris RT, Baumann P, et al. Effects of prostaglandin E(2) on proliferation and apoptosis of epithelial ovarian cancer cells. Journal of the Society for Gynecologic Investigation. , 2002; 9(3):168-173.
33. Diamond MP, Elhammady E, Wang R, Saed G. Metabolic regulation of collagen I in fibroblasts isolated from normal peritoneum and adhesions by dichloroacetic acid. American Journal of Obstetrics and Gynecology. 2002; 187(6):1456-1460;
34. Freeman ML, Saed GM, Diamond MP. Hormone-independent ovarian influence on adhesion development. Fertility and Sterility. 2002; 78(2): 340-346, 2002.
35. Chegini N, Zhao Y, Kotseos K, et al. Peritoneal Healing and Adhesion Multi-University Study Group. Differential expression of matrix metalloproteinase and tissue inhibitor of MMP in tissue of serosal intraperitoneal organs and adhesions. British Journal of Obstetrics and Gynecology . 2002; 109(9): 1041-1049.
36. Munkarah AR, Genhai Z, Morris R, et al. Inhibition of paclitaxel-induced apoptosis by the specific COX-2 inhibitor, NS398, in epithelial ovarian cancer cells. Gynecologic Oncology. 2003; 88(3): 429-433.
37. Saed GM, Diamond MP. Effect of glucose on the expression of type I collagen and transforming growth factor-beta1 in cultured human peritoneal fibroblasts. Fertility and Sterility. 2003; 79(1): 158-163.
38. Saed GM, Diamond MP. Modulation of the expression of tissue plasminogen activator and its inhibitor by hypoxia in human peritoneal and adhesion fibroblasts. Fertility and Sterility. 2003; 79(1): 164-168.
39. Diamond MP, Elhammady E, Wang R, Saed GM. Regulation of transforming growth factor-beta, type III collagen, and fibronectin by dichloroacetic acid in human fibroblasts from normal peritoneum and adhesions. Fertility and Sterility. 2003; 79(5): 1161-1167.
40. Saed GM, Munkarah AR, Diamond MP. Cyclooxygenase-2 is expressed in human fibroblasts isolated from intraperitoneal adhesions but not from normal peritoneal tissues. Fertility and Sterility. 2003; 79(6): 1404-1408,.
41. Freeman ML, Saed GM, Elhammady EF, Diamond MP. Expression of transforming growth factor beta isoform mRNA in injured peritoneum that healed with adhesions and without adhesions and in uninjured peritoneum. Fertility and Sterility. 2003; 80(2): 708-713.
42. Gago LA, Saed GM, Chauhan S, Elhammady EF, Diamond MP. Seprafilm (modified hyaluronic acid and carboxymethylcellulose) acts as a physical barrier. Fertility and Sterility. 2003; 80(3): 612-616.
43. Gago LA, Saed GM, Wang RX, Kruger M, Diamond MP. Effects of oxidized regenerated cellulose on the expression of extracellular matrix and transforming growth factor-beta1 in human peritoneal fibroblasts and mesothelial cells. American Journal of Obstetrics and Gynecology. 189(6): 1620-1625.
44. Galijasevic S, Saed GM, Diamond MP, Abu-Soud HM. Myeloperoxidase up-regulates the catalytic activity of inducible nitric oxide synthase by preventing the nitric oxide feedback inhibition. Proceedings of the National Academy of Sciences. 2003; 100(25): 14766-14771.
45. Saed GM, Diamond MP. Effect of glucose on the expression of type I collagen and transforming growth factor-beta1 in cultured human peritoneal fibroblasts. Fertility and Sterility . 2003; 79(1):158-163.
46. Diamond MP, Elhammady E, Wang R, Saed G. Regulation of matrix metalloproteinase-1 and tissue inhibitor of matrix metalloproteinase-1 by dichloroacetic acid in human fibroblasts from normal peritoneum and adhesions. Fertility and Sterility. 2004; 81(1): 185-190.
47. Diamond MP, Kruger M, Saed GM. Effect of Tisseel on expression of tissue plasminogen activator and plasminogen activator inhibitor-1. Fertility and Sterility. 2004; 81(6):1657-1664.
48. Zhu G, Saed GM, Deppe G, Diamond MP, Munkarah AR. Hypoxia up-regulates the effects of prostaglandin E2 on tumor angiogenesis in ovarian cancer cells. Gynecologic Oncology . 2004; 94(2): 422-426. 10.1016/j.ygyno.2004.05.010
49. Galijasevic S, Saed GM, Diamond MP, Abu-Soud HM. High dissociation rate constant of ferrous-dioxy complex linked to the catalase-like activity in lactoperoxidase. Journal of Biological Chemistry. 2004; 279(38): 39465-39470.
