Presenting in her late twenties, this case report examines a G6P2 patient at 11-weeks gestation that was diagnosed with a blighted ovum, as well as the subsequent outcome and methods of additional management. A blighted ovum refers to a fertilized egg that does not develop, despite the formation of a gestational sac. The most common cause of a blighted ovum is of genetic origin. Trisomies account for most first trimester miscarriages, while consanguineous marriages result in recurrent miscarriages due to a blighted ovum. Additionally, a higher percentage of deoxyribonucleic acid (DNA) damage in sperm carries a higher rate of miscarriage. Nutritional factors that may lead to a blighted ovum include low-levels of copper, prostaglandin E2, and anti-oxidative enzymes. High body mass index (BMI), especially in women with a BMI≥30 kg/m2 has been shown to be linked to a blighted ovum. Globally, it has been shown that a blighted ovum is a serious adverse event related to vaccination against dengue fever.
Endometrial cancer is cancer of, or from, the endometrium of the uterus. According to the ACS, it is estimated that, in the United States, about 61,880 cases of cancers of the body of the uterus will be diagnosed in 2019 alone, while about 12,160 women will die from the disease. There are several types and classifications of endometrial cancer based on basic histological or clinical features, or a combination of both. Most of the current interventions have been focused on early detection especially in high-risk women. This is a review of the epidemiology and risk factors, public health actions, and latest interventions in the management of endometrial cancer in the United States.
Endometrial cancer; the United States; Review.