Editorial Board


Pulmonary Research and Respiratory Medicine - Open Journal


Rahul K. Verma, PhD

Scientist-C
Department of Science and Technology
Office- Room-15
Institute of Nano Science and Technology Habitat Centre
Phase- 10, Sector- 64
Mohali, Punjab-160062, India

BiographyResearch InterestScientific ActivitiesPublications

Dr. Verma is a Scientist at Institute of Nano Science and Technology (INST), a premier autonomous institute of Department of Science and Technology (DST), Government of India. He received his PhD from Central drug Research Institute (CDRI), Lucknow, India and MS from the National Institute of Pharmaceutical Education and Research (NIPER), Mohali, both in Pharmaceutical sciences. He performed postdoctoral research at University of Oklahoma, USA. Dr. Verma also worked as Visiting Researcher sponsored by Royal Society of United Kingdom, at Bradford University, Bradford, United Kingdom. He is a recipient of the CDRI incentive award and two times recipient of BRG-France travel award. Dr. Verma has published several research papers and book sections in highly reputed International Journals and books respectively.

His current research interests include: Engineered aerosol biomaterials for controlled delivery of drugs, peptides, and vaccines, Nanoscale manipulation of multiphase polymeric materials, Bio-inspired materials, Nanoparticles etc. It mainly involves designing, development and evaluation of polymeric inhalable particulate drug delivery systems (microparticles, Nanoparticles, Porous Nanoparticle Aggregates (PNAP)) for Pulmonary & Nasal administration. He is an expert in formulation development using spray drying, Spray freeze drying, supercritical fluid technology and microfluizider. In addition he conducted research in preclinical Pharmacokinetic, therapeutic and toxicological evaluation in cells lines and animal models.

HONORS/AWARDS/FELLOWSHIPS


• CSIR, INDIA-Royal Society of United Kingdom Fellowship UK-2009-2010-received to work in UK at Institute of pharmaceutical Innovation (IPI) Bradford University in year (2009-2010)
• Directors Special CDRI incentive award-2009-received for publication in high impact research journal Antimicrobial Agents and Chemotherapy (AAC) in research in year (2008)
• BRG-France travel Award- received to travel and present at Groningen University, THE NETHERLANDS in (2009)
• BRG-France travel Award- received to travel and present at Dublin City University, Dublin, IRELAND in (2008)
• CSIR-SRF-Qualified Senior Research Fellowship-2009 (Council of Scientific & Industrial Research (CSIR), INDIA
• CSIR-NET-LS -Qualified Lecturership (LS)-2005, National Eligibility test for Lecturership in Indian Universities
• GATE (Graduate Aptitude Test for Engineering) - Qualified in Pharmaceutical Sciences –(2004) organized by Indian Institute of Technology (IIT), INDIA
• NIPER-Fellowship-Qualified to pursue M.S. (Pharm.) at National Institute of Pharmaceutical Education and Research (NIPER), Mohali, INDIA (2003)

1. Ibrahim M, Verma RK, Garcia-Contreras L. Inhalation drug delivery devices: technology update (8). Medical devices-evidence and research. 2015; 131-139.
2. Verma RK, Garcia-Contreras L. In Vitro Comparison of Two Nasal Delivery Devices to Administer Dry Powders. Respiratory Drug Delivery (RDD). 2014; 156-161.
3. Verma RK, Germishuizen WA, Motheo MP, et al. Inhaled microparticles containing clofazimine are efficacious in the treatment of experimental tuberculosis in mice. Antimicrobial Agents and Chemotherapy (AAC). 2013; 57(2): 1050-1052. doi: 10.1128/AAC.01897-12
4. Verma RK, Singh AK, Mohan M, et al. Inhalable Microparticles Containing Nitric Oxide Donors: Saying NO to Intracellular Mycobacterium Tuberculosis. Molecular Pharmaceutics (Mol. Pharm). 2012; 9(11): 3183-3187. doi: 10.1021/mp300269g
5. Verma RK, Mukker JK, Singh RSP, Kumar K, Verma PRP, Misra A. Partial biodistribution and pharmacokinetics of isoniazid and rifabutin following pulmonary delivery of inhalable microparticles to Rhesus macaques. Molecular Pharmaceutics (Mol. Pharm). 2012; 9(4): 1011-1016. doi: 10.1021/mp300043f
6. Verma RK, Agrawal AK, Singh AK, et al. Inhalable microparticles of nitric oxide donors induce phagosome maturation and kill Mycobacterium. Tuberculosis. 2013; 93(4): 412-417. doi: 10.1016/j.tube.2013.02.012
7. Verma RK, Kaur J, Kumar K, Yadav AB, Misra A. Intracellular time course, Pharmacokinetics, and Biodistribution of Isoniazid and Rifabutin following Pulmonary delivery of inhalable Microparticles to Mice. Antimicrobial Agents and Chemotherapy (AAC). 2008; 52(9): 3195-3201. doi: 10.1128/AAC.00153-08.
8. Verma RK, Pandya S, Misra A. Loading and Release of Amphotericin-B from Biodegradable Poly (lactic-co-glycolic acid) Nanoparticles. Journal Biomedical Nanotechnology (JBN). 2011; 7: 118-120. doi: http://dx.doi.org/10.1166/jbn.2011.1230
9. Verma RK, Singh AK, Mohan M, Agrawal AK, Misra A. inhaled therapies for tuberculosis and the relevance of activation of lung macrophages by particulate drug delivery systems. Therapeutic Delivery (Ther Delv.). 2011; 2(6): 753-768.
10. Verma RK, Tripathy RK, Paul MK, Nayyar A, Jain R, Mukhopadhayay AK. Bacterial DNA gyrase is not the target of quinoline based anti-tubercular compounds. International Research journal of Pharmacy(IJRP). 2013; 4(1): 284-292.
11. Singodia D, Verma A, Verma RK, Mishra PR. Investigations on Alternate Approach to Target Mannose Receptors on Macrophages using 4-Sulfated N-Acetyl Galactosamine more Efficiently as Compared to Mannose Decorated Liposomes : An Application in Drug Delivery. Nanomedicine-Nanotechnology, Biology and Medicine. 2012; 8(4): 468-477. doi: 10.1016/j.nano.2011.07.002
12. Pandya S, Verma RK, Misra A. Nanoparticles Containing Nitric Oxide Donor with Antileishmanial Agent for Synergistic Effect Against Visceral Leishmaniasis. Journal Biomedical Nanotechnology (JBN). 2011; 7: 213-215.
13. Dwivedi P, Kansal S, Sharma M, et al. Exploiting 4-sulphate N-acetyl galactosamine decorated gelatin nanoparticles for effective targeting to professional phagocytes in vitro and in vivo. Journal of Drug Targeting (JDT). 2012; 20(10): 883-896. doi: 10.3109/1061186X.2012.725169
14. Kansal S,Tandon R, Verma A, et al. Surface coating of doxorubicin loaded nanocapsule with alginate enhances its therapeutic efficacy through Th1 type immune response in Leishmania donovani infected hamsters. British journal of Pharmacology (BJP).
15. Dubey PK, Singodia D, Verma RK, Vyas SP. RGD modified albumin nanospheres for tumour vasculature targeting. Journal Pharmacy and Pharmacology (JPP). 2011; 63(1): 33-40. doi: 10.1111/j.2042-7158.2010.01180.x
16. Yadav AB, Muttil P, Singh, Verma RK, Mohan M, Misra A. The devils advocacy: When and why inhaled therapies for tuberculosis may not work. Tuberculosis. 2010; 9, 65-66. doi: 10.1016/j.tube.2010.10.001
17. Kaur J, Muttil P, Verma RK, et al. Apparatus for Pulmonary Delivery of Microparticles as a Dry Powder Inhalation Targeting Lung and Airway Macrophages in Mice. European Journal of Pharmaceutical sciences (EJPS). 2008; 34: 56-65.
18. Yadav AB, Muttil P, Singh AK, Verma RK, Mohan M, Sinha SK, Misra A. Microparticles induce variable levels of activation in macrophages infected with Mycobacterium tuberculosis. Tuberculosis. 2010; 90: 188-196. doi: 10.1016/j.tube.2010.03.001.
19. Yadav AB, Sharma R, Muttil P, Singh AK, Verma RK, Mohan M, Patel SK, Misra A. Inhalable Microparticles Containing Isoniazid and Rifabutin Target Macrophages and Stimulate the Phagocyte to Achieve High Efficacy. Indian journal of Experimental Biology (IJEB). 2009; 469-474.

Abdelwahab Omri, PhD

Professor
Department of Chemistry and Biochemistry
Northern Ontario School of Medicine, East Campus
935 Ramsey Lake Road
Sudbury, ON P3E 2C6
Canada

BiographyResearch InterestScientific ActivitiesPublications

Dr. Abdel Omri obtained his PhD from Université de Montréal in 1996. After completing postdoctoral fellowships at McGill University and the University of Toronto (1996-1998), he spent more than 2 years as Research associate at NRC (institute of biological sciences in Ottawa) from 1998 to 2000.
Dr. Omri is currently Full Professor in the Department of Chemistry and Biochemistry with a cross appointment to the Department of Biology, the Biomolecular Sciences PhD Programme, School of Rural and Northern Health PhD Programme. Dr. Omris research interests are focused on Lipid-based drug and vaccine delivery systems.
His laboratory employs a multi-disciplinary approach to addressing the antimicrobial resistance to gram negative bacteria in cystic fibrosis patients and in medical devices implants. Dr. Omri is also involved in the education of undergraduate and graduate students through the coordination of several calendar courses in biochemistry, pharmacology and toxicology and pharmaceutical technology. In addition to research, Dr. Omri is actively involved in the research training of both undergraduate and graduate students.
Dr. Omri has served in administrative capacities in several international scientific societies. He has published over 50 peer-reviewed research articles over his career on various aspects of drug delivery and targeting in addition to several published book chapters and books (2). He has served on a number of Editorial Boards and Granting Agencies in Canada and abroad. Dr. Omri has 2 patents.

His research interests include: 1. Liposomal delivery of antisense oligonucleotides. Effect on P-glycoprotein function in multidrug resistant cells in vitro and in vivo studies. Cationic liposome formulations are used to promote the penetration of antisense oligonucleotides into the cell membrane and protect them from enzymatic degradation (nucleases).
2. Liposomal delivery of antimicrobial agents towards resistant bacterial pathogens: pulmonary and systemic infections. Construction of liposomes with high encapsulation efficiency, favorable antimicrobial release profile and enhanced bactericidal activity, to overcome the problem of bacterial resistance caused by low permeability of the bacterial cell envelope and by production of antimicrobial-inactivating enzymes.
3. Liposomal formulations of drugs and vaccine for oral delivery. Liposomes are used to protect the encapsulated agents from the harsh gastrointestinal milieu (low pH, phospholipases, and bile salts) and to enhance their absorption to the systemic circulation and to increase the efficacy of these agents while minimizing their frequency of administration. Special liposomal formulation will be prepared, characterized and assayed for their efficacy in vitro and in animal models.

Prof. A Omri is member of the following national and international societies:


• American Society of Pharmacology and Experimental Therapeutics
• American Society For Microbiology
• Canadian Society of Pharmacology and Therapeutics
• International Society of Liposomes
• Canadian Society of Pharmaceutical Sciences

Scholarly Contributions


1. Azghani AO, Neal K, Idell S, et al. Mechanism of fibroblast inflammatory responses to Pseudomonas aeruginosa elastase Microbiology (United Kingdom). 2014; 160(3): 547–555. doi: 10.1099/mic.0.075325-0
2. Alipour M, Suntres ZE. Liposomal antibiotic formulations for targeting the lungs in the treatment of Pseudomonas aeruginosa. Therapeutic Delivery. 2014; 5(4): 409-427. doi: 10.4155/tde.14.13
3. Appanna VP, Auger C, Thomas SC, Omri A. Fumarate metabolism and ATP production in Pseudomonas fluorescens exposed to nitrosative stress Antonie van Leeuwenhoek. International Journal of General and Molecular Microbiology. 2014; 106(3): 431-438. doi: 10.1007/s10482-014-0211-7
4. Alipour M, Lou Y, Zimmerman D, et al. A balanced IL-1β activity is required for host response to Citrobacter rodentium infection. PLoS ONE. 2013; 8(12). doi: 10.1371/journal.pone.0080656.
5. Alhariri M, Azghani A, Omri A. Liposomal antibiotics for the treatment of infectious diseases. Expert Opinion on Drug Delivery. 2013; 10 (11): 1515-1532. doi: 10.1517/17425247.2013.822860
6. Bignucolo A, Appanna VP, Thomas SC, et al. Hydrogen peroxide stress provokes a metabolic reprogramming in Pseudomonas fluorescens: Enhanced production of pyruvate. Journal of Biotechnology. 2013; 167(3): 309-315. doi: 10.1016/j.jbiotec.2013.07.002
7. Alipour M, Mitsopoulos P, Smith MG, Bolger G, Pucaj K, Suntres ZE. Safety and pharmacokinetic studies of liposomal antioxidant formulations containing N-acetylcysteine, α-tocopherol or γ-tocopherol in beagle dogs. Toxicology Mechanisms and Methods. 2013 23: 419-431. doi: 10.3109/15376516.2013.774079
8. Alipour M, Omri A, Lui EM, Suntres ZE. Co-administration of aqueous ginseng extract with tobramycin stimulates the pro-inflammatory response and promotes the killing of Pseudomonas aeruginosa in the lungs of infected rats. Canadian Journal of Physiology and Pharmacology. 2013; 91(11): 935-940. doi: 10.1139/cjpp-2013-0073
9. Alhajlan M, Alhariri M, Omri A. Efficacy and safety of liposomal clarithromycin and its effect on pseudomonas aeruginosa virulence factors. Antimicrobial Agents and Chemotherapy. 2013; 57: 2694-2704. doi: 10.1128/AAC.00235-13
10. Alipour M, Buonocore C, Omri A. Therapeutic effect of liposomal-N-acetylcysteine against acetaminophen-induced hepatotoxicity. Journal of Drug Targeting, 2013; 21: 466-473. doi: 10.3109/1061186X.2013.765443
11. Alipour M, Pucaj K, Smith MG. Toxicity of ricin toxin a chain in rats. Drug and Chemical Toxicology. 2013; 36(2): 224-230. doi: 10.3109/01480545.2012.710624
12. Liu JJ, Davis EM, Wine E, Lou Y. Epithelial cell extrusion leads to breaches in the intestinal epithelium. Inflammatory Bowel Diseases. 2013; 19: 912-921. doi: 10.1097/MIB.0b013e3182807600
13. Alhariri M, Omri A. Efficacy of liposomal bismuth-ethanedithiol-loaded tobramycin after intratracheal administration in rats with pulmonary Pseudomonas aeruginosa infection. Antimicrobial Agents and Chemotherapy. 2013; 57: 569-578. doi: 10.1128/AAC.01634-12
14. Sande L, Sanchez M, Montes J. Liposomal encapsulation of vancomycin improves killing of methicillin-resistant Staphylococcus aureus in a murine infection model. Journal of Antimicrobial Chemotherapy. 2012; 67: 2191-2194. doi: 10.1093/jac/dks212
15. Alipour M, Smith MG, Pucaj K. Acute toxicity study of liposomal antioxidant formulations containing N-acetylcysteine, α-tocopherol, and γ-tocopherol in rats. Journal of Liposome Research. 2012; 22: 158-167. doi: 10.3109/08982104.2012.662654
16. Buonocore C, Alipour M, Omri A . Treatment of ricin A-chain-induced hepatotoxicity with liposome- encapsulated N-acetylcysteine. Journal of Drug Targeting. 2011; 19: 821-829. doi: 10.3109/1061186X.2011.582645
17. Alipour M, Dorval C, Suntres ZE. Bismuth-ethanedithiol incorporated in a liposome-loaded tobramycin formulation modulates the alginate levels in mucoid Pseudomonas aeruginosa. Journal of Pharmacy and Pharmacology. 2011; 63: 999-1007. doi: 10.1111/j.2042-7158.2011.01304.x
18. Alipour M, Dorval C, Suntres ZE. Ginseng aqueous extract attenuates the production of virulence factors, stimulates twitching and adhesion, and eradicates biofilms of Pseudomonas aeruginosa. Canadian journal of physiology and pharmacology. 2011; 89: 419-427. doi: 10.1139/y11-057
19. Heney M, Alipour M, Vergidis D, Omri A. Effectiveness of liposomal paclitaxel against MCF-7 breast cancer cells. Canadian Journal of Physiology and Pharmacology. 2010; 88(12): 1172-1180. doi: 10.1139/Y10-097
20. Jia Y, Joly H, Omri A. Characterization of the interaction between liposomal formulations and Pseudomonas aeruginosa. Journal of Liposome Research. 2010; 20(2): 134-146. doi: 10.3109/08982100903218892

Ibrahim M. EL-Sherbiny, PhD

Associate Professor of Nanoscience
Director of Center for Nanomaterials Science
The University of Science and Technology
Zewail City, Egypt

BiographyResearch InterestScientific ActivitiesPublications

• Dr. Ibrahim M. El-Sherbiny earned his PhD degree in Drug Delivery in February 2007 from Massey University, New Zealand.
• From 2008 to 2010, he joined pharmaceuticals research groups as a post-doctoral fellow at the University of New Mexico, USA and Texas University, USA.
• Dr. El-Sherbiny’s academic acumen has been recognized by being offered a “Fulbright Fellowship” at the University of Michigan, Biomedical Engineering in 2009 and he has also awarded the prestigious “Egyptian State Incentive Award in Science” in 2012, and the “Venice Kamel Award for Scientific Creativity for Young Researchers in the field of Materials Science and its Applications” in 2013.
• From 2010-2011, he worked as Research Assistant Professor in the College of Pharmacy at the University of Texas, USA. He is currently holding the position of Associate Professor of Nanomaterials Science and Director of the Center for Materials Science at Zewail City of Science and Technology, Egypt.
• Dr. El-Sherbiny’s research focuses in particular on the design and development of new classes of “smart nano- and nano-in-micro- polymeric matrices” using advanced techniques, and evaluating these new structures as potential candidates in various biomedical applications including targeted drug delivery, sustained pulmonary drug release, tissue engineering and regenerative medicine.
• Dr. El-Sherbiny has about fifty peer-reviewed scientific papers, about same number of participations in international conferences. He the author of two books, seven book chapters, and several review articles. Besides, he is also a named inventor on eleven patents and patents applications in USA (4), UK (4), Europe (1) and Egypt (2).
• Dr. El-Sherbiny is a member of several scientific societies such as American Association of Pharmaceutical Scientists (AAPS), Biomedical Engineering Society (BMES), New Zealand Institute of Chemistry (NZIC) and Materials Research Society (MRS), USA, Egyptian Society for Polymer Science & Technology (ESPST). He is also a Fellow of Royal Society of Chemistry.

His research interests include:
• Development and in-vitro assessment of new respirable/swellable nano-in-microparticles as potential carriers with adequate aerodynamic characteristics that can confer sustained drug release in the lung.
• Synthesis of new amphiphilic polymers and development of novel self-assembled nanoparticles for intracellular gene delivery (Current focus: siRNA, miRNA delivery to the lung).
• Preparation of smart polymeric carriers (micro- & nanoparticles) for site-specific drug delivery, (Current focus: oral intestine-specific delivery of protein drugs and insulin)
• Enhancement of bioabsorption/bioavailability of water-insoluble drugs and natural therapeutics via polymeric nano-encapsulation.
• Chemical modification of natural polymers and in-vitro evaluation of their bioactivity (Current focus: anticancer activity of some new chitosan derivatives).
• Smart hydrogel matrices as biodegradable scaffolds for tissue engineering & regenerative medicine.
• Eco-friendly “Green” electrochemical synthesis, characterization, and in vitro evaluation of natural polymers-metals (Ag, Fe & Cu) hybrid nanoparticles and nanostructures for enhanced therapeutic activity.
• Preparation of smart magnetically-responsive nanoparticles for D. delivery & biomedical applications.

Honors and Awards:

• 4/2014 Best poster award: The 2014 Materials Research Society, MRS, Spring Meeting & Exhibition, San Francisco, California, USA, 21-25 April, 2014
• 3/ 2014 Honoring by Academy of Scientific Research and Technology (ASRT) & Minister of Scientific Research
• 9/2013 Venice Goda Award for Scientific Creativity for Young Researchers in the field of Materials Science and its Applications. (National Academy of Scientific Research, Egypt)
• 6/2012 Prestigious STATE Incentive Award in Science (National Academy of Scientific Research, Egypt)
• 11/2012 Appreciation Certificate & Medal from Mansoura University (Science Day 2012)
• 12/2011 Who’s Who in America (66th Edition, 2012)
• 7/2011 Who’s Who in the World (28th Edition, 2011)
• 7/2010 Rank of one of TOP 25 Hottest Articles (#24), For one of the published papers in (Int. J. of Pharmaceutics, USA, 2010)
• 2/2009 Fulbright Fellowship (School of Biomedical Engineering, Uni of Michigan, Ann Arbor, USA)
• 4/2007 Certificates of Best Posters, 3/2013 (Applied session, E), The 9th & 11th International Conference of Chemistry and its Role in Development, Sharm El-Sheikh, Egypt
• 6/2006 Travel Money, (Massey University) to visit research groups at University of Sharjah (UAE), University of Jordan (Amman, Jordan), Food Science Australia, FSA (Werribee) and University of Melbourne (Australia), Warwick University (England)
• 4/2006 IFS Graduate Research Fund (IFSGRF), Massey University to attend the Macro-group International Conference on Polymer Synthesis 2006, Warwick University, UK
• 1/2006 PhD. Scholarship, Massey University, Palmerstone North, New Zealand (exemption from the tuition fees with back dating of the Ph.D. registration to 1/4/2004
• 8/2005, Rank of one of TOP 25 Hottest Articles (#9, # 11), 2011 (Science Direct) for TWO of the published papers (Eur. Polym. J., UK, & International Journal of Pharmaceutics, USA)
• 1/2004 PhD. Scholarship, (Channel System), from Egypt Government to study abroad
• 8/1997 An Honor Certificate, Egyptian Army- Air Defense Force
• 9/1994 Appreciation Certificate, El-Dakahlia Governorate, Egypt (Top Scholar, FSc., Mansoura University)
• 6/1994 Appreciation Certificate, Egyptian Syndicate of Scientific Professions


Professional Membership:

• American Association of Pharmaceutical Scientists (AAPS) (2008-present)
• Biomedical Engineering Society (BMES), USA (2009-present)
• New Zealand Institute of Chemistry, NZIC-membership (2006-2011)
• Materials Research Society (MRS), USA (2013-present)
• Science Age Society (SAS), (2012-present)
• American Royal Society (2010-present)
• Egyptian-American Scientists Association (EASA)- Medical Committee (2012-present)
• Egyptian Organization for Scientific Research and Technology (Co-founder), (2012-present)
• Egyptian Chemical Society (2011-pesent)
• Egyptian Society for Polymer Science & Technology (ESPST), (2007-present)
• Center for Separation Science, Massey University, New Zealand (2004-present)

Peer-Reviewed International Journals:

1. Elkholi IE, Hazem NM, ElKashef WF, et al. Evaluation of Anti-cancer Potential of Capsaicin-Loaded Trimethyl Chitosan-Based Nanoparticles in HepG2 Hepatocarcinoma Cells. Nanomedicine & Nanotechnology. 2014; 5(6): 240. doi: 10.4172/2157-7439.1000240
2. Guzman-Villanueva, D, El-Sherbiny IM, Vlassov AV, Herrera-Ruiz D, Smyth HDC. Enhanced cellular uptake and gene silencing activity of siRNA molecules mediated by chitosan-derivative nanocomplexes. Int J Pharmaceutics. 2014; 473(1-2): 579-590. doi: 10.1016/j.ijpharm.2014.07.026
3. Du, J, El-Sherbiny IM., Smyth HDC. Swellable Ciprofloxacin-loaded nano-in-micro hydrogel particles for local drug delivery. AAPS PharmSciTech. 2014; 15(6): 1535-1544. doi: 10.1208/s12249-014-0176-x
4. El-Sherbiny IM, Yahia S, Messiery MA, Reicha FM. Preparation and physicochemical characterization of new nanocomposites based on β-type chitosan and nano-hydroxyapatite as potential bone substitute materials. Int J Polymeric Materials and Polymeric Biomaterials. 2014; 63: 213-220. doi: 10.1080/00914037.2013.830249
5. El-Fallal AA, Degla H, El-Sherbiny IM. Assessment of a newly prepared silver nanoparticles suspension on the adhesion of biofilm on various denture base resin materials. Egy Dental J. 2014; 60 (2): 1-11.
6. El-Negoly SA, El-Fallal AA, El-Sherbiny IM. A new modification for improving shear bond strength and other mechanical properties of conventional glass-ionomer restorative materials. J Adhesive Dentistry. 2014; 16(1):41-47. doi: 10.3290/j.jad.a30541
7. El Shahaby O, El Zayat M, Salih E, El-Sherbiny IM, Reicha FM. Evaluation of antimicrobial activity of water infusion plant-mediated silver nanoparticles. Nanomedicine & Nanotechnology. 2013; 4(4): 178. doi: 10.4172/2157-7439.1000178
8. El-Sherbiny IM, Abdel-Hamid MI, Rashad M, Ali ASM, Azab YA. New calcareous soil-alginate composites for efficient uptake of Fe(III): Mn(II) and As(V) from water. Carbohydrate Polymers. 2013; 96: 450-459. doi: 10.1016/j.carbpol.2013.04.021
9. Guzman-Villanueva D, El-Sherbiny IM, Herrera-Ruiz D, Smyth HDC. Design and in vitro evaluation of new nano-microparticulate system for enhanced aqueous-phase dissolution and bioavailability of curcumin. Biomedical Research International. 2013; 2013: 1-10. doi: http://dx.doi.org/10.1155/2013/724763
10. El-Sherbiny IM, Salih E, Reicha FM. Green synthesis of densely dispersed and stable silver nanoparticles using myrrh extract and evaluation of their antibacterial activity. J Nanostructure in Chemistry. 2013; 3: 8. doi: 10.1186/2193-8865-3-8
11. Abdel-Razik EA, Shehata AE, El-Sherbiny IM. Photoinduced grafting of methyl methacrylate onto dehydrochlorinated poly (vinyl chloride) using a combination of dimethylaniline and benzoyl peroxide as initiator system. Int J Research in Engineering and Science (IJRES). 2013; 1(8): 1-11.
12. El-Sherbiny IM, Smyth HDC. Controlled release pulmonary administration of curcumin using swellable biocompatible nano-microparticles systems. Molecular Pharmaceutics. 2012; 9(2): 269-280. doi: 10.1021/mp200351y
13. Reicha FM, Sarhan A, Abdel Hamid MI, El-Sherbiny IM. Preparation of silver nanoparticles in the presence of chitosan by electrochemical method. Carbohydrate Polymers. 2012; 89(1): 236-244. doi: 10.1016/j.carbpol.2012.03.002
14. El-Far M, Refaat M, El-Sherbiny IM. A comparative study between the anticancer activities of chitosan and carboxymethyl chitosan. Current Topics in Biochemical Research. 2012; 14(1): 35-43.
15. Dawidar AM, Abdel-Mogib M, El-Sherbiny IM, Saeed AA. Terpenes, steroids and shikiimates in Calligonum Comosum L. Man Journal of Biology. 2012; 211-224.
16. El-Sherbiny IM, Abdel-Hamid MI, Rashad M, Ali ASM, Azab YA. Preparation and Assessment of Enhanced Alginate-Based Composites as Potential Sorbents for Water Treatment. Journal of Environmental Sciences. 2012; 407-421.
17. El-Sherbiny IM, Smyth HDC. Smart magnetically-responsive hydrogel nanoparticles prepared by a novel aerosol-assisted method for biomedical and drug delivery applications. Journal of Nanomaterials. 2011; 2011: 1-13. doi: http://dx.doi.org/10.1155/2011/910539
18. El-Sherbiny IM, Abdel-Mogib M, Dawidar A, Elsayed A, Hugh DC. Smyth HDC. Biodegradable pH-responsive alginate-poly (lactic-co-glycolic acid) nano/micro hydrogel matrices for oral delivery of silymarin. Carbohydrate Polymers. 2011; 83: 1345-1354.
19. El-Far M, El-Shal M, Refaat M, El-Sherbiny IM. Anti-tumor activity and antioxidant role of a novel water soluble carboxymethyl chitosan-based copolymer. Drug Development and Industrial Pharmacy. 2011; 37(12): 1481-1490. doi: 10.3109/03639045.2011.587430
20. Guzman-Villanueva D, Smyth HDC, Herrera-Ruiz D, El-Sherbiny IM. A Novel aerosol method for the production of hydrogel particles. Journal of Nanomaterials. 2011; 2011: 1-10. doi: http://dx.doi.org/10.1155/2011/507508
21. El-Sherbiny IM, Smyth HDC. Biodegradable nano-micro carrier systems for sustained pulmonary drug delivery: (I) Self-assembled nanoparticles encapsulated in respirable/swellable semi-IPN microspheres. International Journal of Pharmaceutics. 2010; 395: 132-141. doi: 10.1016/j.ijpharm.2010.05.032
22. El-Sherbiny IM, Mcgill S, Smyth HDC. Swellable microparticles as carriers for sustained pulmonary drug delivery. Journal of Pharmaceutical Sciences. 2010; 99(5): 2343-2356. doi: 10.1002/jps.22003
23. El-Sherbiny IM, Smyth HDC. Novel cryomilled physically crosslinked biodegradable hydrogel microparticles as carriers for inhalation therapy. Journal of Microencapsulation: Micro and Nano carriers. 2010; 27(7): 561-572. doi: 10.3109/02652041003739840
24. El-Sherbiny IM, Smyth HDC. Photo-induced synthesis, characterization and swelling behavior of poly(2-Hydroxyethyl methacrylate) grafted carboxymethyl chitosan. Carbohydrate Polymers. 2010; 81: 652-659. doi: 10.1016/j.carbpol.2010.03.027
25. El-Sherbiny IM. Enhanced pH-responsive carrier system based on alginate and chemically modified carboxymethyl chitosan for oral delivery of protein drugs: preparation and in-vitro assessment. Carbohydrate Polymers. 2010; 80(4): 1125-1136. doi: 10.1016/j.carbpol.2010.01.034
26. El-Sherbiny IM, Abdel-Bary EM, Harding DRK. Preparation and in-vitro evaluation of new pH-sensitive hydrogel beads for oral delivery of protein drugs. Journal of Applied Polymer Science. 2010; 115: 2828-2837. doi: 10.1002/app.30881
27. El-Sherbiny IM, Elmahdy ME. Preparation, characterization, structure, and dynamics of carboxymethyl chitosan grafted with acrylic acid sodium salt. Journal of Applied Polymer Science. 2010; 118: 2134-2145. doi: 10.1002/app.32517
28. El-Sherbiny IM, Smyth HDC. Poly(ethylene glycol)/carboxymethyl chitosan-based pH-responsive hydrogels: Photo-induced synthesis, characterization, swelling and in-vitro evaluation as potential drug carriers. Carbohydrate Research. 2010; 345(14): 2004-2012. doi: 10.1016/j.carres.2010.07.026
29. Selvam P, El-Sherbiny IM, Smyth HDC. Swellable hydrogel particles for controlled release pulmonary administration of curcumin using propellant driven metered dose inhalers. Journal of Aerosol Medicine and Pulmonary Drug Delivery. 2010; 23: 1-10. doi: 10.1089/jamp.2010.0830
30. Mobarak HM, El-Sherbiny IM, Abdel-Mogib M. Triterpenoids and volatile components of Euphorbia Tirucalli. Mans Journal of Chemistry. 2010; 37(2): 43-52.
31. El-Sherbiny IM, Salama A, Sarhan AA. Ionotropically-crosslinked pH-sensitive IPN hydrogel matrices as potential carriers for intestine-specific oral delivery of protein drugs. Drug Development and Industrial Pharmacy. 2010; 37(2): 121-130. doi: 10.3109/03639045.2010.495754
32. El-Sherbiny IM. Synthesis, characterization and metal uptake capacity of a new carboxymethyl chitosan derivative. European Polymer Journal. 2009; 45: 199-210. doi: 10.1016/j.eurpolymj.2008.10.042
33. El-Sherbiny IM, Salama A, Sarhan AA. Grafting study and antifungal activity of a carboxymethyl cellulose derivative. International Journal of Polymeric Materials. 2009; 58: 453-467. doi: 10.1080/00914030902936519
34. Abdel Bary EM, Abdelaal MY, Kenawy IM, El-Sherbiny IM, Moawad E, Hussein NH. Purification of wastewater from heavy metal ions using modified polymers. Mans Journal of Chemistry. 2009; 36(1): 115-138.
35. Abdelaal MY, Abdel-Razik EA, Abdel-Bary EM, El-Sherbiny IM. Study on chitosan-poly(vinyl alcohol) interpolymeric pH-responsive hydrogel films for controlled drug delivery. Journal of Applied Polymer Science. 2007; 103: 2864-2874.
36. El-Sherbiny IM, Abdel-Bary EM, Harding DRK. Preparation and swelling study of a pH-dependent interpolymeric hydrogel based on chitosan for controlled drug release. International Journal of Polymeric Materials. 2006; 55: 789-802. doi: 10.1080/00914030500440245
37. El-Sherbiny IM, Abdel-Bary EM, Harding DRK. Swelling characteristics and in-vitro drug release study with pH and thermo-sensitive hydrogels based on modified chitosan. Journal of Applied Polymer Science. 2006; 102: 977-985.
38. El-Sherbiny IM, Lins RJ, Abdel-Bary EM, Harding DRK. Preparation, characterization, swelling and in-vitro drug release behavior of poly [N-acryloylglycine-chitosan] interpolymeric pH and thermally-responsive hydrogels. European Polymer Journal. 2005; 41: 2584-2591. doi: 10.1016/j.eurpolymj.2005.05.035
39. Abdel-Bary EM, Abdel-Razik EA, Abdelaal MY, El-Sherbiny IM. Stability of polypropylene blends under the effect of thermal and UV-degradation. Polymer-Plastics Technology & Engineering, (USA). 2005; 44(5): 847-862. doi: 10.1081/PTE-200060842

Kozui Kida, MD, PhD

Professor
Department of Internal Medicine
Nippon Medical School
4-7-15 Kudan-minami, Chiyoda-ku
Tokyo 102-0074, Japan

BiographyResearch InterestScientific ActivitiesPublications

1. Hattori K, Ishii T, Motegi T, Kusunoki Y, Gemma A, Kida K. Relationship between serum cardiac troponin T level and cardiopulmonary function in stable chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis. 2015; 10(1): 309-320. doi: http://dx.doi.org/10.2147/COPD.S76293
2. Ishii T, Gemma A, Kida K. Senescence is involved in the pathogenesis ofchronic obstructive pulmonary disease through effects on telomeres and theanti-aging molecule fibroblast growth factor23. Geriatr Gerontol Int. 2014. doi: 10.1111/ggi.12354
3. Kokuho N, Ishii T, Kamio K, et al. Diagnostic Values For Club Cell Secretory Protein (CC16) inSerum of Patients of Combined Pulmonary Fibrosis and Emphysema. COPD. 2014. doi: 10.3109/15412555.2014.948994
4. Angata T, Ishii T, Gao C, et al. Association of serum interleukin-27 with the exacerbation of chronic obstructive pulmonary disease. Physiol Rep. 2014; 2(7): e12069. doi: 10.14814/phy2.12069
5. Ishii T, Motegi T, Kamio K, Gemma A, Kida K. Association of group componentgenetic variations in COPD and COPD exacerbation in a Japanese population. Respirology. 2014; 19: 590-595. doi: 10.1111/resp.12277
6. Ishii T, Kida K. Predictors of chronic obstructive pulmonary disease exacerbations. Curr Opin Pulm Med. 2014; 20: 138-145. doi: 10.1097/MCP.0000000000000031
7. Kida K, Motegi T, Ishii T, Hattori K. Long-term oxygen therapy in Japan: history, present status, and current problems. PneumonolAlergol Pol. 2013; 81: 468-478.
8. Kobayashi S, Fujinawa R, Ota F, et al. A single dose of lipopolysaccharide into mice with emphysemamimics human chronic obstructive pulmonary disease exacerbation as assessed bymicro-computed tomography. Am J Respir Cell Mol Biol. 2013; 49: 971-977. doi: 10.1165/rcmb.2013-0074OC
9. Motegi T, Jones RC, Ishii T, et al. A comparison of three multidimensional indices of COPD severity as predictors of future exacerbations. Int J Chron Obstruct Pulmon Dis. 2013; 8: 259-271. doi: 10.2147/COPD.S42769
10. Angata T, Ishii T, Motegi T, et al. Loss of Siglec-14 reduces the risk of chronic obstructive pulmonary disease exacerbation. Cell Mol Life Sci. 2013; 70: 3199-3210. doi: 10.1007/s00018-013-1311-7
11. Kamio K, Ishii T, Motegi T, et al. Decreased serum transforming growth factor-1 concentration with aging isassociated with the severity of emphysema in chronic obstructive pulmonary disease. Geriatr Gerontol Int. 2013; 13: 1069-1075. doi: 10.1111/ggi.12031
12. Motegi T, Yamada K, Ishii T, Gemma A, Kida K. Long-term management of chronicobstructive pulmonary disease: a survey of collaboration among physiciansinvolved in pulmonary rehabilitation in Japan. Respir Investig. 2012; 50: 98-103. doi: 10.1016/j.resinv.2012.06.004
13. Kamio K, Yoshida T, Gao C, et al. α1,6-Fucosyltransferase (Fut8) is implicated in vulnerability to elastase-induced emphysema in mice and a possible non-invasive predictive marker for disease progression and exacerbations in chronic obstructive pulmonarydisease (COPD). Biochem Biophys Res Commun. 2012; 424: 112-117. doi: 10.1016/j.bbrc.2012.06.081
14. Ishii T, Hagiwara K, Ikeda S, et al. Association between genetic variations in surfactantprotein d and emphysema, interstitial pneumonia, and lung cancer in a Japanesepopulation. COPD. 2012; 9: 409-416. doi: 10.3109/15412555.2012.676110
15. Yamada M, Ishii T, Ikeda S, et al. Association of fucosyltransferase 8 (FUT8) polymorphism Thr267Lys with pulmonary emphysema. J Hum Genet. 2011; 56: 857-860. doi: 10.1038/jhg.2011.118
16. Kimura K, Kurosaki H, Wakabayashi R, et al. Concerns with the health check-up system for chronic obstructive pulmonary disease on two Japanese islands. Intern Med. 2011; 50: 2135-2141.
17. Ishii T, Hagiwara K, Kamio K, et al. Involvement of surfactant protein D in emphysema revealed by genetic association study. Eur J Hum Genet. 2012; 20: 230-235. doi: 10.1038/ejhg.2011.183
18. Furutate R, Ishii T, Wakabayashi R, et al. Excessive visceral fat accumulation in advanced chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis. 2011; 6: 423-430. doi: 10.2147/COPD.S22885
19. Wakabayashi R, Motegi T, Yamada K, et al. Efficient integrated education for older patients with chronicobstructive pulmonary disease using the Lung Information Needs Questionnaire. Geriatr Gerontol Int. 2011; 11: 422-430. doi: 10.1111/j.1447-0594.2011.00696.x
20. Wakabayashi R, Motegi T, Yamada K, Ishii T, Gemma A, Kida K. Presence ofin-home caregiver and health outcomes of older adults with chronic obstructivepulmonary disease. J Am Geriatr Soc. 2011; 59: 44-49. doi: 10.1111/j.1532-5415.2010.03222.x
21. Fujimoto K, Ikeda S, Arai T, et al. Polymorphism of SERPINE2 gene is associated with pulmonary emphysema in consecutive autopsy cases. BMC Med Genet. 2010; 11: 159. doi: 10.1186/1471-2350-11-159
22. Ishii T, Wakabayashi R, Kurosaki H, Gemma A, Kida K. Association of serotonintransporter gene variation with smoking, chronic obstructive pulmonary disease, and its depressive symptoms. J Hum Genet. 2011; 56: 41-46. doi: 10.1038/jhg.2010.133
23. Motohashi N, Kimura K, Ishii T, et al. Emphysema on imaging is associated with quality of life in elderly patients with chronic obstructive pulmonary disease. Geriatr Gerontol Int. 2010; 10: 17-24. doi: 10.1111/j.1447-0594.2009.00549.x
24. Jones RC, Donaldson GC, Chavannes NH, et al. Derivation and validation of a composite index of severity in chronic obstructive pulmonary disease: the DOSE Index. Am J Respir Crit Care Med. 2009; 180: 1189-1195. doi: 10.1164/rccm.200902-0271OC
25. Kurosaki H, Ishii T, Motohashi N, et al. Extent of emphysema on HRCT affects loss of fat-free mass and fat mass in COPD. Intern Med. 2009; 48: 41-48.
26. Soma T, Hino M, Kida K, Kudoh S. A prospective and randomized study for improvement of acute asthma by non-invasive positive pressure ventilation (NPPV). Intern Med. 2008; 47: 493-501. doi: http://dx.doi.org/10.2169/internalmedicine.47.0429
27. Katsura H, Yamada K, Wakabayashi R, Kida K. Gender-associated differences in dyspnoea and health-related quality of life in patients with chronic obstructive pulmonary disease. Respirology. 2007; 12: 427-432. doi: 10.1111/j.1440-1843.2007.01075.x
28. Omata M, Wakabayashi R, Kudoh S, Kida K. Correlation between bronchodilator responsiveness and quality of life in chronic obstructive pulmonary disease. Allergol Int. 2007; 56: 15-22.
29. Kida K, Wakabayashi R, Mizuuchi T, Murata A. Screening for suspected chronic obstructive pulmonary disease with an eleven-item pre-interview questionnaire (11-Q). Intern Med. 2006; 45: 1201-1207.
30. Murata A, Kouno A, Yamamoto K, Yoshioka H, Kida K, Kudoh S. The treatment of refractory pneumothorax in diffuse panbronchiolitis by intravenous administration of coagulation factor XIII concentrate. J Nippon Med Sch. 2006; 73: 89-92.
31. Katsura H, Yamada K, Wakabayashi R, Kida K. The impact of dyspnoea and legfatigue during exercise on health-related quality of life in patients with COPD. Respirology. 2005; 10: 485-490. doi: 10.1111/j.1440-1843.2005.00729.x
32. Katsura H, Yamada K, Kida K. Both generic and disease specific health-relatedquality of life are deteriorated in patients with underweight COPD. Respir Med. 2005; 99: 624-630. doi: 10.1016/j.rmed.2004.09.017
33. Katsura H, Kanemaru A, Yamada K, Motegi T, Wakabayashi R, Kida K. Long-termeffectiveness of an inpatient pulmonary rehabilitation program for elderly COPD patients: comparison between young-elderly and old-elderly groups. Respirology. 2004; 9: 230-236. doi: 10.1111/j.1440-1843.2004.00561.x
34. Katsura H, Yamada K, Kida K. Usefulness of a linear analog scalequestionnaire to measure health-related quality of life in elderly patients with chronic obstructive pulmonary disease. J Am Geriatr Soc. 2003; 51: 1131-1135. doi: 10.1046/j.1532-5415.2003.51363.x
35. Araki T, Katsura H, Sawabe M, Kida K. A clinical study of idiopathic pulmonary fibrosis based on autopsy studies in elderly patients. Intern Med. 2003; 42: 483-489.
36. Katsura H, Kida K. A comparison of bone mineral density in elderly female patients with COPD and bronchial asthma. Chest. 2002; 122: 1949-1955. doi: 10.1378/chest.122.6.1949

Jieru Wang, MD, PhD

Assistant Professor of Pediatrics
Division of Pulmonary Medicine
Childrens Hospital of Pittsburgh of UPMC
University of Pittsburgh School of Medicine
9126 Rangos, 4401 Penn Ave
Pittsburgh, PA 15224, USA

BiographyResearch InterestScientific ActivitiesPublications

Dr. Jieru Wang received her Medical and PhD degree from Central South University in China. The outbreaks of SARS and avian influenza awakened Dr. Wangs interest in respiratory medicine, she came to the United States pursuing her post-doc training in 2003. Under the mentorship of Dr. Robert Mason, a pioneer and expert in lung alveolar type II cells, Dr. Wang has received extensive and intensive training in lung cell biology at National Jewish Health. Dr. Wang has also gained expertise in respiratory viruses including influenza A virus and coronavirus through collaboration with the well-known experts in the field including Drs. Kathryn Holmes, David Wentworth, and Kevan Hartshorn. Recently Dr. Wang has received Parker B. Francis Fellowship Award, the prestigious Fellowship Award in the area of respiratory research, NIH funding, and start-up funding from University of Pittsburgh in study of influenza A viruses.
Since July 2013, Dr. Wang has established her laboratory in the Department of Pediatrics at University of Pittsburgh School of Medicine. Her lab mainly works on the primary respiratory cells, she has established the primary culture system in isolating and culturing human and mouse alveolar type II cells and Macrophages. Using primary culture system in combination with mouse models, Dr. Wangs group is trying to address how influenza virus impairs the alveolar epithelial barrier of the lung and how epithelial cell-immune cell interactions orchestrate innate immune response to the virus. In addition, she is also interested in how genetic and epigenetic factors affect individual response to respiratory pathogens.

Her research interests include: Lung Infection, Influenza, Pulmonary Inflammation and Immunity and Aging.

MEMBERSHIPS


• Full Member The American Association of Immunologist (2014-Present)
• Full Member American Thoracic Society (2011-2014)
• Full Member The American Physiology Society (2010-2011)
• Full Member American Society for Virology (2007-2010)
• Full member Sigma XI, the Scientific Research Society (2006-2007)
• Member International society of free radical biology and medicine, SFRBM (2005-2006)

PEER-REVIEWED PAPERS


1. Li L, Hamzeh N, Gillespie M, et al. Beryllium increases the CD14dimCD16+ subset in the lung of chronic beryllium disease. PLoS One. 2015; 10(2): e0117276. doi: 10.1371/journal.pone.0117276
2. Zhou B, Pearce MB, Li Y, et al. Asparagine substitution at PB2 residue 701 enhances the replication, pathogenicity and transmission of the 2009 pandemic H1N1 influenza A virus. PLoS One. 2013; 8(6): e67616. doi: 10.1371/journal.pone.0067616
3. Zhang W, Huang C, Gong Z, et al. Expression of LINC00312, a long intergenic non-coding RNA, is negatively correlated with tumor size but positively correlated with lymph node metastasis in nasopharyngeal carcinoma. J Mol Histol. 2013; 44(5): 545-554. doi: 10.1007/s10735-013-9503-x
4. Macleod MK, David A, Jin N, et al. Influenza nucleoprotein delivered with aluminium salts protects mice from an influenza A virus that expresses an altered nucleoprotein sequence. PLoS One. 2013; 8(4): e61775. doi: 10.1371/journal.pone.0061775
5. Qian Z, Travanty EA, Oko L, et al. Innate Immune Response of Human Alveolar Type II Cells Infected with SARS-Coronavirus. Am J Respir Cell Mol Biol. 2013; 48(6): 742-748. doi: 10.1165/rcmb.2012-0339OC.
6. Wu Q, Case SR, Minor M, et al. A novel function of MUC18: amplification of lung inflammation during bacterial infection. Am J Pathol. 2013; 182(3): 819-827. doi: 10.1016/j.ajpath.2012.11.005
7. Kosmider B, Messier EM, Janssen WJ, et al. Nrf2 protects human alveolar epithelial cells against injury induced by influenza A virus. Respir Res. 2012; 13(1): 43. doi: 10.1186/1465-9921-13-43
8. Zhang W, Zeng Z, Fan S, et al. Evaluation of the prognostic value of TGF-β superfamily type I receptor and TGF-β type II receptor expression in nasopharyngeal carcinoma using high-throughput tissue microarrays. J Mol Histol. 2012. doi: 10.1007/s10735-012-9392-4
9. Wang J, Nikrad M, Travanty E, et al. Innate immune response of primary human alveolar macrophages during influenza A infection. PLoS ONE. 2012; 7(3): e29879. doi: 10.1371/journal.pone.0029879
10. Funk CJ, Wang J, Ito Y, et al. Infection of human alveolar macrophages by coronavirus 229E. J Gen Virol. 2012; 93(3): 494-503. doi: 10.1099/vir.0.038414-0
11. Watanabe T, Shinya K, Watanabe S, et al. Avian-type receptor-binding ability can increase influenza virus pathogenicity in macaques. J Virol. 2011; 85(24): 13195-13203. doi: 10.1128/JVI.00859-11
12. Yu WC, Chan RW, Wang J, et al. Viral replication and innate host responses in primary human alveolar epithelial cells and alveolar macrophages infected with influenza H5N1 and H1N1 viruses. J Virol. 2011; 85(14): 6844-6855. doi: 10.1128/JVI.02200-10
13. Macleod MK, McKee AS, David A, et al. Vaccine adjuvants aluminum and monophosphoryl lipid A provide distinct signals to generate protective cytotoxic memory CD8 T cells. Proc Natl Acad Sci USA. 2011; 108(19): 7914-7919. doi: 10.1073/pnas.1104588108
14. Wang J, Nikrad M, Phang T, et al. Innate immune response to influenza A virus in differentiated human alveolar type II cells. Am J Respir Cell Mol Biol. 2011; 45(3): 582-591. doi: 10.1165/rcmb.2010-0108OC
15. Wang J, Oberley-Deegan R, Wang S, Funk CJ, Hartshorn KL, Mason RJ. Differentiated human alveolar type II cells secrete antiviral IL-29 (IFN-lambda 1) in response to influenza a infection. J Immunol. 2009; 182(3): 1296-1304.
16. Mossel E, Wang J, Jeffers S, et al. SARS-CoV replicates in primary human alveolar type II cell cultures but not in type I-like cells. Virology. 2008; 372(1): 127-135. doi: 10.1016/j.virol.2007.09.045
17. Miura TA, Wang J, Holmes K, Mason RJ. Rat coronaviruses infect rat alveolar type I epithelial cells and induce expression of CXC chemokines. Virology. 2007; 369(2): 288-298. doi: 10.1016/j.virol.2007.07.030
18. Wang J, Edeen K, Manzer R, et al. Differentiated human alveolar epithelial cells and reversibility of their phenotype in vitro. Am J Respir Cell Mol Biol. 2007; 36(6): 661-668. doi: 10.1165/rcmb.2006-0410OC
19. Wu M, Wang J, Li G. Progression of molecular genetics in primary brain tumor. International Journal of Pathology and Clinical Medicine. 2007; 27(3): 9-226.
20. Wang J, Wang S, Manzer R, McConville G, Mason RJ. Ozone induced oxidative stress in rat alveolar epithelial cells. Free Radic Biol Med. 2006; 40(11): 1914-1928.
21. Manzer R, Wang J, Nishina K, McConville G, Mason RJ. Alveolar epithelial cells secrete chemokines in response to IL-1beta and lipopolysaccharide but not to ozone. Am J Respir Cell Mol Biol. 2006; 34(2): 158-166. doi: 10.1165/rcmb.2005-0205OC
22. Miura TA, Wang J, Mason RJ, Holmes K. Rat coronavirus infection of primary rat alveolar epithelial cells. Adv Exp Med Biol. 2006; 58: 351-356.
23. Chang YS, Wang J, Lu XJ, Thewke DP, Mason RJ. KGF induces lipogenic genes through a P13K and JNK/SREBP-1 pathway in H292 cells. J Lipid Res. 2005; 46(12): 2624-2635.
24. Nishina K, Zhang F, Nielsen L, Wang J, Mason RJ. Expression of CINC-2 beta is related to the status of differentiation of alveolar epithelial cells. Am J Respir Cell Mol Biol. 2005; 33(5): 505-512.
25. Fan SQ, Wang JR, Huang H, et al. Function of a novel brain-specific gene LRRC4. Zhonghua Zhong Liu Za Zhi. 2005; 27(7): 393-396.
26. Zhang Q, Wang J, Fang S, et al. Expression and functional characterization of LRRC4, a novel brain-specific member of the LRR superfamily. FEBS Lett. 2005; 579(17): 3674-3682. doi: http://dx.doi.org/10.1016/j.febslet.2005.05.058
27. Zhang QH, Wang LL, Peng C, et al. Establishment of brain relatively specific gene LRRC4 with doxycycline induced Tet regulating system in U251 glioma cell line. Prog Biochem Biophys. 2005; 32(4): 325-330.
28. Zhang QH, Wang LL, Cao L, et al. Study of a novel brain relatively specific gene LRRC4 involved in glioma tumorigenesis suppression using the Tet-on system. Acta Biochim Biophys Sin (Shanghai). 2005; 37(8): 532-540. doi: 10.1111/j.1745-7270.2005.00079.x
29. Zhang XM, Sheng SR, Wang XY, Bin LH, Wang JR, Li GY. Expression of tumor related gene NAG6 in gastric cancer and restriction fragment length polymorphism analysis. World J Gastroenterol. 2004; 10(9): 1361-1364.
30. Xiong W, Zeng ZY, Xia JH, et al. Susceptibility locus at chromosome 3p21 linked to familial nasopharyngeal carcinoma. Cancer Res. 2004; 64(6): 1972-1974. doi: 10.1158/0008-5472.CAN-03-3253
31. Wang JR, Li X, Fan SQ, et al. Expression of LRRC4 in the U251glioblastoma cell line correlates with the decrease rate and tumorigenic potential. Ai Zheng. 2003; 22(9): 897-902.
32. Zhang XM, Sheng SR, Wang XY, Wang JR, Jiang L. Expression of tumor related genes NGX6, NAG-7, BRD7 in gastric and colorectal cancer. World J Gastroenterol. 2003; 9(8): 1729-1733.
33. Fan SQ, Zhou M, Xiang Q, et al. In situ expression of connexins in various carcinomas. Ai Zheng. 2003; 22(6): 686-690.
34. Wang JR, Dong L, Tan C, Li XL, Li GY. Molecular cloning and sequence character of a glial-specific gene, LRRC4, downregulated in brain tumors. Chinese Cancer Research Progress. 2002; 29(6): 426-433.
35. Zeng ZY, Xiong W, Li XL, Wang JR, Li GY. Establishment of literature database of nasopharyngeal carcinoma (NPC) related gene. Chinese Journal of Cancer. 2002, 21(9): 1026-1028.
36. Wang JR, Dong L, Li GY. Preliminary Study of LRRC4 Protein: Bioinformatics Analysis, Fusion Expression and Localization. Prog.Biochem. Biophys. 2002; 29(5): 696-701.
37. Tan C, Li J, Wang J, et al. Proteomic analysis of differential protein expression in human nasopharyngeal carcinoma cells induced by NAG7-transfection. Proteomics. 2002, 2(2): 306-312. doi: 10.1002/1615-9861(200203)2:3<306::AID-PROT306>3.0.CO;2-#
38. Qian J, Zhang XM, Li XL, et al. Identification of digital differential expression patterns of a novel human gene (UBAP1) by an expressed sequence tag strategy. Ai Zheng. 2002; 21(3): 225-228.
39. Wang JR, Qian J, Dong L, et al. Identification of LRRC4, a novel member of leucine-rich repeat (LRR) super family, and its expression analysis in brain tumor. Prog. Biochem. Biophys. 2002; 29(2): 233-239.
40. Xiang JJ, Yu Y, Wang JR, Li GY. Identification and characterization of a nasopharyngeal carcinoma (NPC) related gene, which shows the hallmark characteristics of a processed pseudogene. Prog. Biochem Biophys. 2002; 29(1): 51-55.
41. Qian J, Yang J, Zhang X, Zhang B, Wang J, Li GY. Isolation and characterization of a novel cDNA , UBAP1, derived from the tumor suppressor locus in human chromosome. J Cancer Res Clin Oncol. 2001; 127(10): 613-618.
42. Li J, Tan C, Xiang Q, et al. Proteomic detection of changes in protein synthesis induced by NGX6 transfection in human nasopharyngeal carcinoma cells. J Pro Chem. 2001; 20(3): 265-271.
43. Tan C, Li J, Wang JR, Li GY. Identification and significance of down-regulated proteins in HNE1 cells transfected with NAG7. Chin J Biochem Mol Biol. 2001; 17(6): 688-693.
44. Wang JR, Bin LH, Qian J, Zhang XH, Li GY. Preliminary study of a novel gene negatively associated with nasopharyngeal carcinoma on chromosome 7q31-32. Chin J Cancer. 2001; 20(7): 688-691.
45. Li J, Tan C, Xiang Q, et al. Preliminary function study of a putative tumor suppressor gene in human nasopharyngeal carcinoma cells using two-dimensional electrophoresis and mass spectrometry. Chinese Journal of Cancer. 2001, 20(7): 692-695.
46. Qian J, Zhang XH, Yang JB, et al. Cloning and expression analysis of a novel gene, UBAP1, possibly involved in ubiquitin pathway. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai). 2001; 33(2): 147-152.
47. Zhang XH, Qian J, Wang JR, Bin L, Li GY. Cloning of a novel putative tumor suppressor gene associated with nasopharyngeal carcinoma on the smallest common deletion region of 7q32-ter. Chin J Cancer. 2000; 19(11): 961-965.
48. Tan C, Li J, Xie Y, et al. Preliminary function study of NAG7 using two dimensional electrophoresis and mass spectrometry. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai). 2001; 33(4): 373-378.
49. Wang JR, Zhou J, Tan HZ. An epidemiological investigation on behavioral problem among school children in flood district. Chinese Journal of Disease Control and Prevention. 1999; 3(4): 268-270.
50. Tan HZ, Liu AZ, Wang JR, Li SQ. A multiple variable analysis about the risk factors of breast cancer in women. Bull of Hunan Med Univ. 1998; 23(4): 365-368.
51. Yang TB, Xiao XL, Wang JR, Tan HZ. A comparative study on the risk factors for the incidence of tongue cancer. Bull of Hunan Med Univ. 1998; 23(2): 141-142.
52. Liu AZ, Tan HZ, Wang JR, Li SQ. Case control study on 153 paired patients with colon cancer. Chinese Journal of Public Health. 1997; 13(3): 242-244.


