Abdelali Agouni, PhD, FHEA

Lecturer in Cardiovascular Biology
Faculty of Health and Medical Sciences
School of Biosciences & Medicine | Department of Biochemistry & Physiology
University of Surrey
The Dorothy Hodgkin Building, Office 2AY02
Guildford, GU2 7XH, England, UK

Biography

Dr. Agouni started his academic career with medical studies in Algeria, and then he graduated in 2005 with an MSc (distinction) in Pharmacology from the University Louis Pasteur of Strasbourg (France). He then pursued his PhD studies in Clinical and Experimental Pharmacology at the prestigious laboratory of Neurovascular Integrated Biology (CNRS 6214-INSERM 771), University of Angers (France). After graduating with his PhD in 2008, he joined the School of Biological Sciences, University of Aberdeen (Scotland) as a post-doctoral Research Fellow. In October 2011, he joined the University of Surrey (England) as Lecturer in Cardiovascular Biology at the Faculty of Health and Medical Sciences. The University of Surrey is ranked 8th in the UK (Guardian League table 2014). Dr. Agouni is a fellow of higher education academy (FHEA) since 2013. At Surrey, Dr. Agouni has built up a research group to investigate the molecular mechanisms underpinning cardiovascular complications associated with metabolic disorders. Dr Agouni has published in the area of cardiovascular research over 20 publications, many in leading international peer-reviewed journals (e.g. Diabetes, Am. J. Respir. Crit. Care Med, Diabetologia, FASEB Journal, Am J Pathol, J Immunol, and J Pathol).

Research Interest

His research interests include: Endothelial dysfunction, obesity, diabetes, genetics of coronary artery disease, role of endoplasmic reticulum stress in diabetes and obesity, oxidative stress, role of phosphatases in insulin resistance and cardiovascular risk, angiogenesis.

Scientific Activities

ADMINISTRATIVE RESPONSIBILITIES & PROFESSIONAL MEMBERSHIPS

• Editorial Board member of “Archives of Physiology”
• Fellow of Higher Education Academy (FHEA) since November 2013.
• Organised and chaired a scientific session at the annual 24th meeting of the Group of Reflexion on Cardiovascular Research (GRRC), Tours, France, 25- 27 April 2007.
• Founding member of the Group of Reflexion on Cardiovascular Research (GRRC)’s youth club (2006)
• Founding member of Aberdeen School of Biological Sciences’ Post Doc society (2010)
• Elected member of the University of Angers (France) Scientific Council (2006 to 2008). The Scientific Council as part of the University Senate is responsible for the University’s research policy and budget.
• Full member of the Society of Physiology (France).
• Ordinary member of the Physiological Society (UK).
• Full member of the Biochemical Society (UK).
• Reviewer for international peer-reviewed journals (e.g. PloS ONE, BJP, Toxins, Circulation and Diabetes) and for national and international funding bodies (e.g. Medical Research Council, Swiss Science Foundation).

Publications

RESEARCH ARTICLES IN PEER-REVIEWED JOURNALS:

