Chi Chiu Wang, MD, PhD

Professor
Department of Obstetrics & Gynaecology
The Chinese University of Hong Kong
Tai Po Road, Sha Tin
New Territories, Hong Kong

 

Biography

Dr. Wang Chi Chiu is currently the Deputy Director of Prenatal Genetic Diagnosis Centre, and Division Head and Professor of Department of Obstetrics & Gynaecology at CUHK. Dr. Wang joined the department after his MBBS degree with honours in 1994, and in 1998 and 2011, he received his first PhD in Surgical Sciences from the Chinese University of Hong Kong and his second PhD in Genetics from Japan National Institute of Genetics. Dr. Wang has major research focus in studying congenital fetal anomalies and therapeutic intervention. With wide range of experience in clinical diagnosis, medical research and teaching, Dr. Wang was appointed to the editorial boards and review panels of many important research funding agents and journals. He was also a council member of the Hong Kong Society of Medical Genetics. Dr. Wang has worked on many research projects received a total of 45 million research grants and owned 2 patents. He has published over 120 ISI articles on many acclaimed journals including Gene Dev, Proc Natl Acad Sci U S A, Hum Reprod Update, Angiogenesis, Cell Research, J Biol Chem, Free Radical Biol Med, Mol Hum Reprod, Hum Reprod, and Fertil Steril. His success in fetal medicine research has earned him multiple local and international scholarships and awards.

Research Interest

His research interests include: Reproductive Medicine (endometriosis, miscarriage), Developmental Biology (redox control, gene dosage), Maternal Medicine (preeclampsia, gestational diabetes mellitus), Fetal Medicine (fetal hypoxia, prenatal diagnosis).

Scientific Activities

PROFESSIONAL SOCIETIES:

• The Science Advisory Board (SAB, US)
• FRSC (Chemistry, UK) ISSCR (Stem Cell, US)
• ESHRE (Human Reproduction & Embryology, Belgium)
• WES (Endometriosis) WFCMS (Chinese Medicine)
• APSEG (Eye Genetics, Asia Pacific)
• HKSMG (Medical Genetics, HK)
• HKPS (Proteomics, HK)
• HKSDB (Developmental Biology, HK)
• OGSHK (O&G, HK) HKSCC (Clinical Chemistry, HK)
• HKSMS (Mass Spectrometry, HK)

RESEARCH AWARDS & SCHOLARSHIPS:

• C. Y. Kwan/Lee Hysan Foundation Endowment Funds/Sino-British Fellowship Trust Fund, Society for Gynecologic Investigation (SGI)
• Japan Society for the Promotion of Science (JSPS)
• Global Scholarship Programme for Research Excellence – CNOOC
• Marine Biological Laboratory (MBL)
• International Federation of Placental Associations (IFPA)
• International Union of Toxicology (IUTOX)
• International Society for Stem Cell Research (ISSCR)
• International Society for Immunology of Reproduction (ISIR)
• The International Federation of Clinical Chemistry and Laboratory Medicine – Forum of European Societies for Clinical Chemistry and Laboratory Medicine (IFCC-FESCC)
• Asia-Association for Research in Vision and Ophthalmology (ARVO)
• Keystone Symposia, Asian-Pacific Federation of Clinical Biochemists (APFCB)
• Human Genome Organisation (HUGO)
• American Association for Clinical Chemistry (AACC)
• Hong Kong Society of Medical Genetics, Australasian Association of Clinical Biochemists (AACB)
• Asian and Pacific Federation of Clinical Biochemistry (APFCB)
• International Federation of Clinical Chemistry and Laboratory Medicine (IFCCLM)
• Hong Kong Society of Clinical Chemistry, German Academic Exchange Service (DAAD)

Publications

1. Man GCW, Wang WWJ, Yim APY, et al. A review of pinealectomy-induced melatonin-deficient animal models for the study of etiopathogenesis of adolescent idiopathic scoliosis. Int J Mol Sci. 2014; 15: 16484-16499. doi: 10.3390/ijms150916484
2. Chu KO, Chan SO, Pang CP, Wang CC. Pro-oxidative or Anti-oxidative dilemma of phytochemical polyphenols for therapeutic interventions against inflammation and oxidative insults. J Agric Food Chem. 2014; 62: 4026-4038.
