Francesca Guida, PhD

Department of Experimental Medicine
Division of Pharmacology
Second University of Naples, Italy



• (2009-2015), Neuropharmacology (Post-Doc) Second University of Naples, Italy
• (2007-2009), Pharmacology (PhD) Second University of Naples, Italy, Kings College, London, UK
• (2005) Pharmacy, University of Naples Federico II, Italy

Research Interest

His research interest include: Pain, Behaviour, Glia.

Scientific Activities


1. Peduto A, Krauth V, Collarile S, et al. Exploring the role of chloro and methyl substitutions in 2-phenylthiomethyl-benzoindole derivatives for 5-LOX enzyme inhibition. Eur J Med Chem. 2016; 108: 466-475. doi: 10.1016/j.ejmech.2015.11.048
2. Aiello F, Badolato M, Pessina F, et al. Design and Synthesis of New Transient Receptor Potential Vanilloid Type-1 (TRPV1) Channel Modulators: Identification, Molecular Modeling Analysis, and Pharmacological Characterization of the N-(4-Hydroxy-3-methoxybenzyl)-4-(thiophen-2-yl)butanamide, a Small Molecule Endowed with Agonist TRPV1 Activity and Protective Effects against Oxidative Stress. ACS Chem Neurosci. 2016; 7(6): 737-748. doi: 10.1021/acschemneuro.5b00333
3. Moriello AS, Luongo L, Guida F, et al. Chalcone derivatives activate and desensitize the transient receptor potential ankyrin 1 cation channel, subfamily A, member 1 TRPA1 ion channel: structure-activity relationships in vitro and anti-nociceptive and anti-inflammatory activity in vivo. CNS Neurol Disord Drug Targets. 2016. Web site. Accessed
4. Palazzo E, Luongo L, Guida F, Marabese I, Romano R, Iannotta M, Rossi F, D Aniello A, Stella L, Marmo F, Usiello A, de Bartolomeis A, Maione S, de Novellis V. D-Aspartate drinking solution alleviates pain and cognitive impairment in neuropathic mice. Amino Acids. 2016; 48(7): 1553-1567. doi: 10.1007/s00726-016-2205-4
5. Guida F, Luongo L, Marmo F, et al. Palmitoylethanolamide reduces pain-related behaviors and restores glutamatergic synapses homeostasis in the medial prefrontal cortex of neuropathic mice. Mol Brain. 2015; 8: 47. doi: 10.1186/s13041-015-0139-5
6. Rinaldi B, Guida F, Furiano A, Donniacuo M, Luongo L, Gritti G, Urbanek K, Messina G, Maione S, Rossi F, de Novellis V. Effect of Prolonged Moderate Exercise on the Changes of Nonneuronal Cells in Early Myocardial Infarction. Neural Plast. 2015; 2015: 265967. doi: 10.1155/2015/265967
7. Sagheddu C, Aroni S, De Felice M, et al. Enhanced serotonin and mesolimbic dopamine transmissions in a rat model of neuropathic pain. Neuropharmacology. 2015; 97: 383-393. doi: 10.1016/j.neuropharm.2015.06.003
8. Spaziano G, Luongo L, Guida F, et al. Exposure to Allergen Causes Changes in NTS Neural Activities after Intratracheal Capsaicin Application, in Endocannabinoid Levels and in the Glia Morphology of NTS. Biomed Res Int. 2015; 2015: 980983. doi: 10.1155/2015/980983
9. Guida F, Lattanzi R, Boccella S, et al. PC1, a non-peptide PKR1-preferring antagonist, reduces pain behavior and spinal neuronal sensitization in neuropathic mice. Pharmacol Res. 2015, 91: 36-46. doi: 10.1016/j.phrs.2014.11.004
10. Boccella S, Vacca V, Errico F, et al. D-aspartate modulates nociceptive-specific neuron activity and pain threshold in inflammatory and neuropathic pain condition in mice. Biomed Res Int. 2015; 2015: 90590. doi: 10.1155/2015/905906
11. Luongo L, Guida F, Imperatore R, et al. The A1 adenosine receptor as a new player in microglia physiology. Glia. 2014; 62(1): 122-132. doi: 10.1002/glia.22592
12. Stella L, Guida F, Nava E, et al. Evaluation and cost analysis in two groups of patients who had been randomized for toxicological monitoring. Heroin Addiction and Related Clinical Problems. 2014; 4(57-62).
13. Rossi F, Bernardo ME, Bellini G, et al. The cannabinoid receptor type 2 as mediator of mesenchymal stromal cell immunosuppressive properties. PLoS One. 2013; 8(11): e80022. doi: 10.1371/journal.pone.0080022
14. Ligresti A, Martos J, Wang J, et al. Prostamide F 2α receptor antagonists with inhibitory activity at FAAH: a way to prevent the confounding effects of pro-inflammatory mediators formed following selective FAAH inhibition? Br J Pharmacol. 2013.
