Editorial Board


Neuro - Open Journal

Mayur S. Parmar, PhD

Researcher
Appel Alzheimers Disease Research Institute
Feil Family Brain and Mind Research Institute (BMRI)
Weill Cornell Medical College of Cornell University
New York, USA

BiographyResearch InterestScientific ActivitiesPublications
EDUCATION


• (2014) Doctor of Philosophy (PhD) in Pharmacology & Toxicology Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA, USA
• (2008) Master of Science in Pharmacology & Toxicology Department of Pharmaceutical Sciences, Long Island University, Brooklyn, NY, USA
• (2004) Bachelor of Pharmacy Sardar Patel University, Gujarat, India

His professional research interests includes: Multidisciplinary areas of biological sciences, including Pharmacology, Toxicology, and molecular/cellular biology with a broad research experience in Neuroscience. He has been involved in CNS research focused on understanding the pathological mechanisms (molecular, genetic, and cellular basis) underlying the development of neurodegenerative diseases (Alzheimers and Parkinson) and potential therapeutic intervention to halt the progression of disease. Currently, he has been actively involved in Alzheimers disease research focused on studying the effect of ApoE isoforms on amyloid and tau pathology in Alzheimers disease. He has been working with several transgenic mouse model of AD, both amyloid and tau, and has been looking into several signaling pathways involved in amyloid clearance/degradation. He has wide experience in performing stereotaxic surgeries to infuse neurotoxins, Adeno-associated virus mediated gene delivery and pharmacological agents in different brain regions of mouse model.

HONORS, AWARDS AND AFFILIATIONS


• (2007) Rho Chi Award for excellence in Pharmaceutical Sciences
• (2007-2013) Graduate Research Assistantship at Duquesne University
• (2012) Vice-President of Graduate Professional Student Council, Duquesne University
• (2012-2013)Member of Presidents Advisory Council on Diversity, Duquesne University
• (2005-2007) Graduate Research Assistantship at Long Island University
• Society of Neuroscience (SFN)
• Society of Toxicology (SOT)
• American Association of Pharmaceutical Scientists (AAPS)
• Registered Pharmacist (Pharmacy Council of India, India)

1. Parmar MS, Jaumotte JD, Wyrostek SL, Zigmond MJ, Cavanaugh JE. The role of ERK 1, 2, and 5 in dopamine neuron survival during aging. Neurobiology of Aging. 2014; 35(3): 669-679. doi: 10.1016/j.neurobiolaging.2013.09.031
2. Rose KM, Parmar MS, Cavanaugh JE. Dietary supplementation with resveratrol protects against striatal dopaminergic deficits produced by in utero LPS exposure. Brain Research. 2014; 1573: 37-43. doi: 10.1016/j.brainres.2014.05.028
3. Paul SM. Gene delivery of apoE2 reduces brain amyloid burden in apoE4-target replacement APP.PS1 transgenic mice. Society for Neuroscience. 2014.
4. Syed I, Rathod J, Parmar M, Corcoran GB, Ray SD. Matrix metalloproteinase-9,-10, and-12, MDM2 and p53 expression in mouse liver during dimethylnitrosamine-induced oxidative stress and genomic injury. Molecular and Cellular Biochemistry. 2012; 1-11.
5. Shah K, Parmar M, Ray SD. Ros-mediated oxidative stress influence anti-apoptotic genes and cyt c release in hyperglycemic mouse kidneys to initiate late nephropathic complications. Diabetes-Metabolic Syndrome. Free Radical Biology and Medicine. 2009; 47(1): S87.
6. Parmar M, Ismail S, Ray SD. A Triple Bioflavonoid Mixture Modulates Pro- and Anti-Apoptotic Gene Expression. During Streptozocin (STZ)-Induced Oxidative Stress in the Mouse Liver. The Toxicologist. 2008; 97(1).
7. Ray SD, Parmar M, Syed I, et al. Long term exposure effect of a unique metabolic nutrition system containing a diverse group of phytochemicals on serum chemistry and genomic and non‐genomic changes in the liver of female B6C3F1 mice. Phytotherapy Research. 2008; 22(4): 458-471. doi: 10.1002/ptr.2337
8. Parmar M, Syed I, Patel C, et al. Dietary supplement Thermoplus® reduces the level of oxidative stress and stabilizes the genomic integrity in the liver and kidneys of Fisher 344 rats. American College of Nutrition Annual meeting, Orlando, Florida. 2007.
9. Bulku E, Rathod J, Ismail S, Parmar M, Ray SD. Antiapoptotic and Antinecrotic Properties of Bioflavonoids Curcumin and Rutin. American Journal of Pharmaceutical Education. 2007; 71(3): 60.
10. Rathod J, Ismail S, Parmar M, Ray SD. Modulation of matrix metalloproteases (MMPs) and MDM2 during acute dimethylnitrosamine (DMN)-induced nephrotoxicity in mice. The FASEB Journal. 2007; 21: 730-732.


BOOK CHAPTERS


1. Parmar MS. Dicarboxylic Acid. In: Wexler P, ed. Encyclopedia of Toxicology. 3rd ed. Elsevier Inc, Academic Press; 2014; 2: 76-79.
2. Parmar MS. Methylglyoxal. In: Wexler P, ed. Encyclopedia of Toxicology. 3rd ed vol 3. 2014 Elsevier Inc, Academic Press; 302-305.

Roberto Maniglio, PhD

Associate Professor of Clinical Psychology
Department of Pedagogic, Psychological and Didactic Sciences
University of Salento
Piazzetta Tancredi, 73100 Lecce LE, Italy

BiographyResearch InterestScientific ActivitiesPublications

Dr. Maniglio is an Associate Professor of Clinical Psychology. He is a Psychotherapist, a Criminologist and Forensic Psychopathologist, and a court-appointed expert. He teaches at the University of Salento, Lecce, Italy.

His research interests include: The etiology and prevalence of psychiatric disorders, family dysfunction, parenting, intimate partner violence, child abuse, sexual crimes, victimization, and aggression.

Scientific Associations/Societies Membership

• American Society of Addiction Medicine
• Association for Middle Level Education
• British Science Association
• Division of Evaluation, Measurement, & Statistics (Division 5 American Psychological Association)
• International Association for Criminal Psychology
• International Association for Health and Learning
• International Corrections and Prisons Association
• International Early Psychosis Association
• Ordine Nazionale degli Psicologi [Italian Psychological Association]
• Società Italiana di Criminologia [Italian Society of Criminology]
• Society for Qualitative Inquiry in Psychology
• Society for the Psychology of Women (Division 35 American Psychological Association)

Publications in peer-review international journals:

1. Maniglio R, Innamorati M. Psychosocial correlates of adolescent cannabis use: data from the Italian subsample of the second International Self-Reported Delinquency study. Journal of Addictive Diseases. 2014; 33: 210-220. doi: 10.1080/10550887.2014.950023.
2. Maniglio R. Significance, nature, and direction of the association between child sexual abuse and conduct disorder: a systematic review. Trauma, Violence, & Abuse. 2014. doi: 10.1177/1524838014526068
3. Maniglio R. Prevalence of sexual abuse among children with conduct disorder: a systematic review. Clinical Child and Family Psychology Review. 2014; 17: 268-282. doi: 10.1007/s10567-013-0161-z.
4. Maniglio R, Gusciglio F, Lofrese V, Belvederi Murri M, Tamburello A, Innamorati M. Biased processing of neutral facial expressions is associated with depressive symptoms and suicide ideation in individuals at risk for major depression due to affective temperaments. Comprehensive Psychiatry. 2014; 55: 518-525. doi: 10.1016/j.comppsych.2013.10.008
5. Maniglio R. Prevalence of child sexual abuse among adults and youths with bipolar disorder: a systematic review. Clinical Psychology Review. 2013; 33: 561-573. doi: 10.1016/j.cpr.2013.03.002
6. Maniglio R. The impact of child sexual abuse on the course of bipolar disorder: a systematic review. Bipolar Disorders: An International Journal of Psychiatry and Neurosciences. 2013; 15: 341-358. doi: 10.1111/bdi.12050
7. Maniglio R. Child sexual abuse in the etiology of anxiety disorders: a systematic review of reviews. Trauma, Violence, & Abuse. 2013; 14: 96-112. doi: 10.1177/1524838012470032
8. Maniglio R. The role of parent-child bonding, attachment, and interpersonal problems in the development of deviant sexual fantasies in sexual offenders. Trauma, Violence, & Abuse. 2012; 13: 83-96. doi: 10.1177/1524838012440337
9. Maniglio R. The role of childhood trauma, psychological problems, and coping in the development of deviant sexual fantasies in sexual offenders. Clinical Psychology Review. 2011; 31: 748-756. doi: 10.1016/j.cpr.2011.03.003
10. Maniglio R. The role of child sexual abuse in the etiology of suicide and non-suicidal self-injury. Acta Psychiatrica Scandinavica. 2011; 124: 30-41. doi: 10.1111/j.1600-0447.2010.01612.x
11. Maniglio R. The role of child sexual abuse in the etiology of substance-related disorders. Journal of Addictive Diseases. 2011; 30: 216-228. doi: 10.1080/10550887.2011.581987
12. Carabellese F, Maniglio R, Greco O, Catanesi R. The role of fantasy in a serial sexual offender: a brief review of the literature and a case report. Journal of Forensic Sciences. 2011; 56: 256-260. doi: 10.1111/j.1556-4029.2010.01536.x.
13. Maniglio R. Child sexual abuse in the etiology of depression: a systematic review of reviews. Depression and Anxiety. 2010; 27: 631-642. doi: 10.1002/da.20687.
14. Maniglio R. The role of deviant sexual fantasy in the etiopathogenesis of sexual homicide: a systematic review. Aggression and Violent Behavior. 2010; 15: 294-302. doi: 10.1016/j.avb.2010.02.001
15. Maniglio R. The impact of child sexual abuse on health: a systematic review of reviews. Clinical Psychology Review. 2009; 29: 647-657. doi: 10.1016/j.cpr.2009.08.003.
16. Maniglio R. Severe mental illness and criminal victimization: a systematic review. Acta Psychiatrica Scandinavica. 2009; 119: 180-191. doi: 10.1111/j.1600-0447.2008.01300.x
17. Maniglio R. The hooligan’s mind. Journal of Forensic Sciences. 2007; 52: 204-208. doi: 10.1111/j.1556-4029.2006.00315.x


National journals with peer-review:

1. Greco O. e Maniglio R. The psychological effects of child sexual abuse: a systematic review of the literature. Italian Review of Criminology. 2009; 1: 1-16.
2. Greco O. e Maniglio R. The parenting support in problem situations. The Family. 2009; 250: 6-19.
3. Greco O. e Maniglio R. The "child abuse" in the light of international literature. Studies and Research. 2008; X: 16.
4. Greco O. e Maniglio R. Pregnancy and childbirth. Psychopathological risk and intervention strategies. Studies and Research. 2008; X(15): 123-142.
5. Greco O. e Maniglio R. Mental illness and crime. Italian Review of Criminology. 2007; 1: 113-133.
6. Greco O. e Maniglio R. The parental alienation syndrome. The Family. 2007; 241: 30-36.
7. Maniglio R. Fans and ultras. A cognitive model of typhoid and violence. Clinical cognitivism. 2006; 3(1): 1-13.
8. Greco O. e Maniglio R. Mental disorders and parenting skills in intergenerational perspective. The Family. 2004; 224: 43-54.
9. Maniglio R. Attachment and antisocial personality disorder. "Parental Bonding" in subjects with antisocial disorder. Review of Psychotherapy, Hypnosis, Psychosomatic Medicine and Forensic Psychopathology. 2004; 9(1): 75-86.


Local journals without peer-review:

10. Pavone G. e Maniglio R. Effectiveness of the legal instruments in the repression of hooliganism. Notebooks. 2010; X(2): 228-249.
11. Maniglio R. Comorbid psychiatric disorders and substance use. Empirical contribution on Personality Disorders in drug addicts. Psychiatry in Puglia and Basilicata. 2004; X(16): 83-86.
12. Greco O. e Maniglio R. Post Traumatic Stress Disorder from bullying and biological damage. Psychiatry in Puglia and Basilicata. 2004; X (15): 52-55.
13. Maniglio R., Carofalo S. e Greco O. Nicotine addiction. Results of a search. Salento Doctor. 2004; XXVII (4-5-6): 18-21.
14. Greco O, Maniglio R. Addiction and parenting. Controversial. 2004; 0: 20-21.

Ramesh K. Agarwal, PhD

William Palm Professor of Engineering
Department of Mechanical Engineering and Materials Science
Washington University
Campus Box 1185
St. Louis, MO 63130-4899, USA

BiographyResearch InterestScientific ActivitiesPublications

Dr. Agarwal is the William Palm Professor of Engineering in the Department of Mechanical Engineering and Materials Science at Washington University in St. Louis. From 1994 to 2001, he was the Sam Bloomfield Distinguished Professor and Executive Director of the National Institute for Aviation Research at Wichita State University in Kansas. From 1978 to 1994, he was the Program Director and McDonnell Douglas Fellow at McDonnell Douglas Research Laboratories in St. Louis. Dr. Agarwal received PhD in Aeronautical Sciences from Stanford University in 1975, MS in Aeronautical Engineering from the University of Minnesota in 1969 and B.S. in Mechanical Engineering from Indian Institute of Technology, Kharagpur, India in 1968. Over a period of 35+ years, he has worked in various areas of Computational Science and Engineering - Computational Fluid Dynamics (CFD), Computational Materials Science and Manufacturing, Computational Electromagnetics (CEM), Neuro-Computing, Control Theory and Systems, and Multidisciplinary Design and Optimization. He is the author and coauthor of over 460 publications. He has given many plenary, keynote and invited lectures at various national and international conferences worldwide in over fifty countries. Dr. Agarwal continues to serve on many academic, government, and industrial advisory committees.

His research interests include: Computing and Control of Neurological Systems and Networks.

PROFESSIONAL MEMBERSHIPS


• Institute of Electrical and Electronics Engineers (IEEE)
• American Association for Advancement of Science (AAAS)
• American Institute of Aeronautics and Astronautics (AIAA)
• American Physical Society (APS)
• American Society of Mechanical Engineers (ASME)
• Royal Aeronautical Society
• Chinese Society of Aeronautics and Astronautics (CSAA)
• Society of Manufacturing Engineers (SME)
• American Society for Engineering Education (ASEE)


AWARDS


He has received many prestigious honors and national/international awards from various professional societies and organizations for his research contributions.

