Pancreas - Open Journal (POJ)
Recently Published Issues
Happy Authors
"I have to thank the excellent team of Openventio Publication and the reviewers for helping me to design the article regarding EUS/FNA.B of pancreatic mass lesions. In this article I shared my experience in EUS findings on pancreatic mass lesions. Looking forward for further publications on Pancreatic lesions in this excellent journal."
"Thank you for your support! Your quality and professionalism are much appreciated. There are three things that impressed me the most. First, the editorial team is highly specialized and professional. We were a little sceptical going ahead with this considering "safety science" is very niche, not sure if it'll be as effective. But your team surpassed my expectations in every way possible. So, you are a very professional team. Second, the journal selection analysis was very detailed and well-explained. It really goes to show how professionally and extensively you're experienced in this. It was extremely helpful and we feel more confident about the submissions. Third, the publication speed was swift! This was really something I didn't expect, the speed was really impressive. Finally, a big thank you, again, for being so helpful, and we look forward to collaborating with you again."
"My sincere gratitude to the team of openventio publication and the reviewers for persistently guiding me through the process and helping make the article a relevant one for current scenario in management of traumatic pancreatic injury. Through this article, we've shared our experiences in management of traumatic pancreatic injury which hopefully will add light in management of such patients. Thank you so much for everything. Looking forward to having more interactions in the near future."
"We are very happy and excited to have published our article in Pancreas – Open Journal. The entire process went very smoothly with prompt responses from the editorial staff. Overall a great experience working with this journal."
Recently Published Articles
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How to Perform Endoscopic Ultrasound-Guided Fine Needle Aspiration/Biopsy of Pancreatic Lesions?
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379.06 KB Full-Text (HTML)
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Clinical Profile and Management of Chronic Pancreatitis in Tertiary Care Centre
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368.59 KB Full-Text (HTML)
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The Global Rise of Diabetes – Time to Think Seriously About Environmental Toxicants as Risk Factors for Development of the Disease
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548.81 KB Full-Text (HTML)
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Efficacy of Minimal Invasive Methods in Management of Traumatic Pancreatic Injury
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452.70 KB Full-Text (HTML)
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Worrisome Features for Intraductal Papillary Mucinous Neoplasm: Should We be Worried?
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322.45 KB Full-Text (HTML)
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PARP Inhibitors in Pancreatic Cancer: From Phase I to Plenary Session
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397.94 KB Full-Text (HTML)
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Why HALO 301 Failed and Implications for Treatment of Pancreatic Cancer
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365.50 KB Full-Text (HTML)
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The Evolving Field of Stereotactic Body Radiation Therapy in Pancreatic Cancer
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437.42 KB Full-Text (HTML)
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Loss of Pancreatic β-cell Secretory Function During Disease Progression in Type 2 Diabetes Mellitus – A Small Cross-Sectional Study
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517.99 KB Full-Text (HTML)
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Volume 2, Issue 1
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3.64 MB Full-Text (HTML)
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PD-1/PD-L1 Blockade: A New Promising Therapy for the Treatment of Pancreatic Cancer?
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316.71 KB Full-Text (HTML)
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Volume 1, Issue 1
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2.68 MB Full-Text (HTML)
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Nutritional Support of Patients with the Abdominal Compartment Syndrome during Severe Acute Pancreatitis
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360.35 KB Full-Text (HTML)
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Evaluation of the Best Power Setting of Laser Waves in Pancreatic Surgery: ECHO ND-YAG Laser Ablation on Bovine Pancreatic Tissue
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2.40 MB Full-Text (HTML)
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Ultrasound Ablation in Advanced Pancreatic Cancer Patients – What should be the Next Step?
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315.31 KB Full-Text (HTML)
About the Journal
Pancreas – Open Journal (POJ) is an online open access end to end source that encompasses all information, advancements pertaining to pancreatic research and latest techniques.
Pancreatic medicine deals with identifying, isolating and hence curing diseases such as pancreatitis, diabetes, pancreatic cancer, etc.
Openventio is dedicated to act as an open access portal to all medical professionals who seek a single source for descriptive studies and developments in this field.
Aims and Scope
Pancreas – Open Journal is a peer-reviewed journal that aims to be a complete and reliable source of discoveries and publications in the form of original articles, review articles, case reports, and product launches that affect this field.
POJ covers a wide array of subjects as given below
- Gallstones and pancreas
- Alcoholism and its effects on pancreas
- Pancreatic and associated β-cell dysfunction
- Pancreatic cancer
- Pancreatic surgery
- Pancreatic emergencies
- Pancreatic β-cell proliferation in diabetes and
obesity - Interventional endoscopic techniques and
diagnosis - Metastases
- Radiation therapy
- Exercise
Openventio aims to encourage documentation among the ever-growing medical community to ensure that the data is recorded and passed on to the future generations of researchers and practitioners.
Submissions for this journal are accepted from all practitioners and students of the pancreas, from experts and novices exploring this area of study.
The audience of POJ includes doctors, nurses, research assistants, local community practitioners, manufacturers, and students of various universities and general communities from different parts of the world.
