Chandana B. Herath, PhD
Senior Research Fellow
Head of Hepatology Research Laboratory
Department of Medicine
The University of Melbourne
Level 7, Lance Townsend Building
Austin Health, 145 Studley Road
Heidelberg, Victoria 3084, Australia
Dr. Herath, a hepatologist, is a Senior Research Fellow of the Department of Medicine of the University of Melbourne at Austin Health. Upon successful completion of his JSPS (Japan Society for the Promotion of Science) postdoctoral studies in the department of veterinary medicine at the Tokyo University of Agriculture and Technology in Tokyo, Japan, Dr. Herath joined the department of medicine of the faculty of medicine, dentistry and health sciences of the University of Melbourne in 2004.
As head of hepatology laboratory Dr. Herath has made a significant contribution towards developing animal models of liver diseases to study and formulate therapies to treat patients with liver disease including cirrhosis. He was successful in securing nationally competitive grants, amounting to over AU$ 2 million from National Health and Medical Research Council of Australia. He has supervised and/or mentored a number of PhD and MD students to successful completion and currently having 4 PhD students working in a number of projects. Dr. Herath has contributed to over 50 scientific publications which include peer-reviewed papers, book chapters and abstracts, and has given a number of speeches at major scientific conferences.
Dr. Herath has a major long-standing interest in the pathogenesis of liver diseases. Majority of his research projects is concerned with the role of the alternate arm of the renin angiotensin system (RAS). Of the paramount importance is the project in which he is performing studies to determine whether gene therapy approach is beneficial for early as well as late stage cirrhosis using a number of mouse models of chronic liver diseases.
• 1999: Japan Society for the Promotion of Science (JSPS) Fellowship offered by New Zealand, Ministry of Science and Technology
• 1998: Runner-up: Young Scientist Award (New Zealand Society of Animal Production)
• 1995: Massey University PhD Scholarship
MEMBERSHIP OF PROFESSIONAL SOCIETIES (CURRENT)
• American Physiological Society (APS)
• American Association for the Advancement of Science (AAAS)
• Gastroenterological Society of Australia (GESA)
MEMBERSHIP OF PROFESSIONAL SOCIETIES (PAST)
• Japanese Society of Reproduction and Development
• Japanese Society of Endocrine Disrupter research
• American Society for the Study of Reproduction
• Examiner of Department PhD students
• Examiner of Department honors’ students
• Member, Department environment, health & safely committee (EHS)
• Member, Department BioResources Facility committee (BRF)
• Member, Department Senior Academic Staff committee
1. Rivera LR, Leung C, Pustovit RV, et al. Damage to enteric neurons occurs in mice that develop fatty liver disease but not diabetes in response to a high-fat diet. Neurogastroenterology and Motility. 2014; 26: 1188-1199. doi: 10.1111/nmo.12385
2. Leung C, Herath CB, Jia Z, et al. Dietary glycotoxins exacerbate progression of experimental fatty liver disease. Journal of Hepatology. 2014; 60: 832-838. doi: 10.1016/j.jhep.2013.11.033
3. Yeung LW, Guruge KS, Taniyasu S, Yamashita N, Angus PW, Herath CB. Profiles of perfluoroalkyl substances in the liver and serum of patients with liver cancer and cirrhosis in Australia. Ecotoxicology and Environmental Safety. 2013; 96: 139-46. doi: 10.1016/j.ecoenv.2013.06.006
4. Herath CB, Grace JA, Angus PW. Targeting the renin angiotensin system in portal hypertension. Invited Editorial Review. World Journal of Gastrointestinal Pathophysiology. 2013; 4(1): 1-11.
5. Herath CB, Mak KY, Burrell LM, Angus PW. Angiotensin-(1-7) reduces the portal pressure response to angiotensin II and methoxamine via an endothelial nitric oxide mediated pathway in cirrhotic rat liver. American Journal of Physiology – Gastrointestinal and Liver Physiology. 2013; 304(1): G99-G108. doi: 10.1152/ajpgi.00163.2012.