1. Agarwal RK. Computational Fluid Dynamics for Whole Body Aircraft. McGraw Hill Encyclopedia of Science. 2000. doi: 10.1146/annurev.fluid.31.1.125
2. Wendl MC, Agarwal RK. Couette Flow Profiles for Two Non-Classical Taylor-Couette Cells. ASME Journal of Fluids Engineering. 2000. doi: 10.1115/1.483277
3. Shue SP, Agarwal RK. Extension of Nonlinear Kalman Filter Theory for Nonlinear Wing Rock Motion, AIAA 98-4310. Asian Journal of Control. 2000; 2(1): 42-49.
4. Nho K, Agarwal RK. Automatic Landing System Design Using Fuzzy Logic. Journal of Guidance, Control, and Dynamics. 2000; 23(2): 298-304. doi: 10.2514/2.4522
5. Sh P, Agarwal RK, EK Boukas, Shue SP. Robust H. State Feedback Control of Discrete Time-Delay Linear Systems with Norm-Bounded Uncertainty. International Journal of Systems Science. 2000; 31(4): 409-415.
6. Pesonen U, Agarwal RK, Laine S. A Fast and Robust Vicous/Inviscid Interaction Code for Wing Flowfield Calculations, AIAA Paper 99-3139. Journal of Aircraft. 2000; 37(4): 730-733.
7. Sh P, Boukas EK, Agarwal RK. Robust Control for Markovian Jumping Discrete-Time Systems. International Journal of Systems Science. 1999; 30(8): 787-797. doi: 10.1080/002077299291912
8. Shue SP, Agarwal RK, Sh P. Nonlinear H. Method for Control of Wing Rock Motion. Journal of Guidance, Control and Dynamics. 23(1): 2000; 60-68.
9. Agarwal RK. Computational Fluid Dynamics of Whole-Body Aircraft. Annual Review of Fluid Mechanics. 1999; 31: 125-169. doi: 10.1146/annurev.fluid.31.1.125
10. Agarwal RK, Halt DW. A Compact High-Order Unstructured-Grids Method for the Solution of Euler Equations. International Journal of Numerical Methods in Fluids. 1999; 31: 121-147. doi: 10.1002/(SICI)1097-0363(19990915)31:1<121::AID-FLD959>3.0.CO;2-S
11. Agarwal RK. Parallel Implementations of a Compact High Order Maxwell Solver. Parallel Computational Fluid Dynamics, North Holland, NY. 1999; 327-336.
12. Agarwal RK, Augustinias J. A Characteristics-Based Box Scheme for Compressible Eight-Wave Structure Ideal MHD Equations. Computational Fluid Dynamics Journal. 1999; 8(2): 170-177.
13. Sh P, Shue SP, Agarwal RK. Worst Case Control for Discrete-Time Uncertain Nonlinear Systems. Journal of Guidance, Control and Dynamics. 1999; 22(6): 911-914. doi: 10.2514/2.4472
14. Shue SP, Agarwal RK. Design of Automatic Landing Systems Using Mixed H2/H Control. Journal of Guidance, Control and Dynamics. 1999; 22(1): 103-114.
15. Sh P, Boukas EK, Agarwal RK. Control of Markovian Jump Discrete-Time Systems with Norm-Bounded Uncertainty and Unknown Delay. IEEE Transactions on Automatic Control. 1999; 44(11): 2139-2144.
16. Agarwal RK, Halt DW. A Compact High-Order Unstructured Grids Method for the Solution of Euler Equations. International Journal of Numerical Methods in Fluids. 1999; 31: 121-147. doi: 10.1002/(SICI)1097-0363(19990915)31:1<121::AID-FLD959>3.0.CO;2-S
17. Agarwal RK, Augustinus J. A Characteristics Based Box Scheme for Compressible Eight-Wave Structure Ideal MHD Equations. Computational Fluid Dynamics Journal. 1999; 8(2): 170-177.
18. Al-Khawaja MJ, Agarwal RK, Gardner RA. Numerical Study of Magneto-Fluid-Mechanic Combined Free-and-Forced Convection Heat Transfer. International Journal of Heat Mass Transfer. 1999; 42: 467-475. doi: 10.1016/S0017-9310(98)00172-0
19. Balakrishnan R, Agarwal RK, Yun KY. BGK-Burnett Equations for Flows in the Continuum-Transition Regime. Journal of Thermophysics and Heat Transfer. 1999; 397-410. doi: 10.2514/2.6464
20. Sh P, Shue SP, Shi Y, Agarwal RK. Controller Design for Bilinear Systems with Parametric Uncertainties. Mathematical Problems in Engineering. 1999; 4: 505-528. doi: http://dx.doi.org/10.1155/S1024123X98000945
21. Agarwal RK. Parallel Implementation of a Compact High Order Maxwell Solver, in Parallel Computational Fluid Dynamics. Lin CA, Ecer A, Satofuka N, Fox P, Periaux J, ed. North Holland, NY. 1999; 327-336.
22. Fernandez JE, Agarwal RK, Landwehr H, Poonawala M, Garcia D. The Effects of Arm Suorts During Light Assembly and Computer Work Tasks. International Journal of Industrial Ergonomics. 1999; 24(5): 493-502. doi: 10.1016/S0169-8141(98)00076-6
23. Sh P, Boukas EK, Agarwal RK. Kalman Filtering for Continuous-Time Uncertain Systems with Markovian Jumping Parameters. IEEE Transactions on Automatic Control. 1999; 44(8): 1592-1597. doi: 10.1109/9.780431
24. Agarwal RK. A Unified CFD-Based Aroach to a Variety of Problems in Computational Physics, in Barriers and Challenges in Computational Fluid Dynamics. In: Venkatakrishnan V, Salas MD, Chakravarthy SR, ed. Kluwer Academic, Boston. 1998; 259-282.
25. Agarwal RK, A Primitive Variable Finite-ume Method for Incompressible Viscous Magnetohydrodynamic Flows. International Journal of Computer Alications in Technology. 1998; 11(3/4/5): 170-176.
26. Yun KY, Agarwal RK, Balakrishnan R. Augmented Burnett and Bhatnagar-Gross-Krook-Burnett Equations for Hypersonic Flow. Journal of Thermophysics and Heat Transfer. 1998; 12(3): 328-335. doi: 10.2514/2.6365
27. Sh P, Shue SP, Agarwal RK. Robust Disturbance Attenuation with Stability for a Class of Uncertain Singularly Perturbed Systems. International Journal of Control. 1998; 70: 873-891. doi: 10.1080/002071798222019
28. Farris BA, Landwehr H, Fernandez JE, Agarwal RK. Evaluation of the Placement of Mouse Pads. Advances in Occupational Ergonomics and Safety. 1998; 487-490.
29. Garcia DT, Wong S, Fernandez JE, Agarwal RK. Effect of Arm Suort on Muscle Activity. Advances in Occupational Ergonomics and Safety. 1998; 483-486.
30. Balakrishnan P, Agarwal RK. Numerical Simulation of BGK-Burnett Equations for Hypersonic Flows. Journal of Thermophysics and Heat Transfer. 1997; 11: 391-399.
31. Balakrishnan P, Agarwal RK. Higher-Order Distribution Functions, BGK-Burnett Equations and Boltzmann H Theorem, n CFD Review; 2. In: Hafez M, Oshima K, eds. 1997; 794-832.
32. Agarwal RK. A Compact Fourth-Order Finite-ume Time-Domain/Frequency Domain Method for Electromagnetic Scattering, in Aroximations and Numerical Methods for the Solution of Maxwell Equations. In: El Dabaghi F, Morgan K, Parrott AK, Periaux J, ed. Clarendon Press, Oxford. 1997; 33-68.
33. Balakrishnan R, Agarwal RK. Entropy Consistent Formulation and Numerical Simulation of the BGK-Burnett Equations Using a Kinetic Wave/Particle Flux Splitting Algorithm, in Proceedings of the Fifteenth International Conference on Numerical Methods in Fluid Dynamics, Lecture Notes in Physics. In: Kutler P, Flores J, Chattot JJ, ed. Springer-Verlag. 1997; 480-485.
34. Farris BA, Fernandez JE, Agarwal RK. The Effect of Wrist Posture on the Force Exerted by Individual Fingers. Advances in Occupational Ergonomics and Safety. 1997; 301-304.
35. Devlin KM, Fernandez JE, Agarwal RK. The Effect of Grip Span on the Force Exerted by Individual Fingers. Advances in Occupational Ergonomics and Safety. 1997; 305-308.
36. Garcia DT, Fernandez JE, Agarwal RK. Implementation of Arm Suorts as an Aid to Office Computer Tasks. Advances in Occupational Ergonomics and Safety. 1997; 429-432.
37. Farris BA, Fernandez JE, Agarwal RK, Sutherland JA. Evaluation of Mouse Pad Placement During Typical Computer Tasks. Advances in Industrial Engineering Alications and Practice II. In: Chen JG, Mital A, eds. 1997; 349-354.
38. Devlin KM, Fernandez JE, Agarwal RK, Pendleton MK. The Effect of Grip Span and Wrist Posture on the Force Exerted by the Middle and Index Fingers Exclusively. Advances in Industrial Engineering Alications and Practice II. In: Chen JG, Mital A, ed. 1997; 393-398.
39. Agarwal RK. Advanced Computational Technology for Product Design. In Solving Large Scale Problems in Mechanics: Parallel and Distributed Computer Alications. In: Papadrakakis M, Wiley J, ed. 1996; 399-433. 40. Agarwal RK. Computational Fluid Dynamics. Engineering Handbook, CRC Press. 1996.
41. Agarwal RK. An Overview of Large Scale Aerospace Alications of CFD, in Solution Techniques for Large CFD Problems. In: Habashi WG, Wiley J, ed. 1995; 375-390.
42. Al-Khawaja MJ, Gardner RA, Agarwal RK. Numerical Study of Magneto-Fluid-Mechanics Forced Convection Pipe Flow. Engineering Journal of Qatar University. 1994; 7: 115-134.

Amit Modgil, PhD

Department of Neuroscience
School of Medicine
Tufts University
Boston, MA, USA

BiographyResearch InterestScientific ActivitiesPublications

Dr. Modgil is a Postdoctoral fellow in the department of Neuroscience at Tufts university- School of medicine, Boston, MA. He has completed his doctoral training (PhD) in neurogenic hypertension from North Dakota state university, Fargo, ND. His doctoral research was focused on central blood pressure regulation and pathogenesis of hypertension to identify novel targets for the treatment of cardiovascular diseases. He has also worked at GSK, where he was part of the discovery and development of ion channel-targeting therapeutics team for the treatment of respiratory diseases. Dr. Modgil is a trained pharmacologist & electro physiologist with research experience in academia and industry. He has broad scientific knowledge in ion channel pharmacology and physiology. Utilizing electrophysiological techniques, his ongoing work is to examine the properties of recombinant and native extra synaptic GABAA receptors with special emphasis on α4 and δ subunits and their preferential targeting by endogenous and clinically relevant agents. His project is focused on fragile X syndrome in regards to altered activity of extra synaptic γ-amino butyric acid type A (GABAA) receptors that mediate tonic inhibition and impacts action potential firing frequency and are particularly sensitive to general anaesthetics and neurosteroids.

His research interests include: Extrasynaptic GABAA receptors mediate tonic inhibition and play an important role in regulating neuronal excitability. His research goals are focused on the development of novel therapeutic targets for the treatment of neurological disorders involving aberrant tonic inhibition. Extrasynaptic GABAA receptors may be the potential candidates for therapeutic treatment in range of neurological disorders such as fragile X mental retardation, γ-hydroxybutyric acid (GHB)-uria, stress, disorders associated with menstrual cycle and puberty, and idiopathic generalized and temporal lobe epilepsies. Utilizing electrophysiological techniques, his ongoing work is to examine the properties of recombinant and native extrasynaptic GABAA receptors with special emphasis on α4 and δ subunits and their preferential targeting by endogenous and clinically relevant agents. In particular, he is working on fragile X syndrome in regards to altered activity of extrasynaptic γ-aminobutyric acid type A (GABAA) receptors that mediate tonic inhibition and impacts action potential firing frequency and are particularly sensitive to general anaesthetics and neurosteroids.

HONORS AND AWARDS


• The honor society of Phi Kappa Phi: Member
• Oral presentation selected at 24th Neuropharmacology meeting at Arlington, VA, USA November 2014
• Awarded with 2011-2012 Darryle and Clare Schoepp Graduate Research Scholarship by the NDSU College Scholarship Recognition Committee
• Best Poster Presentation: 2nd prize at 42nd annual Pharmaceutics Graduate Student Research Meeting (PGSRM) 2010 in Columbus, Ohio
• Travel Award: AstraZeneca Travel ship award 2010 for American Association of Pharmaceutical Scientists (AAPS) 2010 national meeting at New Orleans
• Travel Award: The Joseph Buckley Fund from American Society for Pharmacology & Experimental Therapeutics (ASPET) to attend National meeting of EXPERIMENTAL BIOLOGY 2011 at Washington DC
• Travel Award: Non-Faculty Travel Award from Research, Creative Activities & Technology Transfer (RCATT) to attend National meeting of EXPERIMENTAL BIOLOGY 2011 at Washington DC
• Awarded Junior Research Scholarship by University Grant Commission (UGC) to pursue Masters Program in Medicinal Chemistry from Panjab University
• Awarded Masters Paramhansa Yogananda Scholarship in March 2004


MEMBERSHIP IN SCIENTIFIC AND PROFESSIONAL SOCIETIES


• American Physiological Society (APS) (2010-Present)
• American Association of Pharmaceutical Scientists (AAPS) (2007-Present)
• American Society for Pharmacology and Experimental Therapeutics (ASPET) (2010-Present)
• Society for Experimental Biology and Medicine (SEBM) (2010-Present)
• Member of Indian Pharmaceutical Association (IPA) (2003-2006)

Manuscripts


1. Abramian AM, Comenencia-Ortiz E, Modgil A, et al. Neurosteroids promote phosphorylation and membrane insertion of extrasynaptic GABAAreceptor. Proc Natl Acad Sci USA. 2014; 111(19): 7132-7137. doi: 10.1073/pnas.1403285111
2. Modgil A, O Rourke S, Sun C, et al. Angiotensin(1-7) Attenuates the Chronotropic Response to Angiotensin II via Stimulation of PTEN in the SHR Neurons. Am J Physiol Heart Circ Physiol. 2012; 302(5): H1116-H1122. doi: 10.1152/ajpheart.00832.2011
3. Modgil A, O Rourke S, Sun C. Apelin-13 Inhibits large-conductance Ca+2-activated K+ (BKca) channels in Vascular Smooth Muscle (VSM) cells via a PI3-kinase dependent Mechanism. PLOS ONE. 2013; 8(12): e83051. doi: 10.1371/journal.pone.0083051
4. Yao F, Modgil A, Zhang Q, et al. Pressor Effect of Apelin-13 in the Rostral Ventrolateral Medulla: Role of NAD(P)H Oxidase derived Superoxide. J Pharmacol Exp Ther. 2011; 336(2): 372-380. doi: 10.1124/jpet.110.174102
5. Sharma G, Modgil A, Sun C, Singh J. Grafting of cell-penetrating peptide to receptor-targeted liposomes improves their transfection efficiency and transport across blood-brain barrier model. J Pharm Sci. 2012; 101(7): 2468-2478. doi: 10.1002/jps.23152
6. Hevus I, Modgil A, Daniels J, et al. Invertible Micellar Polymer Assemblies for Delivery of Poorly Water-Soluble Drugs. Biomacromolecules. 2012; 13(8): 2537-2545. doi: 10.1021/bm3007924
7. Sharma G, Modgil A, Layek B, et al. Cell Penetrating Peptide Tethered Bi-ligand Liposomes for Delivery to Brain in vivo: Biodistribution and Transfection. Journal of controlled release. 2013; 167(1): 1-10. doi: 10.1016/j.jconrel.2013.01.016
8. Sharma G, Modgil A, Singh J, et al. Influence of Short-Chain Cell-Penetrating Peptides on Transport of Doxorubicin Encapsulating Receptor-Targeted Liposomes Across Brain Endothelial Barrier. Pharm Res. 2013 31(5): 1194-1209. doi: 10.1007/s11095-013-1242-x
9. Shukla P, Modgil A, O Rourke ST. Maternal Nutrient Restriction During Pregnancy Impairs an Endothelium-Derived Hyperpolarizing Factor-Like Pathway in Sheep Fetal Coronary Arteries. Am J Physiol Heart Circ Physiol. 2014; 307(2): H134-H142. doi: 10.1152/ajpheart.00595.2013

Dominique Durand, PhD

EL Lindseth Professor of Biomedical Engineering
Departments of Biomedical Engineering, Physiology, Biophysics and Neurosciences
Director, Neural Engineering Center
Editor in chief, Journal of Neural Engineering
Case Western Reserve University
Cleveland, OH, 44106, USA

BiographyResearch InterestScientific ActivitiesPublications

Dr. Durand is the EL. Linsedth Professor of Biomedical Engineering Neurosciences, Physiology and Biophysics and Director of the Neural Engineering Center at Case Western Reserve University in Cleveland, Ohio. He received an engineering degree from Ecole Nationale Superieure dElectronique, Hydrolique, Informatique et Automatique de Toulouse, France in 1973. In 1974, he received a M.S. degree in Biomedical Engineering from Case Reserve University in Cleveland OH., worked several years at the Addiction Research Foundation of Toronto, Canada and in 1982 received a Ph.D. in Electrical Engineering from the University of Toronto in the Institute of Biomedical Engineering. He received an NSF Young Investigator Presidential Award as well as the Diekhoff and Wittke awards for graduate and undergraduate teaching and the Mortar board top-prof awards at Case Western Reserve University. He is an IEEE Fellow and also Fellow of the American Institute for Medical and Biomedical Engineering and Fellow of the Institute of Physics. He serves on five editorial boards of peer-reviewed scientific journals and he is the editor-in-chief and founding editor of the Journal of Neural Engineering. His research interests are in neural engineering and include computational neuroscience, neurophysiology and control of epilepsy, non-linear dynamics of neural systems, neural prostheses and applied magnetic and electrical field interactions with neural tissue. He has obtained funding for his research from the National Science Foundation, the National Institutes of Health and private foundations. He has published over 100 articles and he has consulted for many biotechnology companies and foundations.

His research interests include: Neural Engineering is a new discipline at the interface between engineering and neuroscience. Neural Engineering research in his laboratory combines computational neuroscience, engineering and electrophysiology to solve problems in the central and peripheral nervous systems.
In the CNS, the mechanisms of synchronization of neuronal activity during epilepsy are investigated using in-vitro brain slice preparations, in-vivo multiple electrode recording, computer models and clinical trials. The interaction between applied currents and neuronal tissue are studied to determine the feasibility of controlling seizures in patients with epilepsy. In the peripheral nervous system, novel nerve electrodes are being developed capable of stimulating and recording neuronal activity selectively. This neural interfacing methodology is applied to the hypoglossal nerve to restore patency in the airways in patients with obstructive sleep apnea and to design neural prostheses for patients with spinal cord injury and stroke. Computer simulations of both neurons and volume conductors are used in conjunction with the experiments for the quantitative analysis of neural systems and to design new electrodes for interfacing with the nervous system.

