Francesco Vetri, MD, PhD

Department of Anesthesiology
University of Illinois Hospital and Health Sciences System
1740 West Taylor Street Suite 3200 W
Chicago, IL 60612, USA


Dr. Francesco obtained his Medical Degree at the University of Pisa Medical School, in Italy in 2003, followed by a PhD in Basic and Development Neurological Sciences at the University of Pisa (2007). He worked as a Post-Graduate Research Assistant in the Department of Physiological Sciences, University of Pisa, and then as a Post-doctoral Fellow at the National Research Council of Italy (CNR), in Pisa, Italy.
In 2007, he joined the Neuroanesthesia Research Laboratory at the University of Illinois at Chicago, as a Post-doctoral Research Associate.
In 2012, he matched in the Anesthesia residency program at the University of Illinois at Chicago, with graduation in 2016.

Research Interest

His research interests include: Mechanisms underlying neurovascular during physiologic and pathologic conditions such as diabetes, with particular attention to potassium channels. Another topic is the involvement of neuroinflammation in ischemic and hemorrhagic stroke models, exploring the potential clinical application of immunomodulatory molecules.

Scientific Activities


•(2015) Travel award to attend the SNACC meeting in San Diego, USA
•(2015) Finalist for best resident abstract award, International Anesthesia Research Society meeting in Honolulu
•(2008) Travel award to attend the Gordon Research Conference on Brain Energy Metabolism and Blood Flow in Andover, NH, USA
•(1996-2003) Full tuition merit scholarships from Tuscany Region


• American Society of Anesthesiologists (ASA)
• Society for neuroanesthesia and critical care (SNACC)
• International Anesthesia research Society (IARS)
• International Society for Cerebral Blood Flow and Metabolism (ISCBFM)
• Society for Neuroscience (SfN)
• American Physiological Society (APS)


Selected Peer-Reviewed Publications (in chronological order)

1. Xu HL, Garcia M, Testai F, et al. Pharmacologic blockade of vascular adhesion protein-1 lessens neurologic dysfunction in rats subjected to subarachnoid hemorrhage. Brain Res. 2014; 1586: 83-89. doi: 10.1016/j.brainres.2014.08.036
2. Vetri F, Chavez R, Xu HL, Paisansathan C, Pelligrino DA. Complex modulation of the expression of PKC isoforms in the rat brain during chronic type 1 diabetes mellitus. Brain Res. 2013; 1490: 202-209. doi: 10.1016/j.brainres.2012.10.032
3. Watcharotayangul J, Mao L, Xu H, et al. Post-ischemic vascular adhesion protein-1 inhibition provides neuroprotection in a rat temporary middle cerebral artery occlusion model. J Neurochem. 2012; 123(Suppl 2): 116-124. doi: 10.1111/j.1471-4159.2012.07950.x
4. Vetri F, Xu HL, Paisansathan C, Pelligrino DA. Impairment of neurovascular coupling in type 1 diabetes mellitus in rats is linked to PKC modulation of BKCa and Kir channels. Am J Physiol Heart Circ Physiol. 2012; 302(6): H1274-H1284. doi: 10.1152/ajpheart.01067.2011
5. Vetri F, Xu HL, Mao L, Paisansathan C, Pelligrino DA. ATP hydrolysis pathways and their contributions to pial arteriolar dilation in rats. Am J Physiol Heart Circ Physiol. 2011; 301(4): H1369-H1377. doi: 10.1152/ajpheart.00556.2011
6. Pelligrino DA, Vetri F, Xu HL. Purinergic mechanisms in gliovascular coupling. Semin Cell Dev Biol. 2011; 22(2): 229-236. doi: 10.1016/j.semcdb.2011.02.010.
7. Paisansathan C, Xu H, Vetri F, Hernandez M, Pelligrino DA. Interactions between adenosine and potassium channel-related pathways in the coupling of somatosensory activation and pial arteriolar dilation. Am J Physiol Heart Circ Physiol. 2010; 299(6): H2009-H2017. doi: 10.1152/ajpheart.00702.2010
8. Shen B, Vetri F, Mao L, Xu HL, Paisansathan C, Pelligrino DA. Aldose reductase inhibition ameliorates the detrimental effect of estrogen replacement therapy on neuropathology in diabetic rats subjected to transient forebrain ischemia. Brain Res. 2010; 1342: 118-126. doi: 10.1016/j.brainres.2010.04.032
9. Gómez-Gonzalo M, Losi G, Chiavegato A, et al. An excitatory loop with astrocytes contributes to drive neurons to seizure threshold. PLoS Biol. 2010; 8(4): e1000352. doi: 10.1371/journal.pbio.1000352
10. Pelligrino DA, Xu HL, Vetri F. Caffeine and the control of cerebral hemodynamics. J Alzheimers Dis. 2010; 20(Suppl 1): S51-S62. doi: 10.3233/JAD-2010-091261
11. Xu HL, Vetri F, Lee H.K, et al. Estrogen replacement therapy in diabetic ovariectomized female rats potentiates postischemic leukocyte adhesion in cerebral venules via a RAGE-related process. Am J Physiol Heart Circ Physiol. 2009; 297(6): H2059-H2067. doi: 10.1152/ajpheart.00445.2009
12. Xu HL, Mao L, Ye S, Paisansathan C, Vetri F, Pelligrino DA. Astrocytes are a key conduit for upstream signaling of vasodilation during cerebral cortical neuronal activation in vivo. Am J Physiol Heart Circ Physiol. 2008; 294(2): H622-H632. doi: 10.1152/ajpheart.00530.2007
13. Vetri F, Menicucci D, Lapi D, Gemignani D, Colantuoni A. Pial arteriolar vasomotion changes during cortical activation in rats. NeuroImage. 2007; 38(1): 25-33. doi: 10.1016/j.neuroimage.2007.07.017
14. Vetri F. Lost in translation. Anesthesiol Open Journal. 2015; 1(1): 1. doi: 10.17140/AOJ-1-101