Surgical Research - Open Journal
Research Assistant Professor
Department of Surgery
College of Medicine Tucson
Tucson, AZ 85750, USA
PhD in Physiology& Biophysics / Nephrology, 1995
University of Lund, Lund, Sweden
Bachelor of Medicine, M.B.B.Ch, MD, 1982
Zagazig University,Zagazig, Egypt
Bachelor of Surgery, M.B.B.Ch, MD, 1982
Zagazig University, Zagazig, Egypt
Summary of research interests
1. The study of the control mechanisms of the microcirculation; and their perturbation in traumatic hemorrhage, sepsis and septic shock; osmotic stress, and ageing.
2. The pathophysiology of concurrent trauma and exsanguinations, including traumatic brain injury at the molecular, cellular, tissue, and organism levels. The overall goal of my research is to device viable new interventions that efficiently and effectively improve management outcome.
3. Personalized therapy in traumatic injuries including precision resuscitation strategies targeting critical pathways and adaptive pathophysiologic events at the molecular, cellular, and tissue levels.
4. The study of the physiologic and biophysical control mechanisms that govern solute and water exchanges across the blood-peritoneal barrier during peritoneal dialysis (PD); and the perturbations of these exchange functions by factors in the PD system that either individually or synergistically influencing the functions of the blood-peritoneal barrier during PD; and ininciting PD-technique failure or limiting PD-technique survival after long-term use. Host-related factors are: 1) Aging; 2) Kidney injury; 3) Vascular and Interstitial remodeling; and 4) Uremia. System-related factors are: 1) Peritoneal indwelling catheter as a foreign body; 2) Bio-incompatibility of the clinical glucose-based PD solutions; 3) Mechanical (intraperitoneal hydrostatic pressure)/ osmotic load (hyper-osmolality) pressers; and 4) the immune response to PD and the PD-related peritonitis rate.
5. The peritoneal cavity as a route for drug delivery in pelvic-abdominal cancers. We apply the distributed approach in the anterior abdominal wall as a model of interstitial convection. This tumor-bearing model allows for the in vivo study of tumor biology and the simultaneous measurements of the tumor’s interstitial hydrostatic pressure and the chemotherapeutics’ concentration profiles across the whole thickness of the tumor.
Chairman and founder of the first Basic Science Track of Qatar Health 2010, Doha, Qatar, 12/2010
Invited speaker and Co-Chair (Slide Forum XIII) at the 28th Annual conference on Peritoneal Dialysis, Orlando, FL, 2008
Invited speaker at the Annual Meeting on Peritoneal Dialysis, Denver, CO, 2007
Winner 2nd place and 3rd place best abstract awards, Research Louisville, 2007
Invited speaker at the Central Surgical Association meeting, Louisville, KY, 2006
Invited speaker at the Annual Meeting on Peritoneal Dialysis, San Francisco, CA, 2006
Invited speaker at the first North American Chapter of the international Society for peritoneal dialysis, Chicago, IL. 2005
Invited speaker at the 24th Annual Conference on Dialysis, San Antonio, TX, 2004
Invited speaker at the first joint meeting of the international and European Societies for peritoneal dialysis, Amsterdam, the Netherlands, 2004
Winner of the University of Louisville Performance Award, 2003
Winner of the University of Louisville Performance Award, 2002
Invited speaker at the 21st Annual Conference on Dialysis & Co-Chair, slide Forum 1, 21st Annual Conference on Dialysis, New Orleans, LA,2001
Nominated for the Maher Award of the International Society for Peritoneal Dialysis (ISPD), 2000
Invited speaker at the meeting of the International Society of Peritoneal Dialysis, Stockholm, Sweden, 1995
Winner of the Outstanding Abstract Award for the best Abstract submitted to the 14th Annual Conference on Dialysis. Orlando, FL., 1994
Professional Memberships / Volunteerism /
Member, Institutional Animal Care and Use Committee, IACUC, Qatar University, 2011-2016
Vice Chairman, IRB, Research Committee, Hamad Medical Corporation, 2011-2014
Member,Steering Committee, Translational Research Institute, 2011-2014
Member, Information System Sub-Committee, Academic Health System, Hamad Medical Corp, 2011-2013
Member,Bio-safety Committee, Hamad Medical Corporation., 2011-2013
Chairman/Organizer, 1stBasic Science Track, Qatar Health, 2010
Chairman, Basic Biomedical Research, Medical Research Center, Hamad Medical Corp., 2010-2015
Chairman/Founder, The Animal Care and Use Committee (IACUC), Hamad Medical Corp., 2009-2015
Member,Institutional Review Board, WCMC-Q (IRB), Weill Cornell Medical College, Qatar, 2010-2013
Member, Research Committee, (HMC-IRB), Hamad Medical Corp., Qatar, 2009-2013
Member,The National Vivarium Committee, Qatar, 2010, 2010-2013
Member/Judge, Research Louisville, University of Louisville, KY, 2006-2008
Student Mentor/Science Fair Judge, Manual De Ponte High School andMeyzeek Middle Schools, Louisville, KY, 2005-2007
Out-patient Director, Hospital for Chest Diseases, Gizan, Saudi Arabia, 1986-1987
Director,Hospital for Chest Diseases, Gizan, Saudi Arabia, 1988-1989
Articles in professional peer-reviewed journals
1. Zakaria ER, Althani A, Fawzi AA, Fituri OM. Molecular mechanisms of peritoneal dialysis-induced microvascular vasodilation. AdvPerit Dial 2014; 30:98-109.
2. Zakaria ER, Althani A, Fawzi AA, Fituri OM. Hyperosmolality-mediated peritoneal microvascular vasodilation is linked to aquaporin function. AdvPerit Dial 2014; 30: 63-74.
3. Ayman El-Menyar, Hassan Al Thani, El RasheidZakaria, Ahmad Zarour, MazinTuma, Husham AbdulRahman, Ashok Parchani, Ruben Peralta, RifatLatifi. Multiple Organ Dysfunction Syndrome (MODS): Is It Preventable or Inevitable? International Journal of Clinical Medicine 12/2012; 3:722-730.
4. Hurt RT, Matheson PJ, Smith JW, Zakaria ER, Shaheen SP, McClain CJ, Garrison RN. Preservation of hepatic blood flow by direct peritoneal resuscitation improves survival and prevents hepatic inflammation following hemorrhagic shock. Am J PhysiolGastrointest Liver Physiol. 2012 Nov 15; 303(10): G1144-52.
5. Matheson PJ, Li N, Harris PD, Zakaria ER, Garrison RN. Glucose-Induced Intestinal Vasodilation Via Adenosine A1 Receptors Requires Nitric Oxide but not K(+)(ATP) Channels. J JSurg Res. 2011 Jun 15; 168(2): 179-87.
6. Matheson PJ, Mays CJ, Hurt RT, Zakaria ER, Richardson JD, Garrison RN: Modulation of mesenteric lymph flow and composition by direct peritoneal resuscitation from hemorrhagic shock. Arch Surg 2009, 144(7):625-634.
7. Hurt RT, Zakaria ER, Matheson PJ, Cobb M, Parker J, Garrison RN: Hemorrhage-Induced Hepatic Injury and Hypoperfusion can be prevented by Direct Peritoneal Resuscitation. J Gastrointest Surg2009 13(4):587-94.
8. Zakaria ER, Matheson PJ, Flessner MF, Garrison RN. Hemorrhagic shock and resuscitation-mediated tissue water distribution is normalized by adjunctive peritoneal resuscitation. J Am Coll Surg2008, 206(5):970-80.
9. Matheson PJ, Harris BT, Hurt RT, Zakaria ER, Garrison RN. Enteral glutamine supplementation impairs intestinal blood flow in rats. Am J Surg. 2008 Aug; 196(2): 293-9. Epub 2008 May 7.
10. Zakaria ER, Patel AA, Li N, Matheson PJ, Garrison RN: Vasoactive components of dialysis solution. Perit Dial Int 2008 May-Jun;28(3):283-95.
11. Zakaria ER, Li N, Garrison RN. Mechanisms of direct peritoneal resuscitation-mediated splanchnic hyperperfusion following hemorrhagic shock. Shock. 2007 Apr;27 (4):436-42.
12. Li N, Harris PD, Zakaria ER, Matheson PJ, Garrison RN. Role of adenosine receptor subtypes in rat jejunum in unfed state versus glucose-induced hyperemia. J Surg Res. 2007 May 1;139 (1):51-60.
13. Zakaria ER; James E. Campbell; James C Peyton, Garrison RN. Post-resuscitation tissue neutrophil infiltration is time-dependent and organ-specific. J Surg Res. 2007 Nov;143 (1):119-25.
14. Campbell JE, Garrison RN, Zakaria ER. Clinical peritoneal dialysis solutions modulate white blood cell-intestinal vascular endothelium interaction. Am J Surg. 2006 Nov;192 (5):610-6.
15. Zakaria ER, Li N, Matheson PJ, Garrison RN. Cellular edema regulates tissue capillary perfusion following hemorrhage resuscitation. Surgery 2007; 142 (4):487-96.
16. Zakaria ER,Tsakadze NL, Garrison RN. Hypertonic saline resuscitation improves intestinal microcirculation in arat model of hemorrhagic shock. Surgery. 2006 Oct;140(4):579-87.
17. Campbell JE, Garrison RN, Zakaria ER. Clinical peritoneal dialysis solutions modulate white blood cell-intestinal vascular endothelium interaction. Am J Surg. 2006 Nov;192(5):610-6.
18. Zakaria ER, Ehringer WD, Nina T, Na Li, Garrison R.N. Direct energy delivery improves tissue perfusion after resuscitated shock. Surgery, 2005 (138)195-203.
19. Zakaria ER, Michelle C. Hunt, Harris PD, Garrison RN. Disparity in Osmolarity-induced Vascular Reactivity. J Am SocNephrol 2005; Oct;16 (10):2931-40.
20. Zakaria ER, R. N. Garrison, T. Kawabe, and P. D. Harris. Direct peritoneal resuscitation from hemorrhagic shock: effect of time delay in therapy initiation. J.Trauma 2005, 58 (3):499-506.
21. N. Li, Harris PD, Zakaria ER, Matheson PJ, Garrison RN. Microvascular responses to adenosine help explain functional and pathologic differences between intestinal segments. Am.J.Surg 2004, 188 (5):526-531.
22. Zakaria ER, Garrison RN, Spain DA, Harris PD. Impairment of endothelium dependent dilation response after resuscitation from hemorrhagic shock involved post-receptor mechanisms. Shock 2004, 21(2) 175-181.
23. Zakaria ER, Garrison RN, Kawabe T, Harris PD. Role of neutrophils on shock/resuscitation-induced intestinal arteriolar derangements. Shock 2004, 21(3):248-53.
24. Garrison RN, Adam A. Conn, Patrick D. Harris, Zakaria ER. Direct Peritoneal Resuscitation as Adjunct to Conventional Resuscitation from Hemorrhagic Shock: A Better Outcome.
25. Kawabe, T, Zakaria ER,Harris PD, Garrison RN: Peritoneal dialysis solutions contract large arteries through endothelium-independent prostanoid pathways. AdvPerit Dial (20): 177-183, 2004.
26. Zakaria ER, R. T. Hurt, P. J. Matheson, and R. N. Garrison. A novel method of peritoneal resuscitation improves organ perfusion after hemorrhagic shock. Am J Surg, 2003; 186 (5):443-448
27. Zakaria ER, Garrison RN, Spain DA, Matheson PJ, Harris PD, Richardson DJ. Intraperitoneal resuscitation improves intestinal blood flow following hemorrhagic shock. Ann Surg 2003, 237(5):704-713
28. Kawabe T, Harris PD, Zakaria ER, and Garrison RN. Sepsis alters vessel contraction by adrenoreceptor-induced nitric oxide and prostanoid. J Surg Res. 2003, 110 (2):352-359
29. Zakaria ER, Spain DA, Harris PD, Garrison RN: Generalized dilation of the visceral microvasculature by peritoneal dialysis solutions. Perit Dial Int 2002 22:593
30. Zakaria ER, Spain DA, Harris PD, Garrison RN: Resuscitation regimens for hemorrhagic shock must contain blood. Shock 2002, 18:567
31. Flessner MF Lofthouse J, Zakaria ER. Improving contact area between the peritoneum and intraperitoneal therapeutic solutions. J Am SocNephrol 2001, 12:807-813
32. Zakaria ER, Lofthouse J, Flessner MF. The effects of intraperitoneal pressures on tissue water of the abdominal muscle. Am J Physiol. 2000, 278:F875-F885
33. Zakaria ER, Lofthouse J, Flessner MF. In vivo Effects of hydrostatic pressure on the interstitium of abdominal wall muscle. Am J Physiol 1999, 279: H517-H529
34. Zakaria ER,Lofthouse J, Flessner MF. Intraperitoneal pressures modulate partitioning of total tissue water during peritoneal dialysis. Perit Dial Int 1999, Suppl. 2, S208-211
35. Zakaria ER, Lofthouse J, Flessner MF. In vivo Hydraulic conductivity of muscle: effects of hydrostatic pressure. Am. J. Physiol. 1997, 273:H2774-H2782
36. Flessner MF, Lofthouse J, Zakaria ER. In vivo diffusion of immunoglobulin G in muscle: effects of binding, solute exclusion, and lymphatic removal. Am. J. Physiol. 1997, 273:H2783-2793
37. Zakaria ER,Carlsson O, Rippe B. Limitation of small solute exchange across the visceral peritoneum: Effects of vibration. Perit Dial Int 1997, 17, 72-97
38. Zakaria ER,Simonsen O, Rippe A, Rippe B. Transport of tracer albumin from peritoneum to plasma: role of diaphragmatic, visceral, and parietal lymphatics. Am J Physiol 1996, 270 (Heart CircPhysiol 39) H1549-H1556
39. Zakaria ER,Carlsson O, Sjunnesson H, Rippe B. Liver is not essential for solute transport during peritoneal dialysis. Kidney Int 1996, 50: 298-303
40. Rippe B, Zakaria ER,Carlsson O. Theoretical analysis of osmotic agents in peritoneal dialysis. What size is an ideal osmotic agent? Perit Dial Int 1996, 16 (Suppl 1) S97-S103,
41. Carlsson O, Nielson S, Zakaria ER,Rippe B. In vivo inhibition of transcellular water channels (Aquaporin-CHIP) during acute peritoneal dialysis in rats. Am J Physiol 1996, 271 (Heart CircPhysiol 40): H2254-2262,
42. Zakaria ER,Rippe B. Peritoneal fluid and tracer albumin kinetics in the rat. Effects of increases in intraperitoneal hydrostatic pressure. Perit Dial Int 1995, 15:118-128
43. Zakaria ER, Rippe B. Intraperitoneal fluid volume changes during peritoneal dialysis in the rat. Indicator dilution vs. volumetric measurements. Blood Purif 1995, 13: 355-270
44. Osman A, Hakim JG, Lüneborg-Nilsen M, Bentzon MW, Ageel AM, Zakaria ER, Saleem A, Bakdash I. Comparative skin testing with PPD tuberculin, Mycobacterium Avium and M. Scrofulaceumsensitens in school children in Saudi Arabia. Tuber Lung Dis 1994, 75: 38-43
45. Zakaria ER, Rippe B. Osmotic barrier properties of the rat peritoneal membrane. ActaPhysiolScand 1993, 149: 355-364
46. 46. Rippe B, Zakaria ER. Lymphatic versus non lymphatic fluid absorption from the peritoneal cavity as related to the peritoneal ultrafiltration capacity and sieving properties. Blood Purif 1992, 10: 189-202.
Books, Chapters and Reviews
1. Zakaria ER, Mays CJ, Matheson PJ, Hurt RT, Garrison RN. Plasma appearance rate of intraperitoneal macromolecular tracer underestimates peritoneal lymph flow. In AdvPeritDial edited by Ramesh Khanna, 24, 16-21, Columbia University Press, Columbia, MO, 2008.
2. Zakaria ER, Matheson PJ, Hurt RT, Garrison RN. Chronic infusion of sterile peritoneal dialysis solution abrogates endothelial peritoneal gene expression responses to peritoneal catheter presence. In AdvPeritDial edited by Ramesh Khanna 24: 7-15, Columbia University Press, Columbia, MO, 2008.
3. Kawabe, T, Zakaria ER, Harris PD, Garrison RN: Peritoneal dialysis solutions contract large arteries through endothelium-independent prostanoid pathways. In AdvPeritDial edited by Ramesh Khanna (20): 177-183, Columbia University Press, Columbia, MO 2004.
4. Zakaria ER. Fluid and solute transport into and out of the peritoneal cavity: Experimental studies in the rat. Lund, Sweden. 1-72, Lund University Press, 1995.
1. Zakaria ER, Al-Thani A, Fadl T, Al-Thani M. Age is independent risk factor for endothelial cell dysfunction in chronic PD models in rats. Perit Dial Int 35, Suppl 1, S5. 2015.
2. Zakaria ER, Mays CJ, Matheson PJ, Hurt RT, Garrison RN. Plasma appearance rate of intraperitoneal macromolecular tracer underestimates peritoneal lymph flow. Perit Dial Int 2008, 28 (Suppl 1): S7.
3. Zakaria ER, Matheson PJ, Hurt RT, Garrison RN. Chronic infusion of sterile peritoneal dialysis solution abrogates endothelial peritoneal gene expression responses to peritoneal catheter presence. Perit Dial Int 2008: 28 (Suppl 1), S7.
4. Brandon CC, Ryan TH, Matheson PJ, Garrison RN, Zakaria ER. Cardiovascular and blood chemistry responses in a model of acute brain death in rats. AcadSurg Abstract Book, CA 2008.
5. Chester JM, Matheson PJ, Hurt RT. Zakaria ER. Mesenteric lymph flow rates and composition during resuscitated hemorrhagic shock. AcadSurg Abstract Book, CA 2008.
6. Campbell JE, Garrison RN, Zakaria ER. Modulation of the hemorrhage-induced pro-inflammatory endothelial phenotype by peritoneal resuscitation. AcadSurg Abstract Book, CA 2008.
7. Zakaria ER, Patel AM, Matheson PJ, Garrison RN. Vasoactive components of dialysis solution. Annual Dialysis Conference, Perit Dial Int 27:Suppl 1, S12, Denver CO, February 2007.
8. Zakaria ER, Patel AM, Matheson PJ, Garrison RN. Aquaporins modulate the exchange capillary surface area during peritoneal dialysis. Annual Dialysis Conference, Peritoneal Dialysis Int Vol 27:Suppl 1, S12, Denver CO, February 2007.
9. J.E. Campbell, R.N. Garrison, J.C. Peyton, E.R. Zakaria. Endothelial cell dysfunction and not blood rheology determines tissue myeloperoxidase activity after resuscitation from hemorrhagic shock. J Surg Res Volume 137, Issue 2, Page 336 (February 2007).
10. Matheson PJ, Harris BT, Hurt RT, Zakaria ER, Garrison RN. Enteral Supplementation But Not Intravenous Infusion of L-Glutamine Decreased Blood Flow in the Proximal Small Intestine, Pancreas and Spleen in Rats. 31st Annual Meeting of the Association of VA Surgeons, Little Rock, AR May 10-12, 2007.
11. Hurt RT, Matheson PJ, Mays CJ, Zakaria ER, McClave SR, Garrison RN: Early feeding in acute pancreatitis in rats. Gastroenterology 132(4) Suppl 2:A252, 2007.
12. Matheson PJ, Hurt RT, Zakaria ER, Garrison RN: Adrenomedullin blockade increases mortality and impairsblood flow during acute E. coli bacteremia in the rat. Shock Suppl, 27:53, 2007.
13. Zakaria ER, Campbell JE, Peyton JC, Garrison RN: Endothelial cell dysfunction and not blood rheology determines tissue myeloperoxidase activity after resuscitation from hemorrhagic shock. AcadSurg Congress, SUS & AAS JSR Suppl (#P262) 2007.
14. Li N, Harris PD, Matheson PJ, Zakaria ER, Garrison RN: Active absorption is required for glucose-induced vasodilation in the rat intestine. AcadSurg Congress, SUS & AAS, JSR Suppl (#P48) 2007.
15. Zakaria ER, Li N, Patel AM, Garrison RN. Molecular mechanisms of peritoneal dialysis solution-mediated vasodilation. PDI, Suppl 1(26) S7,2006.
16. Zakaria ER, Hurt RT, Matheson PJ, Garrison RN: PD prevents organ injury and improves survival from trauma and hemorrhagic shock. San Francisco, CA; Annual Dialysis Conference, Peritoneal Dialysis IntVol:page, Feb 26-28, 2006.
17. Tsakadge N, Zakaria RE, Matheson PJ, Garrison RN: Mechanism of adrenomedullin (AM)–mediated vasodilation in rat ileum. Academic Surgical Congress. San Diego, CA. Feb 7-11, 2006.
18. Li N, Harris PD, Zakaria ER,Matheson PJ, Garrison RN: Active transport is required for glucose-related vasodilation in intestine. Academic Surgical Conference, AAS & SUS, 2006.
19. ER Zakaria, AM Patel, RN Garrison. Molecular mechanisms of peritoneal dialysis solution-mediated vasodilation. Perit Dial Int, 2006.
20. Li N, Zakaria ER, Garrison RN: Direct intraperitoneal resuscitation reversed (DPR) intestinal microvascular impairment and hypoperfusion following hemorrhagic shock. Shock Suppl, 2006.
21. Li N, Harris PD, Zakaria ER,Matheson PJ, Garrison, RN: Inhibition of glucose transporter SGLT-1 attenuates glucose-induced dilation of intestinal microvessels. FASEB J. 19:A1245 (#688.16) 2005.
22. Matheson PJ, Tsakadze N, Zakaria ER, Garrison RN: Hypertonic saline (HTS) resuscitation (RES) improves intestinal micro-circulation after hemorrhagic shock (HS). Surgical Forum JACOS Suppl 2005.
23. Tsakadge N, Zakaria ER, Matheson PJ, Garrison RN: Mechanism of adrenomedullin (AM) – mediated vasodilation in rat ileum. Academic Surgical Congress. AAS & SUS #473, p333, 2006.
24. Li N, Harris PD, Zakaria ER, and Matheson PJ, Garrison, RN: Glucose-induced vasodilation of the jejunal vessels is mediated by the A1 adenosine receptor. FASEB J 19:A1245 (#688.17) 2005.
25. Li N, Harris PD, Zakaria ER, Matheson PJ, Garrison, RN: Nitric oxide partially mediates A1 adenosine receptor-mediated vasodilation during glucose absorption. FASEB J. 19:A1246 (688.18) 2005.
26. Matheson PJ, Tsakadze N, Zakaria ER, Garrison RN: Hypertonic saline (HTS) resuscitation (RES) improves intestinal microcirculation after hemorrhagic shock (HS). Surgical Forum JACOS Supply 2005.
27. RN Garrison, AA Conn, PD Hariris, ER Zakaria. Direct peritoneal resuscitation as adjunct to conventional resuscitation. A better outcome. Central Surgical Association. Surgery-St Louis, 2004 - St. Louis, CV Mosby Co.
28. Hurt RT, Zakaria ER, Matheson PJ, Garrison RN. A novel method of peritoneal resuscitation improves organ perfusion after hemorrhagic shock. Abstract #8, 27th Annual Surgical Symposium of the Association of VA Surgeons, Nashville, TN, May 3-5, 2003.
29. Zakaria ER, Hurt RT, Matheson PJ, Garrison RN. Peritoneal dialysis prevents organ injury and improves survival from trauma and hemorrhagic shock. PDI, Suppl 1(26) S7, 2006.
30. Tsakadze N, Zakaria ER, Matheson PJ, Garrison RN. Mechanisms of adrenomedulin (AM)-mediated vasodilation in rat ileum. AAS & SUS #473, p333, 2006.
31. Zakaria ER, Kawabe, T, Harris PD, Garrison RN: Peritoneal dialysis solutions contract large arteries through endothelium-independent prostanoid pathways. Perit Dial Int 24, Suppl 1, S12, 2004.
32. N Li, PD Harris, ER Zakaria, PJ Matheson, RN Garrison. A Microvascular response to adenosine varies with intestinal segment. Association of VA Surg, 2004.
33. Zakaria ER, Garrison RN: The peritoneum as a route for resuscitation from hemorrhagic shock. Amsterdam; Holland Peritoneal Dialysis Int. 24:511, 2004 (940).
34. Zakaria ER, Hunt MC, Li Na, Harris PD, Garrison RN: On the disparity in osmolarity-induced vascular reactivity. Amsterdam Holland; Peritoneal Dialysis Int 24:511,2004(#940)
35. Zakaria ER, Garrison RN, Harris PD: Role of neutrophils on shock/resuscitation-induced intestinal microvascular derangement. Shock Suppl 15 #6:A80 (#216) 2003
36. Zakaria ER, Spain DA, Harris PD, Garrison RN. Altered Receptor activity causes microvascular dysfunction after resuscitated hemorrhagic shock. Shock, 2002.
37. Zakaria ER, Spain DA, Harris PD, Garrison RN: Altered receptor activity causes microvascular dysfunction afterresuscitated hemorrhagic shock. Shock Suppl, 2002.
38. Zakaria ER, Spain DA: Regimens of resuscitation from hemorrhagic shock must contain blood. Shock, 2001.
39. Zakaria ER, Spain DA, Harris PD, Garrison RN. The Paradox: Peritoneal dialysis, A Novel Treatment in Hemorrhagic Shock. Perit Dial Int 21(Suppl. 1), S21, 2001.
40. Zakaria ER, Spain DA, Harris PD, Garrison RN. In vivo quantitative description of visceral microvascular reactivity in peritoneal dialysis. Perit Dial Int 21 (Suppl. 1), S21, 2001
41. Flessner, MF, Zakaria ER,Lofthouse J: Convective transport of immunoglobulin G through muscle interstitium. Faseb J 14: A25, 2000.
42. Zakaria ER,Lofthouse J, Flessner MF. Improving dialysis: Can peritoneal surface area be enhanced. J Am SocNephrol 1999.
43. ER Zakaria, J Lofthouse, MF Flessner. Contribution of Experimental Models in Peritoneal Dialysis Research-Hydrostatic and Osmotic Effects. Peritoneal Dialysis International, 1999 - New York: Pergamon Press, c1988.
44. Zakaria ER, Lofthouse J, Flessner MF. In vivo effects of hydrostatic and osmotic pressures on the interstitium of muscle. Faseb J. 12:A28, 1998.
45. Zakaria ER,Lofthouse J, Flessner MF. Intraperitoneal pressures modulate partitioning of total water content in peritoneal tissue. J Am SocNephrol 9:195A, 1998.
46. Zakaria ER, Lofthouse J, Flessner MF. Hydrostatic and osmotic pressures modulate partitioning of tissue water in the abdominal muscle during dialysis. Perit Dial Int 18 (Suppl. 2): S66, 1998.
47. Zakaria ER, J Lofthouse, MF Flessner. Effect of hydrostatic pressure on the interstitial space of muscle. Microcirculation, 1997.
48. Zakaria ER, Lofthouse J, Flessner MF. Fluid loss from the peritoneal cavity is dependent on dilution and washout of the interstitial matrix. J Am SocNephrol 8:294A, 1997.
49. Zakaria ER,Lofthouse J, Flessner MF. Effect of hydrostatic pressure on the interstitial space of muscle. Microcirculation 4:154, 1997.
50. Simonsen O, Zakaria ER, Rippe B. Absorption of labeled red cells and tracer albumin (RISA) from the peritoneal cavity to the blood. Role of diaphragmatic, visceral and parietal lymphatic pathways. EDTA abstract book. 1993.
51. Zakaria ER,Carlsson O. Do visceral stagnant fluid films limit the peritoneal exchange of small solutes? Perit Dial Int 1996; 16(Suppl 2): S11.
52. Simonsen O, Zakaria ER,Rippe B. Enhanced transperitoneal small solute exchange during the early portion of the dwell in CAPD patients. Role of the interstitium. Perit Dial Int, Abstract Seattle 1995.
53. Zakaria ER.Rippe B. Validation of the single injection RISA indicator dilution method for assessing intrperitoneal volume as a function of dwell time during peritoneal dialysis in the rat. In (ed) Abstract book of Scandinavian Society of Nephrology (Nordisk Nyredage), Reykjavik, Iceland, 1993; pp 29.
54. Rippe B. Zakaria ER. Peritoneal fluid and albumin kinetics in the rat: effects of increase in intraperitoneal hydrostatic pressure. Perit Dial Int 1993; 13(Suppl 1): S 74.
Clinical Assistant Professor
Department of Orthopedic Surgery and Emergency Medicine
Division of Anatomical Sciences
Department of Surgery
School of Medicine, University of Michigan
• (1971) BSc Saint Marys College-Moraga, California, USA
• (1972-1980) MD-PhD University of California at Los Angeles (UCLA)
• (2008-Present) University of Michigan-School of Medicine
• Senior Lecturer Division of Anatomical Sciences-Department of Surgery
• Course Chairman: M4 Senior Electives
• Course Chairman: Simulation Center Workshops Suture Techniques/Wound Closure
• (2010-2012) Director M1 Musculoskeletal Sequence
• (2011) Faculty/Instructor: M2 Musculoskeletal Sequence Lectures
• (2011) M3 Physical Examination Workshops
• (2011) M4 Musculoskeletal Education/OSCE
• (2015) General Surgery Boot Camp
• (2015) Orthopedic Boot Camp
• (2010) Clinical Assistant Professor-Department of Emergency Medicine
• ( 2011) Clinical Assistant Professor-Department of Orthopedic Surgery
• (2015) Elected to the Academy of Medical Scholars
• (2006-2015) Associate Editor Journal of the American Medical Association (JAMA)
• (2010-2014) Editorial Board Journal of Clinical Anatomy
• Peer Reviewer for British Medical Journal (BMJ)
• Peer Reviewer for Journal of Surgical and Radiologic Anatomy
His research interests include: Orthopaedic Surgery and General Orthopedic Surgery.
• Recipient of (2011) GalensSociety - Elizabeth Crosby Award for Teaching Excellence
• Recipient of (2012) GalensSociety - Elizabeth Crosby Award for Teaching Excellence
• Recipient of (2013) GalensSociety - Elizabeth Crosby Award for Teaching Excellence
• Recipient of (2012) Senior Award - Recognition by the Graduating Class for Outstanding Faculty within the School of Medicine
• Recipient 0f (2013) Senior Award - Recognition by Graduating Class for Outstanding Faculty within the School of Medicine
• Recipient of (2012) Thomas G. Varbedian Award for Excellence in Service to Medical Students
• Finalist for (2010) Kaiser Permanente Award for Excellence in Teaching
• Finalist for (2011) Kaiser Permanente Award for Excellence in Teaching
• Finalist for (2012) Kaiser Permanente Award for Excellence in Teaching
• Finalist for (2013) Kaiser Permanente Award for Excellence in Teaching
• Nominated for (2015) Kaiser Permanente Award for Excellence in Teaching
• TAM Awards (Token of Appreciation from Medical Students)
Given by graduating seniors at the University of Michigan Medical School (2010-2015)
• Designated as a Legendary Professor Code Blue University of Michigan (2011)
• American Medical Association (AMA) (1990-Present)
• American Association of Anatomists (AAA) (2002-Present)
• American Association of Clinical Anatomists (AACA) (2004-Present)
1. Shah V, Dooley-Hash S, Craig CL, Zeller JL. The value of m4 electives in promoting musculoskeletal education: a five-year institutional study creative education (CE). 2014; 521: 1905-1912.
2. Gadzinski A, Dimick J, Ye Z, Zeller J, Miller D. Transfer rates and utilization of post-acute care following surgery at Critical Access versus Non-Critical Access Hospitals. JAMA Surg. 2014; 149(7): 671-677. doi: 10.1001/jamasurg.2013.5694.
3. Watt T, Hariharan AR, Brzezinski DW, Caird MS, Zeller JL. Branching patterns and localization of the common fibular (peroneal) nerve: an anatomical basis for planning safe surgical approaches. Surg. Radiol. Anat. 2014. doi: 10.1007/s00276-013-1242-x
4. Bernstein J, Zeller JL, et al. Not the last word: free for service: the inadequate incentives for quality peer review. Clin. Orthop Relat Res (CORR). 2013.
5. Schubert M, Shah V, Craig CL, Zeller JL. Varied anatomy of the thumb pulley system: implications for successful trigger thumb release. J. Hand Surgery. 2012; 37A: 2278-2285. doi: 10.1016/j.jhsa.2012.08.005
6. Zeller JL. 28th Annual Meeting of the American Association of Clinical Anatomists (AACA). Journal of Clinical Anatomy. 2012; 24(8): 1016-1040.
7. Monrad SU, Zeller JL, Craig CL, DiPonio LA. Musculoskeletal education in us medical schools: lessons from the past and suggestions for the future. Curr Rev. Musculoskelet Med. 2011. doi: 10.1007/s12178-011-9083-x
8. Hiller AD, Miller JD, Zeller JL. Acromioclavicular Joint Cyst Formation. Clinical Anatomy. 2010; 23(2): 145-152. doi: 10.1002/ca.20918
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Department of Obstetrics and Gynecology
University of Florida, College of Medicine
Dr. Spiryda received a BA in Biochemistry with Honors from Barnard College, Columbia University and a PhD in Cell Biology and Anatomy/Biomedical Sciences and MD from Mount Sinai School of Medicine. She completed her residency in Obstetrics and Gynecology at Brigham and Women’s Hospital/Massachusetts Hospital Integrated Residency Program at Harvard University.
After 3 years of private practice in Rhinebeck, New York, Dr. Spiryda was recruited by University of South Carolina, School of Medicine through the Centenary Program to start-up and direct a translational research program on Biomarkers in Human Papillomavirus, Cervical dysplasia and cancer in 2007. She was an Assistant Professor in Obstetrics and Gynecology and held joint appointments in Women’s Studies Program and Pathology, Microbiology and Immunology departments. Dr. Spiryda served as Director of the Research Division and Resident/Student Research, and Director of Colposcopy.
In August 2013, Dr. Spiryda joined the faculty at University of Florida, College of Medicine in the Department of OB/GYN as an Associate Professor. She serves as Director of Resident Research, Director of Colposcopy, and Chair of the Residency Clinical Competency Committee. Dr. Spiryda directs the Translational Research Program in HPV and cervical dysplasia pursuing biomarkers involved with earlier detection of precancerous lesions and new treatment modalities for premalignant cervical disease. Dr. Spiryda has several ongoing clinical studies involving hysterectomy routes, breastfeeding, health disparities in women’s health including minimally invasive surgery techniques. She is currently a member of the Education Committee for the American Society of Colposcopy and Cervical Pathology (ASCCP).