3. Li L, Leung PC, Chung TKH, Wang CC. Systematic review of Chinese Medicine for miscarriage during early pregnancy. Evid-Based Compl Alt Med Article. 2014; 1-16. doi: 10.1155/2014/753856
4. Wang CC, Li L, Lau CBS, Leung PC, Fung KP. Pregnancy Outcomes, Embryonic and Fetal Development in Maternal Exposure to Chinese Medicines. Birth Defects Res Part C: Embryo Today. 2013; 99: 275-291. doi: 10.1002/bdrc.21050
5. Chu CY, Wang CC. Toxicity of melamine: The public health concern. J Environ Sci Heal C. 2013; 31(4): 342-386. doi: 10.1080/10590501.2013.844758.
6. Leung TY, Pooh RK, Wang CC, Lau TK, Choy KW. Classification of pathogenic or benign status of CNVs detected by microarray analysis. Expert Rev Mol Diagn. 2010; 10(6): 717-721. doi: 10.1586/erm.10.68.
7. Ufer C, Wang CC, Borchert A, Heydeck D, Kuhn H. Redox control in mammalian embryo development. Antioxid Redox Sign. 2010; 13(6): 833-875. doi: 10.1089/ars.2009.3044.
10.1089/ars.2009.3044 8. Choy KW, Kwok YKY, Cheng YKY, et al. Rapid detection of chromosomal abnormalities by BACs-on-Beads versus karyotyping: a cytogenetic risk assessment: a prospective observational study. BJOG. 2014; 121(10): 1245-1252.
9. Huang YG, Li W, Wang CC, Wu XK, Zheng JH. Cryptotanshinone reverses ovarian insulin resistance in mice through activation of insulin signaling and the regulation of glucose transporters and hormone synthesizing enzymes. Fertil Steril. 2014; 102(2): 589-596. doi: 10.1016/j.fertnstert.2014.05.012
10. Chong WWS, Lo IFM, Lam STS, et al. Performance of chromosomal microarray for patients with intellectual disabilities/developmental delay, autism, and multiple congenital anomalies in a Chinese cohort. Mol Cytogenet. 2014; 7(34): 1-6. doi: 10.1186/1755-8166-7-34. eCollection 2014.
11. Liang J, Ng KY, Cheng QN, Xia Y, Wang CC, Leung PS. Human fetal liver stromal cell co-cultures enhance the differentiation of pancreatic progenitor cells into islet-like cell clusters. Stem Cell Rev Rep. 2013; 10(2): 280-294. doi: 10.1007/s12015-013-9491-y.
12. Wang CC, Man GCW, Chu CY, et al. Serotonin receptor 6 mediates defective brain development in monoamine oxidase-a deficient mouse embryos. J Biol Chem. 2014; 289(12): 8252-8263. doi: 10.1074/jbc.M113.522094.
13. Deng Y, Wang CC, Choy KW, et al. Therapeutic potentials of gene silencing by RNA interference: principles, challenges, and new strategies. Gene. 2013; 538(2): 217-227. doi: 10.1016/j.gene.2013.12.019.
14. Lee WYW, Zhang T, Lau CPY, Wang CC, CHan KM, Li G. Immortalized human fetal bone marrow-derived mesenchymal stromal cell expressing suicide gene for anti-tumor therapy in vitro and in vivo. Cytotherapy. 2013; 15(12): 1484-1497. doi: 10.1016/j.jcyt.2013.06.010
15. Lo P, Chen Y, Mak KKL, Wong CK, Wang CC, Yuan P. Functional role of Mst1/Mst2 in embryonic stem cell differentiation. pLoS One. 2013; 8(11): e79867. doi: 10.1371/journal.pone.0079867.
16. Wang YF, Li L, Wang CC, Leung LK. Effect of zeranol on expression of apoptotic and cell cycle proteins in murine placentae. Toxicology. 2013; 314: 148-154. doi: 10.1016/j.tox.2013.09.011
17. Li P, Chen Y, Meng XM, et al. Suppression of malignancy by Smad3in mouse embryonic stem cell formed teratoma. Stem Cell Rev Rep. 2013; 9: 709-720. doi: 10.1007/s12015-013-9452-5
18. Chan KY, Zhou L, Xiang P, et al. Thrombopoietin protects against myocardial infarction in rats: improved cardiac functions, regulated gene expression profiles of remodeling, promoted endothelial progenitor cells and neovascularization. Int J Cardiol. 2013; 167:2546-2554.
