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  • 2020, May

    systematic review

    Optimizing Cardiovascular Outcome in Type 2 Diabetes Mellitus with Better Control of Diabetes Mellitus with Empigliflozin and Hypertension with Renin Angiotensin System Inhibitors and Manidipine Preferably of the DihydropyridonesOpen Access

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    Aim: Obesity is increasing globally by leaps and bounds and thus the incidence of type 2 diabetes mellitus (T2DM) along with it so much so that the term diabesity had to be coined. Earlier we had reviewed how to treat the both together and the role of empagliflozin to improve cardiovascular outcome trials (CVOT). Similarly T2DM and hypertension are pathophysiologically-related diseases which co-exist with a broader complex of metabolic diseases which co-exist possessing similar set of risk factors. Hence it is important to consider which antihypertensives are suitable that possess a positive effect on metabolic factors in cases of T2DM who require an antihypertensive.

    Method: A systematic review was carried out using the PubMed search engine with the MeSH terms: “T2DM”; “essential hypertension; “cardiovascular (CV)”; “Complications of diabetes mellitus (DM) and antihypertensive”; “Antihypertensive preferred in T2DM subjects”; “Renin-angiotensin–aldosterone system inhibitors”; “Angiotensin converting enzyme inhibitors (ACEi)”; “Angiotensin receptor blockers (ARBs)”; “Dihydropyridine calcium channel blocker”; “β2 blockers”; “Diuretics”.

    Discussion: Most diabetes mellitus (DM) subjects need a minimum of two antihypertensive drugs, combining a renin-angiotensinaldosterone system (RAS) inhibitor with a dihydropyridine calcium channel blocker seems to be the most indicated approach. But not all dihydropyridine calcium channel blockers have equivalent effects on metabolic parameters. Hence manidipine that causes positive effect on insulin resistance (IR) seems to be an effective option. We have reviewed how manidipine is superior to amlodipine with regards to improving IR, not seen with amlodipine, along with not causing excessive sympathetic nervous system (SNS) activation, pulse pressure and ankle edema or to much lesser extent than amlodipine. Therefore, manidipine needs to be the first addition to RAS inhibitors in case of DM’s having hypertension of the dihydropyridines calcium channel blockers. Further good blood pressure (BP) control been correlated with good CVs outcomes.

    Conclusion: A RAS inhibitor is the first line of choice of drugs in a subject with T2DM who needs to be treated with empagliflozin for better CVOT outcome, and when a 2nd drug has to be added it is manidipine that is preferred over amlodipine. Plant products are proving to be having a lot of beneficial effects in DM, obesity and hypertension. Thus need for developing agents from plants will prove to be more cost effective in these chronic diseases where compliance is difficult to achieve with the use of common antiDM drugs and antihypertensives with the cost factor along with their side effects.


    Type 2 diabetes mellitus (T2DM); Diabesity; Antihypertensives; Renin-angiotensin-aldosterone system (RAS) inhibitor; Dihydropyridines calcium channel blockers; Plant products.

  • 2019, November

    case study

    A Couple’s Personalized-Care Intervention for Weight-Loss and Diabetes based on DNA and Gut Biome Profiles: A Case StudyOpen Access

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    The global prevalence of obesity has reached epidemic proportions. Given the negative strain that obesity and associated chronic diseases, such as type 2 diabetes, put on the healthcare system and the economy, disease management has begun evolving to help individuals change their behaviors. Obesity is often difficult to treat and even harder to maintain. Past studies have failed to show weight loss maintenance over long periods after interventions. To overcome the complexity of obesity, a multifaceted precision care treatment approach should be adopted.


    The aim of this case study was to assess the health benefits and weight loss journey of a cohabiting Caucasian heterosexual married couple using the Digbi Health personalized obesity management program. A personalized integrative nutrition plan is created based on one’s genetic and gut microbiome obesity risk profile and incorporates daily digital tracking and lifestyle coaching. Never before has a program offered personalized data including genetic, gut microbiome and lifestyle coaching to help people understand the best plan to lose weight and keep it off long term.


    The male subject achieved a total change in weight loss of 15.94%, as well as a reduction in A1C and blood pressure levels and the female subject achieved a 13.65% change in weight loss over a period of four months. The couple have still been able to maintain their weight loss goals four months after completing the program, stating their individual and personalized approach gave them the tools long-term to maintain.


    A supportive environment for cohabiting couples following a personalized weight loss program based on their genetic and gut microbiome profile may help with weight loss and long-term maintenance.


    Diabetes; Gut microbiome; Obesity; Diet; Physical exercise; Overweight; Body mass index (BMI); Couples; Hypertension.

  • 2019, September

    original research

    Relationships between Sleep, Sedentary Behavior, and Physical Activity in Young AdultsOpen Access

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    While there are some studies on sleep and physical activity, little is known regarding the associations between sleep and sedentary behavior. This study investigated the associations between sleep, sedentary behavior, and physical activity among young adults.


