Internal Medicine – Open Journal (IMOJ)

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Recently Published Issues

December, 2018
Volume 2, Issue 1

April, 2017
Volume 1, Issue 1

Happy Authors

"I had a great experience in the process of reviewing my article and publication process. Thanks to the editor and all the members of the journal. The editorial assistant in particular was a great help."

Abdulhalim J. A. Kinsara, FRCP, FACC, FESC Assistant Professor - IMOJ

Recently Published Articles

2020, September

case report

Leg Ulcer in Patient with Sickle Cell Disease on Hydroxyurea

Jaya Manjunath and Fnu Nutan*
DOI: http://dx.doi.org/10.17140/IMOJ-4-114

PDF 310.85 KB

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2020, September

mini review

Sodium-Glucose Cotransporter-2 Inhibitors and Cardiovascular Disease: Lessons and the Future

Abdulhalim J. A. Kinsara*, Atif Al Qubbany and Wail Alkashkari
DOI: http://dx.doi.org/10.17140/IMOJ-4-113

PDF 274.70 KB

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2020, June

short communication

Proteinuria: A Guide to Diagnosis and Assessment

Sasha-Kay D’Aguilar and Amith Skandhan*
DOI: http://dx.doi.org/10.17140/IMOJ-4-112

PDF 508.71 KB

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2020, April

case report

Pseudo Metabolic Acidosis in the Setting of Hypertriglyceridemia: A Case Report

Atul Bali* and Roopa Naik
DOI: http://dx.doi.org/10.17140/IMOJ-4-111

PDF 213.87 KB

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2019, September

retrospective study

Morbidity and Mortality Associated with Development of Hypogammaglobulinemia after Rituximab

Hitoshi Hanamoto*, Aki Fujii, Mariko Fujita, Ko Fujimoto and Ryosuke Fujiwara
DOI: http://dx.doi.org/10.17140/IMOJ-3-110

PDF 394.56 KB

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2019, August

original research

Efficacy and Safety of Clarithromycin, Lenalidomide and Dexamethasone (Bird) Therapy for Japanese Patients with Relapsed or Refractory Multiple Myeloma

Hitoshi Hanamoto*, Aki Fujii, Mariko Fujita, Ko Fujimoto, Ryosuke Fujiwara and Kazuo Tsubaki
DOI: http://dx.doi.org/10.17140/IMOJ-3-109

PDF 415.88 KB

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2019, July

case report

Early Onset, But Late Diagnosis of a Rare Disease

Pamela Farah*, Pascale Daniel, Georges El Khoury, Rami El Rachkidi, and Aline Tohme
DOI: http://dx.doi.org/10.17140/IMOJ-3-108

PDF 313.08 KB

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2018, September

commentary

Philosophy of Internal Medicine – Osler and Hinohara-ism

Hiroshi Bando*
DOI: http://dx.doi.org/10.17140/IMOJ-2-107

PDF 269.32 KB

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2018, February

editorial

Levamisole in Medicine

Fnu Nutan*
DOI: http://dx.doi.org/10.17140/IMOJ-2-e001

PDF 273.79 KB

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2017, September

original research

Efficacy and Safety of Lenalidomide Prednisolone Combination Treatment for Japanese Elderly Multiple Myeloma Patients

Hitoshi Hanamoto, Aki Fujii, Mariko Fujita, Ryosuke Fujiwara, Katsuya Emoto, Keigo Sano, Shuji Minamoto and Hideo Yagi
DOI: http://dx.doi.org/10.17140/IMOJ-2-106

PDF 414.52 KB

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2017, April

case report

Anarchic Deposits: The Intersection of Calciphylaxis and Hemochromatosis, A Case Report

Angela Daher* and Fady G. Haddad
DOI: http://dx.doi.org/10.17140/IMOJ-1-105

PDF 691.13 KB

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2017, January

case report

Successful Third Hematopoietic Stem Cell Transplantation for Blast Crisis of Chronic Myeloid Leukemia After Two Times of Graft Failure

Keigo Sano, Aki Fujii, Ryosuke Fujiwara, Mariko Fujita, Shuji Minamoto, Keiko Yamazaki, Hideo Yagi, Kazuo Tsubaki and Hitoshi Hanamoto
DOI: http://dx.doi.org/10.17140/IMOJ-1-104