In addition to her active translational and clinical research programs and teaching responsibilities, Dr. Spiryda has been a Board Certified OB/GYN since 2005 and maintains a large clinical practice encompassing the full spectrum of obstetrics and gynecology. Her special clinical interests include: minimally invasive surgical techniques (da Vinci robotic surgery, advanced laparoscopy and hysteroscopy), abnormal PAP tests, vulvar disease, adolescent gynecology, and family-oriented obstetrics. She belongs to the following professional societies: American College of Obstetrics and Gynecology, American Association of Gynecologic Laparoscopists, American Society of Colposcopy and Cervical Pathology and Association of Professors of Gynecology and Obstetrics.
Dr. Spiryda has published and presented nationally and internationally on a wide variety of topics in Women’s Health including: Trends in routes of Hysterectomy, Health disparities in minimally invasive surgery, HPV /cervical dysplasia/abnormal Pap tests and Health disparities in Breastfeeding, Obesity and Pregnancy outcomes and Graft versus Host disease in female genital organs and vulvar disease. She has mentored over 45 undergraduate, graduate, medical students, and resident physicians.
Dr. Spiryda has received multiple grants and awards for her research from local and national funding sources (USC, NIH, March of Dimes). She is currently the PI for a grant from National Institutes of Health/NCI/Center to Reduce Cancer Health Disparities, and was a co-investigator on a center grant from National Institutes of Health/National Center on Minority Health/ Health Disparities. In 2013, Dr. Spiryda received the American College of Obstetricians and Gynecologists/Hologic Research Fellowship in Cervical Cancer Detection.
Her research interests includes: Trends in Routes of Hysterectomy, Trends in Minimally Invasive Surgery (robotic surgery, hysteroscopy, advanced laparoscopy), Health disparities in Minimally Invasive Surgical techniques for hysterectomy, Molecular biomarkers (cell adhesion proteins, immune markers) and Human Papillomavirus, Cervical dysplasia and cancer, Health disparities in Women’s Health (breastfeeding, birth outcomes).
• April 2014 The George C. Trombetta, MD Teaching Award (ASCCP)
• (Mentor: LB Spiryda) Medical Students: Anna Handley (M Gywnne)
• Oral abstract presentation, “Outcomes of the Cervix Project: Increasing
Knowledge, Attitudes, and Practices of University of South Carolina
• Undergraduates Regarding HPV, Screening for HPV, and Vaccination against HPV”
• 2014 Biennial Meeting ASCCP Scottsdale, Arizona
• June 2014 Certificate of Recognition, Participation and Achievement in Medical Student Education for 2013 -2014, UF College of Medicine
MEMBERSHIP IN SCIENTIFIC ORGANIZATIONS
• Fellow, American College of Obstetrics and Gynecology
• Member, American Association of Gynecologic Laparoscopists
• Member, Association of Professors of Gynecology and Obstetrics
• Member, American Society for Colposcopy and Cervical Pathology
• Member, International Papillomavirus Society
• Member, Alachua County Medical Society
Original Research Articles
1. Spiryda LB. Do you know Mary? A story of Anorexia Nervosa and Bulimia. Barnard College Health Bulletin. 1989; 1(1): 2-3.
2. Beach MC, Morley J, Spiryda L, Weinstock SB. Effects of liposome encapsulated hemoglobin on the reticuloendothelial system. Biomater Artif Cells Immobilization Biotechnol. 1992; 20(2-4): 771-776.
3. Spiryda LB, Colman DR. Protein zero, a myelin IgCAM, induces physiologically operative tight junctions in nonadhesive carcinoma cells. J Neuro Res. 1998; 54(2): 282-288.
4. Spiryda LB, Colman DR. Suppression of tumorigenicity in an aggressive cervical carcinoma induced by protein zero, a nervous system IgCAM. J Cell Sci. 1998; 111(22): 3253-3560.
5. Spiryda LB. Induction of epithelialization and suppression of tumorigenicity in an aggressive carcinoma by protein zero, a nervous system IgCAM. Doctoral Dissertation MSSM UMI. 1998; 5.
6. Norwitz ER. Xu S, Xu J, et al. Direct binding of AP-1 (Fos/Jun) proteins to a SMAD binding element facilitates both gonadotropin-releasing hormone (GnRH) - and activin-mediated transcriptional activation of the mouse GnRH receptor gene. J Biol Chem. 2002; 277: 37469-37478.
7. Spiryda LB, Laufer MR, Soiffer RJ, Antin JA. Graft-Versus Host Disease of the Vulva and Vagina: Diagnosis and Treatment. Biology of Blood and Marrow Transplantation. 2003; 9(12): 760-766. doi: http://dx.doi.org/10.1016/j.bbmt.2003.08.001
8. Spiryda LB, Fuller AF, Goodman A. Aggressive Locally Recurrent Vulva Cancer: review of cases presented to Massachusetts General Hospital 1990 to present. Internl Jl of Gyneologic Oncology . 2005; 15(5): 884-889.
9. Spiryda LB, Brown M, Creek KE, Pirisi L. HSIL PAP test and risk factors predicting acquisition of CIN 2/3 on colposcopy-directed biopsies. J SCMA. 2009; 105(7): 281-289.
10. Wigfall L, Rawls A, Sebastian N, et al. HPV high risk and protective behaviors: The effects of religious affiliation. Journal of Religion and Health. 2011; 1-12. doi: 10.1007/s10943-010-9444-6
11. Boggs EW, Burgis JT, Spiryda LB. Keratinizing squamous dysplasia Pap test: A case for colposcopy. Journal of Lower Genital Tract Disease. 2012; 16(1): 30-33. doi: 10.1097/LGT.0b013e31822d3846
12. Banister CE, Messersmith AR, Chakroborty H, et al. HPV prevalence at enrollment and baseline results from the Carolina Womens Care Study, a longitudinal study of HPV persistence in college-age women. International J Womens Health. 2013; 5: 379-388. doi: http://dx.doi.org/10.2147/IJWH.S45590
13. Banister C, Messersmith AR, Spiryda LB, Glover S, Pirisi L, Creek KE. Increased risk of persistent human papillomavirus infection and abnormal Pap tests in African American compared to European American women in a college-age cohort. Journal of Infectious Disease. 2014.
14. Lenhard M, Zhang HM, Cao J, Spiryda LB. Factors Influencing the Decision to Breastfeed by Mothers in a Southern Womens Health Clinic. Womens Health, Issues and Care. 2014.
15. Emery J, Marcus BJ, Spiryda LB. Sarcoidosis of the cervix: an unusual case presentation. Genital System & Disorders. 2014. 16. McLeod JB, Cao J, Spiryda LB. Introduction of laparoscopic hysterectomy approach: decreasing the abdominal hysterectomy approach or replacing vaginal hysterectomy. Surg Res Open J. 2015; 2(1): 36-42. doi: 10.17140/SROJ-2-107
17. Kinson MS, Spiryda LB. Management of adnexal masses in children and adolescent populations: advocating for ovarian conservation. Surg Res Open J. 2015; 2(2): 72-76. doi: 10.17140/SROJ-2-113
18. Lipman M, Spiryda LB. The opportunistic salpingectomy in reducing ovarian cancer risk: Do the potential benefits outweigh complications? Surg Res Open J. 2016; 3(1): 20-23. doi: 10.17140/SROJ-3-118
Medical Director & Senior Consultant Surgeon
Department of Surgery & Surgical Oncology
Nexus Surgical Associates Pte Ltd
3 Mt Elizabeth, 08-06
Mt Elizabeth Medical Centre
Dr. Liau is an accredited surgeon with many years of experience in diagnosing and treating liver, gallbladder and pancreatic cancers and disorders. His other clinical expertise includes cancer surgery, gastrointestinal surgery, surgical infections, laparoscopic surgery and endoscopy. Dr. Liau graduated from the National University of Singapore in 1994 and obtained his postgraduate surgical degree in 1998. The same year, he was admitted to the Fellowship of the Royal College of Surgeons of Edinburgh, UK. Subsequently, he received his further training in cancer management at Memorial Sloan Kettering Cancer Centre, New York, USA in 2002. When he returned to Singapore in 2003, he was conferred Fellowships by Academy of Medicine (Singapore) and International College of Surgeons (USA).
Prior to establishing his private practice, Dr. Liau was the Chief of Hepatobiliary and Pancreatic Surgery Unit in the Department of General Surgery from 2004 to 2010. He was the Deputy Head of Department of General Surgery, Tan Tock Seng Hospital from 2008 to 2010 and council member of Asian-Pacific Hepato-Pancreato-Biliary Association from 2005 - 2011. Currently, Dr. Liau serves in the council of the College of Surgeons, Singapore and is a member of the Society for Surgery of Alimentary Tract (SSAT) and International Hepato-Pancreato-Biliary Association (IHPBA). Dr. Liau has a keen interest in the care of patients with neuroendocrine tumours (carcinoids) and he serves in the executive committee of the Carcinoid & Neuroendocrine Tumor Society (CNETs).
Beneath the youthful and cheerful disposition which Dr. Liau is commonly known to his patients, he is a professional, confident and efficient surgeon who has a proven clinical track records. Dr. Liau, an ASEAN Scholarship awardee, was the recipient of the 2008 and 2009 Star Excellent Service Awards. In 2009, the Singapore Public Service honoured Dr. Liau with PS21 Star Service Award for having gone beyond the call of duty to deliver excellent service to his patients. In recognition to his service to Emirate patients, he was also presented with the Embassy of United Arab Emirates Medal.
His research interests include: Cancer surgery, Gastrointestinal surgery, Hernia surgery, Laparoscopic surgery and endoscopy.
HONOURS AND AWARDS
ACADEMIC & QUALITY AWARDS
YEAR AWARD & SCHOLARSHIP
• (1987) Asean Pre-U Scholarship by Public Service Commission, Singapore
• (1988) Distinction Award by Hwa Chong Junior College, Singapore
• (1989) Medical Undergraduate Sponsorship by Loke Foundation, Singapore
• (1998) HMDP Postgraduate Scholarship in Surgery
• (2002) Tan Tock Seng Hospital Overseas Clinical Fellowship Scholarship
• (2006) Staff Development Programme Award (Czech Republic)
• (2006) TTSH Outstanding Project Award
• (2006) NHG CPIP Best Project Award On Clinical Quality Improvement
• (2007) SMJ Reviewer Recognition Award (Reviewing with Distinction)
• (2007) TTSH Best Clinical Quality Poster Award
• (2007) Staff Development Programme Award (Spain)
• (2008) Staff Development Programme Award (France)
• (2008) Asian Hospital Management Excellence Award Department Service Improvement Category
• (2008) NHG Annual Scientific Meeting Congress Merit Award
• (2008) 5th MOH Healthcare Quality Poster Competition Award - First Prize
• (2009) 6th MOH Healthcare Quality Poster Competition Award - Merit Prize
• (2009) TTSH Best Quality Improvement Award - Merit Award
• (2009) 9th NHG Quality Week Poster Competition - Merit Award
• (2000) Quality Pillar Award by National Health Group, Singapore
• (2001) Long Service Award 5 Years by Tan Tock Seng Hospital
• (2004) Service Champion Award
• (2005) Spring Singapore EXSA Award 2005-Silver
• (2006) Long Service Award 10 Years by Tan Tock Seng Hospital
• (2006) Spring Singapore EXSA Award 2006-Gold
• (2008) Spring Singapore EXSA Award 2008-Star Award
• (2008) Spring Singapore EXSA Superstar Finalist Nominee
• (2009) PS21 Star Service Award (Healthcare)
• (2009) Spring Singapore EXSA Award 2009 -Star Award
PRINCIPLE INVESTIGATOR AWARDS
• (2004) A*Star Cancer Research Fund Award
• (2005) Singapore Cancer Syndicate Research in Liver Cancer
• (2005) MOH Health Quality Improvement Fund Award (Surgical Site Infection)
• (2008) MOH Health Quality Improvement Fund Award (Hypothermia)
• (2009) MOH Health Quality Improvement Fund Award (POSSUM)
• (2010) JnJ Ethicon Surgical Research Grant Award
Local Professional Society Membership Year
• Singapore Medical Association Member (1994-Present)
• Medical Alumni Association of Singapore Member (1994-Present)
• Singapore Society of Oncology Member (2001-Present)
• Gastroenterological Society of Singapore Member (2001-Present)
• Academy of Medicine Singapore Fellow (2003-Present)
• College of Surgeons, Singapore Fellow (2005-Present)
• College of Surgeons, Singapore Council (2010-Present)
• Carcinoid & Neuroendocrine Tumour Society Secretary (2010-2012)
• Carcinoid & Neuroendocrine Tumour Society Treasurer (2013-Present)
• Hepato-Pancreato-Biliary Association (Spore) Founder (2012)
• Hepato-Pancreato-Biliary Association (Spore) V/President(2012 -2014)
Regional Professional Society Membership Year
• Endoscopic & Laparoscopic Surgeons of Asia Member (2003-Present)
• Asian-Pacific Hepato-Pancreato-Biliary Assn Founder (2004-Present)
• Asian-Pacific Hepato-Pancreato-Biliary Assn Council (2004-20 09)
• Coalition to Eradicate Viral Hepatitis in AsiaPacific Member (2013-present)
International Professional Society Membership Year
• Royal College of Surgeons, Edinburgh, UK Fellow (1999-Present)
• International College of Surgeons, Chicago Fellow (2002-Present)
• International Hepato-Pancreato-Biliary Association Member (2002-Present)
• New York Academy of Sciences, USA Member (2003-Present)
• Memorial Sloan-Kettering Cancer Center Alumni Member (2003-Present)
• The Society for Surgery of the Alimentary Tract Member (2004-Present)
• The Carcinoid Cancer Foundation Doctor (2012 - Present)
• European Neuroendocrine Tumours Society Member (2012-Present)
• Global Neuroendocrine Tumour Alliance Council (2010 - 12)
• International Neuroendocrine Cancer Alliance Founder (2013)
• International Neuroendocrine Cancer Alliance Council (2013-Present)
• International Surgical Infections Study Group Member (2013-Present)
1. Lai TC, Cheng CW, Fen CM, et al. Public Health Education Concerning Your Health. Singapore Medical Association Webpage, Concerning Your Health. 2000.
2. Kwang LC, Hin LK, Chew W. Results of Distal Radial Fractures Treated by Intra-focal Pin Fixation Annals. Academy of Medicine, Singapore.2001; 30(6): 573-576.
3. Tong HC, Hin LK, Ho Choon Kiat, Ping CS. Hepatolithiasis: A Case Series Annals. Academy of Medicine, Singapore. 2002; 30(1): 97-101.
4. Yip CC, Hin LK, Kiat, Ping CS. Mirizzis Syndrome: A Diagnostic and Operative Challenge. Journal RCS Edinburgh & Ireland. 2003; 1(5): 273-278.
5. Hin LK, Paul DR. Fresh Frozen Plasma Use in Liver Resection. Journal of the American College of Surgeons. 2003; 197(4): 700-701.
6. Hin LK, Paul DR, Blumgart LH. Segment-oriented Approach to Liver Resection. Surgical Clinics of North America. 2004; 84(2): 543-561. doi: 10.1016/j.suc.2003.12.003
7. Liau KH, Ruo L, Shia J, et al. Outcome of Partial Hepatectomy for Large (>10 cm) HepatocellularCarcinoma. Cancer.2005; 104(9): 1948-1955. doi: 10.1002/cncr.21415
8. F Stipa, SS Yoon, Liau KH, et al. Outcome of patients with fibrolamellar hepatocellular carcinoma. Cancer. 2006; 106(6): 1331-1338. doi: 10.1002/cncr.21703
9. Tadahiro T, Yoshifumi K, Yuji N, et al. Background: Tokyo Guidelines for the management of acute cholangitis and cholecystitis. Journal Hepatobiliary Pancreatic Surgery. 2007; 14(1): 1-10. doi: 10.1007/s00534-006-1150-0
10. Miho S, Tadahiro T, Yoshifumi K, et al. Need for criteria for the diagnosis and severity assessment of acute cholangitis and cholecystitis: Tokyo Guidelines. Journal Hepatobiliary Pancreatic Surgery. 2007; 14(1): 11-14.
11. Fumihiko M, Tadahiro T, Yoshifumi K, et al. Flowcharts for the diagnosis and treatment of acute cholangitis and cholecystitis: Tokyo Guidelines. Journal Hepatobiliary Pancreatic Surgery. 2007; 14(1): 27-34.
12. Toshio T, Tadahiro T, Yoshifumi K, et al. Techniques of biliary drainage for acute cholangitis: Tokyo Guidelines.Journal Hepatobiliary Pancreatic Surgery. 2007; 14(1): 35-45. doi: 10.1007/s00534-006-1154-9
13. Keita W, Tadahiro T, Yoshifumi K, et al. Diagnostic criteria and severity assessment of acute cholangitis. Journal Hepatobiliary Pancreatic Surgery. 2007; 14(1): 52-58. doi: 10.1007/s00534-006-1156-7
14. Atsushi T, Tadahiro T, Yoshifumi K, et al. Antimicrobial therapy for acute cholangitis: Tokyo Guidelines.Journal Hepatobiliary Pancreatic Surgery. 2007; 14(1): 83-90. doi: 10.1007/s00534-006-1160-y
15. Masato N, Tadahiro T, Yoshifumi K, et al. Methods and timing of biliary drainage for acute cholangitis. Journal Hepatobiliary Pancreatic Surgery. 2007; 14(1): 68-77.
16. Keita W, Kawarada K, Yoshifumi K, et al. Diagnostic criteria and severity assessment of acute cholecystitis. Journal Hepatobiliary Pancreatic Surgery. 2007; 14(1): 78-82. doi: 10.1007/s00534-006-1159-4
17. Yuichi Y, Tadahiro T, Yoshifumi K, et al. Surgical treatment of patients with acute cholecystitis. Journal Hepatobiliary Pancreat Surgery. 2007; 14(1): 91-97. doi: 10.1007/s00534-006-1161-x
18. DeMatteo RP, Gold JS, Saran L, et al. Tumour mitotic rate, size, and location independently predict recurrence after resection of primary gastrointestinal stromal tumour.Cancer. 2007. doi: 10.1002/cncr.23199
19. Kow A, Chan CY, Earnest A, et al. Striving for A Better operative Outcome: 101 Pancreatic oduodenectomies. HPB (Oxford). 2008; 10(6): 464-471. doi: 10.1080/13651820802247094
20. Shelat VG, Chan CY, Liau KH. Education and imaging. Hepatobiliary and pancreatic: operative bile duct injury. Journal of Gastroenterology and Hepatology. 2008; 23: 1461. doi: 10.1111/j.1440-1746.2008.05587.x
21. Kow A, Chan CY, Earnest A, et al. A Audit of Ambulatory Laparoscopic Cholecystectomy in a Singapore Institution: Are We Ready for Day-Case Laparoscopic Cholecystectomy? HPB (Oxford). 2008; 10(6): 433-438. doi: 10.1080/13651820802392312.
22. De SD, Chieh KW, Liau KH, et al. Novel Approach to Laparoscopic Resection of Tumours of Distal Pancreas. ANZ J Surg. 2009; 79(4): 288-293. doi: 10.1111/j.1445-2197.2009.04878.x
23. Katz SC, Shia J, Liau KH , et al. Operative Blood Loss predicts Recurrence and Survival Following resection of Hepatocellular Carcinoma Independent of Allogenic Transfusion. Ann Surg. 2009; 249(4): 617-623.
24. Ethene W, Alfred K, Chieh W, et al. Starting a Laparoscopic Hepatectomy Programme. Singapore Med J. 2009; 50(4): 354-359.
25. Kan TK, Kenneth C, Hin LK, Kiat HC. Pancreatic Tuberculosis Mimicking Pancreatic Carcinoma: Series of Three Cases. European journal of gastroenterology & hepatology. 2009. doi: 10.1097/MEG.0b013e32832bab73.
26. Ying NS, Stanley NG, Wan YY, et al. Ablation of Phosphoinositide-3-Kinases Class II Alpha Suppresses Hepatoma Cell Proliferation. Biochem Biophys Res Commun. 2009; 387(2): 310-315. doi: 10.1016/j.bbrc.2009.07.013
27. Hin LK, Khin TA, Chua N, Joo CS. Outcome of a Strategy in Reducing Surgical Site Infection in a Tertiary Tertiarycare Hospital. Surgical infections. 2010; 11(2): 151-159. doi: 10.1089/sur.2008.081
28. Huang M, Kwek JW, Hin LK, Vu C. Diagnosis and Management of Cystic Neoplasm of Pancreas. Singapore Medical Journal. 2010; 51(8): 668-675. doi: 10.2214/AJR.12.8862
29. Winson TJ, Sanghvi K, Hin LK, Hock LC. An Audit Study of the Sensitivity and Specificity of Ultrasound, Fine Needle Aspiration Cytology and Frozen Section in the Evaluation of Thyroid Malignancies in a Tertiary Institution.Annals of the Academy of Medicine, Singapore. 2010; 39(5): 359-362.
30. Kan TK, Girishchandra SV, Hin LK, et al. Laparoscopic common bile duct exploration: our first 50 cases.Annals of the Academy of Medicine, Singapore. 2010; 39(2): 136-142.
31. Kan TK, Zhiyan Y, Hin LK. Emergency Surgery for a Ruptured Intra-abdominal Desmoid Tumour. Annals of the Academy of Medicine, Singapore.2010; 39(6): 497-498.
32. Tan CH, Pua U, Hin LK, Lee HY. Mesenteric desmoid tumour masquerading as a fat-containing cystic mass. The British journal of radiology. 2010; 83(994): e200-e203.doi: 10.1259/bjr/68468861.
33. Hin LK, Tung AK. Reducing Surgical Site Infection in a Hospital in Singapore. Wounds International. 2001; 2(1): 9-13.
34. Alfred K, Bei W, Daniel W, et al. Using Percutaneous transhepatic Cholangioscopic Lithotripsy for Intrahepatic Calculus in Hostile. Abdomen Surgeon. 2011; 9(2): 88-94. doi: 10.1016/j.surge.2010.08.002
35. Tan Winton J, Alfred K, Hin LK. Moving towards the New International Study Group for Pancreatic Surgery (ISGPS) definitions in pancreaticoduodenectomy: a comparison between the old and new. HPB (Oxford). 2011; 13(8): 566-572.
36. Soh YF, Kow AW, Wong KY, et al. Perioperative Outcomes of Laparoscopic and Open Distal Pancreatectomy: our institutions 5-year experience.Surg. 2012; 35(1): 29-36. doi: 10.1016/j.asjsur.2012.04.005
37. Shelat VG, Chan CY, Hin LK, Ho CK. Laparoscopic Exploration Can Salvage Failed Endoscopic Bile Duct Stone Extraction. Singapore Med J. 2012; 53(5): 313-317.
38. Kow A, Sadayan NA, Ernest A, et al. Is Pancreaticoduodenectomy Justified In Elderly Patients? The Surgeons. 2012; 10(3): 128-136. doi: 10.1016/j.surge.2011.02.005
39. Kiriyama S, Takada T, Strasberg SM, et al. TG13 guidelines for diagnosis and severity grading of acute cholangitis(with videos). J Hepatobiliary Pancreat Sci. 2013; 20(1): 24-34. doi: 10.1007/s00534-012-0561-3.
40. Yokoe M, Takada T, Strasberg SM, et al. TG13 diagnostic criteria and severity grading of acute cholecystitis (with videos). J Hepatobiliary Pancreat Sci. 2013; 20(1): 35-46. doi: 10.1007/s00534-012-0568-9
41. Miura F, Takada T, Strasberg SM, et al. TG13 flowchart for the management of acute cholangitis andcholecystitis. J Hepatobiliary Pancreat Sci. 2013; 20(1): 47-54. doi: 10.1007/s00534-012-0563-1
42. Gomi H, Solomkin JS, Takada T, et al. TG13 antimicrobial therapy for acute cholangitis and cholecystitis. J Hepatobiliary Pancreat Sci. 2013; 20(1): 60-70. doi: 10.1007/s00534-012-0572-0
43. Chung AYF, Ooi LLPJ, Machin D, et al. Adjuvant Hepatic Intra-arterial Iodine-131-Lipiodol following curative resection of hepatocellular carcinoma: A prospective randomized trial and overview. World Journal of Surgery. 2013; 37(6): 1356-1361. doi: 10.1007/s00268-013-1970-4
44. Kurup A, Liau KH, Ren J, et al. Antibiotic management of complicated intra-abdominal infections in adults: The Asian perspective. Annals of Medicine and Surgery. 2014. doi: 10.1016/j.amsu.2014.06.005
45. Smith R1, Stain SC, McFadden DW, Finlayson SR, Jones DB. Will there be a good general surgeon when you need one? (Part II) Solutions and taking back general surgery. Public Policy & Advocacy Committee of the SSAT (Reid Lombardo KM, Auyang J Gastrointest Surg. 2014; 18(7): 1334-1342. doi: 10.1007/s11605-014-2522-4
46. Hin LK, Teh C and Serrablo A. Management of Acute Cholecystitis and Acute Cholangitis in Emergency Setting. Central European Journal of Medicine. 2014; 9(3): 357-369. doi: 10.2478/s1536-013-0301-3
Head and Senior Consultant
Division of Thoracic Surgery
Department of Cardiac, Thoracic, and Vascular Surgery
National University Health System
Dr. Tam is an accomplished thoracic surgeon who performs the full spectrum of thoracic surgery, including diseases in the lung, mediastinum, pleura, chest wall, and diaphragm. He is specialized in performing minimally invasive keyhole surgery using advanced Video-Assisted Thoracoscopic Surgery (VATS) techniques, and has pioneered new techniques in Uniportal VATS or Single Incision VATS to perform lung and chest surgeries. These techniques are well-liked by patients as they gain faster recovery and less pain after surgery. He performed the first Uniportal VATS lobectomy in the world in June 25, 2009. He currently runs a full Uniportal VATS program and has offered this surgery to more than 400 patients with excellent results.
Dr. Tam achieved the SPRING Singapore Excellent Service Gold Awards in 2008 and 2009 in recognition of his excellent service to patients. He achieved the NUS Faculty Teaching Excellence Award for 3 consecutive years from 2007 to 2010.
Dr. Tam is certified as a Fellow of the Royal College of Physicians and Surgeons of Canada (FRCSC). He previously worked and trained in the United States of America (USA) and Canada for nearly twenty years. He was Clinical Instructor at the Advance Minimally Invasive Thoracic Surgery Center at the University of Pittsburgh in USA. Prior to that, he obtained the Doctor of Medicine (M.D.) degree at the University of Alberta and underwent Thoracic Surgery training at the University of Manitoba in Canada. He holds the Master of Education degree, Master of Science degree, and Bachelor of Science degree in Biochemistry with First Class Honors from Canada.
His research interests include: Minimally Invasive Thoracic Surgery, Lung cancer, Pneumonthorax, Empyema, Medical Education, Surgical Education.
• 2010 Faculty Teaching Excellence Award, National University of Singapore
• 2009 Faculty Teaching Excellence Award, National University of Singapore
• 2008 Faculty Teaching Excellence Award, National University of Singapore National Excellent Service Gold Award
• 2003 Best clinical paper – American College of Surgeons, Manitoba Chapter, Canada
• 2003 First Prize Research Award
General Surgery & Thoracic Surgery Research Competition, University of Manitoba, Canada
• 1995 Dr. AJ Paul Bursary in Medicine - University of Alberta, Canada
• 1995 Deans Silver Medal in Science - University of Alberta, Canada
1. Tam JKC, Lim KS. Total muscle-sparing uniportal video-assisted thoracoscopic surgery
Lobectomy. Am Thorac Surg. 2013. doi: 10.1016/j.athoracsur.2013.07.002
2. Tran T, Teoh CM, Tam JKC, et al. Laminin Drives Survival Signals to Promote a Contractile Smooth Muscle Phenotype and Airway Hyperreactivity. FASEB J. 2013; 27(10): 3991-4003. doi: 10.1096/fj.12-221341
3. Tan SL, Ong B, Cheng C, et al. Anti-Malarial Drug Artesunate Inhibits Primary Human Cultured Airway Smooth Muscle Cell Proliferation. Am J Respir Cell Mol Biol. 2014. doi: 10.1165/rcmb.2013-0273OC
4. Tam JKC, Asmat A, Tan AK. Video assisted thoracic surgery (VATS) repair of subclavian artery injury following central venous catheterization: A new approach Interact. Cardiovasc Thorac Surg. 2013; 17(1): 13-15. doi: 10.1093/icvts/ivt109
5. Teoh CM, Tam JKC, Tran T. Ethical Issues in Using Bronchial Biopsies for Asthma Res. Asian Bioethics Rev. 2012; 9.
6. Teoh CM, Tam JKC, Tran T. Integrin and GPCR Crosstalk in the Regulation of ASM Contraction Signaling. Asthma J of Allergy. 2012; 4(3): 183-197.
7. Haniffa M, Shin A, Bigley V, et al. Human tissues contain CD141(hi) cross-presenting dendritic cells with functional homology to mouse CD103(+) nonlymphoid dendritic cells. Immunity. 2012; 37: 1-14. doi: 10.1016/j.immuni.2012.04.012.
8. Zhang WC, Ng SC, Yang H, et al. Glycine decarboxylase activity drives non‐small cell lung cancer tumorinitiating cells and tumorigenesis. Cell. 2012; 148: 1-14. doi: 10.1016/j.cell.2011.11.050
9. Khan M, Tam J. Role of chaperone mediated autophagy (CMA) in the degradation of misfolded N-CoR protein in non-small cell lung cancer (NSCLC) cells. PLoS ONE. 6(9): e25268.
10. Koh LP, Poon M, Tam J, Teo L, Hsu LY. Spontaneous pneumothorax in an allogeneic cell transplant recipient with invasive pulmonary aspergillosis and antecedent RSV pneumonitis. Mediterr J Hematol. Infect Dis. 2011; 2: e2011014. doi: 10.4084/MJHID.2011.0
11. Liao W, Goh FY, Betts RH, et al. A novel antiapoptotic role for apolipoprotein L2 in IFN-g-induced cytotoxicity in human bronchial epithelial cells. J. Cell Physiol. 2011; 226(2): 397-406. doi: 10.1002/jcp.22345
12. Asmat A, Tam J. Spontaneous Haemothorax from an Osteochondroma. Eur J Cardiothorac Surg. 2009; 36(2): 394. doi: 10.1016/j.ejcts.2009.04.039.
13. Zhou J, Chen H, Lu JJ, et al. Application of a modified McKeown procedure (thoracosopic esophageal mobilization three incision esophagectomy) in esophageal cancer surgery: Initial experice with 30 cases. Dis Esophagus. 2009; 22(8): 687-693. doi: 10.1111/j.1442-2050.2009.00963.x
14. Lim EH, Zhang SL, Li JL, et al. Using whole genome amplification (WGA) of low-volume biopsies. J Thorac Oncol. 2009; 4(1): 12. doi: 10.1097/JTO.0b013e3181913e28
15. Chen H, Lu JJ, Zhou J, et al. Anterior versus posterior routes of reconstruction after esophagectomy: a comparative anatomic study. Ann Thorac Surg. 2009; 87(2): 400. doi: 10.1016/j.athoracsur.2008.11.016
16. Tam J, Goh PS, Siow WY, Gopalakrishnakone P, Zubair A. Medical Education in a Flat World. Ann Acad Med Singapore. 2008; 37: 991.
17. Awais O, Luketich JD, Tam J, et al. Roux en Y near esophagojejunostomy for intractable gastroesophageal reflux after antireflux surgery. Ann Thorac Surg. 2008; 85(6): 1954. doi: 10.1016/j.athoracsur.2008.01.072
Department of Surgery
The University of Arizona
1501 N. Campbell Ave., Rm 4334B
Tucson, AZ 85724-5131, USA
Evan Ong, MD, MS, FACS, joined the department of surgery in July 2008 as an Assistant Professor of Surgery in the Section of Surgical Oncology. Dr. Ong grew up in the Upstate New York area, graduated with a BA and MA degree from Harvard University, and received his medical degree from the Albert Einstein College of Medicine in the Bronx, NY. He then matched his general surgery residency at the University of Illinois at Chicago-Cook County Program. During his surgical residency, Dr. Ong spent an additional 2 years as a postdoctoral research fellow in the Department of Pharmacology studying the molecular and cellular mechanisms of inflammation and completed a Master of Science degree. From there, Dr. Ong matched into a surgical oncology fellowship at the first cancer center of the United States, Roswell Park Cancer Institute in Buffalo, NY. After completing his fellowship, he was recruited to join the Surgical Oncology/ HPB Section at the University of Arizona. Dr. Ong is also the current Surgical Clerkship Director for the University of Arizona College of Medicine.
Dr. Ong’s clinical practice focuses on gastrointestinal cancers with particular interest in treatment options for regional and metastatic disease. He offers state-of-the-art technology such as laparoscopic liver resection, microwave and bipolar radiofrequency ablation as well as Hyperthermic Intraperitoneal Chemoperfusion (HIPEC), a treatment option for cancers that have disseminated to the peritoneal cavity.
Dr. Ong’s basic science research focuses on the development and progression of pancreatic cancer. Through his co-appointment in the Geriatrics department, Dr. Ong is currently developing a geriatric scoring system to predict surgical outcomes in the elderly patient.
Because of his clinical focus on patients with metastatic disease, Dr. Ong has become extremely active in the field of Hospice and Palliative Care both clinically and scientifically. Recently, Dr. Ong has become one of the very few surgeons in the United States to be Board Certified in the field of Hospice and Palliative Care.
His research interests include:
• Molecular and Cellular Mechanisms of Inflammation.
• Effect of Immune Modulation and Aging on the Development and Progression of Gastrointestinal Cancers.
• Geriatric Assessment System predicting Surgical Outcomes in the Elderly Patient.
• Treatment Effects of IPHC - Intraperitoneal Hyperthermic Chemoperfusion.