AWARDS


• Young Investigator Award, Whitaker Foundation, (1983-1986)
• National Science Foundation Presidential Young Investigator Award, Cleveland, (1985)
• Carl F. Wittke Award for Distinguished Undergraduate Teaching, CWRU, (1991)
• Visiting Professor for a Week, Institute of Biomedical Engineering, University of Toronto, (1993)
• John S. Diekhoff Award for Outstanding Graduate Teaching, CWRU, Cleveland, (1994)
• Fellow of the American Institute for Medical and Biomedical Engineering, (1998)
• Editor-in-chief and founder, Journal of Neural Engineering, (2003)
• Fellow of the Institute of Physics, (2004)
• IEEE, Senior Member, (2006)
• IEEE Fellow, (2010)
• Elected North American Representative to the IEEE-EMBS, (2010 )
• Eminent Scientist of the year, International Research Promotion Council, (2010)
• Graduate teaching award, School of Engineering, (2012)
• Innovation Research Award, School of Engineering, 2012)
• Top 25 STEM professor in OHIO, (2013)
• University Distinguished Research Award, CWRU, (2014)

1. Katona PG, Durand D, Stern K. Microprocessor-controlled memory for cardio-pulmonary monitoring of high risk infants. IEEE Transactions on Biomedical Engineering. 1977; 24: 536-538.
2. Zilm D, Durand D, Kaplan H. A microprocessor-controlled clinical tremometer. Behavior Research Methods and Instrumentation. 1978; 10: 177-181.
3. Kaplan H, Durand D. A shared-memory approach to microprocessor program development. Behaviour Research Methods and Instrumentation. 1979; 11: 311-313.
4. Carlen PL, Durand D. Modeling the postsynaptic location and magnitude of tonic conductance changes resulting from neurotransmitters or drugs. Neuroscience. 1981; 6: 839-846.
5. Durand D, Corrigall W, Kujtan P, Carlen PL. Effect of low-dose ethanol on CA1 hippocampal neurons in-vitro. Canadian Journal of Physiology and Pharmacology. 1981; 59: 972-984.
6. Carlen PL, Gurevich N, Durand D. Low-dose ethanol augments calcium-mediated mechanisms measured intracellularly in hippocampal neurons. Science. 1982; 215: 306-309.
7. Durand D, Carlen PL, Gurevich N, Ho A, Kunov H. Measurement of the passive electrotonic parameters of granule cells in the rat hippocampus using HRP staining and short current pulses. Journal of Neurophysiology. 1983; 50: 1080-1096.
8. Durand D, Carlen PL. Decreased neuronal inhibition after long-term administration of ethanol in-vitro. Science. 1984; 224: 1349-1361.
9. Durand D, Carlen PL. Impairment of long-term potentiation in rat hippocampus following chronic ethanol treatment. Brain Research. 1984; 308: 325-332.
10. Durand D. The shunt cable model for nerve cells. Biophysical Journal. 1984; 46: 645-653.
11. Durand D, Carlen PL. Electrotonic parameters of neurons following chronic ethanol treatment. Journal of Neurophysiology. 1985; 54: 807-817.
12. Durand D. Electrical stimulation can inhibit synchronized neuronal activity. Brain Research. 1986; 382: 139-144.
13. DiMarco TF, Altose MD, Cropp A, Durand D. Activation of Respiration Intercostal Muscles by Electrical Stimulation. American Reviews of Respiration Disease. 1987; 136: 1385-1390. doi: 10.1164/ajrccm/136.6.1385
14. Durand D, Saint-Cyr JA, Gurevich N, Carlen PL. Ethanol-induced dendritic alterations in hippocampal granule cells. Brain Research. 1989; 477: 373-377.
15. Lefkowitz M, Durand D, Smith G, Silver G. The electrical properties of axons within the Probst neuromas of accallosal animals and callosi that have reformed upon glial-coated polymer implants. Experimental Neurology. 1991; 113: 306-314.
16. Ferguson AS, Durand D. Magnetic Fields of Current Monopoles in Special Volume Conductors. IEEE Transactions on Magnetics. 1991; 27: 758-767.
17. Yuen G, Durand D. Reconstruction of hippocampal granule cell electrophysiology by computer simulation. Neuroscience. 1991; 41: 411-424.
18. Kayyali H, Durand D. Effects of applied currents in epileptiform bursts in-vitro. Exp. Neurol. 1991; 113: 249-254.
19. Nakagawa M, Durand D. Suppression of Spontaneous Epileptiform Activity with Applied Currents. Brain Research. 1991; 567: 241-247.
20. Yuen G, Patil M, Durand D. Effects of Ethanol on the excitability of hippocampal granule cells. Brain Research. 1991; 563: 325-320.
21. Ferguson AS, Durand D. A theory of the magnetic field from current monopoles. J. of Applied Physics. 1992; 77: 3107-3113.
22. Durand D, Ferguson AS, Dalbasti T. Effect of Surface Boundary on Neuronal Magnetic Stimulation. IEEE Transactions on Biomedical Engineering. 1992; 39: 58-64. doi: 10.1109/10.108128
23. Ali Hassan W, Saidel GM, Durand D. Estimation of Electrotonic Parameters of Neurons using an Inverse Fourier Transform Technique. IEEE Transactions on Biomedical Engineering. 1992; 39: 493-501.
24. Warman E, Grill WM, Durand D. Modelling the effect of electric fields on nerve fibers: determination of excitation threshold. IEEE Transactions on Biomedical Engineering. 1992; 39: 1244-1254.
25. Nagarajan S, Durand D. Effects of induced electric fields on finite neuronal structures: a simulation study. IEEE Transactions on Biomedical Engineering. 1993; 40: 1175-1188. doi: 10.1109/10.245636
26. Tawfik B, Durand D. Non-Linear Parameter estimation by linear association: application to a 5-parameter passive neuron model. IEEE Transactions on Biomedical Engineering. 1994; 41: 461-469. doi: 10.1109/10.293221
27. Warman EN, Durand DM, Yuen GLF. Reconstruction of Hippocampal CA1 pyramidal cell electrophysiology by computer simulation. J. of Neurophysiology. 1994; 71: 2033-2045.
28. Durand DM, Warman WN. Desynchronization of neuronal activity by extracellular current pulses in the hippocampus in-vitro. J. Physiology (London). 1994; 480(3): 527-537.
29. Nagarajan S, Durand DM, Roth BJ, Wijisesinghe RS. Magnetic stimulation of axons in a nerve bundle: effects of current redistribution in the bundle. Annals of Biomedical Engineering. 1995; 23: 116-126. doi: 10.1007/BF02368319
30. Nagarajan S, Durand DM. Analysis of Magnetic stimulation of a concentric axon in a nerve bundle. IEEE Transactions on Biomedical Engineering. 1995; 42: 926-933. doi: 10.1109/10.412659
31. Nagarajan S, Durand DM. A generalized cable equation for magnetic stimulation. IEEE Transactions on Biomedical Engineering. 1996; 43: 304-312. doi: 10.1109/10.486288
32. Lin JC, Durand DM. Weighted linear associative memory approach to non-linear parameter estimation. Journal of Optimization Theory and Applications. 1996; 90: 139-159. doi: 10.1007/BF02192250
33. Nagarajan S, Durand DM, Hsuing-Hsu K. Mapping Location of excitation during magnetic stimulation: Effect of coil position. Annals of Biomedical Engineering. 1997; 25: 112-125.
34. Durand DM, Lin JC. Theoretical Study of Magnetic Fields of Current monopoles in special volume conductors. IEEE Transactions on Biomedical Engineering. 1997; 44: 177-187. doi: 10.1109/10.552247
35. Tyler D, Durand DM. Slowly penetrating interfascicular electrode for electrical stimulation of nerves. IEEE Transactions on Rehabilitation. 1997; 5: 51-61.
36. Tawfik B, Durand DM. Parameter estimation by reduced order linear associative memory. (ROLAM). IEEE Transactions on Biomedical Engineering. 1997; 44: 297-305.
37. Sahin M, Haxhiu M, Durand DM. The spiral Nerve Cuff for recording respiratory output. J of Applied Physiology. 1997; 83: 317-322.
38. Lin JC, Durand DM. Non-linear parameter estimation by weighted linear associative memory with non-zero interception. IEEE Transactions on Systems, Man and Cybernetics. 1997; 27: 692-702. doi: 10.1109/3477.604114
39. Lyubkin M, Durand DM, Haxhiu MA. Short episodes of hypoxia inhibit the generation of LTP and disrupt pre-existing levels of synaptic potentiation. J. of Neurophysiology. 1997; 78: 2475-2482.
40. Carbunaru R, Durand DM. Axonal stimulation under MRI magnetic field z-gradients. Magnetic resonance in Medicine. 1997; 38: 750-758. doi: 10.1002/mrm.1910380511
41. Lin J, Durand DM. Magnetic Field of current monopoles in prolate and oblate spheroid volume conductors. IEEE Transactions in Magnetics. 1998; 34: 2177-2184.
42. Klemic KG, Durand DM, Jones SW. Activation kinetics of the delayed rectifier potassium current of bullfrog sympathetic neurons. J. Neurophys. 1998; 79: 2345-2357.
43. Sahin M, Durand DM. Improved nerve cuff electrode recordings with subthreshold anodic currents. IEEE Transactions on Biomedical Engineering. 1998; 45: 1044-1050. doi: 10.1109/10.704873
44. Maccabee PJ, Nagarajan SS, Amassian VE, et al. Influence of pulse sequency, polarity and amplitude in magnetic stimulation of human and porcine peruipheral nerve. J. of Physiology (London). 1998; 513(2): 571-585. doi: 10.1111/j.1469-7793.1998.571bb.x
45. Warren RJ, Durand DM. Effects of applied currents on spontaneous epileptiform activity induced by low-calcium in the rat hippocampus. Brain Research. 1998; 806: 186-195.
46. Bertrand CA, Durand DM, Saidel G, Laboisse C, Hopfer U. A system for dynamic measurement of membrane capacitance in epithelial monolayers. Biophysical Journal. 1999; 75: 2743-2756. doi: 10.1016/S0006-3495(98)77718-5
47. Qi H, Tyler DJ, Durand DM. Neurofuzzy adaptive controlling of selective stimulation for FES: a case study. IEEE Transactions on Rehabilitation Engineering. 1999; 7: 183-192.
48. Patil MM, Durand DM, Lamana JC, Whittingham TS, Haxhiu MA. Effects of oxygen deprivation of parapyramidal neurons of the ventrolateral medulla. Respiration Physiology. 1999; 115: 11-22.
49. Bikson M, Baraban S, Durand DM. Modulation of burst activity, width, and amplitude in the zero-calcium model of epileptiform activity. Journal of Neurophysiology. 1999; 82: 2262-2270.
50. Sahin M, Durand DM, Haxhiu M. Chronic recordings of hypoglossal nerve activity in a dog model of upper airway obstruction. J. Appl. Physiol. 1999; 87(6): 2297-2206. 51. Shuai JW, Durand DM. Phase Synchronization of two coupled chaotic neurons. Physics Letters A. 1999; 264: 289-297.
52. Cuocco F, Durand DM. Measurement of external pressures generated by nerve cuff electrodes. IEEE Transactions on Rehabilitation Engineering. 2000; 8: 35-41.
53. Hsu KH, Durand DM. Prediction of neural excitation during magnetic stimulation using passive cable models. IEEE transactions on Biomedical Engineering. 2000; 47: 463-471. doi: 10.1109/10.828146
54. Shuai JW, Durand DM. Strange non-chaotic attractors in-low frequency quasi-periodically driven systems. International Journal of Bifurcation and Chaos. 2000; 10: 2269-2276. doi: 10.1142/S0218127400001444
55. Stacey B, Durand DM. Stochastic resonance can enhance synaptic transmission. J. of Neurophysiology. 2000; 83: 1394-1402.
56. Sahin M, Durand DM, Haxhiu MA. Closed-loop stimulations of the hypoglossal nerve using its spontaneous activity as the feedback signal. IEEE Transactions in Rehabilitation Engineering. 2000; 47: 919-925.
57. Gha R, Bikson M, Durand DM. Effects of applied electric fields on low calcium epileptiform activity in the CA1 region rat hippocampal slices. J. of Neurophysiology. 2000; 84: 274-280.
58. Perez-Orive J, Durand DM. Modelling study of peripheral nerve recording selectivity. IEEE Transactions on Rehabilitation Engineering. 2000; 8: 320-329. doi: 10.1109/86.867874
59. Bikson M, Lian J, Hahn P, Stacy W, Sciortino C, Durand DM. Suppression of epileptiform activity with high frequency sinusoidal fields . J. Physiology, (London). 2001; 531: 181-191. doi: 10.1111/j.1469-7793.2001.0181j.x
60. Choi AQ, Cavanaugh J, Durand DM. Selectivity of multiple contact nerve electrode: a simulation analysis. IEEE transactions on BME. 2001; 48: 165-172.
61. Lian J, Shuai JW, Durand DM. Non-linear dynamic properties of low calcium induced epileptiform activity. Brain Research. 2001; 890: 246-254.
62. Carbunaru R, Durand DM. Toroidal coil for transcutaneous magnetic stimulation of nerves. IEEE Transactions on Biomedical Engineering. 2001; 48: 434-442. doi: 10.1109/10.915709
63. Yobas L, Huff M, Lisy F, Durand DM. A novel bulk-micromachined electrostatic microvalve with a curved-compliant structure applicable for a pneumatic tactile display. J of Microelectromechanical systems. 2001; 10: 187-196.
64. Hahn PJ, Durand DM. Bistability in Neural Dynamics and the effects of increased extracellular potassium. J. Comput Neurosci. 2001; 11(1): 5-18.
65. Shuai JW, Lian J, Hahn PJ, Durand DM. Positive Lyapunov exponents calculated from time-series of strange nonchaotic attractors. Phys Rev E. 2001; 64: 026220. doi: http://dx.doi.org/10.1103/PhysRevE.64.026220
66. Stacey WC, Durand DM. Synaptic noise improves the detection of sub-threshold signals in the hippocampus. J Neurophysiol. 2001; 86(3): 1104-1112.
67. Hsu KH, Durand DM. A 3D differential coil design for localized magnetic stimulation. IEEE Transactions on Biomedical Engineering. 2001; 48: 1162-1168. doi: 10.1109/10.951519
68. Lian J, Bikson M, Shuai J, Durand DM. Propagation of non-synaptic epileptiform activity across a lesion in rat hippocampal slices. J Physiol. 2001; 537(1): 191-199. doi: 10.1111/j.1469-7793.2001.0191k.x
69. Bikson M, Baraban SC, Durand DM. Conditions sufficient for non-synaptic epileptogenesis in the CA1 region of hippocampal slices. J. Neurophysiology. 2002; 87: 62.
70. Tyler DJ, Durand DM. Functionally Selective Peripheral Nerve electrode: Stimulation with a flat interface nerve electrode. IEEE Transactions on Neural Systems and Rehabilitation. 2002; 10(4): 294-303. doi: 10.1109/TNSRE.2002.806840
71. Stacey W, Durand DM. Noise and coupling affect signal detection and bursting in a simulated physiological neural network. J. of Neurophysiology. 2002; 88(5): 2598-2611. doi: 10.1152/jn.00223.2002
72. Lian J, Bikson M, Sciortino C, Stacey WC, Durand DM. Local Suppression of epileptiform activity be electrical stimulation: an in-vitro study. Journal of Physiology (London). 2003; 1(547): 427-434. doi: 10.1113/jphysiol.2002.033209
73. Leventhal D, Durand DM. Sub fascicular stimulation selectivity with the flat nerve electrode. Annals of Biomedical Engineering. 2003; 6: 643-652. doi: 10.1114/1.1569266
74. Shuai J, Bikson M, Hahn P, Lian J, Durand DM. Ionic mechanisms underlying spontaneous CA1 neuronal firing in C2+-free solutions. Biophysical Journal. 2003; 84: 2099-2111. doi: 10.1016/S0006-3495(03)75017-6
75. Shuai JW, Durand DM. Strange non-chaotic attractors in neural networks, International Journal of Bifurcation and Chaos. 2003; 13: 251-260.
76. Yobas L, Durand DM, Skebe GG, Lisy FJ, Huff MA. A Novel Integrable Microvalve for Refreshable Braille Display System. J of Microelectromechanical Systems. 2003; 12: 252-263. doi: 10.1109/JMEMS.2003.811754
77. Hsu KH, Nagarajan SS, Durand DM. Analysis of the efficiency of magnetic stimulation. IEEE Trans. Biomed. Eng. 2003; 50(11): 1276-1285. doi: 10.1109/TBME.2003.818473
78. Feng Z, Durand DM. Low calcium epileptiform activity in the hippocampus in-vivo. J. of Neurophysiology. 2003; 4: 2253-2260. doi: 10.1152/jn.00241.2003
79. Tyler DJ, Durand DM. Chronic response of the rat sciatic nerve to the flat interface nerve electrode. Annals of Biomedical Engineering. 2003; 31: 633-642.
80. Lertmanorat Z, Durand DM. A novel electrode array for diameter dependant control of axonal excitability. IEEE Transactions on Biomedical Engineering. 2004; 51: 1242-1250. doi: 10.1109/TBME.2004.827347
81. Yoo P, Durand DM. Selective stimulation of the hypoglossal nerve using a multi-contact cuff electrode. Annals of Biomedical Engineering. 2004; 32: 511-519.
82. Lian J, Shuai JW, Durand DM. Control of Phase Synchronization of Neuronal Activity in the Rat Hippocampus. Journal of Neural Engineering. 1: 46-54. doi: 10.1088/1741-2560/1/1/007
83. Leventhal D, Durand DM. Chronic Measurement of the Stimulation Selectivity of the Flat Interface Nerve Electrode. IEEE Transactions on Biomedical Engineering. 2004; 51(9): 1649-1658. doi: 10.1109/TBME.2004.827535
84. Feng Z, Durand D. Suppression of Excitatory Synaptic Transmission Can Facilitate Low-Calcium Epileptiform Activity in the Hippocampus in-vivo. Brain Research. 2004; 24(1030(1)): 57-65.
85. Lertmanorat Z, Durand DM. Extracellular voltage profile for reversing the recruitment order of peripheral nerve stimulation: a simulation study. J. of Neural Engineering. 2004; 1: 202-211. doi: 10.1088/1741-2560/1/4/003
86. Feng Z, Durand DM. Decrease in Synaptic Transmission Can Reverse the Propagation Direction of Epileptiform Activity in Hippocampus in vivo. J. Neurophysiology. 2005; 93: 1158-1164. doi: 10.1152/jn.00593.2004
87. Kumar A, Han Y, DellOsso LF, Durand DM, Leigh RJ. Directional asymmetry during combined saccade-vergence movements. J. Neurophysiology. 2005; 93: 2797-2808. doi: 10.1152/jn.00858.2004
88. Yoo PB, Durand DM. Selective recording of the canine hypoglossal nerve using a multi-contact flat interface nerve electrode. IEEE Transactions on Biomedical Engineering. 2005; 52(8): 1461-1469. doi: 10.1109/TBME.2005.851482
89. Yoo PB, Durand DM. Effects of Selective Hypoglossal Nerve Stimulation on Canine Upper Airway Mechanics. Journal of Applied Physiology. 2005; 99(3): 937-943. doi: 10.1152/japplphysiol.00652.2004
90. Feng Z, Durand DM. Propagation of low-calcium non-synaptic induced epileptiform activity to the contralateral hippocampus in-vivo. Brain Research. 2005; 1055(1-2): 25-35.
91. Huang J, Sahin M, Durand DM. Dilation of the oropharynx via selective stimulation of the hypoglossal nerve. Journal of Neural Engineering. 2005; 2: 73-80. doi: 10.1088/1741-2560/2/4/002
92. Lertmanorat Z, Durand DM. Electrode array for reversing the recruitment order of peripheral nerve stimulation: Experimental studies. Annals of Biomedical Engineering. 2006; 34(1): 152-160. doi: 10.1007/s10439-005-9012-5
93. Park EH, Durand DM. Role of Potassium Lateral Diffusion in Non-synaptic Epilepsy: A Computational Study. Journal of Theoretical Biology. 2006; 238: 666-682.
94. Feng Z, Durand DM. Effects of Potassium Concentration on Firing Patterns of Low-Calcium Epileptiform Activity in Anesthetized Rat Hippocampus - Inducing Persistent Spike Activity. Epilepsia. 2006; 47(4): 727-736. doi: 10.1111/j.1528-1167.2006.00499.x
95. Leventhal DE, Durand DM. Chronic histological effects of the flat interface nerve electrode. Journal of Neural Engineering. 2006; 3: 102-113. doi: 10.1088/1741-2560/3/2/004
96. Jensen A, Durand DM. Suppression of axonal conduction by sinusoidal stimulation in rat Hippocampus. Journal of Neural Engineering. 2007; 4: 1-16. doi: 10.1088/1741-2560/4/2/001
97. Tesfayesus W, Durand DM. Blind Source Separation of Peripheral Nerve Recordings. Journal of Neural Engineering. 2007; 4(3): S157-S167. doi: 10.1088/1741-2560/4/3/S03
98. Durand DM, Tian N, Kile K. Scn2a Sodium Channel Mutation Results in Hyperexcitability in the Hippocampus in vitro. Epilepsia. 2008; 49: 488-499. doi: 10.1111/j.1528-1167.2007.01413.x
99. Park EH, Durand DM. Diffusive coupling and network periodicity: a computational study. Biophysical Journal. 2008; 9: 1126-1137. doi: 10.1529/biophysj.108.129239
100. Park HJ, Durand DM. Motion Control of Musculoskeletal Systems with Redundancy, Biological Cybernetics. Biol Cybern. 2008; 6: 503-516. doi: 10.1007/s00422-008-0258-5
101. Caparso AV, Mansour JM, Durand DM. A nerve cuff electrode for controlled reshaping of nerve geometry. J. of Biomaterial Applications. J Biomater Appl. 2009; 24(3): 247-273. doi: 10.1177/0885328208097426.
102. Wang K, Liu CC, Durand DM. Characterization of Sputtered Iridium Oxide Electrodes on Liquid Crystal Polymer for Electrical Stimulation of Neural Tissue. IEEE Transactions on Biomedical Engineering. 2009; 56(1): 6-14.
103. Lertmanorat Z, Montague FW, Durand DM. A Flat Interface Nerve Electrode With Integrated Multiplexer. IEEE Transactions on Neural Systems and Rehabilitation. 2009; 17(2): 176-182. doi: 10.1109/TNSRE.2008.2009307
104. Jensen A, Durand DM. High Frequency Stimulation can Stimulation Block Axonal Conduction. Experimental Neurology. 2009; 220: 57-70. doi: 10.1016/j.expneurol.2009.07.023
105. Wodlinger B, Durand DM. Localization and recovery of peripheral nerve sources with beamforming algorithms. IEEE Neural Systems and Rehabilitation. 2009; 5: 461-468. doi: 10.1109/TNSRE.2009.2034072
106. Kile KB, Tian N, Durand DM. Low frequency deep brain stimulation decreases seizure activity in a mutation model of epilepsy. Epilepsia. 2010; 51(9): 1745-1753. doi: 10.1111/j.1528-1167.2010.02679.x
107. Mino H, Durand DM. Enhancement of Information Transmission of Sub-threshold Signals Applied to Distal Positions of Dendritic Trees in Hippocampal CA1 Neuron Models with Stochastic Resonance. Biological Cybernetics. 2010; 103: 227-226. doi: 10.1007/s00422-010-0395-5
108. Jahangiri A, Durand DM. Phase Resetting Analysis of High Potassium Epileptiform Activity in CA3 Region of the Rat Hippocampus. International Journal of Neural Systems. 2011; 21: 127-138. doi: 10.1142/S0129065711002705
109. Kibler AB, Durand DM. Orthogonal Wave Propagation of Epileptiform Activity in the Planar Mouse Hippocampus in-vitro. Epilepsia. 2011; 29: 1590-1600. doi: 10.1111/j.1528-1167.2011.03125.x
110. Kawaguchi M, Mino H, Durand DM. Stochastic Resonance Can Enhance Information Transmission in Neural Networks. IEEE Transactions on Biomedical Engineering. 2011; 58: 1950-1958. doi: 10.1109/TBME.2011.2126571
111. Koubeissi MZ, Rashid S, Xu K, Syed TU, Luders H, Durand DM. Transection of CA3 Does Not Affect Memory Performance in Rats Corresponding. Epilepsy and Behavior. 2011; 21: 267-270. doi: 10.1016/j.yebeh.2011.04.006
112. Calvetti D, Wodlinger B, Durand DM, Somersalo E. Hierarchical beamformer and cross- talk reduction in electroneurography. Journal of Neural Engineering. 2011; 056002.
113. Wodlinger B, Durand DM. Selective Recovery of Fascicular Activity in Peripheral Nerves. Journal of Neural Engineering. 2011; 8: 056005. doi: 10.1088/1741-2560/8/5/056002
114. Rashid S, Pho G, Czigler M, Werz MA, Durand DM. Low Frequency Stimulation of Hippocampal Commissures Reduces Seizures in Chronic Rat Model of Temporal Lobe Epilepsy. Epilepsia. 2011; 53(1): 147-156. doi: 10.1111/j.1528-1167.2011.03348.x
115. Kibler AB, Jamieson BG, Durand DM. High Aspect Ratio Microelectrode Array for Mapping Neural Activity in-vitro. Journal of Neuroscience Methods. 2011; 204(2): 296-305. doi: 10.1016/j.jneumeth.2011.11.027
116. Tang D, Durand DM. A tunable support vector machine assembly classifier for epileptic seizure detection. Expert Systems with Applications. 2012; 39(4): 3925-3938. doi: 10.1016/j.eswa.2011.08.088
117. Chiang CC, Lin CK, Ju MS, Durand DM. High-frequency stimulation can suppress globally seizures induced by 4-AP in the rat hippocampus: An acute in vivo study. Brain Stimulation. 2013; 6(2): 180-189.
118. Tang Y, Durand DM. A novel electrical stimulation paradigm for the suppression of epileptiform activity in an in-vivo model of mesial temporal lobe status epilepticus. International Journal of Neural Systems. 2012; 22(3): 1250006. doi: 10.1142/S0129065712500062
119. Lee S, Ryu K, Waldo A, Khrestian C, Durand DM, Sahadevan J. An Algorithm to Measure Beat-to-Beat Cycle Lengths for Assessment of Atrial Electrogram Rate and Regularity during Atrial Fibrillation. Journal of Cardiovascular Electrophysiology. 2013; 24(2): 199-206. doi: 10.1111/jce.12014
120. Lee S, Sahadevan J, Khrestian C, Durand D, Waldo A. High Density Mapping of Atrial Fibrillation During Vagal Nerve Stimulation in the Canine Heart - Restudying the Moe Hypothesis. Journal of Cardiovascular Electrophysiology. 2013; 24(3): 328-335. doi: 10.1111/jce.12032
121. Toprani S, Durand DM. Fiber Tract Stimulation Can Reduce Epileptiform Activity in an in-vitro Bilateral Hippocampal Slice Preparation. Experimental Neurology. 2013; 240: 28-43. doi: 10.1016/j.expneurol.2012.10.022
122. Wodlinger B, Rashid S, Durand DM. Block of Peripheral Pain Response by High Frequency Sinusoidal Stimulation. Neuromodulation: Technology at the Neural Interface. 2013; 16(4): 312-317. doi: 10.1111/ner.12011
123. Feng Z, Zheng X, Yu Y, Durand DM. Functional Disconnection of Axonal Fibers Generated by High Frequency Stimulation in the Hippocampal CA1 Region in-vivo. Brain Research. 2013; 1509: 32-42. doi: 10.1016/j.brainres.2013.02.048.
124. Koubeissi MZ, Kahriman E, Syed TU, Miller J, Durand DM. Low Frequency electrical stimulation of a fiber tract in temporal lobe epilepsy. Ann Neurol. 2013; 23915.
125. Toprani S, Durand DM. Long-lasting hyperpolarization underlies seizure reduction by low frequency deep brain electrical stimulation. J. Physiology (London). 2013; 591(22): 5765-5790. doi: 10.1113/jphysiol.2013.253757
126. Gonzalez-Reyes L, Ladas TP, Chiang CC, Durand DM. TRPV1 antagonist capsazepine suppresses 4-AP-induced epileptiform activity in vitro and electrographic seizures in vivo. Experimental Neurology. 2013; 250: 321-332. doi: 10.1016/j.expneurol.2013.10.010.
127. Wang Y, Toprani S, Tang Y, Vrabec T. Mechanism of Highly Synchronized Bilateral Hippocampal Activity. Experimental Neurology. 2014; 251: 101-111. doi: 10.1016/j.expneurol.2013.11.014
128. Zhang M, Ladas TP, Qiu C, et al. Durand Propagation of epileptiform activity can be independent of synaptic transmission, gap junctions or diffusion and is consistent with electrical field transmission. J Neuroscience. 2014; 34(4): 1409-1419.


