Associate Editor


Zhenyuan Song, PhD

Associate Professor
Department of Kinesiology and Nutrition
Department of Pathology
College of Applied Health Sciences
University of Illinois Medical Center
1919 W Taylor Street, RM 627
Chicago, IL 60612, USA

Biography

EDUCATIONAL QUALIFICATIONS

• PhD (2000 ): Nutritional Physiology and Biochemistry, University of Arkansas, Fayetteville, Arkansas, USA
• MS (1994) : Nutritional Physiology and Biochemistry, Shenyang Agricultural University, Shenyang, Liaoning, P. R. China.
• BS (1991): Animal Science, Shenyang Agricultural University, Shenyang, Liaoning, P. R. China


PROFESSIONAL EXPERIENCE

• (2010-present): Adjunct Associate Professor, Department of Pathology, School of Medicine University of Illinois at Chicago, Chicago, IL
• (2014-present): Associate Professor (Tenured), Department of Kinesiology and Nutrition School of Applied Health Sciences, University of Illinois at Chicago, Chicago, IL
• (2008-2014): Assistant Professor, Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL
• (2005-2008): Assistant Professor, Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, University of Louisville, Louisville, KY
• (2002-2005): Research Associate, Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, University of Louisville, Louisville, KY
• (2001-2002): Postdoctoral Fellow, Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, University of Louisville, Louisville, KY
• (2000-2001): Postdoctoral Fellow, Division of Hepatology, Graduate Program of Human Nutrition, School of Medicine, University of Kentucky, Lexington, KY
• (1994-1997): Research Scientist, Biotechnology Laboratory, Research and Development Institute, Shenyang, Liaoning

Research Interest

His research interests include: Investigation of pathogenesis of fatty liver diseases, including Alcoholic Liver Disease (ASH) and metabolic syndrome-associated Non-Alcoholic Steatohepatitis (NASH) using both in vitro and in vivo models.

Scientific Activities

HONORS AND AWARDS

• 2007 Travel Award: NIH-NIAAA- International Symposium on Alcoholic Liver and Pancreatic Diseases and Cirrhosis October: 17-18, Kobe, Japan
• 2006 Travel Award: NIH-NIAAA- International Symposium on Alcoholic Liver and Pancreatic Diseases and Cirrhosis May: 18-19, Los Angeles, California
• 2005 Young Investigator Award: NIH-NIAAA-7th international symposium of cytokines and Chemokines, Montreal, Canada
• 2005 NIH Career Developing Award


MEMBERSHIPS OF PROFESSIONAL SOCIETIES

• American Association for the Study of Liver Disease (AASLD)
• American Society of Nutritional Science (ASNS)
• Research Society on Alcoholism (RSA)

