Associate Editor


Glen N. Gaulton, PhD

Executive Vice Dean and Chief Scientific Officer
Professor of Pathology and Laboratory Medicine
Perelman School of Medicine
University of Pennsylvania
USA

Biography

Dr. Gaulton is the Executive Vice Dean and Chief Scientific Officer, and Professor of Pathology and Laboratory of Medicine at the University of Pennsylvanias Perelman School of Medicine. Dr. Gaultons responsibilities are to oversee both the Office of the Executive Vice Dean and Chief Scientific Officer and his active research laboratory. The Executive Vice Dean and Chief Scientific Officer leads the Schools research and research training enterprise and is responsible for both stimulating new research endeavours and providing the optimal intellectual and administrative support for ongoing research programs. This includes the Office of the Executive Vice Dean and Chief Scientific Officer, Biomedical Graduate Studies, Biomedical Postdoctoral Programs, Combined Degree and Physician Scholar Programs, Corporate Research, Clinical Research, Global Health, Masters Programs, and Research Program Development. Dr. Gaulton received his PhD in Biochemistry and Molecular Biology from the University of California, Santa Barbara. He conducted Postgraduate research in Immunology at the School of Public Health and School of Medicine at Harvard University. Dr. Gaulton was appointed Assistant Professor of Pathology and Laboratory Medicine, in the School of Medicine at the University of Pennsylvania, and he was subsequently appointed as Associate Professor with Tenure and is currently full Professor. Dr. Gaulton was appointed Associate Dean and Director of the Combined Degree and Physician Scholar Programs in 1993, Director of Biomedical Graduate Studies in 1995, Vice Dean for Research and Research Training in 1998, and Executive Vice Dean and Chief Scientific Officer in 2006.
Dr. Gaulton serves on the Board of Directors of two organizations, is a reviewer for nine Scholarly journals, and has been chair of four NIH study sections. Dr. Gaulton has received Numerous awards for teaching and research, including the Deans Award for Basic Science Teaching, the Berwick Memorial Teaching Award, the Lindback Award, the Harry Weaver Neuroscience Scholar Award from the National Multiple Sclerosis Society, and the Leukemia Society Scholar Award.
Dr. Gaulton has published over 100 manuscripts and texts, and directly supervised the research training of over thirty graduate students and fellows.

Research Interest

His research interests are in the area of viral pathogenesis. This work centers on a molecular description of the mechanisms that control a retrovirus- induced cell fusion and the detection of virus particles through nanotechnology.

Scientific Activities

HONORS AND AWARDS


• (1986-1990) National Multiple Sclerosis Society, Harry Weaver Scholar
• (1990) American Association of Immunologists
• (1991-1996) Leukemia Society of America Scholar
• (1994) University of Pennsylvania Leonard Berwick Teaching Award
• (1996) University of Pennsylvania Christian and Mary Lindback Teaching Award

Publications

Selected Peer-reviewed Publications


Additional recent publications of importance to the field (in chronological order)