REVIEWS, BOOK CHAPTERS AND EDITORIALS


1. Carlen PL, MacCrea DA, Durand D. Dendrites and motoneuronal integration. Handbook of the Spinal Cord. In: Daviddoff RA, ed. 1984; 243-267.
2. Carlen PL, Blaxter TJ, Freedman EB, Durand D. Putative Capacitance Increase in Hippocampal CA1 Cells Following Ethanol Application. Molecular Mechanisms of Anesthetics 3. In: SH Roth, Miller KW, eds. Plenum. 1985; 57-64.
3. Carlen PL, Gurevich N, Durand D, Daires MF, Blaxter TJ, Wu P. Research advances and new psychopharmacological treatments for alcoholism. In: Naranjo CA, Sellers EM, eds. Elsevier Science Publisher. 1985; 11-20.
4. Ferguson AS, Durand D. Magnetic Fields of Current Monopoles. Advances in Biomagnetism. In: Williamson SJ, ed. Plenum Press, New York, 1989; 583-586. 5. Durand DM. Ictal patterns in experimental models of epilepsy. J. of Clinical Neurophysiology. 1993; 10: 281-297.
6. Durand DM. Book Review: Electrical Properties of Mammalian Tissue: An Introduction. Northover, Chapman & Hall, 1992. Annals of Biomedical Engineering. 1993; 21: 1.
7. Tyler DJ, Durand DM. Interfascicular stimulation for selective activation of surface and deep axon populations. IEEE Engineering in Medicine and Biology Magazine. 1994; 13: 575-583.
8. Durand DM. Electrical stimulation of excitable tissue. Handbook of Biomedical Engineering. CRC Press. 1995; 229-251.
9. Durand DM, Tawfik B. Parameter estimation in the presence of biological and external interference. Concepts and techniques in Biological Measurements: Is the medium carrying the message? Polytechnic School of the Editions de Montreal.1997; 55-66.
10. Durand DM. Microelectrodes, Encyclopedia of Electrical and Electronics Engineering. In: JG Webster, ed. John Wiley & Sons Inc. 1998.
11. Durand DM, Bikson M. Suppression and Control of Epileptiform Activity by Electrical Simulation: a Review. Proceedings of the IEEE, Special issue on Neural Engineering; merging engineering and neuroscience. 2001; 1065-1082.
12. Durand DM, Bikson M. Suppression and Control of Epileptiform Activity by Electrical Stimulation: a Review. Brain Stimulation and Epilepsy. In: Luders H, ed. 2002.
13. Durand DM. Electric field effects in hyperexcitable neural tissue: a review. Radiation Protection Dosimetry. 2003; 106(4): 325-331.
14. Durand DM Editorial: Why we need a new journal in neural engineering. J. Neural Eng. 2004; 1(1).
15. Durand DM, Grill WM, Kirsch R. Electrical Stimulation of the Neuromuscular System. Neural Engineering. In: He B, ed. Kluwer/Plenum Publishers. 2005.
16. Durand DM. The present and future. J. Neural Eng. 2006; 3.
17. Durand DM. Neural Engineering: a new discipline for analyzing and interacting with the nervous system. Methods of Information in Medicine. 2007; 46: 142-147.
18. Durand DM. What is Neural Engineering ? Journal of Neural Engineering. 2007; 4. 19. Durand DM. Focusing at the interface. Journal of Neural Engineering. J Neural Eng. 2009; 6(5): 50202.
20. Micera S, Durand DM, Vrs J. Increasing basic understanding of the nervous system to develop more effective neuroengineering applications EEE Trans Biomed Eng.
2009; 2689-2691.
21. Durand DM, Jahangiri A. Singular Parameter Prediction Algorithm for Bistable Systems. Recent Advances and Research Updates. 2010; 11: 163-179.
22. Durand, DM, Wodlinger B, Park HJ. Interfacing with the peripheral nervous system, a FINE approach. In Neural Engineering part 2. In: He B,ed. Kluwer/Plenum Publishers. 2013.
23. Durand DM, Ghovanloo M, Krames E. Time to address the problems at the neural interface. J Neural Eng. 2014; 11(2): 020201.

Wen-Hai Chou, PhD

Assistant Professor
Department of Biological Sciences
School of Biomedical Sciences
Kent State University
41, Cunningham Hall
Kent, Ohio 44242, USA

BiographyResearch InterestScientific ActivitiesPublications

Dr. Chou received his PhD from Department of Molecular Medicine, University of Texas Health Science Center at San Antonio, Texas, USA. He completed his postdoctoral training at UCSF and later promoted as an Assistant Adjunct Professor, Department of Neurology, UCSF. He is now an Assistant Professor, Department of Biological Sciences, School of Biomedical Sciences, Kent State University, Ohio, USA.
His current research interest focuses on the roles of PKC isozymes and lipocalin-2 in Stroke-reperfusion injury using mouse genetics, experimental stroke models, and Chemical-genetics approaches.

His research interests include: Stroke-reperfusion injury, PKC, Signal transduction, Neuroimmune interactions after stroke, Ischemia-induced Neuro degeneration.

HONORS AND AWARDS


• Elected as a Fellow of the American Heart Association (F.A.H.A.) for making major and productive Contributions in cardiovascular basic sciences, (2011)
• Farris Family Innovation Award, Kent State University, Kent, Ohio, (2011)
Certificate of Achievement from University of Texas Health Science Center at San Antonio, Texas, (2001)
• Certificate of Achievement from National Chung-Hsing University, Taichung, Taiwan, (2001)
• First-place poster award at the Annual Graduate Student Association Forum, University of Texas Health Science Center at San Antonio, Texas, (1998)
• Second-place outstanding research award at the Annual Retreat, Institute of Biotechnology, University of Texas Health Science Center at San Antonio, Texas, (1998)
• Travel award for distinguish research from Institute of Biotechnology, University of Texas Health Science Center at San Antonio, Texas, (1997)


OTHER PROFESSIONAL SERVICE


• Member of Society for Neuroscience, (1998-Present)
• Member of American Stroke Association, (2003-Present)
• Member of American Society for Cell Biology, (2008-2009)
• Member of New York Academy of Sciences, (1999- 2008)
• Member of Society of Chinese Bio scientists in America, (1997-2008)
• Member of Genetics Society of America, (1996-2001)

Refereed Journals


1. Szular J, Sehadova H, Gentile C, et al. Rhodopsin 5 and Rhodopsin 6 mediated clock synchronization in Drosophila melanogaster is independent of retinal Phospholipase C-ß signaling. Journal of Biological Rhythms. 2012; 27(1): 25-36. doi: 10.1177/0748730411431673
2. Chiang T, Messing RO, Chou WH. Mouse model of middle cerebral artery occlusion. Journal of Visualized Experiments. 2011; 48. doi: 10.3791/2761
3. Chou WH, Wang D, McMahon T, et al. GABAA receptor trafficking is regulated by PKC epsilon and the Nethylmaleimide- sensitive factor. Journal of Neuroscience. 2010; 30(42), 13955-13965. doi: 10.1523/JNEUROSCI.0270-10.2010
4. Birkholz DA, Chou WH, Phistry M, Britt SG. Disruption of photoreceptor patterning in the Drosophila Scutoid mutant. Fly. 2009; 3(4): 253-262.
5. Birkholz DA, Chou WH, Phistry M, Britt SG. rhomboid is essential for the differentiation of blue and green sensitive R8 photoreceptor cells in Drosophila. Journal of Neuroscience. 2009; 29(9): 2666-2675. doi: 10.1523/JNEUROSCI.5988-08.2009
6. Chou WH, Messing RO. Hypertensive encephalopathy and the blood-brain barrier: Is deltaPKC a gatekeeper?. Journal of Clinical Investigation. 2008; 118(1): 17-20.
7. Lesscher HMB, McMahon T, Lasek AW, et al. Amygdala PKC epsilon regulates corticotropin-releasing factor and anxietylike behavior. Genes, Brain and Behavior. 2008; 7(3): 323-333.
8. Qi ZH , Song M, Wallace MJ, et al. Protein kinase C epsilon regulates GABAA receptor sensitivity to ethanol and benzodiazepines through phosphorylation of γ2 subunits. Journal of Biological Chemistry. 2007; 282(45): 33052-33063. doi: 10.1074/jbc.M707233200
9. Allen JJ, Li M, Brinkworth CS, et al. A semi-synthetic epitope for kinase substrates. Nature Methods. 2007; 4(6): 511-516. doi: 10.1038/nmeth1048
10. Wallace MJ, Newton PM Oyasu M, et al. Acute functional tolerance to ethanol mediated by Protein Kinase C epsilon. Neur psycho pharmacology. 2007; 32(1): 127-136.
11. Chou WH, Messing,RO. Protein kinase C isozymes in stroke. Trends in Cardiovascular Medicine. 2005; 15(2): 47-51.
12. Chou WH, Cho DS, Zhang H, et al. Neutrophil protein kinase C delta as a mediator of strokereperfusion injury. Journal of Clinical Investigation. 2004; 114(1): 49-56.
13. Knox BE, Salcedo E, Mathiesz K, et al. Heterologous Expression of Limulus Rhodopsin. Journal of Biological Chemistry. 2003; 278(42): 40493-40502.
14. Salcedo E, Huber A, Heinrich S, et al. Blue- and green-sensitive visual pigments of Drosophila: Ectopic expression and physiological characterization of the R8 photoreceptor cell-specific Rh5 and Rh6 rhodopsins. Journal of Neuro science. 1999; 19(24): 10716-10726.
15. Chou WH, Huber A, Bentrop J, et al. Patterning of the R7 and R8 photoreceptor cells: Evidence for induced and default cell-fate specification. Development. 1999; 126(4): 607-616.
16. Chang KH, Chen Y Chen TT, et al. A thyroid hormone receptor coactivator negatively regulated by the retinoblastoma protein. Proceedings of the National Academy of Sciences. 1997; 94(17): 9040-9045.
17. Chou WH, Hall KJ, Wilson DB, et al. Identification of a novel Drosophila opsin reveals specific patterning of the R7 and R8 photoreceptor cells. Neuron. 1996; 17(6): 1101-1115.
18. Chou WH, Wang G, Kumar V, Weng YC. Lipocalin-2 in Stroke. Neuro Open J. 2015; 2(1): 38-41. doi: 10.17140/NOJ-2-109

Yuzhi Chen, PhD

Principal Investigator
Department of Geriatrics
Assistant Professor
Department of Neurobiology and Developmental Sciences
University of Arkansas for Medical Sciences
Little Rock, AR 72205, USA

BiographyResearch InterestScientific ActivitiesPublications

Dr. Chen earned a Ph.D. from the University of Massachusetts Amherst in the fields of virology and neurobiology. She obtained postdoctoral training from Harvard University Medical School with a focus on the molecular biology of Alzheimer’s disease. Dr. Chen is a pioneer in elucidating the function of the neddylation pathway by establishing the cellular basis of inhibiting the nedd8 activating enzyme for cancer treatment. Dr. Chen’s current research is centered on elucidating the function of neddylation pathway in the central nervous system.

