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Liver Research – Open Journal (LROJ)
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Archive-lroj

Volume 2

December, 2017

Volume 2, Issue 1

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Volume 1

August, 2015

Volume 1, Issue 2

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May, 2015

Volume 1, Issue 1

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Article in press

  • 2018, September

    editorial

    Don’t Shun the Shunt: Surgical Portosystemic Shunts in the Era of TIPS and Liver TransplantationOpen Access

    Her-HsinTsai*
    DOI: http://dx.doi.org/10.17140/LROJ-3-e004
    Provisional PDF260.48 KB 260.48 KB
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  • 2020, May

    original research

    Correlation of 18F-Fluorodeoxyglucose Glucose Uptake by Liver Cancer and Transcriptional Regulation of the Warburg Effects in ATT-MYC Mouse Model of Liver CancerOpen Access

    Mahmoud Elalfy* and Juergen Borlak
    DOI: http://dx.doi.org/10.17140/LROJ-3-112
    Provisional PDF463.83 KB 463.83 KB
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    Abstract [+]

    Background

    It was previously reported that diethylnitrosamine (DEN) enhanced liver cancer progression in ATT-MYC mouse model of liver cancer. Radiogenomics is a new tool in advanced science technology that gives information on tumor biology, non-tumor surrounding tissue, the degree of tumor size and presence of necrosis of cells especially with joined micro computed tomography – positron emission tomographys (CT/PETs).

    Aim

    To evaluate the correlation of gene expression and non-invasive microPET information of the liver tumors at different points of the stage of growth.

    Methods

    Exon array expression of the liver of ATT-MYC mice treated with DEN or butylated hydroxytoluene (BHT) compared to control non-transgenic mice were analyzed by array track and the current data were also compared to microarray expression of liver tumor of ATT-MYC mice.

    Results

    The expression of genes responsible for glucose transport such as glut1, 3, 4, hk1, slc1a5, slc1a1, slc1a4, slc1a2, gp6c and gpc-1-3-4 were up-regulated significantly in DEN-treated transgenic mice immediately after end of treatment (p≤0.05), while glut2 (fold change 0.9503, p-value 0.4385) and hk2 (fold change 3.0589, p-value 0.0565) genes were increased not significantly immediately after end of treatment. Additionally, at 4.5-months of observation after the end of treatment slc1a5, slc38a2, glut1, glut4 and gpc3-4 genes had a significant fold change in liver tumor tissue in DEN treated mice when compared to BHT or control transgenic or non-transgenic one. While hk1, 2, slc5a1, slc1a4, glut2, glut3, g6pc and gpc-1 genes were increased non-significantly in the liver of treated mice when compared to control group at 4.5-months of observation after the end of treatment. Notably, c-myc, hif-1 and aldoa glycolytic genes were expressed significantly both time points of 4 and 8.5-months while ldhb, hk-2 and PKM2 were increased non-significantly in DEN treatment when compared to BHT/control non-transgenic animals.

    Conclusion

    There is a definitive correlation between genes responsible for glucose transport and 18F-Fluorodeoxyglucose (FDG) uptake in the early and advanced degree of liver carcinogenesis. This study of glucose pathway in Hepatocellular carcinoma (HCC) at different stages of early and advanced one is the potential for therapeutic anticancer therapy.

    Keywords

    18-FFluorodeoxyglucose (FDG); MicroPET; Exon array expression; Hepatocellular carcinoma (HCC); Att-myc transgenic mice; Diethylnitrosamine (DEN), Butylated hydroxytoluene (BHT); Glucose metabolism.


NOTE: The DOIs of the In-Press Articles will only function after the final publication of the articles and once they are uploaded to the Current Issues.
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Current Issue

  • 2015, September

    editorial

    Hepatitis C UpdateOpen Access

    Omar Massoud*
    DOI:
    PDF297.12 KB 297.12 KB
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  • 2016, July

    original research

    Comparisons between Portosystemic Shunting Modalities in Patients with Liver Cirrhosis and Portal HypertensionOpen Access

    Firuz Gafurovich Nazyrov, Castro-Benitez C, Andrey Vasilyevich Devyatov, Azam Khasanovich Babadjanov*, Umid Ravshanovich Salimov and Laziz Lappasovich Mardonov
    DOI:
    PDF1.48 MB 1.48 MB
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  • 2017, January

    mini review

    Iron and Copper Toxicity in Rat Liver: A Kinetic and Holistic OverviewOpen Access

    Rosario Musacco-Sebio, Christian Saporito-Magriñá, Juan M. Acosta, Alberto Boveris and Marisa G. Repetto*
    DOI:
    PDF775.76 KB 775.76 KB
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  • 2017, May

    short communication

    Pediatric Acute Liver Failure: Current PerspectivesOpen Access

    José Colleti Jr., Rafael Teixeira Azevedo and Werther Brunow de Carvalho
    DOI:
    PDF342.40 KB 342.40 KB
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Previous Issue

  • 2015, May

    review

    The Prescribers’ Dilemma: Treatment of Hepatitis C Infection for Medicaid Insured Patients in United StatesOpen Access

    Hicham Khallafi*, Nina George and Kamran Qureshi
    DOI: http://dx.doi.org/10.17140/LROJ-1-105
    PDF402.27 KB 402.27 KB
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  • 2015, June

    review

    Non-Alcoholic Fatty Liver Disease: The Effect of Bile Acids and Farnesoid X Receptor Agonists on Pathophysiology and TreatmentOpen Access

    Quratulain Khalid, Ian Bailey and Vinood B. Patel*
    DOI: http://dx.doi.org/10.17140/LROJ-1-106
    PDF607.82 KB 607.82 KB
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  • 2015, June

    editorial

    Magnetic Resonance Elastography comes of AgeOpen Access

    Her-Hsin Tsai*
    DOI: http://dx.doi.org/10.17140/LROJ-1-e002
    PDF706.65 KB 706.65 KB
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  • 2015, July

    mini review

    Cardiovascular Disease and NASHOpen Access

    Erika Rabelo Forte de Siqueira*, Leila Maria Moreira Beltrao Pereira and Arun Jayant Sanyal
    DOI: http://dx.doi.org/10.17140/LROJ-1-107
    PDF345.21 KB 345.21 KB
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  • 2015, August

    case report

    Hepatic Myelopathy: Case Report and Review of the LiteratureOpen Access

    Huanquan Liao, Zhichao Yan, Wei Peng and Hua Hong*
    DOI: http://dx.doi.org/10.17140/LROJ-1-108
    PDF591.29 KB 591.29 KB
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    Editor-in-Chief

    Her-HsinTsai, MD, FRCP, FECG

    Consultant Physician and Gastroenterologist Hull and East Yorkshire NHS Hospital Trusts Hull Royal Infirmary Anlaby Rd, Hull East Riding of Yorkshire HU3 2JZ, UK

    Associate Editors

    Chandana B. Herath, PhD

    Senior Research Fellow Head of Hepatology Research Laboratory Department of Medicine The University of Melbourne Level 7, Lance Townsend Building Austin Health, 145 Studley Road Heidelberg, Victoria 3084, Australia  

    Zhenyuan Song, PhD

    Associate Professor Department of Kinesiology and Nutrition Department of Pathology College of Applied Health Sciences University of Illinois Medical Center 1919 W Taylor Street, RM 627 Chicago, IL 60612, USA

    Vinood B. Patel, PhD, PGCertHE, FHEA

    Senior Lecturer in Clinical Biochemistry Department of Biomedical Sciences Faculty of Science & Technology University of Westminster 115 New Cavendish Street London, W1W 6UW, UK

    Our editorial team


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