19. Xu H, Zhang T, Man GCW, et al. Angiogenic vascular endothelial growth factor C is expressed in endometrium and promotes endothelial functions, vascular permeability and angiogenesis and growth of endometriosis. Angiogenesis. 2013; 16:541-551. doi: 10.1007/s10456-013-9333-1
20. Li L, Dou LX, Leung PC, Chung TKH, Wang CC. Chinese herbal medicine for unexplained recurrent miscarriage: Protocol. Cochrane DB Syst Rev. 2013; 6: 1-15.
21. Tang WJ, Huang H, Wang YF, Wong TY, Wang CC, Leung LK. Bisphenol A differentially activates protein kinase C isoforms in murine placental tissue. Toxicol Appl Pharm. 2013; 269(2): 163-168. doi: 10.1016/j.taap.2013.03.016
22. Wang CC, Cheng KF, Lo WM, et al. A randomized, double-blind, multiple-dose escalation study of a Chinese herbal medicine preparation (Dang Gui Buxue Tang) for moderate to severe menopausal symptoms and quality of life in postmenopausal women. Menopause. 2013; 20(2): 223-231. doi: 10.1097/gme.0b013e318267f64e
23. Cheng YK, Wong C, Wong HK, et al. The detection of mosaicism by prenatal BoBs™. Prenat Diagn. 2013; 33: 42-49. doi: 10.1002/pd.4006
24. Chu CY, Chu KO, Ho CS, et al. Melamine in prenatal and postnatal organs in rats. Reprod Toxicol. 2013; 35:40-47. doi: 10.1016/j.reprotox.2012.06.003
25. Wang CC, Xu H, Man GCW, et al. Prodrug of green tea epigallocatchin-3-gallate (Pro-EGCG) as a potent anti-angiogenesis agent for endometriosis in mice. Angiogenesis. 2013; 16: 59-69. doi: 10.1007/s10456-012-9299-4
26. Tang LY, Li L, Borchert A, Lau CBS, Leung PC, Wang CC. Molecular studies of the congenital malformation induced by Largehead Atractylodes Rhizome, the most commonly used Chinese medicine for threatened miscarriage. Mol Hum Reprod. 2012; 18(12): 585-592. doi: 10.1093/molehr/gas034
27. Lee LM, Leung CY, Tang WW, et al. A paradoxical teratogenic mechanism for retinoic acid. Proc Natl Acad Sci USA. 2012; 109: 13668-13673. doi: 10.1073/pnas.1200872109
28. Huang H, Tan W, Wang CC, Leung LK. Bisphenol A induces corticotrophin-releasing hormone expression in the placental cells JEG-3. Reprod Toxicol. 2012; 34: 317-322. doi: 10.1016/j.reprotox.2012.04.008
29. Chung MK, Lau TS, Lui WT, et al. Expression of placental Toll-like receptors-3, -7 and -8 upon placental hepatitis B infection. Placenta. 2012; 33(9): A113.
30. Li L, Dou LX, Neilson JP, Leung PC, Wang CC. Adverse outcomes of Chinese medicines used for threatened miscarriage: a systematic review and meta-analysis. Hum Reprod Update. 2012; 18(5): 504-524. doi: 10.1093/humupd/dms025
31. Wang CC, Li L, Tang LY, Leung PC. Safety evaluation of commonly used Chinese medicines during pregnancy in mice. Hum Reprod. 2012; 27: 2488-2456. doi: 10.1093/humrep/des180
32. Li L, Dou LX, Leung PC, Wang CC. Chinese herbal medicines for threatened miscarriage: Review. Cochrane Database Syst Rev. 2012 ; 5: 1-85. doi: 10.1002/14651858.CD008510.pub2.