50. Diamond MP, El-Hammady E, Wang R, Kruger M, Saed G. Regulation of expression of tissue plasminogen activator and plasminogen activator inhibitor-1 by dichloroacetic acid in human fibroblasts from normal peritoneum and adhesions. American Journal of Obstetrics and Gynecology . 2004; 190(4): 926-934.
51. Saed GM, Diamond MP. Molecular characterization of postoperative adhesions: the adhesion phenotype. Journal of the American Association for Gynecologic Laparoscopists. 2004; 11(3):307-314.
52. Saed GM, Kruger M, Diamond MP. Expression of transforming growth factor beta and extracellular matrix by human peritoneal mesothelial cells and by fibroblasts from normal peritoneum and adhesions: effect of Tisseel. Wound Repair and Regeneration. 2004; 12(5):557-564.
53. Buhimschi IA, Jabr M, Buhimschi CS, Petkova AP, Weiner CP, Saed GM. The novel antimicrobial peptide beta3-defensin is produced by the amnion: a possible role of the fetal membranes in innate immunity of the amniotic cavity. American Journal of Obstetrics and Gynecology. 2004; 191(5):1678-1687.
54. Saed GM, Abu-Soud HM, Diamond MP. Role of nitric oxide in apoptosis of human peritoneal and adhesion fibroblasts after hypoxia. Fertility and Sterility . 2004; 82 Suppl 3: 1198-1205, 2004.
55. Saed GM, Diamond MP. Differential expression of alpha smooth muscle cell actin in human fibroblasts isolated from intraperitoneal adhesions and normal peritoneal tissues. Fertility and Sterility. 2004; 82 Suppl 3: 1188-1192, 2004.
56. Saed GM, Galijasevic S, Diamond MP, Abu-Soud HM. Measurement of oxygen and nitric oxide levels in vitro and in vivo: relationship to postoperative adhesions. Fertility and Sterility. 2005; 84(1): 235-238, 2005.
57. Saed GM, Munkarah AR, Abu-Soud HM, Diamond MP. Hypoxia upregulates cyclooxygenase- 2 and prostaglandin E(2) levels in human peritoneal fibroblasts. Fertility and Sterility. 2005; 83 Suppl 1: 1216-1219, 2005.
58. Diamond MP, Elhammady E, Munkarah A, Bieber EJ, Saed GM. Modulation of the expression of vascular endothelial growth factor in human fibroblasts. Fertility and Sterility . 2005; 83(2): 405-409, 2005.
59. Rout UK, Saed GM, Diamond MP. Expression pattern and regulation of genes differ between fibroblasts of adhesion and normal human peritoneum. Reproductive Biology and Endocrinology. 3: 1.
60. Saed GM, Kruger ML, Diamond MP. Enhanced matrix metalloproteinase expression by Tisseel in mesothelial cells, normal peritoneal fibroblasts, and adhesion fibroblasts. European Journal of Plastic Surgery. 28(7):472-479, 2006.
61. Gago, LA, Saed G, Elhammady E, Diamond MP. Effect of oxidized regenerated cellulose (Interceed) on the expression of tissue plasminogen activator and plasminogen activator inhibitor-1 in human peritoneal fibroblasts and mesothelial cells. Fertility and Sterility. 86(4 Suppl):1223-1227, 2006.
62. insulin and insulin-like growth factor-I receptors in human normal peritoneal and adhesion fibroblasts. Fertility and Sterility. 2006; 86(4 Suppl):1217-1222.
63. Alpay Z, Saed GM, Diamond MP. Female infertility and free radicals: Potential role in adhesions and endometriosis. Journal for the Society for Gynecologic Investigation. 2006; 13(6): 390-398.
64. Malone JM, Saed GM, Diamond MP, Sokol RJ, Munkarah AR. The effects of the inhibition of inducible nitric oxide synthase on angiogenesis of epithelial ovarian cancer. American Journal of Obstetrics and Gynecology. 2006; 194(4): 1110-1116.
65. Alpay Z, Ozgönenel MS, Savasan S, Buck S, Saed GM, Diamond MP. Possible role of natural immune response against altered fibroblasts in the development of post-operative adhesions. American Journal of Reproductive Immunology . 2006; 55(6):420-427.
66. Saed GM, Diamond MP. Effects of interferon-gamma reverse hypoxia-stimulated extracellular matrix expression in human peritoneal and adhesion fibroblasts. Fertility and Sterility. 2006; 85 Suppl 1: 1300-1305.
