Anjam Khan, PhD

Senior Lecturer
Microbial Pathogenicity Group
Institute for Cell and Molecular Biosciences &
School of Biomedical Sciences
The Medical School
University of Newcastle
Framlington Place, Newcastle, NE2 4HH, UK




• PhD in Molecular Biology, with Professor John Scaife FRSE, University of Edinburgh
• BSc Hons in Biochemistry, University of Manchester Institute of Science and Technology


• University of Cambridge, Postdoctoral Research Fellow
• Lecturer in Microbiology, University of Newcastle

Research Interest

His research interests include: Understand the biology of Salmonella and gain insights into the mechanisms by which it causes disease.

Scientific Activities


• Member, ICaMB Safety Committee


1. Karavolos MH, Winzer K, Williams P, Khan CM. Pathogen espionage: multiple bacterial adrenergic sensors eavesdrop on host communication systems. Molecular Microbiology. 2013; 87(3): 455-465. doi: 10.1111/mmi.12110
2. Bulmer DM, Kharraz L, Grant AJ, et al. The bacterial cytoskeleton modulates motility, type 3 secretion, and colonization in Salmonella. PLoS Pathogens. 2012; 8(1): e1002500. doi: 10.1371/journal.ppat.1002500
3. Karavolos MH, Bulmer D, Spencer H, et al. Salmonella Typhi sense host neuroendocrine stress hormones and release the toxin haemolysin E. EMBO Reports. 2011; 12(3): 252-258. doi: 10.1038/embor.2011.4
4. Khan CMA. The Dynamic Interactions between Salmonella and the Microbiota, within the Challenging Niche of the Gastrointestinal Tract. ISRN Microbiology. 2014; 2014: 23. doi: 10.1155/2014/846049
5. Doble AC, Bulmer DM, Kharraz L, Karavolos MH, Khan CMA. The function of the bacterial cytoskeleton in Salmonella pathogenesis. Virulence. 2012; 3(5): 446-449.
6. Nicholson A, Perry JD, James AL, et al. In vitro activity of S-(3,4-dichlorobenzyl)isothiourea hydrochloride and novel structurally related compounds against multidrug-resistant bacteria, including Pseudomonas aeruginosa and Burkholderia cepacia complex. International Journal of Antimicrobial Agents. 2012; 39(1): 27-32. doi: 10.1016/j.ijantimicag.2011.08.015
7. Staniewicz L, Donald AM, Stokes DJ, et al. The Application of STEM and In situ Controlled Dehydration to Bacterial Systems Using ESEM. Scanning. 2012; 34(4): 237-246. doi: 10.1002/sca.21000
8. Karavolos MH, Williams P, Khan CMA. Interkingdom crosstalk Host neuroendocrine stress hormones drive the hemolytic behavior of Salmonella typhi. Virulence. 2011; 2(4): 371-374. doi: 10.4161/viru.2.4.16810
9. Boonyom R, Karavolos MH, Bulmer DM, Khan CM. Salmonella pathogenicity island 1 (SPI-1) type III secretion of SopD involves N- and C-terminal signals and direct binding to the InvC ATPase. Microbiology. 2010; 156(6): 1805-1814. doi: 10.1099/mic.0.038117-0
10. Spencer H, Karavolos MH, Bulmer DM, et al. Genome-Wide Transposon Mutagenesis Identifies a Role for Host Neuroendocrine Stress Hormones in Regulating the Expression of Virulence Genes in Salmonella. Journal of Bacteriology. 2010; 192(3): 714-724. doi: 10.1128/JB.01329-09
11. Karavolos MH, Khan CMA. Multidirectional Chemical Signalling Between Mammalian Hosts, Resident Microbiota, and Invasive Pathogens: Neuroendocrine Hormone-Induced Changes in Bacterial Gene Expression. Microbial Endocrinology: The Microbiota-Gut-Brain Axis in Health and Disease. New York: Springer, 2014: 241-253.
12. Carnell SC, Perry JD, Khan CMA, De Soyza A. The bacterial cytoskeleton-A new antimicrobial target in cystic fibrosis pathogens? Thorax: British Thoracic Society Winter Meeting. Westminster, UK: BMJ Group, 2010. 13. Perrett CA, Karavolos MH, Humphrey S, et al. LuxS-Based Quorum sensing does not affect the ability of salmonella enterica serovar typhimurium to express the SPI-1 Type 3 secretion system, induce membrane ruffles, or invade epithelial cells. Journal of Bacteriology. 2009; 191(23): 7253-7259. doi: 10.1128/JB.00727-09
14. Ierano T, Silipo A, Sturiale L, et al. First structural characterization of Burkholderia vietnamiensis lipooligosaccharide from cystic fibrosis-associated lung transplantation strains. Glycobiology. 2009; 19(11): 1214-1223. doi: 10.1093/glycob/cwp112
15. Karavolos MH, Spencer H, Bulmer DM, et al. Adrenaline modulates the global transcriptional profile of Salmonella revealing a role in the antimicrobial peptide and oxidative stress resistance responses. BMC Genomics. 2008; 9(1): 458. doi: 10.1186/1471-2164-9-458
