Samad Farashi-Bonab, PhD

Department of Immunology
School of Medicine
Tehran University of Medical Sciences
Tehran 1417613151, Iran

E-mail: samadfa@health.missouri.edu

Biography

Dr. Samad Farashi-Bonab is a researcher in the field of cancer therapy. He earned his DVM degree from the Azad University (2005) and followed by earning his PhD in Microbiology and Immunology from the University of Tehran and the Tehran University of Medical Science (2014). In his thesis work he prepared an anticancer dendritic cell vaccine and ex vivo propagated T cells to treat fibrosarcoma tumor. After completing his PhD, he was offered post-doctoral position in molecular immunology at the Children’s Medical Center Hospital and in cancer immunotherapy at the Department of Immunology, Tehran University of Medical Sciences, Tehran. He formerly worked in the Northwest biotechnology institute (2005-2006) and in Hospital’s diagnostic medical laboratory (2015-2016). He is also a university lecturer and has taught Immunology, Bacteriology, Bacterial diseases, Virology and viral diseases to students. His main research areas are vaccine development and cancer immunotherapy.

Education

• (2005-2012) PhD, ‘Anthropology’ from University of Delhi
• (1999-2005) DVM, Azad University

Research Interest

His research interests include: Tumor immunology, Cancer immunotherapy, Immunopharmacology, Immunology of bacterial and viral diseases, Molecular detection of infectious diseases, Vaccine development

Scientific Activities

Publications

1. Salehi S, Shahi A, Afzali S, Keshtkar A, Farashi-Bonab S, Soleymanian T, et al. Transitional immature regulatory B cells and regulatory cytokines can discriminate chronic antibody-mediated rejection from stable graft function. Int Immunopharmacol. 2020; 86: 106750. doi: 10.1016/j.intimp.2020.106750
2. Jafari D, Noorbakhsh F, Delavari A, Tavakkoli-Bazzaz J, Farashi-Bonab S, Abdollahzadeh R, et al. Expression level of long noncoding RNA NKILA-miR103-miR107 inflammatory axis and its clinical significance as potential biomarker in patients with colorectal cancer. J Res Med Sci.2020; 25(1): 41. doi: 10.4103/jrms.JRMS_943_19
3. Farashi-Bonab S, Sarrafnejad A, Khansari N. Coronavirus disease 19, the large-scale coronavirus pandemic. CPQ Microbiology. 2020; 4(1): 1-4.
4. Farashi-Bonab S, Khansari N. Most Frequent Bacteria in Colorectal Cancer Patients and Their Roles in Colorectal Carcinogenesis. CPQ Microbiology. 2020; 3(5): 1-12.
5. Kalantari A, Farashi-Bonab S, Keyvanfar H, Mortazavi P. Evaluation of apoptosis induction by Newcastle disease virus LaSota strain in human breast carcinoma cells. Arch Razi Inst. 2020; 75(3): 367-376. doi: 10.22092/ari.2019.125824.1322
6. Farashi-Bonab S, Khansari N. Salmonella-based anticancer vaccines and their efficacy. Vaccin Res Open J. 2019; 1(1): 65-71.doi: 10.17140/VROJ-1-111
7. Afshari-Behbahanizadeh S, Farashi-Bonab S. Study the effect of indomethacin administration on breast tumor growth and inos gene expression in tumor-bearing mice. Int J Adv Biol Biomed Res. 2019; 7(2): 160-172. doi: 10.33945/SAMI/IJABBR.2019.2.7
8. Farashi-Bonab S, Khansari N. Role of bacterial infection in the development and progression of gastric cancers. MOJ Immunol. 2018; 6(6): 316-321. doi: 10.15406/moji.2018.06.00251
9. Motevaseli E, Khorramizadeh MR, Hadjati J, Farashi-Bonab S, Eslami S, Ghafouri-Fard S. Investigation of antitumor effects of Lactobacillus crispatus in experimental model of breast cancer in BALB/c mice. Immunotherapy. 2018; 10(2): 119-129. doi: 10.2217/imt-2017-0088
10. Farashi-Bonab S, Khansari N. Anticancer dendritic cell vaccines producing effective antitumor T-cell responses. Int J Vaccines Vaccin. 2017; 4(3): 00081. doi: 10.15406/ijvv.2017.04.00081
11. Farashi-Bonab S, Khansari N. Immunobiology of anticancer virotherapy with Newcastle disease virus in cancer patients. Vaccin Res Open J. 2017; 1(2): 45-53. doi: 10.17140/VROJ-1-108
12. Farashi-Bonab S, Khansari N. Virotherapy with newcastle disease virus for cancer treatment and its efficacy in clinical trials. MOJ Immunol. 2017; 5(6): 00176. doi: 10.15406/moji.2017.05.00176
13. Latifynia A, Niknam MH, Farashi-Bonab S, Ansaripour B, Gheflati Z, Gharagozlou MJ. Pre-challenge evaluation of immune response in serum cytokines (Th1 and Th2) and t-cell markers (CD4, CD8, CD3, and CD25) following administration of new formulated leishmania vaccine in Balb/c mice. J Clin Cell Immunol. 2017; 8: 6. doi: 10.4172/2155-9899.1000533
14. Farashi-Bonab S, Khansari N. Dendritic cell maturation is a critical step in dendritic cell vaccine preparation for cancer therapy. Vaccin Res Open J. 2016; 1(1): 25-32. doi: 10.17140/VROJ-1-105
15. Eslami S, Hadjati J, Motevaseli E, Mirzaei R, Farashi-Bonab S, Ansaripour B, Khoramizadeh MR. Lactobacillus crispatus strain SJ-3C-US induces human dendritic cells (DCs) maturation and confers an anti-inflammatory phenotype to DCs. APMIS. 2016; 124(8): 697-710. doi: 10.1111/apm.12556
16. Farashi-Bonab S, Khansari N. Improving of antitumor immunity and therapeutic efficacy of cancer vaccines and adoptive immunotherapies using monoclonal antibodies. MOJ Immunol. 2015; 2(5): 00062. doi: 10.15406/moji.2015.02.00062
17. Farashi-Bonab S, Khansari N. Dendritic cell vaccine and its application in cancer therapy. Int J Vaccines Vaccin. 2015; 1(1): 00002. doi: 10.15406/ijvv.2015.01.00002
18. Farashi-Bonab S, Khansari N. Regulatory T-cells in cancer patients and their roles in cancer development/progression. MOJ Immunol. 2014; 1(4): 00024. doi: 10.15406/moji.2014.01.00024
19. Mohammadpour H, Kaleibar MT, Farashi-Bonab S. Evaluation of BIV and BLV coinfection in slaughtered culling cattle in northwest of Iran. Comp Clin Pathol. 2013; 23: 1111-1115. doi: 10.1007/s00580-013-1749-x
20. Zahraei-Salehi T, Farashi-Bonab S. Antibiotics susceptibility pattern of Escherichia coli strains isolated from chickens with colisepticemia in Tabriz province, Iran. International Journal of Poultry Science. 2006; 5(7): 677-684. doi: 10.3923/ijps.2006.677.684