Adil I. Khan, MSc, PhD


Assistant Professor
Department of Pathology and Laboratory Medicine
Director, Point of Care Testing and Clinical Chemistry
Temple University Health System
100 E. Lehigh Avenue
Philadelphia, PA 19125, USA

Biography

Dr. Khan is the Director of Point of Care Testing at Temple University and Episcopal Hospitals and Director of the Chemical Pathology Laboratories at Temple University Episcopal Hospital and Northeastern Ambulatory Care Center, Philadelphia, Pennsylvania, USA. He also holds an academic appointment at Temple University School of Medicine as an Assistant Professor of Pathology. In addition to this he is also the Chair for the Philadelphia Section of the American Association for Clinical Chemistry and is an elected representative for United States in the International Federation of Clinical Chemistry and Laboratory Medicine Task Force on Point of Care Testing. He has been the recipient of the American Association for Clinical Chemistry Recognition Award in 2007, 2008, 2009, 2010, 2012 and 2013.

Research Interest

His research interests include: Understanding the role of adhesion molecules in leukocyte recruitment in health and disease; identifying novel markers of inflammation; clinical trials of point of care testing devices and clinical laboratory instruments.

Scientific Activities

HONORS AND AWARDS

• (2013) Clinical Chemist Recognition Award (American Association for Clinical Chemistry)
• (2013) Faculty of the Year Award For Teaching, Temple University
• (2012) Clinical Chemist Recognition Award (American Association for Clinical Chemistry)
• (2010) Clinical Chemist Recognition Award (American Association for Clinical Chemistry)
• (2010) Visiting Professor, Women Medical College Shield of Appreciation, Pakistan
• (2009) Clinical Chemist Recognition Award (American Association for Clinical Chemistry)
• (2008) Clinical Chemist Recognition Award (American Association for Clinical Chemistry)
• (2008) Visiting Professor, Ayub Medical College Shield of Appreciation, Pakistan
• (2008) Visiting Professor, Riphah International University Shield of Appreciation, Pakistan
• (2007) Clinical Chemist Recognition Award (American Association for Clinical Chemistry)
• (2007) Team leader & Inspector for College of American Pathologists
• (2004) University of Texas Southwestern Medical Center Clinical Chemistry Fellowship, USA
• (2001) CIHR Group Grant Postdoctoral Research Fellowship, Canada
• (1997) GlaxoWellcome PhD Scholarship, UK

MEMBERSHIPS

• Member, Glycemic Control Taskforce
• Member, Episcopal Hospital Performance Improvement Committee
• Member, Pathology Residency Program Evaluation Committee
• Member, Pathology Residency Program Clinical Competency Committee