Her research interests include: Biological functions of Alzheimers disease-related genes such as APP and Presenilin, neddylation and ubiquitination in neuro degenerative diseases, treatment of Alzheimers disease, and neural stem cell biology.

• 2002-2003 Phyllis and Jerome Lyle Rappaport Mental Research Scholar Award
• 2003-2006 Recipient of Inglewood Scholar Award for Alzheimer’s Research
• 2002-2004 Principal Investigator for American Health Assistance Foundation Pilot Study
• 2010-2015 Principal Investigator of NIH/NIA RO1 grant entitled APP and Ubiquitination
• 2015 July Track chairman for the “CNS Drug Discovery & Therapy” track at the Drug Discovery & Therapy World Congress 2015 (July 22nd-25th, 2015, Boston)

1. Anderson HA, Chen Y, Norkin LC. Bound simian virus 40 translocates to caveolin-enriched membrane domains and its entry is inhibited by drugs that selectively disrupt caveolae. Mol Biol Cell. 1996; 7: 1825-1834. doi: 10.1091/mbc.7.11.1825
2. Anderson HA, Chen Y, Norkin LC. MHC class I molecules are enriched in caveolin-rich fraction but does not mediate SV40 internalization. J Gen Virol. 1998; 79: 1469-1477.
3. Chen Y, Norkin LC. Extracellular simian virus 40 transmits a signal into preformed empty caveolae. Exp Cell Res. 1999; 246: 83-90. doi: 10.1006/excr.1998.4301
4. Izumi KM, McFarland EC, Riley EA, Rizzo D, Chen Y, Kieff E. The residues between the two transformation effector sites of Epstein-Barr virus latent membrane protein 1 are not critical for B-lymphocyte growth transformation. J Virol. 1999; 12: 9908-9916.
5. Chen Y, McPhie DL, Hirschberg J, Neve RL. The amyloid precursor protein-binding protein APP-BP1 drives the cell cycle through the S-M checkpoint and causes apoptosis in neurons. J Biol Chem. 2000; 275: 8929-8935. doi: 10.1074/jbc.275.12.8929
6. Neve RL, McPhie DL, Chen Y. Alzheimers disease: a dysfunction of the amyloid precursor protein. Brain Res. 2000; 886: 54-66. doi: 10.1016/S0006-8993(00)02869-9
7. Neve RL, McPhie DL, Chen Y. Alzheimers disease: a dysfunction of a signaling pathway mediated by the amyloid precursor protein? Biochem Soc Symp. 2001; 67: 37-50.
8. Ohh M, Kim WY, Moslehi JJ, et al. An intact NEDD8 pathway is required for Cullin-dependent ubiquitylation in mammalian cells. EMBO Rep. 2002; 3 (2): 177-182. doi: 10.1093/embo-reports/kvf028
9. Chen Y, Liu W, Naumovski L, Neve RL. ASPP2 inhibits APP-BP1-mediated NEDD8 conjugation to Cullin-1 and decreases APP-BP1-induced cell proliferation and neuronal apoptosis. J Neurochem. 2003; 85: 801-809. doi: 10.1046/j.1471-4159.2003.01727.x
10. McPhie DL, Coopersmith R, Hines-Peralta A, et al. DNA synthesis and neuronal apoptosis caused by familial Alzheimers disease mutants of the amyloid precursor protein are mediated by the p21 activated kinase PAK3. J Neurosci. 2003; 23(17):6914-6927.
11. Chen Y, Liu W, McPhie DL, Hassinger L, Neve RL. APP-BP1 mediates APP-induced apoptosis and DNA synthesis and is increased in Alzheimers disease brain. J Cell Biol. 2003; 163(1): 27-33. doi: 10.1083/jcb.200304003
12. Chen YZ. APP induces neuronal apoptosis through APP-BP1-mediated downregulation of beta-catenin. Apoptosis. 2004; 9: 415-422.
13. Chen Y, Bodles AM, McPhie DL, Neve RL, Mrak RE, W. Griffin WST. APP-BP1 Inhibits Aβ42 Levels by Interacting with Presenilin-1. Molecular Neurodegeneration. 2007; 2: 3. doi: 10.1186/1750-1326-2-3
14. Laifenfeld D, Patzek LJ, Chen Y, Asiala S, Cataldo AM, Neve RL. Rab5 Mediates an APP Signaling Pathway that Leads to Apoptosis. J Neurosci. 2007; 27: 7141-7153. doi: 10.1523/JNEUROSCI.4599-06.2007
15. Chen Y, Bodles AM. Amyloid precursor protein (APP) modulates β-catenin degradation. Journal of Neuroinflammation. 2007; 4: 29. doi: 10.1186/1742-2094-4-29
16. Chen Y, Dong C. Aβ40 and Aβ42 affect cell fate decisions and cell cycle progression in neural precursor cells. Cell Death and Differentiation. 2009; 16: 386-394.
17. Mao XR, Moerman-Herzog, AM, Chen Y, Barger SW. Unique aspects of transcriptional regulation in neurons-nuances in NFƙB and Sp1-related factors. Journal of Neuroinflammation. 2009; 6: 16. doi: 10.1186/1742-2094-6-16.
18. Chen Y, Neve RL, Liu H. Neddylation dysfunction in Alzheimers disease. Journal of Molecular and Cellular Medicine. 2012; 16(11): 2583-2591. doi: 10.1111/j.1582-4934.2012.01604.x.
19. Liu HC, Enikolopov G, Chen Y. Cul4B regulates neural progenitor cell growth. BMC Neuroscience. 2012; 13: 112. doi: 10.1186/1471-2202-13-112.
20. Chen Y, Neve RN, Zheng H, Griffin WST, Barger SW, Mrak RE. Cycle on Wheels: Is APP Key to the AppBp1 Pathway? Austin Alzheimers & Parkinsons Disease. 2014; 1(2): 7.

Yunlei Yang, PhD, MD

Principal Investigator
Assistant Professor
Department of Neuroscience and Physiology
State University of New York Upstate Medical University
Syracuse, New York, USA

BiographyResearch InterestScientific ActivitiesPublications
Education


• Xinxiang Medical College, China , MD, (1997), Medicine
• Huazhong University of Sci and Tech., China , MS, (2000), Medicine
• Institute of Neuroscience, CAS, China, PhD, (2003), Neuroscience
• The Rockefeller University, New York, NY , Post PhD, (2003-2006), Neuroscience
• Mount Sinai School of Medicine, New York, NY, Post PhD, (2006-2009), Neurology


Positions and Employment


• (2009-2012) Research Specialist, Janelia Farm Research Campus, HHMI
• (2012-2014) Principal Investigator and Assistant Professor, Neuroscience and Physiology, Upstate Medical University of SUNY

His research interests include: Mapping and Manipulating the neural circuits controlling feeding using approaches including Cell type-specific Electrophysiology, Optogenetics and Pharmacogenetics. Specifically, his laboratory focuses on determining the neuronal populations in brain responsible for Feeding, and then manipulating these neurons to modulate feeding behaviors in animals. Importantly, they will also investigate the similar neuronal circuits in obese animals and manipulate the neural circuits to reduce food intake and body weight using similar techniques. Collectively, the knowledge and findings from the studies in his lab will be critical for the development of new therapeutic strategies to treat obesity and other eating disorders.

HONORS


• (2011) Chinese National Natural Sciences Second Awards New functions of Glia
• (2008) Shanghai Science and Technology Advanced Award

Selected Peer-Reviewed Publications and Manuscripts


1. Tian L, Yang Y, Wysocki LM, Arnold A, et al. Selective esterase-ester pair for targeting small molecules with cellular specificity. Proc Natl Acad Sci USA. 2012; 109: 4756-4761. doi: 10.1073/pnas.1111943109
2. Yang Y, Atasoy D, Su H, Sternson SM. Hunger states switch a flip-flop memory circuit via a synaptic AMPK-dependent positive feedback loop. Cell. 2011; 146: 992-1003. doi: 10.1016/j.cell.2011.07.039
3. Yang Y, Zhou Q. Spine modifications associated with long-term potentiation. The Neuro scientist. 2009; 15: 464-476. doi: 10.1177/1073858409340800
4. Yang Y, Wand XB, Frerking M, Zhou Q. Spine expansion and stabilization associated with long term potentiation. J Neuro science. 2008; 28: 5740-5751. doi: 10.1523/JNEUROSCI.3998-07.2008
5. Wang XB, Yang Y, Zhou Q. Independent expression of synaptic and morphological plasticity associated with long-term depression. J Neuro science. 2007; 27: 12419-12429. doi: 10.1523/JNEUROSCI.2015-07.2007
6. Yang Y. Astrocyte: a potential target for the treatment of anorexia nervosa. Neuro Open J. 2015; 2(1): 42-44. doi: 10.17140/NOJ-2-110

Igor Grachev, MD, PhD

Global Clinical Development Leader
TEVA Branded Pharmaceuticals
USA

BiographyResearch InterestScientific ActivitiesPublications

At present Igor Grachev, MD, PhD is a New Growth Franchise Global Head, Clinical, Medical and Drug Safety, Novartis Consumer Health, Inc, Parsippany, New Jersey. Before he was a Neurologist, Psychiatrist, Neuroscientist, Drug Developer, Translational Medicine/POC, Clinical Development, Medical Affairs and Imaging expert with over 20 years of extensive Pharma industry, academic and CRO biomedical research experience who has had roles of increasing responsibility and scope at MGH/Harvard Medical School, SUNY Upstate Medical University, Schering-Plough, Sanofi-Aventis, Merck, BioClinica, Merck Sharp & Dohme Corp, GE Healthcare, and Novartis Consumer Health. All his industry roles have involved the application of imaging, biomarkers and clinical neuroscience to drug development.

His research interests include: Neurobiology of Neurodegenerative disorders (Parkinson’s disease, Alzheimer’s disease, Multiple Sclerosis), Insomnia (incl. PSG), OCD, Depression, Anxiety, Schizophrenia, ADHD, Migraine, Acute & Chronic Pain, Stroke and other indications. Expert in clinical biomarkers and the following Imaging modalities: PET, SPECT, and MRI (Gd-MRI, vMRI, fMRI, MRS, DCE-MRI).

Dr. Grachev is a member of the Coalition Against Major Diseases (CAMD), QIBA DCE-MRI, FDG- and amyloid-PET steering committees of RSNA, ADNI and ADNI2, Society of Nuclear Medicine, International Society to Advance Alzheimer Research and Treatment. He served as a Chair of Industry Scientific Advisory Board for Parkinson’s Progression Markers Initiative, Michael J. Fox Foundation, 2010-2011.

He has written and co-authored over 100 clinical research scientific publications including chapters on imaging biomarkers/technologies in three books.
1. Grachev I. Methods in Pain Research. CRC Press.
2. Grachev I. Complex Regional Pain Syndrome. IASP Press
3. Grachev I. Imaging in CNS Drug Development. Springer Science NY.

Antonios Kerasnoudis, MD, PhD

Neuroimmunological Department
St.Luke Hospital
Thessaloniki
Ethnikis Antistasis 18, Serres
Greece

BiographyResearch InterestScientific ActivitiesPublications

Dr. Kerasnoudis was born in Serres, Greece in 1983. In 2007 he graduated from the Medical School of the Aristotle University in Thessaloniki Greece.In 2009 he began his neurological residency in the Department of Neurology of the St.Josef Hospital Ruhr University Bochum in Germany which he completed at the end of 2013. He is board certified for electromyography neuromuscular ultrasound and extracranialintracranial Doppler ultrasound from the German and European Neurosonology Society.His clinical and research work focuses on the applications of ultrasound in clinical practice.
Dr. Kerasnoudis is the principal investigator of various nerve ultrasound studies on immune mediated neuropathies. His main scientific contributions are the detection of possible distribution patterns of pathological nerve ultrasound changes in immunemediated neuropathies such as the Guillain Barre syndrome (GBS) the multifocal motor neuropathy (MMN) and the chronic inflammatory demyelinating polyneuropathy (CIDP).His nerve ultrasound group based in Bochum Germany and Greece introduced for the first time in the literature a novel ultrasound score Bochum Ultrasound Score, allowing the differentiation of the CIDP from GBS in the acutesubacute phase. On March 2014 he won in Berlin the Young Investigator Award from the International Federation of Clinical Neurophysiology,IFCN for his scientific work and publications on neuromuscular ultrasound.
Dr. Kerasnoudis is co author of three books on neuromuscular ultrasound and author of many peer reviewed original articles. He is member of the German and Greek Neurological Society and enlisted in the editorial board and reviewer list of several journals of international repute

His research interests include: Applications of ultrasound in clinical practice and Neuromuscular ultrasound in immune-mediated neuropathies

AFFILIATIONS

• Greek Academy of Neurology
• German Academy of Neurology
• German Academy of Clinical Neurophysiology und functional Imaging (DGKN)
• European Society of Neurosonology and Cerebral Hemodynamics (ESNCH)


ACADEMIC HONORS


• Young Investigator Award from the International Federation of Clinical Neurophysiology (IFCN)
• Headache in Stroke 1st scientific prize in the 3. Medical Congress of the Aristoteles University of Thessaloniki, Greece

