Amin F. Majdalawieh, PhD


Associate Professor of Biochemistry & Molecular Biology
Department of Biology
Chemistry and Environmental Sciences
American University of Sharjah
Sharjah, UAE

Biography

Dr. Amin Majdalawieh earned a PhD in Biochemistry and Molecular Biology from Dalhousie University, Halifax, Canada. He pursued a post-doctoral fellowship in the Department of Biochemistry & Molecular Biology at Dalhousie University, Halifax, Canada. He received several research awards. His main research interests include cardiovascular disease (atherosclerosis), macrophage cholesterol homeostasis, obesity, signal transduction, inflammation, natural products, and nutritional immunology, and cancer immunology.

Research Interest

His research interests includes Atherosclerosis, Obesity, Cancer, Macrophages, Inflammation, Cholesterol metabolism, Medicinal Chemistry, Natural Products & Herbal medicine, Nutritional immunology.

Scientific Activities

AWARDS AND SCHOLARSHIPS

06/2012 – Faculty Research Grant (FRGI) Award (group of 8 AUS faculty), American University of Sharjah (AUS)
06/2011 – Faculty Research Grant (FRGII) Award, American University of Sharjah (AUS)
05/2011 – Teaching Excellence Award (1 of 4 finalists among 165 faculty members), College of Arts & Sciences, American University of Sharjah (AUS)
05/2010 – Faculty Research Grant (FRGII) Supplementary Award, American University of Sharjah (AUS)
04/2010 – Faculty Research Grant (FRGII) Award, American University of Sharjah (AUS)
05/2009 – Faculty Research Grant (FRGII) Award, American University of Sharjah (AUS)
11/2007 – Faculty Seed Grant Award, American University of Sharjah (AUS)
04/2007 – Keystone Symposia Scholarship, Keystone Symposia Education Fund and The Macrophage: Homeostasis, Immunoregulation and Disease, Keystone Symposia
03/2007 – Keystone Symposia Scholarship , National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and Metabolic Syndrome and Cardiovascular Risk, Keystone Symposia
10/2006 – Merck Frosst Biology Research Day 1st Place Prize, 6th Biology Research Day and Merck Frosst Canada Ltd. (Kirkland, QC, Canada)
10/2006 – Merck Frosst Biology Research Day Travel Award, 6th Biology Research Day and Merck Frosst Canada Ltd. (Kirkland, QC, Canada)
05/2006 – The Doug Hogue Award, Department of Biochemistry & Molecular Biology, Faculty of Medicine and Dalhousie University (Halifax, NS, Canada)
05/2006 – Andres Petrasovits Award (Trophy), Canadian Cardiovascular Society, Faculty of Medicine, University of Manitoba (Winnipeg, MB, Canada)
05/2006 – Heart & Stroke Foundation of Nova Scotia Award, 3rd National Research Forum for Young Investigators, HSFNS
04/2006 – Keystone Symposia Scholarship, National Heart, Lung and Blood Institute (NHLBI), Atherothrombosis, Keystone Symposia
02/2006 – Keystone Symposia Scholarship (National Heart, Lung and Blood Institute (NHLBI), Molecular Mechanisms of Heart Disease and Regeneration, Keystone Symposia
01/2003-06/2006 – Graduate Research Funding Studentship, Department of Biochemistry & Molecular Biology, Faculty of Medicine, Dalhousie University (Halifax, NS, Canada)
12/2005 – Research Capacity Student Award, Nova Scotia Health Research Foundation (Halifax, NS, Canada)
12/2005 – Graduate Student Conference Travel Grant, Faculty of Graduate Studies and Dalhousie University(Halifax, NS, Canada)
09/2003 – Biochemistry & Molecular Biology Graduate Entrance Scholarship, Department of Biochemistry & Molecular Biology, Faculty of Medicine, Dalhousie University (Halifax, NS, Canada)
02/2003 – Graduate Studies & Research Dean’s Honour List, Faculty of Graduate Studies & Research and McGill University (Montreal, QC, Canada)
09/2000-12/2002 – Graduate Research Funding Studentship, Department of Microbiology & Immunology, Faculty of Medicine and McGill University (Montreal, QC, Canada)
09/1997-05/2000 – Science Dean’s Honour List, Faculty of Science and Dalhousie University (Halifax, NS, Canada) 06/1999 – NSERC Undergraduate Research Award, Department of Microbiology & Immunology, Faculty of Medicine and Dalhousie University (Halifax, NS, Canada)
09/1999 – John E. Jordon Scholarship, Dalhousie University (Halifax, NS, Canada) 05/1998 – Burgess McKittrick Prize in Physics, Department of Physics and Dalhousie University (Halifax, NS, Canada)