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2016, October

case report

Cerebellar Syndrome as a Presentation of Pulmonary Hypertension

Pablo Ruiz-Sada*, María-Jesús Iguzquiza-Pellejero, María-José Esquillor-Rodrigo and Lara Palacios-García
DOI: http://dx.doi.org/10.17140/IMOJ-1-103

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2016, September

original research

Evaluation of Cardio-Ankle Vascular Index and Influencing Factors in Natural Population of She Minority in China

Huan Liu, Yongqiang Hong, Xiuqin Wu, Xiaobin Zhang, Menghua Huang and Hongyu Wang*
DOI: http://dx.doi.org/10.17140/IMOJ-1-102

PDF 413.02 KB

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2016, September

case report

Successful Treatment of Autoimmune Hemolytic Anemia Concurrent With Gastric Cancer by Rituximab: A Case Report of Evans Syndrome

Hitoshi Hanamoto*, Keigo Sano, Ryousuke Fujiwara, Aki Fujii, Mariko Fujita, Keiko Yamazaki, Hideo Yagi and Kazuo Tsubaki
DOI: http://dx.doi.org/10.17140/IMOJ-1-101

PDF 1.03 MB

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About the Journal

Internal Medicine – Open Journal (IMOJ) is an online open access journal that serves as a one-stop reference for Internal Medicine or General Medicine.

Internal Medicine is a branch of medicine that deals with prevention, diagnosis, and treatment of adult diseases.

Openventio aims to act as a complete reference point for all Internal Medicine professionals and students across the world.

Aims and Scope

Internal Medicine – Open Journal is dedicated for promoting patient care, research, education in primary care, general medicine, and hospital medicine.

IMOJ covers a wide array of subjects as given below

Immunization
Obesity and weight management
Vascular biology
Internal medicine
Menopause
Cardiovascular disease
Stem cell research
Translational medicine

Openventio wants to encourage participation of ever growing medical community to ensure data gets recorded and passed on to new practitioners in the field of medicine.

Submissions for this Journal are accepted from all practitioners and students of Internal medicine, from experts in the field to novices who are just starting to learn and understand Internal medicine.

The contributors of IMOJ includes doctors, nurses, research assistants, local community practitioners, manufacturers and students of various universities and general communities from different parts of the world.

The journal welcomes all types of articles such as original research, review, case-report, mini-review, editorial, short-communication, book review, opinion, commentary, letter to the editor, conference proceedings, technical report, errata, illustrations, etc. This journal accepts all type of manuscripts providing knowledge on various aspects of internal medicine.

We are open to receive comments or any corrections from any potential scientists to improve the quality of our Journal. Any comments /feedback from any potential scientists to improve the journal quality would be appreciated.

Article in press

2020, April

case report

Pseudo Metabolic Acidosis in the Setting of Hypertriglyceridemia: A Case Report

Atul Bali* and Roopa Naik
DOI: http://dx.doi.org/10.17140/IMOJ-4-111

Provisional PDF 213.87 KB

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Abstract [+]

Low serum bicarbonate, with or without an elevated anion gap, can indicate metabolic acidosis. High anion gap metabolic acidosis is due to the unmeasured anions. Hypertriglyceridemia can also be associated with spuriously low serum bicarbonate levels due to lab interference. We present a 44-year-old woman who presented with anion gap metabolic acidosis in the presence of severe hypertriglyceridemia.

Keywords

Hypertriglyceridemia; Acid-base disorders; Low serum bicarbonate; Metabolic acidosis.

2020, June

short communication

Proteinuria: A Guide to Diagnosis and Assessment

Sasha-Kay D’Aguilar and Amith Skandhan*
DOI: http://dx.doi.org/10.17140/IMOJ-4-112

Provisional PDF 508.71 KB

Full-Text (HTML)

Abstract [+]

Proteinuria is a common incidental finding that physicians face in the inpatient and outpatient setting. Proteinuria may represent a benign pathology in asymptomatic patients, or it can be a sign of significant renal or systemic disease. The latter is usually associated with persistent proteinuria or other clinical findings such as renal failure. This article will focus on the mechanisms, causes and diagnostic approach of proteinuria. Proteinuria is a common incidental finding that physicians face in the inpatient and outpatient setting. Proteinuria may represent a benign pathology in asymptomatic patients, or it can be a sign of significant renal or systemic disease. The latter is usually associated with persistent proteinuria or other clinical findings such as renal failure. This article will focus on the mechanisms, causes and diagnostic approach of proteinuria.
Keywords
Proteinuria; Glomerular; Tubular; Nephritic; Nephrotic.