1.Kerasnoudis A, Pitarokoili K, Behrendt V, Gold R, Yoon M. Correlation of nerve ultrasound, electrophysiological and clinical findings in chronic inflammatory demyelinating polyneuropathy. J Neuroimaging. 2014. doi: 10.1111/jon.12079
2.Kerasnoudis A, Pitarokoili K, Behrendt V, Gold R, Yoon M. Nerve ultrasound score in distinguishing chronic from acute demyelinating polyneuropathy. Clin Neurophysiology. 2013. doi: 10.1016/j.clinph.2013.08.014
3.Kerasnoudis A, Pitarokoili K, Behrendt V, Gold R, Yoon M. Correlation of nerve ultrasound, electrophysiological and clinical findings in post Guillain-Barre syndrome. J Peripher Nerv Syst. 2013; 18(3): 232-240. doi: 10.1111/jns5.12037
4.Kerasnoudis A, Decard B, Gold R. Clinical Reasoning: A 48-year-old woman with progressive spastic-ataxic gait. Neurology. 2013; 81(11): e75-e80. doi: 10.1212/WNL.0b013e3182a43ad9
5.Kerasnoudis A. Elongated muscle belly of the flexor digitorum superficial causing carpal tunnel syndrome. HAND. 2012; 7: 333-334. doi: 10.1007/s11552-012-9435-z
6.Kerasnoudis A. Neuromuscular ultrasound in carpal tunnel syndrome: a tool for cutting a gordian knot. Pain Physician. 2013; 16(4): E446-E448.
7.Kerasnoudis A, Pitarokoili K, Behrendt V, Gold R, Yoon M. Cross sectional area reference values for sonography of peripheral nerves and brachial plexus. Clin Neurophysiol. 2013; 124(9): 1881-1888. doi: 10.1016/j.clinph.2013.03.007
8.Kerasnoudis A. Ultrasonography for Diagnosing Carpal Tunnel Syndrome: A Meta-analysis of Diagnostic Test Accuracy. Ultrasound Med Biol. 2013.
9.Kerasnoudis A. Intranerve cross sectional area variability of tibial nerve in diabetic neuropathy. European Journal of Radiology. Eur J Radiol. 2013. doi: 10.1016/j.ejrad.2013.02.035
10.Kerasnoudis A. Which ultrasound method has the upper hand in the follow-up of the patients with recurrent carpal tunnel syndrome Annals of Rheumatic Diseases. Ann Rheum Dis. 2013. doi: 10.1136/annrheumdis-2013-203206
11.Kerasnoudis A, Pitarokoili K. Ulnar nerve reference values for cross-sectional area, intranerve variability and side to side difference ratio. Rheumatology International. Rheumatol Int. 2013. doi: 10.1007/s00296-013-2708-1
12. Kerasnoudis A. Re: Ultrasonographic Findings in Chronic Inflammatory Demyelinating Polyneuropathy. Am J Phys Med Rehabil. 2013. doi: 10.1097/PHM.0b013e318282cfe9
13.Kerasnoudis A, Yoon MS. Relapsing neuromas: a therapeutic challenge Clin. J Pain. 2013; 29(3): 280. doi: 10.1097/AJP.0b013e318274b15e
14.Kerasnoudis A, Meves SH, Gold R, Krogias C. Correlation between Frequency of Microembolic Signals and Efficacy of Antiplatelet Therapy in Symptomatic Carotid Disease. J Neuroimaging. 2013. doi: 10.1111/j.1552-6569.2012.00770.x
15.Kerasnoudis A. Nerve ultrasound in a case of chronic inflammatory demyelinating neuropathy. Muscle Nerve. 2012. doi: 10.1002/mus.23624
16.Kerasnoudis A. Correlation of Sonographic and Electrophysiological Findings in a Patient with Multifocal Motor Neuropathy. J Neuroimaging. 2012. doi: 10.1111/j.1552-6569.2012.00757.x
17.Kerasnoudis A. Ultrasonographic assessment of longitudinal median nerve and hand flexor tendon dynamics in carpal tunnel syndrome. Muscle Nerve. 2012; 46(6): 981-982. doi: 10.1002/mus.23476
18.Kerasnoudis A. Could sonographically guided percutaneous needle release of the carpal tunnel also play an important role in the treatment of recurrent carpal tunnel syndrome. J Ultrasound Med. 2012; 31(12): 2048-2049.
19.Kerasnoudis A, Klasing A, Behrendt V, Gold R, Yoon M. Intra- and internerve cross-sectional area variability: new ultrasound measures. Muscle Nerve. 2013; 47(1): 146-147. doi: 10.1002/mus.23520
20.Kerasnoudis A, Manente G, Melchionda D, et al. Changes in the carpal tunnel while wearing the Manu soft hand brace: a sonographic study. J Hand Surg Eur. 2012; 1753193412446112(37(8)): 801. doi: 10.1177/1753193412455893
21.Kerasnoudis A.Ultrasound and MRI in carpal tunnel syndrome: the dilemma of simplifying the approach to a complex disease or making complex assessments of a simple problem. J Hand Surg Am. 2012; 37(10): 2200-22001. doi: 10.1016/j.jhsa.2012.07.041
22.Kerasnoudis A, Gold R, Yoon M. Clinical reasoning: a 48-year-old woman with recurrent headache, transient neurologic symptoms, and CSF pleocytosis. Neurology. 2012; 79(7): e59-e62. doi: 10.1212/WNL.0b013e3182648b3c
23.Kerasnoudis A. Ultrasonography in severe carpal tunnel syndrome. Muscle Nerve. 2012; 46(2): 296-297. doi: 10.1002/mus.23396
24. Kerasnoudis A. Ultrasonography of MADSAM neuropathy: focal nerve enlargements at sites of existing and resolved conduction blocks. Neuromuscul Disord. 2012; 22(11): 1032. doi: 10.1016/j.nmd.2012.06.009
25. Tsivgoulis G, Kerasnoudis A, Krogias C, et al. Clopidogrel load for emboli reduction in patients with symptomatic carotid stenosis undergoing urgent carotid endarterectomy. Stroke. 2012; 43(7): 1957-1960. doi: 10.1161/STROKEAHA.112.657916
26.Kerasnoudis A, Ellrichmann G, Gold R, Saft C. Teaching Video NeuroImages: spinal and bulbar muscular atrophy mimicking essential tremor. Neurology. 2012; 78(6): e41. doi: 10.1212/WNL.0b013e318245d2bd
27. Kerasnoudis A, Rockhoff M, Federlein J, Gold R, Krogias C. Isolated ZIC4 antibodies in paraneoplastic cerebellar syndrome with an underlying ovarian tumor. Arch Neurol. 2011; 68(8): 1073. doi: 10.1001/archneurol.2011.176
28. Kerasnoudis A. The role of neuromuscular ultrasound in the diagnostic of the chronic inflammatory demyelinating polyneuropathy. European Neurological Review. 2013; 8: 62-64.
29. Kerasnoudis A. The Diagnostic Role of Neuromusclar Ultrasound in Chronic Inflammatory Demyelinating Polyneuropathy. Neuro Open J. 2014; 1(1): 1-6. 10.17140/NOJ-1-101

Xiaoyun Liang, PhD

Imaging Division
Florey Institute of Neuroscience and Mental Health
The University of Melbourne
245 Burgundy Street
Heidelberg, 3084, Australia

BiographyResearch InterestScientific ActivitiesPublications

Dr. Liang is a Magnetic Resonance (MR) physicist in The Florey Institute of Neuroscience and Mental Health, University of Melbourne. After obtaining his PhD degree from Southeast University in 2005, he joined Shanghai University as a lecturer. He finished his postdoctoral training in Brandeis (2007-2008) and Vanderbilt University (2008-2009) in USA. Since 2010, he moved to The Florey Institute of Neuroscience and Mental health as a senior research fellow. He is an expert in Magnetic Resonance Imaging (MRI), especially arterial spin labelling perfusion MRI. He is mainly focusing on advanced MRI development, with the aim of applying new methods, especially neuro imaging, to important clinical and neuro scientific problems, in particular in the field of epilepsy, stroke and Alzheimers disease.

His research interests include: Arterial spin labeling perfusion MRI, Magnetic resonance imaging, MRI pulse sequence development, Brain connectivity, Integration of structural and functional brain connectivity, Medical image processing and analyses and Machine leaning and pattern recognition.

ASSOCIATION MEMBERSHIPS


• International society for Magnetic Resonance in Medicine, Member

1. Liang X, Connelly A, Tournier D, Calamante F. Physics in Medicine and Biology. 2014; 59: 5559-5573. doi: 10.1088/0031-9155/59/18/5559.
2. Liang X, Connelly A, Calamante F. Graph analysis of resting-state ASL perfusion MRI data: Nonlinear correlations among CBF and network metrics. NeuroImage. 2014; 87: 265-275. doi: 10.1016/j.neuroimage.2013.11.013
3. Liang X, Connelly A, Calamante F. Improved partial volume correction for single inversion time arterial spin labeling data. Magnetic Resonance in Medicine. 2013; 69: 531-537. doi: 10.1002/mrm.24279
4. Liang X, Tournier D, Masterton R, Connelly A, Calamante F. A k-space sharing 3D GRASE pseudo-continuous ASL method for whole-brain resting-state functional connectivity. International Journal of Imaging Systems and Technology. 2012; 22(1): 37-43. doi: 10.1002/ima.22006
5. Liang X, Zebrowitz L, Zhang Y. Neural Activation in the ‘Reward- Circuit’ Shows a Nonlinear Response to Facial Attractiveness. Social Neuroscience. 2010; 5(3): 320-334. doi: 10.1080/17470911003619916.
6. Liang X, Zebrowitz L, Aharon I. Effective Connectivity between Amygdala and Orbitofrontal Cortex Differentiates the Perception of Facial Expressions. Social Neuroscience. 2009; 4(2): 185-196. doi: 10.1080/17470910802453105
7. Zeng W, Liang Z, Wang Z, Fang Z, Liang X, Luo L. Decimative Subspace-based Parameter Estimation Methods of Magnetic Resonance Spectroscopy based on Prior Knowledge. Magnetic Resonance Imaging. 2008; 26(3): 401-412. doi: http://dx.doi.org/10.1016/j.mri.2007.08.004
8. Liang X, Zeng W, Luo L. Non-uniform MR Image Reconstruction Based on Non-uniform FFT. Proc SPIE. 2007. br> 9. Zheng Wang, Zhang P, Liang X, Luo L. Mesh simplification algorithm based on moments. Journal of Circuit and System. 2006; 11(5): 107-110.
10. Wang Z, Shu H, Luo L, Liang X, Zhang P. Tetrahedron Mesh-Cut Algorithm Based on Projective Method. Journal of Data Acquisition and Processing. 2006; 21(4): 423-427.
11. Zeng W, Liang X, Luo L. A Preprocessing Quantification Method for MRS Signal based on Complex PCA. Journal of Electronic & Information Technology. 2005; 27(1): 51-55.
12. Zeng W, Liang X, Luo L. One Quantitative Method based on Total Least Squares for Frequency-selective Magnetic Resonance Spectroscopy. Acta Electronica Sinica. 2005; 33(7): 1209-1212.
13. Zeng W, Liang X, Luo L. Decimative Subspace-based Parameter Estimation Methods of Magnetic Resonance Spectroscopy. Journal of Computer. 2005; 29(12): 2226-2231.
14. Wang Z, Zhang P, Liang X, Zhou Z, Luo L. GGCV Method for Image Segmentation Based on HSV. Journal of Data Acquisition and Processing. 2005; 20: 394-397.
15. Liang X, Zeng W, Luo L. PDE-Based MRI Image Denoising. Signal Processing. 2004; 3: 318-321.
16. Liang X, Zeng W, Luo L. Wavelet Bank Filter Based Optical Flow Estimation. Journal of Data Acquisition and Processing. 2004; 19(1): 78-81.
17. Liang X, Zhang P, Wang W, Zeng W. Medical Image Registration using Hausdorff Distance Combined with Genetic Algorithm. Journal of Scientific Instrument. 2004; 4: 535-537.
18. Zeng W, Luo L, Liang X, Wang S, Guo S. Wavelet Based fMRI Image Denoising. Journal of Applied Science. 2004; 1: 118-123.
19. Zeng W, Liang X, Luo L. Automatic Damping Factor Alignment in MRS Based on Complex Principal Component Analyses. Journal of Circuit and System. 2004; 2: 84-87.
20. Zhang P, Zhao H, Liang X. Face Detection and Validation Method in Complex Background. Journal of Data Acquisition and Processing. 2004; 1: 10-15.
21. Liang X, Luo L, Zeng W. Level Set Method Based Medical Image Segmentation. Journal of Circuit and System. 2003; 6: 77-81.

Minho Moon, PhD

Associate Professor
Department of Biochemistry
College of Medicine
Konyang University
Daejeon 302-718, Republic of Korea

BiographyResearch InterestScientific ActivitiesPublications

Dr. Moon received his BSc in Biology from Kyung Hee University, Seoul, Korea. He obtained MS in Department of Anatomy and Neurobiology, Kyung Hee University School of Medicine and PhD in Department of Pharmacology, Kyung Hee University School of Medicine, and Seoul, Korea. He was appointed as an Instructor in Department of Psychiatry at Harvard Medical School in 2014. At present, he is an Associate Professor, in the Department of Biochemistry, at the College of Medicine, Konyang University, Republic of Korea.

His research interests includes: Elucidation of pathology or pathogenic mechanisms in human postmortem brain tissue and animal models of CNS disorders, Drug development or examination of therapeutic potential of natural compounds, small molecules, physical exercise, and endogenous proteins in animal models of CNS disorders, Development of strategies to repair the damaged brain through transplantation of stem cells, Examination of stem cells trafficking in Alzheimers and Parkinsons brain, Elucidation of pathology and pathogenesis of Alzheimers disease and Parkinsons disease in patients-derived induced Pluripotent stem cells, Drug development for Alzheimers disease and Parkinsons disease treatment using patients-derived induced Pluripotent stem cells, Development of strategies to repair the damaged brain through enhancement of Adult neurogenesis, Examination of spontaneous or manipulated repair of noradrenergic, Septohippocampal cholinergic, Dopaminergic visual circuitry in animal models for neurological disorders using genetic tracing.

In 2009, he joined the laboratory for Alzheimers disease research at Seoul National University College of Medicine, Korea, where he acted as Post-doctoral fellow and Research Assistant Professor.

1. Yoon M, Moon M, Jeong JW, et al. The effects of repeated restraint stress on the synaptic plasticity in the inner molecular layer of mouse dentate gyrus. Korean J Phys Anthropol. 2006; 19(4): 325-337.
2. Moon M, Park C. Temporal Changes of Post Synaptic Signaling Molecules, Post Synaptic Density-95 and Neuronal Nitric Oxide Synthase, in the Inner Molecular Layer of the Mouse Dentate Gyrus during Voluntary Running. Anatomy & Cell Biology. 2006; 39(1): 55-62.
3. Moon M, Huh Y, Park C. L-nitroimidazole ornithine limits exercise-induced increases in cell proliferation in the hippocampus of adult mice. NeuroReport. 2006; 17(2): 1121-1125. doi: 10.1097/01.wnr.0000224767.84830.1b
4. Chung H, Seo S, Moon M, Park S. IGF-I inhibition of apoptosis is associated with decreased expression of prostate apoptosis response-4. Journal of Endocrinology. 2007; 194(1): 77-85.
5. Chung H, Seo S, Moon M, Park S. Phosphatidylinositol-3-kinase/Akt/ glycogen synthase kinase-3 beta and ERK1/2pathways mediate protective effects of acylated and unacylated ghrelin against oxygen-glucose deprivation-induced apoptosis in primary rat cortical neuronal cells. Journal of Endocrinology. 2008; 198(3): 511-521. doi: 10.1677/JOE-08-0160
6. Moon M, Kim HG, Hwang L, et al. Neuroprotective effect of ghrelin in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinsons disease by blocking microglial activation. Neurotoxicity Research. 2009; 15: 332-347. doi: 10.1007/s12640-009-9037-x
7. Hwang S, Moon M, Kim S, Hwang L, Ahn KJ, Park S. Neuroprotective effect of ghrelin is associated with decreased expression of prostate apoptosis response-4. Endocrine Journal. 2009; 56(4): 609-617. doi: http://dx.doi.org/10.1507/endocrj.K09E-072
8. Moon M, Kim S, Hwang L, Park S. Ghrelin regulates hippocampal neurogenesis in adult mice. Endocrine Journal. 2009; 56(3): 525-531. doi: http://dx.doi.org/10.1507/endocrj.K09E-089
9. Kim S, Moon M, Park S. Exendin-4 protects dopaminergic neurons by inhibition of microglial activation and matrix metalloproteinase-3 expression in an animal model of Parkinsons disease. Journal of Endocrinology. 2009; 202(3): 431-439. doi: 10.1677/JOE-09-0132
10. Hong HS, Hwang JY, Son SM, Kim YH, Moon M, Jung IM. FK506 reduces amyloid plaque burden and induces MMP-9 in AβPP/PS1 double transgenic mice. Journal of Alzheimers Disease. 2010; 22(1): 97-105. doi: 10.3233/JAD-2010-100261
11. Choi JG, Moon M, UkJeong H, Kim MC, Kim SY, MyungSook Oh. CistanchesHerba enhances learning and memory by inducing nerve growth factor. Behavioural Brain Research. 2010; 20(216(2)): 652-658. doi: 10.1016/j.bbr.2010.09.008
12. Moon M, Choi JG, Nam DW, et al. Ghrelin ameliorates cognitive dysfunction and neurodegeneration in intrahippocampal Aβ (1-42) oligomer-injected mice. Journal of Alzheimers Disease. 2010; 1(23(1)): 147-159. doi: 10.3233/JAD-2010-101263
13. Choi JG, Moon M, Kim HG, et al. Gami-Chunghyuldan ameliorates memory impairment and neurodegeneration induced by intrahippocampal Aβ(1-42) oligomer injection. Neurobiology of Learning and Memory. 2011; 96(2): 306-314. doi: 10.1016/j.nlm.2011.06.004
14. Moon M, Hong HS, Nam DW, et al. Intracellular Aβ accumulation in calcium-binding protein-deficient neurons leads to Aβ plaque formation in animal models of Alzheimers disease, Journal of Alzheimers Disease. 2012; 29(3): 615-628. doi: 10.3233/JAD-2011-111778.
15. Kim KH, Moon M, Yu SB, Jung IM, Kim JI. RNA-Seq Analysis of Frontal Cortex and Cerebellum from 5XFAD mice at Early Stage of Disease Pathology. Journal of Alzheimers Disease. 2012; 29(4): 793-808. doi: 10.3233/JAD-2012-111793
16. Kook SY, Hong HS, Moon M, Ha CM, Chang S, Jung IM. A1-42-RAGE interaction disrupts tight junctions of the blood brain barrier via Ca2+-calcineurin signalling. Journal of Neuroscience. 2012; 27(32(26)): 8845-8854. doi: 10.1523/JNEUROSCI.6102-11.2012
17. Moon M, Song H, Hong HJ, et al. Vitamin D-binding protein interacts with Aβ and suppresses Aβ-mediated pathology. Cell death and differentiation. 2013; 20(4): 630-638. doi: 10.1038/cdd.2012.161
18. Hong I, Kang T, Yoo YC, et al. Quantitative Proteomic Analysis of the Hippocampus in the 5XFAD Mouse Model at Early Stages of Alzheimers Disease Pathology. Journal of Alzheimers Disease. 2013; 1(36(2)): 321-334. doi: 10.3233/JAD-130311
19. Kook SY, Hong HS, Moon M, Jung IM. Disruption of blood-brain barrier in Alzheimer disease pathogenesis. Tissue Barriers. 2013; 1(2): e23993. doi: 10.4161/tisb.23993
20. Kim HG, Moon M, Choi JG, et al. Donepezil inhibits the amyloid-beta oligomer-induced microglial activation in vitro and in vivo. Neurotoxicology. 2013; 40C: 23-32. doi: 10.1016/j.neuro.2013.10.004
21. Moon M, Cha MY, Jung IM. Impairment of adult hippocampal neurogenesis in the 5XFAD mouse model of Alzheimers disease. Journal of Alzheimers Disease. 2014; 41(1): 233-241.
22. Baik SH, Cha MY, Hyun YM, et al. Migration of neutrophils targeting amyloid plaques in Alzheimers disease mouse model. Neurobiology of Aging. 2014; 35(6): 1286-1292. doi: 10.1016/j.neurobiolaging.2014.01.003
23. Moon M, Choi JG, Kim SY, Myung Sook Oh. Bombycis excrementum reduces amyloid beta oligomer-induced memory impairments, neurodegeneration, and neuroinflammation in mice. Journal of Alzheimers Disease. 2014; 41(2): 599-613. doi: 10.3233/JAD-140270
24. Moon M, Kim HG, Choi JG, et al. 6-Shogaol, an active constituent of ginger, attenuates neuroinflammation and cognitive deficits in animal models of dementia. Biochemical and Biophysical Research Communications. 2014; 20(449(1)): 8-13. doi: 10.1016/j.bbrc.2014.04.121
25. Lim SM, Moon M, Hyein Oh, Kim HG, Kim SY, Oh MS. Ginger improves cognitive function via NGF-induced ERK/CREB activation in the hippocampus of the mouse. The Journal of Nutritional Biochemistry. 2014; 25(10): 1058-1065. doi: 10.1016/j.jnutbio.2014.05.009
26. Kim TG, Yao R, Monnell T, et al. Efficient specification of interneurons from human Pluripotent stemcells by dorsoventral and rostrocaudal modulation. Stem cells. 2014; 32(7): 1789-804. doi: 10.1002/stem.1704
27. Kook SY, Jeong H, Kang MJ, et al. Crucial role of calbindin D-28k in the pathogenesis of Alzheimers disease mouse model. Cell death and differentiation. 2014; 21(10): 1575-1587. doi: 10.1038/cdd.2014.67
28. Song H, Chang YJ, Moon M, et al. Inhibition of Glutaminyl Cyclase Ameliorates Amyloid Pathology in an Animal Model of Alzheimers Disease via the Modulation of γ-Secretase Activity. Journal of Alzheimers Disease. doi: 10.3233/JAD-141356. doi: 10.3233/JAD-141356
29. Moon M, Jeong I, Kim CH, et al. Correlation between Orphan Nuclear Receptor Nurr1 expression and Amyloiddeposition in 5XFAD mice, an animal model of Alzheimers disease, Journal of Neurochemistry. doi: 10.1111/jnc.12935 doi: 10.1111/jnc.12935
30. Byun J, Son SM, Cha MY, et al. CR6-interacting factor 1 is a key regulator in Aβ-induced mitochondrial disruption andpathogenesis of Alzheimers disease. Cell death and differentiation. 2014. doi: 10.1038/cdd.2014.184
31. Cunningham M, Leung A, Ahn S, et al. Human PSC-derived maturing GABAergic interneurons ameliorate seizures and abnormal behavior in epileptic mice. Cell Stem Cell. 2014; 15(5): 559-573. doi: http://dx.doi.org/10.1016/j.stem.2014.10.006