16. Karavolos MH, Bulmer DM, Winzer K, et al. LuxS affects flagellar phase variation independently of quorum sensing in Salmonella enterica serovar typhimurium. Journal of Bacteriology. 2008; 190(2): 769-771.
17. McKelvie ND, Khan SA, Karavolos MH, et al. Genetic detoxification of an aroA Salmonella enterica serovar Typhimurium vaccine strain does not compromise protection against virulent Salmonella and enhances the immune responses towards a protective malarial antigen. FEMS Immunology and Medical Microbiology. 2008; 52(2): 237-246.
18. Ieranò T, Silipo A, Sturiale L, et al. The structure and proinflammatory activity of the lipopolysaccharide from Burkholderia multivorans and the differences between clonal strains colonizing pre and posttransplanted lungs. Glycobiology. 2008; 18(11): 871-881. doi: 10.1093/glycob/cwn074
19. Liu W-T, Karavolos MH, Bulmer DM, et al. Role of the universal stress protein UspA of Salmonella in growth arrest, stress and virulence. Microbial Pathogenesis. 2007; 42(1): 2-10. doi: 10.1016/j.micpath.2006.09.002
20. Silipo A, Molinaro A, Ierano T, et al. The complete structure and pro-inflammatory activity of the lipooligosaccharide of the highly epidemic and virulent gram-negative bacterium Burkholderia cenocepacia ET-12 (strain J2315). Chemistry-A European Journal. 2007; 13(12): 3501-3511.
21. Karavolos MH, Roe AJ, Wilson M, et al. Erratum: Type III secretion of the Salmonella effector protein SopE is mediated via an N-terminal amino acid signal and not an mRNA sequence. Journal of Bacteriology. 2005; 187(5): 1559-1567.
22. Karavolos MH, Wilson M, Henderson J, Lee JJ, Khan CMA. Type III secretion of the Salmonella effector protein SopE is mediated via an N-terminal amino acid signal and not an mRNA sequence. Journal of Bacteriology. 2005; 187(5): 1559-1567. doi: 10.1128/JB.187.5.1559-1567.2005
23. Aldridge PD, Gray MA, Hirst BH, Khan CMA. Whos talking to whom? Epithelial-bacterial pathogen interactions. International Symposium on epithelial-bacterial pathogen interactions. Newcastle upon Tyne, UK: Molecular Microbiology: Wiley-Blackwell, 2004.
24. De Soyza A, Ellis CD, Khan CMA, Corris P, Demarco de Hormaeche R. Burkholderia cenocepacia lipopolysaccharide, lipid a and proinflammatory activity. American Journal of Respiratory and Critical Care Medicine. 2004; 170(1): 70-77.
25. Ellis CD, Lindner B, Khan CMA, Zahringer U, Demarco De Hormaeche R. The Neisseria gonorrhoeae lpxLII gene encodes for a late-functioning lauroyl acyl transferase, and a null mutation within the gene has a significant effect on the induction of acute inflammatory responses. Molecular Microbiology. 2001; 42(1): 167-181.
26. Heal KG, McConkey GA, Hormaeche CE, Hollingdale MR, Khan CMA, Taylor-Robinson AW. Expression of TetC fusion proteins from Salmonella in a gaseous environment that models conditions found in mammalian tissues. BioTechniques. 2000; 28(2): 228-232.
27. McNeill HV, Sinha KA, Hormaeche CE, Lee JJ, Khan CMA. Development of a nonantibiotic dominant marker for positively selecting expression plasmids in multivalent Salmonella vaccines. Applied and Environmental Microbiology. 2000; 66(3): 1216-1219.
28. Lee JJ, Sinha KA, Harrison JA, et al. Tetanus toxin fragment C expressed in live Salmonella vaccines enhances antibody responses to its fusion partner Schistosoma haematobium glutathione S-transferase. Infection and Immunity. 2000; 68(5): 2503-2512. doi: 10.1128/IAI.68.5.2503-2512.2000
29. Carnell SC, Biboy J, Cerardi G, et al. Pathogen associated molecular patterns in cystic fibrosis pathogens: analysis of peptidoglycan structure. British Thoracic Society Winter Meeting. London, UK: BMJ Publishing Group, 2013.
30. Macfarlane JG, Ruchaud-Sparagano MH, Scott JA, et al. Src kinase inhibition attenuates neutrophil degranulation without impairing bacterial killing: a Possible Therapeutic Strategy for Acute Lung Injury? British Thoracic Society Winter Meeting. London, UK: BMJ Publishing Group, 2013.
31. Carnell SC, Perry JD, Vollmer D, et al. Targeting the bacterial cytoskeleton of CF pathogens for antimicrobial development – a cautionary tale? British Thoracic Society Winter Meeting. London, UK: BMJ Publishing Group, 2013.