2002 Warren H. Cole Surgery Society, Associate Resident Member
2002 Association for Academic Surgery, Active Member
12th Annual Fundamentals of Surgical Research Course, 2001
2001 Sigma Xi Honors Scientific Research Society, Full Member
2004 AmericanCollege of Surgeons, Member
2004 The Harvard Club of Chicago, IL, Member
2006 Alpha Omega Alpha Honors Medical Society, Member
2007 Society of Surgical Oncology, Member
2007 American Society of Clinical Oncology, Associate Member
2007 The Harvard Club of Buffalo, NY, Member
2009 Tucson Surgical Society, Member
2009 Association for Surgical Education, Member
• Assessment and Evaluation Committee
2009 Arizona Chapter - American College of Surgeon, Member
2009 American Society of Peritoneal Surface Malignancies, Member
2009 Paraguayan Society of Medical Oncology, Member
2009 Paraguayan Society of Surgical Oncology, Member
2009 Southwest Oncology Group (SWOG), Member
• Gastrointestinal Cancer and Translational Medicine Committees, member
• Surgery Committee member
2009 American Hepato-Pancreato-Biliary Association, Member
2009 Southwestern Surgical Congress, Member
2009 - 2010 Society for Thermal Medicine
2010 International Hepato-Pancreato-Biliary Association, Member Committees
2008 ArizonaCancerCenter Oncology Clinical Operations Committee, AZCC
2008 Arizona Cancer Center Oncology Services Quality and Safety-based team, AZCC
2009 Champion for the “Pride in Action” (Studer) Physician Engagement Initiative,UMC
2009 Technology Assessment Committee, UPH
2009-2012 Admissions Committee (subcommittee C), College of Medicine, UA
2009-current Clinical Curriculum subcommittee, College of Medicine, UA
• Vice Chair 2012
• Chair 2013
2009-current MDS Graduate Program, Program committee, Dept. of Surgery, UA
2010-current Strategic Planning/Development committee, Dept. of Surgery, UA
2011-current Student Appeals Committee, College of Medicine, UA
• Chair 2012
2012-current Student Affairs Committee, College of Medicine, UA
1. Ong E. Neural Pathways of Acupuncture Analgesia. Harvard Brain. 1994; 1(1): 3-4.
2. Greenstein SM, Kim D, Principe A, et al. Renal transplantation in a heterogeneous population: the thirty- year Montefiore Medical Center experience. ClinTranspl. 1998; 187: 93.
3. Greenstein SM, Delrio M, Ong E, et al. Plasmapheresis treatment for recurrent focal sclerosis in pediatric renal allografts. PediatrNephrol. 2000; 14(12): 1061-1065. doi: 10.1007/s004670000378
4.Espat NJ, Ong E, Helton WS. Intra-operative Laparoscopic and Ultrasound Assessment of Resectability for Hepatic Resection. Operative Techniques in General Surgery. 2002; 4(1): 3-12.
5. Babcock TA, Novak T, Ong E, Jho DH, Helton WS, Espat NJ. Modulation of lipopolysaccharide-stimulated macrophage tumor necrosis factor-alpha production by omega-3 fatty acid is associated with differential cyclooxygenase-2 protein expression and is independent of interleukin-10. J Surg Res. 2002; 107(1): 135-139. doi: http://dx.doi.org/10.1006/jsre.2002.6498
6. Ong E, Espat NJ. Gastric Adenocarcinoma. Pocket General Surgery. 2013; 1.
7. Ong E, Helton WS, Espat NJ. Operative Experience of U.S. General Surgery Residents: Liver and Pancreas 1989-2001. Journal of Gastrointestinal Surgery. 2003; 7(2): 311.
8. Ong ES, Gao XP, Xu N, et al. E. coli pneumonia induces CD18-independent airway neutrophil migration in the absence of increased lung vascular permeability. Am J Physiol Lung Cell Mol Physiol. 2003; 285(4): L879-L888. doi: 10.1152/ajplung.00134.2003
9. Ong E, Espat NJ, Helton WS. Current Treatment Options in Infectious Diseases. Hepatic Abscess. 2003; 5(5): 393-406.
10. Espat NJ, Ong ES, Helton WS, Nyhus LM. 1990-2001 US general surgery chief resident gastric surgery operative experience: analysis of paradigm shift. J Gastrointest Surg. 2004; 8(4): 471-478. doi: 10.1016/j.gassur.2004.02.002
11. Jho DH, Engelhard HH, Gandhi R, et al. Ciliaryneurotrophic factor upregulates ubiquitin-proteasome components in a rat model of neuronal injury. Cytokine. 2004; 27(6): 142-151. doi: 10.1016/j.cyto.2004.05.003
12. Ong E, Espat NJ, Helton WS. Hepatic Abscess. Surgical Decision Making- Fifth Edition. 2005.
13. Ong E. My Bushidos Code to a Healthy Surgical Lifestyle. Current Surgery. 2005; 62(2): 239.
14. Ong E, Gao XP, Predescu D, Broman M, Malik AB. Role of phosphatidylinositol 3-kinase-gamma in mediating lung neutrophil sequestration and vascular injury induced by E. coli sepsis. Am J PhysiolLung Cell Mol Physiol. 2005; 289(6): L1094-L2103. doi: 10.1152/ajplung.00179.2005
15. Ong ES, Poirier M, Espat NJ. Hepatic intra-arterial chemotherapy. Ann SurgOncol. 2006; 13(2): 142-149. doi: 10.1245/ASO.2006.01.005
16. Ong ES, Helton WS, Jho D, Espat NJ. SURGISIS-assisted surgical site control in the delayed repair of a complex bile duct injury after laparoscopic cholecystectomy. J Gastrointest Surg. 2006; 10(2): 202-206.
17. Sharif S, Broman M, Babcock T, et al. A priori dietary omega-3 lipid supplementation results in local pancreatic macrophage and pulmonary inflammatory response attenuation in a model of experimental acute edematous pancreatitis (AEP). JPEN J Parenter Enteral Nutr. 2006; 30(4): 271-276. doi: 10.1177/0148607106030004271
18. Ong E, Espat NJ. Bile Secretion. Surgery of the Liver, Biliary Tract and Pancreas- Fourth Edition. Blumgart LH. 2007. doi: 10.1097/01.shk.0000278501.33580.57
19. Jho DH, Jho DJ, Chejfec G, Ahn M, Ong ES, Espat NJ. Primary biliary B-cell lymphoma of the cystic duct causing obstructive jaundice. Am Surg. 2007; 73(5): 508-510.
20. Ong ES, Alassas M, Dunn KB, Rajput A. Colorectal cancer surgery in the elderly: acceptable morbidity? Am J Surg. 2008; 195(3): 344-348. doi: 10.1016/j.amjsurg.2007.12.022
21. Ong ES, Alassas MA, Bogner PN, Bullard Dunn K, Chey WY, Gibbs JF. Total gastrectomy for gastric dysplasia in a patient with attenuated familial adenomatous polyposis syndrome. J ClinOncol. 2008; 26(21): 3641-3642. doi: 10.1200/JCO.2008.16.7056
22. Brovkovych V, Gao XP, Ong E, et al. Augmented inducible nitric oxide synthase expression and increased NO production reduce sepsis-induced lung injury and mortality in myeloperoxidase-null mice. Am J Physiol Lung Cell Mol Physiol. 2008; 295(1): L96-L103. doi: 10.1152/ajplung.00450.2007
23. Jarzembowski TM, Sankary HN, Bogetti D, et al. Living Donor Liver Graft Salvage after Rupture of Hepatic Artery Pseudoaneursym. International Surgery. 2008; 93(5): 300-303.
24. Hansen AJ, Augenstein J, Ong ES. Large Subcapsular Liver Hematoma Following Single-Incision Laparoscopic Cholecystectomy. JSLS. 2011; 15(1): 114-116.doi: 10.4293/108680811X13022985131615
25. Chi A, Jang S, Welsh J, et al. Feasibility of Helical Tomothraphy in Sterotactic Body Radiation Therapy for Centrally Located Early Stage Non-small Cell Lung Cancer or Lung Metastases. Int J Radiat Oncol Biol Phys. 2011. doi: 10.1016/j.ijrobp.2010.11.051
26. Uribe AG, Chang CC, Yapici MK, et al. High-Transmission -Efficiency and Side-Viewing Micro OIDRS Probe for Fast and Minimally Invasive Tumor Margin Detection. IEEE Sensor Journal. 2011; 11(4): 891-896.
27. Zimmerman H, Latifi R, Dehdashti B, et al. Intensive laparoscopic training course for surgical residents: program description, initial results, and requirements. Surgical Endoscopy. 2011; 25(11): 3636-3641. doi: 10.1007/s00464-011-1770-6
28. Cueto CV, Szeja S, Wertheim BC, Ong ES, Tsikitis VL. Disparities in Treatment and Survival of White and Native American Patients with Colorectal Cancer: A SEER Analysis. J Am CollSurg. 2011; 29. doi: 10.1016/j.jamcollsurg.2011.05.026
29. Rose J, Jie T, Usera P, Ong ES. Pancreaticoduodencetomy for Primary Pancreatic Lymphoma. Gastrointest Cancer Res. 2012; 5(1): 32-34.
30. Konstantantinidis IT, Young C, Tsikitis VL, Lee EM, Jie T, Ong E. Cytoreductive Surgery and HyperthermicIntraperitonealChemoperfusion: The University of Arizona Early Experience. World J Gastrointest Surg. 2012; 4(6): 135-140.
31. Amini A, Patanwala AE, Maegawa F, et al. Effect of Epidural Analgesia on Postoperative Complications Following Pancreaticoduodenectomy. J Am CollSurg. 2012; 204(6): 1000-1004. doi: 10.1016/j.amjsurg.2012.05.022
32. Ong E, Diven C, Abrams A, Lee E, Mahadevan D. Laparoscopic Hyperthermic Intraperitoneal Chemotherapy (HIPEC) for Malignant Ascites from GIST. J Palliat Care. 2012; 28(4): 293-296.
33. Lee E, Jones C, Ong E. Single-Incision Sleeve Gastrectomy for successful treatment of a gastrointestinal stromal tumor. JSLS. 2013; 17(3): 471-475. doi: 10.4293/108680813X13693422522033
34. Chi A, Nguyen NP, Xu J, et al. Correlation of small bowel dose and acute lower GI toxicity in postoperative pelvic intensity-modulated radiotherapy for endometrial cancer: 3 different approaches of small bowel delineation. Technol Cancer Res Treat. 2012; 11(4): 353-359.
35. Adamas RW, Benjamin MA, Teeple MK, et al. A comparison of Unguided versus Guided Case-Based Instruction on the Surgery Clerkship. Journal of Surgical Education. 2013; 70(6): 821-825. doi: 10.1016/j.jsurg.2012.06.014
36. Kaplan SJ, Carroll JT, Chuu A, Nematollahi S, Adamas RW, Ong E. Utilization of a Non-Preserved Cadaver to address deficiencies in Technical Skills during the third year of medical school. World J Surg. 2013; 37(5): 953-955. doi: 10.1007/s00268-013-1905-0
37. Glazer ES, Amini A, Jie T, Gruessner RW, Krouse RS, Ong ES. Recognition of Complications After Pancreaticoduodenectomy for Cancer Determines inpatient mortality. JOP. 2013; 14(6): 626-631. doi: 10.6092/1590-8577/1883
38. Kaplan SJ, Carroll JT, Nematollahi S, Chuu A, Adamas RW, Ong E. Utilization of a non-preserved cadaver to address deficiencies in technical skills during the third year of medical school: a cadaver model for teaching technical skills. World J Surg. 2013; 37(5): 953-955.
39. Liesl N, Navaneeth C, Kumar C, Glazer Evan S, Ong Evan S. A Dieulafoy lesion as the cause of massive upper gastrointestinal bleeding after a distal pancreatectomy and splenectomy: Case report and literature review. J Surgery. 2013; 1(2): 3.
Scarborough General Hospital
Toronto, Ontario, Canada
Dr. Ryan Neinstein is a Board Certified Plastic Surgeon and Fellow of the Royal College of Physicians and Surgeons of Canada. After obtaining his bachelor of science with honors in genetics at The University of Western Ontario, he went on to obtain his Doctor of Medicine at the same institution. Dr. Neinstein spent time volunteering as a medic in Israel while an undergraduate student. His affinity towards science along with his interest in helping others drove him into medicine. While in medical school Dr. Neinstein became enamored with surgery and how technical mastery can deliver such dramatic and fulfilling results to the patient.
While in his 5 year Plastic Surgery Residency at The University of Toronto, Dr. Neinstein became actively involved in academic research. Dr. Neinstein published papers in areas including hand surgery, aesthetic surgery, breast reconstruction and pediatric facial fractures. His dedicated time to improving the field was rewarded with the Best Paper Award at the 2011 American Society of Reconstructive Microsurgery Meeting. The goal of that research project was to improve outcomes for women undergoing breast reconstruction after breast cancer.
After his 5-year surgical residency, Dr. Neinstein was selected to become one of two fellows at the most prestigious aesthetic surgery fellowship in the world. During his time at the epicenter of aesthetic surgery, the Manhattan Eye, Ear and Throat Hospital (MEETH) under the tutelage of Dr. Sherrell Aston, Dr. Neinstein was trained in the most advanced Aesthetic Surgical techniques of the Face, Nose, Breast and Body. His other mentors included internationally renowned Plastic Surgeons such as Dr. Alan Matarasso, Dr. Daniel Baker, Dr. Nicolas Tabbal, and Dr. Gerald Pitman.
Dr. Neinstein is bringing his sophisticated Manhattan approach to Aesthetic Surgery back to his hometown of Toronto.
His research interest focuses on aesthetic surgery.
LEADERSHIP AND COMMITTEE WORK
University of Toronto Surgery Evaluation Task Force Jan. 2008- June 2012
Resident representative on undergraduate and post-graduate surgical education task force committee
President, Schulich School of Medicine Surgery Club Sept. 2004 – June 2005
Organized interactive sessions with surgical program directors and residents along with introductory suturing sessions, conference organizer “Lifestyles in Surgery 2005”
Executive Commissioner for Holocaust Awareness, Jewish Student Union Sept. 2001 - May 2002
Ran a 24 hour outdoor vigil, organized conference with Holocaust Survivors and History Professors
Interviewer, Schulich School of Medicine Admissions Committee March 2006
Senior Medical student representative on Medical Admissions Committee
Interviewer, Schulich School of Medicine Admissions Committee March 2006
Senior Medical student representative on Medical Admissions Committee
Workshop Leader, Medical School Discovery Day May 2005
Led High School students through the discovery day program conducted by The Canadian Medical Hall of Fame
Tutor, Medical Student After School Program Sept. 2003 - June 2005
Offered free tutoring for London High School Students weekly at the Jewish Community Centre
Volunteer First Responder, Israeli Ambulance Service, Tel Aviv, Israel Summer 2001
Trained by Israeli Army Paramedics as a first responder along with multi casualty trauma training, full time ambulance volunteer
1. Neinstein RM, Matarasso DA, Abramson D. Umbilical hernia repair in conjunction with abdominoplasty using the Ventralex hernia patch. Plastic & Reconstructive Surgery Journal.
2. Neinstein RM, Bell T. How does non-surgical facial rejuvenation play a role in plastic surgeons practices? Aesthetic Surgery Journal.
3. Neinstein RM, Matarasso A. Liposuction chapter in Operative techniques in Plastic, Aesthetic, and Reconstructive Surgery. Plastic & Reconstructive Surgery. 2012.
4. Neinstein RM, Forrest CR. Morphology of the inferior rectus muscle in pediatric orbital floor fractures: Clinical correlations and outcome predictors . Journal of Plastic, Reconstructive, and Aesthetic Surgery. 2012; 27.
5. Neinstein RM, Zhong T, Hoffer S, Lipa J, Neligan P. Intravenous Fluid Infusion Rate in Microsurgical Breast Reconstruction: Important Lessons Learned From 354 Free Flaps. Plastic & Reconstructive Surgery. 2011; 128(6): 1153-1160. doi: 10.1097/PRS.0b013e318221da56
6. Neinstein RM, Ray JG, Mahoney JM, Musgrave MA, Connelly PW. Effect of breast reduction surgery on indicators of insulin resistance: a pilot study (Ongoing study funded by Canadian Society of Plastic Surgery Educational Foundation grant).
7. Dvali LT, Anastakis DJ, Neinstein RM. Trends with complete digital amputations undergoing replantation surgery: a ten-year retrospective study . HAND. 2012; 7(3): 263-266.
8. Dvali LT, Anastakis DJ, Neinstein RM. Review of Theological and Doctrinal Considerations of Three Religions Impacting Digital Replantation Decision Making. HAND. 2012; 7(3): 346-347. doi: 10.1007/s11552-012-9426-0
9. Neinstein RM, Borschel GH, Zuker RM. Staged management of a congenital nevus of the breast and abdomen presenting in a female infant. Can J Plastic Surg. 2006; 14: 91-93. doi:
10. Neinstein RM, Death AB, Gan BS. A clinical audit of the combined plastic surgery/physical medicine and rehabilitation amputee clinic at UWO. Can J. Plastic Surg. 2008; 16: 23-26.
Department of Surgery
University of Cincinnati
2600 Clifton Ave, Cincinnati
OH 45220, USA
Dr. George F. Babcock received his PhD from the University of Nebraska, College of Medicine, Omaha Nebraska, USA. He is currently Professor of Surgery and Adjunct Professor of Cancer and Cell Biology at the University of Cincinnati, College of Medicine. He is also the Deputy Director for Research at Shriners Hospitals for Children-Cincinnati, OH, USA. He is Chair of the universities Institutional Animal Care and Use Committee. He has been on the Editorial Board of Burns, Journal of Experimental and Clinical Cancer Research, The Journal of Nutritional Immunology and Biochemical Pharmacology. Additional he has reviewed manuscripts for 26 other journals. He is an active researcher with over 160 peer reviewed papers, 17 book chapters, and the series editor for 4 books and the edition editor for 1. Dr. Babcock is a member of 17 professional societies. He has served on NIH and DOD study sections and is currently the chair of the Military Infectious Diseases Research Program (MIDRP) study section.
His general research interests include Immunology, Microbiology and Inflammation. More specifically the lab is interested in the effects of burns and other trauma on the immune response with an emphasis on the innate immune system. Related to this is an interest in the regulation of apoptosis and adhesion molecules in neutrophils especially after burn trauma. The onset of infections and alterations in wound healing following thermal injury are also being investigated. In addition, area of research include the development of treatments for infected burn wounds especially the use of new anti-microbial agents and the use of biological response modifiers, research into modulation of the immune system bymicrovesicles and by nutritional manipulation of the host following burn injury, an examination of the immunotoxicolgy of agents encountered in the environment and the development and use of flow and image cytometry to measure biological responses.
MEMBERSHIP IN PROFESSIONAL SOCIETIES AND HONORARY SOCIETIES:
• American Association for Advancement of Science
• American Association for Cancer Research
• American Association for Laboratory Animal Science
• American Association of Immunologists
• American Burn Association
• American Society for Microbiology
• Alpha Epsilon Delta
• International Clinical Cytometry Society
• International Society for Advancement of Cytometry
• International Society for Infections in the Immunocompromised Host
• New York Academy of Sciences
• Public Responsibility in Medicine and Research (PRIM&R)
• Scientists Center for Animal Welfare (SCAW)
• Sigma XI
• Society for Leukocyte Biology
• Transplantation Society
2010-present Member, Research Cyotmetry Core Facility, Cincinnati Childrens Hospital Medical Center
2010-present Member, AHC Compliance Committee
2010-present Member Public Responsibility in Medicine and Research (PRIM&R) Conference Planning Committee
2008-present Member ROSE program committee
2008-present Member Ethics committee, Shriners Hospital for Children, Cincinnati Burns Hospital
2004-present Member Institutional Biosafety Committee, Univ. Cincinnati
1997-present Member, Institutional Animal Care and Use Committee (ICUC), University of Cincinnati
1984 -present Member Animal Research Committee - Shriners Burns Institute
3-21-12 Public Responsibility in Medicine and Research (PRIM&R) Conference. Invited to present a didactic session entitled “Will your enigma become a stigma? The probities and pitfalls of institutional self-reporting “and present a work shop entitled “Review of protocols: balancing ethics, compliance, and science “
9-19-12 2nd Annual Imaging and Cytometrty Research Day, Ohio River Valley Cytomtery Assocation (ORVCA). Invited to present a round table discussion on “Sample Preparation for Cell Sorting” with Philip Hexley, Ph.D., Cincinnati, OH, USA.
5-19-13 XXVII International Congress of the International Society for the Advancement of Cytometry. Invited to chair workshop entitled “Functional Analy Mitochondria and Transporters “Content and High Throughput Appliations” with Padma Narayanan, Ph.D., San Diego, CA, USA.
9-18-13 3rd 2nd Annual Imaging and Cytometrty Research Day, Ohio River Valley Cytomtery Assocation (ORVCA). Invited to present a round table discussion on “Microparticles and Microvesicles”with Philip Hexley, Ph.D., Cincinnati, OH, USA.
1. Babcock GF, Berryhill DL, Marsh DH. R-Factors of Escherichia coli from beef and humans. Appl. Microbiol. 1973; 25: 21-23.
2. Mc Carthy RE, Arnold LW, Babcock GF. Dextran sulfate: an adjuvant for cell-mediated immune response. Immunology. 1977; 32: 963-974.
3. Babcock GF, Mc Carthy RE. Suppression of cell-mediated immune responses by dextran sulfate. Immunology. 1977; 33: 925-930.
4. Mc Carthy RE, Babcock GF. Simultaneous stimulation and suppression of two different indicators of the cell-mediated immune response by the immunoregulator dextran sulfate. Immunology. 1978; 34: 927-930.
5. Whitmore AC, Babcock GF, Haughton G. Genetic control of susceptibility of mice to Rous sarcoma virus tumorigenesis. II. Segregation analysis of strain A.SW-associated resistance to primary tumor induction. J. Immunol. 1978; 121: 213-220.
6. Haughton G, Lanier LL, Babcock GF. The murine kappa light chain shift. Nature. 1978; 275: 154-157. doi: 10.1038/275154a0
7. Babcock GF, Lanier LL, Lynes MA, Haughton G. A simple method for the preparation of antisera specific for murine immunoglobulin heavy chains. J Immunol Methods. 1978; 23: 1-6. doi: 10.1016/0022-1759(78)90103-5
8. Lynes MA, Lanier LL, Babcock GF, Haughton G. Antigen-induced murine B cell lymphomas. Induction and characterization of CH1 and CH2. J. Immunol. 1978; 121: 2352-2357.
9. Lanier LL, Babcock GF, Lynes MA, Haughton G. Early detection of the CH1 murine and lymphoma by tumor-associated idiotype in the serum. Int. J. Cancer. 1979; 24: 53-59. doi: 10.1002/ijc.2910240110
10. Lanier LL, Babcock GF, Lynes MA, Haughton G. Antigen-induced murine B cell lymphomas. II. Passive anti-idiotype serum therapy and its combined effect with chemotherapy. J Natl Cancer Inst. 1979; 63: 1417-1422. doi: 10.1093/jnci/63.6.1417
11. Banks RA, Babcock GF, Whitmore AC, Haughton G. Effect of immunological intervention on in vivo murine Rous sarcoma virus tumorigenesis. J Natl Cancer Inst. 1979; 63: 1423-1431. doi: 10.1093/jnci/63.6.1423
12. Lanier, L, Babcock GF, Raybourne R, Arnold L, Warner N, Haughton G. Mechanism of a B cell lymphoma immunotherapy with passive xenogenic anti-idiotype serum. J Immunol. 1980; 125: 1730-1736.
13. Amoscato A, Babcock GF, Nishioka K. A cautionary note regarding contaminants in commercial preparations of the tetrapeptide tuftsin: Analysis by high performance liquid chromatography. J. Chromatogr. 1981; 205: 179-184.
14. Nishioka K, Amoscato A, Babcock GF. Tuftsin: A hormone-like tetrapeptide with antimicrobial and antitumor activities. Life Sci. 1981; 28: 1081-1090. doi: 10.1016/0024-3205(81)90684-6
15. Philips JH, Babcock GF, Nishioka K. Tuftsin: A naturally occurring immunopotentiating factor. In vitro enhancement of murine natural cell-mediated cytotoxicity. J Immunol. 1981; 126: 915-921.
16. Noyes RD, Babcock GF, Nishioka K. Antitumor activity of tuftsin on murine melanoma in vivo. Cancer Treat Rep. 1981; 65: 673-675.
17. Nishioka K, Babcock GF, Philips JH, Noyes RD. Antitumor effect of tuftsin. Mol. Cell Biochem. 1981; 41: 13-18. doi: 10.1007/BF00225293
18. Babcock GF, Noyes R, Nishioka K. The effect of tuftsin and immunopotentiating peptide, on Couldman S-91 melanoma in vivo. Pigment Cell Res. 1981; 11: 623-628.
19. Nishioka K, Takami H, Noyes RD, Babcock GF. Cloudman S-91 melanoma colony assay in the lungs of mice and the profiles of the biochemical tumor markers, tyrosinase and polyamines. Pigment Cell Res. 1981; 11: 617-621.
20. Philips JH, Babcock GF. NKP-15: A monoclonal antibody reactive against purified human natural killer cells and granulocytes. Immunol. Lett. 1983; 6: 143-149.
21. Babcock GF, Philips JH. NK cells: Light and electron microscope characteristics. Survey Immunol. Res. 1983; 2: 88-101.
22. Lanier LL, Engleman EG, Gatenby P, Babcock GF, Warner NL, Herzenberg LA. Correlation of functional properties of human lymphoid cell subsets and surface marker phenotypes using multiparameter analysis and flow cytometry. Immunol. Rev. 1983; 74: 143-160. doi: 10.1111/j.1600-065X.1983.tb01088.x
23. Amoscato AA, Davies PJA, Babcock GF, Nishioka K. Receptor-mediated internalization of tuftsin by human polymorphonuclear leukocytes. J Reticuloendothel Soc. 1983; 34: 53-67.
24. Lanier LL, Le AM, Philips JH, Warner NL, Babcock GF. Subpopulations of human natural killer cells defined by expression the Leu 7 (HNK-1) and Leu 11 (NKP-15) antigens. J Immunol. 1983; 131: 1789-1796.
25. Babcock GF, Amoscato A, Nishioka K. The effect of tuftsin on the migration, chemotaxis and differentiation of macrophages and granulocytes. Ann. N.Y. Acad. Sci. 1983; 419: 64-74. doi: 10.1111/j.1749-6632.1983.tb37092.x
26. Amoscato AA, Davies PN, Babcock GF, Nishioka K. Receptor-mediated internalization of tuftsin. Ann NY Acad Sci. 1983; 419: 114-134. doi: 10.1111/j.1749-6632.1983.tb37097.x
27. Philips JH, Nishioka K, Babcock GF. Tuftsin-induced enhancement of human and murine natural cell-mediated cytotoxicity. Ann NY Acad Sci. 1983; 419: 192-204. doi: 10.1111/j.1749-6632.1983.tb37104.x
28. Nishioka K, Babcock GF, Philips JH, Banks RA, Amoscato AA. In vivo and in vitro antitumor activities of tuftsin. Ann N Y Acad Sci. 1983; 419: 234-241. doi: 10.1111/j.1749-6632.1983.tb37109.x
29. Lanier LL, Philips JH, Warner NL, Babcock GF. A human natural killer cell associated antigen defined by monoclonal antibody Leu 11 (NKP-15): Functional and two color cytometry analysis. J Leukocyte Biol. 1984; 35: 11-17.
30. Nishioka K, Amoscato AA, Babcock GF, Banks RA, Philips JH. Tuftsin: An immunomodulating peptide hormone and its clinical potential as a natural biological response modifier. Cancer Invest. 1984; 2: 39-49.
31. Amoscato AA, Babcock GF, Nishioka K. Synthesis and biological activity of L-3-4-dehydroproline 3 tuftsin. Peptides. 1984; 5: 489-494.
32. Pollack RE, Babcock GF, Romsdahi MM, Nishioka K. Surgical stress-mediated suppression of natural killer cell cytotoxicity. Cancer Res. 1984; 44: 3888-3891.
33. Lewis DE, Puck JM, Babcock GF, Rich RR. Lymphocyte subsets in patients with acquired immunodeficiency syndrome (AIDS), AIDS related complex (ARC) and acute viral infections. Trans Assoc Am Phys. 1984; 97: 197-204.
34. Ota DM, Jessup JM, Babcock GF, et al. Immune function during intravenous administration of a soybean oil emulsion. J Parent Enter Nutr. 1985; 9: 23-27. doi: 10.1177/014860718500900123
35. Lewis DE, Puck J, Babcock GF, Rich RR. Disproportionate expansion of a minor T cell subset in patients with lymphadenopathy syndrome and acquired immunodeficiency syndrome. J Infect Dis. 1985; 151: 555-559. doi: 10.1093/infdis/151.3.555
36. Banks RA, Nishioka K, Kazazi F, Babcock GF. Effect of tuftsin on in vivo development of 3 methylcholanthrene-induced primary fibrosarcoma and Lewis lung carcinoma in mice. J. Natl. Cancer Inst. 1985; 74: 1079-1083.
37. Schantz DSP, Romsdahi MM, Babcock GF, Nishioka K, Goepfert H. The effect of surgery on natural killer cell activity in head and neck cancer patients: in vitro reversal of postoperatively suppressed immunosurveillance system. Laryngoscope. 1985; 95: 588-594.
38. Jessup JM, Babcock GF. Lymphoproliferative response to autologous tumor-associated antigens correlates with good prognosis in patients with colorectal carcinoma. Surg. Forum. 1985; 36: 384-385.
39. Lai CS, Babcock GF, Alexander JW. Indefinite survival of rat skin allograft induced by topical cyclosporine A. Surg. Forum. 1986; 37: 603-604.
40. Weiner D, Watson S, Babcock GF, Keller S. Expression of human T antigens in interspecies hybridomas. Cell Immunol. 1986; 100: 197-209. doi: 10.1016/0008-8749(86)90019-5
41. Amoscato AA, Babcock GF, Sramkoski RM, Hynd BA, Alexander JW. Synthesis of two biologically active fluorescent probes of thymopentin. Int. J. Peptide Protein Res. 1987; 29: 177-186. doi: 10.1111/j.1399-3011.1987.tb02244.x
42. Lai CS, Alexander JW, Babcock GF. Combined use of topical cyclosporine A and silver sulfadiazine on allografts infected with Pseudomonas in burned rats. Burns. 1987;13: 181-184.
43. Bowlin TL, McKown BJ, Babcock GF, Sunkara PS. Intracellular polyamine biosynthesis is required for interleukin 2 responsiveness during lymphocyte mitogenesis. Cell Immunol. 1987; 106: 420-427.
44. Lai CS, Wesseler TA, Alexander JW, Babcock GF. Long term survival of skin allografts in rats treated with cyclosporine A. Transplantation. 1987 44: 83-87.
45. Babcock GF, Taylor AF, Hynd BA, Sramkoski RM, Alexander JW. Flow cytometric analysis of lymphocyte subset phenotypes comparing normal children and adults. Diagn. Clin. Immunol. 1987; 5: 175-179.
46. Banks RA, Babcock GF, Nishioka K. Effect of oral administered or lipisome-encapsulated tuftsin on survival of C57BL/6 mice inoculated with Lewis lung carcinoma. J. Exp. Clin. Cancer Res. 1988; 7: 21-26.
47. Zhao XF, Schroeder TJ, Alexander JW, Miskell P, Gonce SJ, Babcock GF. The prolongation of skin allograft survival by topical use of cyclosporine A. Transplant. Proc. 1988; 20: 670-673.
48. Perez RV, Heyd TJ, Munda R, Babcock GF, Alexander JW. Induction of long term cardiac allograft survival with multiple donor specific transfusions and cyclosporine. Curr. Surg. 1988; 49: 9-12.
49. Babcock GF. Workshop on flow cytometry methodologies. Cytometry. 1988; 3: 106-107. doi: 10.1002/cyto.990090822
50. Babcock GF, Smith LA, Alexander JW. A comparison of single and multiple blood transfusions on the mixed lymphocyte response of rats. Transplant. Proc. 1988; 20: 194-198.
51. Zhao XF, Schroeder T, Alexander JW, Babcock GF. The synergistic effect of low dose cyclosporine A and fluocinolone acetonide on the survival of rat skin allogenic skin grafts. Transplantation. 1988; 46: 490 492.
52. Amoscato AA, Balasubramaniam A, Alexander JW, Babcock GF. Degradation of thymopentin by human lymphocytes: evidence for aminopeptidase activity. Biochim. Biophys. Acta. 1988; 955: 164-174.
53. Perez RV, Babcock GF, Alexander JW. Altered macrophage function in dietary immunoregulation. J Parent Enter Nutr. 1989; 13(1): 1-4. doi: 10.1177/014860718901300101
54. Amoscato AA, Alexander JW, Babcock GF. Surface aminopeptidase activity of human lymphocytes. I. Biochemical and biological properties. J. Immunol. 1989; 142: 1245-1252.
55. Perez RV, Babcock GF, Alexander JW. Immunoregulation of transfusion induced immunosuppression with inhibitors of arachidonic acid metabolism. Transplantation. 1989; 48: 85-87.
56. Babcock GF, Alexander JW, Warden GD. Flow cytometric analysis of neutrophil subsets in thermally injured patients developing infection. J Clin Immunol Immunopathol. 1990; 54: 117-125.
57. Peck MD, Ogle CK, Alexander JW, Babcock GF. Effect of dietary fatty acids in response to Pseudomonas infection in burned mice. J Trauma. 1990; 30: 448-452.
58. Sasamoto Y, Alexander JW, Babcock GF. Prolonged survival of reconstituted skin grafts without immunosuppression. J Burn Care Rehabil. 1990; 11: 190-200.
59. Fang C, Peck MD, Alexander JW, Babcock GF, Warden GD. The effect of free radical scavengers on outcome after infection in burned mice. J Trauma. 1990; 30: 453-456.
60. Alexander JW, Boyce ST, Babcock GF, Childress CP, Ash SK. The process of microbial translocation. Ann. Surg. 1990; 212: 496-512.
61. Amoscato AA, Sramkoskii RM, Babcock GF, Alexander JW. Surface aminopeptidase activity of human tumor cell lines. Biochem Biophys Acta. 1990; 104: 317-319.
62. Sramkoskii RM, Babcock GF. The use of microbead alignment standards to standardize a flow cytometer. Flow Cytometry Standards. 1990; 2: 1-9.
63. Peck MD, Ogle CK, Alexander JW and Babcock GF. Dietary fat and infection in burned animals. J. Burn Care Rehabil. 1991; 12: 43-45.
64. Alexander JW, Gianotti L, Pyles T, Carey MA, Babcock GF. Distribution and survival of Escherichia coli translocating from the intestine following thermal injury. Ann Surg. 1991; 213: 558-567.
65. White-Owen CL, Alexander JW, Babcock GF. Reduced expression of neutrophil CD11 and CD16 after severe traumatic injury. J. Surg. Res. 1991; 52: 22-26. doi: http://dx.doi.org/10.1016/0022-4804(92)90273-3
66. Alexander JW, Babcock GF, First MR, et al. The induction of immunologic hyporesponsiveness by preoperative donor specific transfusion and cyclosporine in human cadaveric transplants. Transplantation. 1992; 53: 423-427.