33. Leung TY, Wong KM, Wong HK, et al. A retrospective study of BACs-on-Beads (BoBs) technology for identification of chromosome abnormalities compared with QF-PCR and karyotyping in prenatal diagnosis. Am J Obstet Gynecol. 2012; 206 (1): S322 (725). doi: http://dx.doi.org/10.1016/j.ajog.2011.10.743
34. Li L, Tang LY, Man GCW, et al. Potential reproductive toxicity of Largehead Atractylodes Rhizome, the most commonly used Chinese medicine for threatened miscarriage. Hum Reprod. 2011; 26: 3280-3288. doi: 10.1093/humrep/der335
35. Xu H, Becker CM, Lui WT, et al. Green tea epigallocatchin-3-gallate inhibits angiogenesis and suppresses VEGFC/VEGFR2 expression and signaling in experimental endometriosis in vivo. Fertil Steril. 2011; 96: 1021-1028. doi: 10.1016/j.fertnstert.2011.07.008
36. Huang H, Li L, Wang Y, Tang LY, Wang CC, Leung LK. Genistein upregulates placental corticotropin-releasing hormone expression in lipopolysaccharide-sensitized mice. Placenta. 2011; 32(10): 757-762. doi: 10.1016/j.placenta.2011.07.082
37. Liu Ml, Li L, Leung PC, et al. Acupuncture for amblyopia in children. Cochrane Database of Systematic Reviews. 2011; 9: 1-11.
38. Wang CC, Borchert A, Ugun-Klusek A, et al. Monoamine oxidase A expression is vital for embryonic brain development by modulating developmental apoptosis. J Biol Chem. 2011; 286(32): 28322-28330. doi: 10.1074/jbc.M111.241422
39. Chan JYW, Lau CM, Ting TL, et al. Gestational and lactational transfer of melamine following gavage administration of a single dose to rats. Food Chem Toxicol. 2011; 49: 1544-1548. doi: 10.1016/j.fct.2011.03.046
40. Wang CC, Kazuki Y, Oshimura M, Ikeo K, Gojobori T. Gene dosage imbalance of human chromosome 21 in mouse embryonic stem cells differentiating to neurons. Gene. 2011; 481: 93-101. doi: 10.1016/j.gene.2011.04.003
41. Pong JCF, Chu CY, Li WY, et al. Association of hemopexin in tear film and conjunctival macrophages with vernal keratoconjunctivitis. Arch Ophthalmol. 2011; 129: 453-461. doi: 10.1001/archophthalmol.2011.41
42. Chan KYY, Xiang P, Zhou L, et al. Thrombopoietin protects against doxorubicin-induced cardiomyopathy: improves cardiac function and reversely alters specific signaling networks. Eur J Heart Fail . 2011; 13: 366-376. doi: 10.1093/eurjhf/hfr001
43. Huang L, Wong YP, Gu H, et al. Stem Cell-like Properties of human umbilical cord lining epithelial cells and the potential for epidermal reconstitution. Cytotherapy. 2011; 13: 145-155. doi: 10.3109/14653249.2010.509578
44. Lee KY, Fong BSP, Tsang KS, et al. Fetal stromal niches enhance human embryonic stem cell-derived hematopoietic differentiation and globin switch. Stem Cells Dev. 2011; 20: 31-38. doi: 10.1089/scd.2010.0196
45. Chu CY, Chu KO, Chan JYW, et al. Distribution of melamine in rat foetuses and neonates. Toxicol Lett . 2010; 199: 398-402. doi: 10.1016/j.toxlet.2010.10.004
46. Borchert A, Küttner G, Gießmann E, et al. Defining the immunoreactive epitope for the monoclonal anti-human glutathione peroxidase-4 antibody anti-hGPx4 Mab63-1. Immunol Lett. 2010; 133: 85-93. doi: 10.1016/j.imlet.2010.07.006
47. Khaw KS, Ngan Kee WD, Chu CY, et al. Effects of different inspired oxygen fractions on lipid peroxidation during general anaesthesia for elective Caesarean section. Br J Anaesth. 2010; 105: 355-360. doi: 10.1093/bja/aeq154
48. Pong JCF, Chu CY, Chu KO, et al. Identification of Hemopexin in Tear Film. Anal Biochem. 2010; 404(1): 82-85. doi: 10.1016/j.ab.2010.04.036
49. Chu KO, Chan KP, Wang CC, et al. Green tea catechins and their oxidative protection in the rat eye. J Arg Food Chem. 2010; 58(3):1523-1534. doi: 10.1021/jf9032602.
50. Wong HK, Wang CC, Pang CP, Choy KW. Identification of coding and non-coding RNA(s) specific for early human retina development. Mech Dev. 2009; 126 (Suppl.): S169 (09-P063).