The journal welcomes all types of articles such as original research, review, case-report, mini-review, editorial, short-communication, book review, opinion, commentary, letter to the editor, conference proceedings, technical report, errata, illustrations, etc.
We are open to receive comments and corrections from subject experts to improve the quality of our journal.
Article in press
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How to Perform Endoscopic Ultrasound-Guided Fine Needle Aspiration/Biopsy of Pancreatic Lesions?
Provisional PDF
379.06 KB Full-Text (HTML)
Abstract [+]
A endoscopic ultrasound-guided fine needle aspiration/biopsy (EUS-FNA/B) of pancreatic solid and cystic lesions is a modality, which huge numbers of articles has showed its high diagnostic accuracy. The degree of technical difficulty, size and type of needle, endoscopic technique, use of suction to aspirate tissue, use or not use of a stylet in the needle assembly, maneuvers to have high quality tissue, availability of an on-site cytopathologist, and, finally, end sonographer’s experience and skills who does the procedure have impact on the EUS-FNA results. Standard 19-G and 22-G fine-needle aspiration needles with or without high negative pressure have proven to be reliable in obtaining high-quality histologic samples in various indications. Twenty-five-gauge (25-gauge) needles provide better diagnostic yield when sampling pancreatic lesions compared with 22-G needles. The novel 19-G and 22-G ProCore™ needles have demonstrated a high yield in obtaining histologic samples, whereas 25-G. ProCore™ seems unsuitable for histology. A cytopathology service should be involved early in the planning process for establishing an EUS-FNA service. Data on the newly developed 20-G ProCore™, SharkCore® and Acquire® needles are limited, but appear very promising. Use of the stylet does not increase the yield of endoscopic ultrasonography-fine-needle aspiration and is more cumbersome to use. In perspective, endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) is expected to refine differential diagnostic capabilities, favor widespread EUS utilization, and pave the road to targeted therapies and monitoring of treatment response. Approximately 3 to 5 passes should be sufficient to obtain a diagnosis. We need further studies for assessment of the use of Suction, Capillary (“Slow-Pull”), Wet and Fanning techniques.
Keywords
Pancreatic mass; Endosonography; Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA); Tissue aquisition; Stylet; Diagnostic accuracy; Cytology; Endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB).
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Management of Refractory Pancreatic Fistula: A Review of Literature
Provisional PDF
375.13 KB Full-Text (HTML)
Abstract [+]
Background
Chronic non-healing or refractory pancreatic fistulae are rare complications of pancreatic surgery (pancreaticoduodenectomy, distal pancreatectomy) or pancreatitis.
Materials and Methods
We conducted a thorough literature search of electronic databases such as PubMed, Google Scholar, BioMed Central, and Cochrane Library using the keywords and medical subject headings (MeSH) terms “chronic pancreatic fistula”, “post-operative fistula”, “fistula management” and “refractory pancreatic fistula”. The purpose of this review is to evaluate the management options for refractory pancreatic fistula (PF).
Results
Literature reveals that refractory pancreatic fistulae have been managed by techniques like endoscopic ultrasound (EUS)-guided techniques like transmural puncture by clamping, puncture of the fistula tract, transmural placement of pigtail stent, and EUS-guided pancreaticogastrostomy. Other techniques are postoperative endoscopic pancreatic stent placement in Grade C pancreatic fistula, intestinal decompression catheter insertion into the jejunum, embedding fistulojejunostomy, and fistulojejunostomy.
Conclusion
In conclusion, embedding fistulojejunostomy, EUS-guided transmural puncture by clamping, and EUS-guided transmural placement of pigtail stent are effective techniques for the management of refractory pancreatic fistulae. Yet further studies in a larger population are recommended.
Keywords
Chronic pancreatic fistula; Pancreatectomy; Pancreaticoduodenectomy; Fistutolojejunostomy; Post-operative pancreatic fistula.
Current Issue
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Worrisome Features for Intraductal Papillary Mucinous Neoplasm: Should We be Worried?
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322.45 KB Full-Text (HTML)
Full-Text (HTML)
Abstract [+]
Although worrisome features represent an indication to perform endoscopic ultrasound study, recent studies have showed that these conditions are not strictly related to high risk of malignancy. Pancreatic resection for worrisome imaging features often demonstrates pathology consistent with low-grade dysplasia. Worrisome features should be considered as indicators of mostly
low-grade dysplasia. High-risk stigmata are more consistent for diagnosis of malignant lesions.
Keywords
Worrisome features; High-risk stigmata; Intraductal papillary mucinous neoplasm (IPMN); Pancreatic neoplasm; Pancreatic high-grade dysplasia; Pancreatic low-grade dysplasia.
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Efficacy of Minimal Invasive Methods in Management of Traumatic Pancreatic Injury
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452.70 KB Full-Text (HTML)
Full-Text (HTML)
Abstract [+]
Introduction
Isolated pancreatic injury is relatively uncommon due to its mostly retroperitoneal location. However, if present, it is associated with other visceral injuries and causes serious complications if expected management is delayed.