BOOK CHAPTER


1. Wang JR. Statistical Consideration for Analysis of Nosocomial Infection Data. Nosocomial Infection. Hunan Science and Technology Press, Changsha. 1998; 172-190.

Masahiro Kohzuki, MD, PhD

Associate Dean
Professor and Chairman
Department of Internal Medicine and Rehabilitation Science, Disability Sciences
Tohoku University Graduate School of Medicine
Chairman of the Center of Rehabilitation Medicine
Tohoku University Hospital
Japan

BiographyResearch InterestScientific ActivitiesPublications

Prof. Masahiro Kohzuki is the Associate Dean of Tohoku University Graduate School of Medicine and the Director of Rehabilitation Center at Tohoku University Hospital, and Chairman and Professor of Internal Medicine & Rehabilitation Science in Tohoku University Graduate School of Medicine.
He is the first physiatrist who succeeded in pulmonary rehabilitation to the lung transplant patient from a brain-dead donor in Japan. He and Dr. Kurosawa published an article of Visualization of airflow limitation in emphysematous lung. in New England Journal of Medicine (N Eng J Med 350: 1036, 2004).
He is a Chairman of the Board of Directors of Japanese Society of Renal Rehabilitation and one of the Directors of several association including Japanese Association of Rehabilitation Medicine and Japanese Association of Cardiac Rehabilitation.
He was a President of Directors of Rehabilitation Centers at National University Hospitals in Japan.
He is the Editor-in-Chief of Open Journal of Therapy and Rehabilitation and Editorial Board of several international journals.
He is the visiting professor of Tianjin Medical Univerisity (China), Northeast Normal University (China), Woosong University (Korea), Masaryk University (Czech).

His research interests include: Pulmonary rehabilitation.

AWARDS AND HONORS


• (2003) Encouragement Award, Japanese Association of Rehabilitation Medicine
• (2004) Best Paper Award, Japanese Association of Rehabilitation Medicine
• (2007) President Award, Japanese Society of Stoma and Continence Rehabilitation
• (2007, 2010) Award of the Head of Tohoku University Hospital


MEMBERSHIPS IN INTERNATIONAL PROFESSIONAL SOCIETIES


• International Society of Physical and Rehabilitation Medicine
• Asia-Oceania Society of Physical and Rehabilitation Medicine
• American Society of Physical Medicine and Rehabilitation
• International Society of Hypertension
• American College of Sports Medicine
• American Heart Association

1. Yasujima M, Abe K, Kohzuki M, et al. Atrial natriuretic factor inhibits the hypertension induced by chronic infusion of norepinephrine in conscious rats. Circ Res. 1985; 57: 470-474. doi: 10.1161/01.RES.57.3.470
2. Kohzuki M, Abe K, Yasujima M, et al. Chronic effect of a synthetic atrial natriuretic factor on the development of hypertension in young spontaneously hypertensive rats. J Hypertens. 1986; 4 (Suppl 3): 487-489.
3. Kasai Y, Abe K, Yasujima M, et al. The augmented hypotensive response to a synthetic atrial natriuretic factor in SHR. J Hypertens. 1986; 4(suppl 3): 325-327.
4. Sato M, Abe K, Takeuchi K, et al. Atrial natriuretic factor and cyclic guanosine monophosphate in vascular smooth muscle. Hypertension. 1986; 8: 762-771. doi: 10.1161/01.HYP.8.9.762
5. Sato M, Abe K, Takeuchi K, et al. Atrial natriuretic polypeptide and cyclic GMP synthesis in vascular smooth muscle, glomerular mesangial and renal collecting tubule cell in culture. J Hypertens. 1986; 4(Suppl 6): 576-587.
6. Tanno M, Abe K, Yasujima M, et al. The prostaglandin (PG)-thromboxane (TX) system in the development of hypertension in young SHR. J Hypertens. 1986; 4(Suppl 3): 395-397.
7. Tsunoda K, Abe K, Omata K, et al. Hypotensive and natriuretic effects of nifedipine in essential hypertension: Role of renal kallikrein-kinin-prostaglandin and renin-angiotensin-aldosterone systems. J Clin Hypertens. 1986; 2: 263-270.
8. Yasujima M, Abe K, Tanno M, et al. Effects of ouabain on blood pressure regulation in rats. J Hypertens. 1986; 4: 597-601.
9. Yasujima M, Abe K, Kohzuki M, et al. Effect of atrial natriuretic factor on angiotensin II-induced hypertension in rats. Hypertension. 1986; 8: 748-753. doi: 10.1161/01.HYP.8.9.748
10. Yasujima M, Abe K, Tanno M, et al. Effects of sodium and angiotensin II on urinary active and inactive kallikrein in rats. J Hypertens. 1986; 4: 13-18.
11. Yasujima M, Abe K, Kohzuki M, et al. Antihypertensive effect of synthetic atrial natriuretic factor in vasopressin-infused rats. Jap Circ J. 1986; 50: 1185-1190. doi: http://dx.doi.org/10.1253/jcj.50.1185
12. Yasujima M, Abe K, Kohzuki M, et al. Chronic effect of synthetic atrial natriuretic factor in rats made hypertensive by sustained infusion of vasopressin. Biologically Active Atrial Peptides. 1987; 1: 519-523.
13. Kasai Y, Abe K, Yasujima M, Tanno M, Kohzuki M, Yoshinaga K. Acute effects of synthetic atrial natriuretic factor in anesthetized spontaneously hypertensive rats and DOCA-salt hypertensive rats. Biologically Active Atrial Peptides. American Society of hypertension Symposium Series. 1987; 1: 376-379.
14. Sato M, Abe K, Takeuchi K, et al. Inhibitory effect of sulindac on prostaglandin synthesis in cultured renal and vascular cells. Agents and Actions. 1987; 22: 370-378.
15. Yasujima M, Abe K, Tanno M, et al. Long-term effects of aldosterone on kallikrein, prostaglandin E2 and sodium in rats. Tohoku J Exp Med. 1987; 152: 351-362. doi: http://dx.doi.org/10.1620/tjem.152.351
16. Yasujima M, Abe K, Tanno M, et al. Role of the prostaglandin-thromboxane system in the development and maintenance of spontaneously hypertension in the rats. Agents and Actions. 1987; 22(Suppl 1): 133-138.
17. Yasujima M, Abe K, Tanno M, et al. No evidence on significant roles of the prostaglandin thromboxane and kallikrein-kinin system in the antihypertensive effect of MK421 in rats made hypertensive by norepinephrine or vasopressin. Clin Exp Hypertens. 1987; A9: 323-328.
18. Kohzuki M, Abe K, Yasujima M, et al. A case of systemic lupus erythematosus complicated with vascular occlusion in the aorta and renal artery. Jap J Med. 1987; 76: 713-714.
19. Yasujima M, Abe K, Tanno M, et al. Renal kallikrein activity in spontaneously hypertensive rats. J Hypertens. 1987; 5: 687-692.
20. Yasujima M, Abe K, Tanno M, et al. Effects of angiotensin converting enzyme inhibitors MK421, SA446 and captopril on renal prostaglandin E and kinins in conscious normotensive rats. Clin Exp Hypertens. 1987; A9: 401-404.
21. Kohzuki M, Hodsman GP, Harrison RW, Johnston CI. Attenuated renal response to atrial natriuretic peptide infusion in rats with heart failure. Clin Exp Pharmacol Physiol. 1988; 15: 323-326.
22. Hodsman GP, Kohzuki M, Howes LG, Sumithran E, Tsunoda K, Johnston CI. Neurohumoral responses to chronic myocardial infarction in rats. Circulation. 1988; 78: 376-381. doi: 10.1161/01.CIR.78.2.376
23. Johnston CI, Mendelsohn FAO, Cubela R, Jackson B, Kohzuki M, Fabris B. Inhibition of angiotensin converting enzyme (ACE) in plasma and tissues: studies ex vivo after administration of ACE inhibitors. J Hypertens. 1988; 6(Suppl 3): 17-22.
24. Johnston CI, Jackson B, Hodsman GP, Phillips P, Kohzuki M. Hypertension and renal function. J Nephrology (ROC). 1988; 151-153.
25. Kudo k, Abe K, Chiba S, et al. Role of thromboxane A2 in the hypotensive effect of captopril in essential hypertension. Hypertension. 1988; 11: 147-152. doi: 10.1161/01.HYP.11.2.147
26. Sato K, Abe K, Seino M, et al. Renal vein plasma renin activity in patients with unilateral renovascular hypertension. Jpn Circ J. 1988; 52: 431-436.
27. Yasujima M, Abe K, Kohzuki M, et al. Chronic effects of synthetic atrial natriuretic factor in mineralocorticoid hypertension in rats. Advance in Atrial Peptide Research. 1988; 2: 530-533.
28. Yasujima M, Abe K, Kanazawa M, et al. Effects of chronically administered atrial natriuretic factor in aldosterone-infused hypertensive rats. Jpn Circ J. 1988; 52: 1446-1449.
29. Johnston CI, Jackson B, Cubela R, Sivell D, Kohzuki M. Pharmacokinetics of angiotensin converting enzyme inhibitors in plasma and tissue using radio-inhibitor binding and displacement assays. Adv Exp Med Biol. 1989; 247: 29-34. doi: 10.1007/978-1-4615-9543-4_5
30. Johnston CI, Kohzuki M. Angiotensin converting enzyme: localization, regulation and inhibition. in Current Advances in Angiotensin Converting Enzyme Inhibitor. In: Sever P, MacGregor G, eds. Churchill-Livingstone, London. 1989; 3-7.
31. Johnston CI, Kohzuki M, Phillips P, Hodsman GP. Drug effects and atrial natriuretic peptide in experimental cardiac failure. Advances in Atrial Peptide Research. 1989; 3: 121-129.
32. Kohzuki M, Hodsman GP, Johnston CI. Attenuated response to atrial natriuretic peptide in rats with myocardial infarction. Am J Physiol. 1989; 256: H533-H538.
33. Kohzuki M, Hodsman GP, Harrison RW, Patrick W, Johnston CI. Attenuated renal and hypotensive responses to atrial natriuretic peptide infusion and changes in cyclic GMP in rats with heart failure. J Cardiovasc Pharmacol. 1989; 13 (Suppl 6): 43-46.
34. Kanazawa M, Abe K, Yasujima M, et al. Role of renal kallikrein in the regulation of blood pressure in the rat remnant kidney model of chronic renal failure. In: Kinins V, (Part B), Abe K, Moriya H, Fujii S, eds. Plenum Publishing Corporation, New York. 1989; 121-125.
35. Johnston CI, Hodsman PG, Kohzuki M, Casley DJ, Fabris B, Phillips PA. Interaction between atrial natriuretic peptide (ANP) and the renin-angiotensin system: endogenous antagonists. Am J Med. 1989; 87: 24-28.
36. Kanazawa M, Abe K, Yasujima M, et al. Role of renal kallikrein in the increased fractional sodium excretion in the rat remnant kidney model of chronic renal remnant kidney model of chronic renal failure. In: Kinins V, (Part B), Abe K, Moriya H, Fujii S, eds. Plenum Publishing Corporation, New York. 1989; 449-454.
37. Kohzuki M, Chai SY, Casley DJ, Rogerson F, Johnston CI, Mendelsohn FAO. Endothelin receptors in rat adrenal gland visualized by quantitative autoradiography. Clin Exp Pharmacol Physiol. 1989; 16: 239-242.
38. Kohzuki M, Johnston CI, Chai SY, Casley DJ, Mendelsohn FAO. Localization of endothelin receptors in rat kidney. Eur J Pharmacol. 1989; 160: 193-194.
39. Yasujima M, Abe K, Kanazawa M, et al. Effects of antihypertensive drugs on renal function and atrial natriuretic polypeptide in spontaneously hypertensive rats with renal ablation. Tohoku J Exp Med. 1989; 158: 85-94. doi: http://dx.doi.org/10.1620/tjem.158.85
40. Chai SY, Sakaguchi K, Kohzuki M, Jackson B, Johnston CI, Mendelsohn FAO. Inhibition of ACE by using autoradiography. In: Sever P, MacGregor G, eds. In Current Advances in Angiotensin Converting Enzyme Inhibitor. Churchill-Livingstone, London. 1989; 199-202.
41. Howes LG, Hodsman GP, Maccarrone C, Kohzuki M, Johnston CI. Cardiac 3,4-dihydroxyphenylethylene glycol (DHPG) and catecholamine levels in a rat model of left ventricular failure. J Cardiovasc Pharmacol. 1989; 13: 348-352.
42. Kohzuki M, Abe K, Yasujima M, et al. Acute and chronic effects of synthetic rat atrial natriuretic factor on blood pressure and sodium excretion in spontaneously hypertensive rats. Tohoku J Exp Med. 1989; 157: 279-288.
43. Kohzuki M, Abe K, Yasujima M, et al. Blood pressure and renal response to synthetic rat atrial natriuretic factor in deoxycorticosterone acetate-salt hypertension. Tohoku J Exp Med. 1989; 157: 301-311. doi: http://dx.doi.org/10.1620/tjem.157.301
44. Fabris B, Jackson B, Kohzuki M, Perich R, Johnston CI. Increased cardiac angiotensin-converting enzyme in rats with chronic heart failure. Clin Exp Pharmacol Physiol. 1990; 17: 309-314.
45. Yasujima M, Abe K, Kanazawa M, et al. Chronic effects of synthetic endothelin on blood pressure and sodium excretion in rats. Am J Hypertens. 1990; 3: 635-637. doi: 10.1093/ajh/3.8.635
46. Yasujima M, Abe K, Tanno M, et al. Effects of digoxin on blood pressure responses to norepinephrine, angiotensin II and vasopressin in conscious rats. Tohoku J Exp Med. 1990; 162: 203-212. doi: http://dx.doi.org/10.1620/tjem.162.203
47. Yasujima M, Abe K, Kanazawa M, et al. Calcium channel blockers reverse the sustained elevation of blood pressure induced by chronic infusion of endothelin in consciuos rats. Tohoku J Exp Med. 1990; 160: 157-165. doi: http://dx.doi.org/10.1620/tjem.160.157
48. Yasujima M, Abe K, Kanazawa M, et al. Atrial natriuretic polypeptide and blood pressure regulation in rats with reduced renal mass. In: Atrial and Brain Natriuretic Peptides. In: Imura H, Matuo H, eds. Kodansha scientific Ltd, Tokyo. 1990; 391-399.
49. Kohzuki M, Johnston CI, Chai SY, Casley DJ, Mendelsohn FAO. In vitro autoradiographic endothelin S6B binding sites in rat tissues. Clin Exp Pharmacol Physiol. 1991; 18: 509-515.
50. Kohzuki M, Chai SY, Jackson B, et al. Angiotensin converting enzyme induction and inhibition in tissues: A new approach using quantitative in vitro autoradiography. J Hypertens. 1991; 9: 579-589.
51. Yasujima M, Abe K, Kanazawa M, et al. Antihypertensive effect of captopril and enalapril in endothelin-infused rats. Tohoku J Exp Med. 1991; 163: 219-227. doi: http://dx.doi.org/10.1620/tjem.163.219
52. Yoshida K, Yasujima M, Kohzuki M, et al. Chronic synergistic effect of endothelin-1 and angiotensin II on blood pressure in conscious rats. J Cardiovasc Pharmacol. 1991; 17(Suppl 7): 514-516.
53. Kohzuki M, Chai SY, Paxinos G, Karavas A, Casley D, Johnston CI. Localization and characterization of endothelin receptor binding sites in rat brain visualized by in vitro autoradiography. Neuroscience. 1991; 42: 250-260. doi: 10.1016/0306-4522(91)90162-H
54. Kohzuki M, Chen BZ, Mooser V, Jandeleit K, Johnston CI. Angiotensin converting enzyme in the spontaneously hypertensive rat. Genetic Hypertension. 1992; 218: 503-505.
55. Kohzuki M, Yasujima M, Yoshida K, Kanazawa M, Yoshinaga K, Abe K. The kidney protecting effect of trandolapril in normotensive and hypertensive rats. Pharmacometrics. 1992; 44: 309-315.
56. Yoshida K, Yasujima M, Kohzuki M, Kanazawa M, Abe K, Yoshinaga K. Endothelin-1 augments presser response to angiotensin II infusion infusion in rats. Hypertension. 1992; 20: 292-297. doi: 10.1161/01.HYP.20.3.292
57. Yasujima M, Kanazawa M, Yoshida K, et al. Chronic treatment with anti-endothelin antibodies fails to modify the development of hypertension in stroke-prone spontaneously hypertensive rats. Tohoku J Exp Med. 1993; 169: 43-50. doi: http://dx.doi.org/10.1620/tjem.169.43
58. Yasujima M, Yoshida K, Kanazawa M, et al. Urinary active kallikrein excretion and diabetic renal impairments in streptozotocin-treated rats. Tohoku J Exp Med. 1993; 171: 135-144. doi: http://dx.doi.org/10.1620/tjem.171.135
59. Yasujima M, Kanazawa M, Yoshida K, et al. The augmented blood pressure response to chronic angiotensin II infusion in partially nephrectomized rats. Tohoku J Exp Med. 1993; 169: 271-277. doi: http://dx.doi.org/10.1620/tjem.169.271
60. Kohzuki M, Yasujima M, Kanazawa M, et al. Angiotensin converting enzyme inhibitors and progression of chronic renal mass. Inhibition of the Renin-Angiotensin System; Recent Advances. In: Sever P, MacGregor G, eds. Gardiner-Caldwell communications Ltd, Hong-Kong. 1994; 63-68.
61. Kohzuki M, Yasujima M, Yoshida K, Kanazawa M, Abe K. Antihypertensive and antiproteinuretic effects of losartan in spontaneously hypertensive rats with chronic renal failure. Hypertens Res. 1994; 17: 173-178.
62. Kohzuki M. The role of renin-angiotensin system on myocardial hypertrophy in rats with chronic myocardial infarction. Annual Report of the Cardiovascular Research Foundation. 1994; 4: 38-41.
63. Yoshida K, Yasujima M, Kohzuki M, Kanazawa M, Abe K. The effects of chronic treatment of calcium channel blockers and angiotensin converting enzyme inhibitors on renal function in the streptozotocin diabetic rats. Hypertens Res. 1994; 17: 35-41.
64. Kohzuki M, Yasujima M, Kanazawa M, et al. Antihypertensive and renal-protective effects of losartan in streptozotocin diabetic rats. J Hypertens. 1995; 13: 97-103.
65. Kohzuki M, Yasujima M, Kanazawa M, Yoshida K, Abe K. Do kinins mediate cardioprotective and renoprotective effects of cilazapril in spontaneously hypertensive rats (SHRs) with renal ablation ? Clin Exp Pharmacol Physiol. 1995; 22(Suppl 1): 357-359.
66. Kohzuki M, Yasujima M, Liu PF, et al. Cardiovascular and renal protective effects of losartan in spontaneously hypertensive rats with diabetes mellitus. Clin Exp Pharmacol Physiol. 1995; 22 (Suppl 1): 366-367.
67. Kohzuki M, Yasujima M, Kanazawa M, Yoshida K, Sato T, Abe K. Effects of recombinant human erythropoietin (EPO) on blood pressure and renal function in SHRs with chronic renal failure. Clin Exp Pharmacol Physiol. 1995; 22 (Suppl 1): 165-166.
68. Kohzuki M, Kanazawa M, Liu PF, et al. Kinin and angiotensin II receptor antagonists in rats with chronic renal failure: the chronic effects on cardio- and reno-protection of angiotensin converting enzyme inhibitors. J Hypertens. 1995; 13: 1785-1790.
69. Kohzuki M, Onodera H, Yasujima M, et al. Endothelin receptors in ischemic rat brain and Alzheimer brain. J Cardiovasc Pharmacol. 1995; 26(Suppl 3): 329-331.
70. Yoshida K, Kohzuki M, Yasujima M, Kanazawa M, Abe K. Effects of benidipine, a calcium antagonist, on urinary kallikrein excretion and renal impairment in experimental diabetes. J Hypertens. 1996; 14: 215-222.
71. Kohzuki M, Kanazawa M, Yoshida K, et al. Cardiac angiotensin converting enzyme and endothelin receptor in rats with chronic myocardial infarction. J pn Circ J. 1996; 60: 972-980. doi: http://dx.doi.org/10.1253/jcj.60.972
72. Jiang Z-L, Harada T, Kohzuki M, Kamimoto M, Sato T. Serum enzymatic changes in insulin-induced hypoglycaemia in experimental rabbits. Tohoku J Exp Med. 1996; 179: 219-222.
73. Kohzuki M, Kanazawa M, Yoshida K, et al. Cardiomegaly and vasoactive hormones in rats with chronic myocardial infarction: long-term effects of chlorothiazide. Clin Sci. 1996; 90: 31-36.
74. Kohzuki M, Yoshida K, Kamimoto M, Wu X-M, Hashimoto M, Sato T. Disability prevention of chronic heart failure (CHF): Introduction of an animal heart failure model to the study of rehabilitation medicine. In: Ueda S, Nakamura R, Ishigami S, eds. Proceedings of the 8th World Congress of the International Rehabilitation Medicine Association (IRMA VIII). 1997; 1001-1004.
75. Kohzuki M, Kamimoto M, Wu X-M, et al. Disability prevention of chronic renal failure (CRF): Introduction of an animal renal failure model to the study of rehabilitation medicine. In: Ueda S, Nakamura R, Ishigami S, eds. Proceedings of the 8th World Congress of the International Rehabilitation Medicine Association (IRMA VIII). 1997; 1033-1036.
76. Keitoku M, Kohzuki M, Kato H, et al. FMLP actions and its binding sites in isolated human coronary arteries. J Mol Cell Cardiol. 1997; 29: 881-894. doi: http://dx.doi.org/10.1006/jmcc.1996.0291
77. Kohzuki M, Kamimoto M, Wu X-M, Yoshida K, Watanabe M, Sato T. Disability prevention of chronic renal failure (CRF): Effects of mild to moderate exercise in rats with CRF. In: Ueda S, Nakamura R, Ishigami S, eds. Proceedings of the 8th World Congress of the International Rehabilitation Medicine Association (IRMA VIII). 1997; 1037-1040.
78. Yoshida K, Kohzuki M, Casley DJ, Johnston CI. Angiotensin-converting enzyme inhibition and salt in experimental myocardial infarction. J Cardiovasc Pharmacol. 1998; 32: 357-365.
79. Kohzuki M, Kamimoto M, Wu X-M, Yoshida K, Sato T. Chronic effects of FR139317 and enalapril on renal failure rats with moderate exercise. J Cardiovasc Pharmacol. 1998; 31(Suppl 1): 486-488.
80. Kohzuki M, Tanda S, Hori K, et al. Endothelin receptors and angiotensin II receptors in tumor tissue. J Cardiovasc Pharmacol. 1998; 31(Suppl 1): 531-533.
81. Jiang Z-L, Harada T, Yokokawa M, Kohzuki M, Sato T. Muscle damage induced by experimental hypoglycemia. Metabolism. 1998; 47: 1472-1476.
82. Kuge N, Kohzuki M, Sato T. Relation between natriuresis and urinary excretion of hydrogen peroxide. Free Rad Res. 1999; 30: 119-123.
83. Kohzuki M, Wu X-M, Kamimoto M, et al. Renal-protective effect of non-depressor dose of cicletanine in streptozotocin diabetic rats. J Hypertens. 1999; 17: 695-700.
84. Yoshida T, Kohzuki M, Yoshida K, et al. Physical and Psychological Improvements after Phase II Cardiac Rehabilitation in Patients with Myocardial Infarction. Nursing and Health Sciences. 1999; 1: 163-170. doi: 10.1046/j.1442-2018.1999.00021.x
85. Kohzuki M, Tanda S, Hori K, Suzuki M, Yoshida K, Sato T. Decreased binding sites of angiotensin II in rat LY-80 and AH109A tumor and human gastric cancer using quantitative in vitro autoradiography. International Angiology. 2000; 19: 52-58.
86. Kohzuki M, Wu X-M, Kamimoto M, et al. Renal-protective effect of non-depressor dose of cicletanine in diabetic spontaneously hypertensive rats. Am J Hypertens. 2000; 13: 298-306. doi: 10.1016/S0895-7061(99)00189-2
87. Yoshida K, Arakawa M, Ishida S, Kohzuki M, Sato T, Sasaki Y. A case of lobenzarit disodium-induced hyperkalemia successfully treated with fludrocortisone acetate. Clin Exp Nephrol. 2000; 4: 67-70.
88. Kohzuki M, Abo T, Watanabe M, et al. Rehabilitating patients with hepatopulmonary syndrome using living-related orthotopic liver transplant: A case report. Archives Physical Med & Rebabilitation. 2000; 81: 1527-1530. doi: http://dx.doi.org/10.1053/apmr.2000.9393
89. Yoshida T, Yoshida K, Yamamoto C, et al. Effects of two-week hospitalized phase II cardiac rehabilitation program on physical capacity, lipid profiles and psychological variables in patients with myocardial infarction. Jpn Circ J. 2001; 65: 87-93. doi: http://dx.doi.org/10.1253/jcj.65.87
90. Yoshida K, Kohzuki M, Wu X-M, Xu X-L, Sato T. Renoprotective effects of troglitazone in spontaneously hypertensive rats with chronic renal failure. J Hypertens. 2001; 19: 503-510.
91. Watanabe M, Kohzuki M, Meguro K, Goto Y, Sato T. Marked Improvement of Neuropsychological Impairment in a Patient with Chronic Obstructive Pulmonary Disease after Lung Volume Reduction Surgery. Tohoku Journal of Experiment Medicine. 2001; 193: 67-72. doi: http://dx.doi.org/10.1620/tjem.193.67
92. Takahashi C, Kagaya Y, Namiuchi S, et al. Non selective ET receptor antagonist initiated soon after the onset of myocardial infarction may deteriorate 24-hour survival. J Cardiovasc Pharmacol. 2001; 38: 29-38.
93. Goto Y, Kohzuki M, Watanabe M, Mori N, Kurosawa H. Improved activities of daily living (ADL) and quatity of life (QOL) following lung volume reduction surgery (LVRS) for emphysema. Proceedings of the 1st World Congress of the International Society of Physical and Rehabilitation Medicine, Monduzzi Editore, Bologna. 2001; 837-840.
94. Kohzuki M, Yokogawa M, Goto Y, et al. Heart disease and hyperinsulinemia in Japanese stroke patients. Proceedings of the 1st World Congress of the International Society of Physical and Rehabilitation Medicine, Monduzzi Editore, Bologna. 2001; 531-535.
95. Saiki S, Sato T, Kohzuki M, Kamimoto M, Yoshida T. Changes in serum hypoxanthine levels by exercise in obese subjects. Metabolism. 2001; 50: 627-630. doi: http://dx.doi.org/10.1053/meta.2001.24197
96. Kohzuki M, Kamimoto M, Wu X-M, et al. Renal-protective effects of chronic exercise and antihypertensive therapy in hypertensive rats with renal failure. J Hypertens. 2001; 19: 1877-1882.
97. Kanazawa M, Kohzuki M, Yoshida K, et al. Combination therapy with an angiotensin-converting enzyme(ACE)inhibitor and a calcium antagonist: beyond the renoprotective effects of ACE inhibitor monotherapy in a spontaneous hypertensive rat with renal ablation. Hypertens Res. 2002; 25: 447-453. doi: http://dx.doi.org/10.1291/hypres.25.447
98. Chida K, Tanaka T, Saito H, et al. Ventriculography using ECG-gated multiple diastolic injection of contrast material in pediatric angiocardiography. Pediatr Cardiol. 2002; 23: 200-204. doi: 10.1007/s00246-001-0047-6
99. Minami N, Mori N, Nagasaka M, Kurosawa H, Kanazawa M, Kohzuki M. Effect of estrogen on pressor responses to α1-Adrenoreceptor agonist in conscious female rats. Hypertens Res. 2002; 25: 609-613.
100. Kawamura T, Yoshida K, Sugawara A, et al. Impact of exercise and ACE inhibition on TNF-α and leptin in hypertensive rats. Hypertens Res. 2002; 25: 919-926. doi: http://dx.doi.org/10.1291/hypres.25.919
101. Yoshida K, Xu X-L, Kawamura T, Ji L, Kohzuki M. Chronic angiotensin-converting enzyme inhibition and angiotensin II antagonism in rats with chronic renal failure. J Cardiovasc Pharmacol. 2002; 40: 533-542.
102. Chida K, Saito H, Takai Y, et al. Stability of electron-beam energy monitor for quality assurance of the electron-beam energy from radiotherapy accelerators. Tohoku J Exp Med. 2002; 198: 197-201. doi: http://dx.doi.org/10.1620/tjem.198.197
103. Kawamura T, Yoshida K, Sugawara A, et al. Regulation of skeletal muscle peroxisome proliferator-activated receptor γ expression by angiotensin-converting enzyme inhibition in fructose-fed hypertensive rats. Hypertens Res. 2003; 25: 919-926.
104. Ishizuka T, Ito O, Tan L, et al. Regulatoin of P-450 4A activity by peroxisome proliferator-activated receptors in the rat kidney. Hypertens Res. 2003; 26: 929-936. doi: http://dx.doi.org/10.1291/hypres.26.929
105. Kanazawa M, Li L, Matsumoto K, et al. Disability prevention of chronic renal failure (CRF): effects of moderate to intense exercise in rats with CRF. Proceedings of the 2nd World Congress of the International Society of Physical and Rehabilitation Medicine, Monduzzi Editore, Bologna. 2003; 517-520.
106. Minami N, Yoshikawa T, Kataoka H, et al. Effects of exercise and β-blocker on blood pressure and baroreflexes in spontaneously yypertensive rats. Am J Hypertens. 2003; 16: 966-972. doi: 10.1016/S0895-7061(03)01010-0
107. Yoshida K, Kawamura T, XU HL, Ji L, Mori N, Kohzuki M. Effects of exercise training on glomerular structure in fructose-fed spontaneously hypertensive rats. Hypertens Res. 2003; 26: 907-914. doi: http://dx.doi.org/10.1291/hypres.26.907
108. Kohzuki M, Wu X-M, Sato T, et al. Disability prevention of renal failure: effects of exercise and enalapril in Thy-1 nephritis rats. Proceedings of the 2nd World Congress of the International Society of Physical and Rehabilitation Medicine, Monduzzi Editore, Bologna. 2003; 521-524.
109. Ji L, Kohzuki M, Yoshida K, et al. Disability prevention of renal failure: effects of exercise of exercise and enalapril in nephrotic rats. Proceedings of the 2nd World Congress of the International Society of Physical and Rehabilitation Medicine, Monduzzi Editore, Bologna. 2003; 525-528.
110. Sasaki Y, Mue S, Kasai Y, et al. Gender and age differences in cardiovascular responses to 5 minutes walking exercise. Proceedings of the 2nd World Congress of the International Society of Physical and Rehabilitation Medicine, Monduzzi Editore, Bologna. 2003; 481-484.
111. Kataoka H, Kumagai E, Takahashi M, et al. Generic & disease-specific quality of life, anxiety and depression in Japanese. Proceedings of the 2nd World Congress of the International Society of Physical and Rehabilitation Medicine, Monduzzi Editore, Bologna. 2003; 643-646.
112. Mori N, Kurosawa H, Ito A, et al. Altered ventilatory patterns and efficiency in patients with severe cerebral palsy with spinal rotation, scoliosis, and mental retardation. Proceedings of the 2nd World Congress of the International Society of Physical and Rehabilitation Medicine, Monduzzi Editore, Bologna. 2003; 461-464.
113. Matsumoto K, Kurosawa H, Goto Y, et al. Reduced lung volume after chest physiotherapy. Proceedings of the 2nd World Congress of the International Society of Physical and Rehabilitation Medicine, Monduzzi Editore, Bologna. 2003; 485-488.
114. Kawamura T, Kanazawa M, Li L, et al. Peripheral adaptation to 12-week exercise training in rats with renal failure. Proceedings of the 2nd World Congress of the International Society of Physical and Rehabilitation Medicine, Monduzzi Editore, Bologna. 2003; 529-531.
115. Nagasaka M, Kohzuki M, Fujii T, et al. Low-voltage electrical stimulation induced angiogenic growth factors in hindlimb ischemia model of rats. Proceedings of the 2nd World Congress of the International Society of Physical and Rehabilitation Medicine, Monduzzi Editore, Bologna. 2003; 767-771.
116. Goto Y, Kurosawa H, Mori N, Matsumoto K, Kohzuki M. Long-term effects of lung volume reduction in exercise capacity, activities of daily living (ADL) and quality of life. Proceedings of the 2nd World Congress of the International Society of Physical and Rehabilitation Medicine, Monduzzi Editore, Bologna. 2003; 493-495.
117. Kurosawa H, Kohzuki M. Visualization of airflow limitation in emphysematous lung. N Eng J Med. 2004; 350: 1036.
118. Minami N, Mori N, Nagasaka M, et al. Effect of high-salt diet or chronic captopril treatment on exercise capacity in normotensive rats. Clin Exp Pharmacol Physiol. 2004; 31: 197-201. doi: 10.1111/j.1440-1681.2004.03980.x
119. Chida K, Saito H, Nagasaka T, Otani H, Kohzuki M, Zuguchi M. Rapid-sequence phosphorus-31 magnetic resonance spectroscopy of the human heart using a 1.5t-clinical system. Acta Radiol. 2004; 45: 30-37. doi: 10.1080/02841850410003284
120. Kanazawa M, Kohzuki M, Yoshida K, et al. Enhanced renoprotective effect of an angiotensin-converting enzyme(ACE)inhibitor combined with αadrenergic antagonist in a spontaneous hypertensive rat with renal ablation. Hypertens Res. 2004; 27: 509-515.
121. Goto Y, Kurosawa H, Mori N, et al. Improved activities of daily living, psychological state, and health-related quality of life following lung volume reduction surgery for 12 months in patients with severe emphysema. Respirology. 2004; 9: 1-9.
122. Chida K, Saito H, Zuguchi M, et al. Does digital acquisition reduce patients skin dose in cardiac interventional procedures? An experimental study. Am J Roentogenol. 2004; 183: 1111-1114.
123. Han CW, Lee EJ, Iwaya T, Kataoka H, Kohzuki M. Development of the Korean version of Short-Form 36-Item Health Survey: health related QOL of healthy elderly peple and elderly patients in Korea. Tohoku J Exp Med. 2004; 203: 189-194. doi: http://dx.doi.org/10.1620/tjem.203.189
124. Han CW, Yajima Y, Lee EJ, Park CM, Nakajima K, Kohzuki M. Development and construct validation of the Korean competence scale. Tohoku J Exp Med. 2004; 203: 331-337. doi: http://dx.doi.org/10.1620/tjem.203.331
125. Goto Y, Kurosawa H, Mori N, Kurokawa Y, Hida W, Kohzuki M. Improved activities of daily living psychological state and health-related quality of life for 12 months following lung volume reduction surgery in patients with severe emphysema. Respirology. 2004; 9: 337-344. doi: 10.1111/j.1440-1843.2004.00591.x
126. Kawamura T, Yoshida K, Sugawara A, et al. Regulation of skeletal muscle peroxisome proliferator-activated receptor γ expression by exercise and angiotensin-converting enzyme inhibition in fructose-fed hypertensive rats. Hypertens Res. 2004; 27: 61-70. doi: http://dx.doi.org/10.1291/hypres.27.61
127. Yoshida K, Kohzuki M. Clinical and experimental aspects of olmesartan medoxomil, a new angiotensin II receptor antagonist. Cardiovasc Drug Rev. 2004; 22: 285-308.
128. Sarkis A, Ito O, Mori T, et al. Cytochrome P-450 dependent metabolism of arachidonic acid in the kidney of rats with diabetes insipidus. Am J Physiol Renal Physiol. 2005; 289: F1333-F1340. doi: 10.1152/ajprenal.00188.2005
129. Chida K, Otani H, Nagasaka T, et al. Feasibility of rapid-sequence 31P magnetic resonance spectroscopy in cardiac patients. Acta Radiol. 2005; 46: 386-390. doi: 10.1080/02841850510021283
130. Chida K, Zuguchi M, Sai M, et al. Optimization of tube potential-filter combinations for film-screen mammography a contrast detail phantom study. J Clin Imaging. 2005; 29: 246-250. doi: http://dx.doi.org/10.1016/j.clinimag.2004.11.003
131. Han CW, Yajima Y, Lee EJ, Nakajima K, Meguro M, Kohzuki M. Validity and utility of the craig hospital inventory of environmental factors for Korean Community-dwelling elderly with or without stroke. Tohoku J Exp. Med. 2005; 206: 41-49. doi: http://dx.doi.org/10.1620/tjem.206.41
132. Kanazawa M, Kohzuki M, Li L, et al. Disability prevention of chronic renal failure (CRF): enhanced effects of chronic exercise combined with angiotensin converting enzyme (ACE) inhibitor in rats with CRF. Proceedings of the 3rd World Congress of the International Society of Physical and Rehabilitation Medicine, Monduzzi Editore, Bologna. 2005; 697-700.
133. Kanazawa M, Kohzuki M, Kururi N, et al. The present details of cardiac rehabilitation and life style modification after acute myocardial infarction in Miyagi Prefecture, Japan. Proceedings of the 3rd World Congress of the International Society of Physical and Rehabilitation Medicine, Monduzzi Editore, Bologna. 2005; 593-595.
134. Ito O, Tan L, Sasaki Y, et al. Disability prevention of chronic renal failure (CRF): Effects of chronic exercise on cytochrome p-450 metabolism of arachidonic acid in rats. Proceedings of the 3rd World Congress of the International Society of Physical and Rehabilitation Medicine, Monduzzi Editore, Bologna. 2005; 701-704.
135. Nagasaka M, Kohzuki M, Dobsak P, Imachi H, Minami N. New strategy of physical therapy effect of low and high voltage electrical stimulation on angiogenesis in rat skeletal muscle. Proceedings of the 3rd World Congress of the International Society of Physical and Rehabilitation Medicine, Monduzzi Editore, Bologna. 2005; 845-848.
136. Nagasaka M, Kohzuki M, Dobsak P, Imachi H, Minami N. New strategy of physical therapy effect of short-term electrical stimulation on angiogenesis in rat skeletal muscle. Proceedings of the 3rd World Congress of the International Society of Physical and Rehabilitation Medicine, Monduzzi Editore, Bologna. 2005; 849-852.
137. Ogawa M, Kondo T, Shindo K, et al. Rehabilitation for incomplete paraplegia with severe complications following aortic replacement. Proceedings of the 3rd World Congress of the International Society of Physical and Rehabilitation Medicine, Monduzzi Editore, Bologna. 2005; 153-156.
138. Sasaki Y, Kanazawa M, Tufescu A, Ito O, Kohzuki M. Disability prevention of chronic renal failure (CRF): Effect of combination therapy with low protein diet, chronic exercise and angiotensin II receptor antagonist in rat with CRF. Proceedings of the 3rd World Congress of the International Society of Physical and Rehabilitation Medicine, Monduzzi Editore, Bologna. 2005; 711-714.
139. Tufescu A, Kohzuki M, Sasaki Y, et al. Disability prevention of chronic renal failure (CRF): Enhanced effects of chronic exercise combined with angiotensin II receptor antagonist in spontaneously type 2 diabetes mellitus rats with CRF. Proceedings of the 3rd World Congress of the International Society of Physical and Rehabilitation Medicine, Monduzzi Editore, Bologna. 2005; 693-696.
140. Harada T, Watanabe H, Mori N, et al. The effects of rehabilitation on lipid metabolism of stroke patients. Proceedings of the 3rd World Congress of the International Society of Physical and Rehabilitation Medicine, Monduzzi Editore, Bologna. 2005; 95-98.
141. Kohzuki M. Cardiac rehabilitation in Japan: prevalence, safety and future plans. J HK Coll Cardiol. 2006; 14: 43-45.
142. Kanazawa M, Kawamura T, Li L, et al. Combination of exercise and enalapril enhances renoprotective and peripheral effects in rats with renal ablation. Am J Hypertens. 2006; 19: 80-86. doi: 10.1016/j.amjhyper.2005.07.009
143. Minami N, Mori N, Nagasaka M, et al. Mechanism behind augmentation in baroreflex sensitivity after acute exercise in spontaneously hypertensive rats. Hypertens Res. 2006; 29: 117-122. doi: 10.1291/hypres.29.117
144. Dobsák P, Nováková M, Fiser B, et al. Electrical stimulation of skeletal muscles. An alternative to aerobic exercise training in patients with chronic heart failure? Int Heart J. 2006; 47: 441-453. doi: http://dx.doi.org/10.1536/ihj.47.441
145. Ito O, Nakamura Y, Tan L, et al. Expression of cytochrome P-450 4 enzymes in the kidney and liver: regulation by PPAR and species-difference between rat and human. Mol Cell Biochem. 2006; 284: 141-148. doi: 10.1007/s11010-005-9038-x
146. Nagasaka M, Kohzuki M, Fujii T, et al. effect of low-voltage electrical stimulation on angiogenic growth factors in ischaemic rat skeletal muscle. Clin Exp Pharmacol Physiol. 2006; 33: 623-627. doi: 10.1111/j.1440-1681.2006.04417.x
147. Dobsák P, Nováková M, Siegelová J, et al. Low-frequency electrical stimulation increases muscle strength and improves blood supply in patients with chronic heart failure. Circ J. 2006; 70: 75-82. doi: http://dx.doi.org/10.1253/circj.70.75
148. Chida K, Saito H, Otani H, et al. Relationship between fluoroscopic time, dose-area product, body weight, and maximum radiation skin dose in cardiac interventional procedures. AJR Am J Roentgenol. 2006; 186: 774-778.
149. Chida K, Otani H, Kohzuki M, et al. The relationship between plasma BNP level and the myocardial phosphocreatine/adenosine triphosphate ratio determined by phosphorus-31 magnetic resonance spectroscopy in patients with dilated cardiomyopathy. Cardiology. 2006; 106: 132-136. doi: 10.1159/000092767
150. Chida K, Saito H, Kagaya Y, et al. Indicators of the maximum radiation dose to the skin during percutaneous coronary intervention in different target vessels. Catheter Cardiovasc Interv. 2006; 68: 236-241. doi: 10.1002/ccd.20830
151. Han CW, Yajima Y, Nakajima K, Lee EJ, Meguro M, Kohzuki M. Construct validity of the Frenchay Activities Index for community-dwelling elderly in Japan. Tohoku J Exp Med. 2006; 210: 99-107. doi: http://dx.doi.org/10.1620/tjem.210.99
152. Goto Y, Saito M, Iwasaka T, et al. Poor implementation of cardiac rehabilitation despite broad dissemination of coronary interventions for acute myocardial infarction in Japan: a nationwide survey. Circ J. 2007; 71: 173-179. doi: http://dx.doi.org/10.1253/circj.71.173
153. Tajima M, Kohzuki M, Azuma S, Saeki S, Meguro M, Sugawara J. Difference in quality of life according to the severity of malocclusion in Japanese orthodontic patients. Tohoku J Exp Med. 2007; 212: 71-80.
154. Azuma S, Kohzuki M, Saeki S, Tajima M, Igarashi K, Sugawara J. Beneficial Effects of Orthodontic Treatment on Quality of Life in Patients with Malocclusion. Tohoku J Exp Med. 2008; 213.
155. Minami N, Mori N, Nagasaka M, et al. Exercise training fails to modify arterial baroreflex sensitivity in ovariectomized female rats. Tohoku J Exp Med. 2007; 211: 339-345. doi: http://dx.doi.org/10.1620/tjem.211.339
156. Minami N, Li Y, Guo Q, et al. Effects of angiotensin-converting enzyme inhibitor and exercise training on exercise capacity and skeletal muscle. J Hypertens. 2007; 25: 1241-1248.
157. Park HJ, Kim S, Yong JS, et al. Reliability and validity of the Korean version of Kidney Disease Quality of Life instrument (KDQOL-SF). Tohoku J Exp Med. 2007; 211: 321-329. doi: http://dx.doi.org/10.1620/tjem.211.321
158. Goto Y, Kohzuki M, Meguro M, Kurosawa H. Long-term beneficial effects of lung volume reduction surgery on quality of life in patients with chronic obstructive pulmonary disease. Tohoku J Exp Med. 2007; 213: 157-166. doi: http://dx.doi.org/10.1620/tjem.213.157
159. Jiang Z, Kohzuki M, Harada T, Sato T. Glutathione suppresses increase of serum creatine kinase in experimental hypoglycemia. Diabetes Res Clin Pract. 2007; 77: 357-362. doi: http://dx.doi.org/10.1016/j.diabres.2007.01.014
160. Chida K, Fuda K, Saito H, et al. Patient skin dose in cardiac interventional procedures: conventional fluoroscopy versus pulsed fluoroscopy. Catheter Cardiovasc Interv. 2007; 69: 115-121. doi: 10.1002/ccd.20961
161. Chida K, Kagaya Y, Saito H, et al. Total entrance skin dose: an effective indicator of maximum radiation dose to the skin during percutaneous coronary intervention. Am J Roentgenol. 2007; 189: W224-W227.
162. Chida K, Fuda K, Kagaya Y, et al. Influence of the target vessel on the location and area of maximum skin dose during percutaneous coronary intervention. Acta Radiol. 2007; 48: 846-850. doi: 10.1080/02841850701468875
163. Maeda M, Kohzuki M, Tanaka N, Nagata M, Maniwa S, Watanabe I. Clinico-physchological worker for rehabilitation service in Japan. Proceedings of the 4th World Congress of the International Society of Physical and Rehabilitation Medicine, Monduzzi Editore, Bologna. 2007.
164. Kanazawa M, Kawamura T, Li L, et al. Disability prevention of chronic renal failure (CRF): Enhanced renoprotective and peripheral effects of chronic exercise combined with angiotensin converting enzyme inhibitor in rats with CRF. Proceedings of the 4th World Congress of the International Society of Physical and Rehabilitation Medicine, Monduzzi Editore, Bologna. 2007; 699-702.
165. Nagasaka M, Dobsak P, Mori N, et al. The effect of electrical stimulation on skeletal muscle in patients with chronic obstructive pulmonary disease (COPD). Proceedings of the 4th World Congress of the International Society of Physical and Rehabilitation Medicine, Monduzzi Editore, Bologna. 2007; 647-649.
166. Nagasaka M, Dobsak P, Mori N, et al. The influence of electrical stimulation on skeletal muscle in patients with left ventricular assist device (LVAD). Proceedings of the 4th World Congress of the International Society of Physical and Rehabilitation Medicine, Monduzzi Editore, Bologna. 2007; 651-654.
167. Imanishi R, Kanazawa M, Ishida A, et al. The prognosis after a two-week, hospitalized recovery phase cardiac rehabilitation program in patients with acute myocardial infarction. Proceedings of the 4th World Congress of the International Society of Physical and Rehabilitation Medicine, Monduzzi Editore, Bologna. 2007; 613-616.
168. Ito D, Ito O, Cao P, Kanazawa M, Kohzuki M. Disability prevention of cardiovascular and chronic kidney diseases: Effect of exercise training on blood pressure and the expression of nitric oxide synthase in spontaneously hypertensive rats. Proceedings of the 4th World Congress of the International Society of Physical and Rehabilitation Medicine Monduzzi Editore, Bologna. 2007; 621-623.
169. Tufescu A, Kanazawa M, Ishida A, Lu H, Sasaki Y, Kohzuki M. Effects of combination therapy with chronic exercise (EX) and losartan (LOS) in spontaneously diabetes mellitus rats with nephropathy. Proceedings of the 4th world congress of the international society of physical and rehabilitation medicine, Monduzzi Editore, Bologna. 2007; 703-706.
170. Lu H, Kanazawa M, Ishida A, Tufescu A, Sasaki Y, Kohzuki M. Disability prevention of chronic renal failure (CRF): Combination of chronic exercise and antihypertensive therapy enhances renoprotective effects in rats with CRF. Proceedings of the 4th world congress of the international society of physical and rehabilitation medicine, Monduzzi Editore, Bologna. 2007; 695-698.
171. Tan L, Ito O, Niu K, et al. Disability prevention of metabolic syndrome: Effects of a combination therapy of exercise training and atorvastatin on plasma glucose and adipocytokine in Zucker fatty rats. Proceedings of the 4th World Congress of the International Society of Physical and Rehabilitation Medicine, Monduzzi Editore, Bologna. 2007; 625-627.
172. Svacinová H, Nováková M, Placheta Z, et al. Benefit of combined cardiac rehabilitation on exercise capacity and cardiovascular parameters in patients with type 2 diabetes. Tohoku J Exp Med. 2008; 215:103-111.
173. Guo Q, Minami N, Mori N, et al. Effects of antihypertensive drugs and exercise training on insulin sensitivity in spontaneously hypertensive rats. Hypertens Res. 2008; 31: 525-533. doi: 10.1291/hypres.31.525
174. Nakayama T, Hirose T, Totsune K, et al. Increased gene expression of urotensin II-related peptide in the hearts of rats with congestive heart failure. Peptides. 2008; 29: 801-808. doi: 10.1016/j.peptides.2007.12.018
175. Azuma S, Kohzuki M, Saeki S, Tajima M, Igarashi K, Sugawara J. Beneficial effects of orthodontic treatment on quality of life in patients with malocclusion. Tohoku J Exp Med. 2008; 214: 39-50. doi: http://dx.doi.org/10.1620/tjem.214.39
176. Tufescu A, Kanazawa M, Ishida A, et al. Combination of exercise and losartan enhances renoprotective and peripheral effects in spontaneously type 2 diabetes mellitus rats with nephropathy. J Hypertens. 2008; 26: 312-321. doi: 10.1097/HJH.0b013e3282f2450b
177. Mori N, Hirose T, Nakayama T, et al. Increased expression of urotensin II-related peptide and its receptor in kidney with hypertension or renal failure. Peptides. 2008. doi: 10.1016/j.peptides.2008.09.021
178. Hirose T, Totsune K, Mori N, et al. Increased expression of adrenomedullin 2/intermedin in rat hearts with congestive heart failure. Eur J Heart Fail. 2008; 10: 840-849. doi: 10.1016/j.ejheart.2008.06.020
179. Chida K, Nagasaka T, Kohzuki M, et al. Feasibility of cardiac MR examination during quantitative isometric muscular exercise. Acta Cardiol. 2008; 63: 547-552.
180. Kohzuki M, Kawamura T, Ishida A. Outpatient phase III cardiac rehabilitation (CR) and the training system of the masters of CR in Japan. J HK Coll Cardiol. 2008; 16(Suppl 1): A23-A28.
181. Kohzuki M, Nagasaka M, Dobsak P. Electrical stimulation of skeletal muscles in patients with heart failure: an alternative to aerobic training? J HK Coll Cardiol. 2008; 16(Suppl 1): A38-A42.
182. Dobsak P, Al-Gergawi S, Sigelova J, et al. Low-frequency electromyostimulation improves autonomic nervous regulation in patients with end-stage chronic heart failure. Proceedings of the 5th World Congress of the International Society of Physical and Rehabilitation Medicine. 2009; 23-25.
183. Nagasaka M, Dobsak P, Mori N, et al. Electrical stimulation would be an alternative to exercise training in patients with COPD. Proceedings of the 5th World Congress of the International Society of Physical and Rehabilitation Medicine. 2009; 82-83.
184. Mori N, Hirose T, Nakayama T, et al. Increased expression of urotensin II-related peptide and its receptor in kidney with hypertension or renal failure. Peptides. 2009; 30: 400-408. doi: 10.1016/j.peptides.2008.09.021
185. Mori N, Ohtsuki K, Yamamoto J, et al. The minute ventilation to carbon dioxide production relationship in patients undergoing hematopoietic stem cell transplantation. Proceedings of the 5th World Congress of the International Society of Physical and Rehabilitation Medicine. 2009; 75-77.
186. Hirose T, Takahashi K, Mori N, et al. Increased expression of urotensin II, urotensin II-related peptide and urotensin II receptor mRNAs in the cardiovascular organs of hypertensive rats: comparison with endothelin-1. Peptides. 2009; 30: 1124-1129. doi: 10.1016/j.peptides.2009.02.009
187. Takahashi K, Hirose T, Mori N, et al. The renin-angiotensin system, adrenomedullins and urotensin II in the kidney: possible renoprotection via the kidney peptide systems. Peptides. 2009; 30: 1575-1585. doi: 10.1016/j.peptides.2009.05.018
188. Hirose T, Mori N, Totsune K, et al. Gene expression of (pro)renin receptor is upregulated in hearts and kidneys of rats with congestive heart failure. Peptides. 2009; 30: 2316-2322. doi: 10.1016/j.peptides.2009.09.015
189. Imanishi R, Nakagawa H, Matsumoto K, et al. Lower urinary tract dysfunction in elderly people staying at a residential facility. Proceedings of the 5th World Congress of the International Society of Physical and Rehabilitation Medicine. 2009; 48.
190. Freeman S, Ebihara S, Ebihara T, et al. Olfactory stimuli and enhanced postural stability in older adults. Gait Posture. 2009; 29: 658-660. doi: 10.1016/j.gaitpost.2009.02.005
191. Cao P, Ito O, Guo Q, et al. Disability prevention of cardiovascular and chronic kidney diseases: Effect of a combination therapy with exercise training and superoxide dismutase mimetic on blood pressure and nitric oxide synthase in spontaneously hypertensive rats. Proceedings of the 5th World Congress of the International Society of Physical and Rehabilitation Medicine. 2009; 13-14.
192. Suda C, Kanazawa M, Yao Q, et al. Disability prevention of chronic renal failure (CRF): Effects of combination therapy with chronic exercise and G-CSF in rats with CRF. Proceedings of the 5th World Congress of the International Society of Physical and Rehabilitation Medicine. 2009; 120-121.
193. Chang Y, Ito O, Cao P, et al. Disability prevention of metabolic syndrome: Effects of exercise training on steatosis and fatty acid metabolisms in the liver of Zucker fatty rats. Proceedings of the 5th World Congress of the International Society of Physical and Rehabilitation Medicine. 2009; 18-19.
194. Chida K, Morishima Y, Masuyama H, et al. Effect of radiation monitoring method and formula differences on estimated physician dose during percutaneous coronary intervention. Acta Radiol. 2009; 50: 170-173. doi: 10.1080/02841850802616745.
195. Chida K, Inaba Y, Saito H, et al. Radiation dose of interventional radiology system using a flat-panel detector. Am J Roentgenol. 2009; 193: 1680-1685. doi: 10.2214/AJR.09.2747
196. Han CW, Lee EJ, Kohzuki M. Validity and reliability of the Frenchay Activities Index for community-dwelling elderly in South Korea. Tohoku J Exp Med. 2009; 217: 163-168. doi: http://dx.doi.org/10.1620/tjem.217.163
197. Lu H, Kanazawa M, Ishida A, et al. Combination of Chronic Exercise and Antihypertensive Therapy Enhances Renoprotective Effects in Rats with Renal Ablation. Am J Hypertens. 2009; 22: 1101-1106. doi: 10.1038/ajh.2009.148
198. Yamanda S, Ebihara S, Ebihara T, Yamasaki M, Arai H, Kohzuki M. Bacteriology of aspiration pneumonia due to delayed triggering of the swallowing reflex in elderly patients. Hosp Infect. 2010; 74: 399-401. doi: 10.1016/j.jhin.2009.08.011
199. Yamasaki M, Ebihara S, Ebihara T, Yamanda S, Arai H, Kohzuki M. Effects of capsiate on the triggering of the swallowing reflex in elderly patients with aspiration pneumonia. Geriatr Gerontol Int. 2010; 10: 107-109. doi: 10.1111/j.1447-0594.2009.00566.x
200. Ebihara S, Kohzuki M. Taste disturbance by angiotensin-converting enzyme inhibitors/angiotensin-2 receptor blockers. Kidney Int. 2010; 77: 649. doi: 10.1038/ki.2009.528
201. Hirose T, Mori N, Totsune K, et al. Increased expression of (pro)renin receptor in the remnant kidneys of 5/6 nephrectomized rats. Regul Pept. 2010; 159: 93-99.
202. Hirose T, Totsune K, Mori N, et al. Expression of adrenomedullin 2/intermedin, a possible reno-protective peptide, is decreased in the kidneys of rats with hypertension or renal failure. Am J Physiol Renal Physiol. 2010; 299: F128-F134.
203. Freeman S, Kurosawa H, Ebihara S, Kohzuki M. Caregiving burden for the oldest old: a population based study of centenarian caregivers in Northern Japan. Arch Gerontol Geriatr. 2010; 50: 282-291. doi: 10.1016/j.archger.2009.04.008.
204. Freeman S, Kurosawa H, Ebihara S, Kohzuki M. Understanding the oldest old in northern Japan: an overview of the functional ability and characteristics of centenarians. Geriatr Gerontol Int. 2010; 10: 78-84. doi: 10.1111/j.1447-0594.2009.00550.x
205. Kanezaki M, Ebihara S, Nikkuni E, et al. Perception of urge-to-cough and dyspnea in healthy smokers with decreased cough reflex sensitivity. Cough. 2010; 6: 1. doi: 10.1186/1745-9974-6-1
206. Chida K, Kato M, Saito H, et al. Optimizing patient radiation dose in intervention procedures. Acta Radiol. 2010; 51: 33-39. doi: 10.3109/02841850903229141
207. Guo Q, Minami N, Mori N, et al. Effects of estradiol, angiotensin-converting enzyme inhibitor and exercise training on exercise capacity and skeletal muscle in old female rats. Clin Exp Hypertens. 2010; 32: 1-8.
208. Ebihara S, Kohzuki M, Sumi Y, Ebihara T. Sensory stimulation to improve swallowing reflex and prevent aspiration pneumonia in elderly dysphagic people. J Pharmacol Sci. 2011; 115: 99-104.
209. Ebihara S, Ebihara T, Kanezaki M, et al. Aging deteriorated perception of urge-to-cough without changing cough reflex threshold to citric acid in female never-smokers. Cough. 2011; 7: 3. doi: 10.1186/1745-9974-7-3
210. Ebihara S, Ebihara T, Yamasaki M, Kohzuki M. Stimulating oral and nasal chemoreceptors for preventing aspiration pneumonia in the elderly. Yakugaku Zasshi. 2011; 131(12): 1677-1681. doi: http://dx.doi.org/10.1248/yakushi.131.1677
211. Ohishi J, Kurosawa H, Ogawa H, Irokawa T, Hida W, Kohzuki M. Application of impulse oscillometry for within-breath analysis in patients with chronic obstructive pulmonary disease: pilot study. BMJ Open. 2011; 1: e000184. doi: 10.1136/bmjopen-2011-000184
212. Cao P, Ito O, Guo Q, et al. Endogenous hydrogen peroxide upregulates the expression of nitric oxide synthases in the kidney of spontaneously hypertensive rats. J Hypertens. 2011; 29: 1167-1174.
213. Sakata Y, Ito O, Watanabe H, Kohzuki M. The implementation of cardiac rehabilitation after acute myocardial infarction in Northern Japan. Proceedings of the 6th World Congress of the International Society of Physical and Rehabilitation Medicine. 2011; 38-39.
214. Rong R, Ito O, Mori N, Cao P, Kohzuki M. Exercise training decreases the enhanced expression of soluble (pro)renin receptor in the kidney of spontaneously hypertensive rats. Proceedings of the 6th World Congress of the International Society of Physical and Rehabilitation Medicine. 2011; 40-41.
215. Tamura Y, Mori N, Xu T, et al. Combined management program effects of chronic heart failure rehabilitation. Proceedings of the 6th World Congress of the International Society of Physical and Rehabilitation Medicine. 2011; 107-108.
216. Kim M, Ito O, Mori N, Nagasaka M, Ebihara S, Kohzuki M. The effect of exercise training on walking ability and health-related quality of life in patients with peripheral arterial disease. Proceedings of the 6th World Congress of the International Society of Physical and Rehabilitation Medicine. 2011; 36-37.
217. Sakuyama A, Ito O, Cao P, Ron R, Ito D, Kohzuki M. Effects of exercise training on the expression of angiotensin-converting enzyme in the kidney of spontaneously hypertensive rats. Proceedings of the 6th World Congress of the International Society of Physical and Rehabilitation Medicine. 2011; 143-144.
218. Kohzuki M, Sakata Y, Kawamura T, Ebihara S, Ito O. A paradigm shift in rehabilitation Medicine: From adding life to years to adding life to years and years to life. Asian Journal of Human Services. 2012; 2: 1-7.
219. Niu K, Asada M, Okazaki T, et al. Adiponectin pathway attenuates malignant mesothelioma cell growth. Am J Respir Cell Mol Biol. 2012; 46: 515-523. doi: 10.1165/rcmb.2011-0068OC
220. Liu M, Kohzuki M, Hamamura A, et al. How did rehabilitation professionals act when faced with the Great East Japan earthquake and disaster? Descriptive epidemiology of disability and an interim report of the relief activities of the ten Rehabilitation-Related Organizations. J Rehabil Med. 2012; 44: 421-428. doi: : 10.2340/16501977-0957
221. Ebihara S, Ebihara T, Kohzuki M. Effect of aging on cough and swallowing reflexes: implications for preventing aspiration pneumonia. Lung. 2012; 190: 29-33. doi: 10.1007/s00408-011-9334-z
222. Ebihara S, Nikkuni E, Ebihara T, Sakamoto Y, Freeman S, Kohzuki M. Effects of olfactory stimulation on gait performance in frail older adults. Geriatr Gerontol Int. 2012; 12: 567-568. doi: 10.1111/j.1447-0594.2011.00801.x
223. Ebihara S, Niu K, Ebihara T, et al. Impact of Blunted Perception of Dyspnea on Medical Care Use and Expenditure, and Mortality in Elderly People. Front Physiol. 2012; 3: 238. doi: 10.3389/fphys.2012.00238.
224. Miura M, Seki K, Ito O, Handa Y, Kohzuki M. Electrical stimulation of the abdomen preserves motor performance in the inactive elderly: a randomized controlled trial. Tohoku J Exp Med. 2012; 228: 93-101. doi: http://dx.doi.org/10.1620/tjem.228.93
225. Miura M, Seki K, Ito O, Handa Y, Kohzuki M. Functional Changes in the care-needing elderly after surface electrical stimulation to the abdomen. J Jpn Phys Ther Assoc. 2012; 15: 15-20. doi: http://dx.doi.org/10.1298/jjpta.Vol15_003
226. Muroya Y, Ito O, Ron R, et al. Disorders of fatty acid metabolism in the kidney of puromycin aminonucleoside-induced nephrotic rats. Am J Physiol Renal Physiol. 2012; 303: F1070-F1079. doi: 10.1152/ajprenal.00365.2011
227. Sakamoto Y, Ebihara S, Ebihara T, et al. Fall prevention using olfactory stimulation with lavender odor in elderly nursing home residents: a randomized controlled trial. J Am Geriatr Soc. 2012; 60: 1005-1011. doi: 10.1111/j.1532-5415.2012.03977.x
228. Kanezaki M, Ebihara S, Gui P, Ebihara T, Kohzuki M. Effect of cigarette smoking on cough reflex induced by TRPV1 and TRPA1 stimulations. Respir Med. 2012; 106: 406-412. doi: 10.1016/j.rmed.2011.12.007
229. Gui P, Ebihara S, Kanezaki M, et al. Urge-to-cough and dyspnea conceal perception of pain in healthy adults. Respir Physiol Neurobiol. 2012; 181: 214-219. doi: 10.1016/j.resp.2012.03.010.
230. Kashiwazaki N, Ebihara S, Gui P, et al. Inhibitory effect of cervical trachea and chest wall vibrations on cough reflex sensitivity and perception of urge-to-cough in healthy male never-smokers.  Cough. 2013; 9(1): 22. doi: 10.1186/1745-9974-9-22
231. Ebihara S, Ebihara T, Gui P, Osaka K, Sumi Y, Kohzuki M. Thermal Taste and Anti-Aspiration Drugs: a Novel Drug Discovery against Pneumonia.  Curr Pharm Des. 2013.
232. Ito D, Ito O, Mori N, et al. Exercise training upregulates nitric oxide synthases in the kidney of rats with chronic heart failure. Clin Exp Pharmacol Physiol. 2013; 40(9): 617-625. doi: 10.1111/1440-1681.12130
233. Ebihara S, Shannon F, Sakamoto Y, Ebihara T, Kohzuki M. Response letter to Lakin and Doe. J Am Geriatr Soc. 2013; 61(2): 313-314. doi: 10.1111/jgs.12108
234. Ito D, Ito O, Cao P, et al. Effects of exercise training on nitric oxide synthase in the kidney of spontaneously hypertensive rats. Clin Exp Pharmacol Physiol. 2013; 40(2): 74-82. doi: 10.1111/1440-1681.12040
235. Kohzuki M、Sakata Y, Mori N, Ebihara S, Ito S. Renal rehabilitation in patients with chronic kidney disease. Proceedings of the 7th World Congress of the International Society of Physical and Rehabilitation Medicine. 2013; 5-6.
236. Kohzuki M, Dobsak P, Magasaka M, Sakata Y, Ito S. Electrical stimulation of skeletal muscles and aerobic training in patients with heart failure. Proceedings of the 7th World Congress of the International Society of Physical and Rehabilitation Medicine. 2013; 63-64.
237. Miura M, Nagasaka M, Ito O, Kawai Y, Kohzuki M. Short term and long term effects of lower body positive pressure (LBPP) exercise for late elderly patients. Proceedings of the 7th World Congress of the International Society of Physical and Rehabilitation Medicine. 2013; 139-140.
238. Suzuki F, Ito O, Mori N, et al. Effect of cardiac rehabilitation on exercise tolerance, instrumental activities of daily living (IADL) and quality of life (QOL) in severe heart failure treated with implantable left ventricular device (LVAD). Proceedings of the 7th World Congress of the International Society of Physical and Rehabilitation Medicine. 2013; 141-143.
239. Sakata Y, Ito O, Watanabe H, Kohzuki M. The present situation of phase II cardiac rehabilitation for acute myocardial infarction at clinics in Japan. Proceedings of the 7th World Congress of the International Society of Physical and Rehabilitation Medicine. 2013; 143-144.
240. Ito K, Ebihara S, Gui P, Kashiwazaki N, Sato R, Kohzuki M. Pulmonary rehabilitation and gustation in patients with chronic obstructive pulmonary disease. Proceedings of the 7th World Congress of the International Society of Physical and Rehabilitation Medicine. 2013; 190-191.
241. Miura M, Ito O, Nagasaka M, Kohzuki M. Effects of electrical stimulation to skeletal muscle and exercise on the autonomic nervous activity. Proceedings of the 7th World Congress of the International Society of Physical and Rehabilitation Medicine. 2013; 192.
242. Sakai H, Kohzuki M, Kamide N, Jia T, Monma S, Ichie M. Geriatric rehabilitation in elderly people: relationship between depression and attitude/habituation to music. Proceedings of the 7th World Congress of the International Society of Physical and Rehabilitation Medicine. 2013; 200-201.
243. Kakihana T, Ito O, Suzuki F, Kohzuki M. Effect of exercise training for intermittent claudication due to incomplete persistent sciatic artery. Proceedings of the 7th World Congress of the International Society of Physical and Rehabilitation Medicine. 2013; 202-203.
244. Tanaka N, Miura M, Nagasaka M, Iguchi M, Ito O, Kohzuki M. Electric stimulation to the abdomen preserves activities of the elderly with chronic indwelling urinary catheter. Proceedings of the 7th World Congress of the International Society of Physical and Rehabilitation Medicine. 2013; 208.
245. Jia T, Miura M, Ito O, Nagasaka M, Rong R, Kohzuki M. Effects of music therapy and combination therapy on autonomic nervous activity. Proceedings of the 7th World Congress of the International Society of Physical and Rehabilitation Medicine. 2013; 209.
246. Tamura Y, Mori N, Gui P, et al. Comparison of the waiting period to begin rehabilitation between in Japan and China with the cerebral infarction. Proceedings of the 7th World Congress of the International Society of Physical and Rehabilitation Medicine. 2013; 246.
247. Mori N, Kashiwazaki N, Ito K, et al. Exercise performance after the radiofrequency catheter ablation. Proceedings of the 7th World Congress of the International Society of Physical and Rehabilitation Medicine. 2013; 280-281.
248. Kohzuki M. The significance of comprehensive rehabilitation. Total Rehabilitation Research. 2014 ; 1: 1-11.
249. Kohzuki M. Pulmonary rehabilitation in multimorbidity and multiple disabilities. Pulm Res Respir Med Open J. 2015; 2(2): e1-e2. doi: 10.17140/PRRMOJ-2-e001
250. Kohzuki M, Ebihara S. Taste sensitivity and nutrition in COPD rehabilitation. Pulm Res Respir Med Open J. 2016; 3(1): e1-e2. doi: 10.17140/PRRMOJ-3-e004