67. De Stefano JA, Sleight RG, Babcock GF, Sramkoski RM, Walzer PD. Isolation of Pneumocystis carinii cysts by flow cytometry. Parasitol. Res. 1992; 78: 179-182. doi: 10.1007/BF00931724
68. Gianotti, L, Pyles T, Alexander JW, Babcock GF, Carey MA. Impact of blood transfusion and burn injury on microbial translocation and bacterial survival. Transfusion. 1992; 32: 312-317. doi: 10.1046/j.1537-2995.1992.32492263443.x
69. Peck MD, Babcock GF, Alexander JW. The role of protein and calorie restriction in outcome from Salmonella infection in mice. J. Parenter. Enter. Nutr. 1992; 16: 561-565. doi: 10.1177/0148607192016006561
70. White-Owen, C, Alexander JW, Babcock GF. Reduced PMN *2 integrins after trauma: a possible role for colony stimulating factors. Clin. Exp. Immunol. 1993; 92: 477-481.
71. White-Owen C, Alexander JW, Sramkoski RM, Babcock GF. A rapid whole blood microassay for neutrophil phagocytosis using flow cytometry. J. Clin. Microbiol. 1992; 30: 2071-2076.
72. Peck MD, Babcock GF, Alexander JW. The role of protein and calorie restriction in outcome from Salmonella infection in mice. J. Parent. Enter. Nutr. 1992; 16: 561-565. doi: 10.1177/0148607192016006561
73. Gianotti L, Munda R, Alexander JW, Tchervenkov JI, Babcock GF. Microbial translocation: a potential mechanism for infection during acute pancreatitis. Pancreas. 1993; 8: 551-558.
74. Gianotti L, Alexander JW, Pyles T, Babcock GF. Relationship between extent of burn injury and magnitude of microbial translocation from the intestine. J. Burn Care Rehabil. 1993; 14: 336-342.
75. Alexander JW, First MR, Davies CB, Campbell P, Babcock GF. Donor-specific transfusion-induced tolerance in animals and man: a therapeutic strategy. Transplant Sci. 1993; 3: 72-75.
76. Gianotti L, Pyles T, Alexander JW, Fukushima R, Babcock GF. Identification of the blood component responsible for increased susceptibility to gut-derived infection. Transfusion. 1993; 33: 458-465. doi: 10.1046/j.1537-2995.1993.33693296806.x
77. Madden RL, Davies CB, Alexander JW, Babcock GF, Denman DL. The effect of posttransplant TLI combined with cyclosporine and a donor-specific transfusion on rat cardiac allograft survival. Transplant. Sci. 1993; 3: 38-40.
78. Gianotti L, Pyles T, Alexander JW, Babcock GF. Prostaglandin E1, analogues, misoprosil and enisoprost decrease microbial translocation in thermally injured mice. Circulatory Shock. 1993; 40: 243-249.
79. Wolos JA, Frondorf KA, Babcock GF, Stripp SA, Bowlin TA. Immunomodulation by an inhibitor of S-adenosyl-L-homocysteine hydrolase: inhibition of in vitro and in vivo allogeneic responses. Cell. Immunol. 1993; 149: 402-408. doi: 10.1006/cimm.1993.1165
80. Babcock GF, Sramkoski RM, Alexander JW. The advantages and disadvantages of the routine use of three color immunofluorescence and flow cytometry in the research and clinical laboratories to study leukocytes. Crit. Rev. Biotechnol. Bioeng. 1994; 1: 235-267.
81. Solomkin JS, Bass RC, Bjornson HS, Tindal CJ, Babcock GF. Alterations of neutrophil responses to tumor necrosis factor alpha and interleukin-8 following human endotoxemia. Infect. Immun. 1994; 62: 943-947.
82. Gennari R, Alexander JW, Pyles TE, Babcock GF. Heparan sulphate increases survival during gut derived sepsis by decreasing bacterial translocation and enhancing host defense. Shock. 1994; 2: 246-250.
83. Swope VB, Abdel-Malek Z, et al. Differential synthesis of IL-1* and IL-1* by neonatal and adult melanocytes. J. Invest. Dermatol. 1994; 102: 749-753.
84. De Stefano JA, Sleight RG, Babcock GF, Walzer PD. Fractionation of Pneumocystis carinii, developmental stages by counter flow centrifugal elutriation and sequential filtrations. Prasitol. Res. 1994; 80: 1-9. doi: 10.1007/BF00932616
85. Abdel-Melek ZV. Swope D, Smalara G, et al. Analysis of the UV induced melanogenesis and growth arrest of human melanocytes. Pig. Cell Res. 1994; 7: 326-332. doi: 10.1111/j.1600-0749.1994.tb00635.x
86. Gianotti L, Alexander JW, Gennarim R, Pyles T, Babcock GF. Oral glutamine decreases bacterial translocation and improves survival in experimental gut-origin sepsis. J. Parent. Enter. Nutr. 1995; 14: 69-74. doi: 10.1177/014860719501900169
87. Barker DK, Dixon EE, Medrano D, et al. Comparison of the responses of human melanocytes with different melanin contents to UVB irradiation. Cancer Res. 1995; 55: 4041-4046.
88. Gianotti, L, Alexander JW, Pyles T, Gennari R, Babcock GF. Translocation and survival of Bacteroides fragilis following thermal injury. J. Burn Care Rehab. 1995; 16: 127-131.
89. Nordlund JJ, Casato M, Babcock G, Takei F. Low ICAM-1 expression in the epidermis of depigmenting C57BL/6J-mivit/mivit mice: a possible cause of muted contact sensitization. Exp. Dermatol. 1995; 4: 20-29. doi: 10.1111/j.1600-0625.1995.tb00217.x
90. Peck MD, Babcock GF, Alexander JW, Billiar T, Ochoa J. High doses of dietary arginine during repletion impair weight gain and increase infectious mortality in protein-malnourished mice. Brit.J. Nutrition. 1995; 74: 787-795. doi: http://dx.doi.org/10.1079/BJN19950006
91. Babcock GF, Alexander JW. The effects of blood transfusion on cytokine production by TH1 and TH2 lymphocytes in the mouse. Transplantation. 1996; 61: 465-468.
92. Osterburg AR, Yamaguchi R, Robinson CT, Hyon SH, Babcock GF. The Effects of (-)-Epigallocatechin 3-Galate on Wound Closure and Infections in Mice. Surg Res Open J. 2014; 1(1): 1-9. 10.17140/SROJ-1-101
93.Osterburg AR, Yamaguchi R, Robinson CT, Hyon SH, Babcock GF. The Effects of (-)-Epigallocatechin- 3-Galate on Wound Closure and Infections in Mice. Surg Res Open J. 2014; 1(1): 1-9.doi: 10.17140/SROJ-1-101
Consultant Upper GI & General Surgeon
Mid Essex Hospital Services NHS Trust
Essex CM1 7ET, UK
Consultant Upper GI & General Surgeon with an interest in Minimally Invasive Oesophagogastric Cancer Surgery.
Broomfield Hospital, Mid Essex Hospital Services NHS Trust
Permanent full time post from December 2013
As an Upper GI & General Surgery Consultant with a major interest in oesophagogastric cancer resection surgery, I perform all the operations in the spectrum of upper gastrointestinal surgery and mainly in the field of upper GI cancer surgery and its minimally invasive treatment. Broomfield Hospital is a high volume and the regional oesophagogastric cancer center in which more than 100 oesophagogastric resections per year are performed. I perform all types of oesophagectomies with the majority being laparoscopic assisted Ivor-Lewis oesophagogastrectomies and all the types of gastrectomies. Most of the elective operations I perform are laparoscopic. I perform upper GI and general surgical operations like laparoscopic incisional and inguinal (TEP and TAPP) hernia repair, laparoscopic cholecystectomy and CBD exploration, laparoscopic fundoplication, and laparoscopic Heller’s myotomy. I perform robotic upper GI surgery and especially robotic assisted Heller’s myotomy, robotic gastric resections and robotic gastric pacing. I also have a special interest in the treatment of gastroparesis and I am one of the two surgeons in the region who specializes in gastric pacing. I do general surgical on calls in a 1 in 8 rota. I perform upper GI diagnostic and therapeutic endoscopy and do upper GI and general surgical clinics. I am also a key member of the upper GI cancer MDT meetings.
As an Upper GI Surgeon I have been extensively trained in all types of oesophagectomies (Ivor-Lewis, McKeown, transhiatal, thoracoabdominal, minimal invasive), gastrectomies with extensive lymph node dissections (D1, D2 and even D3), bariatric surgery (gastric bypass, sleeve gastrectomy, gastric band, intragastric balloon) and laparoscopic benign upper GI disease. I have received expert training in Upper GI surgery from internationally renowned units. Specifically, cancer resections through fellowships from Broomfield Hospital in Chelmsford, National Cancer Centre Hospital in Tokyo, St Thomas’ Hospital in London and upper GI advanced laparoscopic procedures including bariatric surgery from St Thomas’ and St George’s Hospitals in London. I have also had advanced training in general surgery (mainly HPB, colorectal, endocrine, vascular) and was awarded an MSc and a PhD for my research in experimental acute pancreatitis and gastrointestinal carcinogenesis respectively. So far I have participated in about 3000 operations, the great majority of which is in the field of Upper GI surgery, having performed more than 1800 of those.
His research interests include: oesophagogastric cancer resection surgery, treatment of gastroparesis
1. Bariatric surgery. Operations and pitfalls. Chairman: Mr A Botha. FY2/CT/SHO Surgical Education Day. Guys and St Thomas Education Centre, London, UK. 07 Feb 2013
2. Complications of bariatric surgery. Round table. Chairman: Dr S Chong. South Thames Gut Club Meeting. Post Grad Lecture Theatre, St Helier Hospital. London, UK. 24 Nov 2011.
3. Round Table: The role of adhesion molecules in cancer. New useful tools. Topic: Cadherins. 15th Scientific Congress of Greek Medical School Students & 3rd International Forum of Medical Students and Young Doctors of Greece. Thessaloniki, Greece, 8-10 May 2009.
4. Surgical anatomy of the liver and types of hepatectomies. Higher Surgical Training Meeting of University of Athens. Attikon University Hospital, Athens, Greece. June 2009.
5. Respiratory failure and its prevention in the surgical patient. Higher Surgical Training Meeting of University of Athens. Attikon University Hospital, Athens, Greece. Feb 2008.
6. Oesophageal resection with colonic interposition. Round table. Chairman: Prof Liakakos. 1st Joined Meeting of the Travelling Surgical Society of Great Britain and Northern Ireland and the Third Academic Department of Surgery of the University of Athens. Attikon University Hospital, Athens, Greece. Sept 2008.
7. Spontaneous kidney rupture. A&E East Anglia Meeting. Peterborough Hospital, Peterborough, UK. April 2006.
8. Surgical pathology of liver and spleen. Basic Surgical Training Meeting. Post graduate center, Peterborough Hospital, Peterborough, UK. July 2005.
8. Surgical pathology of liver and spleen. Basic Surgical Training Meeting. Post graduate center, Peterborough Hospital, Peterborough, UK. July 2005.
9. Sore throat. ENT East Anglia Meeting. Peterborough Hospital, Peterborough, UK. Oct 2005.
10. Sensorineural hearing loss. ENT East Anglia Meeting. Peterborough Hospital, Peterborough, UK. Jan 2006.
11. Management of surgical infection. Basic Surgical Training Meeting. Post graduate center, Peterborough Hospital, Peterborough, UK. July 2005.
MEMBER OF COMMITTEES/SOCIETIES
Member of AUGIS - Association of Upper Gastrointestinal Surgeons of Great Britain & Ireland
Member of BOMMS - British Obesity & Metabolic Surgery Society
Member and Fellow of RCSEng - The Royal College of Surgeons of England
Member of EA-HPB-A - European-African Hepato-Pancreato-Biliary Association
Member of HPB-HS - The Hepato-Pancreato-Biliary Hellenic Society
PUBLICATIONS IN PEER REVIEWED INTERNATIONAL JOURNALS IN THE LAST 5 YEARS INCLUDE:
1. Charalabopoulos A, Golias C. E-cadherin expression in Barretts esophagus and esophageal carcinoma. Esophagus. 2014.
2. Charalabopoulos A, Lambropoulou M, Papalois A, Papachristou F, Simopoulos C, Tsaroucha A. Does apigenin exert a prophylactic effect in acute pancreatitis An experimental study evaluating pancreatic TNF- expression. J Surg Res. 2013.
3. Charalabopoulos A, Botha AJ. Laparoscopic cholecystectomy in the presence of lumboperitoneal shunt. Case Rep Surg. 2013; doi: 10.1155/2013/929082.
4. Machairas A, Tsapralis D, Samaras VD, et al. Basaloid squamous cell carcinoma of the rectum. A rare entity. J Med Cases. 2013; 4(8): 535-539.
5. Machairas A, Petropoulos K, Machairas N, Charalabopoulos A, Misiakos EP. Image of the month. Choledochocele. Arch Surg. 2011; 146(10): 1213-1214. doi: 10.1001/archsurg.2011.263-a.
6. Golias C, Batistatou A, Bablekos G, et al. Physiology and pathophysiology of selectins, integrins, and IgSF cell adhesion molecules focusing on inflammation. A paradigm model on infectious endocarditis. Cell Commun Adhes. 2011; 18(3): 19-32. doi: 10.3109/15419061.2011.606381.
7. Misiakos EP, Siama E, Schizas D, et al. Massive Uterine Leiomyoma in a Patient with Friedreichs Ataxia: Is There a Possible Association. Case Report Med. 2011; 2011:648217. doi: 10.1155/2011/648217.
8. Charalabopoulos K, Makris G, Charalabopoulos A, Golias C, Athanasiou K. Public knowledge, beliefs and practices in Greece about cancer etiology and prevention. East Mediterr Health J. 2011; 17(5): 392-397.
9. Charalabopoulos K, Krivan S, Machairas N, Misiakos A, Machairas EP. Endopancreatic bile duct cholangiocarcinoma in a patient with Peutz-Jeghers syndrome. HPB Surgery. 2011; 2011: 364570. doi: 10.1155/2011/364570.
10. Charalabopoulos K, Macheras N, Krivan S, Petropoulos K, Misiakos EP, Macheras A. Arteriovenous malformation of the pancreas. Case Reports Med. 2011; 2011: 612657.
11. Charalabopoulos A, Misiakos E, Macheras A. Colocutaneous fistula complicating sigmoid diverticulitis. Int J Surg Case Rep. 2011; 2: 68-70.
12. Batistatou A, Charalabopoulos A, Charalabopoulos K. Molecular basis of colorectal cancer. N Engl J Med. 2010; 362(13): 1246.
13. Tsapralis D, Charalabopoulos A, Karamitopoulou E, et al. Pancreatic intraductal papillary mucinous neoplasm with concomitant heterotopic pancreatic cystic neoplasia of the stomach: a case report and review of the literature. Diagn Pathol. 2010; 5: 4. doi: 10.1186/1746-1596-5-4.
14. Charalampopoulos A, Charalabopoulos A, Batistatou A, et al. Parathormone and 1,25(OH)2D3 but not 25(OH)D3 serum levels, in an inverse correlation, reveal an association with advanced stages of colorectal cancer. Clin Exp Med. 2010; 10(1): 69-72. doi: 10.1007/s10238-009-0069-6.
15. Charalabopoulos A, Misiakos EP, Foukas P, et al. Localized peripancreatic plasma cell Castleman disease. Am J Surg. 2010; 199(5): 51-3. doi: 10.1016/j.amjsurg.2009.05.020.
16. Yiotakis I, Georgolios A, Charalabopoulos A, et al. Primary localized laryngeal amyloidosis presenting with hoarseness and dysphagia: a case report. J Med Case Reports. 2009; 3: 9049. doi: 10.4076/1752-1947-3-9049.
17. Charalabopoulos K, Kotsalos A, Batistatou A, et al. Serum and tissue selenium levels in gastric cancer patients and correlation with CEA. Anticancer Res. 2009; 29(8):3465-7.
18. Batistatou A, Charalabopoulos A, Charalabopoulos K. Molecular basis of metastasis. N Engl J Med. 2009; 360(16): 1679. doi: 10.1056/NEJMra0805239.
19. Charalampopoulos A, Macheras A, Charalabopoulos A, Fotiadis C, Charalabopoulos K. Iliopsoas bscesses: diagnostic, aetiologic and therapeutic approach in five patients with a literature review. Scand J Gastroenterol. 2009; 44(5): 594-599. doi: 10.1080/00365520902745054. 20. Fareed KR, Charalabopoulos A. Minimally invasive oesophagectomy. Surg Res Open J. 2015; 2(1): e1-e2. doi: 10.17140/SROJ-2-e001
21. Rashid F, Charalabopoulos A. Laparoscopic gastrectomy for gastric cancer. Surg Res Open J. 2016; 3(1): e3-e5. doi: 10.17140/SROJ-3-e002
Lead of the Breast Unit
Assistant Professor in Breast and General Surgery
Department of Surgery
University of Athens
17 Agiou Thoma Street
11527, Athens, Greece
Dr Michalis Kontos graduated from the Medical School of the University of Athens in 1995. He completed his residency in General Surgery in Athens and he further specialised in Breast and Oncoplastic Surgery at Guy’s Hospital, London. He holds an MD on Lactamic Esters in the Treatment of Breast Cancer. He is now Lead of the Breast Unit and Assistant Professor in Breast and General Surgery at the 1st Department of Surgery of the University of Athens.
His clinical interests involve sentinel node biopsy, oncoplastic surgery and breast reconstruction. His research includes hormonal treatment in breast cancer including androgen receptors manipulation, early detection and treatment of reconstruction-related complications, psychological implications of breast cancer and breast cancer treatment and efficacy and safety of modern surgical devices.
His research includes hormonal treatment in breast cancer including androgen receptors manipulation, early detection and treatment of reconstruction-related complications, psychological implications of breast cancer and breast cancer treatment and efficacy and safety of modern surgical devices.
1. MD (Res), Lactamic Esters and Breast Cancer. University of Athens, Dec 2001 - Oct 2005: Laboratory study on the in vitro effect of lactamic esters of chlorambucil on fresh breast cancer tissue and breast cancer cell lines.
2. Scinigraphy of axillary lymphatics. Principal Investigator. University of Athens, 2010-2012. Clinical Trial on the preoperative lymphatic scintigrarhy in the detection of sentinel node in breast cancer patients.
3. TeraHertz Pulsed Imaging and breast cancer. Kings College London, Guys & St Thomas Foundation Trust, Apr 2007 - Jan 2008: Preclinical Study on the use of TeraHertz Pulsed Imaging for the intraoperative breast cancer detection.
4. Harmonic scalpel and breast surgery. Principal investigator: Guys & St Thomas Foundation Trust, Aug 2005 - Aug 2006: Clinical study on the use of Harmonic scalpel in and its impact on intraoperative and postoperative parameters.
5. Digtal Thermographic Imaging and breast cancer. Guys & St Thomas Foundation Trust, Jun 2006 - Jun 2007: Clinical study on the use of Digtal Thermographic Imaging in the diagnosis of breast cancer.
6. Radio Frequency Ablation. University of Athens, 2002-2005: Series of projects focusing on the use of the internally cooled radio frequency electrodes in haemostasis after solid organ injuries, laparoscopic liver resection and laparoscopic partial splenectomy.
7. Surgical Haemostatic Devices. University of Athens, 2002-2005: Study of efficacy and safety of haemostatic surgical instruments including monopolar and bipolar electrocoagulation, different models of electronically controlled bipolar electrocoagulation and different models of harmonic scalpel.
8. Small for Size Syndrome after Liver Resection and methods for reduction of Mortality and Morbidity. Principal Investigator. University of Athens, 23 September 2011 (approval date). Project in progress: Surgical experimental protocol on the liver failure observed after major liver resections and surgical methods of prevention.
9. Microwave assisted liver resection. Principal Investigator. University of Athens, 21 January 2009 (approval date). Experiment in progress: Microwave assisted parenchymal partial resection of solid organs.
1. Kontos M, Allen D, Trafalis DT, et al. Follow-up may not be beneficial after treatment of grade 1 breast cancer. Br J Surg. 2009; 96(9): 999-1004. doi: 10.1002/bjs.6669
2. Felekouras E, Kontos M, Kyriakou V, et al. Strongyloides Stercoralis Infection as a Cause of Acute Granulomatous Appendicitis in an HIV-positive Patient in Athens-Greece. Scand J Infect Dis. 2002; 34: 856-857. doi: 10.1080/0036554021000026943
3. Bramis J, Felekouras E, Kontos M, Leonardou P, Griniatsos J, Bastounis E. True giant common hepatic artery aneurysm associated with obstructive jaundice: a case report. Int Surg. 2002; 87: 142-146.
4. Kontos M, Fentiman IS. Adenoid Cystic Carcinoma of the Breast. Int J Clin Pract. 2003; 57: 669-672.
5. Felekouras E, Kontos M, Pissanou TH, et al. A new spleen preserving technique using radiofrequency ablation technology. J Trauma. 2004; 57: 1225-12259. doi: 10.1097/01.TA.0000145072.31725.52
6. Karamanakos P, Mitsiades C, Lembessis P, Kontos M, Trafalis D, Koutsilieris M. Male Breast Adenocarcinoma in a Prostate Cancer Patient Following Prolonged Anti-androgen Monotherapy. Anticancer Res. 2004; 24: 1077-1082.
7. Felekouras E, Kontos M, Pissanou TH, et al. Radio-frequency tissue ablation in liver trauma: an experimental study. Am Surg. 2004; 70: 989-993.
8. Trafalis D, Camoutsis C, Dalezis P, et al. Antitumor effect of an a- and d- lactam androgen nitrogen mustards on non-small cell lung carcinoma. J BUON. 2004; 9: 275-282.
9. Trafalis D, Chrysogeolou E, Dalezis P, et al. Octreotide neutralizes dexamethasone anti-tumor actions on P388 murine lymphocytic leukemia in vivo. J BUON. 2005; 10: 89-94.
10. Kontos M, Felekouras E, Drakos E, et al. Radio-frequency tissue ablation in an experimental grade IV renal trauma: A preliminary report. Surg Endosc. 2005; 19: 249-253. doi: 10.1007/s00464-003-9327-y
11. Pikoulis E, Felekouras E, Papaconstantinou J, et al. A novel spleen preserving laparoscopic technique using radio-frequency ablation in a porcine model. Surg Endosc. 2005; 19: 1329-1332. doi: 10.1007/s00464-004-2219-y
12. Felekouras E, Papaconstantinou I, Pikoulis E, et al. Laparoscopic liver resection using Radio Frequency Ablation (RFA) in a porcine model. Surg Endosc. 2005; 19: 1237-1242. doi: 10.1007/s00464-004-2260-x
13. Kontos M, Nikolopoulou M, Trafalis D, et al. The Effect of an Estrone d-Lactam Steroid Ester Derivative on Breast Cancer Cells and Its Predicted Binding Interactions with the Ligand Binding Domain of Estrogen Receptor-α Oncol Res. 2005; 16: 129-142. doi: http://dx.doi.org/10.3727/000000006783981161
14. Trafalis D, Geromichalos G, Bountouroglou N, et al. A preclinical survey of efficacy of Lactandrate in the treatment of colon carcinoma. J BUON. 2005; 10: 163-234.
15. Kontos M, Fentiman IS. Perioperative endocrine status and prognosis in early breast cancer. Breast J. 2006; 12: 518-525. doi: 10.1111/j.1524-4741.2006.00339.x
16. Filis K, Kontos M, Pikoulis E, Bakoyannis C, Leppaniemi A, Bastounis E. Expanding ulnar artery aneurysm presenting with signs of threatened rupture. Acta Chir Belg. 2006; 106: 101-103.
17. Diamantis T, Kontos M, Arvelakis A, et al. Comparison of monopolar electrocoagulation, bipolar electrocoagulation, Ultracision, and Ligasure. Surg Today. 2006; 36: 908-913. doi: 10.1007/s00595-006-3254-1
18. Felekouras E, Prassas E, Kontos M, et al. Liver Tissue Dissection: Ultrasonic or RFA Energy? W J Surg. 2006; 30: 2210-2216. doi: 10.1007/s00268-005-0468-0
19. Papaconstantinou I, Kontos M, Prassas E, et al. Radio frequency ablation (RFA)-assisted pericystectomy for hepatic echinococcosis: an alternative technique. Surg Laparosc Endosc Percutan Tech. 2006; 16: 338-341. doi: 10.1097/01.sle.0000213702.56569.3f
20. Kalahanis N, Pikoulis E, Kontos M, et al. Erhaltung der vorhandenen Colostomie bei Reoperation des Dickdarms. How I do it. Zentralbl Chir. 2007; 132: 151-154.
21. Kontos M, Hamed H. Why individualize breast cancer survivors follow-up? J BUON. 2007; 12(4): 553-554.
22. Kontos M, Felekouras E, Fentiman IS. Radiofrequency ablation in the treatment of primary breast cancer: no surgical redundancies yet. Int J Clin Pract. 2008; 62(5): 816-820. doi: 10.1111/j.1742-1241.2007.01676.x
23. Felekouras E, Argyriadis-Roussos L, Kontos M, Michail O, Pikoulis E, Papalambros E. Intermittent Pringle manoeuvre in interhospital transfer for liver trauma. ANZ J Surg. 2008; 78(7): 620. doi: 10.1111/j.1445-2197.2008.04590.x
24. Diamantis T, Gialikaris S, Kontos M, et al. Comparison of safety and efficacy of ultrasonic and bipolar thermal energy: an experimental study. Surg Laparosc Endosc Percutan Tech. 2008; 18(4): 384-390. doi: 10.1097/SLE.0b013e31816f85c9.
25. Kontos M, Kothari A, Hamed H. Effect of Harmonic Scalpel on seroma formation following surgery for breast cancer: a prospective randomized study. J BUON. 2008; 13(2): 223-230.
26. Kontos M, Petrou A, Prassas E, et al. Pressure dressing in breast surgery: is this the solution for seroma formation? J BUON. 2008; 13(1): 65-67.
27. Kontos M, Fentiman IS. Systemic lupus erythematosus and breast cancer. Breast J. 2008; 14(1): 81-86. doi: 10.1111/j.1524-4741.2007.00520.x
28. Tomos P, Felekouras E, Poupalou A, et al. Video-assisted lung resection using radiofrequency ablation in a porcine model. J Surg Res. 2009; 154(2): 279-283. doi: 10.1016/j.jss.2008.06.011
29. Lewis RS, Kontos M. Autologous tissue immediate breast reconstruction: desired but oncologically safe? Int J Clin Pract. 2009; 63(11): 1642-1646. doi: 10.1111/j.1742-1241.2009.02199.x
30. Kontos M, Lewis Rs, Luchtenborg M, Holmberg L, Hamed H. Does immediate breast reconstruction using free flaps lead to delay in the administration of adjuvant chemotherapy for breast cancer? Eur J Surg Oncol. 2010; 36(8): 745-749.doi: 10.1016/j.ejso.2010.06.013
31. Pappas Pc, Kontos M. New intraoperative gamma camera for the sentinel lymph node localization in breast cancer. From radio to TV? J BUON. 2010; 15(2): 396-397.
32. Kontos M, Agbaje Of, Rymer J, Fentiman IS. What can be done about hot flushes after treatment for breast cancer? Climacteric. 2010; 13(1): 4-21. doi: 10.3109/13697130903291058
33. Staikou C, Paraskeva A, Drakos E, et al. Impact of graded hypothermia on coagulation and fibrinolysis. J Surg Res. 2011; 167(1): 125-130. doi: 10.1016/j.jss.2009.07.037
34. Geromichalos Gd, Geromichalou E, Camoutsis C, et al. In silico/in vitro study of hybrid D-modified steroidal alkylator anticancer activity using uridine phosphorylase as target protein. Anticancer Res. 2011; 31(3): 831-842.
35. Kontos M, Roy P, Rizos D, Hamed H. An evidence based strategy for follow up after breast conserving treatment for breast cancer. J Surg Oncol. 2011; 104(3): 223-227. doi: 10.1002/jso.21747
36. Staikou C, Paraskeval A, Donta I, Theodossopoulos T, Anastassopoulou I, Kontos M. The effects of mild hypothermia on coagulation tests and haemodynamic variables in anaesthetized rabbits. West Indian Med J. 2011; 60(5): 513-518.
37. Kontos M, Allen Ds, Agbaje Of, Hamed H, Fentiman IS. Factors influencing loco-regional relapse in older breast cancer patients treated with tumour resection and tamoxifen. Eur J Surg Oncol. 2011; 37(12): 1051-1058. doi: 10.1016/j.ejso.2011.07.005
38. Kontos M, Wilson R, Fentiman I. Digital infrared thermal imaging (DITI) of breast lesions: sensitivity and specificity of detection of primary breast cancers. Clin Radiol. 2011; 66(6): 536-539. doi: 10.1016/j.crad.2011.01.009
39. Pazaiti A, Kontos M, Fentiman IS. ZEN and the art of breast health maintenance. Int J Clin Pract. 2012; 66(1): 28-36. doi: 10.1111/j.1742-1241.2011.02805.x
40. Petrou A, Kontos M, Prassas E, et al. The three-surgeon technique for liver tissue dissection: towards real bloodless hepatectomy. J BUON. 2012; 17(2): 304-309.
41. Manzelli A, Quaresima S, Rossi P, et al. Solitary skin metastasis from sarcomatoid carcinoma of the bladder: a case report. J Med Case Rep. 2011; 5: 484. doi: 10.1186/1752-1947-5-484
42. Kontos M, Karles D, Petrou A, Alexandrou PT. Adenoid cystic carcinoma intermingled with ductal carcinoma of the breast: a case report and review of the literature. J Med Case Rep. 2011; 5(1): 437. doi: 10.1186/PREACCEPT-1913808182507613.
43. Petrou A, Alexandrou P, Papalambros A, et al. A Malignant Gastrointestinal Stromal Tumor of the Gallbladder Immunoreactive for PDGFRA and Negative for CD 117 Antigen (c-KIT). HPB Surg. 2011; 2011: 327192. doi: http://dx.doi.org/10.1155/2011/327192
Clinical Assistant Professor of Surgery and Dentistry
Undergraduate Clinic Director
Department of Oral and Maxillofacial Surgery
University of Michigan School of Dentistry
1011 N. University Ave.
Ann Arbor, MI 48109, USA
Education and Training
- High School Graduation: June 1969 (Grade: “Very Good”)
-University of Athens School of Dentistry (1970-1976). Graduation: July 1976 (Grade: “Very Good”), Degree: DMD
- PhD Degree: Field: Pathology, Institution: University of Athens School of Dentistry, degree conferred in May, 1985 (Grade: “Excellent”)
- Private practice of Dentistry: August 1976 – October 1976
- Residency in Oral Pathology, University of Athens School of Dentistry, Department of Oral Pathology (October 1976 – October 1979)
- Private practice of Dentistry/Oral Medicine/Pathology: November 1979– January 1980
- Military Service: January 1980 – March 1982. Branch: Greek Navy. Location: Athens Naval Hospital. Rank: Petty Officer. Department of Otolaryngology (Intern: 18 months), Department of Dentistry (House officer: 6 months). Present status: Former active duty reserve.
- Private practice of Dentistry/Oral Medicine/Pathology: March 1982 – May 1982
- Residency: University of Pittsburgh School of Medicine/Presbyterian-University Hospital, Department of Oral and Maxillofacial Surgery. Start: July 1, 1982. Completion: June 30, 1988 (Alumnus Pittsburgh Plastic Surgery Program)
- Teaching Fellowship: University of Pittsburgh School of Dental Medicine, Oral and Maxillofacial Surgery. Start: July 1, 1988. Completion: June 30, 1989
-Privatepractice of Oral and Maxillofacial Surgery (11/1992-12/1995 and 12/2004 –5/2011)
Academic, Administrative, and Clinical Appointments
- Assistant Professor of Oral and Maxillofacial Surgery with tenure, Division of Neurology and Sensory Organs, Department of Otolaryngology/Head and Neck Surgery, University of Crete School of Medicine, Crete, Greece, 6/1992 – 9/1996
- Associate Professor of Oral and Maxillofacial Surgery with tenure, University of Athens School of Dentistry, 9/1996 – 5/2011
- Clinical Assistant Professor, Department of Surgery, Section of Oral and Maxillofacial Surgery, University of Michigan School of Medicine (2011-present)
- Clinical Assistant Professor, Department of Oral and Maxillofacial Surgery, University of Michigan School of Dentistry (2012-present)
Coordinator, Outpatient Clinic, Department of Oral and Maxillofacial Surgery, University of Athens School of Dentistry (8/2004-5/2011)
- Senior Registrar and Acting Head, Department of Oral and Maxillofacial Surgery, University Hospital of Heraklion, Crete, Greece (10/1989 – 12/1989)
- Senior Registrar, Department of Oral and Maxillofacial Surgery, University Hospital of Heraklion, Crete, Greece (01/1990 – 6/1992)
- Director, Microsurgery Laboratory, Division of Neurology and Sensory Organs, University of Crete School of Medicine, Crete, Greece (6/1992-9/1996)
- Director of Resident Training, Department of Oral and Maxillofacial Surgery, Evangelismos General Hospital, Athens, Greece (9/1996-12/1999)
- Co-Director, Department of Oral and Maxillofacial Surgery, Evangelismos General Hospital, Athens, Greece (12/1999-7/2004)
- Director, Oral and Maxillofacial Surgical Service, The AthensEuroclinic, Athens, Greece (1/2005-4/2011)
- Undergraduate Clinic Director, Department of Oral and Maxillofacial Surgery, University of Michigan School of Dentistry (2012-present)
1. Correlation of serum IgA, IgG, IgM, and complement C3 with the clinical and histological characteristics of oral squamous carcinoma on the basis of the STNMP system (PhD Dissertation).
2. Lymphatic mapping and sentinel node biopsy in oral squamous cell carcinoma.
3. Malignant tumors of the head and neck: radionuclide scanning in the assessment of distant osseous metastases.
4. Comparative study of bromazepamvs.bromazepam plus meperidine hydrochloride in preoperative anxiolysis.
5. Comparative study of lornoxicamvs.nimesulide in postoperative analgesia in third molar surgery under local anesthesia.
6. Mandibular radiomorphometric measurements as indicators of possible osteoporosis in postmenopausal women.
7. Relationship between BMD, dental panoramic radiographic findings and biochemical markers of bone turnover in diagnosis of osteoporosis.
8. Relationship between BMD, dental panoramic radiographic findings and biochemical markers of bone turnover in diagnosis of osteoporosis.