15. Rossi F, Bellini G, Torella M, et al. The genetic ablation or pharmacological inhibition of TRPV1 signaling is beneficial in the restoration of quiescent osteoclast activity in ovariectomized mice. Br J Pharmacol. 2013; 171(10): 2621-2630. doi: 10.1111/bph.12542
16. Rossi F, Marabese I, De Chiaro M, et al. Dorsal striatum metabotropic glutamate receptor 8 affects nocifensive responses and rostral ventromedial medulla cell activity in neuropathic pain conditions. J Neurophysiol. 2013; 111(11): 2196-2209. doi: 10.1152/jn.00212.2013
17. Maione S, Costa B, Piscitelli F, et al. Piperazinyl carbamate fatty acid amide hydrolase inhibitors and transient receptor potential channel modulators as “dual-target” analgesics. Pharmacol Res. 2013; 76: 98-105. doi: 10.1016/j.phrs.2013.07.003
18. Descalzi F, Ulivi V, Cancedda R, et al. Platelet-rich plasma exerts antinociceptive activity by a peripheral endocannabinoid-related mechanism. Tissue Eng Part A. 2013; 19(19-20): 2120-2129. doi: 10.1089/ten.TEA.2012.0557
19. Caraglia M, Luongo L, Salzano G, et al. Stealth liposomes encapsulating zoledronic acid: a new opportunity to treat neuropathic pain. Mol Pharm. 2013; 10(3): 1111-1118. doi: 10.1021/mp3006215
20. Luongo L, Guida F, Boccella S, et al. Palmitoylethanolamide Reduces Formalin-Induced Neuropathic-Like Behaviour Through Spinal Glial/Microglial Phenotypical Changes in Mice. CNS Neurol Disord Drug Targets. 2013; 12(1): 45-54. doi: 10.2174/1871527311312010009
21. Citraro R, Russo E, Scicchitano F, et al. Antiepilepticaction of N-palmitoylethanolaminethrough CB1 and PPAR-α receptor activation in a genetic model of absence epilepsy. Neuropharmacology. 2013; 69: 115-126. doi: 10.1016/j.neuropharm.2012.11.017
22. Luongo L, Petrelli R, Gatta L, et al. 5-Chloro-5-deoxy-ENBA, a Potent and Selective Adenosine A1 ReceptorAgonist, Alleviates NeuropathicPain in Mice Through Functional Glial and Microglial Changes without Affecting Motor or Cardiovascular Functions. Molecules. 2012; 17(12): 13712-13726. doi: 10.3390/molecules171213712
23. Rossi F, Bellini G, Luongo L, et al. The 17-β-oestradiol inhibits osteoclast activity by increasing the cannabinoid CB2 receptor expression. Pharmacol Res. 2012; 68(1): 7-15. doi: 10.1016/j.phrs.2012.10.017
24. Guida F, Luongo L, Aviello G, et al. A reduces mechanical allodynia and spinal neuronal hyperexcitability induced by peripheral formalin injection. Mol Pain. 2012; 8: 60. doi: 10.1186/1744-8069-8-60
25. Luongo L, de Novellis V, Gatta L, et al. Role of metabotropic glutamate receptor 1 in the basolateral amygdala-driven prefrontal cortical deactivation in inflammatory pain in the rat. Neuropharmacology. 2012; 66: 317-329. doi: 10.1016/j.neuropharm.2012.05.047
26. Luongo L, Costa B, D-Agostino B, at al. Palvanil, a non-pungent capsaicin analogue, inhibits inflammatory and neuropathic pain with little effects on bronchopulmonary function and body temperature. Pharmacol Res. 2012; 66(3): 243-250. doi: 10.1016/j.phrs.2012.05.005
27. Pasquini S, Mugnaini C, Ligresti A, et al. Design, Synthesis, and Pharmacological Characterization of Indol-3-ylacetamides, Indol-3-yloxoacetamides, and Indol-3-ylcarboxamides: Potent and Selective CB2 Cannabinoid Receptor Inverse Agonists. J MedChem. 2012; 55(11): 5391-5402. doi: 10.1021/jm3003334
28. Palazzo E, Luongo L, Bellini G, et al. Changes in cannabinoid receptor subtype 1 activity and interaction with metabotropic glutamate subtype 5 receptors in the periaqueductal gray-rostral ventromedial medulla pathway in a rodent neuropathic pain model.CNS Neurol Disord Drug Targets. 2012; 11(2): 148-161. doi: 10.2174/187152712800269731
29. Mugnaini C, Nocerino S, Pedani V, et al. Investigations on the 4-quinolone-3-carboxylic acid motif part 5: modulation of the physicochemical profile of a set of potent and selective cannabinoid-2 receptor ligands through a bioisosteric approach. ChemMedChem. 2012; 7(5): 920-934. doi: 10.1002/cmdc.201100573