51. Chu CY, Poon CW, Pong JCF, Pang CP, Wang CC. Human normal tear Proteome. Graef Arch Clin Exp. 2009; 247: 725-727. doi: 10.1007/s00417-008-0974-5
52. Ng LWC, SK Yip, Wong HK, et al. Adipose-derived stem cells from pregnant women show higher proliferation rate unrelated to estrogen. Human Reprod. 2009; 24(5): 1164-1170. doi: 10.1093/humrep/dep001
53. Xu H, Lui WT, Chu CY, Ng PS, Wang CC, Rogers MS. Anti-angiogenic effects of green tea catechin on an experimental endometriosis mouse model. Human Reprod. 2009; 24(3): 608-618. doi: 10.1093/humrep/den417
54. Kai Y, Wang CC, Kishigami S, Kazuki Y, et al. Enhanced apoptosis during early neuronal differentiation in mouse ES cells with autosomal imbalance. Cell Research. 2009; 19(2): 247-258. doi: 10.1038/cr.2008.305
55. Uehara S, Izumi Y, Kubo Y, et al. Specific expression of Gsta4 in mouse cochlear melanocytes: A novel role for hearing and melanocyte differentiation. Pigm Cell Melanoma Res. 2009 ; 22(1): 111-119. 00513.x doi: 10.1111/j.1755-148X.2008.00513.x
56. Law LW, Lau TK, Fung TY, Leung TY, Wang CC, Choy KW. De novo 16p13.11 microdeletion identified by high resolution array CGH in a fetus with increased nuchal translucency. Br J Obstet Gynaecol. 2009 ; 116(2): 339-343. doi: 10.1111/j.1471-0528.2008.01948.x
57. Choy KW, Wang CC, Yip SK, Chan SCC. High isoprostane level in cardinal ligament-derived fibroblasts and urine sample of women with uterine prolapse. Br J Obstet Gynaecol. 2009 ; 116(1): 127-128. doi: 10.1111/j.1471-0528.2008.01806.x.
58. Khaw KS, Wang CC, Ngan Kee WD, et al. Supplementary oxygen for emergency Caesarean section under regional anaesrhesia. Br J Anaesth . 2009; 102(1): 90-96. doi: 10.1093/bja/aen321
59. Uehara S, Izumi Y, Kubo Y, et al. Analysis of a specific function of the mouse inner ear melanocytes essential for hearing acuity. Genes Genet Syst. 2008 ; 83(6): 485.
60. Choy KW, Liu YM, Chu CY, et al. High isoprostane level in cardinal ligament-derived fibroblasts and urine sample of women with uterine prolapse. Br J Obstet Gynaecol. 2008; 115: 1179-1183. doi: 10.1111/j.1471-0528.2008.01806.x
61. Chu KO, Wang CC, Pang CP, Rogers MS. Method to determine stability and recovery of carboprost and misoprostol in infusion preparations. J Chromat B. 2007; 857: 83-91. doi: 10.1016/j.jchromb.2007.07.016
62. Wang CC, Lui WT, Chu CY, Lau TK, Rogers MS. Dynamic changes of pattern recognition lectins during normal and preeclamptic pregnancy. Placenta. 2007; 28: A. 67(A7. 19).
63. Han YB, Feng HL, Cheung CK, Lam EPM, Wang CC, Haines CJ. Expression of a novel T-complex testis expressed 5(Tctex5) in mouse testis, epididymis and spermatozoa. Mol Reprod Dev. 2007; 74: 1132-1140. doi: 10.1002/mrd.209631.
64. Wang CC, Chu KO, Chong WS, et al. Tea epigallocatechin-3-gallate increased 8-isoprostane level and induced caudal regression in developing rat embryos. Free Radic Biol Med. 2007; 43: 519-527. doi: 10.1515/CLCM. 2007.233.
65. Lai WW, Choy KW, Chu KO, et al. Differential penetrance of ofloxacin and moxifloxacin in human aqueous and vitreous following topical administration. Am J Ophthal. 2007; 144: 315-318.
66. Wang CC, Lui WT, Chu CY, et al. Characterisation of pattern recognition lectins during normal pregnancy in mouse. Hum Reprod. 2007; 22( Suppl 1): i174(P-445).
67. Tang T, Wang CC, Wong YF, et al. Characterizing abberrantly expressed microRNAs in chromosome 7 in cervical carcinoma. Proc Am Assoc Can Res Ann Meeting. 2007; 48: 96.
68. Choy KW, Tang T, Wang CC, et al. Investigating the microRNA profile in cervical cancer. Proc Am Assoc Can Res Ann Meeting. 2007; 48: 706.