9. Histopathologic study of the carotid sheath in patients with oral squamous cell carcinoma.
Memberships in Professional Societies
Member, Hellenic Association for Oral and Maxillofacial Surgery (since 1979)
- Founding Member, Greek Society of Osseointegration (since 1998)
- Founding Member, Hellenic Association of Dento-Maxillofacial Radiology (since 2000)
- Member, Hellenic-American Medical Association (since 1995)
- Member, Greek Stomatological Society (since 1978)
- Member, Greek Society of Oral Pathology (since 2001)
- Member, Hellenic Association for Minimally Invasive Facial Rejuvenation (since 2008)
- Affiliate Member, American Association of Oral and Maxillofacial Surgeons (1990-2013)
- Faculty Member, American Association of Oral and Maxillofacial Surgeons (since 2013)
- Fellow, American College of Oral and Maxillofacial Surgeons (since 2003)
- Fellow, International Association of Oral and Maxillofacial Surgeons (since 2003)
- Member, European Association for Cranio-Maxillofacial Surgery (since 1990)
- Member, International College for Maxillofacial Surgery (since 1988)
- Member, International Cleft Palate Foundation (since 2004)
- Member, American Academy of Cosmetic Surgery (since 2008)
- Founding Member, Balkan Association of Maxillofacial Surgeons (since 2009)
- Member, C.J. Lyons Academy, Michigan (since 2013)
-Member, Detroit Academy of Oral and Maxillofacial Surgeons (since 2013)
- Member, International Association of Oral Oncology (since 2013)
- Member, Michigan Society of Oral and Maxillofacial Surgeons (since 2014)
- Faculty Member of Alpha Omega Dental Fraternity (Detroit Chapter-since 2012)
Committee, Organizational, and Volunteer Service
- Member, Committee for the restructuring of the dental curriculum, University of Athens School of Dentistry (2001)
- Member of Selection Committees for New Faculty Appointments and Faculty Development (University of Crete School of Medicine, University of Athens School of Dentistry, University of Ioannina School of Medicine, and University of Thessaloniki School of Dentistry)
- Member of 25 PhD Dissertation Committees: University of Athens School of Dentistry: 15, University of Athens School of Medicine: 2, University of Crete School of Medicine: 6
- Curriculum Committee, University of Michigan School of Dentistry, Ann Arbor, MI
- Discipline Coordinator for Oral Surgery, University of Michigan School of Dentistry, Ann Arbor, MI
- Quality Assurance Committee, University of Michigan School of Dentistry, Ann Arbor, MI
- Coordinator, Scientific Committee, Dental Association of Heraklion-Lasithi, Crete (1992)
- Member, Dental Disciplinary Board for the region of Crete (1993-1995)
- Member, Committee for the Evaluation and Selection of Medical and Dental Hospital Staff (Oral and Maxillofacial Surgery), Attiki Region, Greece (1998)
- Member, Committee for the Evaluation and Selection of Medical and Dental Hospital Staff (Oral and Maxillofacial Surgery), Attiki Region (2000)
- Member, National Committee of Oral and Maxillofacial Surgery, Ministry of Health (1991-1994)
- Member, Hellenic Board of Oral and Maxillofacial Surgery (1998-1999)
- Member, Scientific Committee of the Hellenic Dental Association (1998-2004)
- Vice President, Hellenic Association for Oral and Maxillofacial Surgery (1996-1999, 2003-2005)
- Special Secretary, Hellenic Association for Oral and Maxillofacial Surgery (1999-2002)
- President, Greek Association for the Study of Clefts and Facial Deformities (2006-2007)
- Secretary General, Balkan Association of Maxillofacial Surgeons (2009-2011)
HSDA Volunteer, Community Clinic of Migrant Farm Workers, Adrian MI, August 13th and August 14th 2014
- Coordinator of the didactic activities of the Department of Oral and Maxillofacial Surgery, University of Pittsburgh School of Medicine-Presbyterian University Hospital during my Teaching Fellowship (1988-1989)
- Active participation in the organization of the Department of Oral and Maxillofacial Surgery, University Hospital of Heraklion, Crete (1989)
- Coordinator of progress, mid-term, and final student examinations, Department of Oral and Maxillofacial Surgery, University of Athens School of Dentistry (1997-2002)
- Active participation in the renovation and re-organization of the Outpatient Clinic, Department of Oral and Maxillofacial Surgery, University of Athens School of Dentistry, Evangelismos General Hospital (1997)
- Active participation in the organization of the Outpatient Laser Surgery Service, Department of Oral and Maxillofacial Surgery, University of Athens School of Dentistry (1998)
- Coordinator of resident operating room instruction and didactic courses,Department of Oral and Maxillofacial Surgery, University of Athens School of Dentistry, Evangelismos General Hospital (1998-2002)
- Introduction and organization of the Resident’s Forum (meeting in which residents from Greek OMS training programs present topics covering the entire spectrum of oral and maxillofacial surgery) (1998-1999)
- Member, Organizing Committee, 11th Annual Congress of the Hellenic Association for Oral and Maxillofacial Surgery, Athens, Greece, November 21-23, 1997
- President, Organizing Committee, 12th Annual Congress of the Hellenic Association for Oral and Maxillofacial Surgery, Athens, Greece, November 20-22, 1998
- Member, Organizing Committee, 16th Annual Congress of the Hellenic Association for Oral and Maxillofacial Surgery, Athens, Greece, November 29-December 1, 2002
- Secretary General, 16th International Conference on Oral and Maxillofacial Surgery, International Association of Oral and Maxillofacial Surgeons, Athens, May 14-16, 2003
Visiting Professorships, Seminars, and Extramural Invited Presentations
- Visiting Professor in Maxillofacial Surgery, Department of Plastic, Reconstructive and Oral and Maxillofacial Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, March 11-30, 1990. Lectures to the undergraduate and graduate dental students.
- Visiting Professor, Department of Head and Neck / Maxillofacial Surgery, Greek Anticancer Institute, Saint Savvas Hospital. Clinical and educational duties (large number of operations covering the entire spectrum of Oral and Maxillofacial Surgery, Head and Neck Surgery and Plastic and Reconstructive Surgery of the face (01/01/1996 – 12/31/1997).
- Visiting Professor, Department of Oral and Maxillofacial Surgery, Virginia Commonwealth University, Richmond, VA, October 12, 2006. Lecture: Essential Facial Esthetic Considerations in Orthognathic Surgery.
- Visiting Professor, Department of Oral and Maxillofacial Surgery, Virginia Commonwealth University, Richmond, VA, July 2, 2007. Didactic activity: Clinicopathologic Conference.
- Visiting Professor, Department of Oral and Maxillofacial Surgery, Virginia Commonwealth University, Richmond, VA, June 16 – June 28, 2008. Lectures: 1) Salivary Gland Surgery, 2) Q & A’s in Oral Cancer Diagnosis and Management, 3) Surgical Management of Soft Tissue Cysts and Pseudocysts of the Orofacial and Neck Region.
- Visiting Professor, Department of Oral and Maxillofacial Surgery, Virginia Commonwealth University, Richmond, VA, September 4 – September 16, 2009. Lecture: Favorable and Unfavorable Effects of Maxillary Advancement on Nasal Esthetics.
- Visiting Professor, Department of Oral and Maxillofacial Surgery, Virginia Commonwealth University, Richmond, VA, July25 – July 28, 2010. Lecture:Anatomy and Clinical Application of the Buccal Fat Pad.
- Surgical Clinic Presentation, 84th Annual Meeting, Scientific Sessions, and Exhibition, American Association of Oral and Maxillofacial Surgeons, October 2-5, 2002, Chicago, Illinois. Topic: Soft Tissue Closure Techniques in Alveolar Cleft Grafting. Overall seminar rating: 3.73/4.00
- Surgical Clinic Presentation, 85th Annual Meeting, Scientific Sessions, and Exhibition, American Association of Oral and Maxillofacial Surgeons, September 10-13, 2003, Orlando, Florida. Topic: Soft Tissue Closure Techniques in Alveolar Cleft Grafting. Overall seminar rating: 3.90/4.00
- Surgical Clinic Presentation, 86th Annual Meeting, Scientific Sessions, and Exhibition, American Association of Oral and Maxillofacial Surgeons, September 29-October 2,2004, San Francisco, California. Topic: Soft Tissue Closure Techniques in Alveolar Cleft Grafting. Overall seminar rating: 3.62/4.00
- Surgical Clinic Presentation, 88th Annual Meeting, Scientific Sessions, and Exhibition, American Association of Oral and Maxillofacial Surgeons, October 3-7, 2006, San Diego, California. Topic: Surgical Management of Soft Tissue Cysts and Pseudocysts of the Orofacial and Neck Region. Overall seminar rating: 3.00/4.00
- Refresher Course Presentation in the upcoming 96th Annual Meeting, Scientific Sessions, and Exhibition, American Association of Oral and Maxillofacial Surgeons, September 8-13, 2014, San Diego, California. Topic: Soft Tissue Cysts and Pseudocysts of the Facial Skin, Oral Cavity, and Neck.
Extramural Invited resentations
- Department of Oral and Maxillofacial Surgery, Queen Mary’s Hospital, Roehampton, England, July 19, 1978. Presentation: Benign and Malignant Tumors of the Salivary Glands.
- Division of Plastic and Maxillofacial Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, October 14 -25, 1991. Lectures to the oral and maxillofacial surgery residents.
- Division of Plastic and Maxillofacial Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, May 22, 1993. Lecture: Aesthetic Unit Reconstruction of the Upper Lip.
- Department of Oral and Maxillofacial Surgery, Virginia Commonwealth University, Richmond, VA, May 20-21, 1993. Presentations: 1) Reconstruction of the Upper and Lower Lip and 2) Surgery of the Parotid Gland.
- Department of Oral and Maxillofacial Surgery, Tufts University, Boston, MA, September 11, 1997. Presentation: Salivary Gland Tumors: Diagnosis and Surgical Treatment.
- 3rd Biennial World Congress of the International Cleft Lip and Palate Foundation, Halifax, Nova Scotia, Canada, June 22-26, 2004. “Meet the Experts” panelist. Presentation: Alveolar Cleft Repair: Management of Concomitant Soft Tissue Problems.
- Department of Oral and Maxillofacial Surgery, Tufts University, Boston, MA, October 15, 2003. Course Director. Presentation: Repair of Alveolar Clefts.
- 1st International Oral and Maxillofacial Surgery Congress, Antalya, Turkey, May 16-20, 2007. Presentation: Essential Esthetic Considerations in Orthognathic Surgery.
- 2ndInternational Oral and Maxillofacial Surgery Congress, Antalya, Turkey, May 16-20, 2008. Presentation: Soft Tissue Cysts of the Neck: Natural History and Management.
- XII Congress of the Serbian Association of Maxillofacial Surgeons, Belgrade, Serbia, October 22-25, 2008. Presentation: Alveolar Cleft Repair: An Overview of Osseous and Soft Tissue Management.
- 25th Anniversary Scientific Meeting, American Academy of Cosmetic Surgery, Phoenix, AZ, January 15-18, 2009. Presentation: Favorable and Unfavorable Effects of Maxillary Advancement on Nasal Esthetics.
-3rdInternational Oral and Maxillofacial Surgery Congress, Antalya, Turkey, April 22-26, 2009. Presentation: Oral Cancer: Diagnostic Work-up and Surgical Management of the Unknown Primary.
- Yeditepe University Faculty of Dentistry, Istanbul, Turkey, June 18, 2009. Presentation: Current Management of Avulsed Teeth.
- 10th Alexandria International Cranio-Maxillo-Facial and Plastic Surgery Congress, Alexandria, Egypt, December 16-18, 2009. Presentations: 1) The Role of Sentinel Node in Oral Cancer, 2) Soft Tissue Management in Alveolar Cleft Grafting.
- 4th International Oral and Maxillofacial Surgery Congress, Antalya, Turkey, May 26-30, 2010. Presentation: The Use of Temporalis Flap for Oral Reconstruction.
- 25th Congress of the International College for Maxillofacial Surgery, Belgrade, Serbia, October 27-30, 2010. Presentation: The Buccal Fat Pad: Anatomy and Clinical Applications.
-Joint Meeting of the Corfu Medical Association, Corfu Dental Association, and Corfu Medical-Surgical Association, 5/7/2011, Corfu , Greece (Theme: New trends in Head and Neck Reconstruction). Presentation: Surgical Treatment of Oral Cancer.
- 5th International Oral and Maxillofacial Surgery Congress, Antalya, Turkey, May 25-29, 2011. Presentation:Orofacial econstruction: Regional flaps revisited.
- 25th Annual Congress of the Hellenic Association for Oral and Maxillofacial Surgery, Athens, Greece, November 25-27, 2011. Presentation: Carcinoma of Unknown Primary of the Head and Neck: Diagnosis and Management.
- 93rd Annual Meeting, Scientific Sessions, and Exhibition, American Association of Oral and Maxillofacial Surgeons, September 11-17, 2011, Philadelphia, Pennsylvania. Topic: Oral Cancer and the Sentinel Node: A Clinicopathologic Study (Poster presentation)
- Synthes Nursing Continuing Education, Principles of Craniomaxillofacial Trauma and Reconstruction for Operating Room Personnel, Dearborn, MI, November 3, 2012. Topics: 1. The Biology of Fracture Healing-Introduction to Stable Internal Fixation of the Facial Skeleton, 2. Mandibular Reconstruction.
- “Assistentium Seminars”, Department of Cranio-Maxillofacial and Oral Surgery, Medical University of Vienna, Austria, December 5, 2012. Topic: Regional Flaps Revisited.
- UoM/Delta Dental Seminar, Medical Considerations for the Dental Patient-Medical Emergencies in the Dental Office, 9/27/2013, Gaylord, MI.
- Combined OMFS Grand Rounds, Harvard/BU/Tufts. Topic: Regional Flaps Revisited: Is there any place for these flaps in the era of free flap reconstruction? 2/5/2014 Boston, MA.
- UoM/Delta Dental Seminar, Medical Considerations for the Dental Patient-Medical Emergencies in the Dental Office, October 17, 2014, Novi, MI
Peer-Reviewed Journals and Publications
1. Rapidis AD, Angelopoulos AP, Langdon JD, Skouteris CA. Computerized Axial Tomography in the Diagnosis of Head and Neck Tumors. Int J Oral Surg. 1980; 9(7): 387. doi: 10.1016/S0300-9785(80)80065-2
2. Rapidis AD, Angelopoulos AP, Scouteris CA. Dermoid Cyst of the Floor of the Mouth. Report of a Case. Bt J Oral Surg. 1981; 19(38): 43. doi: http://dx. doi.org/10.1155/2011/362170
3. Scouteris CA, Rapidis AD, Angelopoulos AP, Langdon JD. Freys Syndrome. Oral Surg. 1981; 52(6): 368.
4. Rapidis AD, Angelopoulos AP, Skouteris CA, Papanicolaou S. Mural (Intracystic) Ameloblastoma. Int J Oral Surg. 1982; 11(18): 166. doi: 10.1016/S0300-9785(82)80004-5
5. Laskaris G, Skouteris CA. Maffuccis Syndrome: Report of a Case with Oral Hemangiomas. Oral Surg. 1984; 57(25): 263. doi: 10.1016/0030-4220(84)90181-6
6. Skouteris CA, Sotereanos GC. Plunging Ranula. Report of a Case. J Oral Maxillo fac Surg. 1987; 45(14): 1068.
7. Skouteris CA, Sotereanos GC. Closure of the Vestibular Oronasal Communications in Cleft Patients. A Retrospective Study. J Oral Maxillofac Surg. 1987; 45(2): M9.
8. Skouteris CA, Sotereanos GC. Secondary Acquired ConjunctivalMelanosis Resulting from an Alloplastic Implant. J Oral Maxillofac Surg. 1988; 46(5): 603-605. doi: http://dx.doi.org/10.1016/0278-2391(88)90152-8
9. Skouteris CA. Fiberoptic Endoscopy of a MarsupializedDentigerous Cyst. J Oral Maxillofac Surg. 1988; 46(1): 74. doi: http://dx.doi.org/10.1016/0278-2391(88)90305-9
10. Skouteris CA, Sotereanos GC. Solitary Neurofibroma of the Maxilla. Report of a Case. J Oral Maxillofac Surg. 1988; 46(17): 70. doi: http://dx.doi.org/10.1016/0278-2391(88)90117-6
11. Skouteris CA, Sotereanos GC. Parotid Mass in a Patient with von Recklinghausens Disease. J Oral MaxillofacSurg. 1989; 47(1): 495. doi: http://dx.doi.org/10.1016/0278-2391(89)90283-8
12. Skouteris CA, Sotereanos GC. Donor Site Morbidity Following Harvesting of Autogenous Rib Grafts. J Oral Maxillofac Surg. 1989; 47(54): 808-812. doi: 10.1016/S0278-2391(89)80038-2
13. Skouteris CA, Patterson G, Sotereanos GC. Benign Cervical Lymphoepithelial Cysts. Report of Cases. J Oral Maxillofac Surg. 1989; 47(11): 1106-1112. doi: 10.1016/0278-2391(89)90194-8
14. Georgiadis A, Segas J, KavvalosG, et al. Temperature Changes Using Excimer Laser Irradiation in a Cochlear Model. Lasers in Medical Science. 1993; 8(8): 22. doi: 10.1007/BF02547879
15. Skouteris CA. Setting the record straight. J Oral Maxillofac Surg. 1994; 52: 431-432.
16. Skouteris CA. More on hemangiomas in patients with Maffuccis syndrome. J Oral Maxillofac Surg. 1994; 52(1): 205. doi: http://dx.doi.org/10.1016/0278-2391(94)90428-6
17. Skouteris CA. Incidence of SoliteryIntraosseous Neurofibroma of the Maxilla. J Oral Maxillofac Surg. 1994; 52(4): 205. doi: http://dx.doi.org/10.1016/0278-2391(94)90430-8
18. Skouteris CA, Velegrakis G, Christodoulou P, Helidonis E. Infantile Osteomyelitis of the Maxilla with Concomitant Subperiosteal Orbital Abscess. A Case Report. J Oral MaxillofacSurg. 1995; 53(9): 67. doi: http://dx.doi.org/10.1016/0278-2391(95)90505-7
19. Rapidis AD, Archondakis G, Anteriotis D, Skouteris CA. Chondrosarcomas of the Skull Base. Review of the Literature and Report of two Cases. J Craniomaxillofac Surg. 1997; 25(31): 322.
20. Skouteris CA. Keeping the record straight. J Oral Maxillofac Surg. 1998; 56: 907.
21. Rapidis AD, Valsamis S, Anterriotis D, Skouteris CA. Functional and aesthetic results of various lip-splitting incisions: A clinical analysis of 60 cases *. J Oral Maxillofac Surg. 2001; 59(14): 1292. doi: 10.1053/joms.2001.27517
22. Skouteris CA, Mylonas AI, Galanaki EJ, Angelopoulos AP. Acute Bronchial Obstruction AfterNasotracheal Intubation.Report of a Case. J Oral Maxillofac Surg. 2002; 60(2): 1188. doi: http://dx.doi.org/10.1053/joms.2002.35031
23. Landa LE, Tartan BF, Aguz A, Skouteris CA, Gordon C, Sotereanos GC. The transcervical incision for use in oral and maxillofacial surgical procedures. J Oral Maxillofac Surg. 2003; 61(3): 343-346. doi: 10.1053/joms.2003.50035
24. Marti K, Skouteris CA, Mylonas AI, Angelopoulos AP, Morgan TA. Large preauricular swelling in a 75-year-old woman. Oral Maxillofac Surg. 2004; 62(1): 730. doi: 10.1016/j.joms.2003.09.013
25. Papadogeorgakis N, Skouteris CA, Mylonas AI, Angelopoulos AP. Superficial parotidectomy. technical modifications based on tumour characteristics. J Craniomaxillofac Surg. 2004; 32(19): 350. doi: http://dx.doi.org/10.1016/j.jcms.2004.05.004
26. Vlasiadis ZK, Skouteris CA, Velegrakis GA, et al. Mandibular radiomorphometric measurements as indicators of possible osteoporosis in postmenopausal women. Maturitas. 2007; 58(35): 226.
27. Vlasiadis KZ, Damilakis J, Velegrakis GA, et al. Relationship between BMD, dental panoramic radiographic findings and biochemical markers of bone turnover in diagnosis of osteoporosis. Maturitas. 2008; 59(32): 226. doi: 10.1016/j.maturitas.2008.01.006
28. Mylonas AI, Skouteris CA, Vretakos G, Petraki C. Cryptogenic Stroke and Parotid Tumor Surgery. A Case Report. J Oral Maxillofac Surg. 2010; 68: 1205. doi: 10.1016/j.joms.2009.08.015
29. Kolomvos N, Skouteris CA,Papadogeorgakis N, Sklavounou, A, Alexandridis C, Angelopoulos AP. Histopathologic study of the carotid sheath in patients with oral squamous cell carcinoma. J Oral Maxillofac Surg. 2010; 68(1): 2452. doi: 10.1016/j.joms.2009.10.011
30. Mylonas AI, Poulakou-Rebelakou EF, Androutsos GI, Seggas J, Skouteris CA, a Chr. Papadopoulou EC. Oral and cranio-maxillofacial surgery in Byzantium, Original Research Article. J Cranio-Max-fac Surg. 2014; 42: 159.
31. Marti K, Skouteris C. The Art and Science of Coronectomy. Oral and Maxillofacial Surgery. 2014; 22.
Diplomate of the American Board of Plastic Surgery Medical Director at Lincoln Park Aesthetics Director of Aesthetic Surgery for NSPS
Northwestern Specialists in Plastic Surgery, S.C.
676 North Saint Clair Street, Suite 1525A
Chicago, IL 60611, USA
Dr. Clark Friedrich Schierle is a board certified Chicago plastic surgeon specializing in aesthetic and reconstructive surgery of the face, breast and body. He received his undergraduate degree from the University of California, Los Angeles (UCLA), where he began as a full-time student at the precocious age of twelve. After completing a postgraduate research fellowship in Microbiology & Molecular Genetics, he spent the next ten years earning a PhD in the same subject as well as a MD, both from Harvard University in Boston, Massachusetts.
Dr. Schierle completed his training in plastic surgery in Chicago, IL, at the prestigious seven year Integrated Plastic Surgery Residency program at Northwestern University in Chicago, Illinois, where he received extensive training in cosmetic and reconstructive surgery of the face, breast and body. He has trained and worked extensively with surgeons from Northwestern Memorial Hospital, Childrens Memorial Hospital, NorthShore University HealthSystem including Evanston, Glenbrook and Highland Park Hospitals, Chicagos Shriners Hospital, and the Chicago Center for the Surgery of the Hand.
His research interests include: three-dimensional imaging for plastic surgery, endoscopic breast augmentation, wound healing, scarring, lower extremity reconstruction, cosmetic breast surgery, non-surgical treatments for aging, and face transplantation.
Dr. Schierles work in advancing both the cosmetic and reconstructive aspects of Plastic Surgery has been nationally recognized by awards from both the Wound Healing Society and the American Society for Aesthetic Plastic Surgery. He has been asked to present at national and international meetings such as the American Society of Plastic Surgeons, the American Society for Aesthetic Plastic Surgery, the American Society for Reconstructive Microsurgery, the Chinese Society of Plastic Surgeons, and the Association of Organ Procurement Organizations. He has lectured on topics as diverse as three-dimensional imaging for plastic surgery, endoscopic breast augmentation, wound healing, scarring, lower extremity reconstruction, cosmetic breast surgery, non-surgical treatments for aging, and face transplantation. Dr. Schierle has authored numerous articles in peer-reviewed journals, including Plastic & Reconstructive Surgery, Journal of Reconstructive Microsurgery, Journal of Trauma, Wound Repair & Regeneration and the Aesthetic Surgery Journal, as well as book chapters for authoritative texts on cosmetic and reconstructive procedures such as Practical Plastic Surgery, Cosmetic Bootcamp Primer, and Plastic and Reconstructive Surgery Board Review.
1. Schierle CF, Tresley J, Rosenberg D, Casas LA. Improving outcomes of vertical reduction mammaplasty: Quantitative analysis of the learning curve in the first 100 consecutive cases by a single surgeon. Plastic and Reconstructive Surgery.
2. Schierle CF, Kalainov D. Suprascapular nerve entrapment in the setting of modified Weaver-Dunn acromioclavicular joint reconstruction: a case report and review of the literature. Journal of Bone and Joint Surgery.
3. Schierle CF, OShaughnessy K, Ding XZ, Skaliter R, Galiano RD, Mustoe TA. Modulation of epidermal gene expression by silicone gel occlusion in a novel murine cutaneous wound model. Wound Repair and Regeneration.
4. Schierle CF, De la Garza M, Galiano RD, Mustoe TA. Diabetic wounds are more susceptible to delayed reepithelialization by the presence of a bacterial biofilm. Plastic and Reconstructive Surgery.
5. Schierle CF, Behm CG, OShaughnessy K, Ding XZ, Galiano RD, Mustoe TA. Rapid and simple epidermal keratinocyte RNA extraction technique allowing temporally and spatially specific gene transcript characterization in the mouse and rabbit. Biotechniques.
6. Fine N, Schierle C. Master Techniques in Rhinoplasty. Aesthetic Surgery Journal. 2012 ; 32: 1037-1038.
7. Schierle CF, Casas LA. Non-surgical rejuvenation of the aging face using injectable poly- L-lactic acid (Sculptra Aesthetic) for restoration of soft tissue volume. Aesthetic Surgery Journal. 2011; 31(1): 95-109. doi: 10.1177/1090820X10391213
8. Kim JY, Buck DW, Forte AJ, et al. Risk factors for compartment syndrome in traumatic brachial artery injuries: an institutional experience in 139 patients. Journal of Trauma. 2009; 67(6): 1339-1344. doi: 10.1097/TA.0b013e318197b999
9. Schierle CF, Krol J. Can new hemostatic dressings facilitate sharp debridement with high-risk patients? Podiatry Today. 2009; 22(7): 20-22.
10. Schierle CF, Rawlani V, Galiano RD, Kim JY, Dumanian GA. Improving outcomes of the distally based hemisoleus flap: Principles of angiosomes in flap design. Plastic and Reconstructive Surgery. 2009; 123(6): 1748-1754. doi: 10.1097/PRS.0b013e3181a65a74
11. Schierle CF, De la Garza M, Mustoe TA, Galiano RD. Staphylococcal biofilms impair wound healing by delaying reepithelialization in a murine cutaneous wound model. Wound Repair and Regeneration. 2009; 17(3): 354-359. doi: 10.1111/j.1524-475X.2009.00489.x
12. Kim JY, Schierle CF, Subramanian V, et al. A prognostic model for the risk of development of upper extremity compartment syndrome in the setting of brachial artery injury. Annals of Plastic Surgery. 2009; 62(1): 22-27. doi: 10.1097/SAP.0b013e3181776327
13. Kloeters O, Schierle C, Tandara A, Mustoe TA. The use of a semi-occlusive dressing reduces epidermal inflammatory cytokine expression and mitigates dermal proliferation and inflammation in a rat incisional model. Wound Repair & Regeneration. 2008; 16(4): 568-575. doi: 10.1111/j.1524-475X.2008.00404.x
14. Mustoe TA, Kim P, Schierle CF. Outpatient abdominoplasty under conscious sedation. Aesthetic Surgery Journal. 2007; 27(4): 442-449. doi: 10.1016/j.asj.2007.05.003
15. Schierle C, Winograd JM. Radiation-induced brachial plexopathy: Complication without a cure. Journal of Reconstructive Microsurgery. 2004; 20(2): 149-152. doi: 10.1055/s-2004-820771
16. Schierle CF, Berkmen M, Huber D, Kumamoto C, Boyd D, Beckwith J. The DsbA signal sequence directs efficient, cotranslational export of passenger proteins to the Escherichia coli periplasm via the signal recognition particle pathway. Journal of Bacteriology. 2003; 185(19): 5706-5713. doi: 10.1128/JB.185.19.5706-5713.2003
17. Boyd D, Schierle C, Beckwith J. How many membrane proteins are there? Protein Science. 1998; 7(1): 201-205. doi: 10.1002/pro.5560070121
18. Prinz WA, Spiess C, Ehrmann M, Schierle C, Beckwith J. Targeting of signal sequenceless proteins for export in Escherichia coli with altered protein translocase. EMBO Journal. 1996; 15(19): 5209-5217.
19. Kim CW, Markiewicz P, Lee JJ, Schierle CF, Miller JH. Studies of the hyperthermophile Thermotoga maritima by random sequencing of cDNA and genomic libraries. Identification and sequencing of the trpEG (D) operon. Journal of Molecular Biology. 1993; 231(4): 960-981. doi: 10.1006/jmbi.1993.1345
Professor and Chief
Acute Care Surgery Division
Department of Surgery
University of Iowa Hospitals and clinics
Iowa City, Iowa, USA
Dr. Kent became a trauma/critical care attending at the University of Iowa following his fellowship in Surgical Critical Care at Washington University 2001. He currently serves as the Surgical Director in the SICU at the University of Iowa since 2005. He established and currently directs an ACGME-accredited Surgical Critical Care Fellowship as well as the Director in the Division of Acute Care Surgery at the University of Iowa Hospitals.
His research interests include epidemiology study in traumatic injury prevention, trauma system set-up, morbid obesity and trauma care outcome, surgical infection control and immunology and inflammatory response in obesity.
National or Regional Conference Presentation and Visiting Professorship
1.Blunt Abdominal Trauma Grant round speaker at Mary Greenley Medical Center at Ames, Iowa. March 7th 2007
2.The RESUS (Restore Effective Survival in Shock) Trial Department of Surgery Postgraduate Conference (in association with American College of Surgeons, Iowa Chapter). Nov. 10th, 2005
3.Radio interview with Roy Justis of KXIC radio station during the National Hernia Awareness Month, in June 2005 to help promote public awareness of hernia problem.
4. Options in Management of Torso Penetrating Injury Trauma Care Update Conference by Covenant Health System at Hawkeye Community College, Waterloo, Iowa. Dec. 3rd, 2005.
5. Minimally Invasive Techniques for Hemostasis Endovascular Intervention. Surgical Update for Nurses, 2002. Highlander Inn, Iowa City, Iowa. March 27th, 2002.
Grant Rounds and Local Conference Presentations
1.Trauma Conference Presentation, West Virginia University, Health Science Center, Morgantown, Morgantown, West Virginia, Airway Management in Trauma, Nov. 20, 1996.
2.Trauma Conference Presentation, West Virginia University, Health Science Center, Morgantown, Morgantown, West Virginia, Shock Management in Pediatric Trauma, Feb. 12, 1997.
3.Trauma Conference Presentation, West Virginia University, Health Science Center, Morgantown, Morgantown, West Virginia, Chest Wall Trauma: Flail Chest, July 23, 1997.
4. Grand Rounds, Department of Surgery, West Virginia University, Health Science Center, Morgantown, Morgantown, West Virginia, Update in Trauma Surgery, March 22, 1999.
5.Grand Rounds, Department of Surgery, University of Iowa, Iowa City, Iowa. Prophylactic Inferior Vena Cava Interruption in Severe Trauma. March 11th, 2002.
6.Grand Rounds, Department of Surgery, University of Iowa, Iowa City, Iowa. Impact of Morbid Obesity on Trauma Care Outcome. Feb 17th, 2009
7.Workers Comp Conference, Hernia Talk. Cedar Rapids, Iowa October 25, 2013.
Honors and Awards
In-Service Scholarship Award, 1998
Outstanding Resident Teaching Award, 1999
Above and Beyond (UIHC), 2005
1. Choi K, Sherry RM, Wei JP. Traumatic pseudoaneurysm of the supra-orbital artery associated with von-Willebrand Factor Deficiency. Journal of Trauma. 1993; 3(6): 966-967.
2. Choi K, Peek-Asa C, Lovell M, Zwerling C, Torner JC, Kealey GP. Complications following therapeutic trauma laparotomy . Journal of the American College of Surgeons. 2005; 201(4): 546-553. doi: http://dx.doi.org/10.1016/j.jamcollsurg.2005.05.012
3. Royer N, O Brien A, Choi K. Potential etiology of increased mortality among obese trauma patients. Journal of Surgical Research. 2007; 137(2): 284-285. doi: http://dx.doi.org/10.1016/j.jss.2006.12.352
4. Liao J, Choi KC. Cost Expansion vs. Cost Control-Lessons from the Canadian System. The New England Journal of Medicine. 2009; 361(21): e107. doi: 10.1056/NEJMopv0909476
5. Hallam DM, Liao J, Choi KC. Manure Pit Injuries: Deadly and Preventable. Journal of Emergencies, Trauma and Shock. 2012; 5(3): 253-256. doi: 10.4103/0974-2700.99702
6. Sun R, Skeete D, Wetjen K, et al. A pediatric cervical spine clearance protocol to reduce radiation exposure in children. Journal of Surgical research. 2013. doi: 10.1016/j.jss.2012.12.048
7. Philip AF, Fangman W, Liao J, Lilienthal M, Choi K. Helmets Prevent Motorcycle Injuries. Traffic Injury Prevention. 2013; 14: 496-500. doi:
8. Sun R, Choi K, Coots B. The use of the Mitek anchoring system on the iliac crest for flank incisional hernia repair. European Journal of Plastic Surgery. 2013; 36(5). doi: 10.1007/s00238-012-0793-0
9. Mohr NM, Harland KK, Skeete D, Pearson K, Choi K. Duration of prehospital intubation is not a risk factor for development of early ventilator-associated pneumonia. J Crit Care. 2014; 29(4): 539-544. doi: 10.1016/j.jcrc.2014.03.030
10. Choi K . Spine entitled Entero-paraspinous fistula from recurrent spinal metastatic renal cell carcinoma - [SPINE14-294R1]. Journal of Neurosurgery. 2014.
Assistant Professor of Surgery (MEST)
Division of Cardiothoracic Surgery
Department of Surgery
Emory University School of Medicine
201 Dowman Drive, Atlanta
Georgia 30322, USA
Prior to coming to the United States, Dr. Al Salihi was an attending cardiac surgeon at Ibn Al Bittar Cardiac Surgery in Baghdad; held several positions at the Iraqi Center for Heart Diseases, including general director; and worked as a cardiac surgeon at Al-Issra General Hospital in Amman, Jordan. Upon arriving in the states in 2008, he studied for the three steps of the United States Medical Licensing Examination (USMLE) and recertified his credentials at Kaplan Institute, Akron, Ohio. He then joined the Cleveland Clinic as a clinical associate staff surgeon while completing fellowships in cardiac surgery and heart and lung transplantation. He joins Emory as its first surgeon dedicated primarily to heart and lung procurement for transplantation. His clinical interests also include minimally invasive valve surgery and VATS thoracic surgery, and his research focus is ex vivo lung perfusion.
Adult cardiac surgery; Procurement of heart and lungs for transplantation; Heart and lung transplantation, Robotically assisted mitral valve surgery, Minimally invasive valve surgery, VATS thoracic surgery
Ex vivo lung perfusion
AFFLIATIONS AND SOCIETIES
Member of the Society of Thoracic Surgeons (STS)
Member of the International Society for Heart and Lung Transplantation (ISHLT)
Member of the American Medical Association (AMA)
Member of the Jordanian Medical Associations.
