Effiong E. Otukonyong, PhD, MSc, B.MedSc
Department of Health Sciences
College of Public Health
East Tennessee State University
P. O. Box 70673 Johnson City, TN 37614, USA
Dr. Otukonyong, completed his PhD training in the Department of Neuroscience in Kochi Medical School, Kochi, Japan in 2001 with a research focus on the Neurobiology of leptin and Nitric oxide. On completion of his study, he was offered a Postdoctoral Fellowship in the Department of Neuroscience, McKnight Brain Institute at Gainesville, University of Florida between 2001-2003, where he researched on various appetite regulatory hormones, with particular interest in adipocyte-derived leptin, a satiety hormone that regulate appetite and body weight homeostasis. Over the years, he has studied the hypothalamus where leptin is also produced and exerts its effect centrally. He has used various forms of leptin in his research including recombinant leptin and recombinant adeno-associated virus encoding leptin (rAAV-lep). He is a member of various professional bodies including the Society for Neuroscience (SfN) and American Association for Advancement of Science (AAAS). Aside from the hypothalamus, he will continue to explore the brain library with the hope of finding other brain sites that respond to leptin in the control of body weight homeostasis. In his laboratory, success have been recorded with leptin in ameliorating obesity in lower animals. Presently, he is an Assistant Professor in the Department of Health Sciences, College of Public Health in East Tennessee State University.
His research interests include the Neuroendocrinology/Neurobiology of obesity, Neurobiology of stroke as well as the role of Leptin in Metabolism and Reproduction.
OTHER EXPERIENCE & PROFESSIONAL MEMBERS
1998-2001, Teaching Assistant, Department of Physiology, Kochi Medical School, Japan
1998-2001, Research Assistant, Department of Physiology, Kochi Medical School, Japan
1997-Date, Member, Physiological Society of Japan
1997-Date, Member, Neuroscience Society of Japan
2001-Date, Member, Society for Neuroscience, USA
2011- Date, Member Tennessee Physiological Society, USA
2012-Date, Member American Association for Advancement of Science, USA
1996-2001, Japanese Government Scholar (Mombusho Scholarship)
2001, Best Graduating Student in Kochi Medical School, Japan
SOME CONFERENCES ATTENDED AND PAPERS PRESENTED:
1. Otukonyong EE, Johnstone LE, Higuchi T. Relationship among food intake, energy balance and reproduction in the female rats. 73rd meeting of the Japanese Physiological Society, Hamamatsu, Japan,1997.
2. Otukonyong EE, Okere CO, Higuchi T. effect of suckling on nitric oxide synthase (NOS) activity in the PVN and SON in the lactating rats. 74th Annual meeting of the Japanese Physiological Society, Tokyo, Japan, 1998.
3. Otukonyong EE, Okutani F, Takahashi S, Kaba H, Higuchi T. Effects of food deprivation and leptin repletion on the plasma levels of Estrogen (E2) and NADPH-diaphorase reactivity in the ventromedial and arcuate nuclei in the female rats. 75th Annual meeting of the Japanese Physiological Society, Nagasaki, Japan, 2000
4. Otukonyong EE, Okutani F, takahashi S, Kaba H, Higuchi T. Effects of fasting and leptin repletion on the preoptic and hypothalamic nuclei to increase the plasma LH and prevents a fasting-induced delay in the estrous cycles in the female rats. 78th Annual meeting of the Japanese Physiological Society, Kyoto, Japan, 2001.
5. Otukonyong EE, Torto R, dube MG, Kalra PS, Kalra SP. Altered rhythmicity in peripheral hormonal feedback may encode dietary obesity. Presented at the 33rd Annual meeting of Society for Neuroscience, New Orleans, Louisiana, USA November 2003, Program # 283.10.
6. Otukonyong EE, Oyebola DD. Electrolyte loss in apparently healthy Nigerians. Physiological meeting, Ibadan, Nigeria 1993.
7. Otukonyong EE, Effraim KD. Distribution of Dehydrogenase-6-phosphate enzymes in the student’s population of the college of medical sciences, University of Maiduguri. 2ndOlumba Bashir Conference, Maiduguri 1994.
8. Enyikwola O, Otukonyong EE, Hussany A, Akinniyi A. effects of extract of Roselle Hibiscus (Hibiscus Subdariffa) on the gastric acid secretion in Albino rats. Physiological Society Meeting, Jos, Nigeria 1995.
9. Otukonyong E, Moore BL, Thomas NI, Breuel KF. Central leptin blocks high-fat diet-induced weight gain and modulates metabolic hormones. Presented at the 41st Annual Society of Neuroscience Meeting, November 12-16, Washington DC, USA 2011.
10. Otukonyong EE, Moore B, Thomas IE, Breuel KF. Intracerebroventricular leptin Stimulates milk ejection from lactating breast. Presented at the 42nd Annual Society of Neuroscience Meeting, October 13-17, New Orleans Louisiana, USA 2012.
11. Otukonyong EE, Olufunke S, Campbell S. Thomas IN. Systemic leptin modulates the expression of E-cadherin and Beta-catenin in the ovary of dietary-induced obese infertile rats. Presented at the 43rd Annual Society of Neuroscience Meeting, November 9-13, San Diego California, USA 2013.