2020, September

mini review

Sodium-Glucose Cotransporter-2 Inhibitors and Cardiovascular Disease: Lessons and the Future

Abdulhalim J. A. Kinsara*, Atif Al Qubbany and Wail Alkashkari
DOI: http://dx.doi.org/10.17140/IMOJ-4-113

Provisional PDF 274.70 KB

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Abstract [+]

Diabetes mellitus (DM), an epidemic non-communicable disease, is associated with macro- and micro-vascular complications which may result in sudden cardiac death at a young age. Sodium-glucose cotransporter-2 inhibitors (SGLT2-I) emerged as a new therapeutic option for managing DM with cardiovascular complications as well as diabetic patients with multiple risk factors. Three drugs in this class significantly reduced cardiovascular mortality and heart failure events, in both type 2 diabetes mellitus and non-diabetic patients with a reduced ejection fraction, to prevent heart failure related hospitalisation. Evidence of kidney protection was another major advantage provided in more than one study. We reviewed recent SGLT2-I related literature and discuss the benefits beyond the cardiac system.
Keywords
Diabetes mellitus (DM); Cardiovascular disease; Sodium-glucose cotransporter-2 inhibitors (SGLT2-I); Renal protection.

2020, September

case report

Leg Ulcer in Patient with Sickle Cell Disease on Hydroxyurea

Jaya Manjunath and Fnu Nutan*
DOI: http://dx.doi.org/10.17140/IMOJ-4-114

Provisional PDF 310.85 KB

Full-Text (HTML)

Abstract [+]

Leg ulcers are a painful side-effect commonly seen in patients with long-term use of hydroxyurea. We describe an ulcer in a patient with sickle cell disease (SCD) with an 8-year history of hydroxyurea use. Wound care team used cadexomer-iodine topical
and collagenase to aid in healing. There are limited options for the treatment of these ulcers beside the cessation of hydroxyurea, a very effective drug in reducing painful sickle cell episodes. It is imperative to be aware of this complication to prevent expensive tests and further work up. Future study into alternative treatment of hydroxyurea-induced leg ulcers for sickle cell patients is necessary.
Keywords
Leg Ulcer; Sickle cell disease (SCD); Hydroxyurea.

NOTE: The DOIs of the In-Press Articles will only function after the final publication of the articles and once they are uploaded to the Current Issues.

Current Issue

2019, July

case report

Early Onset, But Late Diagnosis of a Rare Disease

Pamela Farah*, Pascale Daniel, Georges El Khoury, Rami El Rachkidi, and Aline Tohme
DOI:

PDF 313.08 KB

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Abstract [+]

One of the most common sphingolipidosis, Gaucher disease (GD) remains rare till date. A case report of a 56-year-old patient diagnosed with GD is presented herein. Her sister was known to have Gaucher disease. Her personal medical record consisted of splenectomy, anemia, recurrent infections, and bone lesions at a young age. Taking into consideration her personal and familial history, the clinical and paraclinical examinations, she was diagnosed with Gaucher disease which was confirmed with enzyme and gene testing. Upon introduction of specific enzyme replacement treatment for Gaucher patients,much evidence demonstrated the substantial improvement of hematological and visceral parameters. However, it has been observed that the bone tissue does not respond equally to the treatment.
Learning Points
• The physician should always investigate the splenomegaly of unknown etiology before deciding to do a splenectomy
• Bone lesions in Gaucher disease are sometimes irreversible, hence the importance of early diagnosis of this rare disease
Keywords
Gaucher disease; Bone lesion; Splenomeagly.
Acronyms
GD: Gaucher disease; Hb: Hemoglobin; MRI: Magnetic resonance imaging; ERT: Enzyme replacement therapy.

2019, August

original research

Efficacy and Safety of Clarithromycin, Lenalidomide and Dexamethasone (Bird) Therapy for Japanese Patients with Relapsed or Refractory Multiple Myeloma

Hitoshi Hanamoto*, Aki Fujii, Mariko Fujita, Ko Fujimoto, Ryosuke Fujiwara and Kazuo Tsubaki
DOI:

PDF 415.88 KB

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Full-Text (HTML)

Abstract [+]

Object

It is difficult for the elderly, those with complications, and those who live in remote areas to visit the hospital, and as a result, there are limits on the drugs they are able to use. It is therefore effective to prescribe such patients oral medications that have few adverse effects and in regimens that require few hospital visits. Clarithromycin can induce cell death by autophagy and it has a direct antitumor effect. There have been reports of the outcomes of Lenalidomide and Dexamethasone therapy with Clarithromycin which is administered orally and is safe on multiple myeloma. However, in Japan, there have been few studies. Here, we report on Clarithromycin, Lenalidomide and Dexamethasone therapy in our hospital.