Hunain Alam, PhD

Odyssey Fellow
Department of Molecular & Cellular Oncology
The University of Texas MD Anderson Cancer Center
1515 Holocombe Blvd. Rm Y7.6020
Houston, Texas-77030, USA

BiographyResearch InterestScientific ActivitiesPublications
EDUCATION QUALIFICATION


• (1998-2001) BSc, Chemistry, Aligarh Muslim University, Aligarh, India
• (2002-2004) MSc, Toxicology, JamiaHamdard, New Delhi, India
• (2005-2011) PhD, Biochemistry, Cancer Research Institute (CRI), ACTREC, India

His current research is to investigate the Oncogenic functions of epigenetic modifiers in the development of Non-Small Cell Lung Cancer (NSCLC). Specifically, he plan to validate the tumor promoting functions of various histone demethylases and readers proteins using lung specific knockout mouse model and try to understand underlying tumor promoting mechanisms using Microarray and ChipSeq analysis.

AWARDS AND FELLOWSHIPS


• (2013) Odyssey Fellowship Award, MD Anderson Cancer Center
• (2005) Short listed for Shyama Prasad Mukherjee Fellowship Test
• (2004) Council of Scientific and Industrial Research National Eligibility Test- Junior Research Fellowship
• (2004) Council of Scientific and Industrial Research National Eligibility Test- Junior Research Fellowship
• (2004) Indian council of Medical Research Junior Research Fellowship
• (2004) Graduate Aptitude Test in Engineering


PROFESSIONAL SOCIETIES/MEMBERSHIP


• American Association for Cancer Research (AACR)
• American Society for Cell Biology (ASCB)
• All India Cell Biology Society (AICB)
• Indian Association for Cancer Research (IACR)

1. Klause W, Alam H, Giri U, et al. KDM2A promotes lung tumorigenesis by epigenetically enhancing ERK1/2 signaling. J Clin Invest. 2013. doi: 10.1172/JCI68642
2. Dhar SS, Alam H, Li N, et al. Transcriptional repression of histone deacetylase 3 by the histone demethylase kdm2a is coupled to tumorigenicity of lung cancer cells. J Biol Chem. 2014. doi: 10.1074/jbc.M113.521625
3. Alam H, Kundu S, Dalal S, Vaidya M. Loss of keratins 8 and 18 leads to alterations in α6β4-integrin-mediated signalling and decreased neoplastic progression in oral-tumor-derived cell line. J. Cell Science. 2011; 124(12): 2096-2106. doi: 10.1242/jcs.073585
4. Alam H, Sehgal L, Kundu S, Dalal S, Vaidya M. Novel function of keratin 5 and 14 in proliferation and differentiation of stratified epithelial cells. Molecular Biology of the Cell. 2011; 22(21): 4068-4078. doi: 10.1091/mbc.E10-08-0703
5. Alam H, Bhate A, Gangadaran P, et al. Loss of kertain 8 phosphorylation leads to increased tumor progression and correlates with clinico-pathological parameters of OSCC patients. PLoS One. 2011; 6(11): e27767. doi: 10.1371/journal.pone.0027767
6. Alam H, Bhate A, Gangadaran P, et al. Fascin overexpression promotes neoplastic progression in oral squamous cell carcinoma. BMC Cancer. 2012; 12: 32. doi: 10.1186/1471-2407-12-32
6. Dhar SS, Alam H, Li N, et al. Transcriptional repression of histone deacetylase 3 by the histone demethylase kdm2a is coupled to tumorigenicity of lung cancer cells. J Biol Chem. 2014. doi: 10.1074/jbc.M113.521625
7. Sehgal L, Mukhopadhyay A, Rajan A, et al. 14-3-3γ meditated transport of plakoglobin to the cell border is required for the initiation of desmosome assemblyin vitro and in vivo. J Cell Sci. 2014. doi: 10.1242/jcs.125807
8. Khapare N, Kundu S, Sehgal L, et al. Plakophilin3 loss leads to an increase in PRL3 levels promoting K8 dephosphorylation, which is required for transformation and metastasis. PLoS One. 2012; 7(6): e38561. doi: 10.1371/journal.pone.0038561
9. Iyer SV, Dange PP, Alam H, et al. Understanding the role of keratins 8 and 18 in neoplastic potential of breast cancer derived cell lines. PLoS One. 2013; 8(1): e53532. doi: 10.1371/journal.pone.0053532
10. Sawant S, Vaidya M, Chaukar D, et al. Clinical significance of aberrant vimentin expression in oral premalignant lesions and carcinomas. Oral Dis. 2014. doi: 10.1111/odi.12151

Juan R. Sanchez-Esteban, MD

Associate Professor of Pediatrics
Department of Pediatrics
The Warren Alpert Medical School of Brown University
Women and Infants Hospital of Rhode Island
101 Dudley Street
Providence, Rhode Island
USA

BiographyResearch InterestScientific ActivitiesPublications

Dr. Sanchez-Esteban received his MD at the Autonomous University of Barcelona, Spain and completed his fellowship in Neonatal-Perinatal Medicine at Women and Infants Hospital of Rhode Island and Brown University, Providence, RI USA where he is currently an Associate Professor of Pediatrics and staff neonatologist.

His research interests include: Mechanical forces in fetal lung development, Lung injury in prematurity.

MEMBERSHIPS


• (1988-1994) Catalan Society of Neonatology, Barcelona, Spain
• (1995-Present) American Academy of Pediatrics
• (1997-Present) New England Perinatal Society
• (1998-2009) Eastern Society for Pediatric Research
• (2000-Present) American Thoracic Society
• (2001-Present) American Physiological Society
• (2001-2010) The American Society for Cell Biology
• (2003-Present) Society for Pediatric Research

ORIGINAL PUBLICATIONS IN PEER-REVIEWED JOURNALS


1. Roig Quilis M, Sanchez Esteban J, Lombes A, et al. Clinical and Biochemical heterogeneity of childhood cytochrome C deficiency. Review of the literature. An Esp Pediatr. 1991; 34(2): 115-122.
2. Sanchez-Esteban J, Tsai SW, Sang J, Qin J, Torday JS, Rubin LP. Effects of Mechanical Forces on Lung-Specific Gene Expression. Am J Med Sci. 1998; 316(3): 200-204. doi: 10.1097/00000441-199809000-00009
3. Torday JS, Sanchez-Esteban J, Rubin LP. Paracrine Mediators of Mechanotransduction in Lung Development. Am J Med Sci. 1998; 316(3): 205-208. doi: 10.1097/00000441-199809000-00010
4. Sanchez-Esteban J, Cicchiello L, et al. Mechanical Stretch Promotes Alveolar Epithelial Type II Cell Differentiation. J Appl Physiol. 2001; 91: 589-595.
5. Sanchez-Esteban J, Wang Y, Cicchiello L, Rubin LP. Cyclic Mechanical Stretch Inhibits Cell Proliferation and Induces Apoptosis in Fetal Rat Lung Fibroblasts. Am. J Physiol Lung Cell Mol Physiol. 2002; 282(3): L448-L456. doi: 10.1152/ajplung.00399.2000
6. Sanchez-Esteban J, Wang Y, Gruppuso PA, Rubin LP. Mechanical stretch Induces Fetal Type II Cell Differentiation via an EGFR-ERK Signaling Pathway. Am J Resp Cell Mol Biol. 2004; 30(1): 76-83. doi: 10.1165/rcmb.2003-0121OC
7. Sanchez-Esteban J, Wang Y, Filardo EJ, Rubin LP, Ingber DE. Integrins β1, α6 and α3 contribute to mechanical strain-induced differentiation of fetal lung type II epithelial cells via distinct mechanisms. Am J Physiol Lung Cell Mol Physiol. 2006; 290: L343-L350.
8. Wang Y, Maciejewski BS, Weissman G, Silbert O, Han H, Sanchez-Esteban J. DNA microarray reveals novel genes induced by mechanical forces in fetal lung type II epithelial cells. Pediatr.Res. 2006; 60: 118-124.
9. Wang Y, Maciejewski BS, Lee N, et al. Strain-induced fetal type II epithelial cell differentiation is mediated via cAMP-PKA-dependent signaling pathway. Am J Physiol Lung Cell Mol Physiol. 2006; 291: L820-L827. doi: 10.1152/ajplung.00068.2006
10. Lee HS, Wang Y, Maciejewski BS, et al. Interleukin-10 Protects Cultured Fetal Rat Type II Epithelial cells from Injury Induced by Mechanical Stretch. Am J Physiol Lung Cell Mol Physiol. 2008; 294: L225-L232.
11. Silbert O, Wang Y, Maciejewski BS, Lee HS, Shaw SK, Sanchez-Esteban J. Roles of RhoA and Rac1 on actin remodeling, cell alignment and differentiation in fetal type II epithelial cells exposed to cyclic mechanical stretch. Exp Lung Res. 2008; 34: 663-680. doi: 10.1080/01902140802339615
12. Wang Y, Maciejewski BS, Soto-Reyes D, Lee HS, Warburton D, Sanchez-Esteban J. Mechanical stretch promotes fetal type II epithelial cell differentiation via shedding of HB-EGF and TGF-α. J Physiol. 2009; 587(8): 1739-1753. doi: 10.1113/jphysiol.2008.163899
13. Wang Y, Maciejewski BS, Drouillard D, et al. A role for caveolin-1 in mechanotransduction of fetal type II epithelial cells. Am. J. Physiol Lung Cell Mol Physiol. 2010; 298: L775 - L783.
14. Hawwa RL, Hokenson MA, Wang Y, Huang Z, Sharma S, Sanchez-Esteban J. IL-10 inhibits inflammatory cytokines released by fetal mouse lung fibroblasts exposed to mechanical stretch. Pediatr. Pulmonol. 2011; 46(7): 640-649. doi: 10.1002/ppul.21433
15. Hawwa RL, Hokenson MA, Wang Y, Huang Z, Sharma S, Sanchez-Esteban J. Differential expression of MMP-2 and -9 and their inhibitors in fetal lung cells exposed to mechanical stretch: Regulation by IL-10. Lung. 2011; 189(4): 341-349.
16. Lu Q, Sakhatskyy P, Grinnell K, et al. Cigarette Smoke Causes Endothelial Barrier Dysfunction via Oxidative Stress-Mediated Inhibition of RhoA and Focal Adhesion Kinase . Am. J. Physiol Lung Cell Mol Physiol. 2011; 301(6): L847-L857.doi: 10.1152/ajplung.00178.2011
17. Wang Y, Huang Z, Nayak PS, Sanchez-Esteban J. An experimental system to study mechanotransduction in fetal lung cells. J Vis Exp. 2012; 60: 3543. doi: 10.3791/3543
18. Huang Z, Wang Y, Nayak PS, Dammann CE, Sanchez-Esteban J. Stretch-induced fetal type II cell differentiation is mediated via ErbB1-ErbB4 interactions. J Biol Chem. 2012; 287(22): 18091-18102. doi: 10.1074/jbc.M111.313163
19. Hokenson MA, Wang Y, Hawwa RL, Huang Z, Sharma S, Sanchez-Esteban J. Reduced IL-10 production in Fetal Type II Epithelial Cells Exposed to Mechanical Stretch is Mediated via Activation of IL-6-SOCS3 Signaling Pathway. PLoS One. 2013; 8(3): e59598. doi: 10.1371/journal.pone.0059598
20. Wang Y, Huang Z, Nayak PS, et al. Strain-induced differentiation of fetal type II epithelial cells is mediated via integrin α6β1-ADAM17 signaling pathway. J Biol Chem. 2013; 288: 25646-25657. doi: 10.1074/jbc.M113.473777
21. Sanchez-Esteban J. Growth factors and fetal lung development mediated by mechanical forces. World J Respirol. 2013; 3(3): 44-47.
22. Sanchez-Esteban J. Mechanical Forces in Fetal Lung Development: Opportunities for Translational Research. Front Pediatr. 2013; 25(1): 51.
23. Giordani VM, DeBenedictus CM, Wang Y, Sanchez-Esteban J. Epidermal Growth Factor Receptor (EGFR) contributes to fetal lung fibroblast injury induced by mechanical stretch. J Recept Signal Transduct Re. 2014; 34(1): 58-63. doi: 10.3109/10799893.2013.862270
24. Najrana T, Sanchez-Esteban J. Alveolar Type I epithelial cells: The forgotten cells in fetal lung development and lung injury. Pulm Res Respir Med Open J. 2016; 2(4): e6-e9. doi: 10.17140/PRRMOJ-2-e003

Bianca Bergamo De Araujo Paulino, PhD

Department of Pathology
São Paulo University Medical School
Av. Dr. Arnaldo, 455
01246-903, Sao Paulo, Brazil

BiographyResearch InterestScientific ActivitiesPublications

Dr. Paulino is a Post-doctorate Researcher in the Department of Pathology, Medical School, University of Sao Paulo, Brazil (2014). Dr. Paulino spent one year (2011) in the Medical School, University of Sheffield, UK - Department of Infection and Immunity, sponsored by an European Respiratory Society Long Term Research Fellowship (LTRF -MC1562-2010). She completed PhD from 2004 - 2009, at Department of Pathology of the Sao Paulo University. She completed Degree in Physical Therapy from the State University of Londrina, Brazil in 2002, and Respiratory Residency from University of Franca, Brazil in 2004.

Her research interests include: Airway smooth muscle, extracellular matrix, pulmonary rehabilitation, asthma and interstitial lung diseases.

AWARDS:

• Gold Sponsorship, European Respiratory Society – Munich/Germany, 2006
• Young Scientist, European Respiratory Society - Copenhagen/Denmark, 2005
• Bronze Sponsorship, European Respiratory Society - Vienna/Austria, 2003

1. Bingle L, Wilson K, Musa M, et al. BPIFB1 (LPLUNC1) is upregulated in cystic fibrosis lung disease. Histochem Cell Biol. 2012; 138(5): 749-758. doi: 10.1007/s00418-012-0990-8
2. Shiang C, Mauad T, Senhorini A, et al. Pulmonary perivascular inflammation in fatal asthma. Clinical and Experimental Allergy. 2009; 39: 1499-1507. doi: 10.1111/j.1365-2222.2009.03281.x
3. Dolhnikoff M, Silva LFF, Araújo BB, et al. The outer wall of small airways is a major site of remodeling in fatal asthma. Journal of Allergy and Clinical Immunology. 2009; 123: 1090-1097. doi: 10.1016/j.jaci.2009.02.032
4. Mauad T, Ferreira DS, Costa MBG, et al. Characterization of autopsy-proven fatal asthma patients in São Paulo, Brazil. Pan American Journal of Public Health. 2008; 23: 418-423. doi:
5. Araújo BB, Dolhnikoff M, Silva LFF, et al. Extracellular matrix components and regulators in the airway smooth muscle in asthma. The European Respiratory Journal. 2008; 32: 61-69. doi: 10.1183/09031936.00147807
6. Santos ABG, Binoki D, Silva LFF, et al. Immune Cell Profile in Infants Lung Tissue. Annals of Anatomy. 2013; 13: 116- 117. doi: 10.1016/j.aanat.2013.05.003

Islam M Ibrahim, MD, FACP, FCCP

Associate Clinical Professor
International Medical Center, KSA
Pulmonary and Critical care Medicine
University of California San Diego, USA

BiographyResearch InterestScientific ActivitiesPublications

Dr. Ibrahim is an Associate Clinical Professor of Pulmonary, Critical Care Medicine at the University Of California San Diego. He served as Clinical Associate Professor of Pulmonary Medicine Division, at N.E. Ohio University College of Medicine during 1999-2007. He joined the International Medical Center (IMC) as the Chairman of the Medicine Department in September 2005. He is the current External Examiner for Final Year Medical Students, King Abdul Aziz University, Jeddah, Saudi Arabia.
Dr. Ibrahim graduated from Cairo University in 1988, and then pursued training in Internal Medicine at Nassau County Medical Center in Long Island, New York. Dr. Ibrahim moved to the Albert Einstein College of Medicine, University Hospital in Bronx, New York. He then went on to be a valuable addition to the Pulmonary Medicine Fellowship Program at Mount Sinai University Hospital, New York. He soon after, joined the Albert Einstein College of Medicine Fellowship Program in Critical Care Medicine, Bronx, New York.
Dr. Ibrahim practiced Pulmonary Medicine at Ohio University affiliated hospital in Akron, Ohio from 1998 to 2005. From 2002 to 2004, he served as Chief of Medical Staff at Regency Hospital, Barberton, Ohio. Subsequently from 2003 till 2005, Dr. Ibrahim served as Chief of the Pulmonary Service, Director of Intensive Care Unit, and as Head of the Critical Care Committee at Doctors’ Hospital, Massillon, Ohio.
Dr. Ibrahim contributed to medical education by teaching doctors & medical students and was given the ‘Outstanding Specialty Physician Award’ from the Ohio University College of Medicine. He continually strives to educate medical professionals as a commitment to excellence in education and research.

His clinical interests include Global Challenges in Treating COPD, Diffuse Interstitial Lung Disease, Upper airway dysfunction induced dyspnea. His research also focuses on Tissue Culture techniques, TGF-BETA effect on the chemically injured retina, Effect of various growth factors on the Regeneration of the Pigmented, Epithelium in the White New Zealand Rabbit, Nocardiasis in HIV + Pleural Effusion.

PROFESSIONAL AFFILIATIONS

• Fellow, American College of Chest Physicians
• Fellow, American College of Physicians
• Member, American Thoracic Society
• Member, Saudi Thoracic Society
o Member, Jeddah Chest Club
• Member, Jeddah ICU Club


CURRENT SCIENTIFIC ACTIVITIES

• 2013 - Present ACCP, Counsel of Global Governors, Member
• 2011-Present Chair, Global education ad hoc group, The American college of chest physicians


ADMINISTRATIVE ACTIVITIES

2010 -Present Chairman, Medical Education Committee, International Medical Center

Chunbin Zou, MD, PhD

Research Assistant Professor of Medicine
Department of Medicine
Division of Pulmonary, Allergy, and Critical Care Medicine
University of Pittsburgh School of Medicine
W1253, BST, 200 Lothrop Street
Pittsburgh, PA, 15213, USA

BiographyResearch InterestScientific ActivitiesPublications

Dr. Zou received his MD and M.Sc. in Medical Science from China and PhD in Molecular and Cellular Biology from Japan. He completed his post-doctoral fellow training in Pharmaceutical Biochemistry at University of California at San Francisco School of Pharmacy and in Molecular and Cellular Pathology at University of Pittsburgh School of Medicine. In March 2010, Dr. Zou joined the Pulmonary, Allergy, and Critical Care faculty at the University of Pittsburgh as an Assistant Professor.
Dr. Zou’s research focuses on a novel epigenetic code histone O-palmitoylation and its pathophysiological significances. Dr. Zou serendipitously discovered a novel histone modification called histone O-palmitoylation that acts as a new epigenetic mark to regulate gene transcription. This line of research will add ample knowledge of a novel layer of epigenetic regulation both in basic and medical scientific fields. We will study the underlying molecular mechanism(s) of O-palmitoylation in alteration of chromatin architecture, in interplay with other layers of histone modifications, and the pathophysiological significance in acute and chronic respiratory diseases and lung cancers.
The related research interest in Dr. Zou’s laboratory is protein degradation. Utilizing the state-of-art interdisciplinary approaches, he is studying the signaling transduction in regulation of proteins in terms of protein degradation. He has uncovered several unstudied enzymes called E3 ubiquitin ligases that control the protein degradation of several important proteins in pneumonia lung tissues. He is actively to seek the possible small molecules that may interfere the protein degradation thus control the pathological progress of acute lung injury.

His research interests include: Acute Lung Injury, pneumonia, bacterial infection, inflammation, lipid biology, epigenetics, transcriptional regulation, histone modification, E3 ubiquitin ligase, and ubiquitin proteasomal degradation.

MEMBERSHIP in PROFESSIONAL and SCIENTIFIC SOCIETIES

• American Society for Biochemistry and Molecular Biology 2004
• American Heart Association 2012
• American Thoracic Society 2012


EDITORIAL BOARD MEMBER

• Pulmonology and Respiratory Research
• World Journal of Biological Chemistry


APPOINTMENTS, POSITIONS, AWARDS, AND HONORS

• 1991-1997 Huazhong University Tongji Medical School Assistant Professor
• 2004-2010 University of Pittsburgh School of Medicine Research Associate
• 2007 Pitt Innovator Award, University of Pittsburgh
• 2010-present University of Pittsburgh School of Medicine Assistant Professor
• 2012 Plenary speaker in Wuhan International Symposium on Biological Signaling Transduction, Wuhan, China. Title: “Lpcat1, a Surfactant Synthetic Enzyme or a Novel Epigenetic Mark?”
• 2014 Chair for the poster discussion section in epigenetics at American Thoracic Society (ATS) International Conference, San Diego, CA.

1. Chen J, Huang D, Chen W, et al. Linker-Extended Native Cyanovirin-N Facilitates PEGylation and Potently Inhibits HIV-1 by Targeting the Glycan Ligand. PLoS One. 2014; 9(1): e86455. doi: 10.1371/journal.pone.0086455
2. Chen Y, Li J, Dunn S, et al. Histone deacetylase 2 (HDAC2) protein-dependent deacetylation of mortality factor 4-like 1 (MORF4L1) protein enhances its homodimerization. J Biol Chem. 2014. doi: 10.1074/jbc.M113.527507
3. Zou C, Mallampalli RK. Regulation of histone modifying enzymes by the ubiquitin-proteasome system. BBA -Molecular Cell Research. 2014; 1843(4): 694-702.doi: 10.1016/j.bbamcr.2013.12.016
4. Mallampalli RK, Coon TA, Glasser JR, et al. Targeting F Box Protein Fbxo3 To Control Cytokine-Driven Inflammation. J Immunol. 2013; 191(10): 5247-5255. doi: 10.4049/jimmunol.1300456
5. Ma J, Zou C, Guo L, et al. A novel death defying domain in met entraps the active site of caspase-3 and blocks apoptosis in hepatocytes. Hepatology. 2013.doi: 10.1002/hep.26769
6. Chen BB, Coon TA, Glasser JR, et al. A combinatorial F box protein directed pathway controls TRAF adaptor stability to regulate inflammation. Nat Immunol. 2013; 14(5): 470-479. doi: 10.1038/ni.2565
7. Zhao J, Mialki RK, Wei J, et al. SCF E3 ligase F-box protein complex SCF(FBXL19) regulates cell migration by mediating Rac1 ubiquitination and degradation. FASEB J. 2013; 27(7): 2611-2619. doi: 10.1096/fj.12-223099
8. Zou C, Chen Y, Smith RM, et al. SCF(Fbxw15) mediates histone acetyltransferase binding to origin recognition complex (HBO1) ubiquitin-proteasomal degradation to regulate cell proliferation. J. Biol Chem. 2013; 288(9): 6306-6316. doi: 10.1074/jbc.M112.426882
9. Ellis B, Kaercher L, Snavely C, Zhao Y, Zou C. Lipopolysaccharide triggers nuclear import of Lpcat1 to regulate inducible gene expression in lung epithelia. W J Bio Chem. 2012; 3(7): 159-166. doi: 10.4331/wjbc.v3.i7.159
10. Zhao J, Wei J, Mialki RK, et al. F-box protein FBXL19-mediated ubiquitination and degradation of the receptor for IL-33 limits pulmonary inflammation. Nat Immunol. 2012; 13(7): 651-658. doi: 10.1038/ni.2341
11. Zhao J, Wei J, Mialki R, Zou C, Mallampalli RK, Zhao Y. Extracellular signal-regulated kinase (ERK) regulates cortactin ubiquitination and degradation in lung epithelial cells. J Biol Chem. 2012; 287(23): 19105-19114. doi: 10.1074/jbc.M112.339507
12. Chen BB, Glasser JR, Coon TA, et al. F-box protein FBXL2 targets cyclin D2 for ubiquitination and degradation to inhibit leukemic cell proliferation. Blood. 2012; 119(13): 3132-3141. doi: 10.1182/blood-2011-06-358911.
13. Zou C, Ellis BM, Smith RM, Chen BB, Zhao Y, Mallampalli RK. Acyl-CoA: lysophosphatidylcholine acyltransferase I (Lpcat1) catalyzes histone protein O-palmitoylation to regulate mRNA synthesis. J Biol Chem. 2011; 286(32): 28019-28025.doi: 10.1074/jbc.M111.253385
14. Zou C, Butler PL, Coon TA, et al. LPS impairs phospholipid synthesis by triggering beta-transducin repeat-containing protein (beta-TrCP)-mediated polyubiquitination and degradation of the surfactant enzyme acyl-CoA: lysophosphatidylcholine acyltransferase I (LPCAT1). J Biol Chem. 2011; 286(4): 2719-2727. doi: 10.1074/jbc.M110.192377
15. Dai JY, DeFrances MC, Zou C, Johnson CJ, Zarnegar R. The Met protooncogene is a transcriptional target of NF kappaB: implications for cell survival. J Cell Biochem. 2009; 107(6): 1222-1236. doi: 10.1002/jcb.22226
16. Ma J, DeFrances MC, Zou C, Johnson C, Ferrell R, Zarnegar R. Somatic mutation and functional polymorphism of a novel regulatory element in the HGF gene promoter causes its aberrant expression in human breast cancer. J Clin Invest. 2009; 119(3): 478-491. doi: 10.1172/JCI36640
17. Zou C, Ma J, Wang X, et al. Lack of Fas antagonism by Met in human fatty liver disease. Nat Med. 2007; 13(9): 1078-1085. doi: 10.1038/nm1625
18. Li Z, Zou C, Yao Y, et al. An easily dissociated 26 S proteasome catalyzes an essential ubiquitin-mediated protein degradation pathway in Trypanosoma brucei. J Biol Chem. 2002; 277(18): 15486-15498. doi: 10.1074/jbc.M109029200
19. Zou CB, Nakajima-Shimada J, Nara T, Aoki T. Cloning and functional expression of Rpn1, a regulatory-particle non-ATPase subunit 1, of proteasome from Trypanosoma cruzi. Mol Biochem Parasitol. 2000; 110(2): 323-331. doi: 10.1016/S0166-6851(00)00284-X
20. Nakajima-Shimada J, Zou C, Takagi M, Umeda M, Nara T, Aoki T. Inhibition of Fas-mediated apoptosis by Trypanosoma cruzi infection. Biochim Biophys Acta-General Subject. 2000; 1475(2): 175-183. doi: 10.1016/S0304-4165(00)00059-3

Alexandra B Firsova, PhD

Department of Biochemistry and Molecular Biology
Monash University, Clayton
VIC, Australia

BiographyResearch InterestScientific ActivitiesPublications

Dr. Firsova completed a Bachelor Degree (Biology, Cytology and Histology) at St. Petersburg State University, Russia, followed by a Master Degree (Biomedical Science) at Monash Institute of Medical Research, Australia, and a Doctoral Degree (Respiratory biology and stem cell therapy) at Monash University, Australia. She has been involved in undergraduate demonstrating in Monash University, and is planning to undertake a position at Karolinska Institutet, Sweden, to develop a pulmonary cell therapy project. Her area of expertise is bronchopulmonary dysplasia, neonatal lung deficit after hyperoxia and cell therapy.

Her research interests include: Lung disease, Lung injury, Hyperoxia, Vascular disease, Adult stem cells, Transplantation, Cell therapy.

CONFERENCE ATTENDED

• 2011 ComBio, Cairns, QLD, Australia (25 – 29 September 2011)
• 2010 Australian Health & Medical Research Congress, Melbourne, VIC, Australia (14 - 18 November 2010)
• Postgraduate student conference, Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC, Australia (11-12 November 2010)
• OzBio, Melbourne, VIC, Australia (21 September – 1 October 2010)
• International Society for Stem Cell Research Congress, Moscone West, San Francisco, CA, USA (16-19 June 2010)
• Genome Conference, Lorne, VIC, Australia (14-16 February 2010)
• 2009 Postgraduate Student Annual Conference, Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC, Australia (12-13 November 2009)
2008 Endocrine Society of Australia and Society of Reproductive Biology Scientifi c meeting, Melbourne Convention Centre, Melbourne, VIC, Australia (25-28 August 2008)
• 2007 International Society for Stem Cell Research Congress, Cairns, QLD, Australia (17 – 21 June 2007)
• CRC for the Innovative Dairy products Annual Conference, Gold Coast, QLD, Australia (13–15 June 2007)
• 2006 Australian Health and Medical Research Congress, Melbourne, Victoria, Australia (26 November - 1 December 2006)
• CRC for the Innovative Dairy products Annual Conference, Crowne Plaza, Coogee Beach, NSW, Australia. (2-4 August 2006)
• 2005 Postgraduate Student Symposium, Monash Institute of Medical Research, Clayton, Victoria, Australia (28- 30 November 2005)
• CRC for the Innovative Dairy products Annual Conference, Gold Coast, QLD, Australia. (7-9 July 2005)
• 2004 International Stem Cell Symposium, St. Petersburg, Russia (23-25 October 2004); and Fifth White Sea Conference, St Petersburg State University, St. Petersburg, Russia (6 February 2004)

JOURNAL PAPER ABSTRACTS:

1. Firsova AB, Cole TJ, Mollard R. Transient vascular and long-term alveolar defi cits following a hyperoxic injury to neonatal mouse lung. BMC Pulmonary Medicine. 2014; 14(1): 59. doi: 10.1186/1471-2466-14-59
2. Lim ML, Vassiliev I, Richings NM, Firsova AB, Zhang C, Verma PJ. A novel, effi cient method to derive bovine and mouse embryonic stem cells with in vivo diff erentiation potential by treatment with 5-azacytidine. Theriogenology. 2011; 76 (1): 133-42. doi: 10.1016/j.theriogenology.2011.01.027
3. Kozlova AB, Petukhova OA, Pinaev GP. Injury induced changing in cellular content of coelomic liquid of starfish Asterias rubens L. Tsitologiia. 2006; 48(3): 175-183.
4. Kozlova AB, Petuhova OA, Pinaev GP. Changes in coelomic fl uid cell composition of sea star Asterias rubens after the injury. Tsitologiia. 2004; 46(10): 919-920. br> 5. Kudryavtsev IV, Zlobina MV, Baskakov AV, et al. Analysis of the mechanisms of innate immunity of sea star Asterias rubens. Vestnik of St.Petersburg State University. 2004; 3(4): 69-75.

Chien-Wei Hsu, MD

Assistant Professor
Division of Critical Care
Department of Internal Medicine
Kaohsiung Veterans General Hospital
386, Ta-Chung First Road, Kaohsiung
Taiwan 813, Republic of China

BiographyResearch InterestScientific ActivitiesPublications

Dr. Chien-Wei Hsu is a Assistant Professor at the Department of Internal Medicine, Kaohsiung Veterans General Hospital, Republic of China since 1999.

