Andreas Eisenreich, PhD

Department of Clinical Pharmacology and Toxicology
Charité – University Medicine Berlin
Charitéplatz 1,10117 Berlin, Germany




• (2000-2006) Degree: Diploma, Biology Studies at the Humboldt-University Berlin
• (2006-2009) Promotion – Charité University Medicine Berlin, Charité Centrum 11, Department of Cardiology and Cardiovascular medicine


• (2009-2013) Charité University Medicine Berlin, Charité Centrum 11, Department of Cardiology and Cardiovascular medicine, Postdoctoral Fellow
• (2013-Present) Charité University Medicine Berlin, Charité Centrum 4 Department of Clinical Pharmacology and Toxicology, Postdoctoral Fellow

Research Interest

His research interest includes: Internal Medicine.

Scientific Activities


1. Chen XH, Koumoutsi A, Scholz R, et al. Comparative analysis of the complete genome sequence of the plant growth-promoting bacterium Bacillus amyloliquefaciens FZB42. Nat Biotechnol. 2007; 25: 1007-1014. doi: 10.1038/nbt1325
2. Eisenreich A, Celebi O, Goldin-Lang P, Schultheiss HP, Rauch U. Upregulation of tissue factor expression and thrombogenic activity in human aortic smooth muscle cells by irradiation, rapamycin and paclitaxel. Int Immunopharmacol. 2008; 8: 307-311. doi: 10.1016/j.intimp.2007.06.005
3. Tardos JG, Eisenreich A, Deikus G, et al. SR proteins ASF/SF2 and SRp55 participate in tissue factor biosynthesis in human monocytic cells. J Thromb Haemost. 2008; 6: 877-884. doi: 10.1111/j.1538-7836.2008.02946.x
4. Goldin-Lang P, Tran QV, Fichtner I, et al. Tissue factor expression pattern in human non-small cell lung cancer tissues indicate increased blood thrombogenicity and tumor metastasis. Oncol Rep. 2008; 20: 123-128. doi: 10.3892/or.20.1.123
5. Eisenreich A, Boltzen U, Poller W, Schultheiss HP, Rauch U. Effects of the Cdc2-like kinase-family and DNA topoisomerase I on the alternative splicing of eNOS in TNF-alpha-stimulated human endothelial cells. Biol Chem. 2008; 389: 1333-1338. doi: 10.1515/BC.2008.152
6. Eisenreich A, Bogdanov VY, Zakrzewicz A, et al. Cdc2-like Kinases and DNA Topoisomerase I Regulate Alternative Splicing of Tissue Factor in Human Endothelial Cells. Circ Res. 2009;104 :589-599. doi: 10.1161/CIRCRESAHA.108.183905.
7. Antoniak S, Boltzen U, Eisenreich A, et al. Regulation of cardiomyocyte full-length tissue factor expression and microparticle release under inflammatory conditions in vitro. J Thromb Haemost. 2009; 7: 871-878. doi: 10.1111/j.1538-7836.2009.03323.x
8. Eisenreich A, Malz R, Pepke W, et al. Role of the phosphatidylinositol 3-kinase/protein kinase B pathway in regulating alternative splicing of tissue factor mRNA in human endothelial cells. Circ J. 2009; 73: 1746-1752. doi: 10.1253/circj.CJ-99-0225
9. Eisenreich A, Rauch U. Regulation and differential role of the tissue factor isoforms in cardiovascular biology. Trends Cardiovasc Med. 2010;20:199-203. doi: 10.1016/j.tcm.2011.08.001.
10. Eisenreich A, Rauch U. PI3K Inhibitors in Cardiovascular Disease. Cardiovasc Ther. 2011; 29: 29-36. doi: 10.1111/j.1755-5922.2010.00206.x.
11. Rother M, Krohn S, Kania G, et al. Matricellular Signaling Molecule CCN1 Attenuates Experimental Autoimmune Myocarditis by Acting as a Novel Immune Cell Migration Modulator. Circulation. 2010; 122: 2688-2698. doi: 10.1161/CIRCULATIONAHA.110.945261
12. Ayral Y, Rauch U, Goldin-Lang P, et al. Prolonged clopidogrel application reduces tissue factor expression after percutaneous coronary intervention in the porcine model. Cardiovasc Revasc Med. 2011; 12: 47-55. doi: 10.1016/j.carrev.2009.12.001.
13. Fedorov O, Huber K, Eisenreich A, et al. Specific CLK Inhibitors from a Novel Chemotype for Regulation of Alternative Splicing. Chem Biol. 2011; 18: 67-76. doi: 10.1016/j.chembiol.2010.11.009.
14. Eisenreich A, Boltzen U, Malz R, Schultheiss HP, Rauch U. Overexpression of alternatively spliced Tissue Factor induces the pro-angiogenic properties of murine cardiomyocytic HL-1 cells. Circ J. 2011;75:1235-42. doi: 10.1253/circj.CJ-10-0783
15. Debdab M, Carrwaux F, Renault S, et al. Design, synthesis and biological evaluation of leucettines, a class of potent CLK and DYRK kinases inhibitors derived from the marine sponge leucettamine B. Modulation of alternative splicing. J Med Chem. 2011; 54: 4172-4186. doi: 10.1021/jm200274d
16. Bobbert P, Eisenreich A, Weithäuser A, Schultheiss HP, Rauch U. Leptin and resistin induce increased procoagulability in diabetes mellitus. Cytokine. 2011; 56: 332-337. doi: 10.1016/j.cyto.2011.05.019
17. Pepke W, Eisenreich A, Jaster M, et al. Bivalirudin inhibits peri-procedural platelet function and tissue factor expression of human smooth muscle cells. Cardiovasc Ther. 2011; doi: 10.1111/j.1755-5922.2011.00305
18. Boltzen U, Eisenreich A, Antoniak S, et al. Alternatively Spliced Tissue Factor and Full-length Tissue Factor Protect Cardiomyocytes against TNF-α-induced Apoptosis. J Mol Cell Cardiol. 2012;52:1056-65. doi: 10.1016/j.yjmcc.2012.01.015.
19. Löbel M, Bauer S, Meisel C, et al. CCN1: a novel inflammation-regulated biphasic immune cell migration modulator. Cell Mol Life Sci. 2012;69:3101-13. doi: 10.1007/s00018-012-0981-x
20. Eisenreich A, Leppert U. The Impact of Alternative Splicing on Cardiovascular Biology. Research Advances in Molecular Biology. 2013; 2:1.
21. Gauck S, Schultheiss HP, Rauch U, Eisenreich A. Modulation of the isoform expression of Cyr61 and integrin-αv in human microvascular endothelial cells. Cardiovasc Syst. 2013; 1: 8. doi: 10.7243/2052-4358-1-8
22. Eisenreich A, Zakrzewicz A, Huber K, et al. Regulation of pro-angiogenic tissue factor expression in hypoxia-induced human lung cancer cells. Oncol Rep. 2013;30:462-70. doi: 10.3892/or.2013.2413.
23. Eisenreich A. Regulation of vascular function on posttranscriptional level. Thrombosis. 2013; doi: 10.1155/2013/948765
24. Eisenreich A, Leppert U. The impact of microRNAs on the regulation of tissue factor biology. Trends Cardiovasc Med. 2014; 24:128-132. doi: 10.1016/j.tcm.2013.09.005
25. Leppert U, Eisenreich A. The role of tissue factor isoforms in cancer biology. Int J Cancer. 2014. doi: 10.1002/ijc.28959