Method

We analyzed 7 patients with relapsed refractory or refractory multiple myeloma who were treated at this hospital between January 2012 and December 2014. The Clarithromycin, Lenalidomide and Dexamethasone therapy were administered in a 28-day cycle as follows: Clarithromycin 400 mg/day for 28-days, Lenalidomide 15 mg/day for 21-days, and Dexamethasone was administered in a dose of 20 mg once per week. The response criteria used were standard International Myeloma Working Group (IMWG) Uniform Response Criteria. and adverse events were graded according to the national cancer institute-common terminology criteria for adverse events (NCI-CTCAE) Ver. 4. Statistical analysis was performed using Easy R (EZR).

Result

The response to Clarithromycin, Lenalidomide and Dexamethasone therapy were selective catalytic reduction (sCR) in 2 patients, CR in 1 patient, per rectum (PR) in 3 patients, and standard deviation (SD) in 1 patient. Response rates of PR or better were observed in 86% of the patients. Duration of response was median 316-days (range, 160-522-days). Median oculus sinister (OS) period was 1,907 days. Median OS following discontinuation of the study was 1,385 days. Hematological adverse events were G1-2 anemia in 3 patients and G3-4 anemia in 1 patient. G1-2 thrombocytopenia was observed in 1 patient and G3-4 thrombocytopenia was observed in 1 patient. Leukopenia of G1-2 was observed in 6 patients but G3 was not observed. Non-hematological adverse events were G1-2 liver disorder in 6 patients, G1-2 skin rash in 3 patients, and G1-2 constipation in 2 patients. G4 adverse events were fainting and duodenal ulcer in 1 patient each.

Conclusion

Clarithromycin, Lenalidomide and Dexamethasone can be safely and effectively administered in the relapsed refractory multiple myeloma

Keywords

Multiple myeloma; Bird; Clarithromycin, lethal dose (Ld).

2019, September

retrospective study

Morbidity and Mortality Associated with Development of Hypogammaglobulinemia after Rituximab

Hitoshi Hanamoto*, Aki Fujii, Mariko Fujita, Ko Fujimoto and Ryosuke Fujiwara
DOI:

PDF 394.56 KB

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Full-Text (HTML)

Abstract [+]

Objective

Low-levels of gamma globulin are associated with a risk of infection, and complications of hypogammaglobulinemia are often observed in hematologic malignancies. In chronic lymphocytic leukemia (CLL), IgG≤600 mg/dL is reportedly associated with higher risks of infection. The objective was to determine the risks of hypogammaglobulinemia and infection in malignant lymphomas for which rituximab that targets B-cells is used.

Methods

A retrospective analysis of data from medical records of patients with malignant lymphomas treated with rituximab-containing therapy at our hospital between April 2014 and March 2016 was performed to assess the risks of infections through an evaluation of IgG levels and hospitalizations for and deaths due to infections in patients hospitalized with infections during this period.

Results

From April 2014 to March 2016, 128 patients with malignant lymphomas received rituximab-containing therapy at our hospital, and 94 (61%) of these patients had IgG levels measured. These 94 patients were included in the analysis. The histological types were as follows: 30 had follicular lymphoma (FL), 17 had indolent non-Hodgkin’s lymphoma (iNHL), 42 had diffuse large B-cell lymphoma (DLBCL), and 5 had mantle cell lymphoma (MCL). The mean minimum immunoglobulin G (IgG) level in patients hospitalized for infection was 546 mg/dL and was 628 mg/dL in those not hospitalized (p=0.6). Although a significant difference was not observed, IgG levels tended to be low in hospitalized patients with infection. In addition, there were 4 patients with mean IgG levels that were 600 mg/dL or less in the 6-months immediately prior to hospitalization. Among these 2 died of infection.

Conclusion

Low-levels of gamma globulin are associated with a risk of mortality due to infections in malignant lymphomas.

Keywords

Hypogammaglobulinemia; Malignant lymphoma; Rituximab.