Publications

1. Dou X, Xia Y, Jing Chen, Song Z, et al. Rectification of impaired adipose tissue methylation status and lipolytic response contributes to hepatoprotective effect of betaine supplementation in a mouse model of alcoholic liver disease. The British Journal of Pharmacology. 2014; 171: 4073-86. doi: 10.1111/bph.12765.
2. Sun S, Song Z, Cotler SJ, Cho M. Biomechanics and functionality of hepatocytes in liver cirrhosis. J Biomech. 2014; 47: 2005-2010. doi: 10.1016/j.jbiomech.2013.10.050.
3. Wang Z, Dou X, Li S, Zhang X, Shen C, Song Z. Nrf2 activation-induced hepatic VLDL receptor overexpression in response to oxidative stress contributes to alcoholic liver disease in mice. Hepatology. 2014; 59: 1381-92. doi: 10.1002/hep.26912.
4. Li S, Li J, Shen C, Zhang X, Song Z. Tert-butylhydroquinone (tBHQ) protects hepatocytes against lipotoxicity via inducing autophagy independently of Nrf2 activation. BBA-Molecular and cell biology of lipids. 2014; 1841: 22-33. doi: 10.1016/j.bbalip.2013.09.004.
5. Zhang X, Wang Z, Gu D, Li S, Shen C, Song Z. Increased 4-hydroxynonenal Formation Contributes to Obesity-related Lipolytic Activation in Adipocytes. PLoS One. 2013; 8: e70663. doi: 10.1371/journal.pone.0070663.
6. Zhong W, Zhao Y, Sun X, Song Z, McClain CJ, Zhou Z. Dietary zinc deficiency exaggerates ethanol-induced liver injury in mice: involvement of intrahepatic and extrahepatic factors. PLoS One. 2013; 8(10): e76522. doi: 10.1371/journal.pone.0076522.
7. Gu D, Wang Z, Dou X, Vu L, Yao T, Song Z. Inhibition of ERK1/2 Pathway Suppresses Adiponectin Secretion via Accelerating Protein Degradation by Ubiquitin-Proteasome System: Relevance to Obesity-related Adiponectin Decline. Metabolism: Clinical and Experimental. 2013; 62: 1137-48. doi: 10.1016/j.metabol.2013.01.025.
8. Dou X, Shen C, Wang Z, Li S, Zhang X, Song Z. Protection of nicotinic acid against oxidative stress-induced cell death in hepatocytes contributes to its beneficial effect on alcohol-induced liver injury in mice. J Nutr Biochem. 2013; 24: 1520-1528. doi: 10.1016/j.jnutbio.2012.12.012.
9. Dou X, Li S, Wang Z, Gu D, Shen C, Yao T, Song Z. Inhibition of NF-kB activation by 4-hydroxynonenal contributes to liver injury in a mouse model of alcoholic liver disease. American Journal of pathology. 2012; 181: 1702-1710. doi: 10.1016/j.ajpath.2012.08.004.
10. Wang Z, Dou X, Song Z, et al. 4-Hydroxynonenal Differentially Regulates Adiponectin Gene Expression and Secretion via Activating PPAR-gamma and Accelerating Ubiquitin-Proteasome Degradation. Molecular and Cellular Endocrinology. 2012; 349: 222-231. doi: 10.1016/j.mce.2011.10.027.
11. Wang Z, Dou X,Yao T, Song Z. Homocysteine Inhibits Adipogenesis in 3T3-L1 Preadipocytes. Experimental Biology and Medicine. 2011; 236: 1379-1388. doi: 10.1258/ebm.2011.011234.
12. Dou X, Wang Z, Yao T, Song Z. Cysteine aggravates palmitate induced cell death in hepatocytes. Life Sci. 2011; 89: 879-885. doi: 10.1016/j.lfs.2011.09.022
13. Wang Z, Pini M, Song Z, et al. Homocysteine suppresses lipolysis in adipocytes by activating the AMPK pathway. Am J Physiol Endocrinol Metab. 2011; 301: E703-E712. doi: 10.1152/ajpendo.00050.2011
14. Watson WH, Song Z, Kirpich IA, Deaciuc IV, Chen T, McClain CJ. Ethanol exposure modulates hepatic S-adenosylmethionine and S-adenosylhomocysteine levels in the isolated perfused rat liver through changes in the redox state of the NADH/NAD(+) system. Biochim Biophys Acta. 2011; 1812: 613-618. doi: 10.1016/j.bbadis.2011.01.016
15. Zhao Y, Zhong W, Song Z, et al. Zinc deprivation mediates alcohol-induced hepatocyte IL-8 analog expression in rodents via an epigenetic mechanism. Am J Pathol. 2011; 179: 693-702. doi: 10.1016/j.ajpath.2011.04.006.
16. Wang Z, Yao T, Song Z. Chronic alcohol consumption disrupted cholesterol homeostasis in rats: down-regulation of low-density lipoprotein receptor and enhancement of cholesterol biosynthesis pathway in the liver. Alcohol Clin Exp Res. 2010; 34: 471-478. doi: 10.1111/j.1530-0277.2009.01111.x.
