Skip to content
  • Facebook
  • Twitter
  • linkedin
  • Instagram
Open Access Publisher of Medical and Social Science Journals
Openventio Publishers
  • Home
  • About us
    • Vision/Mission
    • Open Access
    • Editorial Assessment and Peer Review Process
  • Journals
  • Editorial Guidelines
    • For Authors
    • For Editors
    • For Reviewers
    • For Readers
    • For Librarians
  • Submit Manuscript
  • Contact Us
  • More
    • Advertisement
    • Reprints
    • Privacy Policy
    • FAQs

Volume 6

2020-2021, December

Volume 6, Issue 1

[ Download PDF ]

Volume 5

December, 2019

Volume 5, Issue 1

[ Download PDF ]

Volume 4

December, 2018

Volume 4, Issue 1

[ Download PDF ]

Volume 3

December, 2017

Volume 3, Issue 1

[ Download PDF ]

Volume 2

August, 2016

Volume 2, Issue 1

[ Download PDF ]

Volume 1

June, 2015

Volume 1, Issue 1

[ Download PDF ]

October, 2015

Volume 1, Issue 2

[ Download PDF ]

April, 2016

Volume 1, Issue 3

[ Download PDF ]

×

Article in press

NOTE: The DOIs of the In-Press Articles will only function after the final publication of the articles and once they are uploaded to the Current Issues.
×

Current Issue

  • 2020, October

    observational study

    Accuracy of Bioimpedance Modalities for Fluid Assessment in Hemodialysis Patients: A Randomized Observational StudyOpen Access

    Jacob C. John*, Graham T. Gipson, Christopher D. King, Timothy E. Bunchman and Oliver Karam
    DOI: https://dx.doi.org/10.17140/NPOJ-6-124
    PDF507.74 KB 507.74 KB
    Full-Text (HTML)
    Full-Text (HTML)
    Abstract [+]

    Aim
    Fluid overload is a major contributor to mortality in critically ill patients but is difficult to estimate clinically. Bioimpedance has been used to estimate fluid volumes with three different methods of analysis:1. single-frequency; 2. multi-frequency; 3. bioimpedance spectroscopy. The aim of this study is to assess the accuracy of different types of bioimpedance analysis in detecting changes in fluid volumes.
    Methods
    Prospective observational study, in end-stage renal disease patients requiring dialysis, in a tertiary care center. During hemodialysis, we assessed the correlation between change in estimated total body water volumes, as measured by all three methods of bioimpedance, and fluid volumes removed, as measured by changes in body weight.
    Results
    Twenty-four pediatric and adult patients were included in the study (median age 42.4 years) with a total of 30 study assessments performed. There was a weak correlation between change in body weight and change in estimated total body water volumes (R=0.15, 0.41, and 0.38, respectively). In the Bland-Altman analysis, the mean biases along with their associated 95% confidence limits of agreement were -0.23 L (-4.1 to 3.5 L) for single-frequency; -1.1 L (-4.1 to 1.9 L) for multi-frequency; and -0.6 L (-6.1 to 4.8 L) for bioimpedance spectroscopy.
    Conclusion
    In this study of end-stage renal disease patients requiring dialysis, the accuracy of bioimpedance measurement to evaluate fluid changes was poor, regardless of bioimpedance modality.
    Keywords
    Body composition/physiology; Body fluid/physiology; Electric impedance; Extracellular fluid/metabolism; Renal dialysis.


  • 2021, February

    original research

    Treatment of Acute Antibody-Mediated Rejection in Children Post-Kidney Transplantation: A Single Center’s ExperienceOpen Access

    Issa Alhamoud, Ei Khin, Rong Huang, Lesli McConnell and Mouin G. Seikaly*
    DOI: https://dx.doi.org/10.17140/NPOJ-6-125
    PDF418.90 KB 418.90 KB
    Full-Text (HTML)
    Full-Text (HTML)
    Abstract [+]

