A Special Edition by

Nephrology – Open Journal (NPOJ)

Submissions deadline: March 30th, 2019 (Publication Free of charges)

Release Date: May 5th, 2019 (Accepted papers will be published online immediately).

Soundarapandian (Vijay) Vijayakumar, PhD

Department of Pediatrics
Senior Scientist at Stanford University
Adjunct Associate Research Scientist at Columbia University
USA
E-mail: svijay4@stanford.edu

Pavithra Vijayakumar

Yale Medical College
USA
E-mail: pavithra.vijayakumar@yale.edu

Introduction of Special Edition

Global Health Policy and Kidney Disease

The special edition on “Global Health Policy and Kidney Disease” is an initiative by the Nephrology Open Journal to highlight the present and future challenges in kidney diseases faced by the global health community.

As the world’s population ages, and rates of diabetes and obesity rise even in developing countries, the prevalence of chronic kidney disease markers has risen to 10-13% of the adult population, and kidney disease was the 13th leading cause of death in 2013. Kidney diseases contribute to the morbidity of other chronic diseases like diabetes and cardiovascular disease, and to the morbidity of infectious diseases like sepsis and influenza, further heightening the need for a more concerted worldwide effort to spread awareness and prevention. Unchecked, kidney disease often progresses to end stage renal disease, which necessitates high-cost dialysis or transplant procedures, or death and CKD remains one of the few growing causes of mortality, despite the development of effective clinical practice guidelines.

To tackle these problems, several research and resource gaps must be addressed. We need to be able to detect kidney disease earlier, and these tests need to be made accessible in resource-poor countries. More kidney specialists need to be trained, and general practitioners need to be made more aware of the ways in which they can help their patients manage their kidney disease. Dialysis and transplantation need to be distributed more equitably throughout the world.

New treatments that can better slow or stop the progression of disease need to be developed. And, surveillance of kidney disease around the world needs to improve, so we can monitor the progress we make as we continue to fight the growing burden of this disease. This special edition invites manuscripts from all disciplines that will contribute to our ability to address any of these needs.

 

Case Report

A Case Report of Carcinoid Tumor of the Kidney

Ahmed Anas Zaougui*, Somuah Tenkorang, Aboubakry Sow, Soufiane Mellas, Mohammed Fadl Tazi, Abdelhak Khallouk, Mohammed Jamal El Fassi, Jalal Eddine El Ammari and Moulay Hassan Farih

Provisional PDF1.94 MB1.94 MB


Mini Review

The Role of Primary Cilia in Autosomal Dominant Polycystic Disease Revisited

Alina Guseynova, Pavithra Vijayakumar and Soundarapandian Vijayakumar*

Provisional PDF724 KB724 KB

 

Dr. Soundarapandian Vijayakumar

(Guest Editor)

A Special Edition by

Nephrology – Open Journal (NPOJ)

Submissions deadline: March 30th, 2019

Release Date: May 5th, 2019 (Accepted papers will be published online immediately).

Soundarapandian (Vijay) Vijayakumar, PhD

Department of Pediatrics
Senior Scientist at Stanford University
Adjunct Associate Research Scientist at Columbia University
USA
E-mail: svijay4@stanford.edu

Pavithra Vijayakumar

Yale Medical College
USA
E-mail: pavithra.vijayakumar@yale.edu

Introduction of Special Edition

Current Trends in Chronic Kidney Disease and Acute Kidney Injury

The special edition on “Current Trends in Chronic Kidney Disease and Acute Kidney Injury” is an initiative by the Nephrology Open Journal to highlight the current advances in both basic and clinical research in this field.

Chronic Kidney Disease (CKD) is a general term for heterogeneous disorders affecting kidney structure and function, which have a significant impact on global public health. It is currently defined as ‘kidney damage or GFR <60 ml/minute/1.73 m2 for three months or more, irrespective of the cause’ and is a common disorder affecting up to 16% of the population worldwide. On the other hand, Acute Kidney Injury (AKI) is a syndrome that results in a sudden decrease in kidney function or kidney damage within a few hours or few days. It is common in patients who are in the hospital, especially in intensive care units. Some of the major causes of AKI include decreased blood flow to the kidneys due to any underlying factor (such as hypertension, a heart attack, or the use of NSAIDs), direct damage to the kidneys resulting from many factors including sepsis and glomerulonephritis, and blockage of the urinary tract bladder, prostate or cervical cancer, or kidney stones.

Current advances in CKD and AKI highlight our increasing understanding of the nuanced interaction of kidney with other organs. For example, recent clinical studies indicate that exposure to proton pump inhibitors, used by an estimated 15 million Americans, associates with increased risk of incident CKD, CKD progression, and end stage renal disease (ESRD). Similarly, the LEADER trial demonstrates that people who have type 2 diabetes and prior cardiovascular disease are at a higher risk of developing CKD. In this context, there are new discussions emerging on the use of Vitamin D treatment in CKD and AKI. In basic research, new approaches such CRISPR/Cas gene editing systems, pharmacogenomics and the use of miRNAs have the potential to accelerate our understanding of as well as offer therapeutic intervention for CKD and AKI. In terms of surgical approaches, there is renewed interest in nephron-sparing surgery versus radial nephrectomy.

This special edition invites manuscripts from all disciplines that will contribute to our basic understanding of various aspects of CKD and AKI including renal fibrosis, polycystic kidney disease (PKD) and glomerulonephritis as well as advances in clinical research and therapeutic interventions related to AKI and CKD.

 

Research

Study of Intradialytic Hypertension: A Single Centre Analysis

Paike Nilrohit B*, Bhange Nilesh R, Ukadgaonkar Ajeya N, Gadekar Kshitija G and Kulkarni Sudhir G

Provisional PDF580 KB580 KB

 

Dr. Soundarapandian Vijayakumar

(Guest Editor)