His research interests include: ICU sedation, Mechanical ventilation, Pneumothorax, Nutritional therapy, Glycemic control

PROFESSIONAL SOCIETIES

• The Society of Internal Medicine, ROC
• The Society of Pulmonary and Critical Care Medicine, ROC
• The Society of Emergency and Critical Care, ROC

1. Hsu CW, Wang HC , Lu JY. Small cell lung carcinoma associated with para-neoplastic limbic encephalitis. J Formos Med Assoc. 1999; 98: 368-371.
2. Hsu CW, Chu KA, Ti Lu, Lai RS, Lu JY. Ethambutol induced psychosis : a case report. Chinese Medical Journal. 1999; 62: 724-727.
3. Hsu CW, Chu KA, Lu JY, Chang HC, Lin CH. Primary pleural low-grade lymphoma - a case report. Thorac Med. 1999; 14: 121-126. doi: doi: 10.1136/thorax.58.10.908
4. Sun SH, Mei SC, Hsu CW, Hung KH, Lai PH. Cerebral infarction due to traumatic internal carotid artery dissection: a case report and review of the literature. J Rehab Med Assoc ROC. 1999; 27: 241-248.
5. Hsu CW, Wann SR, Chiang HT, Lin CH, Kung MH, Lin SL. Comparison of the APACHE II and APACHE III scoring system in patients with respiratory failure in a medical intensive care unit. J Formos Med Assoc. 2001; 100: 437-442.
6. Leu YJ, Lin CH, Hsu CW, Chen CJ, Lai PH, Lu JY. Adenocarcinoma of the lung complicated with leptomeningeal carcinomatosis- report of two cases. Thoracic Medicine. 2003; 18: 246-520.
7. Lin SL, Huang WC, Wann SR, et al. Impact of quality improvement program in reducing the catheter-associated urinary tract infection in intensive care units. Crit Care and Shock . 2004; (suppl 1)7(2): 182.
8. Huang WC, Wann SR, Lin SL, et al. Catheter-associated urinary tract infections in intensive care units can be reduced by prompting physicians to remove unnecessary catheters. Infection Control and Hospital Epidemiology. 2004; 25: 974-978. doi: 10.1086/502329
9. Lee DL, Hsu CW, Lee H, et al. Beneficial effects of albuterol therapy driven by heliox by oxygen in severe asthma exacerbation. Academic Emergency Medicine. 2005; 12(9): 820-827. doi: 10.1197/j.aem.2005.04.020
10. Lin YP, Hsu CW, et al. The role of fentanyl injection in intensive care unit. Journal of Internal Medicine of Taiwan. 2005; 16: 211-215.
11. Sun SH, Hwang CW, Hsu CW, et al. Intraarticular injection of sodium hyaluronate in adhesive capsulitis of the shoulder. Journal of Rehabilitation medical Association. 2005; 33(4): 221-227.
12. Huang NC, Hung YM, Lin SL, et al. Further evidence of the usefulness of acute physiology and chronic health evaluation II scoring system in acute paraquat poisoning. Clinical Toxicology. 2006; 44: 99-102. doi: 10.1080/15563650500514251
13. Chang R, Hsu CW, Lin CH, et al. Massive hemoptysis due to an anomalous origin of the right pulmonary artery from the acending aorta- a case report. Thoracic Medicine. 2006; 21: 168-174.
14. Chang R, Lai RS,Hsu CW, Kang PL. Scimitar syndrome variant causing massive hematemesis- a case report. Thoracic Medicine. 2006; 21: 190-195.
15. Sun SH, Hsu CW, Hwang CW, et al. Hyaluronate improves pain, physical function and balance in the geriatric osteoarthritis knee: a 6-month follow-up study using clinical tests. Osteoarthritis and Cartilage. 2006; 14(7): 696-701. doi: http://dx.doi.org/10.1016/j.joca.2006.01.010
16. Hsu CW, Lin SL, Sun SH, et al. Comparison of the diuretic effect of furosemide mixed with human albumin or fresh frozen plasma for patients with hypoalbuminemia in the intensive care unit. Journal of Nephrology. 2006; 19(5): 621-627.
17. Sun SH, Hsu CW, Hwang CW, et al. Efficacy of intra-articular hyaluronic acid in patients with osteoarthritis of the ankle: a prospective study. Osteoarthritis and Cartilage. 2006; 14(9): 867-874. doi: http://dx.doi.org/10.1016/j.joca.2006.03.003
18. Sun SH, Hsu CW, Hwang CW, et al. Application of combined botulinum toxin A and modified contraint-induced movement therapy for an individual with chronic upper extremity spasticity after stroke. Physical Therapy. 2006; 86(10): 1387-1397. doi: 10.2522/ptj.20050262
19. Chu KA, Wu YC, Lin MH, Hsu CW. Electroacupuncture results in bronchodilating response in asthma patients- Three cases report. Thoracic Medicine. 2007; 22: 47-52.
20. Hsu CW, Lee DL, Lin SL, Sun SH, Chang HW. The initial response to inhaled nitric oxide treatment for the ICU patients with acute respiratory distress syndrome. Respiration. 2008; 75: 288-296. doi: 10.1159/000101478)
21. Huang CM, Hsu CW, Hwang CW, et al. Therapists opinions of constraint-induced movement therapy: result of a survey in Taiwan. Journal of Taiwan Occupational Therapy Research and Practice. 2008; 4: 34-44.
22. Hsu CW, Lin SL, Sun SH. Glucose control, renal replacement therapy and blood product administration in severe sepsis patients. Taiwan Critical Care Medicine. 2009; 10: 57-65.
23. Hsu CW, Sun SH, Lin SL,et al. Duodenal versus gastric feeding in medical intensive care unit patients: a prospective, randomized, clinical study. Critical Care Medicine. 2009; 17(6): 1866-1872. doi: 10.1097/CCM.0b013e31819ffcda
24. Sun SH, Chou YJ, Hsu CW, Chen WL. Hyaluronic acid as a treatment for ankle osteoarthritis. Curr Rev Musculoskelet Med. 2009; 2(2): 78-82.
25. Sun SH, Hsu CW, Sun HP, et al. Combined Botulinum Toxin type A With Modified Constraint-Induced Movement Therapy for Chronic Stroke Patients with Upper Extremity Spasticity-A Randomized Controlled Study. Neurorehabilitation Neural Repair. 2010; 24(1): 34-41. doi: 10.1177/1545968309341060
26. Hsu CW, Sun SH, Lee DL, et al. Impact of Disease Severity on Gastric Residual Volume in Critical Patients. World Journal of Gastroenterology. 2011; 17(15): 2007-2012.
27. Sun SH, Hsu CW Sun HP, Chou YJ, Hung-Ju Li, Jue-Long Wang. The effect of three weekly intra-articular injections of hyaluronate on pain, function, and balance in patients with unilateral ankle arthritis. Journal of Bone and Joint Surgery. 2011; 93(18): 1720-1726. doi: 10.2106/JBJS.J.00315
28. Hsu CW. Glycemic control in critically ill patients. World Journal of Critical Care Medicine. 2012; 1(1): 31-39.
29. Hsu CW, Sun SH, Lin SL, Huang HH, Wong KF. Moderate glucose control results in less negative nitrogen balance in medical intensive care unit patients- a randomized controlled study. Critical Care. 2012; 16: R56. doi: 10.1186/cc11299
30. Huang HH, Chang SJ, Hsu CW, Chang TM, Kang SP, Liu MY. Severity of illness influences the efficacy of enteral feeding route on clinical outcomes in critically ill patients. Journal of American Diet Association. 2012; 112: 1138-1146. doi: 10.1016/j.jand.2012.04.013
31. Huang HH, Hsu CW, Kang SP, Liu MY, Chang SJ. Association between illness severity and timing of initial enteral feeding in critically ill patients: a retrospective observational study. Nutrition Journal. 2012; 11: 30. doi: 10.1186/1475-2891-11-30
32. Sun SH, Hsu CW, Chou YJ, et al. Effects of intra articular botulinum toxin A in the treatment of ankle osteoarthritis. Taiwan Journal of Physical Medicine and Rehabilitation. 2012; 40: 127-134.
33. Lin SH, Chu KA, Hsu CW, et al. Effects of repeated acupuncture on peak expiratory flow variation and serum eosinophil cationic protein concentration in asthmatic patients. Thoracic Medicine. 2013; 28: 138-146.
34. Chen YT, Hsu CW, Wu GS, Lai RS. The Effect of extracorporeal membrane oxygenation treatment on patients with severe acute respiratory distress syndrome caused by influenza virus. Thoracic Medicine. 2013; 28: 201-207.
35. Sun SH, Hsu CW, Lin HS, Sun HP, Chang PH, Hsieh WL, Wang JL. Combined neuromuscular electrical stimulation (NMES) with fiberoptic endoscopic evaluation of swallowing (FEES) and traditional swallowing rehabilitation in the treatment of stroke-related dysphagia. Dysphagia. 2013; 28: 557-566. doi: 10.1007/s00455-013-9466-9
36. Hsu CW, Sun SH, Lin HS, Lee DL, Chu KA. Clinical characteristics, hospital outcome and prognostic factors of patients with ventilator-related pneumothorax. Minerva Anestesiologica. 2014; 80(1): 29-38.
37. Hsu CW, Sun SH. Iatrogenic pneumothorax associated with mechanical ventilation. World Journal of Critical Care Medicine. 2014; 3(1): 8-14.
38. Sun SH, Hsu CW, Lin HS, Chou YJ, Chen JY, Wang JL. Efficacy of intraocular botulinum toxin A and intraarticular hyaluronate plus rehabilitation exercise in patients with unilateral ankle osteoarthritis: a randomized controlled trial. Journal of Foot and Ankle Research. 2014; 7(1): 9.
39. Hsu CW, Sun SH, Chu KA, Lee DL, Wong KF. Monitoring sedation for bronchoscopy in mechanically ventilated patients by using the Ramsay sedation scale versus auditory-evoked potentials. BMC Pulmonary Medicine. 2014; 14(1): 15. doi: 10.1186/1471-2466-14-15

Apostolia Hatziefthimiou, MD

Associate Professor of Medical Physiology
Laboratory of Physiology
Department of Medicine
School of Health Sciences
University of Thessaly
3 Panepistimiou Str
41500 BIOPOLIS Larissa, Greece

BiographyResearch InterestScientific ActivitiesPublications
EDUCATION

Graduate studies

• (1979-1985) Medical School, University of Patras, Greece, Degree 1985, grade “very good”


Postgraduate Studies

• (1987-1992) Specialization in Neurology
• (1992) Certificate of Neurology
• (1988-1995) Post graduate research fellow at the Department of Physiology, Medical School, University of Patras, Greece “Quantitative autoradiographic study of L-glutamate binding sites in human CNS”. Thesis Advisor: A. Mitsacos 1995 Doctorate, grade “excellent”
• (1/10/2007-31/3/2008) Training in cellular electrophysiology. Βoehringer-Ingelheim, Biberach,Germany. Advisor: Dr Draheim


PROFESSIONAL DATA

• (1986-1987) Mandatory service as General Practitioner at a rural state clinic
• (1987-1992) Specialization in Neurology, Clinical Practice for 6 months in Internal Medicine (General Hospital of Lymnos, Greece), for 6 months in Psychiatry (University Hospital of Patras, Greece) and for 3 years in Neurology (University Hospital of Patras, Greece)
• (1988-1992) Post graduate research fellow at the Department of Physiology, Medical School, University of Patras, Greece
• (1993-2000) Private practice, Neurologist, Volos
• (1995-2000) Adjunct Lecturer, Department of Physiology, Medical School, University of Thessaly, Greece
• (2000-2005) Lecturer, Laboratory of Physiology, Department of Medicine, School of Health Sciences, University of Thessaly Greece
• (2005-2013) Assistant Professor, Laboratory of Physiology, Department of Medicine, School of Health Sciences, University of Thessaly, Greece
• (2013-Present) Associate Professor, Laboratory of Physiology, Department of Medicine, School of Health Sciences, University of Thessaly, Greece

Her research interests include: Signal transduction – excitation contraction coupling, Smooth muscle cell proliferation, viability and phenotype, Regulation of hypoxia inducible factor (HIF-1) in smooth muscle cells and its role in ASM cell physiology, In vivo studies of heart and pulmonary function.

SUPERVISOR OF DOCTORATE THESIS


1. C. Daenas: “The effect of azithromycin on the responsiveness of airways smooth muscle to contractile agents.” Department of Physiology, Medical School, University of Thessaly. Completed in 2009.
2. R. Stamatiou: “Factors affecting the proliferation of airway smooth muscle.” Department of Physiology, Medical School, University of Thessaly. Completed in 2010.
3. E. Kitsiopoulou: “Factors affecting NO release in airways.” Department of Physiology, Medical School, University of Thessaly. Completed in 2012.

PUBLICATIONS IN PEER-REVIEWED JOURNALS


1. Hatziefthimiou A, Mitsacos A, Mitsaki E, Plaitakis A, Kouvelas ED. Quantitative autoradiographic study of L-glutamate binding sites in normal and atrophic human cerebellum. Journal of Neuroscience Research. 1991; 28(3): 367-375. doi: 10.1002/jnr.490280308
2. Hatziefthimiou A, Mitsacos A, Kouvelas ED. Autoradiographic characterization of the non-N-methyl-D-aspartate binding sites in human cerebellum using the antagonist [3H]6-cyano-7-nitroquinoxaline-2,3-dione. Journal of Neuroscience Research. 1994; 37(3): 392-397.
3. Gourgoulianis K, Iliodromitis Z, Hatziefthimiou A, Molyvdas PA. Epithelium-dependent regulation of airways smooth muscle function. A histamine-nitric oxide pathway. Mediators of Inflammation. 1998; 7(6): 409-411. doi: http://dx.doi.org/10.1080/09629359890785
4. Gourgoulianis KI, Chatziparasidis G, Chatziefthimiou A, Molyvdas PA. Intracellular action of magnesium in airways smooth muscle relaxation in rabbit. Applied Cardiopulmonary Pathophysiology. 1999; 8(1): 47-51. doi:
5. Gourgoulianis KI, Chatziparasidis G, Chatziefthimiou A, Molyvdas PA. Magnesium as a relaxing factor of airway smooth muscles. Journal of Aerosol Medicine: Deposition, Clearance, and Effects in the Lung. 2001; 14(3): 301-307. doi: 10.1089/089426801316970259
6. Hatziefthimiou AA, Gourgoulianis KI, Molyvdas PA. Epithelium-dependent effect of L-glutamate on airways: involvement of prostaglandins. Mediators of Inflammation. 2002; 11(1): 33-38. doi: http://dx.doi.org/10.1080/09629350210312
7. Chachami G, Simos G, Hatziefthimiou A, Bonanou S, Molyvdas PA, Paraskeva E. Cobalt induces hypoxia-inducible factor-1 alpha expression in airway smooth muscle cells by a reactive oxygen species-and P13K-dependent mechanism. American Journal of Respiratory Cellular and Molecular Biology. 2004; 31(5): 544-551. doi: 10.1165/rcmb.2003-0426OC
8. Hatziefthimiou AA, Karetsi E, Pratzoudis E, Gourgoulianis KI, Molyvdas PA. Resting tension effect on airway smooth muscle. The involvement of epithelium. Respiratory Physiology & Neurobiology. 2005; 145(2-3): 201-208. doi: 10.1016/j.resp.2004.06.004
9. Kouloumenta V, Hatziefthimiou A, Paraskeva E, Gourgoulianis K, Molyvdas PA. Non-genomic effect of testosterone on airway smooth muscle. British Journal of Pharmacology. 2006; 149(8): 1083-1091. doi:
10. Daenas C, Hatziefthimiou AA, Gourgoulianis KI, Molyvdas PA. Azithromycin has a direct relaxant effect on precontracted airway smooth muscle. European Journal of Pharmacology. 2006; 553(1-3): 280-287. doi: 10.1016/j.ejphar.2006.09.041
11. Papagianni Μ, Hatziefthimiou Α, Chachami G, Gourgoulianis Κ, Molyvdas PA, Paraskeva E. Insulin causes a transient induction of proliferation via activation of the PI3-kinase pathway in airway smooth muscle cells. Experimental and Clinical Endocrinology and Diabetes. 2007; 115(2): 118-123. doi: 10.1055/s-2007-967094
12. Chachami G, Hatziefthimiou A, Liakos P, et al. Exposure of differentiated airway smooth muscle cells to serum stimulates both induction of hypoxia-inducible factor-1α and airway responsiveness to ACh. American Journal of Physiology - Lung Cellular and Molecular Physiology. 2007; 293(4): L913-L922.
13. Stamatiou R, Paraskeva E, Boukas K, Gourgoulianis K, Molyvdas PA, Hatziefthimiou A. Azithromycin has an anti-proliferative and autophagic effect on airway smooth muscle cells. European Respiratory Journal. 2009; 34(3): 721-730.
14. Hatziefthimiou A, Kiritsi M, Kiropoulou C, Vasilaki A, Sakellaridis N, Molyvdas PA. Regional differences in the modulatory role of epithelium in sheep airways. Clinical and Experimental Pharmacology and Physiology. Clinical and Experimental Pharmacology and Physiology. 2009; 36(7): 668-674.
15. Stamatiou R, Boukas K, Paraskeva E, Molyvdas PA, Hatziefthimiou A. Azithromycin reduces viability of human bronchial smooth muscle cells. Journal of Antibiotics. 2010; 63(2): 71-75. doi: 10.1038/ja.2009.125
16. Xiromeritis AG, Hatziefthimiou AA, Hadjigeorgiou GM, Gourgoulianis KI, Anagnostopoulou DN, Angelopoulos NV. Quantitative spectral analysis of vigilance EEG in patients with obstructive sleep apnoea syndrome. Sleep and Breathing. 2011; 15(1): 121-128. doi: 10.1007/s11325-010-0335-6
17. Stamatiou R, Paraskeva E, Papagianni M, Molyvdas P-A, Hatziefthimiou A. The mitogenic effect of testosterone and 17β-estradiol on airway smooth muscle cells. Steroids. 2011; 76(4): 400-408. doi: 10.1016/j.steroids.2010.12.010
18. Stamatiou R, Petinaki E, Hatziefthimiou A. The effect of Panton Valentin Leukocidin (PVL) on the airway smooth muscle viability. Open Journal of Molecular and Integrative Physiology. 2013; 3: 42-47. doi: 10.4236/ojmip.2013.31007
19. Tsapournioti S, Mylonis I, Hatziefhimiou A, et al. TNFα induces expression of HIF-1α mRNA and protein but inhibits hypoxic stimulation of HIF-1 transcriptional activity in airway smooth muscle cells. Journal of Cellular Physiology. 2013; 228(8): 1745-1753. doi: 10.1002/jcp.24331
20. Hatziefthimiou A, Paschalis-Adam M, Efrosyni P. Physiological Parameters Affecting the Modulatory Role of Airway Epithelium on Airway Smooth Muscle Responsiveness. Pulm Res Respir Med Open J. 2014; 1(1): 1-8. 10.17140/PRRMOJ-1-101

Takeshi Saraya, MD, PhD

Assistant Professor
Department of Respiratory Medicine
Kyorin University School of Medicine
Mitaka City, Tokyo, Japan

BiographyResearch InterestScientific ActivitiesPublications
EDUCATION

• (March, 1998) Graduated from Juntendo University School of Medicine Awarded with MD
• (March, 1998) Awarded with Medical License
• (Sep, 2003) Board-certified member of the Japanese Society of Internal Medicine
• (Sep, 2006) Japanese boards in Infectious Diseases
• (Sep, 2006) Japanese boards in Respiratory Medicine
• (Sep, 2007) Japanese boards in a specialist of General Medicine
• (Sep, 2012) Awarded with PhD


PROFESSIONAL CAREER

• (May, 1998-Apr, 2000) Resident, Tokyo Metropolitan Hiroo Hospital
• (May, 2000-Apr, 2003) Resident, Tokyo Metropolitan Komagome Hospital
• (May, 2003-2013) Clinical Fellow, Department of Respiratory Medicine, Kyorin University School of Medicine
• (May, 2009-Present) Assistant Professor, Department of Respiratory Medicine


His clinical research is focused on Mycoplasma pneumoniae pneumonia, Tuberculouspleuritis virus infection and Respiratory diseases, Collagen vascular disease related interstitial pneumonia, and All the issues for educational value in General Medicine

MEMBERSHIPS


• (1998-Present): Japanese Society of Internal Medicine
• (2003-Present): Japanese Respiratory Society
• (2003-Present): Japanese Association for Infectious Disease
• (2010-Present): Japanese Society for Oriental Medicine
• (2010-Present): Japan Primary Care Association
• (2006-Present): The Japanese Society of Mycoplasmology
• (2013-Present): American Thoracic Society
• (2012-Present): American College of Chest Physicians
• (2016-Present): Member of Common Achievement Tests Organization for OSCE(Objective Structured Clinical Examination)
• (2016-Present): The International Organization for Mycoplasmology


AWARD


• (2016) Japan Chapter Award of American College of Chest Physician

1. Saraya T. The history of Mycoplasma pneumoniae pneumonia: Review. Front Microbiol. 2016; 7: 1-6. doi: 10.3389/fmicb.2016.00364
2. Hirukawa I, Saraya T, Wada S, Takizawa H. Marked enlargement of liver over a short period of time. Pulm Res Respir Med Open J. 2016; 3(1): 129. doi: 10.17140/PRRMOJ-3-123
3. Saraya T, Ishida M, Wada S, Fujiwara M, Takizawa H. Rapid diagnosis of hemosiderin-laden macrophages with diff-quick stain. Pulm Res Respir Med Open J. 2016; 2(4): 128. doi: 10.17140/PRRMOJ-3-122
4. Saraya T, Shimoda M, Hirata A, Takizawa H. Paradoxical respiration: “Seesaw” motion with massive pulmonary consolidation. BMJ Case Rep. 2016; 2016. doi: 10.1136/bcr-2015-213449
5. Saraya T. Clinical problem solving hidden disease with pulmonary alveolar hemorrhage. J Gen Fam Med. 2016; 17: 77-82.
6. Morimoto K, Saraya T, Kurosaki A, et al. Relapse of yellow nail syndrome with pulmonary lymphedema. Intern Med. 2016; 55(2): 169-172. doi: 10.2169/internalmedicine.55.4849
7. Nakamura M, Wada H, Honda K, et al. Clarithromycin ameliorates pulmonary inflammation induced by short term cigarette smoke exposure in mice. Pulm Pharmacol Ther. 2015; 35: 60-66. doi: 10.1016/j.pupt.2015.09.005
8. Honda K, Saraya T, Yokoyama T, Goto H, Takizawa H. Multiple mycotic hepatic and splenic artery aneurysms in a patient with pneumococcal pneumonia: A case report with a review of the literature. Clin Case Rep. 2015; 3(10): 891. doi: 10.1002/ccr3.369
9. Kimura H, Saitoh M, Kobayashi M, et al. Molecular evolution of haemagglutinin (H) gene in measles virus. 2015; 5: 11648. doi: 10.1038/srep11648
10. Saraya T, Kimura H, Takizawa H. Is mycoplasma pneumoniae infection associated with adult asthma exacerbation? Pulm Res Respir Med Open J. 2015; 2(3): 126-127. doi: 10.17140/PRRMOJ_2_121
11. Tsujimoto N, Saraya T, Richard W. Light, et al. A simple method for differentiating complicated parapneumonic effusion/empyema from parapneumonic effusion using the split pleura sign and the amount of pleural effusion on thoracic CT. PLoS One. 2015; 10(6): e0130141. doi: 10.1371/journal.pone.0130141
12. Saraya T, Nosaka T, Fujiwara M, et al. Pulmonary aspergillosis mimicking primary lung cancer. Pulm Res Respir Med Open J. 2015; 2(2): 75-76. doi: 10.17140/PRRMOJ-2-111
13. Saraya T, Takei H, Fujiwara M, et al. Primary pleural lymphoma with dense pleural thickening. Pulm Res Respir Med Open J. 2015; 2(2): 77-80. doi: 10.17140/PRRMOJ_2_112
14. Saraya T, Fujiwara M, Shimura C, Goto H. Not paraneoplastic pemphigus but pemphigus vulgaris in a patient with thymoma Editor s choice. BMJ Case Reports. 2015. doi: 10.1136/bcr-2015-210433
15. Saraya T, Tsujimoto N, Ohkuma K, Takizawa H. A Memory of World War II in a Japanese elderly man. Journal of General and Family Medicine. 2015; 16: 305-306. https://www.jstage.jst.go.jp/article/jgfm/16/4/16_305/_pdf
16. Saraya T, Ohara M. Identification of Cryoglobulin deposition on electron microscope. Journal of General and Family Medicine. 2015; 16: 303-304. https://www.jstage.jst.go.jp/article/jgfm/16/4/16_303/_pdf
17. Saraya T. Pulmonary Aspergillosis Mimicking Primary Lung Cancer. Pulm Res Respir Med Open J. 2015; 2(2): 75-76.
18. Yanagihara K, Kadota J, Aoki N, Saraya T, Fujita M. Nationwide surveillance of bacterial respiratory pathogens conducted by the surveillance committee of Japanese Society of Chemotherapy, the Japanese Association for Infectious Diseases, and the Japanese Society for Clinical Microbiology in 2010: General view of the pathogens antibacterial susceptibility. J Infect Chemother. 2015; 21(6): 410-420. doi: 10.1016/j.jiac.2015.02.008
19. Shimoda M, Saraya T. Dumping syndrome by misplacement of gastrostomy feeding tube. Intern Med. 2015; 54(19): 2529.
20. Saraya T, Ariga M, Takahashi M, Tanabe E. Othello Pica: clue of recurrent rectal cancer. Intern Med. 2015; 54(19): 2525. doi: 10.2169/internalmedicine.54.5062
21. Saraya T, Matsuoka R, Tsujimoto N, Takizawa H. Yellow Nail Syndrome in Toenails. Intern Med. 2015; 54: 2089. doi: 10.2169/internalmedicine.54.4875
22. Ohkuma K, Saraya T, Tsujimoto N, Takizawa H. Massive barium sulfate aspiration in the bronchial tree. Intern Med. 2015; 54: 2081. doi: 10.2169/internalmedicine.54.4829
23. Tsujimoto N, Saraya T, Nunokawa H, Ohkuma K, Goto H, Takizawa H. Flapping tremor as a diagnostic tool for evaluation of hypercapnia. Pulm Res Respir Med Open J. 2015; 2(1): 49-51. doi: 10.17140/PRRMOJ-2-107
24. Saraya T, Kikuchi K, Araki K, et al. Reversed halo sign caused by huge tricuspid native valve infective endocarditis associated with community-acquired methicillin-resistant Staphylococcus aureus. JMMCR. 2015. http://www.microbiologyresearch.org/docserver/fulltext/jmmcr/2/1/jmmcr001628.pdf?expires=1466153858&id=id&accname=guest&checksum=5D19B7FE37199BAA7693F76497207DB4
25. Saraya T, Sada M, Ohkuma K, et al.Evidence of unilateral metastatic pulmonary calcifications with prolonged fever and arthralgia caused by acute lymphoblastic leukemia in a chronic dialysis patient. Intern Med. 2015; 54: 63-67. doi: 10.2169/internalmedicine.54.2840
26. Saraya T, Takizawa H. Evidence of pulmonary disseminated cryptococcosis: Diffuse multiple micronodules on thoracic CT. Am J Med. 2015; 128(1): e21.
27. Saraya T, Takizawa H. Rothia aeria: A great mimicker for Nocardia species. BMJ Case Rep. 2014; 2014. http://www.unboundmedicine.com/medline/citation/25553634/Evidence_of_pulmonary_disseminated_cryptococcosis:_diffuse_multiple_micronodules_on_thoracic_computed_tomography_
28. Toriumi S, Saraya T, Tsujimoto N, et al. Renal Salt Wasting Syndrome due to Carboplatin in a Patient with Lung Cancer. Pulm Res Respir Med Open J. 2014; 1(1): 9-12. doi: 10.17140/PRRMOJ-1-102
29. Tanaka Y, Saraya T, et al. Spontaneous resolution of Pneumocystis jirovecii pneumonia on high resolution computed tomography in a patient with renal cell carcinoma. Am J Case Rep. 2014; 15: 496-500. doi: 10.12659/AJCR.890947
30. Tsujimoto SI, Tsukagoshi H, Inai I, et al. Apnea, dyspnea, and wheezing in primary lower respiratory infections due to human rhinovirus in Japanese infants. JMMCR. 2014. doi: 10.1099/jmmcr.0.002113
31. Saraya T, Kurai D, Nakagaki K, et al. Novel aspects on the pathogenesis of Mycoplasma pneumoniae pneumonia and therapeutic implications Front. Microbiol. 2014. doi: 10.3389/fmicb.2014.00410
32. Saraya T, Watanabe T, Tsujimoto N, et al. Case of candidemia with Candida glabrata with confirmation of the acquistion of micafungin sensitivity due to new mutation of FKS gene mutation . Kansenshogaku Zasshi. 2014; 88: 1-5.
33. Tsujimoto N, Saraya T, Shimoda M, Goto H. Three stripes sign: muscle involvement with internal fibrosis in a patient with sarcoidosis. BMJ Case Rep. 2014. doi: 0.1136/bcr-2014-204691
34. Sohara E, Saraya T, Sato S, et al. Mechanics hands revisited: Is this sign still useful for diagnosis in patients with lung involvement of collagen vascular diseases. BMC Research Notes. 2014; 7: 303. doi: 10.1186/1756-0500-7-303
35. Saraya T, Kurai D, Ishii H, et al. Epidemiology of virus-induced asthma exacerbations: with special reference to the role of human rhinovirus Front. Microbiol. 2014. doi: 10.3389/fmicb.2014.00226
36. Saraya T, Tanabe K, Araki K, et al. Breakthrough invasive Candida glabrata in patients on micafungin: A novel FKS gene conversion correlated with sequential elevation of minimum inhibitory concentration. J Clin Microbiol. 2014; 52(7): 2709-2712. doi: 10.1128/JCM.03593-13
37. Tsuji S, Saraya T, Tanaka Y, et al. Community-acquired Pseudomonas aeruginosa pneumonia in previously healthy patients. JMM Case Rep. 2014. doi: 10.1099/jmmcr.0.000281
38. Ishii H, Seymour JF, Tazawa R, et al. Secondary pulmonary alveolar proteinosis complicating myelodysplastic syndrome results in worsening of prognosis: a retrospective cohort study in Japan. BMC Pulm Med. 2014; 14(1): 37. doi: 10.1186/1471-2466-14-37
39. Sada M, Saraya T, Ishii H, et al. Sudden multiple fractures in a patient with sarcoidosis in multiple organ. BMJ Case Rep. 2014. doi: 10.1136/bcr-2013-201408
40. Nishizawa T, Saraya T, Ishii H, Goto H. Antemortem diagnosis with multiple random skin biopsies and transbronchial lung biopsy in a patient with intravascular large B cell lymphoma, so-called Asian variant lymphoma. BMJ Case Rep. 2014. doi: 10.1136/bcr-2013-202661
41. Shimoda M, Saraya T, Tsujimoto N, Kurai D, Takizawa H, Goto H. Fatal disseminated cryptococcosis resembling miliary tuberculosis in a patient with HIV infection. Intern Med. 2014. doi: http://dx.doi.org/10.2169/internalmedicine.53.2005
42. Ogawa Y, Saraya T, Koide T, et al. Methicillin-resistant Staphylococcus aureus enterocolitis sequentially complicated with septic arthritis: a case report and review of the literature. BMC Research Notes. 2014; 7: 21 doi: 10.1186/1756-0500-7-21
43. Saraya T, Suzuki T, Goto H. Fecal leukocyte in the diagnosis of ulcerative colitis Braz. J Infect Dis. 2013. doi: 10.1016/j.bjid.2013.07.008
44. Saraya T, Light RW, Takizawa H, Goto H. Black Pleural Effusion. Am J Med. 2013; 126: e1-e6. doi: 10.1016/j.amjmed.2012.11.017
45. Saraya T, Light RW, Takizawa H, Goto H. Black Pleural Effusion: Author reply. 2013; 126(12): e21. doi: 10.1016/j.amjmed.2012.11.017
46. Kurai D, Saraya T, Ishii H, Takizawa H. Virus-induced exacerbations in asthma and COPD Front. Microbiol. 2013. doi: 10.3389/fmicb.2013.00293
47. Nakajima A, Saraya T, Mori T, et al. Familial summer-type hypersensitivity pneumonitis in Japan: Two case reports and review of the literature. BMC Res Notes. 2013; 6(1): 371. doi: 10.1186/1756-0500-6-371
48. Saraya T, Ariga M, Kato A, Goto H. Non-syndromic Brachydactyly named Shamoji-yubi or Mamushi-yubi in Japan. BMJ Case Rep. 2013. doi: 10.1136/bcr-2013-201242
49. Ohkuma K, Saraya T, Sada M, Kawai S. Evidence for cytomegalovirus-induced hemophagocytic syndrome in a young patient with acquired immune deficiency syndrome. BMJ Case Rep. 2013. doi: http://dx.doi.org/10.1136/bcr-2013-200983
50. Oda M, Saraya T, Wakayama M, et al. Calcium oxalate crystal deposition in a patient with Aspergilloma due to Aspergillus niger. J Thorac Dis. 2013; 5(4): E174-E178. doi: 10.3978/j.issn.2072-1439.2013.08.45
51. Saraya T. Establishment of a novel mouse model for Mycoplasma pneumoniae pneumonia. Jpn J Mycoplasmology. 2013; 40: 34-38.
52. Saraya T, Takata S, Fujiwara M, Takei H. Cellular non-specific interstitial pneumonia masquerading as congestive heart failure. BMJ Case Rep. 2013. doi: 10.1136/bcr-2013-010502
53. Saraya T, Ohkuma K, Hirata A, Nakamoto K. Phantom tumor of the lung. BMJ Case Rep. 2013. doi: 10.1136/bcr-2013-010457
54. Saraya T, Ariga M, Takizawa h, Goto H. Late-occurring paradoxical reaction masquerading as treatment failure of tuberculous adenitis. Intern Med. 2013; 52(20): 2385-2386. doi: http://dx.doi.org/10.2169/internalmedicine.52.0826
55. Sada M, Saraya T, Tanaka Y, et al. A case of invasive tracheobronchial aspergillosis in a patient with systemic lupus erythematosus-dermatomyositis overlapped syndrome. Intern Med. 2013; 52(18): 2149-2153. doi: http://dx.doi.org/10.2169/internalmedicine.52.0419
56. Saraya T, et al. Massive myocardical abscesses caused by Methicillin-susceptible Staphylococcus aureus. Intern Med. 2013; 52(17): 1999. doi: http://dx.doi.org/10.2169/internalmedicine.52.0852
57. Higaki M, Kurai D, Ito A, Saraya T. Hypohydrosis as clinical clue to diagnosis of Horners syndrome. BMJ Case Rep. 2013. doi: 10.1136/bcr-2013-009732
Intern Med. 2013; 52(15): 1757-1758. doi: http://dx.doi.org/10.2169/internalmedicine.52.0660
59. Kushibuchi I, Kobayashi M, Kusaka T, et al. Molecular evolution of attachment glycoprotein (G) gene in human respiratory syncytial virus detected in Japan 2008-2011. Infect Genet Evol. 2013; 24; 18C: 168-173. doi: 10.1016/j.meegid.2013.05.010
60. Saraya T, Mikoshiba M, Kamiyama H, et al. Evidence for reactivation of human herpes virus 6 in generalized lymphadenopathy in a patient with drug induced hypersensitivity syndrome. J. Clin. Microbiol. 2013; 51(6): 1979-1982. doi: 10.1128/JCM.00097-13
61. Nagatomo T, Saraya T, et al. Sudden Hemoptysis in a patient with Bronchial Schwannoma complicated with pulmonary embolism. General Medicine. 2013; 14(1): 67-71.
62. Saraya T, Inoue M, Takizawa H, Goto H. Varicella-Zoster Virus Pneumonia in an Immunocompetent Patient. Intern Med. 2013; 52(9): 1003. doi: http://dx.doi.org/10.2169/internalmedicine.52.0150
63. Tsujimoto N, Saraya T, Takizawa H, Goto H. Tuberculous Peritonitis Incidentally Diagnosed on FDG-PET/CT. Intern Med. 2013; 52: 841-842. doi: http://dx.doi.org/10.2169/internalmedicine.52.9197
64. Nagatomo T, Saraya T. Re: Two cases of bilateral bronchial artery varices: one with and one without bilateral coronary-to-pulmonary artery fistulas. Review and characterization of the clinical features of bronchial artery varices reported in Japan. A reply Clin Radiol. 2013. doi: 10.1016/j.crad.2013.01.015
65. Saraya T, Ohkuma K, Kikuchi K, et al. Cytomegalovirus pneumonia in a patient with interstitial pneumonia and Nocardia asiatica presenting as cavitary lung lesions. Intern Med. 2013; 52: 593-597. doi: http://dx.doi.org/10.2169/internalmedicine.52.8627
66. Saraya T, Fujino T, Suzuki A, et al. Hodgkin lymphoma with rapidly destructive, cavity-forming, lung disease. J Clin Oncol. 2013; 31(12): e211-214. doi: 10.1200/JCO.2012.45.5089
67. Tamura M, Saraya T, Fujiwara M, et al. High-Resolution CT Findings in Cases with Drug-Induced Pulmonary Toxicity with Special Reference to Hypersensitivity Pneumonitis-Like Patterns in Gemcitabine-Induced Cases. Oncologist. 2013; 18(4): 454-459. doi: 10.1634/theoncologist.2012-0248
68. Saraya T, Yokoyama T, Ishii H, et al. A case of malignant peritoneal mesothelioma revealed with limitation of PET-CT in the diagnosis of thoracic metastasis. Journal of Thoracic Disease. 2013; 5: E11-E16. doi: 10.3978/j.issn.2072-1439.2012.08.19
69. Saraya T, Tanaka R, Fujiwara M, et al. Fluorodeoxyglucose (FDG) uptake in pulmonary rheumatoid nodules diagnosed by video-assisted thoracic surgery lung biopsy: two case reports and a review of the literature. Mod Rheumatol. 2013; 23(2): 393-396. doi: 10.1007/s10165-012-0664-3
70. Kurai D, Nakagaki K, Wada H, et al. Mycoplasma pneumoniae Extract Induces an IL-17-Associated Inflammatory Reaction in Murine Lung: Implication for Mycoplasmal Pneumonia. Inflammation. 2013 ; 36(2): 285-293. doi: 10.1007/s10753-012-9545-3
71. Tsujimoto N, Saraya T, Kikuchi K, et al. High-resolution CT findings of patients with pulmonary nocardiosis. J Thorac Dis. 2012; 4(6): 577-582. doi: 10.3978/j.issn.2072-1439.2012.11.07
72. Sohara E, Saraya T, Honda K, et al. Guillain-Barré syndrome in two patients with respiratory failure and a review of the Japanese literature. J Thorac Dis. 2012; 4(6): 601-607. doi: 10.3978/j.issn.2072-1439.2012.11.01
73. Kurai D, Saraya T, et al. Potts disease. General Medicine. 2012; 13: 110-112. doi:
74. Hirukawa I, Saraya T, Tanaka R, et al. Pulmonary actinomycosis diagnosed by video-assisted thoracic surgery with a growing fungus ball within a small cavity. Nihon Kokyuki Gakkai Zasshi. 2012; 1(6). doi:
75. Nakajima A, Saraya T, Takata S, et al. The saw-tooth sign as a clinical clue for intrathoracic central airway obstruction. BMC Research Notes. 2012; 5: 388. doi: 10.1186/1756-0500-5-388
76. Nagatomo T, Saraya T, Masuda Y, et al. Two cases of bilateral bronchial artery varices: One with and one without bilateral coronary-to-pulmonary artery fistulas. Review and characterization of the clinical features of bronchial artery varices reported in Japan. Clin Radiol. 2012. doi: 10.1016/j.crad.2012.04.012
77. Saraya T, Shimoda M, Tanaka Y, et al. Use of morphological evaluation using Ziehl-Neelsen stain for diagnosis of Mycobacterium kansasii. General Medicine. 2012; 13: 53-54. doi: http://dx.doi.org/10.14442/general.13.53
78. Saraya T, Tanaka Y, Ohkuma K, et al. Massive tension pneumomediastinum. Intern Med . 2012; 51: 677. doi: http://dx.doi.org/10.2169/internalmedicine.51.6903
79. Koide T, Saraya T, Nakajima A, et al. A 54-year-old man with an uncommon cause of left pleural effusion. CHEST. 2012; 141(2): 560-563. doi: 10.1378/chest.11-1493
80. Yanagihara K, Matsumoto T, Saraya T, et al. Nationwide surveillance of bacterial respiratory pathogens conducted by the Surveillance Committee of Japanese Society of Chemotherapy, Japanese Association for Infectious Diseases, and Japanese Society for Clinical Microbiology in 2009: general view of the pathogens antibacterial susceptibility. J Infect Chemother. 2012. doi: 10.1007/s10156-012-0434-3
81. Saraya T, Nakata K, Nakagaki K, et al. Identification of a mechanism for lung inflammation caused by Mycoplasma pneumoniae using a novel mouse model. Results in Immunology. 2011; 1: 76-87. doi: 10.1016/j.rinim.2011.11.001
82. Honda K, Saraya T, Tamura M, et al. Tumor lysis syndrome and acquired ichthyosis occurring after chemotherapy for lung adenocarcinoma. J Clin Oncol. 2011; 29: e859-e860. doi: 10.1200/JCO.2011.36.8175
83. Koide T, Saraya T, Nakamoto K, et al. A case of imatinib mesylate-induced pneumonitis based on the detection of epithelioid granulomas by video-assisted thoracoscopic surgery biopsy in a patient with chronic myeloid leukemia. Nihon Kokyuki Gakkai Zasshi. 2011; 49(6): 465-471.
Eur Respir J. 2011; 37(2): 465-468. doi: 10.1183/09031936.00092910
85. Niki Y, Hanaki H, Matsumoto T, et al. Nationwide surveillance of bacterial respiratory pathogens conducted by the Japanese Society of Chemotherapy in 2008: general view of the pathogens antibacterial susceptibility. J Infect Chemother. 2011; 17(4): 510-523. doi: 10.1007/s10156-011-0214-5
86. Hirao S, Wada H, Saraya T, et al. Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone. FEMS Immunol Med Microbiol. 2011; 62(2): 182-189. doi: 10.1111/j.1574-695X.2011.00799.x
87. Takata S, Wada H, Saraya T, et al. Kinetics of c-reactive protein (CRP) and serum amyloid A protein (SAA) in patients with community-acquired pneumonia (CAP), as presented with biologic half-life times. Biomarkers. 2011. doi: 10.3109/1354750X.2011.607189
88. Nagel MA, Cohrs RJ, Saraya T, et al. The varicella zoster virus vasculopathies: clinical, CSF, imaging, and virologic features. Neurology. 2008; 70(11): 853-860. doi: 10.1212/01.wnl.0000304747.38502.e8
89. Saraya T, et al. Study of immunomodulatory effects of Clarithromycin against the mycoplasma pneumonia mouse model. Jpn J Antibiotics. 2008; 61: 9-12.
90. Saraya T, Shimura C, Mikura S, et al. Huge mediastinal mass with SVC syndrome accompanying numerous chest wall collateral vessels. Intern Med. 2008; 47(19): 1719-1712. doi: http://dx.doi.org/10.2169/internalmedicine.47.1076
91. Saraya T, Ariga M, Kurai D, Takeshita N, Honda K, Goto H. Terrys nails as a part of aging. Intern Med. 2008; 47(6): 567-568. doi: http://dx.doi.org/10.2169/internalmedicine.47.0788
92. Shimura C , Saraya T, Wada H, et al. Pathological evidence of rhabdomyolysis-induced acute tubulointerstitial nephritis accompanying Legionella pneumophila pneumonia. J Clin Pathol. 2008; 61(9): 1062-1063. doi: 10.1136/jcp.2008.057000
93. Saraya T, Kurai D, Ariga M, et al. Superior mesenteric artery syndrome caused by huge mycotic abdominal aortic aneurysm. Intern Med. 2009; 48(12): 1065-1068. doi: http://dx.doi.org/10.2169/internalmedicine.48.1684
94. Saraya T, Shimura C, Kato A, et al. Pulmonary sarcoidosis with massive parenchymal masses. Intern Med. 2007; 46(23): 1939-1940.
95. Saraya T, Shimura C, Wada H, Aoshima M, Goto H. Evidence for vascular spread of varicella zoster-associated vasculopathy. Ann Intern Med. 2006; 144(7): 535-537.

Rodopi Stamatiou, PhD

Department of Physiology
Medical School
University of Thessaly, Greece

BiographyResearch InterestScientific ActivitiesPublications
2010-today:

Post doctorate researcher in the Department of Physiology, Medical School, University of Thessaly, Larissa, Greece.


September 2010-December 2013:

Participation in the master thesis research project of Ms. Gianni Eleni, post graduate student in the Department of Physiology, Medical School, University of Thessaly, Larissa, Greece, “The effect of muscarinic agonists on the phenotype of human bronchial smooth muscle cells”. Participation in the master thesis research project of Ms. Salatai Eralda, post graduate student in the Department of Physiology, Medical School, University of Thessaly, Larissa, Greece, “The combined effect of TGF and sex hormones on the proliferation of airway smooth muscle cells”.


April 2009-August 2009:

Research program “Study of the effect of muscarinic receptors on the proliferation of airway smooth muscle cells”. Department of Physiology, Medical School, University of Thessaly, Larissa, Greece.


January 2008-December 2008:

Program for the reformation of the graduate studies of Medicine students “Biological applications in experimental arrays”. Department of Physiology, Medical School, University of Thessaly, Larissa, Greece.


January 2006-July 2006:

Program for the reformation of the graduate studies of Medicine students “Biological applications in experimental arrays”. Department of Physiology, Medical School, University of Thessaly, Larissa, Greece.


May 2006 – March 2010:

PhD thesis research program “Factors that affect the proliferation of cells of the respiratory system”. Department of Physiology, Medical School, University of Thessaly, Larissa, Greece.


2006:

Participation in the master thesis research project of Ms. Boutoureli Christina, post graduate student in the School of Biochemistry and Biotechnology, University of Thessaly, Larissa, Greece, “The effect of growth factors on cell signalling in airway smooth muscle cells”.


2006:

Participation in the experimental lessons of “Membrane Biophysics” of the postgraduate program “Clinical applications of Molecular Medicine” of the Medical School, School of Health Sciences, University of Thessaly.


September 2004-July 2006:

Acquisition, statistical analysis of data and participation in experimental procedures in the Pythagoras Research program “The effect of insoulin in airway smooth muscle cells”. Department of Physiology, Medical School, University of Thessaly, Larissa, Greece.


September 2002 – June 2003:

Graduate thesis research project “The effect of pollution on intracellular mechanisms of cell signaling in gonad cells of the Mytilus galloprovincialis mollusk”. Laboratory of Animal Physiology, Biology Department, School of Science, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Her research interests include: Smooth muscle cells, cardiac myocytes, arrhythmias, cell signalling, molecular mechanisms, cell proliferation, phenotype markers, growth factors, cytokines, and hormones.

SEMINARS- CONFERENCES

March 2013:

2nd Scientific Meeting of Physiology Laboratories. Hellenic Physiology Society, Department of Physiology, Medical School, School of Health Sciences, Aristotle University of Thessaloniki.
Presentation: “The effect of muscarinic receptor agonists on the phenotype of airway smooth muscle cells”.


October 2012:

HypoxiaNet Meeting “Sensing Hypoxia in the cell and the organism”. Essen, Germany.
Presentation: “TNFα induces HIF-1α mRNA and protein via NF-κB but inhibits hypoxic HIF-1α/ARNT complex formation and HRE-dependent transcriptional activity in Airway Smooth Muscle Cells”.
S. Tsapournioti, I. Mylonis, A. Hatziefthimiou, M. Ioannou, R. Stamatiou, G. Koukoulis, G. Simos, P.A. Molyvdas and E. Paraskeva.


September 2011:

Turkish-FEPS Congress.
Presentation: “The effect of muscarinic receptors agonists on airway smooth muscle cell proliferation and phenotype”.
Apostolia Hatziefthimiou, Rodopi Stamatiou, Efrosini Paraskeva, Eleni Gianni, Konstantinos Gourgoulianis, Paschalis Adam Molyvdas “Induction of airway smooth muscle proliferation by TGF and bFGF: the effect of sex hormones”.
Apostolia Hatziefthimiou, Rodopi Stamatiou, Efrosini Paraskeva, Anta Salatai, Konstantinos Gourgoulianis, Paschalis Adam Molyvdas


November 2011:

20th Congress of Thoracic Diseases (Athens, Greece).
Presentation: “The effect of PANTON-VALENTIN leukocidin (PVL) on airway smooth muscle cells.” Rodopi Stamatiou, Euthimia Petinaki, Apostolia Hatzieuthmiou.


May 2010:

1st Scientific Meeting of Physiology Laboratories. Hellenic Physiology Society, Department of Physiology, Medical School, School of Health Sciences, University of Thessaly.


November 2009:

18th Congress of Thoracic Diseases (Thessaloniki, Greece).
Presentation: “Azithromycin reduces the viability of human bronchial smooth muscle cells”. Stamatiou R., Boukas K., Paraskeva E., Molyvdas PA., Hatzieuthimiou A.


April 2009:

Meeting of the Hellenic Society of Biochemistry and Molecular Biology. “Cell communication and signaling”. Aristotle University of Thessaloniki.


November 2008:

17th Congress of Thoracic Diseases (Alexandroupoli, Greece).
Presentation: “Azithromycin induces autophagy in airway smooth muscle cells”. Stamatiou R., Paraskeva E., Gourgoulianis K., Molyvdas PA., Hatzieuthimiou A.


December 2007:

16th Congress of Thoracic Diseases (Athens, Greece).
Presentation: “Azithromycin reduces the proliferation of airway smooth muscle cells”. Stamatiou R., Paraskeva E., Gurgoulianis K., Molyvdas PA., Hatzieuthimiou A.
“Testosterone induces proliferation in airway smooth muscle cells”. Stamatiou R., Paraskeva E., Papagianni M., Molyvdas PA., Hatzieuthimiou A.


December 2007:

“Statistic analysis of Medical data with SPSS”. Seminar, Biomathematics Department, Medical School, School of Health Sciences, University of Thessaly.


2006-2007:

Lectures of the postgraduate program “Clinical applications of Molecular Medicine” of the Medical School, School of Health Sciences, University of Thessaly.


September 2006:

“Pneumonology Days”, Hellenic Pneumonology Society, Department of Respiratory Medicine, University Hospital, University of Thessaly. Larissa.
Presentation: “The effect of sex hormones in airway remodeling”. R. Stamatiou


April 2006:

Working seminars “Methodology of Research”. Hellenic Society of Social Medicine.


CURRENT SCIENTIFIC PROJECTS-INTERESTS

From 2012 to today I have been working in the following research projects:
Research of the effect of muscarinic antagonists on airway smooth muscle cells. Specifically, this study contains of experiments that are aiming to elucidate the mechanisms through which muscarinic agonists are affecting the airway smooth muscle cell proliferation, signaling as well as the presence of muscarinic receptors on the cell membrane.
Research of the toxicity of Panton Valentin Leucocidin, acquired from MRSA infections, as well as of the mechanisms of the toxin action on airway smooth muscle cells.
Research of the subcellular electrophysiologic mechanisms elucidating the cardiac proarrhythmic effects of macrolide antibiotics in normal and ischemic rabbit hearts. Specifically, this study contains a part of in vitro experiments in anesthetised rabbits and documentation of MAP dynamics, and a part of experiments that are conducted on isolated cardiac myocytes and contains the study of cell signalling pathways that are activated by macrolide antibiotics.
Member of the editorial board of Annals of Vascular medicine and research Journal. Member of the Hellenic Physiology Society.

SCIENTIFIC PUBLICATIONS


1. Stamatiou R, Paraskeva E, Vasilaki A, et al. Long-term exposure to muscarinic agonists decreases expression of contractile proteins and responsiveness of rabbit tracheal smooth muscle cells. BMC Pulmonary Medicine. 2014; 14: 39. doi: 10.1186/1471-2466-14-39
2. Stamatiou R, Petinaki E, Hatziefthimiou A. The effect of Panton-Valentin leukocidin (PVL) on the airway smooth muscle. Open Journal of Molecular and Integrative Physiology. 2013; 3: 42-47. doi: 10.4236/ojmip.2013.31007
3. Tsapournioti S, Hatziefhimiou A, Loannou MG, et al. Crosstalk between inflammation and hypoxia in the airways: TNFα induces HIF-1α protein and mRNA in Airway Smooth Muscle Cells via an NF-κB/ROS dependent pathway, but inhibits HRE-dependent transcriptional activity under hypoxia. J. Cell. Physiol. 2013; 228: 1745-1753. doi:
4. Stamatiou R, Paraskeva E, Gourgoulianis K, Molyvdas PA, Hatziefthimiou A. Cytokines and Growth Factors Promote Airway SmoothMuscle Cell Proliferation. ISRN Inflammation. 2012. doi: http://dx.doi.org/10.5402/2012/731472
5. Apostolia H, Stamatiou R, Efrosini P, et al. Induction of airway smooth muscle proliferation by TGF and bFGF: the effect of sex hormones. Acta Physiologica. 2011; 203(686). doi:
6. Apostolia H, Stamatiou R, Efrosini P, et al. The effect of muscarinic receptors agonists on airway smooth muscle cell proliferation and phenotype. Acta Physiologica. 2011; 203(686).
7. Stamatiou R, Paraskeva E, Papagianni M, Molyvdas P-A, Hatziefthimiou A. The mitogenic effect of testosterone and 17β-estradiol on airway smooth muscle cells. Steroids. 2011; 76: 400-408. doi: 10.1016/j.steroids.2010.12.010
8. Stamatiou R, Boukas K, Paraskeva E, Molyvdas PA, Hatziefthimiou A. Azithromycin reduces the viability of human bronchial smooth muscle cells. Journal of Antibiotics. 2010; 63: 71-75. doi: 10.1038/ja.2009.125
9. Stamatiou R, Paraskeva E, Boukas K, Gourgoulianis KI, Molyvdas PA, Hatziefthimiou A. Azithromycin has an anti-proliferative and autophagic effect on airway smooth muscle cells. European Respiratory Journal. 2009; 34: 721-730. doi: 10.1183/09031936.00089407
10. Kaloyanni M, Stamatiou R, Dailianis S. Zinc and 17β-estradiol induce modifications in Na+ /H+ exchanger and pyruvate kinase activity through protein kinase C in isolated mantle/gonad cells of Mytilus galloprovincialis. Comparative Biochemistry and Physiology, Toxicol Pharmacol C. 2005; 141: 257-266.

Aylin Ozsancak, MD

Assistant Professor of Pulmonary Medicine
Baskent University
Oymaci sok No 2
34662 Altunizad, Istanbul, Turkey

BiographyResearch InterestScientific ActivitiesPublications
EDUCATIONAL QUALIFICATIONS

• (2011-Present) Assistant Professor of Pulmonary Medicine, Pulmonary Medicine Department, Baskent University, Istanbul, TURKEY.
• (2009-2011) Teaching Assistant, Pulmonary Medicine Depatment, Baskent University, TURKEY
• (2008-2009) Sleep Medicine Fellowship, Pulmonary, Critical Care and Sleep Division, Tufts Medical Center, Boston, MA, USA.
• (2008) ECFMG (Education Committee for Foreign Medical Graduates) Certificate, USA.
• (2006-2008) Research Fellowship, Pulmonary, Critical Care and Sleep Division, Tufts Medical Center, Boston, MA, USA.
• (2005)Specialist Degree, Department of Pulmonary Diseases, Baskent University, Ankara, Turkey.
• (2000) M.D., School of Medicine (Education in English), Hacettepe University, Ankara, Turkey.