67. Saed GM, Zhao M, Diamond MP, Abu-Soud HM. Regulation of inducible nitric oxide synthase in post-operative adhesions. Human Reproduction. 2006; 21(6):1605-1611.
68. Galijasevic S, Saed GM, Hazen SL, Abu-Soud HM. Myeloperoxidase metabolizes thiocyanate in a reaction driven by nitric oxide. Biochemistry. 2006; 45(4): 1255-1262. doi: 10.1021/bi051438k
69. Munkarah AR, Ali-Fehmi R, Jiang JZ, Elhammady E, Malone JM Jr, Saed GM. The effects of combining docetaxel and cyclooxygenase-2 inhibitors on proliferation and apoptosis in epithelial ovarian cancer. Anticancer Drugs. 2007; 18(8): 889-896.
70. Victory R, Saed GM, Diamond MP. Antiadhesion effects of docosahexaenoic acid on normal human peritoneal and adhesion fibroblasts. Fertility and Sterility. 2007; 88(6): 1657-1662.
71. Diamond MP, Saed G. Modulation of the expression of peroxisome proliferators-activated receptors in human fibroblasts. Fertility and Sterility. 2007; 87(3): 706-709.
72. Alpay Z, Ozgönenel M, Savasan S, Buck S, Saed GM, Diamond MP. Altered in vitro immune response to hypoxia-treated normal peritoneal fibroblasts. Fertility and Sterility. 2007; 87(2): 426-429. doi: 10.1016/j.fertnstert.2006.07.1495
73. Pansare V, Munkarah AR, Schimp V, et al. Increased expression of hypoxia-inducible factor 1-alpha in type I and type II endometrial carcinomas. Modern Pathology. 2007; 20(1): 35-43.
74. Saed GM. Immunohistochemical staining of cyclooxygenases with monoclonal antibodies. Methods in Molecular Biology. 2008; 477: 219-228.
75. Saed GM, Al-Hendy A, Salama SA, Diamond MP. Adenovirus-mediated expression of cyclooxygenase-2 antisense reverses abnormal genetic profile of human adhesion fibroblasts. Fertility and Sterility. 2008; 89(5 Suppl): 1455-1460
76. Diamond MP, Wirth JJ, Saed GM. PCBs enhance collagen I expression from human peritoneal fibroblasts. Fertility and Sterility. 2008; 90(4): 1372-1375. doi: 10.1016/j.fertnstert.2007.07.1380
77. Alpay Z, Saed GM, Diamond MP. Postoperative adhesions: from formation to prevention. Seminars in Reproductive Medicine. 2008; 26(4): 313-321. doi: 10.1055/s-0028-1082389
78. Imudia AN, Kumar S, Saed GM, Diamond MP. Pathogenesis of intra-abdominal and pelvic adhesion development. Seminars in Reproductive Medicine. 2008; 26(4): 289-297.
79. Detti L, Saed GM, Jiang ZL, Kruger ML, Diamond MP. The effect of estradiol on the expression of estrogen, progesterone, androgen, and prolactin receptors in human peritoneal fibroblasts. Journal of Assisted Reproduction and Genetics. 2008; 25(6): 245-250. doi: 10.1007/s10815-008-9230-5
80. Fletcher NM, Jiang ZL, Diamond MP, Abu-Soud HM, Saed GM. Hypoxia-generated superoxide induces the development of the adhesion phenotype. Free Radical Biology and Medicine. 2008; 45(4): 530-536. doi: 10.1016/j.freeradbiomed.2008.05.002
81. Jiang ZL, Zhu X, Diamond MP, Abu-Soud HM, Saed GM. Nitric oxide synthase isoforms expression in fibroblasts isolated from human normal peritoneum and adhesion tissues. Fertility and Sterility. 2008; 90(3): 769-764.
82. Saed GM, Jiang Z, Fletcher NM, Diamond MP. Modulation of the BCL-2/BAX ratio by interferon-gamma and hypoxia in human peritoneal and adhesion fibroblasts. Fertility and Sterility . 2008; 90(5): 1925-1930.
83. Saed GM, Jiang Z, Diamond MP, Abu-Soud HM. The role of myeloperoxidase in the pathogenesis of postoperative adhesions. Wound Repair and Regeneration. 2009; 17(4): 531-539 .
84. Shavell VI, Saed GM, Diamond MP. Review: Cellular metabolism: contribution to postoperative adhesion development. Reproductive Sciences. 2009; 16(7): 627-634. doi: 10.1177/1933719109332826
85. Jiang ZL, Fletcher NM, Diamond MP, Abu-Soud HM, Saed GM. Hypoxia regulates iNOS expression in human normal peritoneal and adhesion fibroblasts through nuclear factor kappa B activation mechanism. Fertility and Sterility. 2009; 91(2): 616-621.
