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Prothrombin Complex Concentrates in Post-traumatic Hemorrhage: A Review
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Abstract [+]
Prothrombin complex concentrates (PCC) has long been used to reverse vitamin K antagonists (VKA)-induced coagulopathy rapidly and safely. However, its use in trauma-induced coagulopathy (TIC) in patients not using VKA drugs is yet to be elucidated. This article is a narrative review and analysis of the most recent literature to analyse consequences, and intended effects associated with this treatment modality in TIC. Utilization of PCC was addressed in the literature data found by searches of databases. The indications, efficacy and outcomes associated with the use of the product were reviewed in the articles. Some studies point out promising results with respect to PCC use to overcome the VKA-related coagulopathy in victims of trauma. PCC may be a viable option for resuscitation in emergency and critical care in the management of severe hemodynamic deterioration induced by trauma, despite contradictory findings in the literature.
Keywords
Blood coagulation factor; Trauma; Hemorrhagic shock; Exsanguinating hemorrhage.
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Editor-in-Chief
Chien-Chang Lee, MD, ScD
Director Department of Emergency Medicine National Taiwan University Hospital Yunlin Branch No 579, Sec 2, Yunlin Road, Douliou 640, Taiwan
Associate Editors
COL (RET) John McManus, MD, MBA, MCR, FACEP, FAAEM
EMS Fellowship Director Professor Department of Emergency Medicine Georgia Regents University Augusta, Georgia Area USA
Imoigele P. Aisiku, MD, MSCR, MBA, FACCP
Assistant Professor Department of Emergency Medicine Harvard University Brigham and Women’s Hospital 75 Francis Street Boston, MA 02115, USA
Robert Jude Strony, DO, RDMS, RVT
Staff Physician Emergency Department Geisinger Medical Center 100 North Academy Avenue Danville, PA 17822, USA