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  • 2019, November

    original research

    Robot Assisted Comprehensive Surgical Staging for Endometrial Cancer: A Validation StudyOpen Access

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    Abstract [+]

    Objective

    The study sought to evaluate the historical surgical-pathological trends in Gynecologic Oncology Group (GOG) 33 in a cohort of patients who underwent robot-assisted staging of uterine carcinomas.

    Materials and Methods

    This is a retrospective study from June 2016 through December 2018 at Catholic Health Services Hospitals in Long Island (CHSLI), NY, USA. All patients underwent robotic surgical staging with hysterectomy, bilateral salpingo-oophorectomy, and pelvic and para-aortic lymphadenectomy. Fifty patients were included, and patients were separated into cohorts with endometrioid or non-endometrioid histology for analysis. Patients were staged using the International Federation of Gynecology and Obstetrics (FIGO) 2009 classification.

    Results

    For all patients undergoing surgical staging, the rate of pelvic and para-aortic nodal metastases occurred at 10% and 8%, respectively. Sixty percent of the grade 1 endometrioid tumors had less than 50% myometrial invasion. No patients had positive paraaortic lymph nodes in the absence of pelvic node involvement. High-risk histologies were associated with nodal disease thirteen percent of the time. A correlation between increasing depth of invasion and positive lymph nodes was demonstrated. Increasing grade of tumors was correlated with the frequency of nodal metastasis. Intraperitoneal spread was highly correlated to metastatic lymph nodes. Deep invasion was positively correlated with nodal disease.

    Conclusion

    The results of this study validate the trends previously known from GOG 33 in a population undergoing robot-assisted surgical staging for uterine carcinomas.

    Keywords

    Gynecologic Oncology Group (GOG) 33; Robotic; Surgery; Uterine cancer; Lymph nodes; Trends.


  • 2019, October

    original research

    A Study to Explore the Impact of Endometriosis in the United Kingdom: A Qualitative Content AnalysisOpen Access

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    Abstract [+]

    Objective

    To gain insight into the areas that impact women with endometriosis.

    Design

    A qualitative content analysis of an online survey.

    Setting

    Online questionnaire via Endometriosis UK.

    Population

    Women diagnosed with endometriosis of any age range.

    Methods

    Free-text online questionnaire through Endometriosis UK completed by women. Results were analysed using NVivo version 9, qualitative analysis software. The software creates links between common words (codes), and these links allow data to be placed in nodes (called themes) which are then developed into categories. Content analysis was used to understand this data.

    Main outcome measures

    Impact of endometriosis on women’s lives.

    Results

    In total, 1872 questionnaires were returned but not everyone was able to identify ten separate features that affected them. As such, 1872 women provided at least one area that affected them, 1800 provided two areas, 1770 provided three areas and 1600 provided four areas. The results show that the main areas of concern for these women were pain (53%), heavy menstrual bleeding (11%), low mood (8%) and the perceived lack of understanding displayed by other people (7%). Other important factors were fertility concerns, impact on employment, problems with the medical team and uncertainty. These then impacted on their daily life whereby some women felt “guilty” for not ‘being a normal mother’. A key term that resonated was that endometriosis is an “invisible disease”.

    Conclusion

    This analysis provides us with insight into the complex psycho-social factors that interact with bio-physical symptoms. Further research is required in sub-population groups such as teenagers and ethnic minority women to explore any differences in impact and how care can be guided accordingly.

    Keywords

    Endometriosis; Impact; Qualitative methods; Quantitative methods; Online survey.


  • 2019, June

    brief research report

    Compliance with Highly Active Antiretroviral Therapy (HAART) does not Prevent Human Papilloma Virus (HPV)- Related Cancers in Women Infected with Human Immunodeficiency Virus (HIV)Open Access

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    Abstract [+]

    Introduction
    Cancer is one of the leading causes of death in people with human immunodeficiency virus and acquired immune deficiency syndrome (HIV/AIDS), due to behavioral choices and overlapping risk factors.

    Aim
    The purpose of this report is to determine the long-term incidence of human papilloma virus (HPV)-associated cancer in women with pre-invasive cervical neoplasia, and compliance with medication and cancer screening recommendations.

    Methods
    HIV-infected women diagnosed with pre-invasive cervical neoplasia and an HPV-associated malignancy between 1995-2008 were identified. Data collected includes: demographics, HIV treatment/response, malignancy treatment/response, other healthcare utilization, use of health navigators, and compliance.

    Results
    Seventy-one subjects were identified with HIV infection, cervical dysplasia, and at least ten years’ follow-up. 17/71 (24%) were identified with an HPV-related malignancy. The mean age of those diagnosed with HPV-related malignancy was 39-years. Malignancies included: Cervix-9, Vulva-7, Anal-4, Vagina-3, Uretha/Bladder-2, Oropharyngeal-3. Eight also had in-situ neoplasms: Cervix-4, Vulva-3, Oropharyngeal-1. Four subjects had 3 separate malignancies, and two others had 2 malignancies. Compliance with HAART correlated strongly with immunocompetence, response to therapy, use of patient navigators, and survival. Sixty out of saventy one (84.5%) subjects underwent screening mammography, 57/71 (80.3%) underwent colonoscopy, and 67/71 (94.3%) underwent pap smear testing. Compliance with screening compared favorably with the general population, and overall survival was similar.

    Discussion and Conclusion
    The long-term incidence and mortality from cancer in women with HIV and cervical dysplasia appears to be comparable to that seen in the general population, with the possible exception of oropharyngeal cancers. Compliance with cancer screening recommendations appears to be higher than in the general population. This suggests that structured primary care programs for HIV-infected women are effective in prevention/early diagnosis of cancer. Standardized screening programs for oropharyngeal cancers should be considered in this population.

    Keywords
    Human immunodeficiency virus (HIV); Cancer; Human papilloma virus(HPV); Women; AIDS;
    Highly active anti-retroviral therapy (HAART).


About the Journal

The word “Gynecology” is originated from the Greek ancient “Gyne”, modern Greek “Gynaika” meaning Woman and “Logia” meaning study.

Due to the increase in reproductive problems in women, the need for advanced techniques and therapeutics has been also increased, which ultimately grew the demand for research and development in the field of gynecology.

The major risk factors of being prone to such problem include age, obesity, stress, hypertension, family history, HIV/AIDS, etc.

However, Openventio aims to widespread all the detailed matters through its Open Journal to all the scientific community for its welfare and control.

Aims and Scope

Gynecology and Obstetrics Research – Open Journal (GOROJ) is dedicated to the open dissemination and robust discussion in the area of women’s health such as gynecology and obstetrics research, education, clinical medicine, epidemiological studies, treatment, and critical care.

GOROJ covers a wide array of subjects as given below

  • Diabetes in pregnancy
  • Pain management in obstetrics
  • Placenta research
  • Obesity in pregnancy
  • Reproductive disorders
  • Women’s Health
  • Female infertility
  • Nausea and vomiting in pregnancy
  • Ovarian Cancer
  • Menstrual disorders
  • Smoking and alcohol consumption during
    pregnancy
  • Psychological aspects of gynecologic surgery

Submissions for this Journal are accepted from the very basic research to the novel advancements in Gynecology.

The audience of GOROJ includes gynecologists, obstetricians, pharmacologists, clinicians, researchers, physicians, surgeons, practitioners, educators, nurse, and students.

The journal welcomes a variety of article type such as original research, review, case-report, mini-review, editorial, short-communication, book-review, opinion, commentary, letter to the Editor, conference proceedings, technical report, errata, illustrations, etc.

We are open to receive comments or any corrections from any potential scientists to improve the quality of our Journal.