17. Wang Z, Yao T, Pini M, Zhou Z, Fantuzzi G, Song Z. Betaine improved adipose tissue function in mice fed a high-fat diet: a mechanism for hepatoprotective effect of betaine in nonalcoholic fatty liver disease. Am J Physiol Gastrointest Liver Physiol. 2010; 298: G634-G642. doi: 10.1152/ajpgi.00249.2009.
18. Wang Z, Yao T, Song Z. Extracellular signal-regulated kinases 1/2 suppression aggravates transforming growth factor-beta1 hepatotoxicity: a potential mechanism for liver injury in methionine-choline deficient-diet-fed mice. Exp Biol Med (Maywood). 2010; 35: 1347-1355. doi: 10.1258/ebm.2010.010160.
19. Wang Z, Yao T, Song Z. Involvement and mechanism of DGAT2 upregulation in the pathogenesis of alcoholic fatty liver disease. J Lipid Res. 2010; 51: 3158-3165. doi: 10.1194/jlr.M007948
20. Kang X, Zhong W, Song Z, et al. Zinc supplementation reverses alcohol-induced steatosis in mice through reactivating hepatocyte nuclear factor-4 alpha and peroxisome proliferator-activated receptor-alpha. Hepatology. 2009; 50: 1241-1250. doi: 10.1002/hep.23090.
21. Song M, Song Z, Barve S, et al. Tetrathiomolybdate protects against bile duct ligation-induced cholestatic liver injury and fibrosis. J Pharmacol Exp Ther. 2008; 325: 409-416. doi: 10.1124/jpet.107.131227.
22. Kang X, Song Z, McClain CJ, Kang YJ, Zhou Z. Zinc supplementation enhances hepatic regeneration by preserving hepatocyte nuclear factor-4 in mice subjected to a long-term ethanol administration. American Journal of Pathology. 2008; 172: 916-925. doi: 10.2353/ajpath.2008.070631.
23. Zhou Z, Liu J, Song Z, McClain CJ, Kang YJ. Inhibition by zinc supplementation of hepatic apoptosis in mice subjected to long term ethanol exposure. Exp Biol Med (Maywood). 2008; 233: 540-548. doi: 10.3181/0710-RM-265.
24. Song Z, Zhou Z, Deaciuc I, Chen T, McClain CJ. Homocysteine-induced Inhibitory Effects on Adiponectin Production in Alcoholic Liver Disease. Hepatology. 2008; 47: 867-79.
25. Deaciuc IV, Song Z, Peng X, McClain CJ. Gemone-wide transcriptome expression in the liver of a mouse model of high carbohydrate diet-induced liver steatosis and its significance for the disease. Hepatology International. 2008; 2(1): 39-49. doi: 10.1007/s12072-007-9025-2.
26. Song Z, Song M, Lee DY, Liu Y, Deaciuc IV, McClain CJ. Silymarin prevents palmitate-induced lipotoxicity in HepG2 cells: involvement of maintenance of Akt kinase activation. Basic Clin Pharmacol Toxicol. 2007; 101: 262-268. doi: 10.1111/j.1742-7843.2007.00116.x
27. Song Z, Deaciuc I, Zhou Z, et al. Involvement of AMP-activated Protein Kinase in Beneficial Effects of Betaine on High-Sucrose Diet-Induced Hepatic Steatosis. Am J Physiol Gastrointest Liver Physiol. 2007; 293: G894 -G902. doi: 10.1152/ajpgi.00133.2007
Song Z, Zhou Z, Song M, et al. Alcohol-induced S-adenosylhomocysteine accumulation in the liver sensitizes to TNF hepatotoxicity: Possible involvement of mitochondrial S-adenosylmethionine transport. Biochemical Pharmacology. 2007; 74: 521-531. doi: 10.1016/j.bcp.2007.05.005
28. Zhou Z, Kang X, Song Z, et al. Preservation of hepatocyte nuclear factor-4alpha is associated with zinc protection against TNF-alpha hepatotoxicity in mice. Exp Biol Med (Maywood). 2007; 232: 622-628.
29. De Villiers WJ, Song Z, Nasser MS, Deaciuc IV, McClain CJ. 4-Hydroxynonenal-induced apoptosis in rat hepatic stellate cells: Mechanistic approach. J Gastroenterol Hepatol. 2007; 22: 414-422. doi: 10.1111/j.1440-1746.2006.04625.x
30. Gobejishvili L, Barve S, Joshi-Barve S, Uriarte S, Song Z, McClain CJ. Chronic ethanol mediated decrease in cAMP primes macrophages to enhanced LPS-inducible NF-{kappa}B activity and TNF expression: relevance to alcoholic liver disease. Am J Physiol Gastrointest Liver Physiol. 2006; 291: G681-688. doi: 10.1152/ajpgi.00098.2006
