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  • 2019, June

    brief research report

    Compliance with Highly Active Antiretroviral Therapy (HAART) does not Prevent Human Papilloma Virus (HPV)- Related Cancers in Women Infected with Human Immunodeficiency Virus (HIV)Open Access

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    Abstract [+]

    Introduction
    Cancer is one of the leading causes of death in people with human immunodeficiency virus and acquired immune deficiency syndrome (HIV/AIDS), due to behavioral choices and overlapping risk factors.

    Aim
    The purpose of this report is to determine the long-term incidence of human papilloma virus (HPV)-associated cancer in women with pre-invasive cervical neoplasia, and compliance with medication and cancer screening recommendations.

    Methods
    HIV-infected women diagnosed with pre-invasive cervical neoplasia and an HPV-associated malignancy between 1995-2008 were identified. Data collected includes: demographics, HIV treatment/response, malignancy treatment/response, other healthcare utilization, use of health navigators, and compliance.

    Results
    Seventy-one subjects were identified with HIV infection, cervical dysplasia, and at least ten years’ follow-up. 17/71 (24%) were identified with an HPV-related malignancy. The mean age of those diagnosed with HPV-related malignancy was 39-years. Malignancies included: Cervix-9, Vulva-7, Anal-4, Vagina-3, Uretha/Bladder-2, Oropharyngeal-3. Eight also had in-situ neoplasms: Cervix-4, Vulva-3, Oropharyngeal-1. Four subjects had 3 separate malignancies, and two others had 2 malignancies. Compliance with HAART correlated strongly with immunocompetence, response to therapy, use of patient navigators, and survival. Sixty out of saventy one (84.5%) subjects underwent screening mammography, 57/71 (80.3%) underwent colonoscopy, and 67/71 (94.3%) underwent pap smear testing. Compliance with screening compared favorably with the general population, and overall survival was similar.

    Discussion and Conclusion
    The long-term incidence and mortality from cancer in women with HIV and cervical dysplasia appears to be comparable to that seen in the general population, with the possible exception of oropharyngeal cancers. Compliance with cancer screening recommendations appears to be higher than in the general population. This suggests that structured primary care programs for HIV-infected women are effective in prevention/early diagnosis of cancer. Standardized screening programs for oropharyngeal cancers should be considered in this population.

    Keywords
    Human immunodeficiency virus (HIV); Cancer; Human papilloma virus(HPV); Women; AIDS;
    Highly active anti-retroviral therapy (HAART).


About the Journal

The word “Gynecology” is originated from the Greek ancient “Gyne”, modern Greek “Gynaika” meaning Woman and “Logia” meaning study.

Due to the increase in reproductive problems in women, the need for advanced techniques and therapeutics has been also increased, which ultimately grew the demand for research and development in the field of gynecology.

The major risk factors of being prone to such problem include age, obesity, stress, hypertension, family history, HIV/AIDS, etc.

However, Openventio aims to widespread all the detailed matters through its Open Journal to all the scientific community for its welfare and control.

Aims and Scope

Gynecology and Obstetrics Research – Open Journal (GOROJ) is dedicated to the open dissemination and robust discussion in the area of women’s health such as gynecology and obstetrics research, education, clinical medicine, epidemiological studies, treatment, and critical care.

GOROJ covers a wide array of subjects as given below

  • Diabetes in pregnancy
  • Pain management in obstetrics
  • Placenta research
  • Obesity in pregnancy
  • Reproductive disorders
  • Women’s Health
  • Female infertility
  • Nausea and vomiting in pregnancy
  • Ovarian Cancer
  • Menstrual disorders
  • Smoking and alcohol consumption during
    pregnancy
  • Psychological aspects of gynecologic surgery

Submissions for this Journal are accepted from the very basic research to the novel advancements in Gynecology.

The audience of GOROJ includes gynecologists, obstetricians, pharmacologists, clinicians, researchers, physicians, surgeons, practitioners, educators, nurse, and students.

The journal welcomes a variety of article type such as original research, review, case-report, mini-review, editorial, short-communication, book-review, opinion, commentary, letter to the Editor, conference proceedings, technical report, errata, illustrations, etc.

We are open to receive comments or any corrections from any potential scientists to improve the quality of our Journal.