    Cross-sectional data from 124 undergraduate students were included in the analysis (age=21±1 years). Both accelerometer-based and self-report assessments of sleep were included; physical activity and sedentary behavior were assessed by accelerometers. Participants were asked to fill out sleep questionnaires and wear accelerometers for 7 days. Pearson correlations, partial correlations, and analysis of covariance (ANCOVA) analyses were performed to investigate the relationships between sleep, sedentary behavior, and physical activity.


    After adjusting for age, gender, percent body fat, educational level, and monthly allowance, prolonged sedentary time was correlated with a shorter sleep onset latency (r=-0.19, p=0.04), shorter time in bed (r=-0.43, p<0.001), and shorter sleep duration (r=-0.38, p<0.001). Moderate-to-vigorous physical activity (MVPA) was positively correlated with sleep onset latency (r=0.43, p<0.001). Sedentary behavior and MVPA were not correlated with sleep quality or daytime sleepiness. After further categorizing sleep duration into three subgroups, individuals with ≤6 hours (p<0.001) of sleep spent more time being sedentary than did those with 6-7 hours (p<0.001) and ≥7 hours (p=0.007) of sleep. Individuals with 6-7 hours of sleep had a higher level of MVPA than did those with ≥7 hours of sleep.


    Improving the duration of sleep may be a viable approach to help reduce sedentary behavior among young adults. Future studies with longitudinal designs are needed to further investigate the directionality of these associations and their potential mediators and moderators.


    Accelerometer; Sleep; Sedentary; Physical activity.

  • 2019, August

    systematic review

    The Role of Genetics in the Pathophysiology of Obesity: A Systematic ReviewOpen Access

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    The obesity epidemic has been largely attributed to changes in lifestyle habits established over the past three decades. These changes are mainly attributed to excessive nutrition and decline in physical activity as well as additional factors such as reduced intestinal microbiota diversity, sleep duration, endocrine disruptors, and reduced variability of the ambient temperature. However, the obesogenic environment is not sufficient to determine the presence of obesity, it is necessary that the lifestyle becomes associated with a personal predisposition for the phenotype to emerge. In this article, we review the main forms of monogenic and syndromic obesity, as well as a historical summary of the search for the genes that add up to confer greater risk for the development of polygenic obesity.


    We carried out a PubMed search, along with ExcerptaMedica database (EMBASE)/Cochrane library, Web Sciences for the Medical Subject Headings (MeSH) terms “obesity’’ AND “genetics” for the past 5-years.


    We found a total of 14057 articles pertaining to obesity and genetics together of which we selected 92 articles for this review after getting articles after searching cross references.


    Studies with twins and adopted children show that 55 to 80% of the variation of body mass index (BMI) is attributed to genetic factors. According to the genetic criteria, obesity can be classified as A) Monogenic – when a mutated gene is responsible for the phenotype; B) Syndromic – when a set of specific symptoms are present and a small group of genes is involved; usually the term is used to describe obese patients with cognitive delay, dysmorphic features, organ-specific abnormalities, hyperphagia, and/or other signs of hypothalamic dysfunction; C) Polygenic – also called “common” obesity, present in up to 95% of cases. Many genes add up to give a greater risk to the individual, and if associated with some habits culminates in obesity. In spite of its great relevance, the search for the genes that raise the risk of obesity has not been easy. It is still a challenge for the scientific community to separate the genetic element from the environmental component in the etiology of this disease. Individuals more susceptible to excessive adiposity may carry risk variants in the genes that influence appetite control, the regulation of cellular machinery, lipid metabolism and adipogenesis, the energy expenditure, insulin signaling, and inflammation.


    Obesity; Genetics; Polygenic; Monogenic; Syndromic; Polymorphism.

About the Journal

Obesity Research – Open Journal (OROJ) is an online open journal which covers obesity and its controlling measures, epidemiological, translational and clinical studies.

Obesity is one of the world’s most prevalent health problems. Obesity or overweight is the abnormal accumulation of fat in the body, which increases health risks like diabetes, hypertension, heart problems, osteoarthritis, cancer, and many others. Obesity is the result of overeating in most cases, but other factors include genetic makeup, sedentary lifestyle, etc.

However, Openventio aims to widespread all the detailed matters related to dietary through its Open Journal to all the scientific community for its welfare and control.

Aims and Scope

Obesity Research – Open Journal (OROJ) is dedicated to the open dissemination and robust discussion in the area of obesity and its related fields. Obesity Research – Open Journal (OROJ) focuses on all the aspects of Obesity Research.

OROJ covers a wide array of subjects as given below

  • Diet in obesity, diet and obesity
  • Health risks associated with  obesity
  • Rapid weight loss
  • Metabolism enhancers
  • Exercise Therapy
  • Morbid obesity
  • Physical activity

Submissions for this journal are accepted from the very basic obesity studies to the latest advancements.

The contributors of OROJ includes dieticians, surgeons, physicians, plastic surgeons, clinicians, surgical investigators, practitioners, educators, nurse, students, and the general community.

The journal welcomes all types of articles such as original research, review, case-report, mini-review, editorial, short-communication, book-review, opinion, commentary, letter to the editor, conference proceedings, technical report, errata, illustrations, etc.

We are open to receive comments or any corrections from any potential scientists to improve the quality of our journal.