Publications

Peer-Reviewed Publications

Referred and Indexed Journal Articles

1. Gunasekar CJ, Abu-Yousef IA, Majdalawieh A, Narasimhan S. Assessment of Magnesium Content in the Extracts and Manufactured Formulations of the Medicinal Plant Rauwolfia Serpentina. European Journal of Scientific Research. 2014; 121(4): 427-436.
2. Majdalawieh A, Kanan MC, El-Kadri O, Kanan SM. Recent Advances in Gold and Silver Nanoparticles: Synthesis and Applications. Journal of Nanoscience and Nanotechnology . 2014; 14(7): 4757-4780.
3. Mohammed OG, Assaleh KT, Husseini GA, Majdalawieh A, Woodward SR. Novel Algorithms for Accurate DNA Base-Calling. Journal of Biomedical Science and Engineering . 2013; 6(2): 165-174. doi: 10.4236/jbise.2013.62020
4. Narasimhan S,Majdalawieh A, Abu-Yousef IA, Dhivya S, Ramasubramanian V. Evaluation of the Interaction Potential of Synthetic Ethylene Glycol Compounds with Nuclear Factor κB. Mediterranean Journal of Chemistry. 2013; 2(3): 471-483.
5. Holloway RW, Bogachev O, Bharadwaj AG, et al. Stromal Adipocyte Enhancer-Binding Protein 1 (AEBP1) Promotes Mammary Epithelial Cell Hyperplasia via Proinflammatory and Hedgehog Signaling. Journal of Biological Chemistry. 2012; 287(46): 39171-39181. doi: 10.1074/jbc.M112.404293
6. Dawoud J, Fasfous I, Majdalawieh A. A Density Functional Theory Study of the Cu+•O2 and Cu+•N2 Adducts. ZeitschriftfürNaturforschung-Section B . Journal of Chemical Sciences. 2012 67(2): 118-126
7. Zhang L, Reidy SP, Bogachev O, Hall BK, Majdalawieh A, Ro HS. Lactation Defect with Impaired Secretory Activation in AEBP1-Null Mice. PLOS One. 2011; 6(11): e27795. doi: 10.1371/journal.pone.0027795
8. Bogachev O, Majdalawieh A, Pan X, Zhang L, Ro HS. Adipocyte Enhancer-Binding Protein 1 (AEBP1) (a Novel Macrophage Pro-Inflammatory Mediator) Over-Expression Promotes and Ablation Attenuates Atherosclerosis in ApoE-/- and LDLR-/- mice. Molecular Medicine. 2011; 17(9-10): 1056-1064. doi: 10.2119/molmed.2011.00141
9. Majdalawieh A, Hmaidan R, Carr R. Nigella sativa Modulates Splenocyte Proliferation, Th1/Th2 Cytokine Profile, Macrophage Function and NK Anti-Tumor Activity. Journal of Ethnopharmacology. 2010; 131(2): 268-275. doi: 10.1016/j.jep.2010.06.030
10. Majdalawieh A, Carr R. In Vitro Investigation of the Potential Immunomodulatory and Anti-Cancer Activities of Black Pepper (Piper nigrum) and Cardamom (Elettariacardamomum). Journal of Medicinal Food. 2010; 13(2): 371-381. doi: 10.1089/jmf.2009.1131
11. Majdalawieh A, Ro HS. Regulation of IκBα Function and NF-κB Signaling: AEBP1 is a Novel Pro-inflammatory Mediator in Macrophages. Mediators of Inflammation . 2010. doi: 10.1089/jmf.2009.1131
12. Majdalawieh A, Ro HS. PPARγ1 and LXRα Face a New Regulator of Macrophage Cholesterol Homeostasis and Inflammatory Responsiveness, AEBP1. Nuclear Receptor Signaling. 2010; 8: e004.
13. Majdalawieh A, Ro HS. LPS-Induced Suppression of Macrophage Cholesterol Efflux is Mediated by Adipocyte Enhancer-Binding Protein 1. International Journal of Biochemistry and Cell Biology. 2009; 41(7): 1518-1525. doi: 10.1016/j.biocel.2009.01.003
14. Miller JR, Siripurkpong P, Hawes J, Majdalawieh A, RoHS, McLeod RS. The trans-10, cis-12 Isomer of Conjugated Linoleic Acid Decreases Adiponectin Assembly by PPARγ-dependent and PPARγ-independent Mechanisms. Journal of Lipid Research. 2008; 49(3): 550-562. doi: 10.1194/jlr.M700275-JLR200
15. Majdalawieh A, Zhang L, Ro HS. Adipocyte Enhancer-Binding Protein-1 Promotes Macrophage Inflammatory Responsiveness by Up-regulating NF-κB via IκBalpha Negative Regulation. Molecular Biology of the Cell. 2007; 18: 930-942.
16. Ro HS, Zhang L, Majdalawieh A, et al. Adipocyte Enhancer-Binding Protein 1 Modulates Adiposity and Energy Homeostasis. Obesity. 2007; 15(2): 288-302. doi: 10.1038/oby.2007.569
17. Majdalawieh A, Zhang L, Fuki IV, Rader DJ,Ro HS. Adipocyte Enhancer-Binding Protein-1 is a Potential Novel Pro-atherogenic Factor Involved in Macrophage Cholesterol Homeostasis and Inflammation. Proceedings of the National Academy of Sciences USA . 2006; 103(7): 2346-2351.
18. Zhang L,Reidy SP, Nicholson TE, et al. The Role of AEBP1 in Sex-Specific Diet-Induced Obesity. Molecular Medicine. 2005; 11(1-12): 39-47.