Peter Schmidt, PhD

CIO and Vice President, Research and Professional Programs
National Parkinson Foundation
200 SE 1st St, Suite 800
Miami, FL 33131, USA

BiographyResearch InterestScientific ActivitiesPublications

Dr. Schmidt joined National Parkinson Foundation (NPF) as Chief Information Officer (CIO) and Vice President, Research and Professional Programs in June 2009 where he is responsible for the Parkinson’s Outcomes Project, a longitudinal study of Parkinson’s disease to identify best practices in care to achieve optimal patient-reported and clinically measured outcomes. With over 15,000 clinical evaluations of over 7,000 patients, the Parkinson’s Outcomes Project is the largest clinical study of Parkinson’s disease ever conducted and includes the largest set of patient-reported outcome measures ever collected in a prospective study. Prior to NPF, Schmidt was an investment banker in Norwalk, CT., president a software company supporting chronic disease management, and COO of an on-line education joint venture of Oxford, Stanford, and Yale universities. He is an active member of several trade groups and is widely published in both scientific and trade journals on issues around medicine, health information technology and finance. Dr. Peter Schmidt earned his bachelor’s degree at Harvard University and was awarded an M.S. and Ph.D. from Cornell University, Sibley School of Mechanical Engineering where he studied gait and balance and total joint replacement. He completed a fellowship at the Hospital for Special Surgery in New York.

His main focus is on Parkinsons disease

EXPERIENCE

With a staff of 9 including program and grants managers, oversaw a growing suite of programs designed to engage people with Parkinson’s and improve outcomes. Initiatives addressed research, outreach, and professional and patient education, often using innovative technology to achieve business objectives.


ACCOMPLISHMENTS

Led strategically and operationally a quality improvement program consisting of a “big data” clinical study and a translational program to bring findings from the study into clinical practice.


Accomplishments include the following:

•Launched and led the largest clinical study in Parkinson’s disease ever conducted, NPF’s Quality Improvement Initiative, from the first patient recruited at launch with six centers to over 6,000 subjects at 20 centers with over 10,000 clinical evaluations and 1,000,000 data elements, with a budget of approximately $1 million per year.
• Developed strategic research roadmap for QII including recruiting researchers, collaborating in the research process, and ensuring that NPF’s research goals were addressed in over 20 papers, presentations, and guidelines.
• Leveraged this experience to give presentations and lectures at scientific venues and as a consultant or advisor to other organizations pursuing similar aims, including the National Library of Medicine, American Academy of Neurology’s Practice Improvement Subcommittee, the National Quality Forum, and the Cure Huntington’s Disease Initiative.
For more information, see http://tinyurl.com/NPF-QII

• Oversaw scientific grants of $5 million+ awarded in a peer reviewed process. Updated grant reporting process and hired a director of research. Linked research results to fundraising efforts, including developing reports for prospective and current donors on research.
• Launched a website and smartphone app for professionals on Parkinson’s care with over 10,000 unique users.
• Revised the foundation’s $2 million/year Center of Excellence program, introducing a peer-review site visit and personally conduction reviews of over 20 academic medical centers.

• Oversaw a $7-8 million annual program budget including scientific grants, numerous conferences, symposia, consensus meetings, and sponsored sessions and delivered numerous talks and co-authored papers on Parkinson’s, Parkinson’s care, and neuroscience.

SELECTED PUBLICATIONS

1.Hassan A, Wu S, Schmidt P, et al. What are the issues facing Parkinsons disease patients at ten years of disease and beyond: Data from the NPF-QII study. Parkinsonism and Related Disorders. 2012. doi: 10.1016/j.parkreldis.2012.06.014
2.Schmidt P, Okun M. Improving the quality of care in Parkinsons disease. Nature Reviews Neurology. 2011; 7: 196-197.
3.Aminoff M, Christine C, Friedman J, et al. Management of the hospitalized patient with Parkinson’s disease: Current state of the field and the need for guidelines. Parkinsonism and Related Disorders. 2010; 17: 139-145. doi: 10.1016/j.parkreldis.2010.11.009
4. Chou K, Zamudio J, Schmidt P, et al. Hospitalization in Parkinsons disease: a survey of National Parkinson Foundation Centers. Parkinsonism and Related Disorders. 2011; 17(6): 440-445. doi: 10.1016/j.parkreldis.2011.03.002
5. Go C, Rosales R, Schmidt P, Lyons K ,Pahwa R, Okun M. Generic versus branded pharmacotherapy in Parkinson’s disease: Does it matter A review. Parkinsonism and Related Disorders. 2011; 17(3): 139-145. doi: 10.1016/j.parkreldis.2011.02.005
6. Okun M, Siderowf A ,Nutt J, et al. Piloting the NPF data-drive quality improvement initiative. Parkinsonism and Related Disorders. 2010; 16(8): 517-521. doi: 10.1016/j.parkreldis.2010.06.005
7. Schmidt P. Re-aligning Healthcare. Health Management Technology. 2009.
8. Schmidt P. State of Play: The Orthopedic M and A Market and the Credit Crunch. Orthopedic Design and Technology. 2007.
9. Robie B, Rosenthal D, Schmidt P. Retaining mechanism for a modular tibial component of a knee prosthesis. United States Patent. 6126692.
10. Hardie R, Flanders J Schmidt P, Credille K, Pedrick T, Short C. Biomechanical and histological evaluation of a laparoscopic stapled gastropexy technique in dogs. Veterinary Surgery. 1996; 25(2): 127-133.

Dirk M. Hermann, MD

Chair for Vascular Neurology and Dementia
Department of Neurology
University Hospital Essen (AöR)
Hufelandstraße 55
D-45122 Essen
Germany

BiographyResearch InterestScientific ActivitiesPublications

Dr. Dirk M Hermann studied medicine at the University of Gießen, Germany. After completing postdoctoral fellowships at the Max Planck Institutes in Munich and Cologne, he pursued his clinical training at University Hospitals in Tübingen and Zurich. He is now the Chair for Vascular Neurology and Dementia, at the University Hospital Essen, working on neurovascular remodelling and brain plasticity with special focus on ischaemic stroke.

His expertise includes: Stroke, Neurodegeneration, Dementia, Neurogeriatrics, Neuroplasticity.

STROKE: BASIC / TRANSLATION RESEARCH

PATHOPHYSIOLOGY AND EXPERIMENTAL TREATMENT OF ISCHEMIC STROKE


Using experimental methods we investigate degenerative and restorative processes in the circulation disturbed brain. A particular focus of our work is the characterization of the role of the vasculature in stroke pathophysiology and the role of the neurovascular unit during the stroke function restitution. We explore basics of pharmacological therapies and evaluate novel , focused on function recovery treatment concepts.


BASICS NEUROPROTECTIVE STROKE THERAPIES IN HUMANS


Central Nervous effective drugs are lipophilic rule and therefore in principle be able to cross the blood -brain barrier. Their accumulation in brain tissue is , however, not determined solely by passive diffusion processes, but influenced by active transport processes. Our group examined the expression of drug transporters at the blood circulation disturbed blood-brain barrier and developed strategies to improve drug accumulation in stroke brain.


CEREBRAL MICROANGIOPATHY : BASIC / TRANSLATIONAL RESEARCH

PATHOPHYSIOLOGY AND EXPERIMENTAL TREATMENT OF CEREBRAL MICROANGIOPATHY

With the help of genetically modified animal models , we investigate damage processes that result in cerebral microangiopathy in damage to the brain parenchyma . Our attention is also here in the characterization of the interactions between the vascular system and brain parenchyma, where we try to use strategies aimed at stabilizing the vascular integrity and function to prevent the progression of microangiopathy and encephalopathy. We do these primarily pharmacological therapies.


PATHOGENESIS AND EARLY DIAGNOSIS OF VASCULAR DEMENTIA


Denial Elle disorders often manifest themselves initially in a preliminary stage with so-called mild cognitive impairment, which has already been noticed in many cases by the patients and their relatives. Using imaging methods (MRI) , blood tests ( DNA polymorphisms , protein assays) and vascular function tests, we examine the causes of vascular dementia and analyze surrogate marker , let those dementing diseases at an early stage (ie , in its preliminary stages ) to predict and influence . Attached to our group is our dementia and memory clinic.