    Introduction
    Acute antibody-mediated rejection (aAMR) can negatively impact renal allografts outcomes. To date, there has not been a consistent therapeutic approach to manage aAMR. The aim of the study is to evaluate the tolerance and efficacy of an institutional protocol of methylprednisolone, intravenous gamma globulin (IVIG), rituximab, and bortezomib used to treat aAMR in pediatric renal transplant recipients (pRTRs).
    Methods
    A retrospective chart review was performed on 10 pediatric renal transplant recipients (pRTRs) who were diagnosed with aAMR on a renal biopsy performed between January 2014 and November 2015.
    Results
    Over the study period, 9.5% of pRTRs had aAMR. Sixty percent of whom had concurrent acute cellular rejection (ACR). Renal allografts survival was 100% during the the first post-aAMR. At the time of diagnosis of aAMR, estimated glomerular filtration rate (eGFR) had decreased by 42% (mean at baseline eGFR=67.2±19.5 mL/min/1.73 m2 vs mean at aAMR eGFR=38.9±14.2 mL/min/1.73 m2; p=0.002). At 1-year post rejection, eGFR had increased by 26% as compared eGFR at the time of rejection (mean eGFR=49.0±13.2 mL/min/1.73 m2; p=0.006). Immuno-dominant donor-specific anti-HLA antibody titers (iDSAs) class I and class II decreased by 69% and 15% at 6-month follow-up visit. No serious opportunistic infections nor malignancy were reported in our subjects.
    Conclusion
    Our study suggests that our protocol improved kidney function with 100% graft survival at 1-year post aAMR episode. The percentage decline in iDSAs class I titers was more significant than class II. Furthermore, our treatment protocol was well-tolerated with no life threatening complications.
    Keywords
    Acute antibody-mediated rejection (aAMR); Intravenous gamma globulin (IVIG); Pediatric renal transplant recipients (pRTRs).


  • 2021, April

    editorial

    Living Well with Kidney Disease by Patient and Care-Partner Empowerment: Kidney Health for Everyone EverywhereOpen Access

    Kamyar Kalantar-Zadeh*, Philip Kam-Tao Li, Ekamol Tantisattamo, Latha Kumaraswami, Vassilios Liakopoulos, Siu-Fai Lui, Ifeoma Ulasi, Sharon Andreoli, Alessandro Balducci, Sophie Dupuis, Tess Harris, Anne Hradsky, Richard Knight, Sajay Kumar, Maggie Ng, Alice Poidevin, Gamal Saadi and Allison Tong
    DOI: https://dx.doi.org/10.17140/NPOJ-6-e012
    PDF424.44 KB 424.44 KB
    Full-Text (HTML)
    Full-Text (HTML)

×

Previous Issue

  • 2019, March

    mini review

    Burden, Access, and Disparities in Kidney DiseaseOpen Access

    Deidra C. Crews*, Aminu K. Bello, Gamal Saadi and for the World Kidney Day Steering Committee**
    DOI: https://dx.doi.org/10.17140/NPOJ-5-121
    PDF466.97 KB 466.97 KB
    Full-Text (HTML)

  • 2019, June

    original research

    Changes in Estimated Glomerular Filtration Rate, Biochemical and Hematological Profile of Workers in Spray Painting Industry: A Cross-Sectional StudyOpen Access

    Christopher E. Ekpenyong* and Nseobong N. Nkereuwem
    DOI: https://dx.doi.org/10.17140/NPOJ-5-122
    PDF480.31 KB 480.31 KB
    Full-Text (HTML)
    Abstract [+]

    Introduction

    There is a global increase in occupational exposure to solvents, some of which are suspected to cause acute or chronic toxic nephropathies in humans. However, limited studies have been done to evaluate the systemic effects of exposure to some of the commonly used solvents such as paints.

    Aim

    The aim of the present study was to assess the effect of chronic exposure to paint fumes on renal and hepatic functions of industrial spray painters. Methodology In this cross-sectional study, 49 occupationally exposed male industrial spray painters who had served for greater than 5 years were evaluated for changes in renal, hepatic and hematological indices using standard instruments and results were compared with levels in the unexposed (sex and age-matched) participants.

    Results

    Significant changes in markers of renal, hepatic and hematological functions were observed in the exposed compared with unexposed participants including significant decrease in estimated glomerular filtration rate (eGFR) and serum levels of potassium (K+) and chloride (Cl-), and significant increases in serum levels of creatinine (Cr), sodium (Na+), urea (Ur) and uric acid (UA) in the exposed compared to levels in the unexposed group. Abnormal serum levels of hepatic enzymes (AST, ALT and ALP) and hematological indices (PCV, total-RBC, nuetrophils, basophils, monocytes and lymphocytes) were also observed in the exposed compared to levels in the unexposed participants.

    Conclusion

    Prolonged exposure to paint fumes may be associated with a significant risk for hepato-renal dysfunction and hematotoxicity. Preventive measures should include limiting exposure and using antioxidant medications.