1. Schwartz P, Gaulton GN. Addressing the needs of basic and clinical research: analysis of graduates of the University of Pennsylvania MD-PhD Program. JAMA. 1999; 281: 96-99. doi:
2. Chung M, Kizhatil K, Albritton LM, Gaulton GN. Induction of Syncytia by Neuropathogenic Murine Leukemia Viruses Depends on Receptor Density, Host Cell Determinants and the Intrinsic Fusion Potential of Envelope protein. J Virology. 1999; 73: 9377-9385. doi:
3. Majka M, Rozmyslowicz T, Honczarenko M, et al. Biological significance of the expression of HIV-related chemokine coreceptors (CCR5 and CXCR4) and their ligands by human hematopoietic cell lines. Leukemia. 2000; 14: 1821-1832. doi:
4. Majka M, Rozmyslowicz T, Ratajczak J, et al. The limited infectability by R5 HIV of CD34+ cells from thymus, cord and peripheral blood and bone marrow is explained by their ability to produce β−chemokines. Experimental Hematology. 2000; 28: 1334-1342. doi: http://dx.doi.org/10.1016/S0301-472X(00)00541-5
5. Rozmyslowicz T, Majka M, Kijowski J, et al. Platelet- and megakaryocyte-derived microparticles transfer CXCR4 receptor to CXCR4-null cells and make them susceptible to infection by X4-HIV. AIDS. 2003; 17: 33-42. doi:
6. Levinson AI, Zheng Y, Gaulton GN, Song D, Moore J, Pletcher H. Intrathymic Expression of Neuromuscular Acetylcholine Receptors and the Immunpathogenesis of Myasthenia Gravis. Immunol Res. 2003; 27: 399. doi: 10.1385/IR:27:2-3:399
7. Levinson AI, Zheng Y, Gaulton GN, et al. A new model linking intrathymic acetylcholine receptor expression and the pathogenesis of myasthenia Gravis. In Myasthenia gravis and related disorders. Ann. NY Acad. Sci. 2003; 998: 257-265. doi: 10.1196/annals.1254.027
8. Landers CM, Dugger N, Quadros M, Hoffman PM, Gaulton GN. Neuropathogenic murine leukemia virus TR1.3 induces selective syncytia formation of brain capillary endothelium. Virol. 2004; 321: 57-64. doi: 10.1016/j.virol.2003.12.002
9. Murphy SL, Honczarenko MJ, Dugger NV, Hoffman PM, Gaulton GN. Disparate regions of envelope protein regulate syncytium formation versus spongiform encephalopathy in neurological disease induced by murine leukemia virus TR. J Virol. 2004; 78: 8392-8399. doi: 10.1128/JVI.78.15.8392-8399.2004
10. Levinson AI, Song D, Gaulton GN, Zheng Y. The intrathymic pathogenesis of myasthenia gravis. Clin Dev Immunol. 2005; 11: 215-220. doi: 10.1080/17402520400001769
11. Lin G, Murphy, SL, Gaulton GN, Hoxie JA. Modification of a viral envelope glycoprotein cell-cell fusion assay by utilizing plasmid encoded bacteriophage RNA polymerase. J Virol Methods. 2005; 128: 135-142. doi: 10.1016/j.jviromet.2005.04.011
12. Murphy SL, Landers CM, Honczarenko MJ, Gaulton GN. Linkage of reduced receptor affinity and superinfection to pathogenesis of TR1.3 murine leukemia virus. J Virol. 2006; 80: 4601-4609. doi: 10.1128/JVI.80.9.4601-4609.2006
13. Murphy SL, Gaulton GN. TR1.3 Viral Pathogenesis and Syncytia Formation are Linked to Env- Gag Cooperation. J Virol. 2007; 81(19): 10777-10785. doi: 10.1128/JVI.00816-07
14. Rozmyslowicz T, Wroblewski K, Moodley J, Gaulton GN. A Decrease in the Cellular Phosphodiester to Phosphomonoester Lipid Ratio is Characteristic of HIV-1 Infection. Curr HIV Res. 2010; 8: 355-363. doi: 10.2174/157016210791330392#sthash.qFtFkXi2.dpuf
15. Rozmyslowicz T, Murphy SL, Conover DO, Gaulton GN. HIV-1 infection inhibits cytokine production in human thymic macrophages. Exp Hematol. 2010; 38: 1157-1166. doi: 10.1016/j.exphem.2010.08.009
16. Rozmyslowicz T, Gaulton GN. The need for a new generation of HIV diagnostics. HIV/AIDS Res Treat Open J. 2015; 1(1): e7-e8. doi: 10.17140/HARTOJ-1-e003
17. Rozmyslowicz T, Conover DO, Gaulton GN. HIV-1 infection of human thymic stromal cells and thymocytes in vitro. HIV/AIDS Res Treat Open J. 2015; 2(4): 92-96. doi: 10.17140/HARTOJ-2-116