31. Song Z, Deaciuc I, Song M , et al. Silymarin Protects Against Acute Ethanol Induced Hepatotoxicity in Mice. Alcoholism: Clinical and Experimental Research. 2006; 30: 407-413. doi: 10.1111/j.1530-0277.2006.00063.x
32. Wang J, Song Y, Song Z, et al. Cardiac metallothionein induction plays the major role in the prevention of diabetic cardiomyopathy by Zinc supplementation. Circulation. 2006; 113: 544-554.
33. Deaciuc IV, Song Z, McClain CJ. Lessons from large-scale gene profiling of the liver in alcoholic liver disease. Hepatol Res. 2005; 31: 187-192. doi: 10.1016/j.hepres.2005.02.004
34. McClain C, Barve S, Song Z, et al. Dysregulated cytokine metabolism, altered hepatic methionine metabolism and proteasome dysfunction in alcoholic liver disease. Alcohol Clin Exp Res. 2005; 29: 180S-188S.
35. Zhou Z, Wang L, Song Z, Saari JT, McClain CJ, Kang YJ. Zinc supplementation prevents alcoholic liver injury in mice through attenuation of oxidative stress. Am J Pathol. 2005; 166: 1681-1690. doi: http://dx.doi.org/10.1016/S0002-9440(10)62478-9
36. Song Z, Uriarte S, Chen T, Barve S, Hill D, McClain CJ. S-adenosylmethionine (SAMe) Modulates Interleukin-10 and Interleukin-6, But Not TNF, Production Via the Adenosine (A2) Receptor in LPS-stimulated Monocytes. Biochim Biophys Acta. 2005; 1743: 205-213. doi: 10.1016/j.bbamcr.2004.12.001
37. Uriarte SM, Joshi-Barve S, Song Z, et al. Inhibition of Akt kinase induces Caspase-8 activity, FasL expression and enhances FasL Dependent Cell Death in Juktat T Lymphocytes. Cell Death Differ. 2005; 12: 233-242.
38. Song Z, Zhou Z, Uriarte S, et al. S-adenosylhomocysteine sensitizes to TNF-alpha hepatotoxicity in mice and liver cells: a possible etiological factor in alcoholic liver disease. Hepatology. 2004; 40: 989-997. doi: 10.1002/hep.20412
39. Song Z, Barve B, Chen T, et al. S-Adenosylmethionine Modulates Endotoxin Stimulated Interleukin-6 Production in Monocytes. Cytokine. 2004; 28: 214-223. doi: 10.1016/j.bbamcr.2004.12.001
40. Lambert JC, Zhou Z, Wang L, Song Z, McClain CJ, Kang YJ. Preservation of Intestinal Structural Integrity by Zinc Is Independent of Metallothionein in Alcohol-intoxicated Mice. Am J Pathol. 2004; 164: 1959-1966. doi: http://dx.doi.org/10.1016/S0002-9440(10)63756-X
41. Zhou Z, Wang L, Song Z, Saari J, McClain CJ, Kang YJ. Abrogation of nuclear factor-kappaB activation is involved in zinc inhibition of lipopolysaccharide-induced tumor necrosis factor-alpha production and liver injury. Am J Pathol. 2004; 164: 1547-1556. doi: http://dx.doi.org/10.1016/S0002-9440(10)63713-3
42. Song Z, McClain CJ, Chen T. S-adenosylmethionine (SAMe) Protects against Acetaminophen- Induced Hepatotoxicity in mice. Pharmacology. 2004; 71: 199-208. doi: 10.1159/000078086
43. Song Y, Song Z, Zhang L, McClain CJ, Kang YJ, Cai L. Diabetes Enhances LPS-induced Cardiac Toxicity in Mouse model. Cardiovascular Toxicology. 2003; 363-372.
44. Zhou Z, Wang L, Song Z, McClain CJ, Kang YJ. A critical involvement of oxidative stress in acute alcohol-induced hepatic TNF-alpha production. Am J Pathol. 2003; 163: 1137-1146. doi: http://dx.doi.org/10.1016/S0002-9440(10)63473-6
45. Song Z, Zhou Z, Chen T, et al. S-adenosylmethionine (SAMe) protects against acute alcohol induced hepatotoxicity in mice. The Journal of Nutritional Biochemistry 2003; 14: 51-597. doi: http://dx.doi.org/10.1016/S0955-2863(03)00116-5
46. Song Z, Barve B, Chen T, et al. S-adenosylmethionine Modulates Endotoxin Stimulated Interleukin-10 Production in Monocytes. Am J Physiol Gastrointest Liver Physiol. 2004; 284: G949-G955. doi: 10.1152/ajpgi.00426.2002
47. Lambert JC, Zhou Z, Wang L, Song Z, McClain CJ, Kang YJ. Prevention of alterations in intestinal permeability is involved in zinc inhibition of acute ethanol-induced liver damage in mice. J Pharmacol Exp Ther. 2003; 305: 880-886. doi: 10.1124/jpet.102.047852
48. McClain CJ, Hill DB, Song Z, Deaciuc I, Barve S. Monocyte activation in alcoholic liver disease. Alcohol. 2002; 27: 53-61. doi: http://dx.doi.org/10.1016/S0741-8329(02)00212-4