Cases
In this report we have discussed about the different minimal invasive management approaches in two cases of pancreatic injury. The first case had American Association for the Surgery of Trauma Organ Injury Scale (AAST-OIS) grade IV pancreatic injury with late presentation who underwent ultrasound-guided percutaneous drainage of pseudocyst with video assisted lavage of cavity, followed by endoscopic retrograde cholangiopancreatography (ERCP) guided pancreatic duct stenting. Second case had AAST-OIS grade II pancreatic injury which was managed with serial percutaneous drainage.
Conclusion
Management of pancreatic injury is complex. Evolving trend of minimal invasive techniques of management for selected patients with higher grade pancreatic injury is associated with better outcomes.
Keywords
Pancreatic injury; Minimal invasive; Serial drainage.
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The Global Rise of Diabetes – Time to Think Seriously About Environmental Toxicants as Risk Factors for Development of the Disease
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548.81 KB Full-Text (HTML)
Full-Text (HTML)
Abstract [+]
Introduction
It is now estimated that the number of people living with diabetes worldwide in 2045 will be approximately 783 million, rising much faster than the global population growth of about 20%. In addition to the traditional known host risk factors (life-style changes associated with urbanization, physical inactivity, obesity and aging), it is probably prudent to begin to give serious thought to exposure to environmental toxicants, either because of mere geographical location or because of human industrial activity, as possible significant contributors. This knowledge could raise awareness while prompting us to find new ways to protect people and the environment.
Keywords
Diabetes; Environmental toxicants; Dioxins; Arsenic; Cadmium.
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Clinical Profile and Management of Chronic Pancreatitis in Tertiary Care Centre
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368.59 KB Full-Text (HTML)
Full-Text (HTML)
Abstract [+]
Background
Constant inflammation and irreversible pancreatic tissue destruction are hallmarks of the disease of chronic pancreatitis (CP), which results in the decrease of both exocrine and endocrine function over time. It is a multifactorial disease, with a wide range of symptoms and geographic variation.
Aim
Aim of this study is to study clinical profile and management of CP with respect to demography, clinical findings, lab parameters, imaging investigations and management modalities.
Methods
A cross-sectional observational study was conducted which included the patients admitted to the tertiary care center presenting with the clinical diagnosis of CP. The study was conducted over a period of 2-years from November 2019 to October 2021. A total sample size of 71 patients was included.
Results
In the study, it was observed that the majority of patients were in the age group of 51-60-years (47.89%) followed by 41-50-years (21.12%) mean age ranges from 56.54±12.63-years. The majority of patients were male (76.06%) and females were 23.94%. The distribution of patients according to aetiology showed that the majority of patients had aetiology of alcoholism (43.66%) followed by idiopathic (29.57%) Gall/Biliary stones (21.12%) and post-operative (5.63%). Majority of patients presented with pain in the abdomen (85.92%). The distribution of patients according to ultrasound sonography test (USG) findings showed that majority of patients shows pancreatic calcification (54.93%) followed by pancreatic pseudocyst (32.39%) and gall stones (19.72%). The distribution of patients according to computed tomography (CT) findings showed that majority of patients shows pancreatic calcification (70.42%). In the present study, it was observed that majority of patients were managed conservatively (43.66%) followed by cystogastrostomy (18.31%) and cystojejunostomy (8.45%). Endoscopic retrograde cholangiopancreatography (ERCP) was done among 14 (19.72%) patients. Lateral pancreaticojejunostomy was done in 6 (8.45%) patients and pancreaticoduodenectomy (Classical Whipple’s) was done in 4 patients (5.63%). The distribution of patients according to pain relief by various management showed that majority of getting relief from pain by surgery (69.23%) followed by ERCP (35.71%) and the least by conservative/analgesics (6.45%).
Conclusion
Chronic pancreatitis is progressive inflammatory disease. Alcoholic pancreatitis being most common etiology. Pain is most common presenting symptom. CT scan abdomen most useful in confirming diagnosis in our set up. Pseudocyst being common complication seen. Surgery gives relief of pain in most of the cases. The key to a better outcome is making the right decisions in terms of diagnosis, patient selection for surgery, and surgical type.
Keywords
Chronic pancreatitis; Inflammation; Etiology.
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Tailored Endoscopic Approaches for Pancreatic Traumatic Injuries
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274.52 KB Full-Text (HTML)
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Abstract [+]
Pancreatic traumatic injuries should be managed by multidisciplinary approach. Standard redo surgery can be avoided or supported by innovative mininvasive approaches both endoscopically and/or radiologically. Pancreatic endotherapy has an increasing role in the management of pancreatic injuries. Understanding the pathophysiology of pancreatic leak is crucial to guide the treatment. Endoscopic treatment must be tailored on the type and site of pancreatic fistula to achieve the optimal clinical outcome: there is not a one-way standard treatment but the best treatment for different types of pancreatic injuries considering both retrograde and endoscopic ultrasound (EUS)-guided approaches.
Keywords
Pancreatic fistula; Pancreatic traumatic injury; Endoscopic retrograde cholangiopancreatography (ERCP).