PROFESSIONAL EXPERIENCES

• (2011-Present) Assistant Professor of Pulmonary Medicine, Pulmonary Medicine Department, Baskent University, Istanbul, Turkey.
• (2010-2011) Teaching Assistant as a Chest Physician, Pulmonary Medicine Department, Baskent University, Istanbul, Turkey.
• (2009-Present) Coordinator of Sleep Laboratories, Pulmonary Medicine Department, Baskent University, Turkey.
• (2009-2010) Teaching Assistant as a Chest Physician, Pulmonary Medicine Department, Baskent University, Adana, Turkey..
• (2008-2009) Sleep Medicine Fellow; Pulmonary, Critical Care and Sleep Division, Tufts Medical Center, Boston, MA, USA.
• (2006-2008) Postdoctoral Research Fellow; Pulmonary, Critical Care and Sleep Division, Tufts-NEMC, Boston, MA, USA.
• (2005-2005) Chest Physician; Department of Pulmonary Diseases, Baskent University, Ankara, Turkey.
• (2004-2005) Observer; Pulmonary, Critical Care and Sleep Division, Tufts Medical Center, Boston, MA, USA.
• (2000-2005) Resident; Department of Pulmonary Diseases, Baskent University, Ankara, Turkey.

Her research interests include: Noninvasive mechanical ventilation, Sleep medicine, Pulmonary rehabilitation.

MEMBERSHIPS

• Turkish Thoracic Society
• American Thoracic Society
• European Respiratory Society
• Turkish Sleep Medicine Society

1. Ozyilmaz E, Ugurlu AO, Nava S. Timing of noninvasive ventilation failure: causes, risk factors, and potential remedies. BMC Pulm Med. 2014; 14: 19. doi: 10.1186/1471-2466-14-19
2. Ugurlu AO, Sidhom SS, Khodabandeh A, et al. Use and Outcomes of Noninvasive Positive Pressure Ventilation in Acute Care Hospitals in Massachusetts. Chest. 2014. doi: 10.1378/chest.13-1707
3. Ozsancak A. The location of noninvasive mechanical ventilation application: Emergency department, wards, intensive care unit. Güncel Göğüs Hastalıkları Serisi. 2013; 1(2): 38-54.
4. Habesoglu MA, Ozsancak Ugurlu A, Oner Eyüboglu F. Clinical, Radiologic, and Functional Evaluation of 304 Patients with Bronchiectasis. Annals of Thoracic Medicine. 2011; 6(3): 131-136.
5. Ozsancak A, Sidhom S, Liesching T, Howard W, Hill NS. Evaluation of the Total Face Mask for Noninvasive Ventilation to Treat Acute Respiratory Failure. Chest. 2011; 139(5): 1034-1041. doi: 10.1378/chest.10-1905
6. Ozsancak A, DAmbrosio C, Garpestad E, Schumaker G, Hill NS. Sleep and Mechanical Ventilation. Crit Care Clin. 2008; 24: 517-531. doi: 10.1016/j.ccc.2008.03.002
7. Ozsancak A, DAmbrosio C, Hill NS. Nocturnal Noninvasive Ventilation. Chest. 2008; 133: 1275-1286. doi: 10.1378/chest.07-1527
8. Atar A, Özsancak A, Gülmez Ö, et al. Dalgası Dispersiyonunun Normal Populasyon ile Karşılaştırılması. TAPE. 2008; 6: 44-48.
9. Savas Bozbas S, Akcay S, Kivanc T, Ozsancak A, Oner Eyuboglu F. The Effectiveness of Thrombolytic Therapy in Patients with Massive and Submassive Pulmonary Thromboembolism. Tuberk Toraks. 2007; 55: 34-42.
10. Ozsancak A, Akcay S, Basaran O, et al. Pulmonary Complications in Burn Patients. Dialysis, Transplantation and Burns. 2006; 17: 52-57.
11. Ozsancak A, Akcay S, Oner-Eyuboglu F, Aydin G, Colak M. Retrospective Analysis of Bronchoprovocation Test Measurements. Akciger Arsivi. 2005; 6: 63-68.

Fayez Kheir, MD, MSCR

Assistant Professor of Medicine
Section of Pulmonary, Critical Care and Environmental Medicine
Tulane University
New Orleans, LA, USA

BiographyResearch InterestScientific ActivitiesPublications

Dr. Kheir received his medical degree from University of Balamand, Lebanon. He completed his fellowship training at Tulane in Pulmonary and Critical Care Medicine in 2013, subsequently joining the Tulane faculty as an Assistant Professor of Clinical Medicine. Recently,he completed Masters of Science in Clinical Research. Dr. Kheir is board certified in Internal Medicine, Pulmonary Disease, and Critical Care Medicine. He is a member of the American College of Chest Physicians and the American Thoracic Society.His clinical and research interests are thoracic and critical care ultrasound use, medical education andpleural diseases.

His research interests include Lung ultrasound, Lung cancer, Endobronchial ultrasound, Respiratory Tract Infection, Pleural diseases.

COMMITTEES

• Tulane University Health Sciences Center
• (2013-Present) Fellowship Clinical Competence Committee


MEDICAL LICENSURE AND CERTIFICATION

• Licensed Louisiana MD.203862, Illinois 036124252 (inactive)
• Certified Specialty Internal Medicine (2010), Pulmonary (2012), Critical Care (2013)
• ECFMG certified (2007)
• Stanford Faculty Development Program for Clinical Teaching certified (2014)


MEMBERSHIPS

• American College of Chest Physicians
• American Thoracic Society


PRINCIPAL INVESTIGATOR

• A Phase 2 Randomized, Double-Blind Placebo-Controlled Trial of MHAA4549A in Combination with Oseltamivir versus Oseltamivir for Treatment of Severe Influenza A Infection
• DNA Repository Sub-study in Association with MHAA4549A Study
• International Multi center Prevalence Study on Sepsis (IMPRESS)
• Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure (LUNG SAFE)


INVITED PRESENTATIONS

• January 2011 Annual Tri-State Case Conference, New Orleans, LA A 32- Year-old Man with Recurrent Kidney Stones and an Abnormal Chest Radiograph
• March 2013 Work In Progress Research Conference, Tulane University Health Center Impact of a 24 hour Post-Intensive Care Unit Transition-of-Care Model on Patient Outcomes
• April 2013 Grand Round at Pulmonary, Critical Care and Environmental Medicine, Tulane University Health Center Portopulmonary Hypertension
• July 2013 Work In Progress Research Conference, Lung Transplant Meeting, Ochsner Clinic Outcomes of Predicted Total Lung Capacity in Bilateral Lung Transplantation
• February 2014 Department of Internal Medicine, Tulane University Health Center. The Evaluation of Pleural Effusion
• May 2014 Tulane University School of Medicine Teaching Scholars Education Day Using Simulation-Based Training to Incorporate Lung Ultrasound into Physical Examination

ORIGINAL RESEARCH

1. Mohd H, Kheir F, Lan K, et al. The Incidence and Predictors of Vancomycin Associated Nephrotoxicity. South Med J. 2014; 107(6): 383-388. doi: 10.14423/01.SMJ.0000450716.84291.59
2. Kheir F, Alokla K, Myers L, Palomino J. Endobronchial Ultrasound Transbronchial Needle Aspiration of Mediastinal and Hilar Lymphadenopathy Learning Curve. Am J Ther.
3. Kheir F, Myers L, Desai N, Simeone F. The Effect of Flow Trigger on Rapid Shallow Breathing Index (RSBI) Measured through the Ventilator. J Intensive Care Med. 2013.
4. Copur A, Fulambarker F, Molnar J, et al. Role of Anemia in Home Oxygen Therapy in Chronic Obstructive Pulmonary Disease (COPD) Patients. Am J Ther. 2013.
5. Kheir F, Palomino J. Endobronchial Ultrasound Transbronchial Needle Aspiration in Mediastinal and Hilar Lympadenopathies. South Med J. 2012; 105(12): 645-649. doi: 10.1097/SMJ.0b013e3182749150
6. Fulambarker A, Farooki B, Kheir F, Copur AS, Srinivasan L, Schultz S. Effect of Yoga in Chronic Obstructive Pulmonary Disease. Am J Ther. 2012; 19(2): 96-100. doi: 10.1097/MJT.0b013e3181f2ab86
7. Alhosaini MN, Latta S, Riaz K, et al. Contrast-induced nephropathy: current practices among cardiologists. Ren Fail. 2010; 32(8): 928-934. doi: 10.3109/0886022X.2010.502280


Review Articles

1. Omballi M, Kheir F. Treatment of Recurrent Non Malignant Pleural Effusions. Austin J Pulm Respir Med. 2014; 1(4): 3.
2. Kheir F, Eissa K, Palomino J. Screening for Lung Cancer. J Cancer Biol Res. 2014; 2(1): 10-23.
3. Kheir F, Haddad R. Anemia in the elderly. Dis Mon. 2010; 56(8): 456-467.
4. Jallad B, Hamdi T, Latta S, Alhosaini MN, Kheir F, Iroegbu N. Tumor lysis syndrome in small cell lung cancer: a case report and review of the literature. Onkologie. 2011; 34(3): 129-131.
5. Hamdi T, Latta S, Jallad B, Kheir F, Alhosaini MN, Patel A. Cisplatin-induced renal salt wasting syndrome. South Med J. 2010; 103(8): 79-39. doi: 10.1097/SMJ.0b013e3181e63682


Clinical Cases

1. Kheir F, Daroca P, Lasky J. Phenytoininduced vasculitis: a case report. Am J Ther. 2013.
2. Alraiyes A, Alokla K ,Kheir F, Palomino J. Endobronchial Ultrasound In A Patient With Right Aortic Arch . Ochsner J. 2014; 14(2): 279-281.
3. Eisa N, Mohd H, Alraiyes A, Shaheen K, Kheir F. Spontaneous Epidural Air Entrapment. Ochsner J. 2014; 14(2): 24-03.
4. Kheir F, Alraiyes AH, Salerno D, Alraies MC. Lung Air Fluid Level in a Smoker. Cleve Clin J Med. 2013; 80(8): 50-01. doi: 10.3949/ccjm.80a.12107
5. Eisa N, Mehta A, Shaheen K, Raheem SA, Kheir F. A Skin Nodule in a 66-year old man as Sign of an Ominous Prognosis. J La State Med Soc. 2013; 165(3): 14-21.
6. Alraiyes AH, Kheir F, Hirsh S, Salerno D, Green LB, Daroca P. A 40-Year Old Woman with Multiple Lung Nodules. Chest. 2013; 143(6): 182-69. doi: 10.1378/chest.12-1795
7. Kheir F, Simeone F, Johnston D, Shackelford R, Lasky J. A 32-year old Man with Recurrent Kidney Stones and An Abnormal Chest Radiograph. Chest. 2011; 140(6): 1654-1658. doi: 10.1378/chest.10-3268
8. Kheir F, Hamdi T, Khayr W, Latta S. Am J. Non resolving Pneumonia. Ther.2011; 18(5): e17-79.
9. Latta S, Myint Z, Jallad B, et al. Primary central nervous system Tcell lymphoma in aids patients: case report and literature review. Curr Oncol. 2010; 17(5): 6-36.


Editorials/ Rapid Communication

1. Assasa O, Omballi M, Kheir F. Should Endobronchial Ultrasound be Performed in All Patients with Suspected Sarcoidosis? Int J Respir Pulm Med. 2014; 1: 00-1e.
2. Assasa O, Kheir F. Nutrition in Critically Ill Patients. Austin Crit Care J. 2014; 1(1): 2.
3. Kheir F, Salerno DA. Brain Natriuretic Peptide Measurement in COPD Patients with Cardiovascular Disease. Chest. 2013; 144(3): 10-81.

Vivek Gupta, PhD

Assistant Professor
Biopharmaceutical Sciences
School of Pharmacy
Keck Graduate Institute (KGI)
535 Watson Dr., Claremont
CA 91711, USA

BiographyResearch InterestScientific ActivitiesPublications

Dr. Gupta is an Assistant Professor of Biopharmaceutical Sciences at School of Pharmacy, Keck Graduate Institute in California. Dr. Gupta received a B.S. in pharmaceutical sciences from JamiaHamdard (University) in New Delhi, India; and a PhD in Pharmaceutical Sciences from School of Pharmacy, Texas Tech University Health Sciences Center, USA. He completed his postdoctoral training at University of California Santa Barbara (UCSB). Dept. of Chemical Engineering.

His current research is focused at developing therapeutic regimens for various respiratory and cardiopulmonary diseases including Pulmonary Arterial Hypertension (PAH), and idiopathic pulmonary fibrosis (IPF). He is seeking new novel small molecules for treating PAH and IPF; and is also looking into developing targeted drug delivery systems for localizing therapies into pulmonary vascular endothelium.

INVITED TALKS

• Inhalable PGE1 Formulations for Treatment of Pulmonary Arterial Hypertension (PAH), Sanford Burnham Institute for Medical Research, May 2011


AWARDS AND RECOGNITIONS

• 2013 Excellence in Mentoring Award, Center for Science and Engineering Partnerships, CNSI, University of California Santa Barbara (UCSB) for mentorship of undergraduate students (June 2013)
• 2012 Otis Williams Postdoctoral Fellowship in Bioengineering, sponsored by Santa Barbara Foundation through College of Letters and Science, UCSB. Annual Award: $70,424
• 2011 Outstanding Graduate Student Award, Graduate School of Biomedical Sciences Convocation, Texas Tech University Health Sciences Center, Lubbock, TX
• Travel Award-AAPS Executive Council, 2010 FIP PSWC/AAPS Annual Meeting and Exposition, New Orleans, LA.
• 2nd Prize-Graduate Students Poster Competition 2009 organized by Texas Tech-AAPS Student Chapter at AAPS Annual Meeting, Los Angeles, CA.
• 2009 GSAA Student of the Year Graduate Students Association at Amarillo (GSAA) at SOP, TTUHSC
• GSAA Travel Scholarship 2008, 2009, 2010

PEER REVIEWED ARTICLES AND BOOK CHAPTERS

1. Chen M, Zekrewsky M, Gupta V, Anselmo AC, Muraski JA, Mitragotri S. Topical Delivery of sirna into Skin using SPACE-peptide Carriers. Journal of Controlled Release. 2014; 179: 33-41. doi: 10.1016/j.jconrel.2014.01.006
2. Anselmo AC, Gupta V, Zern B, Pan D, Muzykantov V, Mitragotri S. Delivering Nanoparticles to Lungs While Avoiding Liver and Spleen through Adsorption on Red Blood Cells. ACS Nano. 2013; 7(12): 11129-11137. doi: 10.1021/nn404853z
3. Chen M, Gupta V, Anselmo AC, Muraski JA, Mitragotri S. Topical Delivery of Hyaluronic Acid into Skin using SPACE-peptide Carriers. Journal of Controlled Release. 2013; 173: 67-74. doi: 10.1016/j.jconrel.2013.10.007
4. Gupta V, Hwang BH, Lee J, Anselmo AC, Doshi N, Mitragotri S. Mucoadhesive Intestinal Devices for Oral Delivery of Salmon Calcitonin. Journal of Controlled Release. 2013; 172(3): 753-762. doi: 10.1016/j.jconrel.2013.09.004
5. Nahar K, Gupta N, Gauvin R, et al. In Vitro, In Vivo and Ex Vivo Models for Studying Particle Deposition and Drug Absorption of Inhaled Pharmaceuticals. European Journal of Pharmaceutical Sciences. 2013; 49(5): 805-818. doi: 10.1016/j.ejps.2013.06.004
6. Gupta V, Hwang BH, Doshi N, Mitragotri S. A Permeation Enhancer for Increasing Transport of Therapeutic Macromolecules across the Intestine. Journal of Controlled Release. 2013; 172(2): 541-549. doi:
7. Gupta V, Gupta N, Shaik IH, et al. Inhaled PLGA Particles of Prostaglandin E1 Ameliorate Symptoms and Progression of Pulmonary Hypertension at a Reduced Dosing Frequency. Molecular Pharmaceutics. 2013; 10(5): 1655-1667. doi: 10.1021/mp300426u
8. Gupta V, Gupta N, Shaik IH, et al. Liposomal Fasudil, a Rho-Kinase Inhibitor, for Prolonged Pulmonary Preferential Vasodilation in Pulmonary Arterial Hypertension. Journal of Controlled Release. 2013; 167(2): 189-199. doi: 10.1016/j.jconrel.2013.01.011
9. Gupta V, Doshi N, Mitragotri S. Permeation of Insulin, Calcitonin and Exenatide across Caco-2 Monolayers: Measurement using a Rapid, 3-Day System. PLOS One. 2013; 8(2): e57136. doi: 10.1371/journal.pone.0057136
10. Patel BI, Gauvin R, Absar S, et al. Computational and Bio-engineered Lungs as Alternatives to Whole Animal, Isolated Organ and Cell-Based Lung Models. American Journal of Physiology – Lung Cellular and Molecular Physiology. 2012; 303(9): L733-L747. doi: 10.1152/ajplung.00076.2012
11. Patel B, Gupta V, Ahsan F. PEG-PLGA Based Large Porous Particles for Pulmonary Delivery of a Highly Soluble Drug, Low Molecular Weight Heparin. Journal of Controlled Release. 2012; 162(2): 310-320. doi: 10.1016/j.jconrel.2012.07.003
12. Gupta V, Ahsan F. Influence of PEI as a Core Modifying Agent on PLGA Microspheres of PGE, A Pulmonary Selective Vasodilator. International Journal of Pharmaceutics. 2011; 413(1-2): 51-62. doi: 10.1016/j.ijpharm.2011.04.017
13. Gupta V, Davis M, Hope-Weeks LJ, Ahsan F. PLGA Microparticles Encapsulating Prostaglandin E1-Hydroxypropyl-β-cyclodextrin (PGE1-HPβCD) Complex for the Treatment of Pulmonary Arterial Hypertension (PAH). Pharmaceutical Research. 2011; 28(7): 1733-1749. doi: 10.1007/s11095-011-0409-6
14. Gupta V, Ahsan F. Inhalational Therapy for Pulmonary Arterial Hypertension: Current Status and Future Prospects. Critical Reviews TM in Therapeutic Drug Carrier Systems. 2010; 27(4): 313-370.
15. Gupta V, Rawat A, Ahsan F. Feasibility Study of Aerosolized Prostaglandin E1Microspheres as a Non-Invasive Therapy for Pulmonary Arterial Hypertension. Journal of Pharmaceutical Sciences. 2010; 99(4): 1774-1789. doi: 10.1002/jps.21946
16. Thomas C, Gupta V, Ahsan F. Particle Size Influences the Immune Response Produced by Hepatitis B Vaccine Formulated in Inhalable Particles. Pharmaceutical Research. 2010; 27(5): 905-919. doi: 10.1007/s11095-010-0094-x
17. Bai S, Gupta V, Ahsan F. Inhalable Lactose-based Dry Powder Formulations of Low Molecular Weight Heparin. Journal of Aerosol Medicine and Pulmonary Drug Delivery. 2010; 23(2): 97-104. doi: 10.1089/jamp.2009.0745
18. Bai S, Gupta V, Ahsan F. Cationic Liposomes as Carriers for Aerosolized Formulations of an Anionic Drug: Safety and Efficacy Study. European Journal of Pharmaceutical Sciences. 2009; 38(2): 165-173. doi: 10.1016/j.ejps.2009.07.002
19. Thomas C, Gupta V, Ahsan F. Influence of Surface Charge of PLGA Particles of Recombinant Hepatitis B Surface Antigen in Enhancing Systemic and Mucosal Immune Responses. International Journal of Pharmaceutics. 2009; 379(1): 41-50. doi: 10.1016/j.ijpharm.2009.06.006

Ling Chen, BM, MMed, MD

Assistant Professor
Departments of Physiology and Medicine
Director, Physiological Genotyping Core
University of Maryland School of Medicine
685 West Baltimore St, MSTF 816
Baltimore, MD 21201, USA

BiographyResearch InterestScientific ActivitiesPublications

Dr. Ling Chen is Assistant Professor of Physiology and Medicine at the University of Maryland School of Medicine. His research is focused on integrative and molecular mechanisms of cardiovascular injury following to intermittent hypoxia, post-infarct remodeling, and salt-sensitive hypertension. He is directing the Physiological Genotyping Core for the School, which provides cutting-edge services focusing on cardiorespiratory models and in vivo measurements.

His research is focused on integrative and molecular mechanisms of cardiovascular injury following to intermittent hypoxia, post-infarct remodeling, and salt-sensitive hypertension; Cardio-respiratory models and in vivo measurements.

INSTITUTIONAL SERVICE

Since 2003, he had provided consultations to UMB investigators on development and preparation of Institutional Animal Care and Use protocols in the area of in vivo cardio respiratory models and measurements. Currently, He is named as a co-investigator in 10 active UMB protocols.


INVITED SPEECHES

1. American Thoracic Society 1997 International Conference. Title: “Role of sympathoadrenal activation in acute hemodynamic response to simulated central apnea in sedated pigs”. 1997, San Francisco, CA
2. Physiology Seminar, Department of Physiology, University of Maryland, Baltimore. April 27, 2006. Title: “Sodium Hydrogen Exchanger-1 and Left Ventricular Function in Chronic Intermittent Hypoxia"
3. New Horizons in Sleep II, University of Maryland School of Medicine. Title: “Cardiac hypertrophy in animal model of sleep apnea”. June 9, 2006
4. Telemetry Educational Symposium, Data Sciences International, Inc and the University of Maryland School of Medicine. Title: “Cardiovascular response to chronic intermittent hypoxia in mice”. May 24, 2006
5. Seminar Series, the Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine. Title: “Na/H exchanger-1 and cardiac function in chronic intermittent hypoxia”. October 18, 2006
6. American Thoracic Society 2006 International Conference. Title: “Chronic intermittent hypoxia upregulates myocardial expression of sodium hydrogen exchanger-1 in rats”. San Diego, CA. May 19-24, 2006
7. Seminar at the Cardiovascular Laboratories, Renmin Hospital, Wuan University School of Medicine, Wuhan, China. Oct 28, 2008. Title: “Cardiac injury of chronic intermittent hypoxia”.
8. Mini-symposium, Changzheng Hospital, Second Military Medical University, Shanghai, China. “Cardiovascular consequence of obstructive sleep apnea”. November 3, 2008
9. Frontier in Heart Research, Second Military Medical University, Shanghai, China. Title: “Na+/H+ exchanger-1 pathway and cardiac injury in chronic intermittent hypoxia”. Aug 3, 2009
10. Physiology Seminar. Department of Physiology, University of Maryland School of Medicine. Title: “Cardiac injury in chronic intermittent hypoxia”, June 10, 2010.
11. Pulmonary Seminar. Division of Pulmonary and Critical Care Medicine, University of Maryland School of Medicine. Title: “Na+/Ca2+ exchanger-1 and cardiac injury in chronic intermittent hypoxia”. Oct 22, 2010
The High Blood Pressure Research 2013 Scientific Sessions, American Heart Association. Title: “Blood pressure correlates directly with the expression level of high ouabain affinity α2 Na+ pumps in arterial smooth muscle”, Sept 11-14, 2013, New Orleans.
12. The council meeting of University of Maryland School of Medicine. Title: “Cardiovascular effects of chronic intermittent hypoxia”. March 26, 2014


1. Chen L, Deng K, Ye Y, Luo W, Zhao J, Sheng M. Effects of ipratropium bromide and its combination with salbutamol sulphate on acute asthmatics. Chin J Intern Med. 1989; 28: 657-666.
2. Chen L, Lin B. Neuropeptides in the respiratory system. Trends Nat Foreign Med Sci. 1992; 7: 131-138. doi: 10.1164/ajrccm/144.5.1187
3. Chen L, Luo W. Plasma endothelin-1 and pulmonary hemodynamic at pre- and post-exercise in chronic obstructive pulmonary disease. Chin J Tubercul Respir Dis. 1996; 19: 212-215.
4. Sun R, Luo W, Chen L. Plasma endothelin-1 and its clinical evaluation in asthma. Chin J Tubercul Respir Dis. 1995; 18: 193-195.
5. Scharf SM, Chen L, Slamowitz D, Rao PS. Effects of continuous positive airway pressure on cardiac output and plasma norepinephrine in sedated pigs. J Crit Care. 1996; 11(2): 57-64. doi: http://dx.doi.org/10.1016/S0883-9441(96)90021-0
6. Cohen RI, Chen L, Scharf SM. The effects of high dose NG-nitro-L-arginine-methyl ester on myocardial blood flow and left ventricular function in dogs. J Crit Care. 1996; 11(4): 206-213.
7. Chen L, Scharf SM. Comparative hemodynamic effects of periodic obstructive and simulated central apneas in sedated pigs. J Appl Physiol. 1997; 83(2): 485-494.
8. Tarasiuk A, Chen L, Scharf SM. Effects of periodic obstructive apnoeas on superior and inferior venous return in dogs. Acta Physiol Scand. 1997; 161(2): 187-194. doi: 10.1046/j.1365-201X.1997.00208.x
9. Sofer S, Cohen R, Shapir Y, Chen L, Colon A, Scharf SM. Scorpion venom leads to gastrointestinal ischemia despite increased oxygen delivery in pigs. Crit Care Med. 1997; 25(5): 834-840.
10. Chen L, Sica AL, Greenberg H, Scharf SM. Role of hypoxemia and hypercapnia in acute cardiovascular response to periodic apneas in sedated pigs. Respir Physiol. 1998; 111(3): 257-269. doi: 10.1016/S0034-5687(98)00007-3
11. Chen L, Scharf SM. Systemic and myocardial hemodynamics during periodic obstructive apneas in sedated pigs. J Appl Physiol. 1998; 84(4): 1289-1298.
12. Cohen RI, Shapir Y, Chen L, Scharf SM. Right ventricular overload causes the decrease in cardiac output after nitric oxide synthesis inhibition in endotoxemia. Crit Care Med. 1998; 26(4): 738-747. doi: 10.1097/00003246-199804000-00026
13. Slamowitz D, Chen L, Scharf SM. Effects of vagotomy on cardiovascular response to periodic apneas in sedated pigs. J Appl Physiol. 1999; 86(6): 1890-1896.
14. Chen L, Sica AL, Scharf SM. Mechanisms of acute cardiovascular response to periodic apneas in sedated pigs. J Appl Physiol. 1999; 86(4): 1236-1246.
15. Chen L, Shi Q, Scharf SM. Hemodynamic effects of periodic obstructive apneas in sedated pigs with congestive heart failure. J Appl Physiol. 2000; 88(3): 1051-1060.
16. Chen L, Scharf SM. Effects of aortic nerve on hemodynamic response to obstructive apnea in sedated pigs. J Appl Physiol. 2000; 89(4): 1455-1461.
17. Chen L, Gan XT, Haist JV, et al. Attenuation of compensatory right ventricular hypertrophy and heart failure following monocrotaline-induced pulmonary vascular injury by the Na+-H+ exchange inhibitor cariporide. J Pharmacol Exp Ther. 2001; 298(2): 469-476.
18. Rojas A, Chen L, Bartlett RH, Arenas JD. Assessment of liver function during extracorporeal membrane oxygenation in the non-heart beating donor swine. Transplant Proc. 2004; 36(5): 1268-1270.doi: http://dx.doi.org/10.1016/j.transproceed.2004.05.011
19. Chen L, Chen CX, Gan XT, Beier N, Scholz W, Karmazyn M. Inhibition and reversal of myocardial infarction-induced hypertrophy and heart failure by NHE-1 inhibition. Am J Physiol Heart Circ Physiol. 2004; 286(1): H381-H387. doi: 10.1152/ajpheart.00602.2003
20. Chen L, Einbinder E, Zhang Q, Balke CW, Hasday J, Scharf SM. Oxidative Stress and Left Ventricular Function with Chronic Intermittent Hypoxia in Rats. Am J Respir Crit Care Med. 2005; 172(7): 915-920. doi: 10.1164/rccm.200504-560OC
21. Zhang J, Lee MY, Cavalli M, et al. Sodium pump alpha-2 subunits, arterial myogenic tone and pathogenesis of hypertension. J Physiol. 2005; 569(1): 243-256. doi:
22. Blaustein MP, Zhang J, Chen L, Hamilton BP. How does salt retention raise blood pressure? Am J Physio. Reg Int Comp Physiol. 2006; 290(3): R514-R523. doi: 10.1152/ajpregu.00819.2005
23. Chen-Izu Y, Chen L, Banyasz T, et al. Hypertension-induced remodeling of cardiac excitation-contraction coupling in ventricular myocytes occurs prior to hypertrophy development. Am J Physiol Heart Circ Physiol. 2007; 293: H3301-H3310. doi: 10.1152/ajpheart.00259.2007
24. Chen L, Zhang J, Gan T, et al. Left ventricular dysfunction and associated cellular injury in rats exposed to chronic intermittent hypoxia. J Appl Physiol. 2008; 104: 218-223. doi: 10.1152/japplphysiol.00301.2007
25. Blaustein MP, Zhang J, Chen L, et al. CHBPR: Novartis award for hypertension research - the pump, the exchanger and endogenous ouabain: signaling mechanisms that link salt retention to hypertension. Hypertension. 2009; 53(2): 291-298. doi:
26. Williams AL, Chen L, Scharf SM. Effects of allopurinol on cardiac function and oxidant stress in chronic intermittent hypoxia. Sleep Breath. 2009; 14(1): 51-57. doi: 10.1007/s11325-009-0279-x
27. Zhang J, CY Ren, Chen L, et al. Knockout of Na+/Ca2+ exchanger in smooth muscle attenuates vasoconstriction and L-type Ca2+ channel current, and lowers blood pressure. Am J Physiol Heart Circ Physiol. 2010; 298(5): H1472-H1483. doi: 10.1152/ajpheart.00964.2009
28. Zhang J, Chen L, Raina H, Blaustein MP, Wier WG. In vivo measurement of arterial pressure, [Ca2+] and MLCK activation in FRET-based biosensor mice. Am J Physiol Heart Circ Physiol. 2010; 299(3): H946-H956.
29. Chen L, J Zhang, Philipson KD, Scharf SM. Cardiac specific Na/Ca exchanger-1 knockout attenuates cardiac injury in chronic intermittent hypoxia. J Appl Physiol. 2010; 109: 1675-1685.
30. Xu KY, Zhu W, Chen L, et al. Mechanistic distinction between activation and inhibition of Na+-K+-ATPase-mediated Ca2+ influx in cardiomyocyte. Biochem Biophys Res Com. 2011; 406(2): 200-203.
31. Yakovlev S, Gao Y, Cao C, et al. Interaction of fibrin with VE-cadherin and anti-inflammatory effect of fibrin-derived fragments. J Thromb Haemost. 2011; 9(9): 1847-1855. doi: 10.1111/j.1538-7836.2011.04438.x
32. Sakoda Y, Anand S, Zhao Y, et al. Herpesvirus entry mediator regulates hypoxia-inducible factor-1α and erythropoiesis in mice. J Clin Invest. 2011; 121(12): 4810-4819. doi: 10.1172/JCI57332
33. Blaustein MP, Leenen FH, Chen L, et al. How NaCl raises blood pressure: a new paradigm for the pathogenesis of salt-dependent hypertension. Am J Physiol Heart Circ Physiol. 2012; 302(5): H1031-H1049. doi: 10.1152/ajpheart.00899.2011
34. Muratoglu SC, Belgrave S, Hampton B, et al. LRP1 protects the vasculature by regulating levels of Connective Tissue Growth Factor and HtrA1. Arterioscl Thromb Vasc Biol. 2013; 33(9): 2137-2146. doi: 10.1161/ATVBAHA.113.301893
35. Wang Y, Chen L, Wier WG, Zhang J. Intravital FRET imaging reveals elevated [Ca2+]i and enhanced sympathetic tone in femoral arteries of angiotensin II-infused hypertensive biosensor mice. J Physiol. 2013; 591(21): 5321-5336. doi: 10.1113/jphysiol.2013.257808

Kamal A Mohammed, PhD

Associate Professor
Division of Pulmonary Critical Care and Sleep Medicine
Department of Medicine
University of Florida and Chair, Subcommittee for Research Safety
North Florida/South Georgia Veterans Health System
Malcom Randall VA Medical Center
Gainesville, FL-32608, USA

BiographyResearch InterestScientific ActivitiesPublications
Education:

• (1993): PhD in Immunology from Osmania University, INDIA. PhD. Thesis title: Immunomodulatory effects of Plumbagin (5-Hydroxy- 2- Methyl-1, 4- naphthoquinone) in BALB/c mice
• (1986): MS (Zoology), First Division with top 3% at Osmania University, INDIA
• (1984): BS (Biology, Applied Nutrition & Public Health), First Division with distinction, Osmania University, INDIA


Research & Development-Subcommittees


• (2004-Present): Chair, Subcommittee for Research Safety, North Florida/South Georgia Veterans Health Care System, Malcom Randall VAMC, Gainesville, FL
• (2005-Present): Research and Development Committee, North Florida/South Georgia Veterans Health Care System, Malcom Randall VAMC, Gainesville, FL
• (2004-Present): Institutional Animal Care and Use Committee (IACUC) North Florida/South Georgia Veterans Health Care System, Malcom Randall VAMC, Gainesville, FL
• (2008-Present): Scientific grants review (Reorganization) committee, North Florida/South Georgia Veterans Health Care System, Malcom Randall VA Medical Center, Gainesville, FL
• 2008-Present): Research Space Utilization Committee, North Florida/South Georgia Veterans Health Care System, Malcom Randall VA Medical Center, Gainesville, FL
• (2006-Present): Research Task Force Division of Pulmonary Critical Care and Sleep Medicine, University of Florida, Gainesville, FL
• (2006-Present): Research Advisory Committee MD-PEDS-Critical Care Division, University of Florida, Gainesville, FL
• (2003-2004): Subcommittee for Research Safety, North Florida/South Georgia Veterans Health Care System, Malcom Randall VA Medical Center, Gainesville, FL
• (2002-2003): Subcommittee for Radiation Safety, Veterans Administration Medical center, Indianapolis, IN
• (2001-2003): Subcommittee for Research Bio-safety, Veterans Administration Medical center, Indianapolis, IN


Teaching Experience:


• (2013-Present): Mechanisms of Innate Immune Defenses in MRSA induced Pleural Empyema. Satindra Gehlot, PhD, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Florida, Gainesville, FL
• (2009-Present): Receptor Tyrosine Kinase Signaling in Thoracic Malignancies. Hun-Yen Lee, PhD, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Florida, Gainesville, FL
• (2010-2013): Significance of MicroRNA signaling in Pleural Mesothelial Cell Epithelial Mesenchymal Transition. Bhagayalaxmi Sukka-Ganesh, PhD, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Florida, Gainesville, FL
• (2010-2012): Role of EphA2 signaling and MCL-1 in Malignant Pleural Mesothelioma. Nazli Khodayari, PhD, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Florida, Gainesville, FL
• (2009-2010): Significance of SOCS3 signaling in Airway Inflammation. Lixandra Gonzalez, BS, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Florida, Gainesville, FL
• (2006-2008): TLR-2 signaling in pleural mesothelial innate immune defenses in Staphylococcal infection. Tajamul Hussain, PhD, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Florida, Gainesville, FL
• (2006-2008): Veterinary Immunology course (VEM5110B). College of Veterinary Medicine, University of Florida, Gainesville, FL
• (2006-2007): Role of Cylcin D1 in Cyclical Stretch Induced Bronchial Smooth Muscle Cell Proliferation. (PhD), Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Florida, Gainesville, FL
• (2003-2006): Significance of Hemoxygenase-1 signaling in Mycobacterium avium infection. Yimu Lai, PhD, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Florida, Gainesville, FL
• (2002): Role of the focal adhesion protein Paxillin in pleural permeability. Research project: Carlos Ramirez-Icaza, M.D. Fellow in Pulmonary and Critical Care Medicine, VA Medical Center, Indiana University
• (2002): Mechanisms of RSV mediated permeability changes in bronchial airway epithelial cells. Research project: Muna Kilani, MD. Fellow in Pediatric Pulmonary and Critical Care Medicine, VA Medical Center, Indiana University
• (2002): Defensive role of pleural mesothelial cell sialomucin in pleural metastasis. Research project. Ramit K. Sharma, MD. Fellow in Pulmonary and Critical Care Medicine, VA Medical Center, Indiana University
• (2001): Repair Mechanisms In Bronchial Epithelial Monolayer: Role Of CCR2 Receptor. Research project: Matthew Lundien, M.D. Fellow in Pulmonary and Critical Care Medicine, VA Medical Center, Indiana University
• (2001): Metastatic Ovarian Cancer Increases Pleural Permeability. Research project : Shriram P.S., M.D. Fellow in Pulmonary Critical Care Medicine, VA Medical Center, Indiana University
• (2000): Human Pleural Fibroblast Expression of C-C (Monocyte Chemotactic Peptide) and C-X-C (Interleukin 8) Chemokines. Research project : Farzad Loghmani, M.D. Fellow in pulmonary Critical Care Medicine, VA Medical Center, Indiana University
• (1999): Low but not high molecular weight hyaluronan induces chemotactic response in human malignant mesothelioma. Research project: Hasmeena Kathuria, M.D., Fellow in Pulmonary and Critical Care Medicine, VA Medical Center, Indiana University
• (1998): Staphylococcus aureus mediates Murine KC and MIP-2 expression in Pleural Mesothelial cells. Research Project: Nikia S Brown, B.S. Graduate summer trainee, VA Medical Center, Indiana University
• (1996): Effect of Mesothelial cells on Neutrophil Apoptosis in Pleural Space. Research Project: John B. Harness, B.S. Graduate summer trainee, VA Medical Center, Indiana University
• (1996): Regulation of MIP-1 Expression in Mesothelial cells. Research Project : Kelli E. Daniels, B.S. Graduate summer trainee, VA Medical Center, Indiana University
• (1993-1994): Teaching Immunology and Biochemistry to masters graduate students at Osmania University - Nizam’s College, INDIA


Research Experience:


• (2003-Present): Research Health Scientist, (a 5/8 appointment) North Florida/South Georgia Veterans Health Care System, Malcom Randall VAMC, University of Florida, Gainesville, FL
• (Jan 2010-Present). Research Associate Professor, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Florida, Gainesville, FL
• (Nov 2003-Dec 2009). Assistant Professor, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Florida, Gainesville, FL
• (2000-2003): Research Health Scientist, (a 5/8 appointment) Roudebush VAMC, Indianapolis, Indiana University Medical Center, Indianapolis, IN
• (1999-2003): Assistant Scientist, Division of Pulmonary, Critical Care & Occupational Medicine, Indiana University School of Medicine, VA Medical Center, IUPUI, Indianapolis, IN, USA
• (1997-1999): Research Associate (WOC appointment at VA Medical Center), Division of Pulmonary, Critical Care & Occupational Medicine, Indiana University School of Medicine, VA Medical Center, IUPUI, Indianapolis, IN, USA
• (1995-1997): Post Doctoral Fellow (WOC appointment at VA Medical Center), Division of Pulmonary, Critical Care & Occupational Medicine, Indiana University School of Medicine, VA Medical Center, IUPUI, Indianapolis, IN, USA
• (1994-1995): Post Doctoral Fellow, Center for Cellular & Molecular Biology, Hyderabad, INDIA
• 1994-1994): Research Associate, Institute of Microbial Technology, Chandigarh, INDIA
• (1990-1993): Senior Research Fellow, (NET) Osmania University, Hyderabad, INDIA
• (1987-1990): Junior Research Fellow, (NET) Osmania University, Hyderabad, INDIA

His research interests include: Mechanisms of lung injury in Chronic Obstructive Pulmonary Disease, Pneumonia, and pleural fibrosis. Mechanisms of Toll-like receptor signaling in lung infections and micro-RNA signaling in lung inflammation/injury. Mechanisms of epithelial barrier functions, and cellular traffic in lung infection/injury.

Workshops & Courses:


1. IUIS - WHO Advanced Course on Basic Immunology organized by the International Union of Immunology and All India Institute of Medical Sciences (AIIMS), New Delhi, INDIA. November 1993.
2. Training in Interferon Bio-Assays at National Institute of Virology (A WHO Collaborating Center for Arbovirus Reference and Research), Pune, INDIA. February 1991.
3. IUIS - WHO Advanced Immunology Course (Focus on the immunology of infectious diseases) organized by the International Union of Immunology Society, World Health Organization, and All India Institute of Medical Sciences (AIIMS), New Delhi, INDIA. November 1989.
4. Molecular Biology course Indiana University School of Medicine. IUPUI, Indianapolis, IN. June 8-25, 1998.
5. Radiation-Safety course Indiana University School of Medicine. IUPUI, Indianapolis, IN. June 8-25, 1997.


Membership in Scientific Societies:


1. Member of American Federation for Medical Research.
2. Member of American Thoracic Society.
3. Member of American Society for Pharmacology and Experimental Therapeutics.
4. Member of Indiana Thoracic Society, The Medical Section of the American Lung Association of Indiana.


Invited Seminars

1. Mohammed, KA. “Significance of miR-26 in Pleural Empyema” presented at the Division of Pulmonary, Critical Care & Sleep Medicine, University of Florida, (2012).
2. Mohammed, KA. “Experimental Models in Lung Diseases” presented at the Work Shop on Research and Development, Kakatiya University, India; (July 2011).
3. Mohammed, KA. “Tuberculosis: Infection, Control and Prevention” presented at the Government Pingle PG College, Kakatiya University, India; (July 2011).
4. Mohammed, KA. “Significance of Hemeoxygenase-1in Pleural Fibrosis” presented at the Department of Medicine Retreat, University of Florida, (2011).
5. Mohammed, KA. “Role of Hemeoxygenase-1 in Pleural Mesothelial Cell Epithelial Mesenchymal Transition” presented at the Division of Pulmonary, Critical Care & Sleep Medicine, University of Florida, (2011).
6. Mohammed, KA. “Mechanisms of Pleural Fibrosis in Empyema” presented at the Division of Pulmonary, Critical Care & Sleep Medicine, University of Florida, (2010).
7. Mohammed, KA. “Beta-defensins in pleural infections” presented at the Division of Pulmonary, Critical Care & Sleep Medicine, University of Florida, (2009).
8. Mohammed, KA. “Heme Oxygenase-1 in TB Pleurisy” presented at the Division of Pulmonary, Critical Care & Sleep Medicine, University of Florida, (2008).
9. Mohammed, KA. “Innate Immunity: Significance in Pleural Infection” presented at the Division of Pulmonary, Critical Care & Sleep Medicine, University of Florida, (2007).
10. Mohammed, KA. “Inflamed Pleura: Innate Immune Responses of the Pleural Mesothelium” presented at the Division of Pulmonary, Critical Care & Sleep Medicine, University of Florida, (2007).
11. Mohammed, KA. Pleural Mesothelial Cells and Pleural Effusions” presented at the Veterinary College of Medicine, University of Florida, (2006).
12. Mohammed, KA. “Mechanical Forces in Lung Remodeling” presented at the Division of Pulmonary, Critical Care & Sleep Medicine, University of Florida, (2006).
13. Mohammed, KA. “Allergen Induced Asthma” presented at the Division of Pulmonary, Critical Care & Sleep Medicine, University of Florida, (2005).
14. Mohammed, KA. “Role Pleural Mesothelial Toll-like receptors in Empyema” presented at the Division of Pulmonary, Critical Care & Sleep Medicine, University of Florida, (2004).
15. Mohammed, KA. “Pleural Mesothelial Cells Bridging Innate and Adaptive Immune responses in Pleura” presented at the Division of Pulmonary, Critical Care & Occupational Medicine, Indiana University Medical Center, Indiana, (2003).
16. Mohammed, KA. “Pleural Infection and Mesothelial Barrier Dysfunction” presented at the Division of Pulmonary, Critical Care & Occupational Medicine, Indiana University Medical Center, Indiana, (2002).

1. Mohammed KA, Rao PR. Modulatory effect of Plumbagin (5- Hydroxy- 2- Methyl-1, 4-naphthoquinone) on Macrophage Functions in BALB/c mice I. I. Potentiation of Macrophage Bactericidal Activity. Immunopharmacology. 1995; 30(3): 231-236. doi: 10.1016/0162-3109(95)00027-Q
2. Ashok Khar KA, Usalya S, Mohammed KA. AK-5 tumor induced modulation of host immune function: Up-regulation of Th1 type Cytokine Response Mediates early Tumor Regression. Cytokines and Molecular Therapy. 1996; 2: 39-46.
3. Mohammed KA, Nasreen N, Ward MJ, Antony VB. Macrophage Inflammatory Protein-1a: A C-C Chemokine in Parapneumonic Pleural Effusions. J Lab Clin Med. 1998; 132(3): 202-209.
4. Mohammed KA, Nasreen N, Ward MJ, Panadero FR, Antony VB. Mycobacterium Mediated Chemokine Expression in Pleural Mesothelial Cells: Role of C-C Chemokines in Tuberculous Pleurisy. J Infec Dis. 1998; 178: 1450-1456. doi: 10.1086/314442
5. Nasreen N, Hartman DL, Mohammed KA, Antony VB. Talc Induces Pleural Mesothelial cell Expression of Proinflammatory Cytokines and Intercellular Adhesion Molecule-1 (ICAM-1). Am J Respir Crit Care Med. 1998; 158: 971-978.
6. Mohammed KA, Nasreen N, Ward MJ, Antony VB. Helper T-cell type 1 and 2 Cytokines Regulate C-C Chemokine Expression in Mesothelial Cells. Am J Respir Crit Care Med. 1999; 159: 1653-1659. doi: 10.1164/ajrccm.159.5.9810011
7. Nasreen N, Mohammed KA, Ward MJ, Antony VB. Mycobacterium-induced transmesothelial migration of monocytes into pleural space: role of intercellular adhesion molecule-1 in tuberculous pleurisy. J Infec Dis. 1999; 180(5): 1616-1623. doi: 10.1086/315057
8. Galffy G, Mohammed KA, Nasreen N, Ward MJ, Antony VB. Inhibition of interleukin-8 Reduces Malignant Pleural Mesothelioma Propagation in Nude Mouse Model. Interntl J Oncol Res. 1999; 11(4): 187-194.
9. Galffy G, Mohammed KA, Ward MJ, Dowling PA, Nasreen N, Antony VB. Interleukin-8, an Autocrine Growth Factor for Malignant Mesothelioma. Cancer Research. 1999; 59: 367-371.
10. Nasreen N, Mohammed KA, Dowling PA, Ward MJ, Antony VB. Talc Induces Apoptosis in Human Malignant Mesothelioma in vitro. Am J Respir Crit Care Med. 2000; 161(2(1)): 595-600. doi: 10.1164/ajrccm.161.2.9904123
11. Mohammed KA, Nasreen N, Ward MJ, Antony VB. Induction of Acute Pleural Inflammation by Staphylococcus aureus: I. CD4+ T cells Play a Critical Role in Experimental Empyema. J Infec Dis. 2000; 181(5): 1693-1699. doi: 10.1086/315422
12. Nasreen N, Mohammed KA, Ward MJ, Antony VB. MCP-1 in pleural injury: CCR2 mediates haptotaxis of pleural mesothelial cells. Am J Physiol - Lung Cellu Mol Physiol. 2000; 278(3): L591-L598.
13. Mohammed KA, Nasreen N, Hardwick J, et al. Antony. Bacterial Induction of Pleural Mesothelial Monolayer Barrier Dysfunction. Am J Physiol - Lung Cell Mol Physiol. 2001; 281: L119-L125.
14. Nasreen N, Mohammed KA, Hardwick J, et al. Polar Production of IL-8 By Mesothelial Cells Promotes The Transmesothelial Migration of Neutrophils: Role of ICAM-1. J Infec Dis. 2001; 183(11): 1638-1645. doi: 10.1086/320700
15. Loghmani F, Mohammed KA, Nasreen N, et al. Cytokines Mediate C-C (Monocyte Chemotactic Peptide) and C-X-C (Interleukin 8) Chemokine Expression in Human Pleural Fibroblasts. Inflammation. 2002; 26(2): 73-82.
16. Lundien MC, Mohammed KA, Nasreen N, et al. Induction of MCP-1 Expression in Airway Epithelial Cells : Role of CCR2 Receptor in Airway Epithelial Injury. J Clin Immunol. 2002; 22(3): 144-152.
17. Ajay B, Robert S, Mohammed KA. Cockroach Extract Allergen Induces Permeability Change in Human Bronchial Airway Epithelial Cells. J Allergy Clin Immunol. 2002; 110(4): 589-595.
18. Nasreen N, Mohammed KA, Sanders KL, et al. Staphylococcus aureus Stimulated Pleural Mesothelial Cells (PMC) Modulate Polymorphnuclear Leukocyte (PMN) Apoptosis. J Clin Immunol. 2003; 23(1): 1-10.
19. Nasreen N, Mohammed KA, Hardwick J, et al. Low molecular weight hyaluronan induces malignant mesothelioma cell (MMC) proliferation and haptotaxis: Role of CD44 receptor in MMC proliferation and haptotaxis. Oncology Research. 2002; 13(2): 71-78. doi: http://dx.doi.org/10.3727/096504002108748105
20. Shriram PS, Mohammed KA, Nasreen N, et al. Metastatic Ovarian Cancer Increases Pleural Permeability. Oncology Research. 2002; 13(2): 79-85.
21. Mohammed KA, Nasreen N, Hardwick J, et al. Mycobacteria Induces Pleural Mesothelial Permeability by down-regulating beta-catenin Expression. Lung. 2003; 181(2): 57-66. doi: 10.1007/s00408-003-1006-1
22. Sharma RK, Mohammed KA, Nasreen N, et al. Carlos Ramirez-Icaza, Antony VB. Defensive role of Pleural Mesothelial Cell (PMC) Sialomucins in Tumor Metastasis. Chest. 2003; 124(2): 682-687.
23. Icaza GR, Mohammed KA, Nasreen N, et al. Th2 Cytokines IL-4 and IL-13 Down Regulate Paxillin Expression in Bronchial Airway Epithelial Cells. J Clin Immunol. 2004; 24(4): 426-434.
24. Kilani MM, Mohammed KA, Nasreen N, Hardwick JA, Tepper RS, Antony VB. Respiratory Syncytial Virus Causes Increased Bronchial Epithelial Permeability. Chest.2004; 126(1): 186-191. doi: 10.1378/chest.126.1.186
25. Antony VB, Nasreen N, Mohammed KA, et al. Talc Pleurodesis: Pleural fluid bFGF mediates pleural fibrosis. Chest. 2004; 126(5): 1522-1528. doi: 10.1378/chest.126.5.1522
26. Kilani MM, Mohammed KA, Nasreen N, Tepper RS, Antony VB. RSV causes HIF-1alpha stabilization via NO release in primary bronchial epithelial cells. Inflammation. 2004; 28(5): 245-251. doi: 10.1007/s10753-004-6047-y
27. Nasreen N, Mohammed KA, Sanders KL, et al. Pleural Mesothelial cell (PMC) defense mechanisms against malignancy. Oncol Res An Internatl J. 2004; 14(3): 155-161. doi: http://dx.doi.org/10.3727/000000003771013053
28. Nasreen N, Mohammed KA, Antony VB. Silencing the receptor EphA2 suppresses the growth and haptotaxis of malignant mesothelioma cells. Cancer. 2006; 15(107(10)): 2425-2435. doi: 10.1002/cncr.22254
29. Nasreen N, Mohammed KA, Brown S, et al. Tal mediates angiostasis in malignant pleural effusions via endostatin induction in Pleural Mesothelial. Eur Respir J. 2007; 29(4): 761-769. doi: 10.1183/09031936.00061606
30. Nasreen N, Mohammed KA, Hussain T, Antony VB. Receptor EphA2 activation with EphrinA1 Suppresses Growth of Malignant Mesothelioma. Cancer Letters. 2007; 18: 258(2): 215-222. doi: http://dx.doi.org/10.1016/j.canlet.2007.09.005
31. Mohammed KA, Nasreen N, Antony VB. Staphylococcus aureus Induces Differential Expression of C-fos, C-jun and Mediates Apoptosis in Pleural Mesothelial Cells. Lung. 2007; 185(6): 355-365.
32. Mohammed KA, Nasreen N, Tepper RS, Veena B. Antony. Inhibition of P44/42 MAPK Ameliorates Cyclical Stretch induced PlGF release in Bronchial Airway Epithelial Cells. Am J Physiol Lung Cell Mol Physiol. 2007; 292(2): L559-L566.
33. Brown SC, Mohammed KA, Sharma P, Nasreen N, Anthony VB, Moudgil BM. "Influence of Shape, Adhesion and Simulated Lung Mechanics on Amorphous Silica Nanoparticle Toxicity. Advanced Powder Technology. 2007; 18(1): 69-79. doi: 10.1163/156855207779768214
34. Lai YM, Mohammed KA, Nasreen N, Baumuratov A, Bellew BF, Antony VB. Induction of cell cycle arrest and apoptosis by BCG infection in cultured human bronchial airway epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2007; 293(2): L393-L401. doi: 10.1152/ajplung.00392.2006
35. Hussain T, Nasreen, N, Lai Y, Bellew BF, Antony VB, Mohammed KA. Innate Immune Responses in Murine Pleural Mesothelial Cells: TLR2 Dependent Induction of -defensin-2 by Staphylococcal Peptidoglycan. Am J Physiol Cell and Mol Physiol. 2008; 295(3): L461-L470. doi: 10.1152/ajplung.00276.2007
36. Nasreen N, Mohammed KA, Mubarak KK, et al. Pleural mesothelial cell transformation into myofibroblasts and haptotactic migration in response to TGF-1 in vitro. Am J Physiol Cell and Mol Physiol. 2009; 297(1): L115-L124. doi: 10.1152/ajplung.90587.2008
37. Han W, Wang W, Mohammed KA, Su Y. α-Defensins increase lung fibroblast proliferation and collagen synthesis via Wnt/Beta-Catenin pathway. EMBO J. 2009; 276(22): 6603-6614. doi: 10.1111/j.1742-4658.2009.07370.x
38. Montes-Worboys A, Brown S, Regev D, et al. Targeted delivery of amiKA, cin into granuloma. Am J Respir Crit Care Med. 2010; 15(182(12)): 1546-1553. doi: 10.1164/rccm.200912-1888OC
39. Mohammed KA, Wang X, Antony VB, Nasreen N. Silencing receptor EphA2 Induces Apoptosis and attenuate tumor growth in Malignant Mesothelioma. Am J Cancer Research. 2011; 1(3): 419-431.
40. Lee H, Mohammed KA, Goldberg EP, Nasreen N. Targeted lung cancer therapy using ephrinA1-loaded albumin microspheres. J Pharm Pharmacol. 2011; 63(11): 1401-1410. doi: 10.1111/j.2042-7158.2011.01306.x
41. Khodayari N, Mohammed KA, Goldberg EP, Antony VB, Nasreen N. EphrinA1Inhibits Malignant Mesothelioma tumor growth via let-7 microRNA mediated repression of the RAS oncogene. Cancer Gene Therapy. 2011; 18(11): 806-816. doi: 10.1038/cgt.2011.50
42. Nasreen N, Khodayari N, Sukka B, et al . Fluticasone Propionate and Salmeterol Combination Induces SOCS-3 Expression in Airway Epithelial Cells. International Journal of Immuno-pharmacology. 2012; 12(1): 217-225. doi: 10.1016/j.intimp.2011.11.014
43. Mubarak KK, Worboys AM, Regev D, et al. Parenchymal trafficking of pleural mesothelial cells in idiopathic pulmonary fibrosis: Potential role in pathogenesis. Eur Respir J. 2012; 39(1): 133-140. doi:
44. Nasreen N, Khodayari N, Mohammed KA. Advances in Malignant Pleural Mesothelioma therapy: Targeting EphA2 a Novel Approach. Am J Cancer Research. 2012; 2(2): 222-234.
45. Sukka -Ganesh B, Mohammed KA, Ye F, Goldberg EP, Nasreen N. Ephrin-A1 Inhibits NSCLC Tumor Growth via Induction of Cdx-2 a Tumor Suppressor GeneBMC. Cancer. 2012 ; 12(1): 309. doi: 10.1186/1471-2407-12-309
46. Lee HY, Mohammed KA, Goldberg EP, Nasreen N. Arginine-conjugated Albumin Microspheres inhibits Proliferation and Migration in Lung Cancer Cells. Am J Cancer Research. 2013; 3(3): 2156-6976.
47. Lee HY, Mohammed KA, Sharma P, Moudgil BM, William CL, Nasreen N. Targeted delivery of let-7a microRNA encapsulated ephrin-A1 conjugated liposomal nanoparticles inhibit tumor growth in lung cancer. International Journal of Nano-medicine. 2013; 8: 4481-4494. doi: 10.2147/IJN.S41782
48. Lee HY, Mohammed KA, Ye F, et al. Targeted Delivery of Let-7a MicroRNA Encapsulated-EphrinA1 Conjugated Liposomal Nanoparticles Inhibit Tumor Growth in Lung Cancer. Intl. Journal of Nano medicine. 2013; 8: 4481-4494. doi: 10.2147/IJN.S41782
49. Nasreen N, Gonzalves L, Sriram PS, Mohammed KA. Fluticasone furoate is more effective than mometasone furoate in restoring tobacco smoke inhibited SOCS-3 expression in airway epithelial cells. Int Immunopharmacol. 2014; 19(1): 153-160. doi: 10.1016/j.intimp.2013.12.029
50. Nasreen N, Khodayari N, Sriram PS, Patel J, Mohammed KA. Tobacco Smoke induces Epithelial Barrier Dysfunction via Receptor EphA2 Signaling. Am J Physiol Cell Physiol. 2014. doi: 10.1152/ajpcell.00415.2012
51. Yuan Z, Mehta HJ, Mohammed KA, et al. TREM-1 Is Induced in Tumor Associated Macrophages by Cyclo-Oxygenase Pathway in Human Non-Small Cell Lung Cancer. PLoS One.2014; 9(5). doi: 10.1371/journal.pone.0094241
52. Yue Jin, Shenoy AK, Rottiers V, et al. FBXO11 regulates epithelial integrity and homeostasis by targeting Snail transcription factors for degradation. Cell Reports. 2014.

