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Recently Published Articles
  • 2020, March

    mini review

    Beyond Placebo: Alternative Options to the Randomized Control Trial Design in Rare Disease StudiesOpen Access

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    Abstract [+]

    Unique difficulties and challenges can arise for rare diseases and orphan disease indications within a clinical trial. Some of the challenges encountered by trials that are working on rare diseases can include recruitment and enrollment. One of the explanations for the challenges that are encountered in rare disease trials is because of the trial design of study, where the investigational product is being compared to the placebo. This review paper discusses the usage of placebo and when other options could be taken into consideration while creating the protocol, specifically with consideration to rare disease studies. It is essential for the investigators and those designing the protocol to consider alternative options from the standard randomized controlled trial. The aim of this paper is to review alternative trial design options. The trial designs discussed in this review paper include crossover trials, single arm studies and historical data, and n-of-1 trials.


    Recruitment; Enrollment; Placebo controlled; Clinical trials; Rare disease; Crossover trials; Single arm study;
    Historical data; n-of-1 trials.

  • 2019, October


    Remote Consent Clinical ResearchOpen Access

    PDF281.37 KB 281.37 KB
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    Abstract [+]

    Recruitment in clinical research trials can be challenging in trials that are time-sensitive and/or are rare disease and critical care trials. One of the hurdles for recruitment in these types of clinical trials is due to the consent process, and the need to have consent of the patient within a certain timeframe, or the patient unable to consent for themselves. This paper will discuss the usage of the utilization of remote consent options for these trials.


    Recruitment; e-consent; Remote consent; Clinical trials; Rare disease; Time-sensitive.

  • 2019, October

    case report

    Role of Bactiguard Infection Technology in Preventing Catheter-Associated Urinary Tract InfectionsOpen Access

    PDF351.27 KB 351.27 KB
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    Abstract [+]

    To study the role of bactiguard infection technology (BIP) in preventing Catheter-associated urinary tract infections. This study was conducted in a tertiary care centre in the Department of Plastic Surgery, JIPMER, Pondicherry, India in the month of August 2019. The study subject was a 55-year-old gentleman with Fournier’s gangrene and type 2 diabetes mellitus (DM). The Foley’s catheter with BIP technology was used and its role in preventing urinary tract infections (UTI) was studied over a period of 10-days. During the period of the catheter use in our subject, patient did not develop features of urinary tract infections. BIP technology is claimed to be effective in preventing Catheter-associated urinary tract infections but further studies in more individuals is required to validate the same.


    Bactiguard infection technology (BIP); Catheter associated urinary tract infection (CAUTI); Biofilm.

  • 2019, August

    original research

    Role of Sound Enhancer Device in TeleconsultationOpen Access

    PDF329.78 KB 329.78 KB
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    Abstract [+]


    To study the role of sound enhancer device in teleconsultation.


    This study was conducted in the plastic surgery department in a tertiary care centre in the month of May-June 2019. A sound enhancer device was used with mobile phone for videoconferencing as form of teleconsultation by plastic surgery trainees in operation theatre and outpatient department. At the end of the study feedbacks were taken from the trainees.


    It was found that on using the sound enhancer device, the sound quality improved and it was helpful in the teleconsultation sessions using videoconferencing.


    The use of sound enhancer is a simple, cost-effective, innovative method of using a simple technology to aid in utilisation of teleconsultation facilities in a very non-sophisticated way.


    Sound enhancer device; Teleconsultation; Telemedicine.

  • 2019, July

    mini review

    Latest Results from Immunotherapy Clinical Trials in Triple Negative Breast CancerOpen Access

    PDF469.61 KB 469.61 KB
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    Abstract [+]

    Cancer immunotherapy has evolved enormously in the recent years with better understanding of immune reactions, immune microenvironment and immunosurveillance. Breast cancer is characterized by large heterogeneity, a fact which rather complicated the development and the approval of novel therapeutic options in comparison to the majority of other solid tumors since each subtype has required a unique scientific approach and different targets and goals. Triple negative breast cancer (TNBC) is considered the most aggressive of the breast cancer subtypes with limited treatment options and worse outcome compared to others. This article summarizes some of the early clinical studies and the recently presented phase III clinical study of immunotherapy checkpoint inhibitors in this difficult setting.

    Keywords: Cancer; Immunotherapy; Triple negative breast cancer (TNBC); Breast cancer.

  • 2017, March

    original research

    Distribution and Conduct of Clinical Trials Involving Music Therapy: Registered Clinical Trials in the Lost 15 YearsOpen Access

    PDF491.29 KB 491.29 KB
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    Abstract [+]

    Objective: This study aimed to conduct an evaluation of music therapy clinical trials
    worldwide, to understand what trials have been conducted and to show the chronological
    changes. Additionally, we sought to clarify issues related to providing clinical trial registration
    Methods: We searched the International Clinical Trials Registry Platform (ICTRP) database for
    “music therapy,” and identified the disease target for each article found.
    Results: A total of 150 clinical trial studies were found in the ICTRP using the term “music
    therapy.” In these trials, music therapy was used for improvement of social functioning in
    schizophrenia and/or serious mental disorders, anxiety and depressive symptoms, and cancer
    symptoms. Twenty-five clinical trials were actively recruiting. Sixteen of the 25 trials were
    registered in the United States at ClinicalTrials.gov, of which 9 trials were conducted in the US.
    Seven trials were conducted in other countries such as Spain, Taiwan, and China.
    Conclusion: A search for music therapy clinical trials retrieved 150 trials from the ICTRP, and
    the number of clinical trial registrations has increased yearly. Music therapy is widely used in
    patients with various diseases, including Alzheimer’s disease, anxiety, and arthritic pain and
    has the potential to improve certain disease outcomes, but there is not enough evidence to
    substantiate its efficacy. It is important to enlighten researchers and pharmaceutical companies
    on the proper management of the quality of such clinical trial information, as this is an important

About the Journal

Clinical Trials and Practice – Open Journal will discuss all fields related to clinical research, practice and the trials that help achieve results in clinical research.

Clinical Trials and Practice are experiments done in clinical research. Clinical trials are research studies that explore the new way of screening, prevention, diagnosis, or treatment of a disease in human beings.

The main objective of Openventio is to maintain the information related to Clinical Trials and to bring information from all the authors and diverse sources in a uniform way through our well-designed open access domain.

Aims and Scope

Clinical Trials and Practice – Open Journal is designed to answer all open-ended questions about clinical trials from the inception of a particular research study to final product or treatment rollouts.

CTPOJ covers a wide array of subjects as given below

  • Latest clinical trials and practice
  • Role of Investigators in clinical trials
  • Ethics in clinical research
  • Volunteers and research centers involved in clinical research
  • Medical product testing rules
  • Questionnaire ( case report form)
  • Antifungal medicines in clinical trials
  • ONSTEP hernia repair
  • Residual pain and chronic pain
  • Recurrence

Submissions for this Journal are accepted from fundamental research to detailed public health plans. Any manuscript that falls under the scope of clinical research and clinical trial is most welcome.

The audience of CTPOJ includes surgeons, physicians, pharmacists, registered nurses, pharmaceutical manufacturer’s adjunct healthcare professionals, housekeepers, policy makers, volunteers, practitioners, government watchdogs, students of various universities and general communities from different parts of the world.

The journal welcomes all types of articles such as original research, review, case-report, mini-review, editorial, short-communication, book review, opinion, commentary, letter to the editor, conference proceedings, technical report, errata, illustrations, etc.

We are open to receive comments or any corrections from any potential scientists to improve the quality of our journal.