Volume 1, Issue 4

2015, July

review

Therapeutic and Chemopreventive Effects of Ursodeoxycholic Acid (UDCA): Potential Role in Patients with Barrett’s Esophagus

Xiaofang Huo*
DOI: http://dx.doi.org/10.17140/GOJ-1-115

PDF 379.78 KB

Full-Text (HTML)

2015, August

original research

Tenofovir Disoproxil Fumarate Treatment for Pediatric Patients with Perinatally Acquired Chronic Hepatitis B

Ricardo A. Arbizu*, Susan S. Baker, Rafal Kozielski and Robert D. Baker
DOI: http://dx.doi.org/10.17140/GOJ-1-116

PDF 539.11 KB

Full-Text (HTML)

2015, September

original research

Capsule Endoscopy: Indications, Findings and Complications among Patients with Suspected Small Bowel Lesions

Abdelmounem Eltayeib Abdo* and Dina Ali Mohammed
DOI: http://dx.doi.org/10.17140/GOJ-1-117

PDF 461.09 KB

Full-Text (HTML)

2015, September

editorial

A Double-Edged Sword and Swinging Pendulum: The Evolving Role of Percutaneous Endoscopic Gastrostomy Tubes in Patients with Advanced Dementia

Tawfik Khoury, Ayman Abu Rmeileh, Jonah Cohen and Meir Mizrahi*
DOI: http://dx.doi.org/10.17140/GOJ-1-e002

PDF 340.80 KB

Full-Text (HTML)

2015, October

original research

Effect of Chronic Proton Pump Inhibitor Use on Serum Magnesium Levels in Pediatric Patients

Amy Stanford and Riad Rahhal*
DOI: http://dx.doi.org/10.17140/GOJ-1-118

PDF 467.95 KB

Full-Text (HTML)

Article in press

2020, February

case report

Superior Mesenteric Artery and Nutcracker Syndromes in a Healthy 14-Year-Old Girl Requiring Surgical Intervention after Failed Conservative Management

David Wood, Andrew Fagbemi, Loveday Jago, Dalia Belsha, Nick Lansdale and Ahmed Kadir
DOI: http://dx.doi.org/10.17140/GOJ-5-132

Provisional PDF 360.10 KB

Full-Text (HTML)

Abstract [+]

This case report presents the diagnosis of superior mesenteric artery and nutcracker syndromes in a previously fit and well 14-year-old girl. Although these two entities usually occur in isolation, despite their related aetiology, our patient was a rare example of their occurrence together. In this case the duodenal compression of superior mesenteric artery syndrome caused intractable vomiting leading to weight loss, and her nutcracker syndrome caused severe left-sided abdominal pain and microscopic haematuria without renal compromise. Management of the superior mesenteric artery syndrome can be conservative by increasing the weight of the child which leads to improvement of retroperitoneal fat and hence the angle of the artery. The weight can be improved either by enteral feeds or parenteral nutrition. This conservative management initially helped but not in the long-term as the child started losing weight again. The next step in management is surgery (duodenojejunostomy – if the conservative management fails), which the child went through, remarkably improving their symptoms.

2021, June

review

Decision-Making in Diagnosis and Management of Extraintestinal Manifestations of Inflammatory Bowel Disease

Nicholas V. Costrini*
DOI: http://dx.doi.org/10.17140/GOJ-5-133

Provisional PDF 450.17 KB

Full-Text (HTML)

Abstract [+]

In the absence of certainty regarding the causes of both inflammatory bowel disease (IBD) and its extraintestinal manifestations (EIMs), there is necessarily ambiguity in both academic and clinical arenas concerning the diagnosis, classifications, and treatments of EIMs. While the “true” EIMs are considered extensions of the IBD gut pathogenesis with an immunologically mediated inflammatory consequence, other EIMs are considered to be complications of IBD itself or its treatment. A third group of IBD EIMs includes those disorders which seem to occur more often in IBD but for which an etiologic or pathophysiologic connection to IBD is highly theoretical. Patients with IBD and EIMs tend to have more severe, long-duration disease, and a reduced quality of life. EIMs presentation may or may not parallel IBD gut inflammatory activity. The clinical decision-making processes necessary for successfully managing simultaneously the gut component of IBD and its EIMs are presented. Based upon clinical experience and review of leading publications, the consensus of best practices, differential diagnoses for EIMs, and
current management programs are presented with enumeration of specific decisions and considerations required for successful management of EIMs. EIMs of inflammatory bowel disease reflect the immunopathologic common ground and hence the systemic nature of the IBD. A defined decision-making process is offered which includes consultations and attention to the differential diagnosis to avoid not uncommon mistakes in diagnosis. Management of all EIMs requires assessment of both the clinical and pathologic status
of the gut component of IBD combined with judicious selection of general and /or immunosuppression therapy for the EIMs.
Keywords
Ulcerative colitis; Crohn’s disease; Erythema nodosum; Pyoderma gangrenosum; Primary sclerosing cholangitis; Spondyloarthritis; Uveitis; Paradoxical dermatitis.