86. Jiang ZL, Fletcher NM, Diamond MP, Abu-Soud HM, Saed GM. S-nitrosylation of caspase-3 in the mechanism by which adhesion fibroblasts manifest lower apoptosis. Wound Repair and Regeneration. 2009; 17(2): 224-229. doi: 10.1111/j.1524-475X.2009.00459.x
87. Awongua A, Diamond M, Saed G. Laparoscopy in gynecologic surgery: adhesion development, prevention and use of adjunctive therapies. Clinical Obstetrics and Gynecology . 2009; 52(3): 412-422. doi: 10.1097/GRF.0b013e3181b0c121
88. Saed GM, Ali-Fehmi R, Jiang ZL, et al. Myeloperoxidase serves as a redox switch that regulates apoptosis in epithelial ovarian cancer. Gynecologic Oncology. 2010; 116(2): 276-281.
89. Saed GM, Jiang ZL, Fletcher NM, Al Arab A, Diamond MP, Abu-Soud HM. Exposure to polychlorinated biphenyls enchances lipid peroxidation in human normal peritoneal and adhesion fibroblasts: a potential role for myeloperoxidase. Free Radical Biology and Medicine. 2010; 48(6): 845-850.
90. Pennathur S, Maitra D, Byun J, et al. Potent antioxidative activity of lycopene: A potential role in scavenging hypochlorous acid. Free Radical Biology and Medicine. 2010; 49(2): 205-213. doi: 10.1016/j.freeradbiomed.2010.04.003
91. Bryant CS, Munkarah AR, Kumar S, et al. Reduction of hypoxia-induced angiogenesis in ovarian cancer cells by inhibition of HIF-1 alpha gene expression. Archives of Gynecology and Obstetrics. 2010; 282(6): 677-683.
92. Ali-Fehmi R, Semaan A, Sethi S, et al. Molecular typing of epithelial ovarian carcinomas using inflammatory markers. Cancer. 2011; 117(2): 301-309. doi: 10.1002/cncr.25588
93. Fletcher NM, Jiang Z, Ali-Fehmi R, et al. Myeloperoxidase and free iron levels: potential biomarkers for early detection and prognosis of ovarian cancer. Cancer Biomarkers. 2011; 10(6): 267-275.
94. Detti L, Saed GM, Fletcher NM, Kruger ML, Brossoit M, Diamond MP. Endometrial morphology and modulation of hormone receptors during ovarian stimulation for assisted reproductive technology cycles. Fertility and Sterility . 2011; 95(3): 1037-1041. doi: 10.1016/j.fertnstert.2010.12.025
95. Jiang Z, Fletcher NM, Ali-Fehmi R, et al. Modulation of redox signaling promotes apoptosis in epithelial ovarian cancer cells. Gynecologic Oncology. 2011; 122(2): 418-423. doi: 10.1016/j.ygyno.2011.04.051
96. Meng Q, Sun W, Jiang J, Fletcher NM, Diamond MP, Saed GM. Identification of common mechanisms between endometriosis and ovarian cancer. Journal of Assisted Reproduction and Genetics. 2011; 28(10): 917-923.
97. Saed GM, Fletcher NM, Jiang ZL, Abu-Soud HM, Diamond MP. Dichloroacetate induces apoptosis of epithelial ovarian cancer cells through a mechanism involving modulation of oxidative stress. Reproductive Sciences. 18(12): 1253-1261. doi: 10.1177/1933719111411731
98. Maitra D, Byun J, Andreana PR, Abdulhamid I, Saed GM, Diamond MP, Pennathur S, Abu-Soud HM. Mechanism of hypochlorous acid-mediated heme destruction and free iron release. Free Radical Biology and Medicine. 2011; 51(2): 364-373.
99. Maitra D, Byun J, Andreana PR, et al. Reaction of hemoglobin with HOCl: mechanism of heme destruction and free iron release. Free Radical Biology and Medicine. 2011; 51(2): 374-386. doi: 10.1016/j.freeradbiomed.2011.04.011
100. Awonuga AO, Fletcher NM, Saed GM, Diamond MP. Postoperative adhesion development following cesarean and open intra-abdominal gynecological operations: a review. Reproductive Sciences. 2011; 18(12): 1166-1185.
101. White JC, Jiang ZL, Diamond MP, Saed GM. Macrophages induce the adhesion phenotype in normal peritoneal fibroblasts. Fertility and Sterility. 2011; 96(3): 758-763.e3.