    Keywords

    Spray painting; Toxicity; Workers; Kidney; Liver; Blood cells.
    Abbreviations ALT: Alanine transaminase; ALP: Alkaline phosphatase; AST: Aspartate transaminase; eGFR: Estimated glomerular fitration rate; C-G: Cockroft-Gault; MDRD: Modification of diet in renal disease; Na+/K+/ATPase: Sodium potassium adenosine triphosphatase; PH: Hydrogen Concentration; PCV: Packed cell volume; RBC: Red blood cells; ROS: Reactive oxygen species; UA: Uric acid; Ur: Urea.


  • 2019, August

    review

    The Use of Single-Cell Transcriptomics’ to Detect Cellular Transition through Notch Signaling and Receptor Expression in Differentiated Kidney Collecting Tubule Cells in Adult Mice: A ReviewOpen Access

    Matthew A. Cornacchia*, Soroush Nomigolzar, Giovanni Charles, Himax Patel and Kenneth Luberice
    DOI: https://dx.doi.org/10.17140/NPOJ-5-123
    PDF361.62 KB 361.62 KB
    Full-Text (HTML)
    Abstract [+]

    Transcriptomics has allowed for a better understanding of disease, and the sequencing of individual genes is becoming a leading approach to discovering novel germ lines. A newly defined cell type, described as transitional cells, was characterized based on their expression of key marker genes that define principle cells (PC) and intercalated cells (IC). Gene expression patterns suggested that a Notch signaling pathway was activated during the transition from IC to PC. An experimental model studying the transition in an inducible transgenic mouse demonstrated that Notch signaling and receptor expression is sufficient to drive cell transition in differentiated adult kidney collecting tubule. The identification of novel cell lines allows for a more accurate diagnosis of kidney disease and precise staging of disease. Molecular profiling and precision therapy will continue to revolutionize the field of medicine and warrants further exploration.

    Keywords

    Transcriptomics; Kidney disease; Principle cell; Intercalated cell; Notch signaling; Gene sequencing.

    Abbreviations

    PC: Principle cell; IC: Intercalated cell, DNA: Deoxyribonucleic acid; RNA: Ribonucleic acid; mRNA: Messenger ribonucleic acid.


    • Home
    • Authors Instructions
    • Submit Manuscript
    • Contact Us
    • Editorial Panel
    • Article in press
    • Current issue
    • Previous issue
    • Archive
    • Archive

    Connect with us



    Editor-in-Chief

    Rujun Gong, MD, PhD


    Associate Professor of Medicine
    Division of Kidney Diseases and Hypertension
    Rhode Island Hospital
    Brown University School of Medicine
    Middle House Suite 301
    593 Eddy Street
    Providence, RI 02903, USA

    Associate Editors

    Soundarapandian (Vijay) Vijayakumar, PhD


    Assistant Professor
    Department of Pediatrics
    Adjunct Associate Research Scientist
    Columbia University
    New York, USA

    Department of Pediatrics
    Senior Scientist at Stanford University
    New York, USA

    E-mail: svijay4@stanford.edu

    Rudolf Fluckiger, PhD


    Instructor Harvard Medical School Boston
    Brigham & Womens Hospital
    Orthopaedic Research (Retired)
    Founder: NOVACULE, LLC
    2587 Albany Street, West Hartford
    CT 06117, USA

    Zhousheng Xiao, MD, PhD


    Associate Professor
    Department of Nephrology- Medicine
    University of Tennesse- Health Science Center
    19S Manassas Street, CRB362; Memphis
    TN 38103, USA

    Ying-Yong Zhao, PhD, MD


    Professor
    Department of Traditional Chinese Medicine
    The School of Life Sciences
    Northwest University
    No. 229 Taibai North Road
    Xian, Shaanxi 710069, China

    Our editorial team


    Advertisement

    About Openventio

    Openventio Publishers is licensed under a Creative Commons Attribution 4.0 International License.
    based on the work at www.openventio.org

    Quick Links
    • Open Access
    • Submit Manuscript
    • Authors Instructions
    • Journals
    • Editorial Guidelines
    • Contact Us
    • Reprints
    • FAQs
    • Advertisement
    Find Us

    Suite#B013, Nexus Business Center
    Block-B, Level 2, Road no. 3
    Film Nagar, Hyderabad
    Telangana State, India

    Openventio Publishers
    • Facebook
    • Twitter
    • linkedin
    • Instagram
    © 2014 - 2022 Openventio Publishers. All Rights Reserved.
    • Open Access
    • Submit Manuscript
    • Authors Instructions
    • Journals
    • Editorial Guidelines
    • Contact Us
    • Reprints
    • FAQs
    • Advertisement