6. Grace JA, Klein S, Herath CB, et al. Activation of the MAS receptor by Angiotensin-(1-7) in the Renin-Angiotensin system mediates mesenteric vasodilatation in cirrhosis. Gastroenterology. 2013; 145(4): 874-884. doi: 10.1053/j.gastro.2013.06.036
7. Goodwin M, Herath CB, Jia Z, et al. Advanced glycation end products augment experimental hepatic fibrosis. Journal of Gastroenterology and Hepatology. 2013; 28(2): 369-376. doi: 10.1111/jgh.12042
8. Garg M, Angus PW, Burrell LM, Herath CB, Gibson PR, Lubel JS. The pathophysiological roles of the renin–angiotensin system in the gastrointestinal tract. Review. Alimentary Pharmacology and Therapeutics. 2012; 35(4): 414-428. doi: 10.1111/j.1365-2036.2011.04971.x.
9. Grace JA, Herath CB, Mak KY, Burrell LM, Angus PW. Update on new aspects of the renin-angiotensin system in liver disease: clinical implications and new therapeutic options. Review. Clinical Science (London). 2012; 123(4): 225-239. doi: 10.1042/CS20120030.
10. Sugawara K, Kizaki K, Herath CB, Hasegawa Y, Hashizume K. Transforming growth factor beta family expression at the bovine feto-maternal interface. Reproductive Biology and Endocrinology. 2010; 8: 120. doi: 10.1186/1477-7827-8-120.
11. Neo JH, Ager EI, Angus PW, Zhu J, Herath CB, Christophi C. Changes in the rennin angiotensin system during the development of colorectal cancer liver metastases. BMC Cancer. 2010. doi: 10.1186/1471-2407-10-134.
12. Kemp W, Kompa A, Phrommintikul A, et al. Urotensin II modulates hepatic fibrosis and portal haemodynamic alterations in rats. American Journal of Physiology – Gastrointestinal and Liver Physiology. 2009. doi: 10.1152/ajpgi.00127.2009.
13. Herath CB, Lubel JS, Jia Z, et al. Portal pressure responses and angiotensin peptide production in rat liver are determined by relative activity of ACE and ACE2. American Journal of Physiology - Gastrointestinal and Liver Physiology. 2009; 297: G98-G106. doi: 10.1152/ajpgi.00045.2009
14. Lubel JS, Herath CB, Tchongue J, et al. Angiotensin-(1-7), an alternative metabolite of the renin-angiotensin system, is up-regulated in human liver disease and has antifibrotic activity in the bile-ductligated rat. Clinical Science. 2009; 117: 375-386. doi: 10.1042/CS20080647
15. Lubel JL, Herath CB, Burrell LM, Angus PW. Liver disease and the renin-angiotensin system – recent discoveries and clinical implications. Review. Journal of Gastroenterology and Hepatology. 2008; 23: 1327-1338. doi: 10.1111/j.1440-1746.2008.05461.x
16. Lubel JS, Herath CB, Velkoska E, Casley DJ, Burrell LM, Angus PW. Angiotensin converting enzyme 2 (ACE2) activity in fetal calf serum: implications for cell culture research. Cytotechnology. 2008; 58: 119-126. doi: 10.1007/s10616-009-9185-0
17. Herath CB, Warner FW, Lubel JL, et al. Upregulation of hepatic ACE2 expression and activity mediates a major increase in plasma angiotensin-(1-7) levels in experimental biliary fibrosis. Journal of Hepatology. 2007; 47: 387-395.
18. Herath CB, Ishiwata H, Shiojima S, et al. Developmental aberrations of liver gene expression in bovine fetuses derived from somatic cell nuclear transplantation. Cloning and Stem Cells. 2006; 8: 79-95. doi: 10.1089/clo.2006.8.79.
19. Ushizawa K, Herath CB, Kaneyama K, et al. cDNA Microarray analysis of bovine embryo gene expression profiles during the implantation period. Reproductive Biology and Endocrinology. 2004; 24: 77-84. doi: 10.1186/1477-7827-2-77
20. Herath CB, Watanabe G, Jin W, et al. Adverse effects of environmental toxicants, octylphenol and bisphenol A, on male reproductive functions in pubertal rats. Endocrine. 2004; 25: 163-172. doi: 10.1385/ENDO:25:2:163
21. Herath CB, Shiojima S, Ishiwata H, et al. Pregnancy-associated changes in genome-wide gene expression profiles in the liver of cow throughout pregnancy. Biochemical and Biophysical Research Communication. 2004; 313: 666-680. doi: 10.1016/j.bbrc.2003.11.151
22. Yamauchi N, Takezawa T, Kizaki K, Herath CB, Hashizume K. Proliferative potential of endometrial stromal cells, and endometrial and placental expression of cyclin in the bovine. Journal of Reproduction and Development. 2003; 49: 553-560. doi: http://dx.doi.org/10.1262/jrd.49.553
23. Yamauchi N, Kizaki K, Yamada O, Takahashi T, Herath CB, Hashizume K. Expression of integrin subunits depends on bovine endometrial stromal cells cultured in vitro. Connective Tissue. 2003; 35: 1-7.