Member of the Iraqis Surgeons Society
Member of the Higher Consultation Commission of Iraqi Cardiac Surgery
Member of Iraqi Society of Cardio- Thoracic and Vascular
Physicians and surgeons (Treasurer)
Member of the Iraqi Medical Association
Journals and Publications
1. Hussain ST, Alsalihi M, Blackstone EH, Pettersson GB. Maximized left atrial dome approach for left atrial tumor resection. The JTCVS. 2014.
2. Svensson LG, Blackstone EH, Alsalihi M, et al. Mid-term results of David reimplantation in patients with connective tissue disorder. Annal of thoracic surgery. 2013; 95(2): 555-562. doi: 10.1016/j.athoracsur.2012.08.043.
Consultant Surgical Oncology/ Head & Neck surgeon
Chief of Hepatobiliary services
Tawam Cancer Center
Alain Affiliated with John Hopkins
Abu Dhabi, UAE
Dr. Sadir Alrawi was appointed as interim chair of department of surgery at Tawam Hospital in October 2013 to take full responsibilities for the surgical department with nine surgical divisions in ACGME accredited surgical residency program and supporting fellowships programs.
Tawam Hospital is affiliated with JOHN HOPKINS and is only tertiary referral cancer center for all UAE, hosting highly specialized 42 surgical consultants and specialists in different subspecialties including Surgical oncology, Breast oncology, Orthopedics, Vascular surgery, Thoracic oncology, ENT, Head & Neck surgery, Pediatric surgery, Plastic surgery, Bariatric surgery, Ophthalmology in addition to General surgery and trauma.
Dr Alrawi major interest is Gastrointestinal Oncology, including Esophageal, Gastric, Pancreas, Liver and colonic surgery with special interest in endocrine surgery including thyroid, parathyroid and adrenal surgery.
Dr. Sadir Alrawi, was the Chief of the Surgical Oncology Program at Comprehensive Cancer Center of 21st Century in Jacksonville, Florida from 2008- 2013.
Prior to that, Dr. Alrawi was an assistant professor in the Department of Surgery/Division of Surgical Oncology at University of Florida, Jacksonville. Dr Alrawi trained in various Academic institutes in Surgical Oncology all over including Roswell Park, Cancer institute, Buffalo, Royal Free Hospital, UC of London and Ninewells Hospital, U of Dundee.
Dr. Alrawi, who is American board certified, completed his Head & Neck fellowship and Surgical Oncology fellowship at Roswell Park Cancer institute (NCI) designated in 2006. Dr Alrawi did advanced Laparoscopic oncology training with Professor Alfred Cuschieri in Dundee 1992-1993, advanced colorectal oncology training with E Lloyd Davis in Cornwall, England 1993-1995 and advanced surgical oncology with Professor Marc Winslett, London 1995-1996.
He has received many academic and scholarly honors while in training and during his clinical practice years, and are an often-invited speaker at both public and professional meetings dedicate to helping education with cancer management.
Dr. Alrawi has been involved in numerous research activities throughout his career in an effort to improve our understanding of cancer early diagnosis and multidispilinary approach.
In his 28 year experience of Surgical Oncology, Dr. Alrawi was able to publish more than 40 papers in per reviewed journals and more than 150 presentations in local, national and international meetings both in clinical and basic sciences.
Dr. Alrawi is passionate about community outreach, and fervently believes that cancer care and health awareness, coupled with excellence in cancer diagnosis and treatment handled in multidisplinary approach by specialized team, can and will continue to save lives.
His research interests include: Surgical oncology including basic science
MEDICAL & SCIENTIFIC SOCIETIES
• Association of Academic Surgery (AAS), Active member
• Society of Surgical Oncology,
• American College of Surgeons,
• American Medical Association
• British General Medical Council
• Royal College of Surgeons of England
• Royal College of Surgeons of Edinburgh
• Iraqi Medical Association
AWARDS & HONORS
• The Second and the 3rd Poster Awards in Research day at University of Florida, May, 2007
• The GI ASCO Foundation Merit award 2006
• Third Place winner in the 2005 WNY American College of Surgeons Essay Contest, Buffalo, New York
• Genetics in Oncology Workshop: Cancer Education Consortium, March, 2004
• Third Place winner in the 2004 WNY American College of Surgeons Essay Contest, Buffalo, New York.
• Minimally Invasive Cardiac Surgery meeting, best moderated poster, Atlanta, Georgia, June 2000
• Brooklyn Surgical Society, Best Basic Scientific paper Presentation, May 2000
• Lutheran Medical Center Best Project in Clinical Sciences, May 1999, June2000
• Iraqi Graduate Fellowship (Medical School Scholarship) 1985
• Baghdad University Scholarship (Undergraduate), 1979
1. Alrawi SJ, Samee M, Raju R, Shirazian D, Acinapaura A, Cunningham J. Adhesion Molecules (ICAM-1 & VCAM-1) Levels: A Comparative Study of Endoscopic and Open Method of Vein Harvesting for Coronary Artery Bypass Surgery. Heart Surgery Forums Journal. 2000; 3(3): 241-245.
2. Alrawi SJ, Raju R, Acinapura AJ, Cunningham, JN. Saphenous Vein Endothelial Cell Viability: A Comparative Study of Endoscopic And Open Incision Saphenectomy For Coronary Artery Bypass Grafting. Journal of Society of Laproendoscopic Surgery. 2001; 5: 37-45.
3. Oreadu CO MD, Alrawi SJ, Reddy R, Raju R. Heart Failure Mimics Inflammatory Breast Carcinoma (Case Report). Journal of Breast. 2001; 7(2): 117-119.
4. Alrawi SJ. Endoscopic Saphenous Vein Harvest for Coronary Artery Bypass Surgery Dose not Increase Endothelial Cell Expression of Tumor Necrosis Factor. Annals of Royal College of Physicians and Surgeons of Canada. 2001; 34(1): 12-16.
5. Alrawi SJ, Raju R, Satheesan R, Acinapura A, Cunningham JN. Interleukin 1, Interleukin 2, and Interleukin 10 Expression as an Indicator of Adhesion Molecules Synthesis in Coronary Artery Bypass Surgery. Heart Surgery Forums. 2001; 1(4): 47-52.
6. Alrawi SJ, Balaya F, Raju R, Acinapura A, Cunningham JN. A Comparative Study of Endothelial Cell Injury During Open and Endoscopic Saphenectomy: An Electron Microscopic Evaluation. Heart Surgery Forum. 2001; 4(2): 120-127.
7. Alrawi SJ, Abo deeb A, Samee M, et al. Significance of Interferon In Coronary Artery Bypass Surgery. Journal of Society of Laproendoscopic Surgery. 2001; 5(3): 249-253.
8. Sandoval S, Alrawi SJ, Samee M, Raju R, Acinapura A, Cunningham JN. Cytokine Analysis of Salvaged Blood By Cell Saver In Trauma And Coronary Artery Bypass Patients. Heart Surgery Forum. 2001; 4(2): 113-119.
9. Alrawi SJ, Raju R, Samee M, Balaya F, Acinapura A, Cunningham JN. Nitric Oxide Suppression by Interleukin-10 (IL-10) in Endoscopic and Open Method of Vein Harvesting for Coronary Artery Bypass Surgery. Journal of Society of Laproendoscopic Surgery. 2002; 6(1): 5-9.
10. Alrawi SJ, Houshan I, Raju R, Cunningham JN , Acinapura AJ. Glove Reinforcement An Alternative To Double Gloving. Infection Control and hospital Epidemiology. 2001; 22(8): 526-527. doi: 10.1086/501947
11. Alrawi SJ, Raju R, Cane J, Acinapaura AJ . Thoracoscopic Pleural Biopsy, Pleural Drainage And Under Local Anesthesia: A New Technique In Surgical Practice. Journal of Society of Laproendoscopic Surgery. 2002; 6(2): 143-147.
12. Alrawi SJ, Houshan I, Raju R, Cunningham JN, Acinapura AJ. Cardiac Surgical Procedures and Glove Reinforcement. Heart Surgery Forums. 2002; 5(1): 66-68.
13. Alrawi SJ, Raju R, Cunningham JN, Acinapura AJ. Would The Blood Volume Analyzer -100 (BVA -100) Be An Alternative To Pulmonary Artery Catheter (PAC) In Critically Ill Patients. Saudi Med J. 2002; 23(11): 1367-1372.
14. Tan D, Wiseman S, Zhou Y, et al. Definition of a region of loss of heterozygosity at chromosome 11q23.3-25 in head and neck squamous cell carcinoma using laser capture microdissection technique. Diagnostic Molecular Pathology. 2004; 13(1): 33-40.
15. Alrawi SJ, Deeb G, Loree T, et al. Lipomatus Hemangiopericytoma of H&N; Immunohistochemical and DNA Ploidy analyses. Head Neck. 2004; 26(6): 544-549. doi: 10.1002/hed.20054
16. Said M, Wiseman S, Yang J, et al. Tissue Eosinophilia: A morphologic marker for assessing stromal invasion in laryngeal squamous neoplasms. BMC Clin Pathol. 2005; 5(1): 1. doi: 10.1186/1472-6890-5-1
17. Douglas W, Rigual N, Giese W, et al. Advanced soft palate cancer: The clinical importance of the parapharyngeal space. Otolaryngology- Head and Neck Surgery. 2005; 133(1): 66-69. doi: 10.1016/j.otohns.2005.03.007
18. Alrawi SJ, Tan D, Douglas W, et al. Tissue Eosinophilia: A Valuable Morphologic Marker In Assessing Stromal Invasion, Locoregional Recurrence & Survival In Head & Neck Squamous Neoplastic Lesions. The Cancer Journal. 2005; 11(3): 217-225.
19. Rigual NR, Anderson GR, Loree TR, Wiseman S, Alrawi SJ, Stoler DL. Molecular Prognosticators and Genomic Instability in Papillary Thyroid Cancer. Laryngoscope. 2005; 115: 1479-1485. doi: 10.1097/01.mlg.0000172045.38907.52
20. Alrawi SJ, Sullivan M, Winston J, et al. Primitive Neuroectodermal Tumor of the Mandible: Cytogenetic & Molecular Biology Aberration. Journal of Oral and Maxillofacial Surgery. 2005; 63: 1216-1221. doi: http://dx.doi.org/10.1016/j.joms.2005.04.014
21. Alrawi SJ, Tan D, Loree T, Hicks W, Rigual N, Lorè Jr J. Primary Adenocarcinoma of Cervical Esophagus (Case report and review of the literature). Journal of Clinical and Experimental Cancer Research. 2005; 24(2): 207-211.
22. Alrawi SJ, Stoler D, Tan D, et al. Genomic Instability, DNA Alterations and Tumor Eosinophilic Expression in Head and Neck Squamous Cell Carcinoma. Cancer Genomics & Proteomics. 2005; 2: 307-316.
23. Khoury T, Tan D, Wang J, et al. Inclusion of MUC1 (Ma695) in a panel of immunohistochemical markers is useful for distinguishing between endocervical and endometrial mucinous adenocarcinoma. BMC Clin Pathol. 2006; 6(1): 1. doi: 10.1186/1472-6890-6-1
24. Alrawi SJ, Schiff M, Carroll RE, et al. Aberrant Crypt Foci. Anticancer Research. 2006; 26(1A): 107-119.
25. Alrawi SJ, Carroll R, Hill H, et al. Genomic instability of human aberrant crypt foci measured by inter-(simple sequence repeat) PCR and array-CGH. Mutat Res. 2006; 26. doi: 10.1016/j.mrfmmm.2006.05.022
26. Swede H, Bartos JD, Chen N, et al. Genomic profiles of colorectal cancers differ based on patient smoking status. Cancer Genet Cytogenet. 2006; 168(2): 98-104. doi: http://dx.doi.org/10.1016/j.cancergencyto.2006.02.009
27. Yang J, Ramnath N, Moysich KB, et al. Prognostic significance of MCM2, Ki-67 and gelsolin in non-small cell lung cancer. BMC Cancer. 2006; 6: 203. doi: 10.1186/1471-2407-6-203
28. Esquivel J, Sticca R, Sugarbaker P, et al. Society of Surgical Oncology Annual Meeting. Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in the management of peritoneal surface malignancies of colonic origin: a consensus statement. Society of Surgical Oncology. Ann Surg Oncol. 2007; 14(1): 128-133.
29. Liang JJ, Alrawi SJ, Tan D. Nomenclature, Molecular Genetics and clinical Significance of the Precursor Lesions in Serrated Polyp Pathway of the Colorectum. Int J Clin Exp Pathology. 2008; 1: 317-324.
30. Yang J, Li Y, Khoury T, Alrawi SJ, Goodrich DW, Tan D. Relationships of hHpr1/p84/Thoc1 Expression to Clinicopathologic Characteristics and Prognosis in Non-small Cell Lung Cancer. Annals of Clinical & Laboratory Science. 2008; 38: 2.
31. Truong CD, Li W, Feng W, et al. Alpha-Methylacyl-CoA Racemase Expression is Upregulated in Gastric Adenocarcinoma: A Study of 249 Cases. Int J Clin Exp Pathol. 2008; 1: 518-523.
32. Liang JJ, Alrawi SJ, Fuller GN, Tan D. Carcinoid tumors arising in tailgut cyst may be associated with estrogen receptor status: case report and review of literature. Int J Clin Exp Pathol. 2008; 1(6): 539-543.
33. Ahmed BH, Ahmed A, Tan D, et al. Post-laparoscopic cholecystectomy pain: effects of intraperitoneal local anesthetics on pain control--a randomized prospective double-blinded placebo-controlled trial. Am Surg. 2008; 74(3): 201-209.
34. Yang J, Li Y, Khoury T, Alrawi SJ, Goodrich DW, Tan D. Relationships of hHpr1/p84/Thoc1 expression to clinicopathologic characteristics and prognosis in non-small cell lung cancer. Ann Clin Lab Sci. Spring. 2008; 38(2): 105-112.
35. Orlando FA, Tan D, Baltodano JD, et al. Aberrant crypt foci as precursors in colorectal cancer progression. J Surg Oncol. 2008; 98(3): 207-213. doi: 10.1002/jso.21106
36. Feng W, Brown RE, Trung CD, et al. Morphoproteomic profile of mTOR, Ras/Raf kinase/ERK, and NF-kappaB pathways in human gastric adenocarcinoma. Ann Clin Lab Sci. 2008; 38(3): 195-2009.
37. Truong CD, Feng W, Li W, et al. Characteristics of Epstein-Barr virus-associated gastric cancer: a study of 235 cases at a comprehensive cancer center in U.S.A. J Exp Clin Cancer Res. 2009; 28: 14. doi: 10.1186/1756-9966-28-14
38. Khoury T, Alrawi S, Ramnath N, et al. Eukaryotic initiation factor-4E and cyclin D1 expression associated with patient survival in lung cancer. Clin Lung Cancer. 2009; 10(1): 58-66. doi: 10.3816/CLC.2009.n.009
39. Khoury T, Arshad A, Bogner P, et al. Apoptosis-related (survivin, Bcl-2), tumor suppressor gene (p53), proliferation (Ki-67), and non-receptor tyrosine kinase (Src) markers expression and correlation with clinicopathologic variables in 60 thymic neoplasms. Chest. 2009; 136(1): 220-228. doi: 10.1378/chest.08-2482
40. Hassid VJ, Orlando FA, Awad ZT, et al. Genetic and molecular abnormalities in cholangiocarcinogenesis. Anticancer Res. 2009; 29(4): 1151-1156.
41. Al-Agha OM, Liu W, Chandrasekhar R, et al. CD138 (Syndecan-1) in thymic tumors: correlation with various World Health Organization types and clinical outcome. Int J Clin Exp Pathol. 2010; 3(3): 280-287.
Director and Assistant Professor
Structural Heart Research & Innovation Lab
Division of Cardiothoracic Surgery
380B, Northyards Blvd
Atlanta, GA 30313, USA
• (2014-Present) Program Faculty, Biomedical Engineering,
Wallace H. Coulter Department of Biomedical Engineering,
Georgia Institute of Technology
• (2010-Present) Assistant Professor, Division of Cardiothoracic Surgery, Director, Structural Heart Disease Research & Innovation Lab, Emory University School of Medicine
• (2003-2004) Intern, Hypersonic Propulsion Division, Indian Defense Research and Development Organization, Hyderabad, India
• (2012-2012) Postdoctoral research fellowship [Funded by a competitive career development award from Leducq Fondation in Paris], Heart Science Center, Imperial College London, UK
• (2010) Ph.D. in Bioengineering [Funded by a fellowship from the American Heart Assoc], Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, USA
• (2006-2008) M.S. in Mechanical Engineering, Woodruff Department of Mechanical Engineering, Georgia Institute of Technology, Atlanta, USA
Major: Mechanics Minor: Biomaterials
• (2000-2004) B.E in Mechanical Engineering, Osmania University, Hyderabad, India, GPA: 4.0/4.0, Highest honors
Thesis: Computational modeling of nonpremixed combustion in supersonic rocket engines
His research interests include:
Structural heart and valve disease, involving lesions that impact the structure, function and biology of the heart valves, and the myocardium are the focus of my research. His interest is in understanding the mechanisms underlying the initiation and progression of disease in these structures, their biological remodeling from initiation of the structural lesion to complete failure, and in developing therapies specific to these lesions to control their progression. Their ultimate goal is to improve our knowledge of disease initiation and propagation, and innovate new therapeutic strategies and devices to treat patients.
(i) Functional mitral regurgitation Mitral regurgitation developing in patients after a heart attack, impairs cardiac function and increases cardiac morbidity and mortality. His laboratory was investigating the pathogenic mechanisms of functional mitral regurgitation, and developing novel surgical and transcatheter devices to address this challenging valvular lesion.
(ii) Mitral valve prolapse Mitral valve prolapse occurs among 23% of all adult Americans, which when left untreated causes increased risk of sudden cardiac death. His laboratory was investigating the pathogenic mechanisms underlying mitral valve prolapse, and the biomechanical parameters that cause progressive valve deterioration in this disease state.
(iii) Timing of mitral valve repair and its impact on left ventricular remodeling Optimal timing of mitral valve repair, whether functional mitral regurgitation and due to mitral valve prolapse, is necessary to rescue the ventricle from failing. His laboratory is investigating the time course of left ventricular remodeling in mitral valve disease, and for markers to identify the optimal timing of mitral valve repair to achieve best rescue of the ventricle.
(iv) TypeB aortic dissection TypeB aortic dissection is a structural tear of the aorta that develops at regions of atherosclerotic plaque, and propogates through the entire distal aorta, and is associated with up to 25% in hospital mortality. His laboratory was investigating the impact of typeB aortic dissection on the aortic hemodynamics, and the impact of endovascular aortic repair on hemodynamics.
HONORS AND AWARDS
• (2014) American Heart Association Scientist Development Grant
• (2014) Final 10, Med Tech Idol Competition, IN3 Dublin
• (2012) Emory University Innovation of the Year Award
• (2011) Leducq Fondation Career Development Award
• (2011) 1st place, SEBIO Business Plan Competition, Duke University
• (2009) 1st place, Ventura Business Plan Competition, India
• (2009) Social Relevance Award, Ventura Business Plan Competition
• (2009) Gandy Diaz Teaching Fellowship
• (2008) American Heart Association Pre Doctoral Fellowship Grant
• (2004) Highest honors in the graduating class
1. Kalra K, Wang Q, McIver BM, et al. Temporal changes in interpapillary muscle dynamics as an active indicator of mitral valve and left ventricular interaction in ischemic mitral regurgitation in humans. Journal of the American College of Cardiology. 2014; 64(18): 1867-1879. doi: 10.1016/j.jacc.2014.07.988
2. Miragoli M, Yacoub MH, ElHamamsy I, et al. Side specific mechanical properties of valve endothelial cells. American Journal of Physiology Heart and Circulatory Physiology. 2014; 307(1): H1524. doi: 10.1152/ajpheart.00228.2013
3. Padala M, Sweet M, Hooson S, Thourani VH, Yoganathan AP. Hemodynamic Comparison of Mitral Valve Repair: techniques for a flail anterior leaflet. Journal of Heart Valve Disease. 2014; 23(2): 171-176.
4. Padala M, Gyoneva LI, Thourani VH, Yoganathan AP. Impact of mitral valve geometry on hemodynamic efficacy of surgical repair in secondary mitral regurgitation. Journal of Heart Valve Disease. 2014; 23(1): 79-87. doi:
5. Lam A, ClementGuinaudeau S, Padala M, Eisner R, Thourani VH, Oshinski JO. Post Surgical Hemodynamics of Aortic Valve Bypass Operation Evaluated with Phase Contrast Magnetic Resonance Imaging. Journal of Magnetic Resonance in Medicine. 2014; 40(4): 899-905. doi: 10.1002/jmri.24423.
6. Thourani VH, Gunter RL, Hurst S, et al. Postoperative Warfarin Following Mitral Valve Repair or Bioprosthetic Valve Replacement. Journal of Heart Valve Disease. 2013; 22(5): 716-723. doi:
7. Padala M, Cardinau B, Gyoneva LI, Thourani VH, Yoganathan AP. Comparison of artificial neochordae and native chordal transfer in the repair of a flail posterior mitral leaflet: an experimental study. Annals of Thoracic Surgery. 2013; 95(2):629-633. doi: 10.1016/j.athoracsur.2012.09.055
8. Yamauchi H, Vasilyev NV, Marx GR, et al. Right Ventricular Papillary Muscle Approximation as a Novel Technique of Valve Repair for Functional Tricuspid Regurgitation in an Ex Vivo Porcine Model. Journal of Thoracic and Cardiovascular Surgery. 2012; 144(1):235-242. doi: 10.1016/j.jtcvs.2012.01.028
9. Padala M, Jimenez JH, Yoganathan AP, Chin A, Thourani VH. Transapical Beating Heart Cardioscopy Technique for OffPump Visualization of Heart Valves. Journal of Thoracic and Cardiovascular Surgery. 2012; 144(1): 2314. doi: 10.1016/j.jtcvs.2011.11.038
10. Balachandran K, Hussain S, Yap CH, Padala M, Chester AH, Yoganathan AP. Elevated Cyclic Stretch and Serotonin Result in Degenerative Aortic Valve Remodeling via a Mechanosensitive 5HT2A Receptor Dependent Pathway. Cardiovascular Pathology. 2012; 21(3): 206-213 doi: 10.1016/j.carpath.2011.07.005
11. Padala M, Gyoneva LI, Yoganathan AP. Effect of anterior strut chordal transection on the force distribution on the marginal chordae of the mitral valve. Journal of Thoracic and Cardiovascular Surgery. 2012; 144(3): 624-633. doi: 10.1016/j.jtcvs.2011.10.032
12. Weiler M, Yap CH, Balachandran K, Padala M, Yoganathan AP. Regional analysis of dynamic deformation characteristics of native aortic valve leaflets. Journal of Biomechanics. 2011; 44(8): 145965 doi: 10.1016/j.jbiomech.2011.03.017
13. Padala M, Thourani VH, Keeling BW. Innovations in Heart Valve Therapies, Invited review article. Circulation Journal, Journal of the Japanese Circulation Society, Circulation Journal. 2011; 75(5): 102841 doi:
14. Delmo Walter EM, Vasilyev NV, Sill B, et al. Creation of a tricuspid valve regurgitation model from tricuspid annular dilatation using the cardioport video assisted imaging system. Journal of Heart Valve Disease. 2011; 20: 184-188 doi:
15. Padala M, Sarin EL, Babaliaros V, Block P, Thourani VH. Engineering Review of Transcatheter Aortic Valve Technologies. Cardiovascular Engineering and Technology. 2010; 1(1): 77-87. doi: 10.1007/s13239-010-0008-4
16. Padala M, He Z, Sacks MS, Liou SW, Jimenez JH, Yoganathan AP. Mechanics of the mitral valve strut chordae insertion region. Journal of Biomechanical Engineering. 2010; 132(8): 081004. doi: 10.1115/1.4001682
17. Padala M, Hutchison R, Croft LR, et al. Saddle shape of the mitral annulus reduces systolic strains on the P2 segment of the posterior mitral leaflet. Annals of Thoracic Surgery. 2009; 88(5):1499-1504. doi: 10.1016/j.athoracsur.2009.06.042
18. Padala M, Powell SN, Croft LR, Thourani VH, Yoganathan AP, Adams DH. Mitral Valve Hemodynamics after repair of acute posterior leaflet prolapse: quadrangular resection versus triangular resection versus neochordoplasty. Journal of Thoracic and Cardiovascular Surgery. 2009 ; 138(2): 309-315. doi: 10.1016/j.jtcvs.2009.01.031
19. Erek E, Padala M, Pekkan K, et al. Mitral Web - A New Concept for Mitral Valve Repair: improved engineering desigh and invitro studies. Journal of Heart Valve Disease. 2009; 18(3): 3006. doi:
20. Padala M, Vasilyev N, Owen Jr JW, et al. Cleft Closure and Undersizing Annuloplasty Improve Mitral Repair in Atrioventricular Canal Defects. Journal of Thoracic and Cardiovascular Surgery. 2008; 136(5): 124-139. doi: 10.1016/j.jtcvs.2008.05.043
21. Sucosky P, Padala M, Elhamalli A, Balachandran K, Jo H, Yoganathan AP. Design of an Exvivo Culture System to Investigate the Effects of Shear Stress on Cardiovascular Tissue. Journal of Biomechanical Engineering. 2008; 130(3): 035001. doi: 10.1115/1.2907753.
22. Jimenez JH, Liou SW, Padala M, et al. A saddle shaped annulus reduces strains in the central region of the anterior mitral valve leaflet. Journal of Thoracic and Cardiovascular Surgery. 2007; 134(6): 15628. doi: http://dx.doi.org/10.1016/j.jtcvs.2007.08.037
Assistant Professor of Surgery
Emory University School of Medicine
Director, Vascular and Endovascular Surgery
Grady Memorial Hospital
69 Jesse Hill Jr Dr #304
Atlanta, GA 30303, USA
After joining Emory in 2011 as Director of Vascular and Endovascular Surgery at Grady Memorial Hospital, Dr. Rajani expanded the endovascular capability of the hospital to treat vascular disease and vascular trauma. He attended medical school at the University of Michigan, did his General Surgery training at the Cleveland Clinic, his surgical critical care residency and trauma fellowship at Emory, and completed his vascular and endovascular surgery fellowship at Cleveland Clinic. He has since served on multiple local and national committees and published several important peer-reviewed articles.
His research interests include: vascular surgery and endovascular surgery.
Oral Examiner for Vascular Surgery
Southern Association for Vascular Surgery
Invited Chapter Writer, Aortic and Iliac Arterial Disease
Vascular Education Self-Assessment Program (VESAP)
Endovascular Skills for Trauma and Resuscitative Surgery (ESTARS)
Executive Committee Board of Directors
Committee Chair, Endovascular Training
Peripheral Vascular Surgery Society
Program Committee for 2012 Annual Meeting
Eastern Association for the Surgery of Trauma
Co-Chair, Lower Extremity Penetrating Trauma Practice Management Group
Prospective Observational Vascular Injury Trial (PROOVIT)
Site Principal Investigator, AAST-sponsored multicenter trial
Vascular and Endovascular Surgery Society
Program Committee for 2013 Annual Meeting
Vascular and Endovascular Surgery Society
American Medical Association
American College of Surgeons
Association for Academic Surgery
National Ultrasound Faculty, American College of Surgeons
Eastern Association for the Surgery of Trauma
Society of Vascular Surgery
Peripheral Vascular Surgery Society
Southern Association for Vascular Surgery
Georgia Vascular Society, Charter Member
Society of Critical Care Medicine
Society of American Gastrointestinal Endoscopic Surgeons
American Association of Physicians from India
South Asian American Vascular Surgery Society
Published and accepted research articles
1. Rajani RR, Claridge JA, Yowler CJ, et al. Improved outcome of adult blunt splenic trauma: a cohort analysis. Surgery. 2006; 140(4): 625-631. doi: http://dx.doi.org/10.1016/j.surg.2006.07.005
2. Ball CG, Karmali S, Rajani RR. Laparoscopy in trauma: an evolution in progress. Injury. 2009; 40(1): 7-10. doi: http://dx.doi.org/10.1016/j.injury.2008.09.005
3. Ball CG, Rajani RR, Feliciano DV, Nicholas JM. Venous air emboli and computed axial tomography power contrast injectors. Am J Surg. 2009; 197: 57-58. doi: http://dx.doi.org/10.1016/j.amjsurg.2008.08.010
4. Rajani RR, Ball CG, Feliciano DV, Vercruysse GA. Vasopressin in hemorrhagic shock. Am Surg. 2009; 75: 1207-1212.
5. Ball CG, Trexler S, Rajani RR, Vercruysse GA, Feliciano DV, Nicholas JM. Importance of liver drainage in biliary-bronchopleural fistula resulting from thoracoabdominal gunshot injury. Can J Surg. 2009; 52: 12-13.
6. Ball CG, Jafri SM, Kirkpatrick AQ, et al. Traumatic urethral injuries: does the digital rectal examination really help us? Injury. 2009; 40: 984-986. doi: 10.1016/j.injury.2009.03.003
7. Rajani RR, Dente CJ, Ball CG, Feliciano DV. Collapse of a thoracic aortic sent graft after cardiopulmonary resuscitation. Am Surg. 2009; 75: 626-627.
8. Ball CG, Sutherland FR, Dixon E, et al. Surgical trauma referrals from rural level III hospitals: should our community colleagues be doing more or less? J Trauma. 2009; 67: 180-184. doi: 10.1097/TA.0b013e3181a595c3
9. Ball CG, Rajani RR, Salomone JP, Vercruysse GA. The utility of sugar for complicated wounds: an old solution worth revisiting. Surg Infect (Larchmt). 2009; 21. doi: 10.1089/sur.2008.032
10. Ball CG, Kirkpatrick AW, Rajani RR, et al. Temporary intravascular shunts: when are we really using them according to the NTDB? Am Surg. 2009; 75: 605-607.
11. Moore TM, Cruze Dm, Wyrzykowski AD, Rajani RR, Davila MC. Informed consent in emergent surgery and unplanned surgery. J Ortho. 2009; 6: e8.
12. Rajani RR, Ball CG, Montgomery SP, Wyrzykowski AD, Feliciano DV. Airway management for victims of penetrating trauma: analysis of 50,000 cases. Am J Surg. 2009; 198: 863-867. doi: 10.1016/j.amjsurg.2009.08.013
13. Ball CG, Dente CJ, Kirkpatrick AW, et al. Occult pneumothoraces in victims of penetrating trauma: does mechanism matter? Can J Surg. 2010; 53: 251-255.
14. Ball CG, Sutherland FR, Kirkpatrick AW, et al. Dramatic innovations in modern surgical subspecialties. Can J Surg. 2010; 53: 335-341.
15. Arthurs ZM, Lyden SP, Rajani RR, Clair DG, Eagleton MJ. Long-term outcomes of Palmaz stent placement for intraoperative type 1a endoleak during endovascular aneurysm repair. Ann Vasc Surg. 2010; 25: 120-126. doi: 10.1016/j.avsg.2010.08.004
16. Rajani RR, Authurs ZM, Srivastava SD, Lyden SP, Clair DG, Eagleton MJ. Repairing immediate proximal endoleaks during abdominal aortic aneurysm repair. J Vasc Surg. 2011; 53(5): 1147-1147. doi: 10.1016/j.jvs.2010.11.095
17. Dubose JJ, Rajani RR, Gilani R, et al. Endovascular management of axillo-subclavian arterial injury: a review of published experience. Injury. 2012; 43(11): 1785-1792. doi: 10.1016/j.injury.2012.08.028
18. Fox N, Rajani RR, Bokhari F, et al. Eastern Association for the Surgery of Trauma. Evaluation and management of penetrating lower extremity arterial trauma: an Eastern Association for the Surgery of Trauma practice management guideline. J Trauma Acute Care Surg. 2012; 73: S315-S320.
19. Allemang MT, Rajani RR, Nelson PR, Hingorani A, Kashyap VS. Prescribing patterns of antiplatelet agents are highly variable after lower extremity endovascular procedures. Ann Vasc Surg. 2013; 27(1): 62-67. doi: 10.1016/j.avsg.2012.05.001
20. Rajani RR, Johnson LS, Brewer BL, et al. Anatomic characteristics of aortic transection: centerline analysis to facilitate graft selection. Ann Vasc Surg. 2014; 28(2): 433-436. doi: 10.1016/j.avsg.2013.06.029
Director, Skull base & Cerebrovascular laboratory
Assistant professor, Departments of Neurosurgery and Otolaryngology HNS
University of California, San Francisco, HSW 780
San Francisco, CA 94143, USA
Dr. Arnau Benet is director and principal investigator of the Skull Base and Cerebrovascular Laboratory. He is specialized in minimally invasive surgical research in neurosurgery, otolaryngology, and head and neck surgery. Dr. Benet has designed a surgical simulation method to accurately recreate operative scenarios in the laboratory. His laboratory investigations study surgical anatomy of microsurgical and endoscopic approaches to brain tumors and cerebrovascular lesions. He uses cutting-edge technology to compare approaches and design novel surgical trajectories.
Dr. Benet has designed a novel method for surgical simulation of challenging brain aneurysm surgery that includes 3D modeling and printing of aneurysm replicas from patients. His clinical research includes surgical outcomes and efficiency in neurosurgery and otolaryngology. His main research goals are to design novel minimally invasive surgical strategies for treatment of complex brain lesions.
Dr. Benet is expert in 3D surgical anatomy. His educational impact includes interactive 3D lectures on surgical anatomy to neurosurgery and otolaryngology residents and national and international conferences. He also teaches anatomy in the school of medicine. His main educational objective is to increase surgical safety by raising awareness of the critical anatomic structures encountered in the neurosurgical and otolaryngology procedures.