1. Grant L, Shearer K, Czopek A, et al. Myeloid-cell protein tyrosine phosphatase-1B deficiency protects against high-fat diet and lipopolysaccharide induced inflammation, hyperinsulinemia and endotoxemia through an IL-10 STAT3 dependent mechanism. Diabetes. 2013; 63(2): 456-470. doi: 10.2337/db13-0885.
2. Hoggard N, Agouni A, Mody N, and Delibegovic M. Serum Levels of Retinol Binding Protein 4 (RBP4) and Adipose Tissue Expression Levels of Protein Tyrosine Phosphatase 1B (PTP1B) are Increased in Obese Men Resident in North East of Scotland Without Any Changes in Endoplasmic Reticulum (ER) Stress Response Marker Genes. International Journal of General Medicine. 2012; 5: 403-11.
3. Alnabulsi A, Agouni A, Mitra S, et al. Cellular apoptosis susceptibility (chromosome segregation 1-like, CSE1L) gene is a key regulator of apoptosis, migration and invasion in colorectal cancer. Journal of Pathology. 2012; 4: 471-481. doi: 10.1002/path.4031.
4. Owen C, Czopek A, Agouni A, et al. Adipocyte-Specific Protein Tyrosine Phosphatase 1B Deletion Increases Lipogenesis, Adipocyte Cell Size and is a Minor Regulator of Glucose Homeostasis. PloS ONE. 2012; 7(2):e32700. doi: 10.1371/journal.pone.0032700.
5. Agouni A, Ducluzeau PH, Benameur T, et al. Microparticles from patients with metabolic syndrome induce vascular hypo-reactivity via Fas/Fas-Ligand pathway in mice. PloS ONE. 2011; 6(11): e27809. doi: 10.1371/journal.pone.0027809.
6. Agouni, A, Mody N, Owen C, et al. Liver-specific Deletion of Protein Tyrosine Phosphatase (PTP) 1B Improves Obesity- and Pharmacologically-Induced ER Stress and Reduces Oxidative and Nitrosative Stress. Biochemical Journal. 2011; 438(2):369-78. Impact factor 4.65 doi: 10.1042/BJ20110373.
7. Mody N, Agouni A, Mcilroy GD, Platt B and Delibegovic M. Susceptibility to Diet-Induced Obesity and Glucose Intolerance in APPSWE/PSEN1A246E Alzheimer Mice is Associated with Decreased Brain pAkt/PKB Phosphorylation and Increased Erk1/2 and S6 Phosphorylation and RBP4 levels. Diabetologia. 2011; 54(8):2143-51.
8. Banquet S, Delannoy E, Agouni A, et al. Role of Gi/o-Src kinase-PI3K/Akt pathway and caveolin-1 in β2-adrenoceptor coupling to endothelial NO Synthase in mouse pulmonary artery. Cellular signalling. 2011; 23(7):1136-43. doi: 10.1016/j.cellsig.2011.02.008.
9. Mastronardi ML, Mostefai HA, Soleti R, Agouni A, Martinez MC, Andriantsitohaina R. Microparticles from apoptotic monocytes enhance nitrosative stress in human endothelial cells. Fundamental & Clinical Pharmacology. 2011; 25(6):653-60. doi: 10.1111/j.1472-8206.2010.00898.x.
10. Agouni, A, Owen C, Czopek A, Mody N and Delibegović M. In vivo differential effects of fasting, re-feeding, insulin and insulin stimulation time course on insulin signalling pathway components in peripheral insulin-sensitive tissues. Biochemical and Biophysical Research Communications. 2010; 401(1): 104-111. doi: 10.1016/j.bbrc.2010.09.018.
11. Priou P, Gagnadoux F, Tesse A, et al. Endothelial nitric oxide dysfunction caused by circulating microparticles from patients with obstructive sleep apnea and severe nighttime hypoxia. American Journal of Pathology. 2010; 177(2): 974-83.
12. Agouni A, Lagrue-Lak-Hal AH, Mostefai HA, et al. Red wine polyphenols prevent metabolic and cardiovascular alterations associated with obesity in zucker fatty rats (Fa/Fa). PLoS ONE. 2009; 4(5):e5557. doi: 10.1371/journal.pone.0005557.
13. Agouni A, Lagrue-Lak-Hal AH, Ducluzeau PH, et al. Endothelial dysfunction caused by circulating microparticles from patients with metabolic syndrome. American Journal of Pathology. 2008; 173(4): 1210-1219. doi: 10.2353/ajpath.2008.080228.
14. Mostefai HA, Meziani F, Mastronardi ML, et al. Circulating microparticles from septic schock patients exert protective role on vascular function. American Journal of Respiratory and Critical Care Medicine 2008; 178(11):1148-55. doi: 10.1164/rccm.200712-1835OC.
15. Mostefai HA, Agouni A, Carusio N, et al. PI3-Kinase and Xanthine oxidase regulate NO and oxygen reactive species productions by apoptotic lymphocyte microparticles in endothelial cells.Both authors contributed equally to this work. Journal of Immunology. 2008; 180(7): 5028-5035.
16. Agouni A, Mostefai HA, Porro C, et al. Sonic hedgehog carried by microparticles corrects endothelial injury through nitric oxide release. FASEB Journal. 2007; 21(11): 2735-2741.
17. Agouni A, Sourbier C, Danilin S, et al. Parathyroid Hormone-Related Protein Induces Cell Survival through the phosphatidylinositol 3-kinase/Akt Pathway in Renal Cell Carcinoma: Evidence for a Critical Role for Integrin-Linked Kinase and Nuclear Factor kappa B. Carcinogenesis. 2007; 28(9): 1893-1901.
18. Sourbier C, Lindner V, Lang H, et al. The phosphatidylinositol 3-kinase/Akt pathway: A new target in human renal cell carcinoma therapy. Cancer Research. 2006; 66(10): 5130-5142.

REVIEW ARTICLES:

19. Agouni A, Andriantsitohaina R, Martinez MC. Microparticles as biomarkers of vascular dysfunction in Metabolic Syndrome and its individual components. Current Vascular Pharmacology. 2013;
20. Agouni A, Chalopin M, Martinez MC, Andriantsitohaina R. Protection by Red Wine Polyphenols against Metabolic and Cardiovascular Alterations Associated with Obesity: A Possible Link with Estrogen Alpha Receptor. Journal of Wine Research. 2011; 22(2): 151-157.