Selected Peer-Reviewed Publications (In Descending Order)
1. Otukonyong E, Okere C, Johnston L, Murata T, Kaba H, Higuchi T. Effect of Suckling on NADPH-diaphorase Nitric oxide synthase NOS reactivity and NOS gene expression in the paraventricular and supraoptic nuclei of lactating rats. Journal of Neuroendocrinology. 2000; 10: 1001-1008. doi: 10.1046/j.1365-2826.2000.00548.x
2. Otukonyong E, Okutani F, Takahashi S, et al. Effect of food Deprivation and leptin repletion on the plasma levels of estrogen E2 and NADPH-d reactivity in the ventromedial and arcuate nuclei of the hypothalamus in the female rats. Brain Research. 2000; 887: 70-79. doi: 10.1016/S0006-8993(00)02969-3
3. Okatani Y, Wakatsuki A, Otukonyong E, Miyahara Y. Effects of prenatal melatonin exposure on gonadotropins and prolactin secretion in male and female rat pups. Eur J Pharmacol. 2001; 424: 229-235. doi: 10.1016/S0014-2999(01)01176-1
4. Kalra S, Bagnasco M, Otukonyong E, Dube M, Kalra P. Rhythmic, Reciprocal Ghrelin and leptin signaling: New Insight in the Development of Obesity. Regulatory Peptides. 2003; 111: 1-11. doi: 10.1016/S0167-0115(02)00305-1
5. Otukonyong E, Dube M, Torto R, Kalra P, Kalra S. High-fat diet-induced ultra dianleptin and insulin hyperseceretion and ghrelin hyposecretion is absent in obesity resistant rats. Obesity Research. 2005; 13(6): 1-9.
6. Otukonyong E, Dube M, Kalra P, Kalra S. Central leptin differentially modulates ultradian secretory patterns of insulin leptin and ghrelin independent of effects on food intake and body weight. Peptides. 2005; 26: 2559-2566. doi: 10.1016/j.peptides.2005.04.015
7. Otukonyong E, Torto R, Dube M, Kalra P, Kalra S. Altered rhythmicity in peripheral hormonal feedback may encode dietary obesity. Neuroscience. 2003.
8. Nathaniel T, Otukonyong E, Bwint S, et al. Clinical Neuroprotection against tissue Hypoxia during Brain Injuries the challenges and targets. Curr Drug targets CNS Neurol Disord. 2011; 4: 325- 329. doi: 10.5772/28121
9. Thomas I, Nathaniel T, Otukonyong E, Abdellatif A, Soyinka J. Effect of Hypoxia on metabolic rate, core body temperature and c-fos expression in the naked mole rat. International Journal of Developmental Neuroscience. 2012; 30: 539-544. doi: 10.1016/j.ijdevneu.2012.04.004
10. Thomas I, Effiong E, Otukonyong E, et al. Metabolic regulatory Clues from the naked mole rat: Toward brain regulatory functions during stroke. Brain Research Bulletin. 2013; 98: 44-52. doi: 10.1016/j.brainresbull.2013.07.008
11. Otukonyong E, Moore B, Thomas N, Breuel K. Central leptin blocks high fat diet induced weight gain and modulates metabolic hormones. Neuroscience. 2011.
12. Otukonyong E, Moore B, Thomas I, Breuel K. Intracerebroventricular leptin Stimulates milk ejection from lactating breast. Neuroscience. 2012.
13. Otukonyong E, Olufunke S, Campbell, Nathaniel T. Systemic leptin modulates the expression of E-cadherin and beta-catenin in the ovary of dietary induced obese infertile rats. Neuroscience. 2013.
14. Otukonyong E, Campbel S, Nathaniel T. Recombinant leptin up-regulates the secretion of luteinizing hormone and the expression of E-cadherin and beta catenin in the ovary of dietary induced obese infertile rats: mechanism of action. Neuroscience. 2014.
15. Nathaniel T, Okon M, Akinwole T, Otukonyong E, Nathaniel A, Why C. fos matters in the bedside treatment of stroke A new clue in the development of a tolerant brain against ischemic stroke. Neuroscience. 2014.
16. Otukonyong E, Olufunke S, Campbell S, Thomas I. Systemic leptin modulates the expression of E cadherin and Beta catenin in the ovary of dietary-induced obese infertile rats. Research forum. 2013.
17. Moore B, Otukonyong E, Kelvin B. Intracerebroventricular leptin depletes abdominal fat to suppress body weight: an insight in the treatment of obesity syndrome. Research forum. 2011.
18. Kaidal A, Mbarjiorgu F, Otukonyong E. Effects of soccer participation on the menstrual functions of female footballers in Borno State. Annals of Borno. 1993; 10: 128-133.
19. Enyikwola O, Otukonyong E, Hussainy A, Akiniyi J. Effects of saline extracts of Rosselle (Hibiscus Subdariffa) on gastric acid secretion in Albino rats. Nigerian Journal of Physiological Sciences. 1993; 9: 39-4415.
20. Otukonyong E, Oyebola D. Electrolyte loss during exercise in Apparently Healthy Nigerians. Central African Journal of Medicine. 1994; 40: 74-77.
21. Falusi A, Ademowo O, Latunji C, Okeke A, Otukonyong E. Distribution of ABO and RH genes in Nigeria. African Journal of Medical Sciences. 2000; 29: 23-26.