Recently Published Articles
  • 2019, October

    original research

    Sirtuin Inhibitor as a Novel Cell Cycle Checkpoint and Regulator of the TP53-MDM2 Pathway in Uveal MelanomaOpen Access

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    Abstract [+]

    Purpose

    The liver is the most common site of uveal melanoma (UM) metastasis with approximately 50% of UM patients being affected. With no proven therapies that mitigate metastases the mortality rate is 85% within the first year after detection of the liver disease. In this study, we provide a mechanistic understanding of the de-regulation of the TP53-MDM2 pathway in UM, which plays a central role in tumor biology.

    Methods

    We investigated the TP53-MDM2 signaling pathway in the microenvironment of liver metastases taken from both a murine orthotopic xenograft and post-mortem metastatic UM human liver. These findings were studied in-depth using both primary and metastatic UM cell lines treated with the MDM2 antagonist Nutlin-3a and the sirtuin inhibitor and transcriptional activator of TP53, Tenovin-6.

    Results

    De-regulation of the TP53-MDM2 signaling pathway is specific to the liver microenvironment, providing a survival mechanism for UM metastases. Tenovin-6, not Nutlin-3a, reduced UM cell survival by increasing the percentage of cell death and reducing the percentage of proliferating cells. Tenovin-6 increased acetylation of p53, reduced ubiquitination of the protein, and acted as a cell cycle regulator.

    Conclusion

    Our findings suggest that in patients with metastatic UM de-regulation of TP53-MDM2 signaling pathway promotes growth of the liver metastases and provides pre-clinical information on the potential of targeting of the TP53-MDM2 signaling pathway via Tenovin-6.

    Keywords

    Uveal melanoma; Ocular tumors; Nutlin-3a; Tenovin-6; TP53; MDM2.


  • 2019, October

    systematic review

    Complications Related to Implants Used in Anterior Bleb Forming Glaucoma Surgery: A Systematic Review of the LiteratureOpen Access

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    Abstract [+]

    Purpose

    To make an account of published implant-related complications (IRC) by a systematic review of the literature.

    Methods

    A systematic search of Pubmed and Scopus databases and Google Scholar engine was performed with selection criteria to detect papers on IRC. We excluded unrelated papers and reviewed selected ones. We considered papers that did not explicitly state about occurrence or not occurrence of IRC as non-IRC reporting. Main outcome measures were the number of papers reporting on complications, IRC, and types of IRC.

    Results

    After the search, selection, and addition, we studied 109 papers. Incidence of IRC was 4.5%, half required explantation. While 26 implant studies found IRCs (23%), 13 case reports on surgical complications, 8 (61.5%) of them reported IRC. Frequent complications were conjunctival erosion, blockage of the tube, migration to anterior chamber or damage to surrounding tissues.

    Conclusion

    Most papers did not report on IRC. Length or nature of studies may skew finding IRC. The incidence of IRC was 4.5%. Hard and sharp implants carry a greater risk of IRC and explantation.

    Keywords

    Implant-related complications (IRC); Glaucoma surgery; Anterior bleb forming.


  • 2019, September

    review

    Do You Still Use Topical Antibiotics after Intravitreal Injections?Open Access

    PDF382.28 KB 382.28 KB
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    Abstract [+]

    Nowadays intravitreal drug injection is the most frequent treatment for retinal diseases. Despite widely use endophthalmitis is already most feared complication of every intravitreal injection in each patient. In clinical setting topical antibiotics have been widely used as a precaution to prevent endophthalmitis however recent published evidence showed it to be unnecessary. Furthermore repeated use of topical antibiotics might give rise to antibiotic resistance in conjunctival flora and thus more aggressive endophthalmitis. Strict asepsis has been awarded as the main rule for endophthalmitis prophylaxis intravitreal injection.

    Keywords

    Intravitreal injection; Steroid; Anti-vascular endothelial growth factor (VEGF); Topical antibiotic; Enodphthalmitis; Antibiotic resistance.


About the Journal

The Ophthalmology Open Journal (OOJ) is an online open access journal that serves as a one-stop reference for Ophthalmology and all eye related topics and discussions.

The Ophthalmology is the branch of medicine that deals with the anatomy, physiology, and diseases of the eye. An ophthalmologist is a specialist in medical and surgical eye problems.

Openventio is dedicated to act as a complete reference point for all Ophthalmology professionals and students across the world.

Aims and Scope

The Ophthalmology Open Journal (OOJ) positioned itself as a medium for promoting better patient care, research, education in ophthalmology and various communities in the field of Ophthalmology.

OOJ covers a wide array of subjects such as:

  • Retinal disease
  • Cataract and refractive surgery
  • Cornea and external disease
  • Diabetic micro vascular complications
  • Glaucoma
  • Pediatric ophthalmology
  • Eye redness
  • Dry eyes
  • Visual disturbances
  • Watery eyes
  • Eye pain
  • Eyelid twitch

Openventio wants to encourage documentation among the ever growing medical community to ensure data gets recorded and passed on to new practitioners in the field of medicine.

Submissions for this Journal are accepted from all practitioners and students of Ophthalmology, from experts in the field to novices who are just starting to learn and understand Ophthalmology. Openventio  encourages all practitioners ,students and experts of Ophthalmology to share their research/ideas with the scientific community through its open journal OOJ.

The audience of OOJ includes doctors, nurses, research assistants, local community practitioners, manufacturers, and students of various universities and general communities from different parts of the world.

The journal welcomes all types of articles such as original research, review, case-report, mini-review, editorial, short-communication, book review, opinion, commentary, letter to the editor, conference proceedings, technical report, errata, illustrations etc. We accept all types of articles such as original research, review, case-report, mini-review, editorial, short-communication, book review, opinion, commentary, letter to the editor, conference proceedings, technical report, errata, illustrations etc for publication in this journal.

We are open to receive comments or any corrections from any potential scientists to improve the quality of our Journal. Any feedback on journal improvement is most welcome.