69. Chu KO, Ho TC, Chiang WY, Wang CC, Lam DSC, Pang CP. Measuring triamcinolone acetonide in aqueous humor by gas chromatography-electron-capture negative-ion mass spectrometry. J Chromat B. 2007; 847: 199-204. doi: 10.1016/j.jchromb.2006.10.014
70. Kurosaki H, Kazuki Y, Hiratsuka M, et al. A comparison study in the proteomic signatures of multipotent germline stem cells, embryonic stem cells, and germline stem cells. Biochem Biophys Res Commun. 2007; 353(2): 259-267. doi: 10.1016/j.bbrc.2006.12.025
71. Wang CC, Yim KW, Poon TCW, et al. Innate immune response by ficolin binding in apoptotic placenta is associated with the clinical syndrome of preeclampsia. Clin Chem. 2007; 53: 42-52. doi: 10.1373/clinchem.2007.074401
72. Chu KO, Wang CC, Chu CY, Choy KW, Pang CP, Rogers MS. Uptake and distribution of catechins in fetal organs following in utero exposure in rats. Hum Reprod. 2007; 22: 280-287. doi: 10.1093/humrep/del353
73. Ko CH, Li K, Ng PC, et al. Pro-oxidative effects of tea and polyphenols, epigallocatechin-3-gallate and epigallocatechin, on G6PD-defficient erythrocytes in vitro. Int J Mol Med. 2006; 18(5): 987-994. doi: 10.3892/ijmm.18.5.987
74. Leung TN, Choy KW, Chu CY, et al. Specific binding of ficolins to apoptotic trophoblasts in preeclampsia. Hypertens Pregnancy. 2006; 25(S1): 43, O50. doi: 10.1373/clinchem.2007.074401
75. Rogers MS, Wang CC, Li CY, Tam WH, Chu KO, Chu CY. Oxidative stress in mid-pregnancy as a predictor of gestational hypertension and pre-eclampsia. Hypertens Pregnancy. 2006; 25(S1): 76, P007. doi: 10.1111/j.1471-0528.2006.01026.x
76. Rogers MS, Wang CC, Tam WH, Li CY, Chu KO, Chu CY. Oxidative stress in mid-pregnancy as a predictor of gestational hypertension and pre-eclampsia. BJOG-Int J Obstet Gynaecol. 2006; 113: 1053-1059. doi: 10.1111/j.1471-0528.2006.01026.x
77. Borchert A, Wang CC, Ufer C, Schiebel H, Savaskan NE, Kuhn H. The role of phospholipids hydroperoxide glutathione peroxidase(GPx4) isoforms in murine embryogenesis. J Biol Chem. 2006; 281(28): 19655-19664. doi: 10.1074/jbc.M601195200
78. Chan KP, Chu KO, Lai WK, Choy KW, Wang CC, Pang CP. Determination of ofloxacin and moxiflozacin and their penetration in human aqueous and vitreous humor by using HPLC-fluorescence detection. Anal Biochem. 2006; 353: 30-36. doi: 10.1016/j.ab.2006.03.016
79. Chu KO, Wang CC, Chu CY, et al. Pharmacokinetic studies of green tea catechins in maternal plasma and fetuses in rats. J Pharm Sci. 2006; 95(6): 1372-1381. doi: 10.1002/jps.20594
80. Chu CY, Xiao X, Zhou XG, et al. Metabolomic and bioinformatics analyses in asphyxiated neonates. Clin Biochem. 2006; 39(3): 203-209. doi: 10.1016/j.clinbiochem.2006.01.006
81. Choy KW, Wang CC, Ogura A, et al. Molecular characterization of developmental gene in eyes: through data-mining on integrated transcriptome databases. Clin Biochem. 2006; 39(3): 224-230. doi: 10.1016/j.clinbiochem.2005.12.005
82. Choy KW, Wang CC, Ogura A, et al. Genomic annotation of 15, 809 ESTs identified from pooled early gestation human eyes. Physiol Genomics. 2006; 25(1): 9-15. doi: 0.1152/physiolgenomics.00121.2005
83. Xia WJ, Yang M, Fok TF, et al. Partial neuroprotective effect of pretreatment with tanshinone IIA on neonatal hypoxia-ischemia brain damage. Paed Res. 2005; 58: 784-790. doi: 10.1203/01.PDR.0000180550.99162.BC
84. Rogers MS, Wang CC, Lau TK, et al. Relationship between isoprostane concentrations, metabolic acidosis, and morbid neonatal outcome. Clin Chem. 2005; 51: 1271-1274. doi: 10.1373/clinchem.2004.047241
85. Wang CC, Chu KO, Lau TK, et al. Predictive and prognosis values of increased cord blood and neonatal urinary F2-isoprostanes in asphyxiated newborns. Clin Chem. 2005; 51(S6): A104, C-2.