Maher Baz, MD

Clinical Professor of Medicine
Indiana University
Indianapolis, IN, USA

BiographyResearch InterestScientific ActivitiesPublications

Dr. Maher Baz, is a graduate of the American University of Beirut. He trained in Internal Medicine and Pulmonary/Critical Care medicine at Duke University Medical Center from 1989-1995. He joined University of Florida (UF) in 1995 as a lung transplant pulmonologist and was Medical Director of the Lung Transplant Program from 1996-2013. He was tenured at UF in 2002 and promoted to Professor of Medicine in 2010. He joined Indiana University Physicians(UH).Lung Transplant Program in the summer of 2013.

His research interests include lung transplantation, mainly outcomes research, rejection, and oxidative stress.

AWARDS/RECOGNITION


• (1985) Penrose Award. Awarded to one graduate from the class of 1985 of the schools of Arts and Sciences (at the American University of Beirut) “in recognition of the qualities of scholarship, character, and leadership, and contribution of the University as a whole
• (1996) Florida Alpha Award. An annual presentation by the Florida Alpha (alpha one antitrypsin deficiency) Foundation to a physician that contributed most to the health care of patients of the society
• (1997) Certificate of Appreciation. Second Wind Lung Transplant Association, Inc.Our sincere appreciation for your commitment to community service and awareness
• (2001) Boehringer-Ingelheim Young Leaders in Pulmonary Medicine Award. In recognition of young faculty in pulmonary medicine in academic programs in the USA who have demonstrated outstanding qualities as young physician-scientists
• (2003) University of Florida exemplary teacher award. In recognition of clinician’s teaching contributions
• (2005-Present) Recognized in “Marquis Who’s Who in Medicine and Healthcare”
• (2008-Present) “Top Doctor” in Castle and Connolly Medical Ltd
• (2009) Exemplary teacher, Department of Medicine, University of FL


ASSOCIATIONS


• American Thoracic Society (ATS). Member, (1994-present)
• International Society of Heart & Lung Transplantation (ISHLT). Member, (1995-present)
• United Network of Organ Sharing. Member, (1996- present)


COMMITTEES

UNIVERSITY OF FLORIDA (UF) AND SHANDS HOSPITAL (SH)

• Pharmaceutics & Therapeutics Committee. This committee discusses all new medications and decides whether to approve their use by SH pharmacy based on their cost effectiveness and safety profile. If they are approved, it also decides whether to place any restrictions on their use. Member, (03/01-07/2013)
• Shands Hospital committee for guidelines for continuous intravenous Flolan therapy. This committee consisted of me, nurse educators and nurse managers, established guidelines for the inpatient initiation of therapy and the subsequent monitoring of Primary Pulmonary Hypertension patients receiving the continuous intravenous vasodilator, Flolan. Member, (01/00-05/01)
• Weekly Lung Transplant Medical Review Board Meeting. This committee consists of thoracic transplant surgeon, lung transplant nurse coordinators, physical therapist, respiratory therapist, financial advisor, social worker, clinical psychologist, pharmacist and myself. It discusses all potential candidates for lung transplantation and decides whether to place patients on the waiting list or to decline them. Moderator, (1996-present)
• UF/SH Committee for petitioning the Health Care Finance Agency (HCFA). The application submitted by the committee gained approval by HCFA for referral of Medicare patients to the lung transplant program at UF/SH. Moderator, (02/96-04/97)


REGIONAL


• Florida Thoracic Organ Working Group. Organizes annual meeting of thoracic organ transplant programs to formulate guidelines for the allocation of heart and lung organs among the centers in the state of Florida, and to discuss methods to increase the number of thoracic organs utilized in the state. Moderator, 2000. Member, (1998-2006)
• Life Quest Advisory Board. Meets biannually to discuss issues relating to organ procurement, organ management, and education regarding organ donation. Member, (08/04-07/2013)


NATIONAL


• Region 3 Thoracic Organ Representative to the Organ Procurement Transplant Network (OPTN)/ United Network for Organ Sharing (UNOS), Member, (06/04-06/06)
• Alternate representative on the Lung Review Board for the new Lung Allocation System. Transplant Network (OPTN)/ United Network for Organ Sharing (UNOS), (04/05-06/07)
• Joint Subcommittee on Membership criteria Review-Cardiothoracic Group. Transplant Network (OPTN)/ United Network for Organ Sharing (UNOS), (04/05-06/07)


INTERNATIONAL


• Committee for establishing the guidelines for lung transplant candidates. International consortium of lung transplant physicians that established guidelines for appropriate candidates for lung transplantation. The published guidelines have been adopted by the American Thoracic Society (ATS), International Society of Heart and Lung Transplantation (ISHLT), the American Society of Transplant Physicians (ASTP) and the European Respiratory Society (ERS) as their official statement. Member, (01/97)
• Pulmonary council of the International Society of Heart and Lung Transplantation (ISHLT). Members of this council formulate guidelines for lung transplantation, and serve as scientific advisers to ISHLT. Member, (01/00-present)


RESEARCH EXPERIENCE


Investigation of antioxidant lung defenses and oxidative stress during acute rejection in lung allografts. This research was done under the direction of Dr. Claude A. Piantadosi at Duke University Medical Center (1992-1995)

1. Ghassemieh B, Vivek A, Valentine M, et al. Decreased incidence of cytomegalovirus infection with sirolimus in a post hoc randomizedmulticenter study in lung transplantation. J Heart Lung Transplant.2013; 32(7): 701-706. doi: 10.1016/j.healun.2013.04.010
2. Bhorade S, Husain A, Liao C, et al. Interobserver variability in grading transbronchial lung biopsies after lung transplantation. CHEST. 2013; 143(6): 1717-1724. doi: 10.1378/chest.12-2107
3. Hall D, Baz M, Daniels MJ, et al. Immediate postoperative inflammatory response predicts long-term outcome in lung-transplant recipients. Interact Cardiovasc Thorac Surg. 2012; 15(4): 603-607. doi: 10.1093/icvts/ivs330
4. Tonelli A, Timofte I, Minai O, Baz M, Akindipe O. Pulmonary hypertension before first and second lung transplantation. Clin Transplant.2012; 26(5): 672-678. doi: 10.1111/j.1399-0012.2011.01588.x
5. Mubarak K, Worboys A, Akindipe O, et al. Parenchymal trafficking of pleural mesothelial cells in idiopathic pulmonary fibrosis. Eur Respir J. 2012; 39(1): 133-140. doi: 10.1183/09031936.00141010
6. Karimi A, Cobb J, Staples ED, Baz MA, Beaver TM. Technical Pearls for Swine Lung Transplantation. Journal of Surgical Research. 2011; 171: e107-e111. doi: 10.1016/j.jss.2011.05.067
7. Pinney M, Rosenberg AF, Hampp C, Schain D, Akindipe O, Baz M. Invasive Fungal Infections in Lung Transplant Recipients Not Receiving Routine Systemic Antifungal Prophylaxis: 12-Year Experience at a University Lung Transplant Center. Pharmacotherapy . 2011; 31(6): 537-545. doi: 10.1592/phco.31.6.537
8. Martin A, Smith B, Davenport P, et al. Inspiratory muscle strength training improves weaning outcome in failure to wean patients: a randomized trial. Crit Care. 2011; 15(2): R84. doi: 10.1186/cc10081
9. Bussy S, Majid A ,Baz M, et al. Treatment of airway complications following lung transplantation.Arch Bronconeumol.2011; 47(3): 128-133. doi:
10. Ahya V, McShane P, Baz M, et al. Increased Risk of Venous Thromboembolism with a Sirolimus Based Immunosuppression Regimen in Lung Transplantation. J Heart Lung Transplant. 2011; 30(2): 175-181. doi: 10.1016/j.healun.2010.08.010
11. Bhorade S, Ahya V, Baz M, et al. Comparison of Sirolimus with Azathioprine in a Tacrolimus-based immunosuppressive regimen in lung transplantation. Am J Respir Crit Care.2011; 183(3): 379-387. doi: 10.1164/rccm.201005-0775OC
12. Tonelli A, Bussy S, Lodhi S, et al. Prevalence of pulmonary hypertension in end-stage cytic fibrosis and correlation with survival. J Heart Lung Transplant.2010; 29(8): 865-872. doi: 10.1016/j.healun.2010.04.006
13. Akindipe O, Bussy S, Staples E, Baz M. Discrepancies between clinical and autopsy diagnosis in lung transplant recipients. Clin Transplant. 2010; 24(5): 610-614. doi: 10.1111/j.1399-0012.2009.01144.x
14. Akindipe A, Bussy S, Jantz M, et al. Obliterative bronchiolitis in lung allografts removed at retransplant for intractable airway problems.Respirology.2009; 14(4): 601-609. doi: 10.1111/j.1440-1843.2009.01513.x
15. Najmunnisa N, Mohammed K, Mubarak K, et al. Pleural mesothelial cell transformation into myofibroblasts and haptotactic migration in response to TGF- beta1 in vitro. Am J Physiol Lung Cell Mol Physiol. 297(1): L115-1124. doi: 10.1152/ajplung.90587.2008
16. Bussy S, Akindipe O, Kulkarni V, Swafford W, Baz M, Jantz M. Clinical experience with a new removable tracheobronchial stent in the management of airway complications following lung transplantation. J Heart Lung Transplant.2009; 28(7): 683-688. doi: 10.1016/j.healun.2009.04.014.
17. Eagan C, Keller C, Baz M, Thibeault M. Effects of the IV administration of Naloxone on gas exchange in brain dead lung donors: A preliminary report. Progress in Transplantation.2009; 19: 2. doi:
18. Akindipe O, Bussy S, Staples E, Baz M. Late Unilateral Pulmonary Edema in Single Lung Transplant Recipients. Heart Lung Transplant.2008; 27(9): 1055-1058. doi: 10.1016/j.healun.2008.05.026
19. Patel J, Hu H, Lu L, et al. Thioredoxin as a biomarker for graft rejection in lung transplant recipients. Biomarker. 2008; 13(5): 486-495. doi:
20. Akindipe O, Bussy S, Baz M, Staples E. Intraoperative Contralateral Pneumothorax during Single Lung Transplantation. Gen Thorac Cardiovasc Surg. 2008; 56(6): 302-305. doi: 10.1007/s11748-008-0248-5
21. Filichia L, Baz M, Cendan J. Simultaneous Fundoplication and gastric stimulation in a lung transplantrecipient with Gastroparesis and reflux. Journal of the Society of Laparoendoscopic Surgeons.2008; 12(3): 303-305.
22. Akindipe O, Bussy S, Staples E, Baz M. Left pneumonectomy in a patient with a chronically infected allograft. J Heart Lung Transplant. 2007; 26(10): 1072-1074. doi: http://dx.doi.org/10.1016/j.healun.2007.07.015
23. Rodrigue J, Baz M. Waiting for lung transplantation: Quality of life, mood, caregiving strain and benefit, and social intimacy of spouses. Clinical Transplantation. 2007; 21(6): 722-727. doi: 10.1111/j.1399-0012.2007.00729.x
24. Clancy C, Jaber R, Leather H, et al. Bronchoalveolar Lavage Galactomannan in Diagnosis of Invasive Pulmonary Aspergillosis among Solid-Organ Transplant Recipients. J Clin Microbiol.2007; 45: 1759-1765.
25. Braith R, Conner J, Fulton M, et al. Comparison of Alendronate vs Alendronate Plus Mechanical Loading as Prophylaxis for Osteoporosis in Lung Transplant Recipients: a pilot study. J Heart Lung Transplant. 2007; 26(2): 132-137. doi: http://dx.doi.org/10.1016/j.healun.2006.11.004
26. Rodrigue J, Widows M, Baz M. Caregivers of lung transplant candidates:Do they benefit when the patient is receiving psychological services. Progress in Transplantation. 2006; 16(4): 336-342.
26. Mathur A, Baz M, Staples E, et al. Cytokine profile following lung transplantation: correlation with allograft injury. Annals of Thoracic Surgery. 2006; 81(5): 1844-1850. doi: http://dx.doi.org/10.1016/j.athoracsur.2005.11.053
27. Rodrigue J, Baz M. Are There Sex Differences in Health-Related Quality of Life After Lung Transplantation for Chronic Obstructive Pulmonary Disease?. Journal of Heart and Lung Transplantation . 2006; 25: 120-125. doi: http://dx.doi.org/10.1016/j.healun.2005.02.005
32. Zander D, Baz M, Jorgensen M, et al. Bone marrow-derived stem cell repopulation contributes minimally to the type II pneumocyte pool in transplanted human lungs. Transplantation. 2005; 80(2): 206-212.
33. Rodrigue JR, Baz M, Kanasky WF, MacNaughton KL. Does lung transplantation improve health-related quality of life. The University of Florida experience. Journal of Heart and Lung Transplantation. 2005; 24(6): 755-763. doi: http://dx.doi.org/10.1016/j.healun.2004.04.012
34. Rodrigue J, Baz M, Widows M, Ehlers S. A randomized evaluation of Quality of Life Therapy with patients awaitinglung transplantation. American Journal of Transplantation. 2005; 5: 2425-2432. doi: 10.1111/j.1600-6143.2005.01038.x
35. Curran W, Akindipe O, Staples E, Baz M. Lung transplantation for Primary Pulmonary Hypertension and Eisenmengers syndrome. Journal of Cardiovascular Nursing. 2005; 20(2): 124-132.
36. Smith W, Kaplan B, Baz MA, Fann AL, Hatton R. Evaluation of DrugInteraction Software to Identify Alerts for Transplant MedicationsThe Annals of Pharmacotherapy. 2005; 39(1): 45-50. doi:
37. Mitchell M, Baz M, Fulton M, Lisor C, Braith R. Resistance training prevents vertebral osteoporosis in lung transplant recipients. Transplantation. 2003; 76(3): 557-562.
38. Kanasky W, Anton S, Rodrigue J, Perri M, Szwed T, Baz M. Impact of body weight on long-term survival after lung transplantation. CHEST. 2002; 121: 401-406. doi: 10.1378/chest.121.2.401
39. Rodrigue J, Kanasky W, Marhefka S, Perri M, Baz M. A psychometric normative database for pre-lung transplantation evaluations: The Florida cohort 1994-1997. Journal of Clinical Psychology in Medical Settings. 2001; 8: 229-236. br> 40. Palmer S, Baz M, Sanders L, et al. Results of a randomized, prospective, multicenter trial of Mycophenolate mofetil versus Azathioprine in the prevention of acute lung allograft rejection. Transplantation. 2001; 71(12): 1772-1776.
41. Zander D, BAZ M, Visner G, et al. Analysis of early deaths after isolated lung transplantation. CHEST. 2001; 120(1): 225-232. doi: 10.1378/chest.120.1.225
42. Baz M, Palmer S, Staples E, Greer D, Tapson V, Davis R. Lung transplantation after long-term mechanical ventilation: Results and 1 year follow up. CHEST. 2001; 119(1): 224-227. doi: 10.1378/chest.119.1.224
43. Okun M, Nadeau S, Baz M. Lung transplants and paradoxical cerebral emboli. Transplantation. 2000; 70(12): 1805-1806. doi: 10.1097/00007890-200012270-00022
44. Scornik J, Zander D, Baz M, Donnelly W, Staples E. Susceptibility of lung transplants to preformed donor-specific HLA antibodies as detected by flow cytometry. Transplantation. 1999; 68(10): 1542-1546.
45. Zander D, Baz M, Massey J. Patterns and significance of CD44 expression in lung allografts: Correlations with rejection status. J Heart Lung Transplant. 1999; 18(7): 646-653.
46. Aris R, Barbers R, Barst R, et al. International guidelines for the selection of lung transplant candidates. Am J Respir Crit Care Med. 1998; 158(1): 335-339. doi: 10.1164/ajrccm.158.1.15812
47. Baz M, Ghio A, Roggli V, Tapson V, Piantadosi C. Iron accumulation in lung allografts after transplantation. CHEST. 1997; 112(2): 435-439. doi: 10.1378/chest.112.2.435
48. Baz M, Layish D, Govert J, et al. Diagnostic yield of bronchoscopies after isolated lung transplantation. CHEST.1996; 110(1): 84-88. doi: 10.1378/chest.110.1.84
49. Kanj S, Welty K, Madden J, et al. Fungal infections in lung and heart-lung recipients: Report of nine cases and review of the literature. Medicine . 1996; 75(3): 142-156. doi:
50. Baz M, Tapson V, Van T, Roggli V, Piantadosi C. Glutathione depletion in epithelial lining fluid of lung allografts. Am J Respir Crit Care Med. 1996; 153(2): 742-746. doi: 10.1164/ajrccm.153.2.8564127
51. Baz M, Kussin P, Van T, Davis R, Roggli V, Tapson V. Recurrence of diffuse panbronchiolitis after lung transplantation. Am J Respir Crit Care Med. 1995; 151(3): 895-897. doi: 10.1164/ajrccm/151.3_Pt_1.895
52. Baz M, Shararah A. The clinical significance of spontaneous pneumobilia. NC Med J. 1995; 56(8): 1-3.

Urvashi Bhan, MD

Assistant Professor
Department of Internal Medicine
Division of Pulmonary Critical Care
University of Michigan
109 Zina Pitcher Place, 4062 BSRB, SPC 2200
Ann Arbor, MI 48109-2200, USA

BiographyResearch InterestScientific ActivitiesPublications

Dr. Bhan is an Assistant Professor in the Department of Medicine, Division of Pulmonary & Critical Care Medicine at the University of Michigan. She completed her medical education at Topiwalla national Medical College (TNMC) Mumbai, India and went on to do her Internal Medicine residency from University of Hawaii in 2004. She then completed her Pulmonary & Critical Care fellowship at the University of Michigan in 2007. After completing her fellowship she joined the faculty at the University of Michigan to continue her research training and was funded by the NIH/NHLBI T32 Multidisciplinary Training Program in Lung Diseases.

Her research interest is in the field of innate immune response, specifically to bacterial pathogens. Focus of her research is to understand the mechanism of impaired host antibacterial response post viral infection. She is also interested in macrophage biology and its role in host immune response to infection.

HONORS AND AWARDS


• (03/04) Queen Emma Award University of Hawaii Hospitals and Clinics
• (11/04) Employee Recognition Program Youre Super Award University of Michigan Hospitals and Health Centers
• (05/05) Trainee Travel award from AAI committee at ATS
• (04/06) First prize at Michigan Thoracic Society (MTS) poster competition
• (04/07) First prize at MTS poster competition


MEMBERSHIPS IN PROFESSIONAL SOCIETIES


• (2005) Society of Critical Care Medicine
• (2006) American Thoracic Society
• (2010) CHEST


EDITORIAL POSITIONS, BOARDS AND PEER-REVIEW SERVICE


Reviewer


• (2009) Journal of Immunology
• (2009) American Journal of Respiratory and Critical Care Medicine
• (2009) Respiratory Research
• (2010) PLoS One
• (2010) American Journal of Respiratory Cell and Molecular Biology

Peer Reviewed Publications


1. Bhan U, Hyzy RC. Conventional mechanical ventilation. Rose B (ed). Up-to-Date in Pulmonary and Critical Care Medicine. Wellesley, MA (CD-ROM and Website). 2005-2006; 13-14.
2. Bhan U, Lukacs N, OsterholzerJ, et al. TLR9 is Required for Protective Innate Immunity in Gram-negative Bacterial Pneumonia: Role of Dendritic Cells. J Immunol. 2007; 179: 3937-3946. doi: 10.4049/jimmunol.179.6.3937
3. Karaolis DK, Newstead MW, Zeng X, et al. Cyclic di-GMP stimulates protective innate immunity in bacterial pneumonia. Infect Immun. 2007; 75: 4942-4950.
4. Bhan U, Trujillo G, Lyn-Kew K, et al. Toll-like Receptor 9 regulates the lung macrophage phenotype and host immunity in murine pneumonia caused by Legionella pneumophila. Infect Immun. 2008; 76: 2895-2904. doi: 10.1128/IAI.01489-07
5. Bhan U, Cornicelli MD, Standiford TJ. Cytokine networks in the infected lung. Expert Rev. Resp Med. 2008; 2: 739-752. doi: 10.1586/17476348.2.6.739
6. Seki M, Kohno S, Newstead M, Zeng X,et al. Critical role of IL-1 receptor-associated kinase-M in regulating chemokine-dependent deleterious inflammation in murine influenza pneumonia. J Immunol. 2010; 1: 1410-1418. doi: 10.4049/jimmunol.0901709
7. Bhan U, Ballinger MN, Zeng X, Newstead MJ, Cornicelli MD, Standiford TJ. Cooperative interactions between TLR4 and TLR9 regulate interleukin 23 and 17 production in a murine model of gram negative bacterial pneumonia. PLoS One. 2010; 5: e9896. doi: 10.1371/journal.pone.0009896
8. Zhang Y, Wang F, Bhan U, et al. TLR9 signaling is required for generation of the adaptive immune protection in Cryptococcus neoformans infected lungs. Am J Path. 2010; 177: 754-765. doi: 10.2353/ajpath.2010.091104
9. Lyn-Kew K, Rich E, Zeng X, et al. IRAK-M regulates chromatin remodeling in lung macrophages during experimental sepsis. PLoS One. 2010; 5: e11145. doi: 10.1371/journal.pone.0011145
10. Standiford TJ, Kuick R, Bhan U, Chen J, Newstead M, Keshamouni VG. TGF-β-induced IRAK-M expression in tumor-associated macrophages regulates lung tumor growth. Oncogene. 2011; 30: 2475-2484. doi: 10.1038/onc.2010.619
11. Luckhardt TR, Coomes SM, Trujillo G, et al. TLR9-induced interferon β is associated with protection from gammaherpesvirus-induced exacerbation of lung fibrosis. Fibrogenesis. Tissue Repair. 2011; 4: 1-15.
12. Bhan U, Newstead MJ, Zeng X, Ballinger MN, Standiford LR, Standiford TJ. Stachybotrys chartarum-induced hypersensitivity pneumonitis is TLR9 dependent. Am J Pathol. 2011; 179: 2779-2787.
13. Qiu Y, Zeltzer S, Zhang Y, et al. Early induction of CCL7 downstream of TLR9 signaling promotes the robust immunity to cryptococcal infection. J Immunol. 2012; 188(8): 3940-3948. doi: 10.4049/jimmunol.1103053
14. Standiford LR, Standiford TJ, Newstead MW, et al. TLR4-dependent GM-CSF protects against lung injury in Gram-negative bacterial pneumonia. Am J Physiol Lung Cell MolPhysiol. 2011; 302: L447-L454. doi: 10.1152/ajplung.00415.2010
15. Kovach MA, Ballinger MN, Newstead MW, et al. Cathelicidin-related antimicrobial peptide is required for effective lung mucosal immunity in gram-negative bacterial pneumonia. J Immunol. 2012; 189(1): 304-311. doi: 10.4049/jimmunol.1103196
16. Ballinger MN, Newstead MW, Zeng X, et al. TLR signaling prevents hyperoxia-induced lung injury by protecting the alveolar epithelium from oxidant-mediated death. J Immunol. 2012; 189(1): 356-364. doi: 10.4049/jimmunol.1103124
17. Bhan U, Newstead MJ, Zeng X, et al. TLR9-Dependent IL-23/IL-17 is Required for the Generation of Stachybotrys chartarum-induced Hypersensitivity Pneumonitis. J Immunol. 2013; 190(1): 349-356. doi: 10.4049/jimmunol.1202225

Nasreen Najmunnisa, PhD

Research Assistant Professor
Division of Pulmonary Critical Care and Sleep Medicine
College of Medicine, University of Florida
1601 S W Archer Rd
Room: D-106.1 Malcom Randall VA Medical Center
Gainesville, FL, 32608, USA

BiographyResearch InterestScientific ActivitiesPublications

Dr. Nasreen Najmunnisa is a Research Assistant Professor, Division of Pulmonary, Critical Care and Sleep Medicine, College of Medicine, University of Florida, Gainesville, FL.


Education


• (May 1987-Sept 1992) PhD (Physiology and Biochemistry) from Osmania University -Hyderabad, India.
• (Aug 1984-Dec 1986) MS (Zoology), First division with top 3% at Osmania University- Hyderabad, India.
• (June 1981-June 1984) BS. (Biology and Chemistry) First division with distinction, Osmania University - Hyderabad, India.


Research Experience


• (June 2010-Present) Research Assistant Professor, Division of Pulmonary, Critical Care & Sleep Medicine, Department of Medicine, University of Florida, and Gainesville, FL, USA.
• (Oct. 2003-June 2010) Assistant Scientist, Division of Pulmonary, Critical Care & Sleep Medicine, Department of Medicine, University of Florida, and Gainesville, FL, USA.
• (Nov. 1999-Oct 2003) Research Associate, Division of Pulmonary, Critical Care & Occupational Medicine, Indiana University School of Medicine, IUPUI, Indianapolis, IN, USA.
• (July 1996-Nov 1999) Post Doctoral Fellow, Division of Pulmonary, Critical Care & Occupational Medicine, Indiana University School of Medicine, IUPUI, Indianapolis, IN, USA.
• (Sept. 1990-Sept 1992) Senior Research Fellow, Osmania University -Hyderabad, India.
• (May 1987-Sept 1990) Junior Research Fellow, Osmania University -Hyderabad,India.


Her research interests include: Receptor EphA2/EphrinA1 signaling in thoracic malignancies NSCLC & malignant mesothelioma, Micro RNA regulation in thoracic malignancies, Epithelial cell injury and airway remodeling in COPD, Pleural mesothelial epithelial mesenchymal transition in lung fibrosis.

Scientific Honors & Awards


1. Received Best Abstract Award (First place), 2012 Department of Medicine, and University of Florida.
2. Awarded NIR (New Investigator Research Award) –Department of Health, Florida-2009-2012.
3. Excellence in Research Award – 2008, Department of Medicine, University of Florida.
4. Young Investigator Award-2003-2004, American Lung Association.
5. State Merit Scholarship Award -1988, Government of Andhra Pradesh, India.
6. Awarded Meena Pandeyal Gold Medal in Education-1987, Osmania University, and Hyderabad, India.


Membership in Scientific Societies



1. Member of American Thoracic Society
2. Member of American Federation for Medical Research.
3. Member of American Cancer Society


Research & Development – Subcommittees


• 2006-Present: Member, Subcommittee for Research Safety, North Florida/South Georgia Veterans Health Care System, Malcom Randall VAMC, and Gainesville, FL.
• 2007-Present: Member, Institutional Animal Care and Use Committee (IACUC) North Florida/South Georgia Veterans Health Care System, Malcom Randall VAMC, Gainesville, FL.
• 2007-Present: Member, Research Task Force, Division of Pulmonary Critical Care and Sleep Medicine, University of Florida, Gainesville, FL.


Editorial Activities


1. American Journal of Cellular and Molecular Physiology
2. Cancer
3. Inflammation Research
4. Pharmacological Research
5. Molecular Medicine
6. Respirology
7. Cell Biology International
8. PLOS-one
9. American Journal of Cancer research
10. Journal of Nano-medicine


Mentoring & Training

• Hung-Yen Lee, PhD (Post-doctoral Associate) on research project “Gene Therapy for Lung Cancer/Malignant mesothelioma, Division of Pulmonary Critical Care and Sleep Medicine, University of Florida, (Jan, 2012 - present).
• Nazli, Khodayari PhD., (Post doctoral Associate) on research project “EphA2 Signaling in Tobacco Smoke Induced Bronchial Airway Epithelial Injury, Division of Pulmonary Critical Care and Sleep Medicine, University of Florida, (Jan, 2010 – Nov, 2012)
. • Bhagyalaxmi G. Sukka, PhD.,(Post doctoral Associate) on research project” Intra-Tumoral Gene Therapy for Lung Cancer, Division of Pulmonary Critical Care and Sleep Medicine, University of Florida, (Oct., 2010 – June 30th, 2013).
• Hung-Yen Lee, MS (Graduate Student) on research project “ Intra-Tumoral Gene Therapy for Lung Cancer, Division of Pulmonary Critical Care and Sleep Medicine, University of Florida, (Jan, 2010 - 2012).
• Zain Gowani, BS., (Under Graduate Student) on research project “Loss of Autophagic Control: The Precursor to Bronchiolitis Obliterans? Division of Pulmonary Critical Care and Sleep Medicine, University of Florida, (2009-2010).
• Zita, Burkhalter BA., (Laboratory technician) on research project “Suppressor of Cytokine Signaling-3 (SOCS-3) a biomarker for the efficacy of Advair in a murine model of COPD”.
• Division of Pulmonary Critical Care and Sleep Medicine, University of Florida, (2009 June 30th, 2013).
• Mark Vollenweider, M.D., Clinical Fellow, on the research project “Role of BIRC5 (Survivin) in Anchorage Independent Growth of Malignant Mesothelioma”. Division of Pulmonary Critical Care and Sleep Medicine, University of Florida, (2007-2009).
• Xaiohong Wang, BS., (Laboratory technician) on the research project “Role of receptor EphA2 and Ephrins in Malignant mesothelioma growth”. Division of Pulmonary Critical Care and Sleep Medicine, University of Florida, (2004-2009). • Shabnam, Ahmed, BS., (Under Graduate Student) on the research project “Role of receptor EphA2 in Bronchial Airway Epithelial permeability”. Division of Pulmonary Critical Care and Sleep Medicine, University of Florida, (2006-2007).
• Meryl J. Allapattu, BS.,(Under Graduate Student) Cyclical stretch of bronchial smooth muscle cells induces cyclin D1 expression and causes proliferation in p38 MAPK activation dependent manner.(2006-2007).
• Hung-Yen Lee, PhD (Post-doctoral Associate) on research project “Gene Therapy for Lung Cancer/Malignant mesothelioma, Division of Pulmonary Critical Care and Sleep Medicine, University of Florida, (Jan, 2012 - present).

1. Nasreen N, Hartman D, Mohammed K, Antony V. Talc Induces Pleural Mesothelial cell Expression of Proinflammatory Cytokines and Intercellular Adhesion Molecule-1 ICAM-1. Am J Respir Crit Care Med. 1998; 158: 971-978.
2. Mohammed K, Nasreen N, Ward M, Antony V. Macrophage Inflammatory Protein-1alpha: A C-C Chemokine in Parapneumonic Pleural Effusions. J Lab Clin Med. 1998; 1323: 202-209.
3. Mohammed K, Nasreen N, Ward M, Panadero F , Antony V. Mycobacterium Mediated Chemokine Expression in Pleural Mesothelial Cells: Role of C-C Chemokines in Tuberculous Pleurisy. J Infec. Dis. 1998; 178: 1450-1456. doi: 10.1086/314442
4. Nasreen N, Mohammed K, Ward M, Antony V. Mycobacterium-induced transmesothelial migration of monocytes into pleural space: role of intercellular adhesion molecule-1 in tuberculous pleurisy. J Infec. Dis. 1999; 180(5): 1616-1623. doi: 10.1086/315057
5. Mohammed K, Nasreen N, Ward M, Antony V. Helper T-cell type 1 and 2 Cytokines Regulate C-C Chemokine Expression in Mesothelial Cells. Amr J Respir Crit. Care Med. 1999; 159: 1653-1659. doi: 10.1164/ajrccm.159.5.9810011
6. Galffy G, Mohammed K, Ward M, Dowling P, Nasreen N, Antony V. Interleukin-8, an Autocrine Growth Factor for Malignant Mesothelioma. Cancer Research.1999; 59: 367-371.
7. Galffy G, Mohammed K, Nasreen N, Ward M, Antony V. Inhibition of interleukin-8 Reduces Malignant Pleural Mesothelioma Propagation in Nude Mouse Model. Interntl J Oncol. Res. 1999; 11: 187-194.
8. Nasreen N, Mohammed K, Dowling P,Ward M, Antony V. Talc Induces Apoptosis in Human Malignant Mesothelioma in vitro. Amr J Respir Crit Care Med. 2000; 161(2(1)): 595-610. doi: 10.1164/ajrccm.161.2.9904123
9. Nasreen N, Mohammed K, Ward M, Antony V. MCP-1 in pleural injury: CCR2 mediates haptotaxis of pleural mesothelial cells. Am J Physiol - Lung Cellu Mol Physiol. 2000; 278: L591-L598.
10. Mohammed K, Nasreen N, Ward M , Antony V. Induction of Acute Pleural Inflammation by Staphylococcus aureus: I. CD4+ T cells Play a Critical Role in Experimental Empyema. J infec Dis. 2000; 181: 1693-1699. doi: 10.1086/315422
11. Nasreen N, Mohammed K, Hardwick J, et al. Polar production of interleukin-8 by mesothelial cells promotes the transmesothelial migration of neutrophils: role of intercellular adhesion molecule-1. J Infec. Dis. 2000; 183(11): 1638-1645. doi: 10.1086/320700
12. Mohammed K, Nasreen N, Hardwick J, Logie C, Patterson C, Antony V. Bacterial Induction of Pleural Mesothelial Monolayer Barrier Dysfunction. Amr J Physiol-Lung Cellu Mol Physiol. 2001; 281(1): 119-125.
13. Lundien M, Mohammed K, Nasreen N, et al. Induction of MCP-1 Expression in Airway Epithelial Cells: Role of CCR2 Receptor in Airway Epithelial Injury. J Clin Immunol. 2002; 22(3): 144-152.
14. Nasreen N, Mohammed k, Hardwick J, et al. Low molecular weight hyaluronan induces malignant mesothelioma cell (MMC) proliferation and haptotaxis: Role of CD44 receptor in MMC proliferation and haptotaxis. Oncol. Res. 2002; 13(2): 71-78. doi: http://dx.doi.org/10.3727/096504002108748105
15. Loghmani F, Mohammed K, Nasreen N, et al. Cytokines Mediate C-C (Monocyte Chemotactic Peptide) and C-X-C (Interleukin 8) Chemokine Expression in Human Pleural Fibroblasts. Inflammation.2002; 26(2): 73-82.
16. Sriram P, Mohammed K, Nasreen N, et al. Metastatic Ovarian Cancer Increases Pleural Permeability. Oncol Res An Internatl J. 2002; 13(2): 79-85.
17. Mohammed K, Nasreen N, Hardwick J, et al. Mycobacteria Induce Pleural Permeability by Down-Regulating Mesothelial Adherins Junction Proteins. Lung. 2003; 181(2): 57-66.
18. Nasreen N, Mohammed k, Sanders k, et al. Staphylococcus aureus Stimulated Pleural Mesothelial Cells (PMC) Modulate Polymorphonuclear Leukocyte (PMN) Apoptosis. Journal of Clinical Immunology. 2003; 23(1).
19. Sharma R, Mohammed K, Nasreen N, et al. Defensive role of Pleural Mesothelial Cell (PMC) Sialomucins in Tumor Metastasis. Chest. 2003; 124(2): 682-687. doi: 10.1378/chest.124.2.682
20. Nasreen N, Mohammed k, Sanders K, et al. Pleural Mesothelial cell (PMC) defence mechanisms against malignancy. Oncol. Res. An Internatl. J. 2004; 14(3): 155-161. doi: http://dx.doi.org/10.3727/000000003771013053
21. Antony V, Nasreen N, Mohammed K, et al. Talc Pleurodesis. Pleural fluid bFGF predicts outcome of pleurodesis. Chest. 2004; 126(5(1)): 522-528.
22. Kilani MM, Mohammed K, Nasreen N, et al. Respiratory Syncytial Virus Causes Increased Bronchial Epithelial Permeability. Chest. 2004; 126(1): 186-191. doi: 10.1378/chest.126.1.186
23. Kilani MM, Mohammed KA, Nasreen N, Robert S, Tepper, Antony B. RSV Causes HIF-1alpha Stabilization via NO release in Primary Bronchial Epithelial Cells. Inflammation. 2004; 28(5): 245-251. doi: 10.1007/s10753-004-6047-y
24. Icaza G, Mohammed K, Nasreen,N, Horn R, et al. Th2 Cytokines IL-4 and IL-13 Down Regulate Paxillin Expression in Bronchial Airway Epithelial Cells. J Clin Immunol. 2004; 24(4): 426-434.
25. Nasreen N, Mohammed K, Antony V. Staphylococcus aureus Induces Differential Expression of C-fos, C-jun and Mediates Apoptosis in Pleural Mesothelial Cells. Lung. 2007; 185(6): 355-365.
26. Mohammed k, Nasreen N, Tepper R, Antony V. Cyclical stretch induces PlGF expression in bronchial airway epithelial cells via nitric oxide signaling . Am J Physiol. 2007; 292(2): L559-L566.
27. Brown S, Mohammed K, Sharma P, Nasreen N, Antony V, Moudgil B. Influence of Shape, Adhesion and Simulated Lung Mechanics on Amorphous Silica Nanoparticle Toxicity. Advanced Powder Technology.2007; 18(1): 69-79. doi: 10.1163/156855207779768214
28. Nasreen N, Mohammed K, Brown S, et al. Angiogenic balance in Malignant Pleural Effusions: Talc Mediates switch to angiostasis via Endostatin Induction in Pleural Mesothelial Cells Eur. Resp. Journal. 2007; 29(4): 761-769.
29. Scott C, Mohammed K, Nasreen N, et al. Influence of shape, adhesion and simulated lung mechanics on amorphous silica nanoparticle toxicity.Advanced Powder Technology.2007; 18(1): 69-79.
30. Lai Y, Mohammed K, Nasreen N, Baumuratov A, Bellew B, Antony B. Induction of cell cycle arrest and apoptosis by BCG infection in cultured human bronchial airway epithelial cells. Am J Physiol Cell and Mol. Physiol. 2007; 293(2): L393-L401. doi: 10.1152/ajplung.00392.2006
31. Nasreen N, Mohammed K, Antony V. Silencing the receptor EphA2 suppresses the growth and haptotaxis of malignant mesothelioma cells. Cancer. 2006; 107(10): 2425-2435. doi: 10.1002/cncr.22254
32. Nasreen, N, Mohammed K, Antony V. Receptor EphA2 activation with ephrinA1 suppresses growth of malignant mesothelioma (MM). Cancer Lett . 2007; 258(2): 215-222. doi: http://dx.doi.org/10.1016/j.canlet.2007.09.005
33. Hussain T, Nasreen, N, Lai,Bellew B, Antony V, Mohammed K. Innate Immune Responses in Murine Pleural Mesothelial Cells: TLR2 -defensin-2 by Staphylococcal Peptidoglycan. J Am. J Physiol LCMB. 2008; 295(3): L461-L470.
34. Nasreen N, Mohammed k, Antony V . Tgf-beta1 induced epithelial mesenchymal transition in PMC. Am J Physiol Lung Cell Mol. Physiol. 2009; 297(1): L115-L124.
35. Mohammed K, Wang X, Antony V, Nasreen N. Silencing receptor EphA2 Induces Apoptosis and attenuate tumor growth in Malignant Mesothelioma. Am j Cancer Research. 2011; 1(3): 419-431.
36. Mubarak K, Worboys A, Regev D, Nasreen N, et al. Parenchymal trafficking of pleural mesothelial cells in idiopathic pulmonary fibrosis:Potential role in pathogenesis. European Respiratory Journal. 2011.
37. Lee H, Mohammed K, Peruvemba S, Goldberg E, Nasreen N. Targeting Non Small Cell Lung Cancer with EphrinA1 Conjugated Albumin Microspheres. Journal of Pharmacology and pharmacology. 2011. doi: 10.1111/j.2042-7158.2011.01306.x
38. Khodayari N, Mohammed K, Goldberg E, Nasreen N. EphrinA1Inhibits Malignant Mesothelioma tumor growth via let-7 microRNA mediated repression of the RAS oncogene. Cancer Gene Ther. 2011. doi: 10.1038/cgt.2011.50
39. Nasreen N, Khodayar N, Zhang V, Antony V, Pate Vl, Mohammed K. Receptor EphA2 Regulates Barrier function in Tobacco Smoke Exposed Bronchial Airway Epithelial Cells. Cancer. 2012.
40. Nasreen N, Khodayar N, Mohammed K. Advances in Malignant Pleural Mesothelioma Therapy: targeting EphA2 a novel approach. . Am J Cancer Research. 2012; 2(2): 222-234.
41. Ganesh B, Mohammed K, Goldberg E, Nasreen N. Ephrin-A1 Inhibits NSCLC Tumor Growth via Induction of Cdx-2 a Tumor Suppressor Gene. BMC. Cancer. 2012; 12: 309. doi: 10.1186/1471-2407-12-309
42. Mubarak K, Worboys A, Regev D, et al. Parenchymal trafficking of pleural mesothelial cells in idiopathic pulmonary fibrosis. Eur Respir J. 2012; 39(1): 133-140. doi: 10.1183/09031936.00141010.
43. Nasreen N, Khodayari N, Ganesh B, Peruvemba S, Mohammed K. Fluticasone Propionate and Salmeterol Combination Induces SOCS-3 Expression in Airway Epithelial Cells. International Journal of Immuno pharmacology. 2012; 12(1): 217-222. doi: 10.1016/j.intimp.2011.11.014
44. Lee H, Mohammed K, Goldberg E, Nasreen N. Arginine-conjugated albumin microspheres inhibits proliferation and migration in lung cancer cells. Am J Cancer Res. 2013; 3(3): 266-277.
45. Lee HY, Mohammed KA, Kaye F, et al. Targeted delivery of let-7a microRNA encapsulated ephrin-A1 conjugated liposomal nanoparticles inhibit tumor growth in lung cancer. Int J Nanomedicine. 2013; 8: 4481-4494. doi: 10.2147/IJN.S41782
46. Nasreen N, Gonzalves L, Peruvemba S, Mohammed K. Fluticasone furoate is more effective than mometasone furoate in restoring tobacco smoke inhibited SOCS-3 expression in airway epithelial cells Int. Immunopharmacol. 2014; 19(1): 153-160. doi: 10.1016/j.intimp.2013.12.029

Zhaolin Xu, MD, FRCPC, FCAP

Professor, Dept. of Pathology, Dalhousie University
Pulmonary Pathologist and Cytopathologist, QE II Health Sciences Centre
Senior Scientist, Beatrice Hunter Cancer Research Institute
5788 University Ave
Halifax NS B3H 1V8, Canada

BiographyResearch InterestScientific ActivitiesPublications

Dr. Xu is a leading expert in pulmonary pathology in the Atlantic Canada. He graduated from Shanghai Medical University (Shanghai Medical College, Fudan Univresity) in China in 1982 and did thoracic surgical oncology residency there. He moved to Canada in 1987 as a postdoctoral research fellow, and completed pathology residency in the Dalhousie University in 1997. He obtained the fellowship certifications from both Royal College of Physicians and Surgeons of Canada and American Board of Pathology.
He is not only an expert in pulmonary pathology and cytopathology, he is also a cancer researcher and holds the position of Senior Scientist in the Beatrice Hunter Cancer Research Institute, Canada.
He has obtained research grants from various sources. Currently he is the Expert Panel Member in the Lung National Cancer Pathology and Staging Multidisciplinary Expert Panel, Canadian Partnership Against Cancer (CPAC). He is also the Chair, Pathology Working Group and Network Member, Pan-Canadian Lung Cancer Screening Network, CPAC, and the Chair, Pathology Working Group and Steering Committee Member, Lung Cancer Screening Network, Cancer Care Nova Scotia (CCNS), Canada.
In addition he holds memberships in the Correlative Sciences and Tumor Biology Committee and Lung Cancer Subcommittee in the National Cancer Institute of Canada (NCIC), and Medical Advisory Committee Member, Lung Cancer Canada (LCC). Dr. Xu’s research interest includes studying molecular profiling of human lung cancer in addition to pathological assessment of the tumor and selecting patients to receive personalized targeted therapy.
Dr. Xu and his colleagues established the QE II Lung Tumor Bank for research. Dr. Xu is the Director of the tumor bank which is one of the largest human lung tumor banks in the country and is certified by the Canadian Tumor Repository Network (CTRNet).

His research interests include: Lung cancer genotyping and Molecular profiling, Lung tumor banking, Metastasis and Early detection of lung cancer, Interstitial lung diseases.

ACADEMIC COMMITTEE MEMBER AND ADMINISTRATION


• (2014-now) Committee Member, Medical Advisory Committee, Lung Cancer Canada
• (2014-now) Committee Member, Lung Cancer Screening Steering Committee, Cancer Care Nova Scotia, Halifax, NS Canada
• (2014-now) Chair, Pathology Working Group, Lung Cancer Screening Program, Cancer Care Nova Scotia, Halifax, NS Canada
• (2013-Present) Chair, Pathology Working Group, The Pan-Canadian Lung Cancer Screening Network, Canadian Partnership Against Cancer, Canada
• (2013-Present) Committee Member, The Pan-Canadian Lung Cancer Screening Network, Canadian Partnership Against Cancer, Canada
• (2011-Present) Expert Panel Member, Lung National Cancer Pathology and Staging Multidisciplinary Expert Panel, Canadian Partnership Against Cancer, Canada
• (2007-Present) Committee Member, Correlative Sciences and Tumor Biology Committee, National Cancer Institute of Canada, Canada
• (2007-Present) Committee Member, CSTB-Lung Subcommittee, National Cancer Institute of Canada, Canada
• (2006-Present) Committee Member, Capital Health Research Ethics Board, Halifax, Canada
• (2006-Present) Committee Member, Mesothelioma and Thymoma Working Group, Lung Disease Site Committee, National Cancer Institute of Canada, Canada
• (2004-2005) Board of Directors, University Avenue Laboratory Medicine Association, Queen Elizabeth II Health Sciences Centre, Halifax, Canada
• (2002-2003) Chair, Anatomical Pathology and Cytology Standards Committee, Winnipeg Regional Health Authority, Winnipeg, Canada
• (2002-2003) Committee Member, Laboratory Medicine Standards Committee, Winnipeg Regional Health Authority, Winnipeg, Canada
• (2001-2003) Committee Member, Pathology Tissue Assessing Committee, Department of Pathology, University of Manitoba, Winnipeg, Canada
• (2002-2003) Committee Member, Clinical Oncology Standards Committee, Winnipeg Regional Health Authority, Winnipeg, Canada
• (1996-1997) Chief Resident, Pathology Residency Program, Dalhousie University, Halifax, Canada
• (1986-1987) Academic Secretary, Shanghai Lung Cancer Group, Shanghai Division of Chinese Medical Association, China

1. MacNeil A, Jiao S, Eachern L, et al. MAPK kinase 3 is a tumor suppressor with reduced copy number in breast cancer. Cancer Research. 2014; 74(1): 162-172.
2. Yeung P, Xu Z, Seeto D. Diltiazem Reduces Mortality and Breakdown ofATP in Red Blood CellInduced by Isoproterenol in a Freely Moving Rat. Model in Vivo Metabolites. 2014; 4: 775-789. doi: 10.3390/metabo4030775
3. Alcolado N, Conrad DJ, Poroca D, et al. Cystic Fibrosis Transmembrane Conductance Regulator dysfunction in VIP knockout mice. American Journal of Physiology Cell Physiology 2014. doi: 10.1152/ajpcell.00293.2013
4. Cressman S, Lam S, Tammemagi M, et al. Resource Utilization and Costs during the Initial Years of Lung Cancer Screening with Computed Tomography in Canada. Journal of Thoracic Oncology. 2014.
5. Xu Z. Genomics and Molecular Profiling of Lung Cancer in Cancer Genomics:from bench to personalized medicine. Eds. Dellaire G,Berman J, Arceci R.Academic Press, Elsevier. 2013.
6. Xu Z. Pulmonary Pathology in Pathology Review ed. Zu-Hua Gao.BrushEducarion Inc.2013.
7. Vieira A ,Xu Z, Colp P, Marignani PA. Loss of lkb1 expression reduces the latency of ErbB2-mediated mammary gland tumorigenesis, promoting changes in metabolic pathways.Plos One 2013; 8(2): e56567. doi: 10.1371/journal.pone.0056567
8. Marrie T, Costain N, Scola B, et al. The role of atypical pathogens in community-acquired pneumonia. Semin Respir Crit Care Med. 2012; 33(3): 244-256. doi: 10.1055/s-0032-1315636
9. Henzler D, Hochhausen H, Chankalal R, et al. Physiologic and biologic characteristics of three experimental models of acute lung injury in rats.Anesthesia and Analgesia. 2011; 112(5): 1139-1146. doi: 10.1213/ANE.0b013e3182104dac
10. Bethune G, Bethune D, Ridgway N, Xu Z. Epidermal growth factor receptor (EGFR) in lung cancer: an overview and update. The Journal of Thoracic Disease. 2010; 2: 48-51.
11. Xu Z, Bethune D, Manos D, et al. Pulmonary Hyalinizing Granuloma. Journal of Peking University (Health Sciences).2009; 41(4): 252-257.
12. Naugler C, Xu Z. Pancreatic adenoc arcinoma metastatic to the pineal gland. Journal of Clinical Neuroscience. 2008; 15: 1284-1286. doi: 10.1016/j.jocn.2007.08.022
13. Douglas SE, Bethune DC, Xu Z. Microarray analysis identifies pathways in progression of early stage lung adenocarcinoma: the importance of focal adhesion and ECM-receptor interactions. Pulm Res Respir Med Open J. 2014; 1(1): 21-31. 10.17140/PRRMOJ-1-104
14. Xu Z. Significance of molecular genotyping for lung cancer in modern oncology. Pulm Res Respir Med Open J. 2015; 2(3): 120-121. doi: 10.17140/PRRMOJ-2-119

Douglas S. Gardenhire, EdD, RRT-NPS, FAARC

Governor’s Teaching Fellow
Director of Clinical Education
Lewis School of Nursing and Health Professions
Department of Respiratory Therapy
Georgia State University
PO Box 4019
GA 30302-4019, Atlanta, USA

BiographyResearch InterestScientific ActivitiesPublications

Dr. Douglas S. Gardenhire is the Director of Clinical Education for the Respiratory Therapy Program at Georgia State University. He is the author of Rau’s Respiratory Care Pharmacology, lead author for the AARCs Guide to Aerosol Delivery Devices for Respiratory Therapist, chapter author on Airway Pharmacology for Egan’s Fundamentals of Respiratory Care, as well as chapter author on Airway Pharmacology and Delivery of Aerosol Drug Therapy in Respiratory Care Clinical Lab Competency Manual. Dr. Gardenhire has authored a number of peer-reviewed articles on respiratory care education and aerosol medication. His research interests continue to focus on respiratory care education and trends, pharmacology, and aerosol product evaluation. He is a fellow of the AARC and was has been recognized as Educator of the Year in 2012.