KEYWORDS/AREAS OF INTEREST
• 3D imaging applied to surgical neuroanatomy research and Education
• Endoscopic and Microscopic surgical simulation of the skull base: Expanded (coronal and sagittal planes) Endoscopic Endonasal approaches to the skull base and Transcranial approaches to the anterior, middle and posterior fossa. Endoscope assisted microneurosurgery
• Stereotactic morphometry in neurosurgical and OHNS research
• Embalming procedure design and post-mortem vascular ﬂow simulation for surgical training and vascular neurosurgery research
• High-deﬁnition Fiber Tractography of the Human Brain. • Diffusion Tensor Magnetic Resonance Imaging white matter reconstruction and macroscopic white matter dissection
HONORS AND AWARDS
• 2004 Elected medical student representative and class leader Faculty of Medicine, University of Barcelona
• 2005 Class President Faculty of Medicine, University of Barcelona
• 2006 Class President Faculty of Medicine, University of Barcelona
• 2007 Class President Faculty of Medicine, University of Barcelona
• 2008 Class President Faculty of Medicine, University of Barcelona
• 2008 Gemma Rosell national students research award Faculty of Medicine, University of Barcelona AND The gemma Rosell i romero foundation
PEER REVIEWED PUBLICATIONS
1. Notaris M, Cavallo L, Galino A, et al. Endoscopic endonasal transclival approach and retrosigmoid approach to the clival and petroclival regions. Neurosurgery. 2009; 65(6(l)): 42-50. doi: 10.1227/01.NEU.0000347001.62158.57
2.Benet A, Ensenat J, Samii M, et al. The oculomotor nerve: microanatomical and endoscopic study. Neurosurgery. 2010; 66(3): 593-601. doi: 10.1227/01.NEU.0000365422.36441.C8
3. Benet A, Rincon J, Cavallo L, et al. The trochlear nerve: microanatomic and endoscopic study. Neurosurg Rev. doi: 10.1007/s10143-012-0426-x
4. Devasagayam S, Benet A, McDermott M. Two part pterional craniotomy. Technical note. 2012. doi: 10.7759/cureus.69
5.Benet A, Prevedello D, Torroella J, et al. Comparative Analysis of the transcranial Far Lateral and endoscopic endonasal Far Medial Approaches: Surgical Anatomy and Clinical Illustration. World Neurosurgery. 2013; Supp1878-8750(13): 00190-00193.doi: 10.1016/j.wneu.2013.01.091
6. Benet A, Prevedello D, Carrau R, et al. Comparative Analysis of the Transcranial.
7. Benet A, Torroella J, Lawton T , Sanchez J. Novel embalming solution for neurosurgical simulation in cadavers. The Journal of Neurological Surgery. 2013; JNS13-1857R1.doi: 10.3171/2014.1.JNS131857
8. Labib M, Prevedello D, Miranda J, et al. The medial opticocarotid recess. An anatomic study of an endoscopic. doi: 10.1227/NEU.0b013e318271f614
9. Saigal R, Benet A, Hoffman W, Lustig L, Cheung S, McDermott M. Rotational Pericranial Flap for Repair of Refractory Posterior Fossa Pseudomeningocele. Cureus. 2014; 153. doi: 10.7759/cureus.153
Adjunct Associate Professor
Medical Director and Senior Consultant, Pinnacle Spine & Scoliosis Centre
School of Physical and Mathematical Sciences, School of Chemical and Biomedical Engineering
Nanyang Technological University
3 Mount Elizabeth, Mt Elizabeth Medical Centre
04-07, 228510, Singapore
Dr. Hee Hwan Tak is an Adjunct Associate Professor with Nanyang Technological University. He did his spine surgery fellowship in the United States between 1999 to 2000. He spent 6 months in Tulane University in New Orleans, and 6 months in Louisville, where he was a clinical instructor in University of Kentucky, Lexington.
Currently, Dr Hee’s clinical practice is 100 percent on spinal disorders in the pediatric and adult population. He manages all types of spinal disorders, for example degenerative spine (including cervical spine or neck), spinal fractures, spinal tumor, spinal infections, spinal deformities (including scoliosis).
His services encompass non surgical management of spinal conditions, as well as surgery if clinically indicated. Surgical services available at Pinnacle Spine & Scoliosis Centre include cervical spine (neck) surgery, non fusion (including artificial disc replacement) surgery, scoliosis and spinal deformity surgery, minimally invasive spine surgery, spine tumor surgery, and revision spine surgeries.
His research interests are in degenerative spinal disease, in particular the basic science of intervertebral disc degeneration and regeneration. He is also involved in the evaluation of clinical outcomes after spinal surgeries.
• HMDP fellowship award spine surgery 1999-2000
• TTSH 9th Annual Scientific Meeting 2001 overall best paper award
• Singapore Orthopaedic Association Hong Kong ambassador November 2001
• 5 year Long Service Award National University Hospital 2002
• Yahya-Cohen Lecture 36th Singapore Malaysia Congress of Medicine August 2002
• Star Award Quality Convention National University Hospital January 2004
• Biographical sketch in 23rd edition of Whos Who in the World 2006
• Star Award Quality Convention National University Hospital March 2006
• Young Orthopaedic Investigator Award Babu JN Peng Y Tao HR Hee HT Wong HK 29th
• Annual Scientific Meeting of Singapore Orthopaedic Association November 2006
• 10 year Long Service Award National University Hospital 2007
• 1st prize Doctoral category in research presentation contest Faculty of Medicine University of Indonesia May 2007
• Star Award Quality Convention National University Hospital May 2007
• Best poster award - Bone marrow mesenchymal stem cell transplantation and intervertebral disc distraction reverse intervertebral disc degeneration in a rabbit model. Ismail Hee HT James Goh Wong HK. 15th Triennial Congress of APOA Seoul Korea September 2007
• JOA Congress 2008 Travel Award Winner -Effects of dynamic tension on degenerated human annulus fibrosus and nucleus pulposus cells an in vitro study. Hee HT Zhang JT Wong HK. The 81st Annual Congress of the Japanese Orthopaedic Association Sapporo Japan May 2008
• Excellent service award Star award 2008
• Excellent service award gold 2009
• Long Service Award National University of Singapore
• Member Singapore Orthopaedic Association
• Member Singapore Medical Association
• Member Medical Protection Society
• Member Singapore Medical Council
• President Singapore Back Society 2005-present
• Member North American Spine Society
• Member Asian Association for Dynamic Osteosynthesis
• Chairman AOSpine Spore chapter 2007-2010
• Council member AOSpine East Asia Board Member AO Spine International
• Corresponding Member Cervical Spine Research Society
• Member Cervical Spine Research Society Asia Pacific Section
• Active Member The International Society for the Study of the Lumbar Spine
• Member Spine Arthroplasty Society
• Associate Fellow Scoliosis Research Society
• Member Asia Pacific Orthopaedic Association
• Member SOA 22nd Annual Scientific Meeting organizing committeeSecretary Asia-Pacific Orthopaedic Association APOA Section of Paediatric and Spinal Surgery 2002 meeting Singapore
• Executive committee member 2001-2003 Singapore Back Society
• Editor Singapore Back Society newsletter
• Member AO Spine Course 2003 sub-committee
• Member AO Spine Course 2005 sub-committee
• Member AO Spine Course 2008 sub-committee
• Chairman AO Spine Course 2010 sub-committee
• Advisory panel Health Education Hub National University Hospital
• Member undergraduate education committee for Department of Orthopaedic Surgery
• Member curriculum review committee for Yong Loo Lin School of Medicine
• Member Pharmaceutical and Therapeutic Committee National University Hospital
• Secretary SOA 29th Annual Scientific Meeting organizing committee
• Secretary SOA Executive Committee 2006-2007
• Member Blood Usage Committee National University Hospital
• Advisor NUH Scoliosis Support Group
• Editor ORTHO-LINK
• Member Medical Specialist Panel of Work Injury Compensation Medical Board
• Panel of Medical Experts The Subordinate Courts of Singapore
• Regional Faculty AOSpine Asia Pacific
• Local organizing committee member 9th Interdisciplinary World Congress on Low Back & Pelvic Pain 2016 Singapore
1. Singh S, Hee HT, Low YP. Significance of the lateral epiphysis of the acetabulum to hip joint stability. J Pediatr Orthop. 2000; 20(3): 344-348.
2. Hee HT, Whitecloud TS, Myers L, Gaynor J, Roesch W, Ricciardi JE. SF-36 health status of workers compensation cases with spinal disorders. Spine J. 2001; 1: 176-182.
3. Hee HT, Wong HP, Low YP, Myers L. Predictors of outcome of floating knee injuries in adults. Acta Orthop Scand. 2001; 72(4): 385-394. doi: 10.1080/000164701753542050
4. Hee HT, Majd ME, Holt RT, Whitecloud TS, Pienkowski D. Complications of multilevel cervical corpectomies and reconstruction with titanium cages and anterior plating. J Spinal Disord Tech. 2003; 16: 1-8.
5. Hee HT, Castro FP, Majd ME, Holt RT, Myers L. Anterior/posterior lumbar fusion versus transforaminal lumbar interbody fusion: analysis of complications and predictive factors. J Spinal Disord. 2001; 14(6): 533-540.
6. Hee HT, Lee EH, Lee GSM. Gait and pedobarographic patterns of surgically treated clubfeet. J Foot Ankle Surg. 2001; 40(5): 287-294. doi: 10.1016/S1067-2516(01)80064-8
7. Nather AZ, Hee HT. New Frontiers in Spinal Surgery. In: Nather AZ, ed. Research Methodology in Orthopaedics and Reconstructive Surgery. Singapore, New Jersey, London, Hong Kong: World Scientific. 2001; 551-574.
8. Hee HT, Whitecloud TS III, Myers L. SF-36 Health Status and Oswestry Disability Index in Workers Compensation Patients with Neck Pain. In: Lewandrowski KU, Wise DL, Trantolo DJ, Yaszemski MJ, White AA III eds. Advances in Spinal Fusion. Molecular Science, Biomechanics, and Clinical Management. 2004; 279-291.
9. Hee HT, Majd ME, Holt RT, Pienkowski D. Better treatment of vertebral osteomyelitis by using posterior stabilization and titanium mesh cages. J Spinal Disord Tech. 2002; 15(2): 149-156.
10. Hee HT, Whitecloud TS, Myers L. Poor physical, mental health linked with workers comp. Orthopedics Today. 2002; 5(1): 35.
11. Hee HT, Majd ME, Holt RT, Myers L. Do autologous growth factors enhance transforaminal lumbar interbody fusion? Eur Spine J. 2003; 12: 400-407. doi: 10.1007/s00586-003-0548-5
12. Hee HT, Whitecloud TS, Myers L, Roesch W, Ricciardi JE. Do workers compensation patients with neck pain have lower SF-36 scores? Eur Spine J. 2002; 11(4): 375-381. doi: 10.1007/s00586-002-0431-9
13. Hee HT, Singh S, Chong SM, Myers L. Protective effects of growth hormone on physeal distraction – an experimental study on rabbits. J Pediatr Orthop Part B. 2003; 12: 332-337.
14. Wong HK, Hee HT, Yu ZR, Wong D. Results of thoracoscopic instrumented fusion versus conventional posterior instrumented fusion in adolescent idiopathic scoliosis undergoing selective thoracic fusion. Spine. 2004; 29: 2031-2038.
15. Hee HT, Whitecloud TS, Myers L. The effect of previous low back surgery on general health status - results from the National Spine Network initial visit survey of patients with low back pain. Spine. 2004; 29: 1931-1937.
16. Kulkarni A, Hee HT. Adjacent level discitis after anterior cervical discectomy and fusion (ACDF): a case report. Eur Spine J. 2006; 15(17): 559-563. doi: 10.1007/s00586-005-0003-x
17. Kulkarni A, Hee HT, Wong HK. Solis cage (PEEK) for anterior cervical fusion: Preliminary radiological results with emphasis on fusion and subsidence. Spine J. 2007; 7(2): 205-209. doi: http://dx.doi.org/10.1016/j.spinee.2006.03.002
18. Hee HT, Khan MS, Goh JC, Wong HK. Insertion torque profile during pedicle screw insertion of the thoracic spine with and without violation of the pedicle wall – comparison between cylindrical and conical designs. Spine. 2006; 31: E840-E846.
19. Hee HT, Yu ZR, Wong HK. Comparison of segmental pedicle screw instrumentation versus anterior instrumentation in adolescent idiopathic thoracolumbar scoliosis. Spine. 2007; 32: 1533-1542.
20. Hee HT. Current concepts in vertebroplasty and kyphoplasty. In: Lewandrowski, Yaszemski, Kalfas, Park, McLain, Trantolo eds. Spinal Reconstruction: clinical examples of applied basic science, biomechanics, and engineering. New York, London: Informa healthcare, Inc. 2007; 381-394.
21. Hee HT, Ismail, Lim CT, Goh J, Wong HK. Bone marrow mesenchymal stem cell transplantation and intervertebral disc distraction reverse intervertebral disc degeneration in a rabbit model. J Bone Joint Surg Br. 2010; 92(5): 726-736.
22. Hee HT, Zhang JT, Wong HK. Effects of cyclic dynamic tensile stress on pre-compressed annulus fibrosus and nucleus pulposus cells of human intervertebral disc- an in vitro study. J Orthop Res. 2010; 503-509.
23. Hee HT, Chuah YJ, Tan BHM, Setiobudi T, Wong HK. Vascularization and morphological changes of the endplate after axial compression and distraction of the intervertebral disc. Spine. 2011; 36(7): 505-511. doi: 10.1097/BRS.0b013e3181d32410.
24. Hee HT, Zhang JT, Wong HK. Effects of dynamic cyclic compression on human annulus fibrosus and nucleus pulposus cells -an in vitro stud. The Spine J. 2010; 10(9): 795-801.
25. Oh JY, Louange D, Rahmat R, Hee HT, Kumar VP. Paradoxical movement of L5S1 lumbar segment in spondylolytic spondylolisthesis. Eur Spine J. 2012; 21(2): 262-267. doi: 10.1007/s00586-011-1880-9
26. Tan BHM, Hee HT. Treatment of osteoporotic compression fractures with vertebroplasty. Osteoporosis: Etiology, Diagnosis, and Treatment. Hauppauge, NY: Nova Science Publishers, Inc. 2009.
27. Wang LS, Hee HT, Wong HK. Cervical Spondylotic Myelopathy: A brief review of its pathophysiology, presentation, assessment, natural history and management. Orthopaedics and Trauma. 2011; 25(3): 181-189. doi: 10.1016/j.mporth.2010.09.005
28. Lim CT, Hee HT. Stem cell therapy in Orthopaedic Surgery. Advances in Orthopaedics. 2010; 2(3): 81-88.
29. Zhu L, Chan YC, Hee HT, Wong HK. Paraspinal magnetic stimulation cerebral evoked potentials in treatment follow-up of low back pain. Journal of the Neurological Sciences. 2009(285(1)): S141.
30. Mishra A, Deng R, Loo Y, et al. Ultrasmall natural peptides self-assemble to strong temperature-resistant helical fibers in scaffolds suitable for tissue engineering. Nano Today. 2011; 6: 232-239. doi: 10.1016/j.nantod.2011.05.001
31. Ashwin A, Hey HW, Subramaniam R, Rehman AU, Hee HT. Clinical and radiological results of the Discover cervical disc replacement with minimum two-year follow-up. Journal of Spine and Neurosurgery. 2014; 3: 4.
32. Hey HW, Hee HT. A Review of Thoracolumbar Spine Fracture Classifications. Journal of Orthopaedics and Trauma. 2011; 1: 1-5. doi: 10.4303/jot/235406
33. Hey HWD, Hong CC, Long AS, Hee HT. Is hybrid surgery of the cervical spine a good balance between fusion and arthroplasty? Pilot results from a single surgeon series. Eur Spine J. 2013; 22(1): 116-122. doi: 10.1007/s00586-012-2486-6
34. Hey HW, Lau PH, Hong CC, Hee HT. Post-laminectomy spondylolisthesis – a review of the posterior elements and their contribution to the stability of the lumbar spine. The Open Spine Journal. 2012; 4: 5-9.
35. Hee HI, Tan YS, Hee HT. Postoperative analgesia after lumbar laminectomy: Is there a role for single shot epidural fentanyl?. The Spine J. 2012; 12(8): 652-625.
36. Kumar N, Chen Y, Nath C, Hee HT, Thambiah J. Anterior only decompression and instrumentation of stable thoracolumbar burst fractures: introduction of concept of hemi-corpectomy. J Bone Joint Surg Br. 2012; 94-B: 130.
37. Chuah YJ, Hee HT, Kang YJ. Cellular mechanotransduction in microfluidic systems. In: Li DQ ed. Encyclopedia of Microfluidics and Nanofluidics. New York/Heidelberg: Springer, Inc. 2013.
38. Soh RC, Hee HT. Scoliosis. Causes, Diagnosis and Treatment. In: Absolon Bessette, Coralie M Rousseau (eds) Scoliosis. Causes, Diagnosis and Treatment. NY: Nova Science Publishers. 2012; 91-104.
Assistant Professor of Surgery
Division of Transplant Surgery
Department of Surgery
Emory University School of Medicine
Emory Transplant Center
101 Woodruff Circle, WMB 5105
Atlanta, GA 30322, USA
Dr. Magliocca was the Surgical Director of Adult and Pediatric Liver Transplantation, Surgical Director of Pancreas Transplantation, and Director of both Resident Education and Medical Student Education, Transplant and Hepatobiliary Surgery, of the University of Florida College of Medicine. He received his MD at Mount Sinai School of Medicine in 1999, completed his general surgery residency at the University of Michigan Health System in 2004, and did his research and clinical fellowships in transplant surgery at the University of Wisconsin Hospital and Clinics from 2004-2007. His clinical interests are liver transplantation and hepatic malignancies.
His research specialties are organ preservation, ischemia/reperfusion injury, and the management of immunosuppression in patients following transplantation.
Honors, Awards andScholarships
• (2011) Department of Health and Human Services Organ Donation Bronze Medal of Honor
• (2004)Frederick A. Coller Clinical Tour
• (2002) The Bronze Beeper Student Teaching Award
• (2000) The Bronze Beeper Student Teaching Award
• (1998) Alpha Omega Alpha
• (1997) Mount SinaiSchool of Medicine Scholarship
• (1996) Rudin Scholarship Award
• (1995) Phi Beta Kappa Associates Award
• (1995) The American Institute of Chemists Foundation and The New York Institute of Chemists Award for Outstanding Achievement in Biochemistry
• (1995) National Collegiate Natural Sciences Award
• (1995) Chemistry Departmental Award
• (1995) CSI Auxiliary Services Corporation Award in Chemistry
• (1995) William C. LaMorte Order Sons of Italy in America, Anthony DiMarzio Memorial Scholarship Award
• (1995) M&L Strauss Memorial Scholarship
• (1995) CUNY Jonas Salk Scholar
• (1994) Summer Research Scholarship, Biochemistry
• (1994) Student Government Scholarship
• (1994-1995) Whos Who Among Students in AmericanUniversities and Colleges
• (1991-1995) Deans List, City University of New York
1. Squires M, Hanish S, Fisher S, et al. Transplant versus resection for the management of hepatocellular carcinoma meeting Milan Criteria in the MELD exception era at a single institution in a UNOS region with short wait times. J Surg Oncol. 2014; 109(6): 533-541. doi: 10.1002/jso.23531
2. Kayler L, Wen X, Zacharai M, Casey M, Schold J, Magliocca J. Response: Old-to-old pancreas transplantation, what’s old in the USA may be young in Europe. TransplInt. 2014; 27(4): e33. doi: 10.1111/tri.12260
3. Zachariah M, Gregg A, Schold J, Magliocca J, Kayler L. Alemtuzumab induction in simulaneous pancreas and kidney transplantation. Clin Transplant.2014; 27(5): 693-700. doi: 10.1111/ctr.12199
4. Kayler L, Wen X, Zacharai M, Casey M, Schold J, Magliocca J. Outcomes and survival analysis of old-to-old simultaneous pancreas and kidney transplantation. TransplInt. 2013; 26(10): 963-972.
5. Kayler L, Zendejas I, Schain D, Magliocca J. Ureteral stent placement and BK viremia in kidney transplant recipients. Transpl Infect Dis. 2013; 15(2): 202-207. doi: 10.1111/tid.12051
6. Kayler L, Zendejas I, Molmenti E, Chordia P, Schain D, Magliocca J. Kidney transplant ureteroneocystostomy: comparison of full-thickness vs. Lich-Gregoir Techniques. Clin Transplant. 2012; 26(4): E372-E380. doi: 10.1111/j.1399-0012.2012.01655.x
7. Cabrera R, Dhanasekaran R, Caridi J, et al. The impact of transarterial therapy in Hepatitis C related hepatocellular carcinoma on long-term outcomes after liver transplantation. Am J ClinOncol. 2012; 35(4): 345-350. doi: 10.1097/COC.0b013e31821631f6
8. Kayler L, Magliocca J, Zendejas I, Srinivas T, Schold J. Impact of cold ischemia time on graft survival among ECD transplant recipients: A paired kidney analysis. Am J Transplant. 2011; 11(12): 2647-2656. doi: 10.1111/j.1600-6143.2011.03741.x
9. Kayler L, Sokolich J, Magliocca J, Schold J. Import Kidney Transplants from Non-mandatory Share Deceased Donors: Characteristics, Distribution, and Outcomes. Am Jtransplant. 2011; 11(1): 77-85. doi: 10.1111/j.1600-6143.2010.03359.x
10. Kahan B, Magliocca J, Merriam F, et al. Elimination of tumorigenic stem cells from differentiated progeny and selection of definitive endoderm reveals a Pdx1+ foregut endoderm stem cell lineage. Stem Cell Research. 2011; 6: 143-157. doi: 10.1016/j.scr.2010.10.003
11. Sokolich J, Magliocca J, Kayler L. Import Kidney offers and DonorNet: a view from the trenches. Clin Transplant. 2011; 25(6): 856-863. doi: 10.1111/j.1399-0012.2010.01356.x
12. Kayler L, Schold J, Magliocca J. Response: Donor Net and the potential effects on organ utilization. Am J Transplant. 2010; 10(10): 2376. doi: 10.1111/j.1600-6143.2010.03197.x
13. Iida T, Takahashi M, Zendejas I, et al. Successful treatment of invasive mucormycosis in a liver transplant patient by arm amputation. Transplant Proc. 2010; 42(7): 2794-2796. doi: 10.1016/j.transproceed.2010.06.001
14. Hemming A, Magliocca J, Fujita S, et al. Combined resection of the liver and pancreas for malignancy. JACS. 2010; 210(5): 808-813. doi: 10.1016/j.jamcollsurg.2009.12.007
15. Guerra G, Indahyung R, Bucci C, Schold J, Magliocca J, Kriesche H. Elevated incidence of posttransplanterythrocytosis after simultaneous pancreas kidney transplantation. Am J Transplant. 2010; 10(4): 938-942. doi: 10.1111/j.1600-6143.2010.03012.x
16. Kayler L, Magliocca J, Kim R, Howard R, Schold J. Single Kidney Transplantation from Young Pediatric Donors in the United States. Am J Transplant. 2010; 9(12): 2745-2751. doi: 10.1111/j.1600-6143.2009.02809.x
17. Schold J, Santos A, Rehman S, Magliocca J, Kriesche H. The Success of Continued Steroid Avoidance after Kidney Transplantation in the US. Am J Transplant. 2009; 9(12): 2768-2776. doi: 10.1111/j.1600-6143.2009.02838.x
18. Kim RD, Zendejas I, Velopolous C, et al. Duplicate gallbladder arising from the left hepatic duct: Report of a case. Surg Today. 2009; 39(6): 536-539. doi: 10.1007/s00595-008-3878-4
19. Schold J, Rehman S, Kayler L, et al. Treatment for BK Virus: Incidence, risk factors and outcomes for kidney transplant recipients in the United States. TransplInt. 2009; 22(6): 626-634. doi: 10.1111/j.1432-2277.2009.00842.x
20. Kayler L, Garzon P, Magliocca J, et al. Outcomes and utilization of kidneys from deceased donors with acute kidney injury. Am J Transplant. 2009; 9(2): 367-373. doi: 10.1111/j.1600-6143.2008.02505.x
21. Iida T, Zendejas I, Kayler L, et al. Hepatocellular carcinoma in a 10 month old biliary atresia child. Ped Transplant. 2008; 13(8): 1048-1049. doi: 10.1111/j.1399-3046.2008.01094.x
22. Kayler L, Magliocca J, Fujita S, et al. Recovery factors affecting utilization of small pediatric donor kidneys. Am J Transplant. 2009; 9(1): 210-216. doi: 10.1111/j.1600-6143.2008.02447.x
23. Magliocca J, Odorico J, Pirsch J, et al. A comparison of alemtuzumab with basiliximab induction in simultaneous pancreas-kidney transplantation. Am J Transplant . 2008; 8: 1702-1710. doi: 10.1111/j.1600-6143.2008.02299.x
24. Magliocca J, Held I, Odorico J. Undifferentiated murine embryonic stem cells cannot induce portal tolerance but may possess immune privilege secondary to reduced MHC antigen expression. Stem Cells Dev. 2006; 15(5): 707-717. doi: 10.1089/scd.2006.15.707
25. Magliocca J, Knechtle S. The evolving role of alemtuzumab (Campath-1H) for immunosuppressive therapy in organ transplantation. TransplInt. 2006; 19: 705-714. doi: 10.1111/j.1432-2277.2006.00343.x
26. Treff N, Vincent R, Budde M, et al. Differentiation of embryonic stem cells conditionally expressing neurogenin 3. Stem Cells. 2006; 24(11): 2529-2537. doi: 10.1634/stemcells.2006-0082
27. Magliocca J, Odorico J. Embryonic stem cell based therapy for the treatment of diabetes mellitus: A work in progress. Curr Opin Organ Transplant. 2006; 11: 88-93. doi: 10.1097/01.mot.0000203883.87439.27
28. Magliocca K, Jabero M, Alto D, Magliocca J. Knowledge, beliefs and attitudes of dental and dental hygiene students toward obesity. J Dent Educ. 2005; 69(12): 1332-1339.
29. Magliocca J, Faerber G , Upchurch G. Solitary common iliac artery inflammatory aneurysm in a healthy woman: Case report and review of the literature. Ann VascSurg. 2005; 19(6): 890-895. doi: 10.1007/s10016-005-7713-8
30. Magliocca J, Magee J, Rowe S, et al. Extracorporeal support for organ donation after cardiac death effectively expands the donor pool. J Trauma. 2005; 58: 1095-1102.
31. Sheiner P, Magliocca J, Bodian C, et al. Long-term medical complications in patients surviving > or = 5 years after liver transplant. Transplantation. 2000; 69: 781-789.
32. Guy S, Magliocca J, Fruchtman S, et al. Transmission of factor VII deficiency through liver transplantation. TransplInt. 1999; 12: 278-280. doi: 10.1111/j.1432-2277.1999.tb01214.x
33. Wang H, He Y, Hsu K, Magliocca J, Storch J, Stark R. 1H, 15N and 13C resonance assignments and secondary structure of apo liver fatty acid-binding protein. J Biomol NMR .1998; 12: 197-199.
Associate Professor of Surgery
Division of Vascular Surgery
Department of Surgery
George Washington University Medical School
22nd and I Street, NW, 6th Floor
Washington, DC 20037, USA
Dr. James Laredo is board-certified in both Surgery and Vascular Surgery and is credentialed as both a Registered Vascular Technologist (RVT) and Registered Physician in Vascular Interpretation (RPVI) by the American Registry for Diagnostic Medical Sonography (ARDMS). He is an associate professor of surgery at The George Washington University School of Medicine & Health Sciences. His area of expertise is in both endovascular and open vascular surgery.
Dr. Laredo earned both his PhD in Physiology and MD degree at the University of Maryland School of Medicine. He completed his general surgery training in Boston at the Beth Israel Deaconess Medical Center/Harvard Medical School and vascular surgery fellowship at Loyola University Medical Center in Chicago. Dr. Laredo is a member of numerous medical and surgical societies including the Society for Vascular Surgery, the American Venous Forum, the American College of Surgeons, and the American Medical Association. He continues to be active in both clinical and translational research and was recently awarded the Peripheral Vascular Surgery Society Academic Award for research in 2006. He serves as director of The GW Medical Faculty Associates Vein Center in Reston, VA.
His research interests includes: Lower extremity revascularization, hemodialysis access surgery, and aortic surgery, Dr. Laredo also specializes in venous diseases and vascular malformations.
SOCIETIES AND HONORS
• Rho Chi Pharmacy Honor Society 1987
• Phi Kappa Phi Honor Society 1987
• American Medical Association 1996
• American College of Surgeons 1996
• Massachusetts Medical Society 1997
• Society for Vascular Surgery 2002
• Peripheral Vascular Surgery Society 2004
• Medical Society of Virginia 2004
• American College of Phlebology 2004
• American Venous Forum 2004
• University of Maryland Baltimore County, Catonsville, MD.
1. Scholastic Achievement Award Scholarship - 1983 to 1987
2. Honors Program - 1983
3. Honor Roll - Fall 1983, Spring and Fall 1984, Spring 1985
4. Sigma Pi Tau Honor Society - 1985
• University of Maryland School of Pharmacy, Baltimore, MD.
1. Academic Excellence Award (1986, 1987, 1988)
2. Rho Chi Honor Society (President 1987-88)
3. Phi Kappa Phi Honor Society - 1987
4. Outstanding Young Men of America - 1988
5. National Deans List - 1988
6. Certificate of Honor - 1988
7. High Honors Graduate - 1988
8. William Simon Memorial Prize - 1988 (Superior Work in Medicinal Chemistry)
• University of Maryland School of Medicine, Baltimore, MD.
1. MD-PhD Program Scholarship - 1988 to 1996
2. Travel Award - Short Term Research Training Program
3. Eastern Student Research Forum 1989, Miami, FL
4. Whos Who Among Rising Young Americans - 1991
5. Membrane Biology Program Traineeship
a) Department of Physiology .
b) July 1990 to June 1992
6. Travel Award - MD-PhD Program
a) Endocrine Society Meeting 1993, Las Vegas, NV
7. National Deans List - 1993
8. Travel Award - Dupont Merck Pharmaceutical Co.
a) Endocrine Society Meeting 1994, Anaheim, CA
9. Travel Award - Office of Student Research
a) American Federation for Clinical Research
b) Southern Meeting 1995, New Orleans, LA
10. National Institutes of Health Clinical Electives Program
a) National Cancer Institute, Bethesda, MD.
b) Surgical Oncology Clerkship, August 1995
11. Cambridge University School of Clinical Medicine .
a) Papworth Hospital, Papworth Everard, UK
b) Cardiothoracic Surgery Clerkship, February 1996
12. Merck Young Investigator Award - American Heart Association
a) Council for High Blood Pressure Research
b) 50th Annual Fall Conference 1996, Chicago, IL
13. Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
14. General Surgery Resident Teacher Award – June 2001 to June 2002
15. Loyola University Medical Center, Maywood, IL
16. William J. Von Liebig Foundation Award for Vascular Surgery Research
a) Southern Association for Vascular Surgery
b) 28th Annual Meeting 2004, Rio Grand, Puerto Rico
17. Georgetown University Medical Center, Washington, DC
18. Peripheral Vascular Surgery Society
a) Educational Grant Award
b) Basic Science Research 2006
Original papers in peer reviewed journals
1. Laredo J, Wolff VL, Lovett PS. Chloramphenicol Acetyltransferase specified by cat-86 relationship between the gene and the protein. Gene. 1988; 73: 209-214. doi: 10.1016/0378-1119(88)90327-7
2. Steiert JG, Pogell BM, Speedie MK, Laredo J. A gene coding for a membrane bound hydrolase is expressed as a secreted soluble enzyme in Streptomyces lividans. Bio technology. 1989; 7: 65-68. doi: 10.1038/nbt0189-65
3. Boulanger BR, Lilly MP, Hamlyn JM, Laredo J, Shurtleff D, Gann DS. Ouabain is secreted by the adrenal gland in awake dogs. American Journal of Physiology. 1993; 264: E413-E419.
4. Hamilton BP, Manunta P, Laredo J, Hamilton JH, Hamlyn JM. Ouabain a new adrenal steroid hormone. Current Opinion in Endocrinology and Diabetes. 1994; 1: 123-131. doi: 10.1055/s-2000-8140
5. Laredo J, Hamilton BP, Hamlyn JM. Ouabain is secreted by bovine adrenocortical cells. Endocrinology. 1994; 135: 794-797. doi: http://dx.doi.org/10.1210/endo.135.2.8033829
6. Hamlyn JM, Laredo J, Lu Z, Hamilton BP, Lighthall GK, Manunta P. Do putative endogenous digitalis-like factors have a physiological role? Hypertension. 1994, 24: 640-644. doi: 10.1161/01.HYP.24.5.640
7. Laredo J, Hamilton, BP, Hamlyn, JM. Secretion of endogenous ouabain from bovine adrenocortical cells role of the zona glomerulosa and zona fasciculata. Biochemical Biophysical Research Communications. 1995; 212: 487-493. doi: 10.1006/bbrc.1995.1996
8. Laredo J, Shah JR, Lu Z, Hamilton BP, Hamlyn JM. Angiotensin II stimulates secretion of endogenous ouabain from bovine adrenocortical cells via angiotensin type 2 receptors. Hypertension. 1997; 29(2): 401-407. doi: 10.1161/01.HYP.29.1.401
9. Shah JR, Laredo J, Hamilton BP, Hamlyn JM. Different signaling pathways mediate stimulated secretions of endogenous ouabain and aldosterone from bovine adrenocortical cells. Hypertension. 1998; 31(2): 463-468. doi: 10.1161/01.HYP.31.1.463
10. Hamlyn JM, Lu ZR, Manunta P, et al. Observations on the nature, biosynthesis, secretion and significance of endogenous ouabain. Clinical and Experimental Hypertension. 1998; 20(5(6)): 523-533.
11. Laredo J, Morris DJ, Thurer RL. Metastatic melanoma to the manubrium sternum. European Journal of Cardio-Thoracic Surgery. 1998; 16: 629-630. doi: 10.1016/S1010-7940(98)00248-6
12. Laredo J, Thurer RL, Burke PA, Archer SY. Case report a 70-year-old man with an empyema. Lancet. 1998; 352: 1982.
13. Shah JR, Laredo J, Hamilton BP, Hamlyn JM. Effects of angiotensin II on sodium potassium pumps, endogenous ouabain, and aldosterone in bovine zona glomerulosa cells. Hypertension. 1999; 33: 373-377. doi: 10.1161/01.HYP.33.1.373
14. Laredo J, Cooper JT. Soft Tissue Images. Meckels diverticulitis. Canadian Journal of Surgery. 1999; 42: 167.
15. Laredo J. Whats your diagnosis? General Surgery Quiz. Resident and Staff Physician. 1999; 45-56.
16. Laredo J, Filtzer HS. Right Colonic Intussusception. American Journal of Surgery. 2000; 179-485.
17. Hamlyn JM, Laredo J, Shah JR, Lu ZR, Hamilton BP. 11-Hydroxylation in the Biosynthesis of Endogenous Ouabain Multiple Implications. Annals of the New York Academy of Sciences. 2003; 986: 685-693. doi: 10.1111/j.1749-6632.2003.tb07283.x
18. Laredo J, Xue L, Husak VA, Ellinger J, Greisler HP. Silyl-heparin adsorption improves the in vivo thromboresistance of carbon-coated polytetrafluoroethylene vascular grafts. American Journal of Surgery. 2003; 186: 556-560. doi: http://dx.doi.org/10.1016/j.amjsurg.2003.07.015
19. Botnar RM, Perez AS, Witte S, et al. In-vivo molecular imaging of acute and subacute thrombosis using a fibrin binding MRI contrast agent. Circulation. 2004; 109: 2023-2029. doi: 10.1161/01.CIR.0000127034.50006.C0
20. Laredo J, Xue L, Husak VA, et al. Silyl-heparin bonding improves the patency and in vivo thromboresistance of carbon-coated polytetrafluoroethylene vascular grafts. Journal of Vascular Surgery. 2004; 39: 1059-1065. doi: 10.1016/j.jvs.2003.12.025
21. Leon L, Labropoulos N, Laredo J, Rodriguez HE, Kalman PG. To what extent has EVAR influenced AAA management in the state of Illinois? Journal of Vascular Surgery. 2005; 41: 568-574. doi: 10.1016/j.jvs.2005.01.005
22. Neville RF, Deaton DH, Laredo J. Distal vein patch bypass for limb salvage an option when no vein is available. Vascular Disease Management. 2006; 3: 230-234. doi: 10.1016/j.jvs.2008.12.052.