86. Wang CC, Chu KO, Chong WS, et al. Embryotoxicity of green tea catechins during pregnancy. Clin Chem. 2005; 51(S6): A140, C-123.
87. Yim KW, Wang CC, Poon CW, Rogers MS, Lau TK, Leung TN. Identification of putative serum proteins associated with pre-eclampsia. Clin Chem. 2005; 51(S6): A89, B-125.
88. Wang CC, Hwang JS, Gojobori T, Ikeo K. New Implementation of microarray profiling by triple hybridization. Clin Chem. 2005; 51: A196-197, D-129.
89. Wang CC, Tang LY, Choy KW, et al. New transcription factors for early eye formation in mouse. Genes Genet Syst. 2005; 80: 427.
90. Liu BY, Wang CC, Lau TK, et al. Meconium stained liquor(MSL) during labour is associated with raised neonatal cord blood 8-iso-prostaglandin F2α concentration. Am J Obstet Gynecol . 2005; 192: 289-294. doi: 10.1016/j.ajog.2004.06.083
91. Kadota M, Nishigaki R, Wang CC, et al. Proteomic signatures and aberrations of mouse embryonic stem cells containing a single human chromosome 21 in neuronal differentiation: an in vitro model of Down syndrome. Neuroscience. 2005; 129: 325-335. doi: 10.1016/j.neuroscience.2004.06.081
92. Chu KO, Wang CC, Chu CY, Rogers MS, Choy KW, Pang CP. Determination of catechins and catechin gallates in tissues by liquid chromatography with coulometric array detection and selective solid phase extraction. J Chromat B. 2004; 810: 187-195. doi: 10.1016/j.jchromb.2004.07.031
93. Souza AMB, Wang CC, Chu CY, Briton Jones CM, Haines CJ, Rogers MS. In vitroexposure to carbon dioxide induces oxidative stress in human peritoneal mesothelial cells. Hum Reprod. 2004; 19: 1281-1286. doi: 10.1093/humrep/deh164
94. Wang CC, Chu CY, Chu KO, et al. Trolox-equivalent antioxidant capacity(TEAC) assay versus oxygen radical absorbance capacity(ORAC) assay in plasma. Clin Chem. 2004; 50: 952-954. doi: 10.1373/clinchem.2004.031526
95. Chu KO, Wang CC, Rogers MS, Choy KW, Pang CP. Determination of catechins and catechin gallates in biological fluids by liquid chromatography with coulometric array detection and solid-phase extraction. Anal Chim Acta. 2004; 510: 69-76. doi:10.1016/j.aca.2003.12.060.
96. Khaw KS, Ngan Kee WD, et al. Supplementary oxygen for elective caesarean section under spinal anaesthesia: useful in prolonged uterine incision-to-delivery interval? Br J Anaesth. 2004; 92: 518-522. doi: 10.1093/bja/aeh092
97. Wang CC, Kadota M, Nishigaki R, et al. Molecular hierarchy in neurons differentiated from mouse ES cells containing a single human chromosome 21. Biochem Biophy Res Commun. 2004; 314: 335-350. doi: 10.1016/j.bbrc.2003.12.091
98. Chu KO, Wang CC, Rogers MS, Choy KW, Kwok KH, Pang CP. HPLC determination of lignocaine and its metabolite xylidine in aqueous humor. Anal Letter. 2003; 36: 2669-2682.