Publications

RESEARCH PUBLICATIONS

1. Patel V, Qiu J, Wang J, et al. Validation and Correlation study of the Values for the Beckman cTnI and TnI+3 Assay on the DxI 800 and Access-2 Analyzers. AACC. 2015.
2. Grant ML, Hotchandan N, Khan AI, et al. Therapeutic Plasma Exchange for Hypertriglyceridemic Necrotizing Pancreatitis. American Society for Apheresis. 2015.
3. Qiu J, Luo X, Uthup M, Khan AI, Goldsmith BM. Validation Study for Nine Analytes in Non-Standard Body Fluids. ASCP. 2015.
4. Khan AI. Using glucose meters in the hospital environments: Some challenges and resolutions for point-of-care-testing. Point of Care. 2014; 13(3) 97-100. doi: 10.1097/POC.0000000000000031
5. Viren P, Jihui Q, Jindong W, et al. Verifying A Cut-Off Value for the Beckman TnI+3 Assay on the DxI and Access Analyzers. AACC. 2014.
6. Parajuli S, Bhattacharyya S, Hotchandani N, Khan AI, Goldsmith BM. Correlation of Automated Immunoassay (Abbott Architect i2000 SR) with Liquid Chromatography-Tandem Mass Spectrometry Method. USCAP. 2014.
7. Jin M, Khan AI. Procalcitonin: Uses in the Clinical Laboratory for the Diagnosis of Sepsis. Lab Med. 2010; 41(1): 173-177.
8. Khan AI. POCT in Acute Coronary Syndromes: ADVANCE for Administrators of the Laboratory. 2009; 18(10): 44-46.
9. Polson J, Wians FH., Jr., Orsulak P, et al. False Positive Acetaminophen Levels in Patients with Liver Injury. Clin Chim Acta. 2008; 391(1-2): 24-30. doi: 10.1016/j.cca.2008.01.018.
10. Khan AI. More POCT on CBG: MLO. Med Lab Obs. 2007; 39(11): 6.
11. Reddy V, Khan AI, Remaley A, Wians Jr. FH. An update on Point-of-Surgery Testing. Lab Med. 2006, 37(12): 754-756.
12. Khan AI, Cimo M, Hashim IA, Wians Jr. FH. Hyperammonemia in a 20-year old women: Lab Med. 2006, 37(4): 226-228. doi: 10.1309/BKNXRDVDEU44LX8P
13. Khan AI, Vasquez V, Gray J, Wians Jr. FH, Kroll MH. Variability of Results Between Point-of-Care Testing Glucose meters and Central Laboratory Analyzer. Arch Pathol Lab Med. 2006; 130(10): 1527-1532.
14. Choi T-S, Khan AI, Greilich PE, Kroll MH. Modified plasma-based ecarin clotting time assay for monitoring of recombinant hirudin during cardiac surgery. Am J Clin Pathol. 2006; 125(2): 290-295. doi: 10.1309/0TDG8BECLWCBXCDK
15. Khan AI, Susa J, Ansari MQ. Systemic sclerosis (scleroderma). Lab Med. 2005; 36(11): 723-726.
16. Khan AI, Vasquez V, Gray J, Wians Jr. FH, Kroll MH. POCT glucose meters: How useful are they in the hospitalized diabetic? Southwestern Lab Bulletin. 2005.
17. Khan AI, Vasquez V, Gray J, Kroll MH. Investigating the reliability of POCT glucose meters. Clin Chem. 2005; 51(6): A252.
18. Khan AI, Heit B, Andonegui G, Colarusso P, Kubes P. Lipo- polysaccharide: a p38 MAPK-dependent disrupter of neutrophil chemotaxis. Microcirculation. 2005; 12(5): 421-432.
19. Khan AI, Kerfoot SM, Heit B, et al. Role for CD44 and hyaluronan in neutrophil recruitment. J Immunol. 2004; 173(12): 7594-7601. doi: 10.4049/jimmunol.173.12.7594
20. Khan AI. Lab methods/instruments: Then and now-IEP versus IFE. Lab Med. 2004; 35(11): 662-663.
21. Khan AI, Kubes P. Role of CD44 in neutrophil recruitment in MIP-2 induced acute inflammation. FASEB Journal. 2003; 17(5): A1365-A1365.
22. Venturi GM, Tu LL, Kadono T, et al. Leukocyte migration is regulated by L-selectin endoproteolytic release. Immunity. 2003; 19(5): 713-724. doi: 10.1016/S1074-7613(03)00295-4
23. Venturi GM, Tu LL, Kadono T, et al. L-selectin endoproteolytic release controls leukocyte interactions with vascular endothelial cells by regulating cell surface receptor density. FASEB Journal. 2003; 17(7): C285-C285.
24. Khan AI, Kubes P. L-selectin: An emerging player in chemokine function. Microcirculation. 2003; 10(3-4): 351-358. doi: 10.1038/sj.mn.7800201
25. Kubes P, Heit B, van Marle G, et al. In vivo impairment of neutrophil recruitment during lentivirus infection. J Immunol. 2003; 171: 4801-4808. doi: 10.4049/jimmunol.171.9.4801
26. Khan AI, Landis RC, Malhotra R. L-selectin ligands in lymphocyte re-circulation and models of inflammation. Inflammation. 2003; 27(5): 265-280.
27. Khan AI, Landis RC, Malhotra R, Haskard DO. Identification and characterization of L-selectin ligands in porcine inguinal lymphoid tissues. Immunology. 2002; 105(4): 441-449. doi: 10.1046/j.1365-2567.2002.01393.x
28. Khan AI, Landis RC, Malhotra R, Haskard DO. Identification of an L-selectin ligand in peripheral lymph node conditioned medium, 9th UK Adhesion Meeting 1999, University of Birmingham, UK.
29. Khan AI, Landis RC, Mahiouz DL, Haskard DO. Identification of L-selectin ligands with mAb MECA 79 and L-selectin-Fc chimeras 6th UK Adhesion Meeting 1998 ICRF, UK.
30. Mahmood N, Piacente S, Burke A, Khan A, Pizza C. Constituents of Cuscuta reflexa are anti-HIV agents. Antiviral chemistry & chemotherapy. 1997; 8(1): 70-74
31. Mahmood N, Piacente S, Pizza C, Burke A, Khan AI, Hay AJ. The anti-HIV activity and mechanisms of action of pure compounds isolated from Rosa damascene. Biochem Biophys Res Commun. 1996; 229: 73-79. doi: 10.1006/bbrc.1996.1759
32. Arouma OI, Spenser JP, Halliwal B, et al. Antioxidant and antiviral actions of Herbor and Spice Provencal. Food & Chem Toxicology. 1996; 34: 449-456.
33. Gardiner JM, Loyns CR, Burke A, Khan A, Mahmood N. Synthesis and HIV-1 inhibition of novel benzimidazole derivatives. Bioorganic and Medicinal Chemistry Letters. 1995; 12: 1251-1254. doi: 10.1016/0960-894X(95)00203-6
34. Houghton PJ, Woldemariam TZ, Khan AI, Burke A, Hay A, Mahmood N. Antiviral activity of natural and semi-synthetic Chromone alkaloids. Antiviral Research. 1994; 25: 235-244.
35. Gardiner JM, Loyns CR, Burke A, Khan A, Mahmood N. Novel benzimidazole N-alkoxides and evaluation against HIV-1 and RT. Conf. Proc. 9th Annual AIDS workshop, UMIST, Manchester, 1995; 64.
36. Mahmood N, Burke A, Khan A, et al. Anti-HIV activity in chronically infected H9 and acutely infected C8166 cells by macrocyclic amides. Conf. Proc. 9th Annual AIDS workshop, UMIST, Manchester, 1995; 64.
37. Mahmood N, Burke A, Khan A, Chambers P, Hay A. An ELISA method for the demonstration of CD4/gp120 interactions, Conf. Proc. 8th Annual AIDS workshop, UMIST, Manchester, 1994; 95.

BOOK CHAPTER

1. Khan AI. Quality Requirements for Point of Care Testing when Traditional Systems Fail (Manuscript in Preparation). In: Kost G, Corbin C, eds. Global Point-of-Care Strategies for Disasters, Complex Emergencies, and Public Health Crisis: Enhancing Standards of Care at the Site of Need (Work). AACC Press, 2014.