NOTE: The DOIs of the In-Press Articles will only function after the final publication of the articles and once they are uploaded to the Current Issues.

Current Issue

2019, May

letter to the editor

Endoscopic Treatment of Refractory Variceal Bleed

Shreyas Saligram*, Marina Roytman, Helen Wong and ThimmaiahTheethira
DOI: http://dx.doi.org/10.17140/GOJ-4-128

PDF 307.70 KB

Full-Text (HTML)

Full-Text (HTML)

2019, September

letter to the editor

Call Me Anything but Thoughtless or Misguided in IBD Management

Nicholas V. Costrini*
DOI: http://dx.doi.org/10.17140/GOJ-4-129

PDF 242.88 KB

Full-Text (HTML)

Full-Text (HTML)

2019, November

opinion

What IBD Physicians Can Learn from Major League Baseball Managers

Nicholas V. Costrini*
DOI: http://dx.doi.org/10.17140/GOJ-4-130

PDF 214.56 KB

Full-Text (HTML)

Full-Text (HTML)

2019, December

case report

The Importance of Enzyme Substitution Therapy in Early Pancreas Exocrines of Insufficiency

Biljana Petrovic*
DOI: http://dx.doi.org/10.17140/GOJ-4-131

PDF 257.68 KB

Full-Text (HTML)

Full-Text (HTML)

Abstract [+]

Introduction

Functional disorders of the digestive tract are a common occurrence in the doctor’s office. In addition to functional dyspepsia, 35% of dyspepsia are unresolved dyspepsia, which are a symptom of the early stage of pancreatic exocrine insufficiency.

Aim

Based on clinical experience, we can suspect and detect chronic pancreatic insufficiency at an early stage, which is the aim of this paper.

Method

To demonstrate the efficacy of enzyme replacement therapy in the early stage of pancreatic exocrine insufficiency using the case report of the patient.

Results

Results confirms significance and effectiveness of creon as an enzyme replacement therapy in the treatment of malabsorption and maldigestion.

Conclusion

Creon (pancreatin) showed great effect in the treatment of dyspepsia and anorexia nervosa, body mass index (BMI) for 30 days increased from 15.9 to 17.4, which leads us to the conclusion that unrecognized chronic pancreatic insufficiency can be expected in long-term dyspepsia.

Keywords

Chronic pancreatic insufficiency; Enzyme; Body mass index (BMI); Digestive tract.

Associate Editors

Assistant Professor Division of Digestive Diseases and Nutrition Department of Internal Medicine University of Kentucky Lexington, KY 40506, USA

Associate Professor Department of Surgery Institute of Molecular Medicine Trinity Centre for Health Sciences St James Hospital Dublin 8, Ireland

Department of of Interventional Gastroenterology Moffitt Cancer Center Department of Gastroenterology Kansas University Medical Center 235 Ward Parkway, Apt 307 Kansas City, MO-64112, USA

Volume 1, Issue 4

Therapeutic and Chemopreventive Effects of Ursodeoxycholic Acid (UDCA): Potential Role in Patients with Barrett’s Esophagus

PDF 379.78 KB

Tenofovir Disoproxil Fumarate Treatment for Pediatric Patients with Perinatally Acquired Chronic Hepatitis B

PDF 539.11 KB

Capsule Endoscopy: Indications, Findings and Complications among Patients with Suspected Small Bowel Lesions

PDF 461.09 KB

A Double-Edged Sword and Swinging Pendulum: The Evolving Role of Percutaneous Endoscopic Gastrostomy Tubes in Patients with Advanced Dementia

PDF 340.80 KB

Effect of Chronic Proton Pump Inhibitor Use on Serum Magnesium Levels in Pediatric Patients

PDF 467.95 KB

Article in press

Superior Mesenteric Artery and Nutcracker Syndromes in a Healthy 14-Year-Old Girl Requiring Surgical Intervention after Failed Conservative Management

Provisional PDF 360.10 KB

Abstract [+]

Decision-Making in Diagnosis and Management of Extraintestinal Manifestations of Inflammatory Bowel Disease

Provisional PDF 450.17 KB

Abstract [+]

Current Issue

Endoscopic Treatment of Refractory Variceal Bleed

PDF 307.70 KB

Call Me Anything but Thoughtless or Misguided in IBD Management

PDF 242.88 KB

What IBD Physicians Can Learn from Major League Baseball Managers

PDF 214.56 KB

The Importance of Enzyme Substitution Therapy in Early Pancreas Exocrines of Insufficiency

PDF 257.68 KB

Abstract [+]

Previous Issue

The Role of Pre-Assessment in Oesophageal Cancer Surgery

PDF 244.90 KB

Endoscopic Suturing of Esophageal Stent

PDF 408.12 KB

Microgenderome: An Important Variable for Developing Therapeutic Strategies?

PDF 279.33 KB

Connect with us

Associate Editors

Tatiana Goretsky (Zagranichnaya), PhD

Jacintha O. Sullivan, PhD

Shreyas Saligram, MD, MRCP

Our editorial team