30. Lattanzi R, Sacerdote P, Franchi S, et al. Pharmacological activity of a Bv8 analogue modified in position 24. Br J Pharmacol. 2012; 166(3): 950-963. doi: 10.1111/j.1476-5381.2011.01797.x
31. de Novellis V, Luongo L, Guida F, et al. Effects of intra-ventrolateral periaqueductal grey palmitoylethanolamide on thermoceptive threshold and rostral ventromedial medulla cell activity. Eur J Pharmacol. 2012; 676(1-3): 41-50. doi: 10.1016/j.ejphar.2011.11.034
32. Palazzo E, Guida F, Gatta L, et al. EP1 receptor within the ventrolateral periaqueductal grey controls thermonociception and rostral ventromedial medulla cell activity in healthy and neuropathic rat. Mol Pain. 2011; 7: 82. doi: 10.1186/1744-8069-7-82
33. De Petrocellis L, Guida F, Moriello AS, et al. N-palmitoyl-vanillamide (palvanil) is a non-pungent analogue of capsaicin with stronger desensitizing capability against the TRPV1 receptor and anti-hyperalgesic activity. Pharmacol Res. 2011; 63(4): 294-299. doi: 10.1016/j.phrs.2010.12.019
34. Soukupova M, Palazzo E, Chiaro MD, et al. Effects of URB597, an inhibitor of fatty acid amide hydrolase (FAAH), on analgesic activity of paracetamol. Neuro EndocrinolLett. 2010; 31(4): 507-511. Web site. Accessed
35. Pasquini S, De Rosa M, Pedani V, et al. Investigations on the 4-quinolone-3-carboxylic acid motif. 4. Identification of new potent and selective ligands for the cannabinoid type 2 receptor with diverse substitution patterns and antihyperalgesic effects in mice. J Med Chem. 2011; 54(15): 5444-5453. doi: 10.1021/jm200476p
36. Aviello G, Borrelli F, Guida F, et al. Capasso R Ultrapotent effects of salvinorin A, a hallucinogenic compound from Salvia divinorum, on LPS-stimulated murine macrophages and its anti-inflammatory action in vivo. J Mol Med. 2011; 89(9): 891-902. doi: 10.1007/s00109-011-0752-4
37. Pasquini S, Ligresti A, Mugnaini C, et al. Investigations on the 4-quinolone-3-carboxylic acid motif. 3. Synthesis, structure-affinity relationships, and pharmacological characterization of 6-substituted 4-quinolone-3-carboxamides as highly selective cannabinoid-2 receptor ligands. J Med Chem. 2010; 53(16): 5915-5928. doi: 10.1021/jm100123x
38. Clark AK, Wodarski R, Guida F, Sasso O, Malcangio M. Cathepsin S release from primary cultured microglia is regulated by the P2X7 receptor. Glia. 2010; 58(14): 1710-1726. doi: 10.1002/glia.21042
39. Palazzo E, Rimoli MG, De Chiaro M, et al. Intra-periaqueductal grey microinjections of an imidazo [1,2-b] pyridazine derivative, DM2, affects rostral ventromedial medulla cell activity and shows antinociceptive effect. Neuropharmacology. 2009; 58(3): 660-667. doi: 10.1016/j.neuropharm.2009.11.006
40. Palazzo E, Guida F, Migliozzi A, et al. Intra-Periaqueductal Gray glycine decreases or increases the activity of Rostral Ventromedial Medulla ON and OFF cell respectively and enhances thermoceptive threshold in the rat. J Neurophysiol. 2009; 102(6): 3169-3179.
41. Brizzi A, Brizzi V, Cascio MG, et al. New resorcinol-anandamide “hybrids” as potent cannabinoid receptor ligands endowed with antinociceptive activity in vivo. J MedChem. 2009; 52(8): 2506-2514. doi: 10.1021/jm8016255
42. Maione S, Starowicz K, Cristino L, et al. Functional Interaction Between TRPV1 and {micro}-Opioid Receptors in the Descending Antinociceptive Pathway Activates Glutamate Transmission and Induces Analgesia. J Neurophysiolo. 2009; 101(5): 2411-2422. doi: 10.1152/jn.91225.2008
43. Palazzo E, Rossi F, De Petrocellis L, et al. The analgesic effect of N-arachidonoyl-serotonin, a FAAH inhibitor and TRPV1 receptor antagonist, associated with changes in rostral ventromedial medulla and locus coeruleus cell activity in rats. Neuropharmacology. 2008; 55(7): 1105-1113. doi: 10.1016/j.neuropharm.2008.06.023
44. Marabese I, Rossi F, Palazzo E, de Novellis V, Starowicz K, Cristino L, Vita D, Gatta L, Guida F, Di Marzo V, Rossi F, Maione S. Periaqueductal gray metabotropic glutamate receptor subtype 7 and 8 mediate opposite effects on amino acid release, rostral ventromedial medulla cell activities, and thermal nociception. J Neurophysiol. 2007; 98(1): 43-53. doi: 10.1152/jn.00356.2007