Amit Modgil, PhD

Department of Neuroscience
School of Medicine
Tufts University
Boston, MA, USA

 

Biography

Dr. Modgil is a Postdoctoral fellow in the department of Neuroscience at Tufts university- School of medicine, Boston, MA. He has completed his doctoral training (PhD) in neurogenic hypertension from North Dakota state university, Fargo, ND. His doctoral research was focused on central blood pressure regulation and pathogenesis of hypertension to identify novel targets for the treatment of cardiovascular diseases. He has also worked at GSK, where he was part of the discovery and development of ion channel-targeting therapeutics team for the treatment of respiratory diseases. Dr. Modgil is a trained pharmacologist & electro physiologist with research experience in academia and industry. He has broad scientific knowledge in ion channel pharmacology and physiology. Utilizing electrophysiological techniques, his ongoing work is to examine the properties of recombinant and native extra synaptic GABAA receptors with special emphasis on α4 and δ subunits and their preferential targeting by endogenous and clinically relevant agents. His project is focused on fragile X syndrome in regards to altered activity of extra synaptic γ-amino butyric acid type A (GABAA) receptors that mediate tonic inhibition and impacts action potential firing frequency and are particularly sensitive to general anaesthetics and neurosteroids.

Research Interest

His research interests include: Extrasynaptic GABAA receptors mediate tonic inhibition and play an important role in regulating neuronal excitability. His research goals are focused on the development of novel therapeutic targets for the treatment of neurological disorders involving aberrant tonic inhibition. Extrasynaptic GABAA receptors may be the potential candidates for therapeutic treatment in range of neurological disorders such as fragile X mental retardation, γ-hydroxybutyric acid (GHB)-uria, stress, disorders associated with menstrual cycle and puberty, and idiopathic generalized and temporal lobe epilepsies. Utilizing electrophysiological techniques, his ongoing work is to examine the properties of recombinant and native extrasynaptic GABAA receptors with special emphasis on α4 and δ subunits and their preferential targeting by endogenous and clinically relevant agents. In particular, he is working on fragile X syndrome in regards to altered activity of extrasynaptic γ-aminobutyric acid type A (GABAA) receptors that mediate tonic inhibition and impacts action potential firing frequency and are particularly sensitive to general anaesthetics and neurosteroids.

Scientific Activities

HONORS AND AWARDS

• The honor society of Phi Kappa Phi: Member
• Oral presentation selected at 24th Neuropharmacology meeting at Arlington, VA, USA November 2014
• Awarded with 2011-2012 Darryle and Clare Schoepp Graduate Research Scholarship by the NDSU College Scholarship Recognition Committee
• Best Poster Presentation: 2nd prize at 42nd annual Pharmaceutics Graduate Student Research Meeting (PGSRM) 2010 in Columbus, Ohio
• Travel Award: AstraZeneca Travel ship award 2010 for American Association of Pharmaceutical Scientists (AAPS) 2010 national meeting at New Orleans
• Travel Award: The Joseph Buckley Fund from American Society for Pharmacology & Experimental Therapeutics (ASPET) to attend National meeting of EXPERIMENTAL BIOLOGY 2011 at Washington DC
• Travel Award: Non-Faculty Travel Award from Research, Creative Activities & Technology Transfer (RCATT) to attend National meeting of EXPERIMENTAL BIOLOGY 2011 at Washington DC
• Awarded Junior Research Scholarship by University Grant Commission (UGC) to pursue Masters Program in Medicinal Chemistry from Panjab University
• Awarded Masters Paramhansa Yogananda Scholarship in March 2004

MEMBERSHIP IN SCIENTIFIC AND PROFESSIONAL SOCIETIES

• American Physiological Society (APS) (2010-Present)
• American Association of Pharmaceutical Scientists (AAPS) (2007-Present)
• American Society for Pharmacology and Experimental Therapeutics (ASPET) (2010-Present)
• Society for Experimental Biology and Medicine (SEBM) (2010-Present)
• Member of Indian Pharmaceutical Association (IPA) (2003-2006)

Publications

Manuscripts

1. Abramian AM, Comenencia-Ortiz E, Modgil A, et al. Neurosteroids promote phosphorylation and membrane insertion of extrasynaptic GABAAreceptor. Proc Natl Acad Sci USA. 2014; 111(19): 7132-7137. doi: 10.1073/pnas.1403285111
2. Modgil A, O Rourke S, Sun C, et al. Angiotensin(1-7) Attenuates the Chronotropic Response to Angiotensin II via Stimulation of PTEN in the SHR Neurons. Am J Physiol Heart Circ Physiol. 2012; 302(5): H1116-H1122. doi: 10.1152/ajpheart.00832.2011
3. Modgil A, O Rourke S, Sun C. Apelin-13 Inhibits large-conductance Ca+2-activated K+ (BKca) channels in Vascular Smooth Muscle (VSM) cells via a PI3-kinase dependent Mechanism. PLOS ONE. 2013; 8(12): e83051. doi: 10.1371/journal.pone.0083051
4. Yao F, Modgil A, Zhang Q, et al. Pressor Effect of Apelin-13 in the Rostral Ventrolateral Medulla: Role of NAD(P)H Oxidase derived Superoxide. J Pharmacol Exp Ther. 2011; 336(2): 372-380. doi: 10.1124/jpet.110.174102
5. Sharma G, Modgil A, Sun C, Singh J. Grafting of cell-penetrating peptide to receptor-targeted liposomes improves their transfection efficiency and transport across blood-brain barrier model. J Pharm Sci. 2012; 101(7): 2468-2478. doi: 10.1002/jps.23152
6. Hevus I, Modgil A, Daniels J, et al. Invertible Micellar Polymer Assemblies for Delivery of Poorly Water-Soluble Drugs. Biomacromolecules. 2012; 13(8): 2537-2545. doi: 10.1021/bm3007924
7. Sharma G, Modgil A, Layek B, et al. Cell Penetrating Peptide Tethered Bi-ligand Liposomes for Delivery to Brain in vivo: Biodistribution and Transfection. Journal of controlled release. 2013; 167(1): 1-10. doi: 10.1016/j.jconrel.2013.01.016
8. Sharma G, Modgil A, Singh J, et al. Influence of Short-Chain Cell-Penetrating Peptides on Transport of Doxorubicin Encapsulating Receptor-Targeted Liposomes Across Brain Endothelial Barrier. Pharm Res. 2013 31(5): 1194-1209. doi: 10.1007/s11095-013-1242-x
9. Shukla P, Modgil A, O Rourke ST. Maternal Nutrient Restriction During Pregnancy Impairs an Endothelium-Derived Hyperpolarizing Factor-Like Pathway in Sheep Fetal Coronary Arteries. Am J Physiol Heart Circ Physiol. 2014; 307(2): H134-H142. doi: 10.1152/ajpheart.00595.2013