His research interests includes: Aerosol Medicine, Pharmacology, Pulmonary Trends in Healthcare Careers, and Correlation of Student Achievement.

AWARDS AND HONORS

• (2013) William and AlleneGutherie Van Meter Outstanding Alumni Achievement Award. Labette Community College Foundation
• (2012) Fellow, American Association for Respiratory Care
• (2012) Educator of the Year, American Association for Respiratory Care
• (2012) Nominated, Top 40 Under 40, University of Georgia Alumni Association
• (2012) Governor’s Teaching Fellow, University System of Georgia
• (2009-2010) Scholar Fellow, Center for Teaching and Learning, Georgia State University
• (2006) Allen DeVilbiss Technology Paper Award. American Respiratory Care Foundation
• (2002) Outstanding Clinical Instruction, Labette Community College

Journal Articles (Data-based)

Published Referred Journal Articles

1. Gardenhire DS. Aerosol Delivery for the Mechanical Ventilation Patient. AARC Times. 2013; 37(8): 11-14.
2. Gardenhire DS. Side Effects of Commonly Used Respiratory Medications. AARC Times 2013; 37(8): 28-30.
3. Zimmerman R, Gardenhire DS. The History and Impact of Mandatory Student Health Insurance. Respiratory Care Education Annual. 2012; 21: 35-42.
4. Rivera C, Gardenhire DS. Aplasia - Congenital Lung Abnormality with Non-Development. The Internet Journal of Allied Health Sciences and Practice. 2012; 10(2).
5. Ari A, Goodfellow LT, Gardenhire DS. Admission Criteria As Predictors of Student Success on the National Board for Respiratory Care Examinations. Respiratory Care Education Annual 2008; 17: 1-6.
6. Ling H, Restrepo RD, Gardenhire DS, Rau J. An in vitro investigation of nebulized albuterol delivery by facemask to spontaneously breathing infants. Respir Care. 2007; 52(8): 1021-1026.
7. Restrepo RD, Gardenhire DS. Correlation Between Number of Hits to WebCT Respiratory Care Courses and Student Performance . Respiratory Care Education Annual. 2006; 15: 41-48.
8. Gardenhire DS, Restrepo RD. Correlational Study of Predictor Variables for Program Completion in an Associate Degree Respiratory Care Program. Respiratory Care Education Annual. 2003; 12: 21-28.
9. Ari A, Gardenhire DS, Goodfellow LT. Identifying Factors of Grading Practices Influencing Students Evaluation of Clinical Instructors. Respiratory Care Education Annual. 2006; 15: 31-40.
10. Dickson SK, Restrepo RD, Rau J, Gardenhire DS. An In Vitro Investigation of Two Techniques for Nebulizer Delivery in Spontaneously Breathing Pediatric Subjects. Respir Care. 2006; 51(1): 56-61.

Li Feng, MD, PhD

Attending Phyisician
Department of Respiratory medicine
The First People’s Hospital of Shanghai JiaoTong University
100, Haining Road, Shanghai, 200080, PR, China

BiographyResearch InterestScientific ActivitiesPublications

Dr. Li finished his bachelor study and master study at Anhui Medical University and then obtained his PhD degree in 2010 at Shanghai Jiao Tong University, which was jointly trained at Shanghai Jiao Tong University and NHLI/Imperial College. He then completed his postdoc training at NHLI/Imperial College between 2011 and 2012, which was supported by European Respiratory Society. He is now an attending Physician at Shanghai First People’s Hospital, Shanghai Jiao Tong University. He has authored and co-authored a number of papers. His studies are supported by Shanghai Health Department, Shanghai Science Council, National Science Foundation of China.

His research interests includes: The mechanism of chronic airway disease(asthma and COPD), especially on the effects and mechanisms of air pollutants triggered airway disease exacerbation.

REWARDS:

Research on the related mechanism of bronchial asthma and standardized treatment: Third Price, Awarding Committee of Shanghai Medical Science and Technology (2011)


PROFESSIONAL MEMBERSHIP

• (2010) Silver member under 35 of European Respiratory Society
• (2011) Member of Chinese Medical Association

Original papers (In English)


1. Zhang P, Li F, Wiegman CH, et al. Inhibitory Effect of Hydrogen Sulfide on Ozone-induced Airway Inflammation, Oxidative Stress and Bronchial Hyperresponsiveness. Am J Respir Cell Mol Biol. 2014.doi: 10.1165/rcmb.2013-0415OC
2. Wiegman CH, Li F, Clarke CJ, et al. A comprehensive analysis of oxidative stress in the ozone-induced lung inflammation mouse model. Clin Sci (Lond) . 2014; 126: 425-440. doi: 10.1042/CS20130039
3. Li F, Wiegman C, Seiffert JM, et al. Effects of N-acetylcysteine in ozone-induced model of chronic obstructive pulmonary disease. PLoS ONE. 2013; 8: e80782. doi: 10.1371/journal.pone.0080782
4. Liang L, Li F, Bao A, Zhang M, Chung KF, Zhou X. Activation of p38 mitogen-activated protein kinase in ovalbumin and ozone-induced mouse model of asthma. Respirology. 2013; 18 Suppl3: 20-29. doi: 10.1111/resp.12189
5. Bao A, Liang L, Li F, Zhang M, Zhou X. Effects of acute ozone exposure on lung peak allergic inflammation of mice. Front Biosci. 2013; 18: 838-851.
6. Pinart M, Zhang M, Li F, et al. IL-17A modulates oxidant stress-induced airway hyperresponsiveness but not emphysema. PLoS One. 2013; 8: e58452. doi: 10.1371/journal.pone.0058452
7. Triantaphyllopoulos K, Hussain F, Pinart M, et al. A model of chronic inflammation and pulmonary emphysema after multiple ozone exposures in mice. Am J Physiol Lung Cell Mol Physiol. 2011; 300: L691-L700.doi: 10.1152/ajplung.00252.2010
8. Li F, Zhang M, Hussain F, et al. Inhibition of p38-MAPK-dependent bronchial contraction after ozone by corticosteroids. Eur Respir J. 2011; 37: 933-942. doi: 10.1183/09031936.00021110
9.Zhang P, Zhou X, Li F. Hydrogen sulfide in airway diseases. Pulm Res Respir Med Open J. 2015; 2(2): 81- 83. doi: 10.17140/PRRMOJ-2-113


Original papers (In Chinese)


1. Li Feng, Pengyu Z, Min Z, et al. The effects of acute and chronic ozone exposure on inflammation, structure and function in murine lung. Chinese Journal of Respiratory and Critical Care Medicine. 2014; 13(3): 295-299.
2. Feng L, Min Z, Xin Z. Effect of p38 MAPK inhibitor SB239063 on TNF-alpha mediated enhanced bronchial smooth muscle contractility.(in Chinese) Clinical Pulmonary Journal. 2010; 15(9): 1222-1224.
3. Li Z, xia QZ, Feng L, Rongyu L. The effect of Melatonin on the regulation of collagen accumulation and Matrix metalloproteinase -9 and tissue inhibitor of matrix metalloproteinase -1 mRNA and protein in a murine model of chronic asthma. (in Chinese) Chinese Journal of Tuberculosis and Respiratory Disease. 2007; 30(7): 527-532.
4. Feng L, Rongyu L. Airway inflammtion and remodeling in murine model of chronic asthma and the effects of dexamethasone. (in Chinese) Chinese Journal of Respiratory and Critical Care Medicine. 2005; 4(2): 110-114.


Review articles ( In Chinese)


1. Feng L, Min Z, Xin Z. Oxidative stress in airway disease. Chinese Journal of Respiratory and Critical Care Medicine. 2012; 11(1): 97-100.
2. Hua BA, Feng L, Min Z, Xin Z. Development in molecular mechanisms of glucocortcoid-resistant asthma. International Journal of Respiratory Medicine. 2011; 31(9): 696-699.
3. Feng L, Xin Z. P38 MAPK and chronic airway disease. International Journal of Respiratory Medicine. 2010; 30(15): 944-947.
4. Feng L, Enhai C, Xin Z. The nerve growth factor and bronchial asthma. International Journal of Respiratory Medicine. 2009; 29(7): 422-425.

Robert M. Aris, MD

Professor of Medicine
Division of Pulmonary and Critical Care Medicine
University of North Carolina at Chapel Hill
CB 7020, Room 4131, Bioinformatics Building
130 Mason Farm Rd
Chapel Hill, NC 27599
USA

BiographyResearch InterestScientific ActivitiesPublications
EDUCATIONAL QUALIFICATIONS

• (1976-1980) Jacksonville University, BA, Biology and Chemistry Valedictorian (straight As for all classes)
• (1980-1984) Vanderbilt University, MD
• (1984-1987) University of Colorado, Denver Resident, Internal Medicine
• (1987-1990) University of California, San Francisco: Fellowships, Pulmonary and Critical Care Medicine and the Cardiovascular Research Institute


PROFESSIONAL EXPERIENCES


• (2013-Present) Pulmonary Consultant, Central Carolina Hospital Sanford, NC
• (2011-2014) Pulmonary Consultant, Rex Hospital, Raleigh, NC
• (2011-Present) Pulmonary Consultant, UNC Physicians Network, Sanford, NC
• (8/2010-Present) Professor of Medicine, University of North Carolina
• (2002-2012) Co-Director, Pulmonary Hypertension Program UNC
• (2000-2010 ) Director, Lung Transplantation Immunology Laboratory
• (1999-2010) Associate Professor of Medicine (with tenure), University of North Carolina
• (1998-2004) Medical Director, Lung Transplantation Program, UNC
• (1994-2004) Director, Inpatient Pulmonary Medicine Service, UNC
• (1993-1999) Assistant Professor of Medicine, The University of North Carolina
• (1990-1993) Assistant Professor of Medicine, University of California, San Francisco, Chief, Chest Clinic, San Francisco General Hospital, UCSF

His research interests includes clinical and translational research in the fields of Lung transplantation, cystic fibrosis and Pulmonary hypertension.

HONORS AND AWARDS


• Presidents Scholarship (full academic scholarship), 1976-80; given to one graduating senior from each high school in Jacksonville FL based on academic performance
• Phi Kappa Phi Scholarship, 1980
• Biology Student of the Year, 1979
• Chemistry Student of the Year, 1980
• American Tae Kwon Do Association Black Belt, 1st degree, decided, 1980
• Alpha Omega Alpha Medical Honor Society, 1983; eligible to graduates in the top 15% of the class after an affirmative vote by our peers
• Listed in Guide to Americas Top Physicians by Consumers Research Council of America, 2005. 2011, 2013, 2014
• Madisons Whos Who, 2003-present
• Covingtons Whos Who 2014


MEMBERSHIPS

• American Thoracic Society
• North Carolina Thoracic Society
• American Society of Transplantation
• International Society of Heart and Lung Transplantation
• Alpha Omega Alpha

Journal Articles


1. Aris R, Christian D, Sheppard D, Balmes J. Acid fog induced bronchoconstriction: the role of hydroxymethanesulfonic acid. Am Rev of Respir Dis. 1990; 141: 546-551. doi: 10.1164/ajrccm/141.3.546
2. Aris R, Christian D, Sheppard D, Balmes J. The effects of sequential exposure to acidic fog and ozone on pulmonary function in exercising subjects. Am Rev of Resp Dis. 1991; 143: 85-91. doi: 10.1164/ajrccm/143.1.85
3. Aris R, Christian D, Sheppard D, Balmes J. Lack of bronchoconstrictor response to sulfuric acid aerosols and fogs. Am Rev Resp Dis. 1991; 143: 744-750. doi: 10.1164/ajrccm/143.4_Pt_1.744
4. Aris R, Christian D, Finkbeiner W, Balmes J . The effects of nitric acid vapor alone, and in combination with ozone, on healthy volunteers. Am Rev Resp Dis. 1993; 148: 965-973. doi: 10.1164/ajrccm/148.4_Pt_1.965
5. Aris R, Christian D, Hearne P, Kerr K, Finkbeiner W, Balmes J . Ozone-induced airway inflammation in human subjects as assessed by airway lavage and biopsy. Am Rev Resp Dis. 1993; 148: 1363-1372. doi: 10.1164/ajrccm/148.5.1363
6. Erle D, Brown T, Christian D, ArisR. Lung epithelial lining fluid T cell subsets have distinct patterns of 7 and 1 integrin expression. Am J Respir Cell Mol Bio. 1994; 10: 237-242. doi: 10.1165/ajrcmb.10.3.7509610
7. Aris R, Christian D, Hearne P, et al. Methacholine responsiveness is not associated with ozone-induced decrements in FEV1. Chest. 1995; 107: 621-628.
8. Egan TM, Thompson J, Detterbeck F, et al. Effect of size (mis)matching in clinical double-lung transplantation. Transplantation. 1995; 59: 707-713.
9. Balmes J, Chen L, Scannell C, et al. Ozone-induced decrements in FEV1 and FVC do not correlate with measures of inflammation. Am J RespCrit Care Med. 1996; 153: 904-909. doi: 10.1164/ajrccm.153.3.8630571
10. Aris R, Neuringer I, Egan T, Weiner M, Ontjes D. Severe osteoporosis before and after lung transplantation. Chest. 1996; 109: 1176-1183. doi: 10.1378/chest.109.5.1176
11. Scannell C, Chen LL, Aris RM, et al. Greater ozone-induced inflammatory responses in subjects with asthma. Am J RespirCrit Care Med. 1996; 154: 24-29. doi: 10.1164/ajrccm.154.1.8680687
12. Donaldson S, Novotony D, Paradowski L and ArisRM. Acute and chronic lung allograft rejection during pregnancy. Chest. 1996; 110: 293-296. doi: 10.1378/chest.110.1.293
13. Aris RM, Maia D, Neuringer I, et al. Post-transplantation lymphoproliferative disorder in the Epstein-Barr virus-naïve lung transplant recipient. Am J Respir Crit Care Med. 1996; 154: 1712-1717. doi: 10.1164/ajrccm.154.6.8970360
14. Stang M, Hinderliter A, Gott K, Paradowski L, Aris RM. Atrial anastomotic thrombus causing reversible neurologic deficits after lung transplantation. Transplantation. 1996; 62: 693-695.
15. Aris RM. Osteoporosis in patients undergoing lung transplantation. Chest. 1997; 111: 257-258.
16. Aris RM, Gilligan P, Neuringer I, Gott K, Rea J, Yankaskas JR. The effects of panresistant bacteria in cystic fibrosis patients on lung transplant outcome. Am J Respir Crit Care Med. 1997; 155: 1699-1704. doi: 10.1164/ajrccm.155.5.9154879
17. Fitzsimons E, Aris RM, and Patterson R. Recurrence of ABPA in the post-transplant lungs of a cystic fibrosis patient. Chest. 1997; 112: 281-283. doi: 10.1378/chest.112.1.281
18. Balmes J, Aris R, Chen L, et al. Effects of ozone on normal and potentially sensitive subjects. Part I: airway inflammation and respon-siveness to ozone in normal and asthmatic subjects. Research Report-Health Effects Institute. 1997; 78: 1-37.
19. Aris R, Renner J, Winders A, et al. Increased fractures and severe kyphosis: sequelae of living into adulthood with cystic fibrosis. Ann Int Med. 1998; 128: 186-193. doi: 10.7326/0003-4819-128-3-199802010-00004
20. Aris R, Barbers R, Barst R, et al. International guidelines for the selection of lung transplant candidates. Am J RespirCrit Care Med. 1998; 158: 335-339. doi: 10.1164/ajrccm.158.1.15812
21. Neuringer I, Mannon R, Coffman T, Burns K, Yankaskas J, Aris R. Immune cells in the mouse airway model of obliterative bronchiolitis. Am J Respir Cell Mol Bio. 1998; 19: 379-386. doi: 10.1165/ajrcmb.19.3.3023m
22. Egan T, Detterbeck F, Mill M, et al. Lung transplan-tation for cystic fibrosis: effective and durable therapy in a high-risk group. Ann ThoracSurg. 1998; 66: 337-346. doi: http://dx.doi.org/10.1016/S0003-4975(98)00496-2
23. Aris R, Lester G, OntjesD. Bone loss physiology in the chronically critically ill. Chest. 1998; 114: 954-955.
24. Aris R, Lester G, Dingman S, Ontjes D. Altered calcium homeostasis in adults with cystic fibrosis. Osteoporosis International. 1999; 10(2): 102-108.
25. Neuringer I, Walsh S, Mannon R, Gabriel S, Aris R. Enhanced T-cell cytokine gene expression in mouse airway obliterative bronchiolitis. Transplantation. 2000; 69: 399-405.
26. Aris R, Lester G, Renner J, et al. Efficacy of pamidronate for osteoporosis in cystic fibrosis patients following lung transplantation. Am J Respir Crit Care Med. 2000; 162: 941-946. doi: 10.1164/ajrccm.162.3.2002051
27. Aris R, Stevens A, Ontjes D, et al. Adverse alterations in bone metabolism are associated with lung infection in adults with cystic fibrosis. Am J Respir Crit Care Med. 2000; 162(5): 1674-1678. doi: 10.1164/ajrccm.162.5.2002100
28. Yankaskas J, ArisR. Outpatient Care of Cystic Fibrosis Patient after Lung Transplantation. CurrOpin in Pulm Med. 2000; 6(6): 551-557.
29. Gilbey J, Chalermskulrat W, Aris R. Aspergillus endocarditis in a lung transplant recipient: case report and review of the transplant literature. Annals of Transplantation. 2000; 5(3): 48-53.
30. Lark R, Lester G, Ontjes D, et al. Diminished and erratic absorption of ergocalciferol in adult cystic fibrosis patients. Am J Clin Nutr. 2001; 73(3): 602-606.
31. Aris R, Routh J, LiPuma J, Heath D, Gilligan P. Lung transplantation for cystic fibrosis patients with Burk-holderia cepacia complex: survival linked to genomovar type. Am J RespirCrit Care Med. 2001; 164: 2102-2106. doi: 10.1164/ajrccm.164.11.2107022
32. Aris R, Ontjes D, Buell H, et al. Abnormal bone turnover in cystic fibrosis adults. Osteoporosis Int. 2002; 13(2): 151-157.
33. Heath D, Hohneker K, Curriker C, et al. A six-year molecular analysis of Burkholderiacepacia isolates among cystic fibrosis patients at a referral center for lung transplantation. J ClinMicrobiol. 2002; 40(4): 1188-1193. doi: 10.1128/JCM.40.4.1188-1193.2002
34. Neuringer I, Aris R, Burns K, Bartolotta T, Chalermskulrat W, Randell S. Epithelial Cell Kinetics in Mouse Tracheal Allografts. Am J Transplantation. 2002; 2: 410-419. doi: 10.1034/j.1600-6143.2002.20503.x
35. Aris R, Walsh S, Chalermskulrat W, Hathwar V, Neuringer I. Growth factor upregulation during obliterative bronchiolitis in the mouse model. Am J RespirCrit Care. 2002; 166(3): 417-422. doi: 10.1164/rccm.2102106
36. Aris R. Pathogenesis of CF bone disease. Ped Pulmonol. 2002; 24: 177-178.
37. Egan T, Detterbeck F, Mill M, et al. Long term results of lung transplantation for cystic fibrosis. Eur J CardiothoracSurg. 2002; 22(4): 602. doi: 10.1016/S1010-7940(02)00376-7
38. Aris R. Complications after lung transplantation: clues to diagnosis. J Crit Illness. 2003; 18(2): 52-53.
39. Chalermskulrat W, Neuringer I, Brickey J, et al. Hierarchical Contributions of Allorecognition Pathways in Chronic Lung Rejection. Am J Respir Crit Care Med. 2003; 167: 999-1007. doi: 10.1164/rccm.200209-1099OC
40. Chalermskulrat W, Neuringer I, Schmitz J, Gurka M, Randell S, Aris R. Human leukocyte antigen mismatches predispose to the severity of bronchiolitis obliterans syndrome after lung transplantation. Chest. 2003; 123: 1825-1831. doi: 10.1378/chest.123.6.1825
41. Brown S, Ontjes D, Lark R, et al. Short-term calcitriol administration improves calcium homeostasis in adults with CF. Osteoporosis Int. 2003; 14(5): 442-449. doi: 10.1007/s00198-002-1331-x
42. Aris R, Brown S, Ontjes D, Chalermskulrat W, Neuringer I, Lester G. Carboxylated Osteocalcin Levels in Cystic Fibrosis. Am J Respir Crit Care Med. 2003; 168(9): 1129. doi: 10.1164/ajrccm.168.9.950
43. Aris R, Lester G, Camaniti M, et al. Efficacy of Alendronate in Cystic Fibrosis Adults with Low Bone Density. Am J RespirCrit Care Med. 2004; 169: 77-82. doi: 10.1164/rccm.200307-1049OC
44. Hecker T, Aris R. Management of osteoporosis in adults with cystic fibrosis. Drugs. 2004; 64 (2): 133-147.
45. Charlermskulrat W, Neuringer I, Park R, et al. PX3.102, a Novel Chinese Herb Extract, Diminishes Chronic Airway Allograft Rejection. Transplantation. 2004; 78(1): 158-161.
46. Tullis E, Aris R. Timing of Referral for Lung Transplant: Coordination Between the CF Center and Lung Transplantation Centers. Ped Pulmonol. 2004; 27: 176-177.
47. Aris R, Lester G, Ontjes D. Treatment of bone disease in cystic fibrosis. Cur Opin in Pulm Med. 2004; 10(6): 524-530.
48. Aris R, Donohue J, Ontjes D. Inhaled corticosteroids and fracture risk: Having our cake and eating it too. Chest. 2005; 127(1): 5-7. doi: 10.1378/chest.127.1.5
49. Aris R, Guise T. Cystic Fibrosis and Bone Disease: Are We Missing a Genetic Link. EurRespir J. 2005; 25(1): 9-11. doi: 10.1183/09031936.04.00125804
50. Aris R, Merkel P, Bachrach L, et al. Review of a consensus conference report: Guide to Bone Health and Disease in Cystic Fibrosis. J Clin Endocrinol Metab. 2005; 90(3): 1888-1896.
51. Neuringer I, Charlermskulrat W, Aris R. Obliterative Bronchiolitis: Basic mechanisms of chronic lung rejection. J Heart Lung Transplant. 2005; 24: 3-19.
52. Van Deventer H, Oconnor W, Brickey W, Aris R, Ting J, Serody J. Chemokine Receptor 5 (CCR5) Promotes Pulmonary Metastasis. Cancer Res. 2005; 65(8): 3374-3379. doi: 10.1158/0008-5472.CAN-04-2616
53. Neuringer I, Chalermskulrat W, Aris R. Special problems in long-term survivors of lung transplantation. Pulmonary and Critical Care Update (PCCU). 19(11). http://www.chestnet.org/education/online/. doi:
54. Neuringer I, Sloan J, Chalermskulrat W, et al. Calcineurin Inhibitor Effects on Growth and Phenotype of Human Airway Epithelial Cells In Vitro. Am J Transplant. 2005; 5(11): 2660-2670. doi: 10.1111/j.1600-6143.2005.01071.x
55. Charlermskulrat W, BrickeyW, Neuringer I, et al. Combined donor specific transfusion and anti-CD154 therapy achieves airway allograft tolerance. Thorax. 2006; 61(1): 61-67. doi: 10.1136/thx.2005.047316
56. Snell G, Valentine V, Vitulo P, et al. Everolimus vs azathioprine as adjunctive immunosupressive therapy to inhibit the decline of pulmonary function in stable lung or heart/lung transplant recipients: 12 and 24-Month Results of an International, Randomized, Double-Blind Study. Am J Transplant . 2006; 6: 169-177. doi: 10.1111/j.1600-6143.2005.01134.x
57. Dua S, Chalermskultat W, Miller M, Landers M, Aris R. Bilateral Pseudomonas endopthalmitis after lung transplantation. Am J Transplant. 2006; 6: 219-224. doi: 10.1111/j.1600-6143.2005.01133.x
58. Kovarik J, Snell G, Valentine V, et al. Everolimus in pulmonary transplantation: pharmacokinetics and exposure-response relationships. J Heart Lung Transplant. 2006; 25(4): 440-446.
59. Chalermskulrat W, Sood N, Neuringer I, et al. Non tuberculous Mycobacteria in End-Stage Cystic Fibrosis: Implications for Lung Transplantation. Thorax. 2006; 61(6): 507-513. doi: 10.1136/thx.2005.049247
60. Dellon E, Morgan D, Mohanty S, Davis K, Aris R. High Incidence of Bezoars in Cystic Fibrosis Patients after Lung Transplantation. Transplantation. 2007; 81(8): 1141-1146. doi: 10.1097/01.tp.0000205813.54136.85
61. Kennedy M, Coakley R, Donaldson S, et al. Burkholderia Gladioli: Five-year Experience in a CF Referral and Lung Transplantation Center. J Cystic Fibrosis. 2007; 6(4): 267-273. doi: 10.1016/j.jcf.2006.10.007
62. Clines G, Kingsley L, McKibbin C, Gabriel S, Aris R. CF bone disease: Is mutant CFTR really the culprit. Ped Pulmonology. 2007; 188-189.
63. Neuringer I, Medaiyese A, McNeillie P, Budd S, Aris R. New Insights into Lung Allograft Rejection. CurrResp Med Rev. 2008; 4: 40-51.
64. Wheless S, Gulley M, Raab N, et al. Post Transplantation Lymphoproliferative Disorder: Epstein Barr Viral Loads, HLA A3, and Survival. Am J RespirCrit Care Med. 2008; 178(10): 1060-1065.
65. Aris R. Update on Bone Mineralization in CF. Pediatric Pumonol. 2008; (Supp 31): 173-175.
66. Ford HJ, Andreoni K, Aris RM. Screening for Porto pulmonary Hypertension with Transthoracic Echocardiography: Implications for Early Mortality Associated with Liver Transplantation. Am J Respir Crit Care Med. 2009; 180(4): 378.
67. Sermet I, Castanet M, Retsch G, Aris R. Update on Bone Disease in CF with a Focus on Children. Paediatr Respir Rev. 2009; 10(3): 134-142. doi: 10.1016/j.prrv.2009.05.001
68. Neuringer I, Noone P, Cicale R, Davis K, Aris R. Managing complications following lung transplantation. Expert Reviews in Respiratory Medicine. 2009; 3(4): 403-423. doi: 10.1586/ers.09.27
69. Lommatszch S, Aris RM. The Genetics of Cystic Fibrosis. Semin Respir Crit Care Med. 2009 ; 30(5): 531-538.
70. Sparks A, McGee S, Boone C, Neuringer I, Jones S, Aris R. Old Bones in Young Bodies: The Tale of Cystic Fibrosis. Curr Opin Endocrinol Diabetes Obes. 2009; 16(6): 407-414. doi: 10.1097/MED.0b013e3283329b16
71. Hall W, Sparks A, Aris R. Vitamin D Deficiency in Cystic Fibrosis. Int J Endocrinol. 2010; 2010: 218691. doi: http://dx.doi.org/10.1155/2010/218691
72. Palmer S, Limaye A, Banks M, et al. Extended Valganciclovir Prophylaxis To Prevent Cytomegalovirus After Lung Transplantation: A Randomized Controlled Trial. Ann Int Med. 2010; 152(12): 761-769. doi: 10.7326/0003-4819-152-12-201006150-00003
73. Neuringer I, Aris RIs it time to prospectively match human leukocyte antigen proteins for lung transplantation?. Transplantation. 2010; 90(8): 823-824. doi: 10.1097/TP.0b013e3181f2c99e
74. Sermet I, Bianchi M, Garabedian M, et al. European cystic fibrosis bone mineralisation guidelines. J Cyst Fibros. 2011; 10(Supp 2): S16-S23. doi: 10.1016/S1569-1993(11)60004-0
75. Aris R. Does transplantation alter vitamin D management. Ped Pulmonol. 2011; suppl (34): 111-113.
76. Goralski J, Aris R. Achieving Optimal Bone Health in Cystic Fibrosis: Ready for Prime Time? Therapy. 2011; 8: 587-590.
77. Judson M, Highland K, Kwon S, et al. Ambrisentan for sarcoidosis associated pulmonary hypertension. Sarcoidosis Vasc Diffuse Lung Dis. 2011; 28(2): 139-145.
78. Hall W, Aris R. Images in Pulmonary Medicine: Epidural Pneumatosis and Diffuse Soft Tissue Free Air As a Complication of Diabetic Ketoacidosis. Am J Resp Crit Care Med. 2012; 185(4): e5. doi: 10.1164/rccm.201105-0916IM
79. Tangpricha V, Kelly A, Stephenson A, et al. The Cystic Fibrosis Foundation Vitamin D Evidence-Based Review Committee An Update on the Screening, Diagnosis, Management, and Treatment of Vitamin D Deficiency in Individuals with Cystic Fibrosis: Evidence-Based Recommendations from the Cystic Fibrosis Foundation. J Clin Endocrinol Metab. 2012.
80. Budd S, Aris RM, Funkhouser W, Cicale B, Davis WK, Neuringer IP. Increased Mannose Binding Lectin Levels Are Associated with Bronchiolitis Obliterans after Lung Transplantation. Transplantation Resp Res. 2012; 413(1): 56. doi: 10.1186/1465-9921-13-56
81. Fares W, Blanchard S, Stouffer G, et al. Thermodilution and Fick Cardiac Outputs Differ: Impact on Pulmonary Hypertension Evaluation. Can Respir J. 2012; 19(4): 261-266. doi:
82. Fares W, Ford H, Ghio A, Aris R. Safety and feasibility of obtaining wedged pulmonary artery samples and differential distribution of bio markers in pulmonary hypertension. Pulm Circ. 2012; 2: 477-482. doi: 10.4103/2045-8932.105036
83. Lobo L, Aris R, Schmitz J, Neuringer I. Donor Specific Antibodies are associated with Antibody Mediated Rejection, Acute Cellular Rejection, BOS and Cystic Fibrosis after Lung Transplantation. J Heart Lung Transplant. 2013; 32(1): 70-77. doi: 10.1016/j.healun.2012.10.007
84. Lobo L, Aris R, Norfolk SG, et al. Rituximab associated Progressive Multifocal Leukoencephalopathy After Lung Transplantation. Transplantation J Heart Lung Transplant. 2013 ; 32(7): 752-753. doi: 10.1016/j.healun.2013.04.007
85. Lobo LJ, Aris R. Does Ischemia Reperfusion Injury After Transplantation Damage Native. Organs Transplantation.
86. Meyer K, Raghu G, Verleden GM, et al. An international ISHLT/ATS/ERS clinical practice guideline: diagnosis and management of bronchiolitis obliterans syndrome. Eur Resp Journal. doi: 10.1183/09031936.00107514
87. McNeillie P, Hammett C, Olegessi O, et al. Inhaled Cyclosporine Alters Airway Epithelial Signaling: Implications for Lung Diseases. Beyond Graft Rejection . Lung.

Seth Walker, MD, FCCP, FAAP

Assistant Professor of Medicine
Division of Pulmonary, Allergy, and Critical Care Medicine
Emory University
1365 Clifton Rd NE, Bldg A #4325
Atlanta, GA 30322, USA

BiographyResearch InterestScientific ActivitiesPublications

Dr. Walker is currently the Director of the Emory Adult Cystic Fibrosis Program in Atlanta, GA. He completed an internal medicine and pediatrics residency at Virginia Commonwealth University then did his adult pulmonary and critical care fellowship at the University of Rochester. In addition to clinical duties, he is co-director of the Therapeutic Development Center at Emory University and is involved with several clinical trials in cystic fibrosis.

His research interests include: Pulmonary Disease , Internal Medicine , Pediatrics, critical care medicine and cystic fibrosis.

Committee Memberships:

a) National and International:

• American Thoracic Society, Wheezing Infant Clinical Working Group, 2010-2014
• Cystic Fibrosis Foundation, Therapeutic Development Network Protocol Review Committee, 2014- Present


b) Institutional:

• Internal Medicine/Pediatrics Residency Education Committee, Charleston Area Medical Center/West Virginia University – Charleston Division, 2008-2011
• Internal Medicine/Pediatrics Resident Evaluation and Review Committee, Charleston Area Medical Center/West Virginia University – Charleston Division, 2008- 2011
• Nutritional Support Committee, Medical Director, Charleston Area Medical Center, 2008- 2011
• Central Line- Associated Blood Stream Infection Committee, Charleston Area Medical Center, 2009-2011
• Ethics Committee, Charleston Area Medical Center, 2009-2011
• Patient Satisfaction Improvement Group, The Emory Clinic Pulmonary Division, 2012-2011


Honors and Awards

• Cystic Fibrosis Foundation Outstanding Partnership Award, 2013


Society Memberships:

• American College of Chest Physicians, Fellow, 2005-Present
• American Thoracic Society, 2006-Present
• American Academy of Pediatrics, Fellow, 2013-Present

Journal Publications

1. Scarlett EE, Walker S, Rovitelli A, Ren CL. Tidal breathing responses to albuterol and normal saline in infants with viral bronchioloitis. Pediatric Allergy, Immunology, and Pulmonology. 2012; 25(4): 220-225. doi: 10.1089/ped.2012.0141


Other Publications:


1. Walker S. When will the Tobacco Control Act be considered a failure? . Austin J Pulm Respir Med .2014; 1(2): 1-2.

Kaori Ihida-Stansbury, PhD

Research Assistant Professor
Department of Pathology & Laboratory Medicine
Perleman School of Medicine
University of Pennsylvania
Philadelphia, PA, USA

BiographyResearch InterestScientific ActivitiesPublications

Dr. Ihida-Stansbury received her PhD in Biomedical Science in Japan. Her first post-doctoral training was at the Novel laureate Dr. George Palade at the University of California at San Diego followed by the training at the University of Denver Health Sciences Center. In 2005, she joined to the department of Pathology and Laboratory Medicine at the University of Pennsylvania as a Research Associate and promoted to an Assistant Professor in 2008.

Her research interests include: lung vascular development in embryonic development and disease, extracellular matrix to cell signaling, tissue regeneration, pulmonary arterial hypertension, TGF-beta signaling, 2D and 3D cell culture systems, ultrastructural analysis.

Awards and Fellowships


• (1988) Young Scientist Award:Kodama Foundation for Research of Medical Science
• (1990) Grant-in-Aid, Ministry of Education, Science and Culture, Japan.For young scientists
• (1990) Young Scientist Award: Kodama Foundation for Research of Medical Science
• (1991) Grant-in-Aid, Ministry of Education, Science and Culture, Japan For young scientists
• (1992) Grant-in-Aid, Ministry of Education, Science and Culture, Japan For young scientists
• (1992) Young Scientist Award: Kodama Foundation for Research of Medical Science
• (1993) Grant-in-Aid, Ministry of Education, Science and Culture, Japan For young scientists
• (2003) NIH postdoctoral trainee fellowship Cardiovascular Pulmonary Research Laboratory Univ. Colorado Health Sciences Center Kaori Ihida-Stansbury, PhD 3
• (2005) Beginning Grant-in-Aid American Heart Association Pennsylvania/Delaware affiliate
• (2006) Young Investigator Award: American Heart Association, Pennsylvania Affiliate


Memberships


• American Society for Cell Biology
• North American Vascular Biology Organization
• Pulmonary Hypertension Association
• American Thoracic Society
• American Physiological Society
• University of Pennsylvania Regenerative Medicine Institute
• University of Pennsylvania Cardiovascular Institute
• University of Pennsylvania Institute for Translational Medicine and Therapies

Presentations by invitation, including major symposia


1. Stansbury KI.The role of homeobox genes in pulmonary vascular development. Cardiovascular Pulmonary Laboratory (CVP) Conference. 2003.
2. Stansbury KI. The paired-related homeobox gene Prx1 is required for lung vascular development: role in vasculogenesis and angiogenesis. NAVBO Developmental Vascular Biology Workshop Pacific Grove. 2004.
3. Stansbury KI. The paired-related homeobox gene, Prx1, in pulmonary vascular development and disease. Cardiovascular Pulmonary Laboratory Conference. 2004.
4. Thomas L. Regulation and functions of the paired-related homeobox gene Prx1, in pulmonary vascular development and disease. The 47th Annual Meeting Petty Aspen Lung Conference. 2004.
5. Stansbury KI. BMP type II receptor mutations linked to familial forms of primary pulmonary hypertension regulate tenascin-C via induction of Prx1. Cardiovascular Pulmonary Laboratory Conference. 2004.
6. Stansbury KI. BMP type II receptor mutations linked to familial forms of primary pulmonary hypertension regulate tenascin-C via induction of Prx1. The 44th Annual Meeting American Society for Cell Biology. 2004.
7. Stansbury KI. Control of vascular smooth muscle cell matrix production by BMP type II receptors. Pennsylvania Muscle Institute 14th Annual Retreat & Symposium. 2005.
8. Stansbury KI. Mutated bone morphogenetic protein type II receptors induce expression of Tenascin-C by down-regulation of R-Smad signaling via ERK1/2MAPK. 6th Pan Pacific Connective Tissue Societies Symposium. 2005.
9. Stansbury KI. Control of lung vascular development by Prx1 in health and disease. Graduate School Seminar Series, School of Medicine, University of Tokyo. 2007.
10. Stansbury KI. Control of lung vascular development by Prx1. Research in Progress Seminar Series, Lung Biology Center, University of South Alabama. 2009.
11. Stansbury KI. Importance of tissue handling and shipping for receipt of fresh tissue. PHBI coordinator meeting. University of Alabama. 2010.
12. Stansbury KI.Cell-free matrices to study lung vascular development and pulmonary hypertension. PHBI annual face-to-face meeting. 2011.
13. Stansbury KI. Control of lung vascular development by Prx1. University of Pennsylvania Pulmonary A&I Research Conference, University of Pennsylvania. 2011.
14. Stansbury KI. Microenvironment and Cell behavior: How micro-level environment affect cell behavior in health and disease. Invited lecture at the Dept. Architecture Cornell University. 2012.
15. Stansbury KI. ECM-dependent lung vascular morphogenesis in embryo and PAH. Lung biology institute special seminar. University of South Alabama. 2013.

Afroditi K Boutou, MD, MSc, PhD

Respiratory Medicine
Post-doctoral Research Fellow
Respiratory Failure Unit, Papanikolaou General Hospital
Aristotle University of Thessaloniki
Sarafi 9-13, 55132, Kalamaria, Thessaloniki, Greece

BiographyResearch InterestScientific ActivitiesPublications

Dr. Afroditi K Boutou is a MD, MSc, PhD of Respiratory Medicine Specialist and Research Fellow in Respiratory Failure Unit, Aristotle University of Thessaloniki, Greece.


Employment and Training


• (2004-2006) General Medicine (SHO level), Department of Medicine, General Hospital of Goumenissa, Kilkis, Greece
• (2006-2008) Clinical Research Fellow, Respiratory Failure Unit, Papanikolaou General Hospital, Aristotle University of Thessaloniki, Greece
• (2008-2008) Respiratory Medicine, Department of Respiratory Medicine, Theageneio Cancer Hospital of Thessaloniki, Greece (Registrar Equivalent)
• (2008-2013) Respiratory Medicine, Respiratory Failure Unit, Papanikolaou General Hospital, Aristotle University of Thessaloniki, Greece (Registrar Equivalent-completion of medical specialty in Respiratory Medicine). Three months of this specialty training • (2011-2011) were completed in NIHR Respiratory Biomedical Research Unit, Royal Brompton Hospital and Imperial College NHS Foundation Trust, London, United Kingdom.
• (2013-2013) NIHR Respiratory Biomedical Research Unit, Royal Brompton Hospital and Imperial College NHS Foundation Trust, London, United Kingdom (Honorary Research Clinical Fellow, under a European Respiratory Society Fellowship (STFR 2012-258))
• (2013-Present) Respiratory Medicine, Post-doctoral Research Fellow, Respiratory Failure Unit, Papanikolaou General Hospital, Aristotle University of Thessaloniki, Greece.


She has authored numerous research papers in international medical journals.

Her research interests include: Chronic Obstructive Pulmonary Disease, Cardiopulmonary Exercise Testing, Exercise capacity in disorders affecting the respiratory system, Pulmonary circulation.

HONORS AND AWARDS


• (2002-2003) Performance Prize from the Greek Foundation of State Scholarships for the 5th academic year in Medical School
• (2008) CHOISES: Champix Observational Investigation in the Cessation of Smoking. Protocol ID: A3051085, Pfizer Inc.
• (2008-2010) Greek Smoking Cessation Network, Protocol ID:83536 Aristotle University of Thessaloniki
• (2009) Global Health Partnership 2008: The Greek proposal for Smoking Cessation, Pfizer Foundation.
• (2013) Research Fellowship from the European Respiratory Society (STFR-2012-258) for the project: “Pulmonary vascular appearances and survival in COPD” which was carried out at the Respiratory Biomedical Research unit of Royal Brompton Hospital, London, UK

List of publications in International Medical Journals


1. Kotsaftis P, Girtovitis F, Boutou A, Ntaios G, Makris PE. Haemarthrosis after superwarwarin poisoning. European Journal of Haematology. 2007; 79(3): 255-257. doi: 10.1111/j.1600-0609.2007.00904.x
2. Stanopoulos I, Manolakoglou M, Pitsiou G, et al. Sildenafil may facilitate weaning in mechanically ventilated COPD patients: a report of three cases. Anaesthesia Intensive Care. 2007; 35(4): 611-613.
3. Boutou AK, Tsiata EA, Pataka A, Kontou PK, Pitsiou GG, Argyropoulou P. Smoking cessation in clinical practice: predictors of continuous abstinence in a sample of Greek smokers. Primary Care Respiratory Journal. 2008; 17(1): 32-38. doi: 10.3132/pcrj.2008.00009
4. Boutou AK, Trigonis I, Pigadas A, Argyropoulou P, Stanopoulos I. Exogenous lipoid pneumonia complicated with mycobacterium infection in a subject with Zenker diverticulum. Annals Academy of Medicine Singapore. 2009; 38(2): 177-178.
5. Boutou AK, Stanopoulos I, Pitsiou G, Argyropoulou P. Pulmonary hypertension therapy and COPD: still many questions to be answered. European Respiratory Journal. 2009; 33(2): 449-445. doi: 10.1183/09031936.00146108
6. Pitsiou GG, Chavouzis N, Nakou C, Boutou AK, Argyropoulou P, Stanopoulos I. Successful upfront combination therapy in a patient with idiopathic pulmonary hypertension and patent foramen ovale: an alternative to epoprostenol therapy. The Journal of Heart and Lung Transplantation. 2009; 28(6): 651-653. doi: 10.1016/j.healun.2009.03.009
7. Pitsiou GG, Spyratos D, Kioumis I, Boutou AK, Nakou C, Stanopoulos I. Sarcoidosis-associated pulmonary hypertension: a role for endothelin receptor antagonists. Therapeutic Advances in Respiratory Disease. 2009; 3(3): 99-101. doi: 10.1177/1753465809341650
8. Konstantinidis ST, Konstantinidis E, Nikolaidou MM, et al. The use of open source and Web2.0 in developing an integrated EHR and e-learning system for the Greek Smoking Cessation Network. Stud Health Technol Inform. 2009; 150: 354-358. doi: 10.3233/978-1-60750-044-5-354
9. Boutou AK, Abatzidou F, Tryfon S, et al. Diagnostic accuracy of the rapid shallow breathing index to predict a successful spontaneous breathing trial outcome in mechanically ventilated patients with chronic obstructive pulmonary disease. Heart & Lung. 2011; 40(2): 105-110. doi: 10.1016/j.hrtlng.2010.02.002.
10. Pitsiou GG, Boutou AK, Nakou C, et al. Resolution of nocturnal periodic breathing in pulmonary hypertension after optimal treatment. Therapeutic Advances in Respiratory Disease. 2010; 4(4): 249-251. doi: 10.1177/1753465810371336
11. Boutou AK, Pitsiou GG, Trigonis I, et al. Exercise capacity in idiopathic pulmonary fibrosis: the effect of pulmonary hypertension. Respirology. 2011; 16(3): 451-458. doi: 10.1111/j.1440-1843.2010.01909.x
12. Boutou AK, Stanopoulos I, Pitsiou GG, et al. Anemia of chronic disease in COPD: a case-control study on cardiopulmonary exercise responses. Respiration. 2011; 82(3): 237-245. doi: 10.1159/000326899
13. Kontakiotis T, Boutou AK, Ioannidis D, Papakosta D, Argyropoulou P. Lung function testing values in a Greek population: Is there an appropriate reference equation. Respirology. 2011; 16(6): 947-952.
14. Boutou AK, Pitsiou GG, Stanopoulos I, Kontakiotis T, Kyriazis G, Argyropoulou P. Levels of inflammatory mediators in chronic obstructive pulmonary disease patients with anemia of chronic disease: a case-control study. QJM . 2012; 105(7): 657-663. doi: 10.1093/qjmed/hcs024
15. Pitsiou G, Bagalas V, Boutou A, Stanopoulos I, Argyropoulou PP. Should we routinely screen patients with idiopathic pulmonary fibrosis for nocturnal hypoxemia. Sleep Breath. 2013; 17(2): 447-448. doi: 10.1007/s11325-012-0716-0
16. Boutou AK, Karrar S, Hopkinson NS, Polkey MI. Anemia and survival in chronic obstructive pulmonary disease: a dichotomous rather than a continuous predictor. Respiration. 2013; 85(2): 126-131. doi: 10.1159/000338792
17. Pitsiou G, Kachrimanidou M, Papa A, et al. Lemierres syndrome presenting to the ED: rapidly fatal sepsis caused by methicillin-susceptible Staphylococcus aureus Staphylococcus protein A type t044. American Journal of Emergency Medicine. 2013; 31(1): 268: e5-e7. doi: 10.1016/j.ajem.2012.04.028
18. Elia D, Kelly JL, Martolini D, et al. Respiratory muscle fatigue following exercise in patients with interstitial lung disease. Respiration. 2013; 85(3): 220-227. doi: 10.1159/000338787
19. Manika K, Pitsiou GG, Boutou AK, et al. The Impact of Pulmonary Arterial Pressure on Exercise capacity in mild-to-moderate cystic fibrosis: A case control study. Pulmonary Medicine. 2012; 2012: 252345. doi: http://dx.doi.org/10.1155/2012/252345
20. Sourla E, Paspala A, Boutou A, Kontou P, Stanopoulos I, Pitsiou G. A case of pulmonary veno-occlusive disease: diagnostic dilemmas and therapeutic challenges. Ther Adv Respir Dis. 2013; 7(2): 119-123. doi: 10.1177/1753465812468042
21. Boutou AK, Shrikrishna D, Tanner RJ, et al. Lung function indices for predicting mortality in COPD. Eur Respir J. 2013; 42(3): 616-625. doi: 10.1183/09031936.00146012
22. Pitsiou G, Paspala A, Bagalas V, Boutou AK, Stanopoulos I. Inhaled iloprost plus levosimendan to decompensate right heart failure due to chronic thromboembolic pulmonary hypertension. Anaesth Intensive Care. 2013; 41(4): 554-556.
23. Paspala A, Sourla E, Boutou A, et al. Repeated episodes of respiratory failure due to bilateral vocal cord paralysis. J Emerg Med. 2013; 45(5): e145-e148. doi: 10.1016/j.jemermed.2013.05.053
24. Boutou AK, Hopkinson NS, Polkey MI. Predictors of exacerbations in COPD patients: the role of anemia. Int J Clin Pract. 2014; 68(1): 139-140. doi: 10.1111/ijcp.12270
25. Zoumot Z, Boutou AK, Gill SS, et al. Mycobacterium avium complex infection in non-cystic fibrosis bronchiectasis. Respirology. 2014; 19(5): 714-722. doi: 10.1111/resp.12287
26. Boutou AK, Pitsiou GG, Argyropoulou P. Non-invasive markers of pulmonary hypertension in interstitial lung disease: is cardiopulmonary exercise testing the Holy Grail? Respirology. 2014; 19(5): 621-622. doi: 10.1111/resp.12321
27. Boutou AK, Raste Y, Reid J, Alshafi K, Polkey MI, Hopkinson NS. Does a single Pseudomonas aeruginosa isolation predict COPD mortality? Eur Respir J. 2014; 44(3): 794-797. doi: 10.1183/09031936.00023414
28. Bagalas V, Paspala A, Sourla E, et al. Chronic Thromboembolic Pulmonary Hypertension: Do not Miss the Chance for an Early Diagnosis. Am J Case Rep. 2014; 15: 378-381. doi: 10.12659/AJCR.891014
29. Boutou AK, Hopkinson NS, Polkey MI. Anemia in Chronic Obstructive Pulmonary Disease: an insight into its prevalence and pathophysiology. Clin Sci . 2014. doi: 10.1042/CS20140344
30. Lord VM, Hogg L, Nolan J, et al. An evaluation of factors associated with completion and benefit from pulmonary rehabilitation in COPD. BMJ Open Resp Res. 2014. doi: 10.1136/bmjresp-2014-000051
31. Boutou AK, Nair A, Douraghi-Zadeh D, et al. A combined pulmonary function and emphysema score prognostic index for staging in Chronic Obstructive Pulmonary Disease. PLOS One. doi: 10.1371/journal.pone.0111109.

Denise Serebrisky, MD

Director
Department of Pediatric Pulmonary
Jacobi Medical Center
1400 Pelham Parkway South, USA

BiographyResearch InterestScientific ActivitiesPublications

Dr. Denise Serebrisky received her medical degree from University of Buenos Aires, Argentina and completed her pediatric residency at Montefiore Medical Center in Bronx, NY. She completed her Pediatric Pulmonary Fellowship at Mount Sinai Hospital in New York, NY. Dr. Serebrisky is board-certified in Pediatric Pulmonology.
Dr. Serebrisky is currently an Associate Professor of Pediatrics at Albert Einstein College of Medicine and is the Director of the Pediatric Pulmonary Division at Jacobi Medical Center.
As the Director of Pulmonary Medicine in the Department of Pediatrics, Dr Serebrisky is committed to investigate new pathways to improve patient outcomes among inner-city minority children with asthma. She has been the site PI for several studies focusing on childrens asthma symptom perception. She was the site PI for the Genes-environment, Admixure and Latino (GALA) study, which focuses on asthma disparities between Mexican and Puerto Rican children, as well as a Co-Investigator on an R01 study looking at the effectiveness of environmental intervention and standard care in ability to reduce pharmacologic therapy for asthma.

Her research interests include: Childrens asthma symptom perception.

HONORS AND AWARDS


• (1990) Cum Laude, University of Buenos Aires School of Medicine
• (1998) Alfred Soffer Research Award finalist. CHEST 1998, the XIX World Congress on Diseases of the Chest and the 64th Annual International Scientific Assembly of the American College of Chest Physicians.