Abbreviations

CLL: Chronic lymphocytic leukemia; FL: Follicular lymphoma; iNHL: Indolent non-Hodgkin’s lymphoma; DLBCL: Diffuse large B-cell lymphoma; MCL: Mantle cell lymphoma; FN: Febrile neutropenia.

Editor-in-Chief

Chief Physician Department of vascular Medicine Peking University Shougang Hospital NO.9 Jinyuanzhuang Road Shijingshan District, 100144, Beijing China

Associate Editors

Director of Medicine Professor Department of Medicine Baruch Padeh Poria Medical Center affiliated to the Faculty of Medicine Bar-Ilan University Ramat Gan, 5290002, Israel

Recently Published Issues

December, 2018 Volume 2, Issue 1

April, 2017 Volume 1, Issue 1

Happy Authors

Recently Published Articles

Leg Ulcer in Patient with Sickle Cell Disease on Hydroxyurea

PDF 310.85 KB

Sodium-Glucose Cotransporter-2 Inhibitors and Cardiovascular Disease: Lessons and the Future

PDF 274.70 KB

Proteinuria: A Guide to Diagnosis and Assessment

PDF 508.71 KB

Pseudo Metabolic Acidosis in the Setting of Hypertriglyceridemia: A Case Report

PDF 213.87 KB

Morbidity and Mortality Associated with Development of Hypogammaglobulinemia after Rituximab

PDF 394.56 KB

Efficacy and Safety of Clarithromycin, Lenalidomide and Dexamethasone (Bird) Therapy for Japanese Patients with Relapsed or Refractory Multiple Myeloma

PDF 415.88 KB

Early Onset, But Late Diagnosis of a Rare Disease

PDF 313.08 KB

Philosophy of Internal Medicine – Osler and Hinohara-ism

PDF 269.32 KB

Levamisole in Medicine

PDF 273.79 KB

Efficacy and Safety of Lenalidomide Prednisolone Combination Treatment for Japanese Elderly Multiple Myeloma Patients

PDF 414.52 KB

Anarchic Deposits: The Intersection of Calciphylaxis and Hemochromatosis, A Case Report

PDF 691.13 KB

Successful Third Hematopoietic Stem Cell Transplantation for Blast Crisis of Chronic Myeloid Leukemia After Two Times of Graft Failure

PDF 1,018.52 KB

Cerebellar Syndrome as a Presentation of Pulmonary Hypertension

PDF 775.30 KB

Evaluation of Cardio-Ankle Vascular Index and Influencing Factors in Natural Population of She Minority in China

PDF 413.02 KB

Successful Treatment of Autoimmune Hemolytic Anemia Concurrent With Gastric Cancer by Rituximab: A Case Report of Evans Syndrome

PDF 1.03 MB

About the Journal

Aims and Scope

Article in press

Pseudo Metabolic Acidosis in the Setting of Hypertriglyceridemia: A Case Report

Provisional PDF 213.87 KB

Abstract [+]

Proteinuria: A Guide to Diagnosis and Assessment

Provisional PDF 508.71 KB

Abstract [+]

Sodium-Glucose Cotransporter-2 Inhibitors and Cardiovascular Disease: Lessons and the Future

Provisional PDF 274.70 KB

Abstract [+]

Leg Ulcer in Patient with Sickle Cell Disease on Hydroxyurea

Provisional PDF 310.85 KB

Abstract [+]

Current Issue

Early Onset, But Late Diagnosis of a Rare Disease

PDF 313.08 KB

Abstract [+]

Efficacy and Safety of Clarithromycin, Lenalidomide and Dexamethasone (Bird) Therapy for Japanese Patients with Relapsed or Refractory Multiple Myeloma

PDF 415.88 KB

Abstract [+]

Morbidity and Mortality Associated with Development of Hypogammaglobulinemia after Rituximab

PDF 394.56 KB

Abstract [+]

Previous Issue

Efficacy and Safety of Lenalidomide Prednisolone Combination Treatment for Japanese Elderly Multiple Myeloma Patients

PDF 414.52 KB

Levamisole in Medicine

PDF 273.79 KB

Philosophy of Internal Medicine – Osler and Hinohara-ism

PDF 269.32 KB

Connect with us

Editor-in-Chief

Hongyu Wang, MD

Associate Editors

Arnon Blum, MD

Our editorial team

December, 2018
Volume 2, Issue 1

April, 2017
Volume 1, Issue 1