24. Tanaka Y. Ttaniyama H, Tsunoda N, Herath CB, et al. Localization and secretion of inhibins in the equine fetal ovaries. Biology of Reproduction. 2003; 68: 328-335. doi: 10.1095/biolreprod.102.003749
25. Jin W, Herath CB, Yoshida M, Arai ky, et al. Inhibin B regulating follicle-stimulating hormone secretion during testicular recrudescence in the male golden hamster. Journal of Andrology. 2002; 23: 845-853. doi: 10.1002/j.1939-4640.2002.tb02343.x
26. Shi F, Petroff BK, Herath CB, Ozawa M, Watanabe G, Taya K. Serous cysts are a benign component of the cyclic ovary in the guinea pig with an incidence dependent upon inhibin bioactivity. Journal of Veterinary Medical Science. 2002; 64: 129-135. doi: http://dx.doi.org/10.1292/jvms.64.129
27. Tanaka Y, Taniyama H, Tsunoda N, et al. The testis as a major source of circulating inhibins in the male equine fetus during the second half of gestation. Journal of Andrology. 2002; 23: 229-236. doi: 10.1002/j.1939-4640.2002.tb02619.x
28. Herath CB, Yamashita M, Watanabe G, et al. Regulation of follicle-stimulating hormone secretion by estradiol and dimeric inhibins in the infantile female rat. Biology of Reproduction. 2001; 65: 1623-1633. doi: 10.1095/biolreprod65.6.1623
29. Jin W, Arai KY, Herath CB, et al. Inhibins in the male Gottingen miniature pig: Leydig cells are the predominant source of inhibin B. Journal of Andrology. 2001; 22: 953-960. doi: 10.1002/j.1939-4640.2001.tb03435.x
30. Wang H, Herath CB, Xia G, Watanabe G, Taya K. Superovulation, fertilization and in vitro embryo development in mice after administration of an inhibin-neutralizing antiserum. Reproduction. 2001; 122: 809-816. doi: 10.1530/rep.0.1220809
31. Herath CB, Watanabe G, Wanzhu J, et al. Elevated levels of inhibin-A and immunoreactive inhibin in aged male Wistar rats with testicular Leydig cell tumor. Journal of Andrology. 2001; 22: 838-846. doi: 10.1002/j.1939-4640.2001.tb02589.x
32. Herath CB, Watanabe G, Katsuda S-Ichi, Yoshida M, Suzuki AK, Taya K. Exposure of neonatal female rats to p-tert-octylphenol disrupts afternoon surges of luteinizing hormone, follicle-stimulating hormone and prolactin secretion, and interferes with sexual receptive behavior in adulthood. Biology of Reproduction. 2001; 64: 1216-1224. doi: 10.1095/biolreprod64.4.1216
33. Jin W, Wada S, Arai YK, et al. Testicular secretion of inhibin in male golden hamster (Mesocricetus auratus). Journal of Andrology. 2001; 27: 207-211. doi: 10.1002/j.1939-4640.2001.tb02173.x
34. Kondo M, Udono T, Jin W, et al. Secretion of inhibin A and inhibin B throughout pregnancy and early postpartum period in chimpanzees. Journal of Endocrinology. 2001; 168: 257-262. doi: 10.1677/joe.0.1680257
35. Herath CB, Reynolds GW, Mackenzie DD, Davis SR, Harris PM. Vagotomy suppresses cephalic phase insulin release (CPIR) in sheep. Experimental Physiology. 1999; 84: 559-569.
36. Herath CB, Reynolds GW, Mackenzie DD, Davis SR, Harris PM. The role of the vagal innervation of the gut in insulin release in lactating ewes. Proceedings of New Zealand Society of Animal Production. 1996; 56: 110-113.