99. Souza AMB, Wang CC, Chu CY, Lam PM, Rogers MS. The effect of intra-abdominal pressure on the generation of 8-iso prostaglandin F2 during laparoscopy in rabbits. Hum Reprod. 2003; 18: 2181-2188. doi: 10.1093/humrep/deg405
100. Chu KO, Wang CC, Rogers MS, Pang CP. Quantifying F2-isoprostanes in umbilical cord blood of newborn by gas chromatography-mass spectrometry. Anal Biochem. 2003; 316: 2-111-117. doi: 10.1016/S0003-2697(03)00043-5
101. Rogers MS, Yim SF, Li KC, Wang CC, Arumanayagam M. Polyamine oxidase and diamine oxidase activity in cervical mucus associated with premalignant changes in the uterine cervix. Free Radical Biol Med. 2002; 333: S175, 462. doi: http://dx.doi.org/10.1006/gyno.2001.6521
102. Souza AMB, Rogers MS, Wang CC, Yuen PM, Ng PS. Comparison of peritoneal oxidative stress during laparoscopy and laparotomy. J Am Assoc Gynecol Lap. 2002; 10: 65-74. doi: 10.1016/S1074-3804(05)60237-X
103. Chan LY, Chiu PY, Siu SSN, Wang CC, Lau TK. Diclofenac-induced embryotoxicity is associated with increased embryonic 8-iso prostaglandin F2α level in rat whole embryo culture. Reprod Toxicol. 2002; 16: 841-844. doi: 10.1016/S0890-6238(02)00047-3
104. Rogers MS, Yim SF, Li KC, Wang CC, Arumanayagam M. A comparison of the enzymes polyamine oxidase and diamine oxidase in the cervical secretions in cervical intra-epithelial neoplasia. Gynecol Oncology. 2002; 84: 383-387.
105. Khaw KS, Wang CC, Ngan Kee WD, Pang CP, Rogers MS. The effect of high-inspired oxygen fraction during elective Caesarean section under spinal anaesthesia on maternal and fetal oxygenation and lipid peroxidation. Br J Anaesthsia. 2002; 88: 18-23. doi: 10.1093/bja/88.1.18
106. Rogers MS, Murray HG, Wang CC, et al. Oxidative stress in the fetal lamb brain following intermittent umbilical cord occlusions: a path analysis. Br J Obstet Gynaecol. 2001; 108: 1283-1290. doi: 10.1111/j.1471-0528.2001.00297.x
107. Qin Y, Wang CC, Rogers MS, Kuehn H, Pang CP. Determinants of umbilical cord arterial isoprostane at birth. Br J Obstet Gynecol. 2000; 107: 973-981. doi: 10.1111/j.1471-0528.2000.tb10399.x
108. Qin Y, Wang CC, Lau TK, Rogers MS. Colour ultrasounography: a useful technique in the identification of nuchal cord entanglement during labour. Ultrasound Obstet Gynecol. 2000; 15: 413-417. doi: 10.1046/j.1469-0705.2000.00113.x
109. Rogers MS, Wang CC. A comparison of three ultrasound estimates of intrapartum oligohydramnios for prediction of fetal hypoxia-reperfusion injury. Early Human Development. 1999; 56: 117-126. doi: http://dx.doi.org/10.1016/S0378-3782(99)00043-2
110. Rogers MS, Mongellia JM, Tsang B, Wang CC. Fetal and maternal level of lipid peroxidation in term pregnancies. Acta Obstet Gynecol Scand. 1999; 78: 120-124. doi: 10.1034/j.1600-0412.1999.780209.x
111. Rogers MS, Mongelli JM, Tsang KH, Wang CC, Law KP. Lipid peroxidation in cordblood at birth: the effect of labour. Br J Obstet Gynaecol. 1998; 105; 739-744. doi: 10.1111/j.1471-0528.1998.tb10204.x
112. Mongelli JM, Wang CC, Wang W, Pang CCP, Rogers MS. Oxygen free radical activity in the second stage of labor. Acta Obstet Gynecol Scand. 1997; 76: 765-768. doi: 10.3109/00016349709024344
113. Wang CC, Rogers MS. Lipid peroxide in cord blood: a randomised sequential pairs study of prophylactic saline amnioinfusion for intrapartum oligohydramnios. Br J Obstet Gynecol. 1997; 104: 1145-1151.
114. Wang CC, Rogers MS. Lipid peroxide in cord blood: the effect of amniotic fluid volume during labour. Br J Obstet Gynecol. 1997; 104: 1140-1144.
115. Wang CC, Rogers MS. Lipid peroxidation in cord blood: the effects of umbilical nuchal cord. Br J Obstet Gynecol. 1997; 104: 251-255.
116. Rogers MS, Lau TK, Wang CC, Yu KM. Amnioinfusion for the prevention of meconium aspiration during labour. Aust NZ J Obstet Gynecol. 1996; 36: 407-410.