102. Souza CE, Maitra D, Saed GM, et al. Hypochlorous acid-induced heme degradation from lactoperoxidase as a novel mechanism of free iron release and tissue injury in inflammatory diseases. PLoS One. 2011; 6(11): e27641. doi: 10.1371/journal.pone.0027641
103. Abu-Soud HM, Maitra D, Byun J, et al. The reaction of HOCl and cyanocobalamin: corrin destruction and the liberation of cyanogens chloride. Free Radical Biology and Medicine. 2012; 52(3): 616-625. doi: 10.1016/j.freeradbiomed.2011.10.496
104. Fletcher NM, Jiang Z, Ali-Fehmi R, et al. Myeloperoxidase and free iron levels: potential biomarkers for early detection and prognosis of ovarian cancer. Cancer Biomarkers. 2012; 10(6): 267-275. doi: 10.3233/CBM-2012-025
105. Shavell VI, Fletcher NM, Jiang ZL, Saed GM, Diamond MP. Uncoupling oxidative phosphorylation with 2,4-dinitrophenol promotes development of the adhesion phenotype. Fertility and Sterility. 2012; 97(3): 729-733. doi: 10.1016/j.fertnstert.2011.12.009
106. Ambler DR, Golden AM, Gell JS, Saed GM, Carey DJ, Diamond MP. Microarray expression profiling in adhesion and normal peritoneal tissues. Fertility and Sterility . 2012; 97(5):1158-1164.e1-4.
107. Maitra D, Abdeulhamid I, Diamond MP, Saed GM, Abu-Soud HM. Melatonin attenuates hypochlorous acid-mediated heme destruction, free iron release, and protein aggregation in hemoglobin. Journal of Pineal Research. 2012; 53(2): 198-205. doi: 10.1111/j.1600-079X.2012.00988.x
108. Ambler DR, Fletcher NM, Diamond MP, Saed GM. Effects of hypoxia on the expression of inflammatory markers IL-6 and TNF-a in human normal peritoneal and adhesion fibroblasts. Systems Biology and Reproductive Medicine. 2012; 58(6): 324-329. doi: 10.3109/19396368.2012.713439
109. Abu-Soud HM, Maitra D, Byun J, et al. The reaction of HOCl and cyanocobalamin: corrin destruction and the liberation of cyanogen chloride. Free Radical and Biological Medicine. 2012; 52(3):616-625.
110. Maitra D, Shaeib F, Abdulhamid I, et al. Myeloperoxidase acts as a source of free iron during steady-state catalysis by a feedback inhibitory pathway. Free Radical and Biological Medicine. 2013; 63:90-98.
111. Banerjee J, Shaeib F, Maitra D, et al. Peroxynitrite affects the cumulus cell defense of metaphase II mouse oocytes leading to disruption of the spindle structure in vitro. Fertility and Sterility. 2013; 100(2):578-584.e1.
112. Detti L, Uhlmann RA, Fletcher NM, Diamond MP, Saed GM. Endometrial signaling pathways during ovarian stimulation for assisted reproduction technology. Fertility and Sterility. 2013; 100(3): 889-894. doi: 10.1016/j.fertnstert.2013.05.027
113. Fletcher NM, Saed MG, Abu-Soud HM, Al-Hendy A, Diamond MP, Saed GM. Uterine fibroids are characterized by an impaired antioxidant cellular system: potential role of hypoxia in the pathophysiology of uterine fibroids. Journal of Assisted Reproductive Genetics. 2013; 30(7):969-974.
114. Nair S, Saed GM, Atta HM, et al. Towards gene therapy of postoperative adhesions: fiber and transcriptional modifications enhance adenovirus targeting towards human adhesion cells. Gynecologic and Obstetric Investigation. 2013; 76(2): 119-124. doi: 10.1159/000353426
115. Detti L, Uhlmann RA, Lu M, et al. erum markers of ovarian reserve and ovarian histology in adult mice treated with cyclophosphamide in pre-pubertal age. Journal of Assisted Reproduction and Genetics. 2013; 30(11): 1421-1429. doi: 10.1007/s10815-013-0087-x
116. Fletcher NM, Saed MG, Abu-Soud HM, Al-Hendy A, Diamond MP, Saed GM. Uterine fibroids are characterized by an impaired antioxidant cellular system: potential role of hypoxia in the pathophysiology of uterine fibroids. 2013.
117. Belotte J, Fletcher NM, Awonuga AO, et al. The role of oxidative stress in the development of Cisplatin resistance in epithelial ovarian cancer. Reproductive Sciences. 2014; 21(4): 503-508. doi: 10.1177/1933719113503403
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