23. Lee BB, Laredo J, Deaton DH, Neville RF. New concept regarding lymphatic malformation. Phlebolymphology. 2007; 14: 158.
24. Lee BB, Laredo J, Lee TS, Huh SH, Neville RF. Terminology and classification of congenital vascular malformations. Phlebology. 2007; 22: 249-252.
25. Lee BB, Laredo J, Lee TS, Huh SH, Joe JH, Neville RF. Congenital vascular malformations general diagnostic principles. Phlebology. 2007; 22: 253-257.
26. Lee BB, Laredo J, Kim YW, Neville RF. Congenital vascular malformations general treatment principles. Phlebology. 2007; 22: 258-263.
27. Crago AM, Singh N, Deaton DH, Neville RF, Laredo J. Endovascular repair of a common iliac artery aneurysm using the Cook Zenith AAA endovascular graft converter. Vascular and Endovascular Surgery. 2008; 42: 54-57. doi: 10.1177/1538574407309317
28. Lee BB, Laredo J. Regarding Multidisciplinary approach in the management of a giant arteriovenous malformation in the right axillary region. Journal of Vascular Surgery. 2008; 48: 775-776. doi: 10.1016/j.jvs.2008.04.072
29. Lee BB, Kim YW, Kim DI, Hwang JH, Laredo J, Neville R. Supplemental surgical treatment to end stage stage IV-V of chronic lymphedema. Int Angiol. 2008; 27389-27395.
30. Lee BB, Laredo J, Neville R, Villavicencio JL. Endovascular management of takayasu arteritis is it a durable option? Vascular. 2009; 138-146. doi: 10.2310/6670.2009.00012
31. Lee BB, Bergan J, Gloviczki P, et al. Diagnosis and treatment of venous malformations consensus document of the International Union of Phlebology IUP-2009. Int Angiol. 2009; 28434-28451.
32. Laredo J, Lee BB, Neville RF. Endovenous thermal ablation of the anterior accessory great saphenous vein. Endovasc Today. 2010; 9336-9339.
33. Neville RF, Steinberg J, Babrowicz JC, Laredo J, Deaton DH, Attinger CE. SS16 A comparison of endovascular revascularization and bypass in regards to healing rates of ischemic wounds. Journal of Vascular Surgery. 2010; 51: 11S-12S. doi: http://dx.doi.org/10.1016/j.jvs.2010.02.057
34. Lee AB, Laredo J, Neville R. Embryological background of truncular venous malformation in the extracranial venous pathways as the cause of chronic cerebro spinal venous insufficiency. Int Angiol. 2010; 2995-2108.
35. Lee B, Andrade M, Bergan J, et al. International Union of Phlebology. Diagnosis and treatment of primary lymphedema. Consensus document of the International Union of Phlebology IUP-2009. Int Angiol. 2010; 29454-29470.
36. Lee BB, Laredo J, Neville R. Current status of lymphatic reconstructive surgery for chronic lymphedema it is still an uphill battle! Int J Angiol. 2011; 2073-2080. doi: 10.1055/s-0031-1279685
37. Li L, Najafi AH, Kitlinska JB, et al. Of mice and men neuropeptide Y and its receptors are associated with atherosclerotic lesion burden and vulnerability. J Cardiovasc Transl Res. 2011; 4351-4362. doi: 10.1007/s12265-011-9271-5
38. Lee BB, Laredo J. Contemporary role of lymphoscintigraphy we can no longer afford to ignore! Phlebology. 2011; 26177-26178. doi: 10.1258/phleb.2011.011e01
39. Lee BB, Laredo J, Neville R. Reconstructive surgery for chronic lymphedema a viable option, but. Vascular. 2011; 19195-19205. doi: 10.1258/vasc.2010.oa0287
40. Lee BB, Laredo J. Classification of congenital vascular malformations the last challenge for congenital vascular malformations. Phlebology. 2012; 267-269. doi: 10.1258/phleb.2012.012E04
41. Lee BB, Laredo J. Invited commentary. J Vasc Surg. 2012; 563815.
42. Lee B, Laredo J. Venous malformation treatment needs a birdseye view. Phlebology. 2013. doi: 10.1177/0268355513476219
43. Lee BB, Baumgartner I, Berlien HP, et al. Consensus Document of the International Union of Angiology IUA-2013. Current concept on the management of arterio-venous management. Int Angiol. 2013; 3219-3232.
Division of Plastic and Reconstructive Surgery
Barnes Jewish Hospital
Dr. Ethan Baughman grew up delivering calves, operating on dogs, and vaccinating livestock beside his father, a rural Kansas veterinarian. After graduating summa cum laude with a degree in biology from Kansas State University, Dr. Baughman entered the Medical Scientist Training Program at UT Southwestern Medical Center. As a student in the Immunology Graduate Program, his research focused on multiple sclerosis. During his third year at UT Southwestern Medical School, Dr. Baughman said he recognized the many opportunities opening up in face and hand transplantation. He wanted to be a part of this exciting new specialty. Dr. Baughman, who has accepted a plastic surgery residency at Barnes-Jewish Hospital in St. Louis, said he sees numerous possibilities in plastic surgery. He looks forward to the opportunity to help veterans and others who have lost limbs.
His research interests include vascularized composite tissue allotransplantation, temporomandibular joint disorder, economics of hand infections, functional rhinoplasty.
Positions and Honors
• 2005 Kansas State University-State Outstanding Academics Senior Award
• 2004 Senator Barry M. Goldwater Scholarship
• 2004 Kansas State University Division of Biology’s Most Promising Student
• 2013 The Rohrich Family Excellence in Plastic Surgery Award
• American Society of Plastic Surgeons
• Texas Medical Association
• Texas Medical Association Political Action Committee
• Dallas County Medical Society
Selected Peer-reviewed Publications
1. Cunnusamy K, Baughman EJ, Franco J, et al. Disease exacerbation of multiple sclerosis is characterized by loss of terminally differentiated autoregulatory CD8 T cells. Clin Immunol. 2014; 152(1(2)): 115-126.doi: 10.1016/j.clim.2014.03.005
2. Li M, Baughman E, Roth MR, Han X, Welti R, Wang X. Quantitative profiling and pattern analysis of triacylglycerol species in Arabidopsis seeds by electrospray ionization mass spectrometry. plant J. 2014; 77(1): 160-172.doi: 10.1111/tpj.12365
3. Baughman EJ, Mendoza JP, Ortega SB, et al. Neuroantigen-specific CD8 regulatory T cell function is deficient during acute exacerbation of multiple sclerosis. J Autoimmun. 2011; 36(2): 115-124. doi: 10.1016/j.jaut.2010.12.003
4. Shah J, Nandi A, Buseman CM, et al. Salicylic acid signaling in plant defense: the lipid connection. plant. 2004; (4): 391-393.
5. Devaiah SP, Roth MR, Baughman EJ, et al. Quantitative profiling of polar glycerolipid species from organs of wild-type Arabidopsis and a phospholipase Dalpha1 knockout mutant. Phytochemistry. 2006; 67(17): 1907-1924. doi: 10.1016/j.phytochem.2006.06.005
6. Buseman CM, Tamura P, Sparks AA, et al. Wounding stimulates the accumulation of glycerolipids containing oxophytodienoic acid and dinor-oxophytodienoic acid in Arabidopsis leaves. Plant Physiol. 2006; 142(1): 28-39. doi: http://dx.doi.org/10.1104/pp.106.082115
7. Baughman E, Pillai V, Frohman E, Karandikar N. Immune Regulatory Role for CNS-specific, Autoreactive CD8 T Cells in Multiple Sclerosis. Clinical Immunology. 2008; 127(1): 47 .
8. Pillai V, Baughman E, Karandikar N. Suppressive Property of Activated FOXP3 T Cells Revealed by a Novel Suppression Assay. Clinical Immunology. 2008; 127(1): 50.
9. Baughman E, Pillai V, Elliot F, Karandikar N. Immune Regulatory Role for CNS-Specific, Autoreactive CD8 T cells in Multiple Sclerosis. J Neuroimmunology. 2008; 203(2): 257.
10.Baughman E, Mendoza JP, Ortega SB, et al. Neuroantigen-specific CD8+ regulatory T-cell function is deficient during acute exacerbation of multiple sclerosis. Journal of Autoimmunity. 2011; 36(2): 115-124. doi: 10.1016/j.jaut.2010.12.003
11.Pillai V, Ortega SB, Wang CK, Karandikar NJ. While under the mentorship of the sponsor’s laboratory, Mr. Baughman contributed intellectually and conducted peripheral experiments in the following work: Acknowledgement in Transient regulatory T-cells: a state attained by all activated human T-cells. Clin Immunol. 2007; 123(1): 18-29.
Professor and Chair
Director, Penn State Hershey Animal Resource Program
Department of Comparative Medicine, H054
M.S. Hershey Medical Center
Penn State University College of Medicine
500 University Drive
Hershey, PA 17033, USA
• (1972-1976) Department of Biology Delaware Valley College of Science and Agriculture, Doylestown, Pennsylvania Degree conferred: B.S
• (1978-1982) School of Veterinary Medicine University of Pennsylvania Philadelphia, Pennsylvania Degree conferred: V.M.D
• (1989-1991) Postdoctoral Fellow, Laboratory Animal Medicine Department of Comparative Medicine The Pennsylvania State University College of Medicine The Milton S. Hershey Medical Center Hershey, Pennsylvania Degree conferred: MS
• (2007-Present) Professor, Department of Comparative Medicine The Milton S. Hershey Medical Center The Pennsylvania State University, Hershey, Pennsylvania
• (2006-Present) Chair, Department of Comparative Medicine The Milton S. Hershey Medical Center The Pennsylvania State University, Hershey, Pennsylvania
• (2006-Present) Director, Animal Resource Program College of Medicine The Milton S. Hershey Medical Center The Pennsylvania State University, Hershey, Pennsylvania
• (2006-Present) Attending Veterinarian College of Medicine The Milton S. Hershey Medical Center The Pennsylvania State University, Hershey, Pennsylvania
• (2004-2005) Interim Chair, Department of Comaprative Medicine The Milton S. Hershey Medical Center The Pennsylvania State University, Hershey, Pennsylvania
• (2000-2007) Associate Professor (tenured), Department of Comparative Medicine The Milton S. Hershey Medical Center The Pennsylvania State University, Hershey, Pennsylvania
• (1995-2004) Associate Director, Animal Research Facility Department of Comparative Medicine The Milton S. Hershey Medical Center The Pennsylvania State University, Hershey, Pennsylvania
• (1994-Present) Member, Graduate School Faculty, The Pennsylvania State University, University Park, Pennsylvania
• (1991-2000) Assistant Professor, Department of Comparative Medicine The Milton S. Hershey Medical Center The Pennsylvania State University, Hershey, Pennsylvania
• 1987-1989) Associate Veterinarian, Countryside Veterinary Hospital Flemington, New Jersey
• (1985-1987) Associate Veterinarian, Marne Veterinary Clinic Mount Holly, New Jersey
• (1983-1985) Associate Veterinarian, West Trenton Animal Hospital West Trenton, New Jersey
• (1982-1983) Staff Veterinarian, Columbus Central Veterinary Hospital and Emergency Clinic, Columbus, New Jersey
• (1977-1978) Histotechnologist, Department of Safety Assessment Merck Sharp and Dohme, West Point, Pennsylvania
• (1976-1977) Research Biologist, Department of Safety Assessment Merck Sharp and Dohme, West Point, Pennsylvania
His research interest related to surgical research include: experimental surgery, animal models, anesthesia and analgesia, and preclinical device testing.
•(1976) Magna Cum Laude graduate, Delaware Valley College
•(1987) Continuing Education Award New Jersey Veterinary Medical Association
•(1988) Continuing Education Award New Jersey Veterinary Medical Association
•(1996) Certificate of Merit for Scientific Exhibit, Radiological Society of North America
•(1997) Certificate of Merit for Scientific Exhibit, Radiological Society of North America
•(2012) The American Publishers Awards for Professional and Scholarly Excellence (PROSE)award for Single Volume Reference in Science; The Laboratory Rabbit, Guinea Pig, Hamster, and Other Rodents, Mark Suckow, Karla A. Stevens, and Ronald P. Wilson, editors
1. Wilson RP, Zagon IS, Larach DR, Lang CM. Antinociceptive properties of tiletamine-zolazepam improved by addition of xylazine or butorphanol. Pharmacol Biochem and Behav. 1992; 43: 1129-1133.
2. Wilson RP, Agon IS, Larach DR, Lang CM. Cardiovascular and respiratory effects of tiletamine-zolazepam. Pharmacol Biochem and Behav. 1993; 44: 1-8.
3. Lang CM, Wilson RP. Laboratory rat. Laboratornye Zhyvotnye (J Balt-LASA). 1993; 3: 101-110.
4. Book CBS, Wilson RP, Ng YC. Cardiac hypertrophy in the ferret increases expression of the NaWilson RP-KWilson RP-ATPase alpha1- but not alpha3-isoform. Am J Physiol. 266(Heart Circ. Physiol. 1994; 35: H1221-H1227.
5. Cardella JF, Wilson RP, Fox PS, Griffith JW. Evaluation of a second generation tantalum biliary stent in a canine model. J Vasc Intervent Radiol. 1995; 6: 397-403.
6. ORoark TS, Wilson RP. Use of the BAAM Mark VI for blind oral intubation in the rabbit. Cont Topics. 1995; 34: 54-56.
7. Skopets B, Wilson RP, Griffith JW, Lang CM. Ivermectin toxicity in young mice. Lab Anim Sci. 1996; 46: 111-112.
8. Schengrund CL, Griffith JW, Wilson RP, Chi X. Correlation of mineral dust-induced changes in the composition of a fraction enriched in lung surfactant with pulmonary histologic lesions in rats. Appl Occ Environ Hyg. 1996; 11: 928-933.
9. Post JH, Cardella JF, Wilson RP, et al. Experimental nonsurgical transcervical sterilization with a custom-designed platinum microcoil. J Vasc Intervent Radiol. 1997; 8: 113-118.
10. Wilson RP, Griffith JW. Mycotic Thromboses in Three Sheep Implanted with Biomedical Cardiac Devices. Lab Anim Sci. 1997; 47: 554-556.
11. Hopper KD, Gilchrist IC, Landis JR, et al. In vivo accuracy of two radiographic systems in the detection of Björk-Shiley convexo-concave heart valve outlet strut single leg separations. J Thorac Cardiovasc Surg. 1998; 115: 582-590.
12. HopperKD, Kasales CJ, Wise SW, et al. The optimization of helical thoracic CT. J. Comput. Assist. Tomogr. 1998; 22: 418-424.
13. Hopper KD, Iyriboz TA, Mahraj RPM, et al. CT bronchoscopy: optimization of imaging parameters. Radiology. 1998; 209: 872-877.
14. Ednie DL, Wilson RP, Lang CM. Comparison of two sanitation monitoring methods in an animal research facility. Cont Topics. 1998; 37: 71-74.
15. Wilson RP, McLaughlin PJ, Lang CM, Zagon IS. Temporal variation in cellular proliferation during recornification of mouse tail skin. Cell Prolif. 1998; 31: 191-201. doi: 10.1111/j.1365-2184.1998.tb01197.x
16. Brown DB, Cardella JF, Wilson RP , et al. Evaluation of a modified Arrow-Trerotola percutaneous thrombolytic device for treatment of acute pulmonary embolus in a canine model. J Vasc Intervent Radiol. 1999; 10: 733-740.
17. Hopper KD, Gilchrist IC, Landis JR, et al. The detection of Björk-Shiley convexo-concave heart valve outlet strut single leg separations: concensus image acquisition and interpretation using two different cineradiographic imaging technologies. Cardiology. 1999; 91: 96-101. doi: 10.1159/000006887
18. Wilson RP, McLaughlin PJ, Zagon IS, Lang CM. The opioid growth factor, Met5-enkephalin, inhibits DNA synthesis during recornification of mouse tail skin. Cell Prolif. 2000; 3363-3373.
19. Wilson RP, Griffith JW. Streptococcus suis endocarditis and meningitis in a sheep. Cont. Topics . 2000; 39: 43-46.
20. Charles R,. Sandirasegarane L, Yun J, et al. Ceramide-coated balloon catheters limit neointimal hyperplasia after stretch injury in carotid arteries. Circ Res. 2000; 87: 282-288. doi: 10.1161/01.RES.87.4.282
21. Lukic B, Zapanta CM, Khalapyan T, et al. The effect of left ventricular function and drive pressures on the filling and ejection of a pulsatile pediatric ventricular assist device in an acute animal model. ASAIO Journal. 2007; 53: 379-384. doi: 10.1097/MAT.0b013e31805881a9
22. Connell JM,. Khalapyan T, et al. Anticoagulation of juvenile sheep and goats with heparin, warfarin, and clopidrogel. ASAIO Journal. 2007; 53: 229-237.
23. Udar A, Pauliks L, Clark JB, et al. Penn State Hershey – Center for Pediatric Cardiovascular Research. Artificial Organs. 2009; 33: 883-887. doi: 10.1111/j.1525-1594.2009.00889.x
24. Carney EL, Clark JB, Myers JL, et al. Animal model development for the Penn State pediatric left ventricular assist device. Artificial Organs. 2009; 33: 953-957.
25. Boehm C, Carney EL, Tallarida RJ, Wilson RP. Midazolam enhances the analgesic properties of dexmedetomidine in the rat. Vet Anesth Analg. 2010; 37: 550-556. doi: 10.1111/j.1467-2995.2010.00565.x
26. Rosensteel SM, Wilson RP, et al. COL1A1 oligodeoxynucleotides decoy: biochemical and morphologic effects in an acute wound repair model. Exp Mol Pathol. 2010; 89: 307-313. doi: 10.1016/j.yexmp.2010.07.003
27. Koya V , Campbell AM, Wilson RP, et al. Outbreak of abdominal distension and obstipation in a C57BL/6J experimental autoimmune encephalomyelitis study. Vet Pathol. 2012; 49: 528-531. doi: 10.1177/0300985811429809
28. Maddineni S, Nichenametla S, Sinha R, Wilson RP, Richie JP. Methionine restriction affects oxidative stress and glutathione-related redox pathways in the rat. Exp Biol Med. 2013; 238: 392-399. doi: 10.1177/1535370213477988
Assistant Professor of Surgery
CVRC, Rhode Island Hospital
Alpert Medical School of Brown University
Coro West 5th Floor, Room 5.235
1 Hoppin Street, Providence RI 02903, USA
Dr. Feng is a graduate of Henan Medical University with special training in cardiovascular surgery in China. Dr. Feng then received his PhD in Physiology from University of Montreal, Canada and finished his postdoctoral training at Department of Surgery, School of Medicine, SUNY at Buffalo. Dr. Feng was then recruited as Research Assistant Professor of Surgery at School of Medicine, University of Miami, as Instructor of Surgery at BIDMC, Harvard Medical School. Dr. Feng is currently an Assistant Professor of Surgery at Warren Alpert Medical School of Brown University and at Department of Surgery, Cardiovascular Research Center, Rhode Island Hospital.
Dr. Feng serves as PI and co-investigator on grants funded by the Rhode Island Foundation and National Institute of Health. He has published 105 peer-review/editorial articles/book chapters and 112 abstracts as first authors and co-authors. He has served as an editorial member and peer reviewer for a number of scientific journals in cardiovascular and surgical research.
His research interests include: Patho-physiology of cardiopulmonary bypass, heart failure, myocardial infarction, myocardial engineering, peri-operative myocardial protection during cardiovascular surgery of adult and children.
• Planta Medica, Annals of Thoracic Surgery, Circulation, Journal of Thoracic and Cardiovascular Surgery, Journal of Cardiovascular Surgery, International Journal of Medical Science
• Surgery, Biochimica et Biophysica Acta (BBA): General Subjects, Journal of Pediatric Intensive Care
• Editorial Board Member: Austin Journal of Surgery
MEMBERSHIP IN PROFESSIONAL SOCIETIES
• American Heart Association
• American Physiology Society
• International Society for Heart Research
Original Publications in Peer-Reviewed Journals
1. Feng J, Atanasiu R, Yamaguchi N, Lamontagne D, Chahine R, Nadeau R. Effects of ischemic preconditioning and hypothermia on ischemic contracture in the isolated rat heart. Medical Science Research. 1995; 23: 787-788.
2. Feng J, Wu GZ, Tang SB, Chahine R, Lamontagne D. Beneficial effects of iloprost cardioplegia in the ischemic arrest in isolated working rat heart. Prostaglandins Leukotrience Essential Fatty Acids. 1996; 62: 279-283. doi: http://dx.doi.org/10.1016/S0952-3278(96)90059-9
3. Feng J, Liu RY, Wu GZ, Tang SB. Pretreatment with tetramethylpyrazine increases the release of PGI2 and decreases TXA2 release in isolated rat heart. Planta Medicas. 1996; 62: 379-381. doi: 10.1055/s-2006-957915
4. Feng J, Liu RY, Wu GZ, Tang SB. Tetramethylpyrazine reduces cardiac-derived TXA2 release in isolated working rat heart. Medical Science Research.1996; 24: 121-122.
5. Feng J, Liu RY, Wu GZ, Tang SB. Prostaglandin E1 (PGE1) reduces cardiac-derived TXA2 release in ischaemic arrest in isolated working rat heart. Internal Journal Cardiology. 1996; 55: 265-270. doi: 10.1016/0167-5273(96)02715-5
6. Feng J, Chahine R, Yamaguchi N, Lamontagne N, Nadeau R. Brief repetitive ischemia effects on norepinephrine release, functional recovery and arrhythmias in isolated perfused rat heart. Canadian Journal of Physiololgy and Pharmacology. 1996; 74: 1351-1358.
7. Feng J, Yamaguchi N, Chahine R, Lamontagne D, Nadeau R. Perfusate potassium: effect on ischemia-induced arrhythmias in preconditioning in the isolated rat heart. Medical Science Research. 1996; 24: 327-329.
8. Feng J, Yamaguchi N, Foucart S, Chahine R, Lamontagne D, Nadeau R. Transient ischemia inhibits nonexocytotic release of norepinephrine in the rat heart: Is bradykinin involved? Canadian Journal of Physiology and Pharmacology. 1997; 75: 665-670.
9. Feng J, Liu RY, Wu GZ, Tang SB. Effects of tetramethylpyrazine on the release of PGI2 and TXA2 in hypoxic rat heart. Molecular and Cellular Biochemistry. 1997; 167: 153-158. doi: 10.1023/A:1006837606488
10. Feng J, Wu GZ, Tang SB. The effects of tetramethylpyrazine on the incidence of arrhythmias and the release of PGI2 and TXA2 in the ischemic rat heart. Planta Medicas 1999; 65: 268-270. doi: 10.1055/s-2006-960774
11. Feng J, Rosenkranz ER. Bradykinin pretreatment preconditions the heart by tyrosine kinase mediated pathways. Annals of Thoracic Surgery. 1999; 68: 1567-1572. doi: 10.1161/CIRCULATIONAHA.104.524454
12. Feng J, Li HL, Rosenkranz ER. Pinacidil pretreatment extends ischemia tolerance of neonatal rabbit hearts. Journal Surgical Research. 2000; 90: 131-137. doi: http://dx.doi.org/10.1006/jsre.2000.5865
13. Feng J, Li HL, Rosenkranz ER. Bradykinin protects the rabbit heart after cardioplegia via NO-dependent pathways. Annals of Thoracic Surgery. 2000; 70: 2119-2124. doi: http://dx.doi.org/10.1016/S0003-4975(00)02148-2
14. Feng J, Chahine R, Nadeau R. Influence of extracellular potassium on the antiarrhythmic effect of global preconditioning in isolated perfused rat heart. Molecular and Cellular Biochemistry. 2000; 214: 75-80. doi: 10.1023/A:1007183311209
15. Feng J, Schaus BJ, Fallavollita J, Lee TC, Canty JM. Preload induces troponin I degradation independently of myocardial ischemia. Circulation. 2001; 103: 2035-2037. doi: 10.1161/01.CIR.103.16.2035
16. Feng J, Li HL, Rosenkranz ER. Diazoxide protects the rabbit heart following cardioplegic ischemia. Molecular and Cellular Biochemistry. 2002; 233: 133-138. doi: 10.1023/A:1015554211010
17. Feng J, Li HL, Rosenkranz ER. KATP channel opener protects neonatal rabbit heart better than St. Thomas solution. Journal of Surgical Research. 2003; 109: 69-73. doi: http://dx.doi.org/10.1016/S0022-4804(02)00064-1
18. Feng J, Bianchi C, Li JY, Sellke FW. Improved profile of bad phosphorylation and caspase 3 activation after blood vs crystalloid cardioplegia. Annals of Thoracic Surgery. 2004; 77: 1384-1390. doi: http://dx.doi.org/10.1016/j.athoracsur.2003.09.053
19. Feng J, Bianchi C, Li JY, Sellke FW. Bradykinin preconditioning improves coronary microvascular reactivity during cardioplegia-reperfusion. Annals of Thoracic Surgery . 2005; 79: 911-916. doi: http://dx.doi.org/10.1016/j.athoracsur.2004.09.017
20. Feng J, Bianchi C, Sandmeyer JL, Li JY, Sellke FW. Bradykinin preconditioning improves the profile of cell survival proteins and limits apoptosis after cardioplegic arrest. Circulation. 2005; 112(1): 190-195. doi: 10.1161/CIRCULATIONAHA.104.524454
21. Feng J, Bianchi C, Sandmeyer JL, Li JY, Sellke FW. Molecular indices of apoptosis after intermittent blood and crystalloid cardioplegic ischemia. Circulation. 2005; 112(1): 184-189. doi: 10.1161/CIRCULATIONAHA.104.526160
22. Feng J, Sellke ME, Ramlawi B, et al. Bradykinin induces microvascular preconditioning via opening of calcium-activated potassium channels. Surgery . 2006; 140: 192-197. doi: http://dx.doi.org/10.1016/j.surg.2006.05.002
23. Feng J, Yano K, Monahan-Earley R, et al. Vascular bed-specific endothelium -dependent vasomomotor relaxation in the hagfish, myxine glutinosa. American Journal of Physiology (Regulatory, Integrative and Comparative). 2007; 293: R894-R900.
24. Feng J, Liu YH, Clements RT, et al. Calcium-activated potassium channels contribute to human coronary microvascular dysfunction after cardioplegia arrest. Circulation. 2008; 118 (1): S46-S51. doi: 10.1161/CIRCULATIONAHA.107.755827
25. Feng J, Liu YH, Khabbaz KR, et al. Large conductance calcium-activated potassium channels contribute to the reduced myogenic tone of peripheral microvasculature after cardiopulmonary bypass. Journal of Surgical Research. 2009; 157: 123-128. doi: 10.1016/j.jss.2009.03.043
26. Feng J, Liu YH, Khabbaz KR, et al. Endothelin-1-induced contractile responses of human coronary arterioles via endothelin-A receptors and PKC-alpha signaling pathways. Surgery. 2010; 147: 798-804. doi: 10.1016/j.surg.2009.11.016
27. Feng, J, Scott MD, Monica L, Sellke, FW, Ferran CJ, Abid R. Endothelium-dependent coronary vasodilatation requires NADPH oxidase-derived ROS. Arterioscler Thromb Vasc Biol. 2010; 30: 1703-1710. doi: 10.1161/ATVBAHA.110.209726
28. Feng J, Chu LM, Robich M, et al. Endothelin-1 induced contraction and signaling in the human skeletal muscle microcirculation. Circulation . 2010; 122: S150-S155.
29. Feng, J, Liu YH, Khabbaz K, et al. Decreased contractile response to endothelin-1 of peripheral microvasculature from diabetic patients. Surgery . 2011; 149: 247-252. doi: 10.1016/j.surg.2010.07.003
30. Feng, J, Liu YH, Singh AK, et al. Impaired contractile response of human peripheral arterioles to thromboxane A-2 after cardiopulmonary bypass. Surgery. 2011; 150: 263-271. doi: 10.1016/j.surg.2011.06.004
31. Feng, J, Liu YH, Chu LM, et al. Thromboxane induced contractile response of human coronary arterioles is diminished post-cardioplegic arrest. Annals of Thoracic Surgery . 2011; 92: 829-836. doi: 10.1016/j.athoracsur.2011.04.049
32. Feng, J, Chu LM, Dobrilovic N, Liu YH, Singh AK, Sellke FW. Decreased coronary microvascular reactivity after cardioplegic arrest in patients with uncontrolled diabetes mellitus. Surgery. 2012; 152: 282-289. doi: 10.1016/j.surg.2012.04.009
33. Feng, J, Liu YH, Chu LM, et al. Changes in microvascular reactivity after cardiopulmonary bypass in patients with poorly controlled versus controlled diabetes. Circulation. 2012; 126: S73-S80. doi: 10.1161/CIRCULATIONAHA.111.084590
34. Feng J, Liu YH, Dobrilovic N, et al. Altered apoptosis-related signaling after cardioplegic arrest in patients with uncontrolled type 2 diabetes. Circulation. 2013; 128: S144 -S151. doi: 10.1161/CIRCULATIONAHA.112.000332.
35. Feng J, Liu YH, Dobrilovic N, et al. Altered expression and activation of mitogen-activated protein kinases in diabetic heart during cardioplegic arrest and cardiopulmonary bypass. Surgery. 2013; 154: 436-443. doi: 10.1016/j.surg.2013.05.016
36. Chahine R, Feng J. Protective effects of taurine against reperfusion-induced arrhythmias in isolated ischemic rat heart. Arzneim Forch/Drug Res. 1998; 48: 360-364.
37. Thomas S, Fallavollita J, Lee TC, Feng J, Canty JM Jr. Absence of troponin I degradation or altered sarcoplasmic reticulum uptake protein expression following reversible ischemia in swine. Circulation Research. 1999; 85: 446-456. doi: 10.1161/01.RES.85.5.446
38. Voisine P, Bianchi C, Ruel M, et al. Inhibition of the cardiac angiogenic response to exogenous vascular endothelial growth factor. Surgery . 2004; 136: 407-415. doi: http://dx.doi.org/10.1016/j.surg.2004.05.017
39. Khan TA, Bianchi C, Voisine P, et al. Reduction of myocardial reperfusion injury by aprotinin after regional ischemia and cardioplegic arrest. Journal of Thoracic and Cardiovascular Surgery . 2004; 128: 602-608. doi: http://dx.doi.org/10.1016/j.jtcvs.2004.02.037
40. Voisine P, Bianchi C, Khan TA, Ruel et al. Normalization of coronary microvascular reactivity and improvement in myocardial perfusion by surgical VEGF therapy combined with oral supplementation of L-arginine in a porcine model of endothelial dysfunction. Journal of Thoracic and Cardiovascular Surgery . 2005; 129: 1414-1420. doi: http://dx.doi.org/10.1016/j.jtcvs.2004.12.046
41. Khan TA, Bianchi C, Voisine P, Sandmeyer JL, Feng J, Sellke FW. Aprotinin inhibits protease-dependent platelet aggregation and thrombosis. Annals of Thoracic Surgery . 2005; 79: 1545-1550.
42. Khan TA, Bianchi C, Araujo E, et al. Aprotinin preserves coronary cellular junctions and reduces myocardial edema after regional ischemia and cardioplegic arrest. Circulation . 2005; 112(1): 196-201.
43. Voisine P, Li J, Bianchi C, et al. Effects of L-arginine on FGF-2-induced angiogenesis in a model of endothelial dysfunction. Circulation . 2005; 112(1): 121-127. doi: 10.1161/CIRCULATIONAHA.104.526350
44. Nakai Y, Voisine P, Bianchi C, et al. Effects of L-arginine on the endogenous angiogenic response in a model of hypercholesterolemia. Surgery. 2005; 138: 291-298. doi: http://dx.doi.org/10.1016/j.surg.2005.06.013
45. Boodhwani M, Cohn WE, Feng J, et al. Safety and efficacy of novel gel for vascular occlusion in off-pump surgery. Annals of Thoracic Surgery . 2005; 80: 2333-2337. doi: http://dx.doi.org/10.1016/j.athoracsur.2005.05.031
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98. Feng J, Sellke FW. Pravastatin improves remodeling and cardiac function after myocardial infarction by an anti-inflammatory mechanism rather than by the induction of angiogenesis (Invited Commentary). Annals of Thoracic Surgery. 2006: 81: 2225-2226.
99. Feng J, Sellke FW. Enhanced angiogenesis with multimodal cell-based gene therapy (Invited Commentary). Annals of Thoracic Surgery. 2007; 83: 1119-1120.
100. Feng J, Sellke FW. Heat Shock proteins 27, 60, 70, 90S and 20S proteasome in on- versus off-pump coronary artery bypass graft patients. Annals of Thoracic Surgery. 2008; 85: 87-88.
101. Feng J, Sellke FW. Tight glycemic control protects the myocardium and reduces inflammation in neonatal heart surgery.Annals of Thoracic Surgery. 2010; 90: 30.
102. Feng J. Endothelium-dependent vasoconstrictions in isolated vessel grafts: a novel mechanism of vasospasms? Annals of Thoracic Surgery . 2011; 92: 1307.
103. Feng J, Sellke FW. Transforming growth factor-alpha enhances stem cell- mediated post-ischemic myocardial protection. Annals of Thoracic Surgery. 2011; 92: 1726.
104. Feng J. Mammalian fetal Cardiac regeneration following myocardial infarction is associated with differential gene expression compared to the adult. Annals of Thoracic Surgery. 2014; 97(5): 1650-1651.