OTHER PROFESSIONAL ACTIVITIES


• (1997) Member, Pediatrics Assembly, American Thoracic Society
• Member of New York City Asthma Partnership Data and Surveillance Committee
• Member, New York City Health and Hospital Corporation, Executive Leadership Asthma Task Force
• (2004) Member, South Bronx Asthma Partnership
• (2005) Senior Asthma Project Physician New York City Health and Hospital Corporation Pediatric Chronic Disease Collaborative
• (2011) Reviewer, Journal of Pediatrics

Original Communications in Reviewed Journals


1. Serebrisky D, Teper AA, Huang CK, et al. CpG oligodeoxynucleotides can reverse Th2-associated allergic airway responses and alter the B7.1/B7.2 expression in a murine model of asthma. J Immunol. 2000; 165(10): 5906-5912. doi: 10.4049/jimmunol.165.10.5906
2. Li XM, Serebrisky D, Lee SY, et al. A murine model of peanut anaphylaxis: T-and B-cell responses to a major peanut allergen mimic human responses. J Allergy Clin Immunol. 2000; 106(1(1)): 150-158. doi: http://dx.doi.org/10.1067/mai.2000.107395
3. Serebrisky D, Cordero R, Kattan M, Lamm C. Assessment of inspiratory flow limitation in children with sleep-disordered breathing by a nasal cannula pressure transducer system. Pediatric Pulmonol. 2002; 33: 38-387. doi: 10.1002/ppul.10096
4. Wisnivesky J, Serebrisky D, Moore C, Iannuzzi M, Sacks H, McGinn T. Validity of clinical prediction rules for isolating in patients with suspected tuberculosis: a meta-analysis. J Gen Intern Med. 2005; 10: 947-952.
5. Choudhry S, Seibold MA, Borrell LN, et al. Dissecting complex diseases in complex populations: asthma in latino Americans. Proc Am Thorac Soc. 2007; 4(3): 226-233.
6. Scarfi CA, Cunningham SJ, Wiznia A, Serebrisky D, Crain EF. Association between skin testing in the pediatric emergency department and adherence to follow-up in children with asthma. Ann Allergy Asthma Immunol. 2009; 102(1): 35-40. doi: 10.1016/S1081-1206(10)60105-6
7. Jacobson JS, Lieblein A, Fierman AH, et al. Randomized Trial of an Electronic Asthma Monitoring System among NYC Children. Am J Manag Care. 2009; 15(11): 809-814.
8. Sidora AK, Feldman J, Serebrisky D, Spray A. Validation of the Asthma Illness Representation Scale (AIRS). J Asthma. 2010; 47(1): 33-40. doi: 10.3109/02770901003702832
9. Sidora AK, Feldman J, Serebrisky D, Spray A. Validation of the Asthma Illness Representation Scale-Spanish (AIRS-S). J Asthma. 2010; 47(4): 417-421. doi: 10.3109/02770901003702832
10. Feldman JM, Mayefsky L, Beckmann L, Lehrer PM, Serebrisky D, Shim C. Ethnic differences in asthma-panic disorder comorbidity. J Allergy Clin Immunol. 2010; 125(3): 760-762. doi: 10.1016/j.jaci.2009.11.002
11. Sidore AK, Feldman JM, Serebrisky D, Spray A. A multi-factorial model for examining racial and ethnic disparities in acute asthma visits by children. Ann Behav Med. 2012; 43(1): 15-28. doi: 10.1007/s12160-011-9328-3
12. Oh SS, Tcheurekdjian H, Roth LA, et al. Effect of secondhand smoke on asthma control among Black and Latino children. J Allergy Clin Immunol. 2012; 129(6): 1478-1483. doi: 10.1016/j.jaci.2012.03.017
13. Steinberg DM, Sidora AK, Serebrisky D, Feldman JM. The relationship between caregivers’ post-traumatic stress disorder and their asthma health beliefs in an ethnic minority inner-city sample. J Asthma. 2012. doi: 10.3109/02770903.2012.696169
14. Myers RA, Himes BE, Gignoux CR, et al. Further replication studies of the EVE Consortium meta-analysis identifies 2 asthma risk loci in European Americans. J Allergy Clin Immunol. 2012; 130(6): 1294-1301. doi: 10.1016/j.jaci.2012.07.054
15. Feldman JM, Kutner H, Matte L, et al. Prediction of peak flow values followed by feedback improves perception of lung function and adherence to inhaled corticosteroids in children with asthma. Thorax. 2012; 67(12): 1040-1045. doi: 10.1136/thoraxjnl-2012-201789
16. Borrell LN, Nguyen EA, Roth LA, et al. Childhood Obesity and Asthma Control in a Diverse Sample: Examining age and Racial/Ethnic Differences. Am J Respir Crit Care Med. 2013; 187(7): 697-702.
17. Kumar R, Nguyen EA, Roth LA, et al. Factors associated with degree of atopy in Latino children in a nationwide pediatric sample: The Genes-environments and Admixture in Latino Asthmatics (GALA II) study. J Allergy Clin Immunol. 2013.doi: 10.1016/j.jaci.2013.02.046
18. Nishimura KK, Galanter JM, Roth LA, et al. Early Life Air Pollution and Asthma Risk in Minority Children: The GALA II & SAGE II Studies. Am J Respir Crit Care Med. 2013; 188(3): 309-318. doi: 10.1164/rccm.201302-0264OC
19. Feldman JM, Steinberg D, Kutner H, et al. Perception of Pulmonary Function and Asthma Control: The Differential Role of Child Versus Caregiver Anxiety and Depression. J Pediatr Psychol. 2013; 38(10): 1091-100. doi: 10.1093/jpepsy/jst052
20. Drake KA, Torgerson DG, Gignoux CR, et al. A genome-wide association study of bronchodilator response in Latinos implicates rare variants. J Allergy Clin Immunol. 2013. doi: 10.1016/j.jaci.2013.06.043
21. Thakur N, Oh SS, Nguyen EA, et al. Socioeconomic Status and Childhood Asthma in Urban Minority Youths: The GALA II & SAGE II Studies. Am J Respir Crit Care Med. 2013; 188(10): 1202-1209. doi: 10.1164/rccm.201306-1016OC
22. Galanter JM, Gignoux CR, Torgerson DG, et al. Genome-wide association study and admixture mapping identify different asthma-associated loci in Latinos: The Genes-environments & Admixture in Latino Americans study. J Allergy Clin Immunol. 2014. doi: 10.1016/j.jaci.2013.08.055

Fulvio Lonardo, MD

Professor
Department of Pathology
Harper University Hospital
3990 John R
Detroit, MI 48201, USA

BiographyResearch InterestScientific ActivitiesPublications
EDUCATION


• (1978-1985) MD (summa cum laude), 2nd Medical School, Naples, Italy


POSTGRADUATE TRAINING


• (1986-1987) Guest Researcher, Laboratory of Cellular and Molecular Biology NCI, Bethesda
• (1987-1990) Fogarty International fellow, Laboratory of Cellular and Molecular Biology NCI, Bethesda
• (1990-1993) Residency in Anatomic Pathology, University of Rochester Medical Center, Rochester, NY
• (1993-1994) Wilmot Cancer Research fellow, University of Rochester Medical Center, Rochester, NY
• (1994-1995) Oncologic Anatomic Pathology Fellow, Memorial Sloan Kettering Cancer Center, NYC
• (1995-1999) Experimental Pathology Fellow, Memorial Sloan Kettering Cancer Center, New York, NY


FACULTY APPOINTMENTS


• (1999-2005) Assistant Professor, Harper Hospital Wayne State University School of Medicine, Detroit, MI
• (2006-2011) Associate Professor, Harper Hospital Wayne State University School of Medicine, Detroit, MI
• (2011-Present) Professor, Harper Hospital Wayne State University School of Medicine, Detroit, MI

His research interests include: Molecular pathogenesis of lung cancer, Relations between molecular and morphological features of lung cancer, Epidemiological aspects of lung cancer.

HONORS AND AWARDS


• (1987) Fogarty International Fellowship, National Institutes of Health
• (1993) Wilmot Cancer Research Fellowship, URMC
• (2010) Residents teacher award


MEMBERSHIPS


• (1999- Present) International Academy of Pathology
• (2002-Present) American Association for Cancer Research

Peer reviewed publications (in chronological order)


1. Segatto O, Lonardo F, Pierce JH, Bottaro DP, Di Fiore PP. The role of autophosphorylation in modulation of erbB-2 transforming function. New Biol. 1990; 2(2): 187-195.
2. Di Fiore PP, Segatto O, Lonardo F, Fazioli F, Pierce JH, Aaronson SA. The carboxy-terminal domains of erbB-2 and epidermal growth factor receptor exert different regulatory effects on intrinsic receptor tyrosine kinase function and transforming activity. Mol Cell Biol. 1990; 10(6): 2749-2756. doi: 10.1128/MCB.10.6.2749
3. Di Fiore PP, Segatto O, Lonardo F, Fazioli F, Pierce JH, Aaronson SA. The normal erbB-2 product is an atypical receptor-like tyrosine kinase with constitutive activity in the absence of ligand. New Biol. 1990; 2(11): 992-1003.
4. Segatto O, Lonardo F, Wexler D, et al. The juxta membrane regions of the epidermal growth factor receptor and gp185erbB-2 determine the specificity of signal transduction. Mol Cell Biol. 1991; 11(6): 3191-3202. doi: 10.1128/MCB.11.6.3191
5. Pierce JH, Arnstein P, DiMarco E, et al. Oncogenic potential of erbB-2 in human mammary epithelial cells. Oncogene. 1991; 6(7): 1189-1194.
6. Fligman I, Lonardo F, Jhanwar SC, Gerald WL, Woodruff J, Ladanyi M. Molecular diagnosis of synovial sarcoma and characterization of a variant SYT-SSX2 fusion transcript. Am J Pathol. 1995; 147(6): 1592-1599.
7. Langenfeld J, Lonardo F, Kiyokawa H, et al. Inhibited transformation of immortalized human bronchial epithelial cells by retinoic acid is linked to cyclin E down-regulation. Oncogene. 1996; 13(9): 1983-1990.
8. Lonardo F, Ueda T, Huvos AG, Healey J, Ladanyi M. p53 and MDM2 alterations in osteosarcomas: correlation with clinicopathologic features and proliferative rate. Cancer. 1997; 79(8): 1541-1547.
9. Albanell J, Lonardo F, Rusch V, et al. High telomerase activity in primary lung cancers: association with increased cell proliferation rates and advanced pathologic stage. J Natl Cancer Inst. 1997; 89(21): 1609-1615. doi: 10.1093/jnci/89.21.1609
10. Boyle JO, Langenfeld J, Lonardo F, et al. Cyclin D1 proteolysis: a retinoid chemoprevention signal in normal, immortalized, and transformed human bronchial epithelial cells. J Natl Cancer Inst. 1999; 91(4): 373-379. doi: 10.1093/jnci/91.4.373
11. Wei G, Lonardo F, Ueda T, et al. CDK4 gene amplification in osteosarcoma: reciprocal relationship with INK4A gene alterations and mapping of 12q13 amplicons. Int J Cancer. 1999; 80(2): 199-204.
12. Lonardo F, Rusch V, Langenfeld J, Dmitrovsky E, Klimstra DS. Overexpression of cyclins D1 and E is frequent in bronchial preneoplasia and precedes squamous cell carcinoma development. Cancer Res. 1999; 59(10): 2470-2476.
13. Califano J, Westra WH, Koch W, et al. Unknown primary head and neck squamous cell carcinoma: molecular identification of the site of origin. J Natl Cancer Inst. 1999; 91(7): 599-604. doi: 10.1093/jnci/91.7.599
14. Antonescu CR, Kawai A, Leung DH, et al. Strong association of SYT-SSX fusion type and morphologic epithelial differentiation in synovial sarcoma. Diagn Mol Pathol. 2000; 9(1): 1-8.
15. Boyle JO, Lonardo F, Chang JH, Klimstra D, Rusch V, Dmitrovsky E. Multiple high-grade bronchial dysplasia and squamous cell carcinoma: concordant and discordant mutations. Clin Cancer Res. 2001; 7(2): 259-266.
16. Yoo GH, Piechocki MP, Ensley JF, et al. Docetaxel induced gene expression patterns in head and neck squamous cell carcinoma using cDNA microarray and Power Blot. Clin Cancer Res. 2002; 8(12): 3910-3921.
17. Lonardo F, Dragnev KH, Freemantle SJ, et al. Evidence for the epidermal growth factor receptor as a target for lung cancer prevention. Clin Cancer Res. 2002; 8(1): 54-60.
18. Yoo GH, Piechocki MP, Lonardo F, et al. In vivo characteristics of HPV-immortalized and carcinogen transformed oral keratinocytes. Laryngoscope. 2002; 112(9): 1672-1679. doi: 10.1097/00005537-200209000-00027
19. Lechner JF, Wang Y, Siddiq F, et al. Human lung cancer cells and tissues partially recapitulate the homeobox gene expression profile of embryonic lung. Lung Cancer. 2002; 37(1): 41-47. doi: http://dx.doi.org/10.1016/S0169-5002(02)00036-3
20. Lucas DR, Pass HI, Madan SK, et al. Sarcomatoid mesothelioma and its histological mimics: a comparative immunohistochemical study. Histopathology. 2003; 42(3): 270-279. doi: 10.1046/j.1365-2559.2003.01583.x
21. Lonardo F, Pass HI, Lucas DR. Immunohistochemistry frequently detects c-Kit expression in pulmonary small cell carcinoma and may help select clinical subsets for a novel form of chemotherapy. Appl Immunohistochem Mol Morphol. 2003; 11(1): 51-55.
22. Shehadeh NJ, Vernick J, Lonardo F, et al. Sclerosing mucoepidermoid carcinoma with eosinophilia of the thyroid: a case report and review of the literature. Am J Otolaryngol. 2004; 25(1): 48-53. doi: 10.1016/S0196-0709(03)00096-6
23. Otero GJE, Youssef E, Enamorado II, et al. Prognostic significance of p53 and FHIT in advanced oropharyngeal carcinoma. Am J Otolaryngol. 2004; 25(4): 231-239. doi: http://dx.doi.org/10.1016/j.amjoto.2004.01.001
24. Yoo GH, Piechocki MP, Oliver J, et al. Enhancement of Ad-p53 therapy with docetaxel in head and neck cancer. Laryngoscope. 2004; 114(11): 1871-189. doi: 10.1097/01.mlg.0000147914.51239.ed
25. Siddiq F, Sarkar FH, Wali A, Pass HI, Lonardo F. Increased osteonectin expression is associated with malignant transformation and tumor associated fibrosis in the lung. Lung Cancer. 2004; 45(2): 197-205. doi: http://dx.doi.org/10.1016/j.lungcan.2004.01.020
26. Pass HI, Liu Z, Wali A, et al. Gene expression profiles predict survival and progression of pleural mesothelioma. Clin Cancer Res. 2004; 10(3): 849-859. doi: 10.1158/1078-0432.CCR-0607-3
27. Yoo GH, Lin HS, Iskander AJ, et al. Docetaxel associated pathways in cisplatin resistant head and neck squamous cell carcinoma: a pilot study. Laryngoscope. 2005; 115(11): 1938-1946. doi: 10.1097/01.mlg.0000177456.90870.94
28. Wali A, Morin PJ, Hough CD, et al. Identification of intelectin overexpression in malignant pleural mesothelioma by serial analysis of gene expression (SAGE). Lung Cancer. 2005; 48(1): 19-29. doi: http://dx.doi.org/10.1016/j.lungcan.2004.10.011
29. Pass HI, Lott D, Lonardo F, et al. Asbestos exposure, pleural mesothelioma, and serum osteopontin levels. N Engl J Med. 2005; 353(15): 1564-1573. doi: 10.1056/NEJMoa051185
30. Schwartz AG, Prysak GM, Murphy V, et al. Nuclear estrogen receptor beta in lung cancer: expression and survival differences by sex. Clin Cancer Res. 2005; 11(20): 7280-7287. doi: 10.1158/1078-0432.CCR-05-0498
31. Lonardo F, Li X, Siddiq F, et al. Maspin nuclear localization is linked to favorable morphological features in pulmonary adenocarcinoma. Lung Cancer. 2006; 51(1): 31-39. doi: http://dx.doi.org/10.1016/j.lungcan.2005.07.011
32. Piechocki MP, Yoo GH, Dibbley SK, Amjad EH, Lonardo F. Iressa induces cytostasis and augments Fas-mediated apoptosis in acinic cell adenocarcinoma overexpressing HER2/neu. Int J Cancer. 2006; 119(2): 441-454. doi: 10.1002/ijc.21837
Lin HS, Talwar HS, Tarca AL, Ionan A, et al. Autoantibody approach for serum-based detection of head and neck cancer. Cancer epidemiology, biomarkers & prevention. 2007; 16(11): 2396-2405. doi: 10.1158/1055-9965.EPI-07-0318
34. Molinolo AA, Hewitt SM, Amornphimoltham P, et al. Dissecting the Akt/mammalian target of rapamycin signaling network: emerging results from the head and neck cancer tissue array initiative. Clinical cancer research. 2007; 13(17): 4964-4973. doi: 10.1158/1078-0432.CCR-07-1041
35. Yoo GH, Tran VR, Lemonnier LA, et al. BMS-275183-induced gene expression patterns in head and neck carcinoma. American Journal of Otolaryngology. 2007; 28(5): 309-315. doi: http://dx.doi.org/10.1016/j.amjoto.2006.10.001
36. Francis WP, Rodriques DM, Perez NE, Lonardo F, Weaver D, Webber JD. Prophylactic laparoscopic-assisted total gastrectomy for hereditary diffuse gastric cancer. JSLS : Journal of the Society of Laparoendoscopic Surgeons / Society of Laparoendoscopic Surgeons. 2007; 11(1): 142-147.
37. Piechocki MP, Yoo GH, Dibbley SK, Lonardo F. Breast cancer expressing the activated HER2/neu is sensitive to gefitinib in vitro and in vivo and acquires resistance through a novel point mutation in the HER2/neu. Cancer Research. 2007; 67(14): 6825-6843. doi: 10.1158/0008-5472.CAN-07-0765
38. Frey AB, Wali A. Pass H, Lonardo F. Osteopontin is linked to p65 and MMP-9 expression in pulmonary adenocarcinoma but not in malignant pleural mesothelioma. Histopathology. 2007; 50(6): 720-726. doi: 10.1111/j.1365-2559.2007.02675.x
39. Schwartz AG, Wenzlaff AS, Prysak GM, et al. Reproductive factors, hormone use, estrogen receptor expression and risk in non small cell lung cancer in women. Journal of Clinical Oncology. 2007; 25(36): 5785-5792. doi: 10.1200/JCO.2007.13.3975
40. Van Dyke AL, Cote ML, Prysak G, et al. Schwartz A:COX 2/EGFR. Expression and Survival among Women with Adenocarcinoma of the Lung. Carcinogenesis. 2008; 29 (9): 1781-1787 doi: 10.1093/carcin/bgn107
41. Piechocki MP, Dibbey SK, Lonardo F, Yoo G. Gefitinib prevents cancer progression in mice expressing the activated rat Her2/neu. Int J Cancer. 2008; 122: 1722-1729. doi: 10.1002/ijc.23231
42. Yoo GH, Subramanian G, Piechocki MP, et al. Effect of Docetaxel on the surgical tumor microenvironment of head and neck cancer in murine model. Arch Otolaryngol Head Neck Surg. 2008; 134(7): 735-742. doi: 10.1001/archotol.134.7.735
43. Frey A, Soubani AO, Adam AK, Sheng S, Pass HI, Lonardo F. Nuclear, compared to combined nuclear and cytoplasmic expression of maspin is linked in lung adenocarcinoma to reduced VEGFA levels and in stage I, improved survival. Histopathology. 2009; 54: 590-597. doi: 10.1111/j.1365-2559.2009.03260.x
44. Yoo GH, Subraimanian G, Ezzat WH, et al. A phase 2 trial of surgery with perioperative INGN 201 (Ad5CMV-p53) gene therapy followed by chemoradiotherapy for advanced, resectable squamous cell carcinoma of the oral cavity, oropharynx, hypopharynx, and larynx: report of the Southwest Oncology Group. Archives of Otolaryngology-Head & Neck Surgery. 2009; 135(9): 869-874. doi: 10.1001/archoto.2009.122
45. Ivanova AV, Goparaju CM, Ivanov SV, et al. Protumorigenic role of HAPLN1 and its IgV domain in malignant pleural mesothelioma. Clinical Cancer Research. 2009; 15(8): 2602-2611. doi: 10.1158/1078-0432.CCR-08-2755
46. Yoo GH, Kafri Z, Ensley JF, et al. XRP 6258 Induced gene expression pattern in Head and Neck carcinoma. Laryngoscope. 2010; 120(6): 1114-1119. doi: 10.1002/lary.20559
47. Yoo GH, Tulunay OE, Trans VR, et al. Intratumoral delivery of docetaxel enhances antitumor activity of Ad-p53 in murine head and neck cancer xenograft model. Am J Otorlaryngol. 2010; 31(2): 78-83. doi: 10.1016/j.amjoto.2008.10.002.
48. Cote ML, Haddad R, Edwards E, et al. Frequency and type of EGFR mutations in African Americans with NSCLC. J Thorac Oncol. 2011; 6: 627-630. doi: 10.1097/JTO.0b013e31820a0ec0
49. Li X, Kaplun A, Lonardo F, et al. HDAc1 inhibition by maspin abrogates epigenetic silencing of GST-Pi in prostate carcinoma cells. Mol Can Res. 2011; 9(6): 733-745.
50. Weiner IS, Lonardo F, Johnson SC, Deppe G. Merkel cell carcinoma in a patient with non invasive vulvar Paget’s disease. AM J Obtet Gynecol. 2012; 207(1): e9-e11. doi: 10.1016/j.ajog.2012.03.028
51. Hillman GG, Gupta VS, Lonardo F, et al. Soy Isoflavones Protect Normal Lung Tissue from Radiation-Induced Injury . Journal of Thoracic Oncology. 2013; 8(11): 1356-1364. doi: 10.1016/j.radonc.2011.10.020
52. Hillman GG, Gupta VS, Hoogstra DJ, et al. Joiner: Differential Effect of Soy Isoflavones in Enhancing High Dose Radiotherapy and Protecting Lung Tissue in a Pre Clinical Model of Lung Carcinoma. Radiotherapy and Oncology. 2013.
53. SH Dzinic, A Kaplun, X Li, et al. Identification of an Intrinsic Motif Critical for Maspin Subcellular Localization and Function. PLoS One. 2013; 8(11): e74502.doi: 10.1371/journal.pone.0074502
54. Hillman GG, Lonardo F, Hoogstra DJ, et al. Axitinib Improves Radiotherapy in Murine Xenograft Lung Tumors. Translational Oncology. doi: 10.1016/j.tranon.2014.04.002
55. Lonardo F, Guan H, Dzinic S,Sheng S. Maspin Expression Patterns Differ in the Invasive vs. Lepidic Growth Pattern of Pulmonary Adenocarcinoma. Histopathology. 2014. doi: 10.1111/his.12485

Janelle Lyn Yorke, PhD

Senior Lecturer
School of Nursing, Midwifery and Social Work
University of Manchester
Room 5.320, Jean McFarlane University
University Place
Oxford Road
Manchester M13 9PL, UK

BiographyResearch InterestScientific ActivitiesPublications
Education


• (2006-2009) University of Salford PhD. Topic: Quantification of breathlessness using descriptors in cardiopulmonary disease]. Supervisor: Professor Paul Jones
• (2004-2005) Imperial College London Certificate of Advanced Study in Learning and Teaching (PGCE equivalent).
• (2000-2002) Australian Catholic University Masters of Research. Topic: Patients perceptions of pain management post cardiac surgery]. Supervisor: Professor Marianne Wallis
• (1996-1998) Australian Catholic University Post Graduate Diploma in Cardiothoracic Nursing
• (1988-1991) University of Western Sydney Diploma of Applied Science (Nursing).

Her research focuses on the assessment and self-management of complex symptoms.

AWARDS


• Travel Scholarship Awarded by: Asthma UK, 2010, European Respiratory Conference, Barcelona
• Travel Scholarship Awarded by: British Lung Foundation, 2009, European Respiratory Conference, Vienna
• Travel Scholarship Awarded by: Dyspnea-Central International Travel Award, 2009, USA
• Marjorie Simpson New Researcher of the Year Awarded by: Royal College of Nursing, 2007
• Elizabeth Yeo Best Oral Presentation Awarded by: Transplant Nurses Annual Conference, 2003
• Best Paper Awarded by: St Vincents Hospital Monograph, 2001
• Best Poster Presentation Awarded by: Transplant Nurses Association, 2001
• Peer Recognition Award Awarded by: St Vincents Hospital, 2001, Sydney
• Best Presentation voted by the audience Awarded by: St Vincents Nursing Research Symposium, 2001, Sydney
• Best Presentation voted by committee Awarded by: St Vincents Nursing Research Symposium, 2001, Sydney
• Research Scholarship Awarded by: St Vincents Nursing Research Unit, 2000
• Highly Commended - Post Graduate Diploma in Cardiothoracic Nursing Awarded by: Australian Catholic University


Membership Of Professional Bodies


• RGN - Registration with NMC (UK)
• British Thoracic Society - Nurse Advisory Group
• American Thoracic Society - member of Nursing Assembly Scientific committee 2011
• European Respiratory Society
• Royal College of Nursing Research Society – NW Regional Chair and New
• Researcher Award Chair of the judging panel

Peer reviewed Publications


1. Garrow A, Yorke J, et al . Systematic review of patient reported outcome measures for sleep in COPD. International Journal of COPD . 2014.
2. Yorke J. Management of breathlessness in advanced disease. J CommNurs.
3. Yorke J, Bundock S, Armstrong I. TheimPHact of living with pulmonary hypertension: a qualitative exploration. Nursing & Health Sciences. 2014.
4. PaudyalP, Hine P, Theadom A, et al. Written Emotional Disclosure for asthma. Cochrane Database Sys Rev. 2014.
5. Yorke J, Corris P, Gaine S, et al. emPHasis-10: development of a health-related quality of life measure for pulmonary hypertension. EurRespir J. 2014; 43: 1106-1113. doi: 10.1183/09031936.00127113
6. Yorke J, Spencer L, Kwong G, et al. Cross-Atlantic modification and validation of the - A Tool to Assess Quality of Life in Idiopathic Pulmonary Hypertension (ATAQ-cA). BMJ Open Respiratory Research. 2014. doi: 10.1136/bmjresp-2014-
7. Al Gamal E, Yorke J, , Al-Shwaiyat MK. Dyspnoea-12-Arabic: testing of an instrument to measure breathlessness in Arabic patients with COPD. Heart Lung. 2014; 43(3): 244-248. doi: 10.1016/j.hrtlng.2014.02.003
8. Yorke J, Armstrong I. Assessment of breathlessness in pulmonary hypertension: validation of the Dyspnoea-12. Eur J CardiovascNurs. 2013. doi: 10.1177/1474515113514891
9. Al Gamal E , Yorke J. Perceived breathlessness and psychological distress among patients with chronic obstructive pulmonary disease and their spouses. Nursing Health & Sciences. 2013. doi: 10.1111/nhs.12073
10. Armstrong I, Harries C, Rochnia N, Bundock S, Yorke J. The trajectory to diagnosis with pulmonary hypertension: a qualitative study. BMJ Open. 2012. doi: 10.1136/bmjopen-2011-000806
11. Molassiotis A, Cellis J, Wagland R, et al. The Manchester Cough in Lung Cancer scale: the development and validation of a new assessment tool. Journal of Pain and Symptom Management. 2012; 45(2): 179-190. doi: 10.1136/bmjopen-2011-000806
12. Yorke J, Brettle A, Molassiotis A. Non-pharmacological interventions for managing respiratory symptoms in lung cancer. Chronic Respiratory Disease. 2012 (2):117-129. doi: 10.1177/1479972312441632
13. Grant M, Cavanagh A, Yorke J. The impact of caring for those with COPD on carers psychological well-being: a narrative review. International Journal of Nursing Studies. 2012; 49(11): 1459-1471. doi: 10.1016/j.ijnurstu.2012.02.010
14. Al-Shair K, Muellerova H, Yorke J, et al. Examining fatigue in COPD: development, validity and reliability of a modified version of FACIT-F scale. Health Qual Life Outcomes. 2012; 10(1): 100. doi: 10.1186/1477-7525-10-100
15. Yorke J, Horton M, Jones PW. A critique of Rasch analysis for the development of health-related instruments. Journal of AdvancedNursing. 2012; 68(1):191-198. doi: 10.1111/j.1365-2648.2011.05723.x
16. Yorke J, Russell A, Swigris J, et al. Assessment of dyspnoea in asthma: validation of the Dyspnoea-12. Journal of Asthma. 2011; 48(6): 602-608. doi: 10.3109/02770903.2011.585412.
17. Yorke J, Swigris J, Russell AM, et al. Dyspnoea-12 is a valid and reliable measure of breathlessness in patients with interstitial lung disease. Chest. 2011; 139(1): 159-164. doi: 10.1378/chest.10-0693
18. Robson V, Yorke J, Lowe D, Rogers S. Randomised controlled feasibility trial on the use of medical grade honey following microvascular free tissue transfer to reduce the incidence of wound infection. Br J Oral Maxillofac Surg. 2011; 50(4): 321-327. doi: 10.1016/j.bjoms.2011.07.014
19. Yorke J, Jones PW, Swigris J. Development and validity testing of an IPF-specific version of the SGRQ (the SGRQ-I). Thorax . 2010; 65: 921-926. doi: 10.1136/thx.2010.139121
20. Yorke J, Moosavi S, Shuldham C, Jones PW. Quantification of dyspnoea using descriptors: Development and initial testing of the Dyspnoea-12. Thorax . 2010; 65(1): 21-26. doi: 10.1136/thx.2009.118521
21. Yorke J, Rochnia N,Walters S, et al. Maintenance rehabilitation for chronic obstructive pulmonary disease. Cochrane Database of Systematic Reviews. 2010; 11.
22. Swigris J, Yorke J, Sprunger D, Du BR, Fischer A. The impact of dyspnoea on patients with connective tissue disease-related ILD. Respiratory Medicine. 2010; 104(9): 1350-1355. doi:
23. Iley K, McInulty L, Jones I, Yorke J, Johnson M. Developing competence in cardiac care through the use of blended learning: course members and mentors accounts. Nurse Education Today. 2010; 31(4): 323-327. doi: 10.1016/j.nedt.2010.06.009
24. Theadom A, Smith H, Yorke J, et al. Written emotional disclosure for asthma. Cochrane Database of Systematic Reviews. 2009; 2. doi:
25. Shuldham C, Fleming S, Yorke J. Undertaking a systematic review: the road to successful completion. Journal of Research in Nursing. 2008; 13(4): 182-198. doi: 10.1177/1744987108093527
26. Yorke J, Cameron TE. Patients perceived care needs whilst waiting for a heart or lung transplant. Journal of Nursing and Healthcare of Chronic Illness. 2008); 17: 78-87. doi: 10.1111/j.1365-2702.2007.02078.x
27. Cowlard J, Carr S, Yorke J. Understanding adolescents adherence to their cystic fibrosis treatments. 2008.
http://www.cfww.org
28. Yorke J, Fleming S, Shuldham C. Psychological interventions for adults with asthma: A systematic review. Respiratory Medicine. 2007; 101: 1-4. doi: http://dx.doi.org/10.1016/j.rmed.2006.04.003
29. Yorke J, Fleming S, Shuldham C. A systematic review of psychological interventions for children with asthma. Paediatric Pulmonology. 2007; 42: 114-124. doi: 10.1002/ppul.20464
30. Yorke J, Parle M, James M, et al. Lung Transplantation in adolescents and young adults with cystic fibrosis. Progress in Transplantation. 2006; 16: 343-354.
31. Yorke J, Fleming SL, Shuldham CM. Psychological interventions for adults with asthma. Cochrane Database of Systematic Reviews. 2006; 1. doi: 10.1002/14651858.CD002982.pub3
32. Yorke J, Shuldham C. Family therapy for asthma in children. Cochrane Database of SystematicReviews. 2005; 2. doi:
33. Yorke J, Fleming S, Shuldham C. Psychological interventions for children with asthma. Cochrane Database of Systematic Reviews. 2005; 4. doi: doi: 10.1002/14651858.CD003272.pub2
34. Yorke J. Dyspnoea and Pain: an interesting analogy. Journal of Clinical Nursing. 2008; 17: 841-842. doi: 10.1111/j.1365-2702.2008.02299.x
35. Yorke J, Wallis M, McClean B. Patients perceptions of pain management following cardiac surgery in an Australian Critical Care Unit. Heart Lung. 2004; 33: 33-41. doi: http://dx.doi.org/10.1016/j.hrtlng.2003.09.002

Rasha Daabis, MD

Associate Professor of Chest Diseases
Faculty of Medicine
Alexandria University
Egypt

BiographyResearch InterestScientific ActivitiesPublications

• (2013-Present) Associate Professor of Chest Diseases, Faculty of Medicine, Alexandria University, Egypt
• (1998-2001) Resident in Department of Chest Diseases, Alexandria Main University Hospital, Egypt
• (6/2001) Master of Science in Chest Diseases and Phthisiology, Faculty of Medicine, Alexandria University, Egypt
• (11/2007) Doctorate degree in Chest Diseases and Phthisiology, Faculty of Medicine, Alexandria University, Egypt
• (2002-2008) Assistant Lecturer in Department of Chest Diseases, Faculty of Medicine, Alexandria University, Egypt
• (2008-2013) Assistant Professor (Lecturer) in Department of Chest Diseases, Faculty of Medicine, Alexandria University. Egypt
• (2013 to Present) Associate Professor in Department of Chest Diseases, Faculty of Medicine, Alexandria University. Egypt
• Pulmonary Consultant in the Andalusia (Alsalama ) Hospital. Alexandria. Egypt

Her research interests would be all fields of respiratory medicine especially obstructive lung diseases (COPD and asthma), sleep related breathing disorders, pulmonary rehabilitation and respiratory ICU.

MEMBERSHIPS


• The European Respiratory Society
• Alexandria Thoracic Association (ATA)
• The Egyptian Society of chest diseases and Tuberculosis
• Egyptian society of bronchology
• Scientific society of sleep and respiratory disorders


HONOURS, AWARDS


• The award of Professor Ali Reda El Henidi for the excellence in the Master of Science Degree in 2001
• The European Respiratory Society and the European Sleep Research Society award for outstanding abstracts for the abstract titled “Predictors of Anxiety and Depression in Patients with Obstructive Sleep Apnea” in the 2nd International Sleep and Breathing Conference. Berlin, Germany. 11 - 13 April 2013.
• The European Respiratory Society and the European Sleep Research Society award for outstanding abstracts for the abstract titled “Sleep Apnea in kidney Transplant Patients: clinical correlates and comparison with pretransplant patients” in the 2nd International Sleep and Breathing Conference. Berlin, Germany. 11 - 13 April 2013.

1. Daabis R. Prevalence of sleep apnea in patients with Acromegaly: analysis of cephalometric parameters by magnetic resonance imaging. Egyptian Journal of chest diseases and tuberculosis. 2010.
2. Zidan M, Daabis R, Essam H. Psychiatric comorbidity in COPD and its determinants. Egyptian Journal of Chest diseases and Tuberculosis. 2011.
3. Muawia S, Zidan M, Daabis R, Wagdy M. Association of CD40 genotyping and its protein expression with airway inflammatory diseases. Journal of Molecular Biomarkers and Diagnosis. 2011; 2(4): 115. doi: 10.4172/2155-9929.1000115
4. Daabis R. Relation between body mass index and control of bronchial asthma among Egyptian adults with asthma. Egyptian Journal of Chest diseases and Tuberculosis. 2011.
5. Daabis R, Gharraf H. Predictors of anxiety and depression in patients with obstructive sleep apnea. Egyptian Journal of Chest diseases and Tuberculosis. 2012. doi: 10.1016/j.ejcdt.2012.10.032
6. Khalil Y, Ibrahim E, Daabis R, Nahas EE. Sleep-Related Breathing Disorders in Patients with Schistosomal Cor–Pulmonale. Egyptian J of Chest diseases and Tuberculosis. 2012. doi: 10.1016/j.ejcdt.2012.10.021
7. Daabis R, Gohary EE. Sleep Apnea in kidney Transplant Patients: clinical correlates and comparison with pretransplant patients . Egyptian J of Chest diseases and Tuberculosis. 2012. doi: 10.1016/j.ejcdt.2012.08.01
8. Daabis R, Banawan L, Rabea A, Elnakedy A, Sadek A. Relevance of Chest Sonography in the Diagnosis of Acute Respiratory Failure: Comparison with Current Diagnostic Tools in Intensive Care Units. Egyptian J of Chest diseases and Tuberculosis. 2014. doi: 10.1016/j.ejcdt.2014.05.005
9. Daabis R. Prevalence of antithyroid peroxidase antibodies (anti-TPO) in patients with bronchial asthma. Egyptian journal of obesity diabetes and endocrinology. 2014.
10. Daabis R, Muawia S, Ahmed A, El-Shahat M, Youssef A, Fekry T. Αlpha-1 antitrypsin gene polymorphism in the Egyptian population: association with obstructive lung diseases.Pulm Res Respir Med Open J. 2014; 1(1): 13-20. doi: 10.17140/PRRMOJ-1-103
11. Daabis R. Allergic rhinitis and asthma: The united airways disease. Pulm Res Respir Med Open J. 2016; 3(2): e3-e4. doi: 10.17140/PRRMOJ- 3-e005

Makoto Hoshino, MD, PhD

Professor
Department of Internal Medicine
Division of Clinical Allergy
International University of Health and Welfare
Atami Hospital
13-1 Higashikaigan-cho, Atami
Shizuoka 413-0012, Japan

BiographyResearch InterestScientific ActivitiesPublications
EDUCATIONAL QUALIFICATIONS


• (1988) PhD, Toho University School of Medicine (Thesis: Breath-by-breath analysis of airway hypersensitivity and ventilatory parameters in bronchial asthma)
• (1988) Graduate from Toho University School of Medicine master course
• (1984) MD, Toho University School of Medicine


PROFESSIONAL EXPERIENCES


• (2015-Present) Professor, Division of Clinical Allergy, Department of Internal Medicine, Atami Hospital, International University of Health and Welfare
• (2011-2015) Professor, Department of Respiratory Medicine, Atami Hospital International University of Health and Welfare
• (2009-2011) Associate Professor, Department of Respiratory Medicine, Atami Hospital International University of Health and Welfare
• (2002-2009) Assistant Professor, Division of Respiratory and Infectious Diseases, Department of Internal Medicine, St. Marianna University School of Medicine
• (1991-2002) Instructor, Second Department of Internal Medicine, Toho University School of Medicine
• (1984-1991) Medical Staff in Second Department of Internal Medicine, Toho University School of Medicine
• (1984) Passed the National Board Examination

His research interests include: Cytology, Cell culture, Pathology&Immunology, Immunostaining, In situ hybridization and Clinical technique in Respirology, Pulmonary function tests, Bronchofiberscope, Bronchial biopsy, Broncho-alveolar lavage.

AWARDS


• (1999) Japan Allergy Foundation Award for Outstanding Research Achievement
• (1999) Research Training Award for Takeshi-Yanase
• (2001) AstraZeneca Asthma Research Award
• (2012) Fukuchi Award, Asian Pacific Society of Respirology


MEMBERSHIPS


• Japanese Society of Internal Medicine
• Japanese Society of Allergology
• Japanese Respiratory Society
• Japanese Society for Respiratory Endoscopy
• The Japan Lung Cancer Society
• European Respiratory Society
• Fellowship in the American College of Chest Physicians (FCCP)

Haiyan Tong, MD, PhD

Research Biologist/Principal Investigator
Clinical Research Branch
Environmental Public Health Division
National Health and Environmental Effects Research Laboratory
US Environmental Protection Agency
Research Triangle Park, NC, USA

BiographyResearch InterestScientific ActivitiesPublications

Dr. Tong is a Research Biologist (Principal Investigator) with the United States Environmental Protection Agency (US EPA), National Health and Environmental Effects Research Laboratory, Environmental Public Health Division in Research Triangle Park, North Carolina. She received her MD from China Medical University and her PhD of Human Physiology from the University of Florida in 1998. She finished her post-doctoral training at the National Institute of Environmental Health Sciences, National Institutes of Health. She was on faculty at Duke University and University of North Carolina at Chaple Hill, in North Carolina. She has won several national and international awards for research on environmental stress and air pollution impacts on human health. She has published thirty high impact peer-reviewed journal papers and gave numerous invited presentations in international conferences.

Her research interests include: The cardiopulmonary effects of air pollution exposure in both humans and animals, and the mechanism of cardiopulmonary toxicity of nanoparticles and ambient air pollution particles exposure in animals. Currently, she is leading several collaborative studies to examine the cardiopulmonary effects of multi-pollution exposure in animals using cardiac ischemia/reperfusion model. She also examines the protective effects of dietary supplements on the adverse health effects of air pollution exposure in human volunteers.

MEMBERSHIPS


• American Heart Association
• American Physiological Society
• Society of Taxicology


HONORS


• (1995) International Student Academic Award, University of Florida
• (1996-1998) American Heart Association Predoctoral Fellowship
• (1998) Graduate Student Travel Award, University of Florida
• (1998-2001) National Institutes of Health (NIH) Intramural Research Training Award
• (2001) National Institutes of Health (NIH) Award of Merit
• (2002) National Institutes of Health (NIH) Fellows Award for Research Excellence
• (2003) Young Investigator Award, International Society for Heart Research (North American Section)
• (2003) American Heart Association New Investigator Award
• (2010) US EPA Scientific and Technological Achievement Awards (STAA)
• (2012) US EPA Scientific and Technological Achievement Awards (STAA)
• (2013) US EPA Scientific and Technological Achievement Awards (STAA)
• (2014) US EPA Pathfinder Innovation Projects (PIP4) Award

1. Tong H, Lakhdir F, Wood CE. Endogenous prostanoids modulate the ACTH and AVP responses to hypotension in late-gestation fetal sheep. American Journal of Physiology. 1998; 275: R735-R741.
2. Tong H, Richards E, Wood CE. Prostaglandin endoperoxide synthase-2 abundance is increased in brain tissues of late-gestation fetal sheep in response to cerebral hypoperfusion. Journal of the Society for Gynecologic Investigation. 1999; 6(3): 127-135.
3. Wood CE, Tong H. Central nervous system regulation of reflex responses to hypotension during fetal life. American Journal of Physiology. 1999; 277: R1541-R1552.
4. Tong H, Wood CE. Indomethacin attenuates the cerebral blood flow response to hypotension in late-gestation fetal sheep. American Journal of Physiology. 1999; 277: R1268-R1273.
5. Tong H, Dhillon H, Wood CE. Induction of PGHS-2 mRNA in response to cerebral hypoperfusion in late-gestation fetal sheep. Prostaglandins and other Lipid Mediators. 2000; 62: 165-172. doi: 10.1016/S0090-6980(00)00064-2
6. Tong H, Chen W, London RE, Murphy E, Steenbergen C. Preconditioning enhanced glucose uptake is mediated by p38 MAP kinase not by phosphatidylinositol-3-kinase. Journal of Biological Chemistry. 2000; 275(16): 11981-11986. doi: 10.1074/jbc.275.16.11981
7. Tong H, Chen W, Steenbergen C, Murphy E. Ischemic preconditioning activates phosphatidylinositol-3-kinase upstream of protein kinase C. Circulation Research. 2000; 87(4): 309-315. doi: 10.1161/01.RES.87.4.309
8. Lakhdir F, Tong H, Wood CE. Baroreceptor and prostanoid control of fetal renal cortical blood flow and plasma renin activity. Reproduction, Fertility and Development. 2001; 13: 119-124. doi: 10.1071/RD00101
9. Tong H, Gridley KE, Wood CE. Induction of immunoreactive PGHS-1, PGHS-2 and Fos in response to cerebral hypoperfusion in late-gestation fetal sheep. The Journal of the Society for Gynecologic Investigation. 2002; 9(6): 342-350. doi: 10.1177/107155760200900604
10. Tong H, Imahashi K, Steenbergen C, Murphy E. Phosphorylation of glycogen synthase kinase-3beta during preconditioning through a phosphatidylinositol-3-kinase-dependent pathway is cardioprotective. Circulation Research. 2002; 90: 377-379. doi: 10.1161/01.RES.0000012567.95445.55
11. Murphy E, Tong H, Steenbergen C. Preconditioning: is the akt-ion in the pi3k pathway? Journal of Molecular and Cellular Cardiology. 2003; 35(9): 1021-1025. doi: 10.1016/S0022-2828(03)00233-5
12. Tong H, Rockman HA, Koch WJ, Steenbergen C, Murphy E. G protein-coupled receptor internalization signaling is required for cardioprotection in ischemic preconditioning. Circulation Research. 2004; 94: 1133-1141. doi: 10.1161/01.RES.0000126048.32383.6B
13. Tong H, Bernstein D, Murphy E, Steenbergen C. The role of beta-adrenergic receptor signaling in cardioprotection. FASEB Journal. 2005; 19(8): 983-985. doi: 10.1096/fj.04-3067fje
14. Cho SH, Tong H, McGee JK, Baldauf RW, Krantz QT, Gilmour MI. Comparative toxicity of size-fractionated airborne particulate matter collected at different distances from an urban highway. Environmental Health Perspectives. 2009; 117(11): 1682-1689. doi: 10.1289/ehp.0900730
15. Tong H, McGee JK, Saxena RK, Kodavanti UP, Devlin RB, Gilmour MI. Influence of acid functionalization on the cardio-pulmonary toxicity of carbon nanotubes and carbon black particle in mice. Toxicology and Applied Pharmacology. 2009; 239(3): 224-232. doi: 10.1016/j.taap.2009.05.019
16. Tong H, Cheng WY, Samet JM, Gilmour MI, Devlin RB. Differential cardiopulmonary effects of size-fractionated ambient particulate matter in mice. Cardiovascular Toxicol. 2010; 10(4): 259-267. doi: 10.1007/s12012-010-9082-y
17. Cheng, WY, Tong H, Miller EW, et al. An integrated imaging approach to the study of oxidative stress generation by mitochondrial dysfunction in living cells. Environmental Health Perspectives. 2010; 118(7): 902-908. doi: 10.1289/ehp.0901811
18. Zhou RH, Vendrov AE, Tchivilev I, et al. Mitochondrial oxidative stress in aortic stiffening with age. Arterioscler Thromb Vasc Biol. 2012; 32: 745-755. doi: 10.1161/ATVBAHA.111.243121
19. Tong H, Rappold AG, Diaz-Sanchez D, et al. Omega-3 fatty acid supplementation attenuates particulate air pollution induced cardiac effects and lipid changes in healthy middle-aged adult volunteers. Environmental Health Perspectives. 2012; 120(7): 952-957. doi: 10.1289/ehp.1104472
20. Ghio AJ, Tong H, Soukup JM, et al. Sequestration of mitochondrial iron by silica particles initiates a biological effect. American Journal of Physiology Lung Cell Mol Physiol. 2013; 305(10): L712-L724. doi: 10.1152/ajplung.00099.2013
21. McIntosh-Kastrinsky R, Diaz-Sanchez D, Sexton K, et al. Photochemically altered air pollution mixtures and contractile parameters in isolated murine hearts before and after ischemia. Environmental Health Perspectives. 2013; 121(11-12): 1344-1348. doi: 10.1289/ehp.1306609
22. Ghio A, Tong H, Soukup J, et al. Biological effects of desert dust in respiratory epithelial cells and a murine model. Inhalation Toxicology. 2014; 26(5): 299-309. doi: 10.3109/08958378.2014.888109
23. Tong H, Rappold AG, Caughey M, et al. Cardiovascular effects caused by increasing concentrations of diesel exhaust in middle-aged healthy GSTM1 null human volunteers. Inhalation Toxicology. 2014; 26(6): 319-326. doi: 10.3109/08958378.2014.889257
24. Kim YH, Tong H, Daniels M, et al. Cardiopulmonary toxicity of peat wildfire particulate matter and the predictive utility of precision cut lung slices. Particle and Fibre Toxicology. 2014; 11: 29. doi: 10.1186/1743-8977-11-29
25. Kurhanewicz N, McIntosh-Kastrinsky R, Tong H, Walsh L, Farraj AK, Hazari MS. Ozone co-exposure modifies cardiac responses to fine and ultrafine ambient particulate matter in mice: concordance of electrocardiogram and mechanical responses. Particle and Fibre Toxicology. 2014; 11: 54. doi: 10.1186/s12989-014-0054-4
26. Wages P, Silbajoris R, Speen AM, et al. Role of H2O2 in the Oxidative Effects of Zinc Exposure in Human Airway Epithelial Cells. Redox Biology. 2014; 3: 47-55. doi: 10.1016/j.redox.2014.10.005
27. Tong H, Rappold AG, Caughey M, et al. Olive oil supplementation attenuates endothelial dysfunction caused by concentrated ambient particulate matter exposure in healthy human volunteers. Environmental Health Perspectives. 2015.


BOOK CHAPTERS AND CONFERENCES


1. Murphy E, Tong H, Steenbergen C. A role for the phosphatidylinositol-3-kinase pathway in preconditioning. Myocardial ischemia and preconditioning in progress in experimental cardiology. In: Dhalla NS, Takeda N, Singh M, Lukas A, eds. Kluwer Academic Publishers, Boston, MA. 2003; 2003(6): 275-282.
2. Steenbergen C, Tong H, Murphy E. PI3 kinase and cardioprotection. Cardiovasc J S Afr. 2004; 15(4 Suppl 1): S4.

Rakesh K. Mishra, PhD

Department of Pharmacology College of Medicine
University of Illinois
Autoimmune Disease Center
The Feinstein Institute for Medical Research
835 S. Wolcott Ave, Chicago, IL 60612, USA

BiographyResearch InterestScientific ActivitiesPublications
EDUCATIONAL QUALIFICATIONS


• (2002) MSc-Biochemistry, APS University, Rewa (MP), India
• (2011) PhD-Biochemistry, Department of Biochemistry, V.P. Chest Institute, University of Delhi, Delhi, India


PROFESSIONAL EXPERIENCES


• Postdoctoral Fellow, Icahn School of Medicine at Mount Sinai New York, NY, USA
• Postdoctoral fellow Department of Pharmacology College of Medicine University of Illinois at Chicago, USA
• Postdoctoral fellow, Department of Pediatrics, University of Illinois at Chicago, USA

His research focuses on to understand the role of co-stimulatory molecules in target organ inflammation. Co-stimulatory receptors are involved in trafficking of immune cells to target organs. Normally, immune cells are sequestered in the lymphoid organs, such as the spleen and lymph nodes. When they traffic to a non-lymphoid organ, such as the kidney, they can induce inflammation. Recent work therefore focuses on lupus nephritis and the role of immune cell activation in kidney damage so as to understand the molecular basis for cell migration to the kidney and for resolution of inflammation after remission inducing therapies. Other project he is working on whether the deficiency or overexpression of circadian master transcriptional regulatory protein CLOCK/BMAL1 have any impact on lupus severity.

AWARDS


• UGC-Research Scholarship for PhD-Student by University of Delhi
• Acbicon 2007 Student Scholarship (2007)
• Bursary awarded by European Respiratory Society, for attending the ERS Lung Science Conference, Estoril, Portugal (2009)
• Bursary (ERS Young Scientist Sponsorship) awarded by European Respiratory Society for attending the ERS Vienna, Austria (2009)
• Bursary awarded by FABLS (Fluoresence application in biotechnology and life science) Society (2009)
• ERS Young Scientist Sponsorship for attending the Lung Science Conference (2010)
• Travel award by the Aspen Allergy and Asthma Society, USA Aspen Allergy Conference 2010, Colorado, USA (2010)
• Travel award by the Physiological Society, UK for attending the young scientists the next generation of asthma & allergy research London South Bank University, London, UK (2010)
• Travel award by the Salk Institute for the Biological Studies, for participation and paper presentation in the 2010 Protein Phosphorylation & Cell Signaling meeting, La Jolla, San Diego, CA (2010)
• Travel fellowship awarded by CSHL (Cold Spring Harbor Laboratory), 2012, CSHL Workshop on Leadership in BioScience New York, USA
• Best Poster Presentation and Travel Award 3rd Conference on translational medicine on pathogenesis and therapy of immune-mediated diseases, Focus on inflammation, Milan, Italy


MEMBERSHIPS


• European Respiratory Society (ERS)
• American Thoracic Society (ATS)
• Biotech Society of India (BSI)
• Indian College of Allergy, Asthma and Immunology
• American Society for Biochemistry and Molecular Biology (ASBMB)

1. Mishra RK, Kulshrestha R, Chhabra SK, Bansal SK. Changes in Protein Kinase C Activity in Airway Smooth Muscles During the Development of Airway Hyperreactivity in Guinea Pigs: A Preliminary Study. Indian Journal of Clinical Biochemistry. 2007; 22: 476.
2. Singh U, Mishra RK, Kumar A, et al. Calreticulin transacetylase catalyzed modification of the TNF-α mediated pathway in the human peripheral blood mononuclear cells by polyphenolic acetates . Chemico-Biological Interactions. 3. 2010; 185(3): 263-270. doi: 10.1016/j.cbi.2010.02.025
4. Reddy AB, Tammali R, Mishra RK, Srivastava S, Srivastava SK. Aldose reductase deficiency protects sugar-induced lens opacification in rats. Chem Biol Interact. 2011; 30: 191. doi: 10.1016/j.cbi.2011.02.028
5. Yadav UC, Mishra RK, Aguilera-Aguirre L, et al. Prevention of Allergic Rhinitis by Aldose Reductase Inhibition in a Murine Model. Inflamm Allergy Drug Targets. 2013. doi: 10.2174/1871528111312030004#sthash.ksVijCBx.dpuf
6. Mishra RK. Changes in phosphoinositide turnover in airway smooth muscles and blood lymphocytes in ova sensitized guinea pig model of asthma. Pulm Res Respir Med Open J. 2016; 3(1): 10-18. doi: 10.17140/PRRMOJ-3-125