ORIGINAL ARTICLES IN REFEREED JOURNALS


1. Peyron C, Luppi PH, Kitahama K, Fort P, Hermann DM, Jouvet M. Origin of the dopaminergic innervation of the rat dorsal raphe nucleus. Neuroreport. 1995; 6: 2527-2531.
2. Hermann DM, Luppi PH, Peyron C, Hinckel P, Jouvet M. Forebrain projections of the rostral nucleus raphe magnus shown by iontophoretic application of choleratoxin b in rats. Neurosci. Lett. 1996; 216: 151-154.
3. Mullington J, Hermann D, Holsboer F, Pollmächer T. Age dependent suppression of nocturnal growth hormone levels during sleep deprivation. Neuroendocrinology. 1996; 64: 233-241.
4. Pollmächer T, Mullington J, Korth C, et al. Diurnal variations in the human host response to endotoxin. J. Infect. Dis. 1996; 174: 1040-1045. doi: 10.1093/infdis/174.5.1040
5. Pollmächer T, Korth C, Schreiber W, Hermann D, Mullington J.Effects of repeated administration of granulocyte colony-stimulating factor G-CSF on neutrophil counts, plasma cytokine, and cytokine receptor levels.Cytokine. 1996; 8: 799-803.
6. Hermann DM, Luppi PH, Peyron C, Hinckel P, Jouvet M. Afferent projections to the rat nuclei raphe magnus, raphe pallidus and gigantocellular reticularis pars alpha demonstrated by iontophoretic application of choleratoxin subunit b. J. Chem. Neuroanat. 1997; 13: 1-21.
7. Fritze K, Wiessner C, Kuster N, et al. Effect of global system for communication microwave exposure on the genomic response of the rat brain. Neuroscience. 1997; 81: 627-639.
8. Hermann DM, Mullington J, Hinze-Selch D, Schreiber W, Galanos C, Pollmächer T. Endotoxin-induced changes in sleep and sleepiness during the day. Psychoneuroendocrinology. 1998; 23: 427-437. doi: http://dx.doi.org/10.1016/S0306-4530(98)00030-4
9. Hermann DM, Mies G, Hossmann KA. Effects of a traumatic neocortical lesion on cerebral metabolism and gene expression of rats. Neuroreport. 1998; 9: 1249-1253.
10. Hermann DM, Kuroiwa T, Ito U, Mies G. Expression of c-jun, hsp72 and gfap following repeated unilateral common carotid artery occlusion in gerbils - Correlates of delayed ischemic injury. Brain Res. 1998; 799: 35-43.
11. Hermann DM, Mies G, Hossmann KA. Effects of a traumatic neocortical lesion on cerebral metabolism and gene expression of rats. Neuro report. 1998; 9: 1917-1921.
12. Kilic E, Hermann DM, Hossmann KA. A reproducible model of thromboembolic stroke in mice. Neuroreport . 1998; 9: 2967-2970.
13. Schuld A, Mullington J, Hermann D, et al. Effects of granulocyte colony-stimulating factor on night sleep in humans. Am. J. Physiol. 1999; 276: 1149-1155.
14. Hermann DM, Mies G, Hossmann KA.Expression of c-fos, junB, c-jun, MKP-1 and hsp72 following traumatic neocortical lesions in rats - Relation to spreading depression. Neuroscience. 1999; 88: 599-608.
15. Hermann DM, Mies G, Hossmann KA.Biochemical changes and gene expression following traumatic brain injury: Role of spreading depression. Restor. Neurol. Neurosci. 1999; 14: 103-108.
16. Kilic E, Hermann DM, Hossmann KA. Recombinant tissue plasminogen activator reduces infarct size after reversible thread occlusion of middle cerebral artery in mice. Neuroreport. 1999; 10: 107-111.
17.Hermann DM, Mies G, Hossmann KA. Lesion-remote metabolic changes after neocortical cold injury in rats. Neuroreport. 1999; 10: 759-763.
18. Mies G, Hermann DM, Ganten U, Hossmann KA. Hemodynamic and metabolism in stroke-prone spontaneously hypertensive rats before manifestation of brain infarcts. J. Cereb. Blood Flow Metab. 1999; 19: 1238-1246. doi: 10.1097/00004647-199911000-00008
19. Mullington J, Korth C, Hermann DM, Orth A, Holsboer F, Pollmächer T. Dose-related effects of endotoxin on nocturnal sleep in humans.Am. J. Physiol. 2000; 278: R947-R955.
20. Schuld A, Mullington J, Friess E, et al. Changes in dehydroepiandrosterone DHEA and DHEA-sulfate plasma levels during experimental endotoxemia in healthy volunteers.J. Clin. Endocrinol. Metab. 2000; 85: 4624-4629. doi: http://dx.doi.org/10.1210/jcem.85.12.7055
21. Hermann DM, Mies G, Hata R, Hossmann KA. Microglial and astrocytic reactions prior to onset of thalamic cell death after traumatic lesion of the rat sensorimotor cortex. Acta Neuropathol. 2000; 99: 147-153.
22. Kilic E, Hermann DM, Hossmann KA. Recombinant tissue-plasminogen activator-induced thrombolysis after cerebral thromboembolism in mice. Acta Neuropathol. 2000; 99: 219-222.
23. Kuroiwa T, Mies G, Hermann D, Hakamata Y, Hanyu S, Ito U. Regional differences in the rate of energy impairment after threshold level ischemia for induction of cerebral infarction in gerbils. Acta Neuropathol. 2000; 100: 587-594.
24. Hata R, Maeda K, Hermann DM, Mies G, Hossmann KA. Dynamics of brain metabolism and gene expression after middle cerebral artery occlusion in mice. J. Cereb. Blood Flow Metab. 2000; 20: 306-315. doi: 10.1097/00004647-200002000-00012
25. Hata R, Maeda K, Hermann DM, Mies G, Hossmann KA. Evolution of brain infarction after transient focal cerebral ischemia in mice. J. Cereb. Blood Flow Metab. 2000; 20: 937-946.
26. Kuroiwa T, Ito U, Hakamata Y, Hanyu S, Mies G, Hermann D. Evolution of energy failure after repeated cerebral ischemia in gerbils. Acta Neurochir. 2000; 76: 43-46.
27. Hermann DM, Kuroiwa T, Hata R, Gillardon F, Ito U, Mies G. Expression of nuclear redox factor-1, p53-activated gene 608 and caspase-3 messenger RNAs following repeated unilateral common carotid artery occlusion in gerbils - Relationship to delayed cell injury and secondary failure of energy state. Neuroscience. 2001; 102: 779-787.
28. Hermann DM, Kilic E, Hata R, Hossmann KA, Mies G. Relationship between metabolic changes, gene responses and delayed cell death after mild focal cerebral ischemia in mice. Neuroscience. 2001; 102: 947-955.
29. Hermann DM, Kilic E, Kgler S, Isenmann S, Bähr M. Adenovirus-mediated GDNF and CNTF pretreatment protects against striatal injury following transient middle cerebral artery occlusion in mice. Neurobiol. Dis. 2001; 8:655-666.
30. Hermann DM, Kilic E, Kgler S, Isenmann S, Bähr M. Adenovirus-mediated glial cell line-derived neurotrophic factor GDNF expression protects against subsequent cortical cold injury in rats. Neurobiol. Dis. 2001; 8: 964-973.
31. Kilic E, Bähr M, Hermann DM. Effects of recombinant tissue-plasminogen activator after intraluminal thread occlusion in mice: Role of hemodynamic alterations. Stroke. 2001; 32: 2641-2647. doi: 10.1161/hs1101.097381
32. Kilic E, Hermann DM, Isenmann S, Bähr M. Effects of pinealectomy and melatonin on the retrograde degeneration of retinal ganglion cells in a novel model of intraorbital optic nerve transection in mice. J. Pineal Res. 2002; 32: 106-111. doi: 10.1034/j.1600-079x.2002.1823.x
33. Kilic E, Dietz G, Hermann DM, Bähr M. Intravenous TAT-Bcl-XL is protective after middle cerebral artery occlusion in mice. Ann. Neurol. 2002; 52; 617-622. doi: 10.1002/ana.10356
34. Kilic E, Hermann DM, Kgler S, Bähr M. Adenovirus-mediated Bcl-XL expression using a neuron-specific synapsin-1 promoter protects against disseminated neuronal injury and brain infarction following focal cerebral ischemia in mice. Neurobiol. Dis. 2002; 11: 275-284.
35. Hermann DM, Mies G, Hossmann KA. Expression of c-jun, mkp-1, caspase-3 and gfap mRNAs following cortical cold trauma in rats: Relationship to brain metabolism and delayed cell injury. Neuroscience. 2004; 123: 371-379.
36. Kilic E, Bassetti CL, Hermann DM. Recombinant tissue-plasminogen activator t-PA attenuates disseminate neuronal injury after mild episodes of middle cerebral artery MCA thread occlusion in mice. Neuroreport. 2004; 15: 687-689.
37. Kilic E, Yulug B, Hermann DM, Reiter RJ. Melatonin delivery reduces disseminate neuronal death after mild focal ischemia in C57BL/6j mice via inhibition of caspase-3 and is suitable as add-on treatment to tissue-plasminogen activator. J. Pineal Res. 2004; 36: 171-176.
38. Kilic E, Reiter RJ, Bassetti CL, Hermann DM. Prophylactic melatonin protects against focal cerebral ischemia in mice: Role of endothelin converting enzyme-1. J. Pineal Res. 2004; 37: 247-251. doi: 10.1111/j.1600-079X.2004.00162.x
39. Spaeth N, Wyss MT, Weber B, et al.Uptake of 18F-fluorocholine, 18F-fluoro-ethyl-L-tyrosine and 18F-fluoro-2-deoxyglucose in acute cerebral radiation injury in the rat: implications for the separation of radiation necrosis from tumor recurrence. J. Nucl. Med. 2004; 45:1931-1938.
40. Kilic E, Weishaupt J, Rohde G, et al. The superoxide dismutase1 SOD1 G93A mutation does not promote neuronal injury after transient focal brain ischemia und optic nerve transection in mice. Neuroscience. 2004; 128: 359-364.
41. Kilic E, Reiter RJ, Bassetti C, Hermann DM. Signal transduction pathways involved in melatonin-induced neuroprotection after focal cerebral ischemia in mice. J. Pineal Res. 2005; 38: 67-71. doi: 10.1111/j.1600-079X.2004.00178.x
42. Hermann DM, Bassetti C. Reversible opsoclonus following diphenhydramine misuse. Eur. Neurol. 2005; 53: 46-47. doi: 10.1159/000084266
43. Hermann DM, Fehr J, Bassetti C. Epstein Barr virus EBV associated T cell clonopathy mimicking lymphomatous meningitis. J. Neurol. 2005; 252: 736-737.
44. Kilic E, Matter C, Lscher TF, Bassetti C, Hermann DM. Aggravation of focal cerebral ischemia by tissue-plasminogen activator is reversed by HMG CoA reductase inhibitor, but does not depend on endothelial NO synthase. Stroke. 2005; 36: 332-336.
45, Kilic E, Soliz J, Bassetti C, Gassmann M, Hermann DM. Transgenic erythropoietin protects from axotomy-induced degeneration of retinal ganglion cells by activating ERK-1/-2. FASEB J. 2005; 19: 249-251.
46. Wang Y, Kilic E, Weber B, Bassetti C, Marti H, Hermann DM. VEGF overexpression induces post-ischaemic neuroprotection, but facilitates haemodynamic steal phenomena. Brain. 2005; 128: 52-63. doi: http://dx.doi.org/10.1093/brain/awh325
47. Kilic E, Reiter RJ, Bassetti CL, Hermann DM. Melatonin reverses t-PA-induced brain injury after intraluminal middle cerebral artery occlusion in mice: Role of Akt and inducible NO synthase. J. Pineal Res. 2005; 39: 151-155.
48. Kilic, Bassetti C, Kilic E, Xing H, Wang Z, Hermann DM. Post-ischemic delivery of the HMG-CoA reductase inhibitor rosuvastatin protects against focal cerebral ischemia in mice by mechanisms involving inhibition of extracellular-regulated kinase ERK-1/-2. Neuroscience. 2005; 106: 901-906.
49. Spudich A, Frigg R, Kilic E, B. et al. Aggravation of ischemic injury by prion protein deficiency following focal cerebral ischemia in mice: Role of ERK-1/-2 and STAT-1. Neurobiol. Dis. 2005; 20: 442-449.
50. Kilic E, Soliz J, Bassetti C, Gassmann M, Hermann DM. Erythropoietin protects from focal cerebral ischemia by a dual mechanism involving both ERK-1/-2 and Akt pathways. FASEB J. 2005; 19: 2026-2028.
51. Selic C, Siccoli MM, Hermann DM, Bassetti C. Blood pressure evolution after acute ischemic stroke in patients with and without sleep apnea. Stroke. 2005; 36: 2614-2618. doi: 10.1161/01.STR.0000189689.65734.a3
52. Kilic E, Bähr M, Hermann DM. Aggravation of focal cerebral ischemia by tissue-plasminogen activator is reversed by MK-801. Neurodegen. Dis. 2005; 2: 49-55.
53. Kilic E, Hermann DM. TAT-GDNF in neurodegenerative disease and ischemic stroke. CNS Drug Rev. 2005; 11: 353-362.
54. Spudich A, Kilic E, Xing H, Wunderli-Allenspach H, Bassetti CL, Hermann DM. Pharmacological inhibition of multidrug resistance transporter Mdr-1 facilitates neuroprotective therapies after focal cerebral ischemia. Nature Neurosci. 2006; 9: 487-488.
55. Kilic E, Wang Y, Bassetti C, Marti H, Hermann DM. The phosphatidylinositol-3 kinase/ Akt mediates VEGF s neuroprotective activity and induces blood brain barrier disturbance after focal cerebral ischemia. FASEB J. 2006; 20: 1185-1187. doi: 10.1096/fj.05-4829fje
56. Matter CM, Ma L, Von Lukovicz T, et al. Increased balloon-induced neointima in apolipoprotein E ApoE knockout mice - incremental effects of the ApoE gene and high-cholesterol diet. Stroke. 2006; 37: 2625-2632. doi: 10.1161/01.STR.0000241068.50156.82
57. Baumann CR, Kilic E, Werth E, Hermann DM, Tafti M, Bassetti C. Sustained non-rapid eye movement NREM sleep increase following striatal but not cortical middle cerebral artery infarcts in mice. Sleep. 2006; 29: 1339-1344.
58. Kilic E, Wang Y, Bassetti C, Marti H, Hermann DM. Transgenic VEGF protects from axotomy-induced degeneration of retinal ganglion cells by activating ERK-1/-2 and Akt pathways. J. Neurosci. 2006; 26: 12439-12446.
59. Hermann DM, Siccoli M, Kirov P, Gugger M, Bassetti C. Central periodic breathing during sleep in acute ischemic stroke. Stroke. 2007; 38: 1082-1084.
60. Soliz J, Soulage C, Hermann DM, Gassmann M. Acute and chronic exposure to hypoxia alters ventilatory pattern but not minute ventilation of mice overexpressing erythropoietin. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2007; 293: R1702-R1710.
61. Kilic E, Wippel A, Vogel P, et al. Poxvirus-derived cytokine response modifier A CrmA does not protect against focal cerebral ischemia in mice. Brain Res. 2007; 1185: 293-300. doi:
62. Hermann DM, Siccoli M, Wachter k, Mathis J, Achermann P, Bassetti C. Evolution of neurological, neuropsychological and sleep-wake disturbances in paramedian thalamic stroke. Stroke. 2008; 39: 62-68. doi: 10.1161/STROKEAHA.107.494955
63. Kilic E, Bacigaluppi M, Guo Z, et al. Delayed melatonin administration promotes neuronal survival, neurogenesis and motor recovery, and attenuates hyperactivity and anxiety after mild focal cerebral ischemia in mice. J. Pineal Res. 2008; 45: 142-148. doi: 10.1111/j.1600-079X.2008.00568.x
64. Hédou GF, Koshibu K, Farinelli M, et al. Protein phosphatase 1-dependent bidirectional synaptic plasticity controls ischemic recovery in the adult brain. J. Neurosci. 2008; 28: 154-162. doi: 10.1523/JNEUROSCI.4109-07.2008
65. Gao B, Kilic E, Baumann C, Hermann DM, Bassetti C. Gamma-hydroxybutyrate accelerates functional recovery after focal cerebral ischemia. Cerebrovasc. Dis. 2008; 26: 413-419. doi: 10.1159/000151683
66. Kilic E, Bassetti CL, Hermann DM. TLR-4 deficiency protects against focal cerebral ischemia and delayed neurodegeneration. Neurobiol. Dis. 2008; 31: 33-40.
67. Kilic E, Spudich A, Rentsch KM, et al. ABCC1: A gateway for pharmacological compounds to the ischaemic brain. Brain. 2008; 131: 2679-2689. doi: 10.1093/brain/awn222
68. Hermann DM, Barth A, Porchet F, Hess CW, Mumenthaler M, Bassetti C. Nocturnal positional lumboischialgia: Presenting symptom of lumbar spinal tumors. J. Neurol. 2008; 255: 1836-1837. doi: 10.1007/s00415-008-0998-0
69. Siccoli MM, Valko PO, Hermann DM, Bassetti C. Central periodic breathing during sleep in 74 patients with acute ischemic stroke - Neurogenic and cardiogenic factors. J. Neurol. 2008; 255: 1687-1692. doi: 10.1007/s00415-008-0981-9
70. Hermann DM, Jung HH, Bassetti C. Lateral medullary infarct with alternating and dissociated sensorimotor symptoms: Opalski s syndrome revisited. Eur. J. Neurol. 2009; 16: e72-e74.
71. Bacigaluppi M, Pluchino S, Kilic E, et al. Delayed systemic neural stem cell transplantation protects from ischemic brain injury via multiple mechanisms. Brain. 2009; 132(8): 2239-2251.
72. Kilic E, ElAli A, Bassetti C, Guo Z, Schwab ME, Hermann DM. Role of Nogo-A in neuronal survival in the reperfused ischemic brain. J. Cereb. Blood Flow Metab. 2010; 30: 969-984. doi: 10.1038/jcbfm.2009.268.
73. Zechariah A, ElAli A, Hermann DM. Combination of tissue-plasminogen activator with erythropoietin induces blood-brain barrier permeability, extracellular matrix disaggregation and DNA fragmentation after focal cerebral ischemia in mice. Stroke. 2010; 41: 1008-1012.
74. ElAli A, Hermann DM. Apolipoprotein E controls ATP-binding cassette transporters in the ischemic brain. Sci. Signal. 2010: 3: 72.
75. Doeppner TR, Kaltwasser B, ElAli A, Zechariah A, Hermann DM, Bähr M. Acute hepatocyte growth factor treatment induces long-term neuroprotection and stroke recovery via mechanisms involving neural precursor cell proliferation and differentiation. J. Cereb. Blood Flow Metab. 2011; 31: 1251-1262. doi: 10.1038/jcbfm.2010.211
76. Reitmeir R, Kilic E, Bacigaluppi M, et al. Post-acute delivery of erythropoietin induces stroke recovery by promoting peri-lesional tissue remodeling and contralesional pyramidal tract plasticity. Brain. 2011; 134: 84-99. doi: 10.1093/brain/awq344
77. ElAli A, Hermann DM. Liver X receptor activation enhances blood-brain barrier integrity in the ischemic brain and increases the abundance of ATP-binding cassette transporters ABCB1 and ABCC1 on brain capillary cells. Brain Pathol. 2012; 22: 175-187. doi: 10.1111/j.1750-3639.2011.00517.x
78. Hermann DM, Keyvani K, Van de Nes J, et al. Brain-reactive β-amyloid antibodies in primary CNS angiitis with cerebral amyloid angiopathy. Neurology. 2011; 77: 503-505. doi: 10.1212/WNL.0b013e318227b250
79. Doeppner TR, Bretschneider E, Doehring M, et al. Enhancement of endogenous neurogenesis in ephrin-B3 deficient mice after transient focal cerebral ischemia. Acta Neuropathol. 2011; 122: 429-442. doi: 10.1007/s00401-011-0856-5
80. ElAli A, Doeppner TR, Zechariah A, Hermann DM. Increased blood-brain barrier permeability and brain edema after focal cerebral ischemia induced by hyperlipidemia: Role of lipid peroxidation and calpain-1/2, matrix metalloproteinase-2/9, and RhoA overactivation. Stroke. 2011; 42: 3238-3244. doi: 10.1161/STROKEAHA.111.615559.
81. Kilic U, Yilmaz B, Ugur M, et al. Evidence that membrane-bound G protein-coupled melatonin receptors MT1 and MT2 are not involved in the neuroprotective effects of melatonin in focal cerebral ischemia. J. Pineal Res. 2012; 52: 228-235. doi: 10.1111/j.1600-079X.2011.00932.x
82. Patak P, Jin F, Schafer ST, Metzen E, Hermann DM. The ATP-binding cassette transporters ABCB1 and ABCC1 are not regulated by hypoxia in immortalised human brain microvascular endothelial cells. Exp. Transl. Stroke Med. 2011; 3: 12. doi: 10.1186/2040-7378-3-12
83. Reitmeir R, Kilic E, Reinboth BS, ElAli A, Zechariah A, Hermann DM. Vascular endothelial growth factor induces contralesional corticobulbar plasticity and functional neurological recovery in the ischemic brain. Acta Neuropathol. 2012; 123: 273-284.
84. Hasan MR, Herz J, Hermann DM, Doeppner TR. Visualization of macroscopic cerebral vessel anatomy - a new and reliable technique in mice. J. Neurosci. Meth. 2012; 204: 249-253. doi: 10.1016/j.jneumeth.2011.11.024.
85. Herz J, Reitmeir R, Hagen SI, et al. Intracerebroventricularly delivered VEGF promotes contralesional corticorubral plasticity after focal cerebral ischemia via mechanisms involving anti-inflammatory actions. Neurobiol. Dis. 2012; 45: 1077-1085. doi: 10.1016/j.nbd.2011.12.026
86. ElAli A, Urrutia A, Colado MI, Hermann DM. Apolipoprotein-E controls ATP-binding cassette transporters ABCB1 and ABCC1 on cerebral microvessels after methamphetamine intoxication. Stroke. 2012; 43: 1647-1653. doi: 10.1161/STROKEAHA.111.648923
87. Herring A, Donath A, Steiner KM, et al. Reelin depletion is an early phenomenon of Alzheimer s pathology. J. Alzheimer s Dis. 2012; 30: 963-979. doi: 10.3233/JAD-2012-112069
88. Doeppner TR, Ewert TAS, Herz J, et al. Transduction of neural precursor cells with TAT-Hsp70 chaperone: therapeutic potential against ischemic stroke after intrastriatal and systemic transplantation. Stem Cells. 2012; 30: 1297-1310. doi: 10.1002/stem.1098
89. Hermann DM, Gronewold J, Lehmann N, et al. Intima-media thickness predicts stroke risk in the Heinz Nixdorf Recall study in association with vascular risk factors, age and gender. Atherosclerosis. 2012; 224: 84-89.
90. Doeppner TR, Mlynarczuk-Bialy I, Kuckelkorn U, et al. The novel proteasome inhibitor BSc2118 protects against focal cerebral ischemia and promotes blood-brain-barrier integrity via HIF-1α accumulation and enhanced angioneurogenesis. Brain. 2012; 135: 3282-3297.
91. Jin F, Ji H, Jia C, et al. Synergistic antitumor effects of endostar in combination with oxaliplatin via inhibition of HIF and CXCR4 in the colorectal cell line SW1116. PLoS One. 2012; 7: e47161. doi: 10.1371/journal.pone.0047161
92. Urrutia A, Rubio-Araiz A, Gutierrez-Lopez MD, et al. A study on the effect of JNK inhibitor, SP600125, on the disruption of blood-brain barrier induced by methamphetamine. Neurobiol. Dis. 2013; 50: 49-58. doi: 10.1016/j.nbd.2012.10.006
93. Hermann DM, Gronewold J, et al. Coronary artery calcification is an independent stroke predictor in the general population. Stroke. 2013; 44: 1008-1013. doi: 10.1161/STROKEAHA.111.678078
94. Zechariah A, ElAli A, Doeppner TR, et al. VEGF promotes pericyte coverage of brain capillaries, improves cerebral blood flow during subsequent focal cerebral ischemia, and preserves the metabolic penumbra. Stroke. 2013; 44: 1690-1697. doi: 10.1161/STROKEAHA.111.000240
95. Zechariah A, ElAli A, Hagemann N, et al. Hyperlipidemia attenuates VEGF-induced angiogenesis, impairs cerebral blood flow and disturbs stroke recovery via reduced VEGF receptor-2 and -1 expression and decreased pericyte coverage of brain endothelial cells. Arterioscler. Thromb. Vasc. Biol. 2013; 33: 1561-1567.
96. Jin F, Hagemann N, Brockmeier U, Schäfer ST, Zechariah A, Hermann DM. LDL attenuates VEGF-induced angiogenesis via mechanisms involving VEGFR2 internalization and degradation following endosome-trans-Golgi network trafficking. Angiogenesis. 2013; 16: 625-637. doi: 10.1007/s10456-013-9340-2
97. Hasan MR, Herz J, Hermann DM, Doeppner TR. Intravascular perfusion of carbon black ink allows reliable visualization of cerebral vessels. J. Vis. Exp. 2013; 71. doi: 10.3791/4374
98. Seidel UK, Gronewold J, Volsek M, et al. The prevalence, severity, and association with HbA1c and fibrinogen of cognitive impairment in chronic kidney disease. Kidney Int. 2014; 85: 693-702.
99. Jin F, Hagemann N, Schäfer ST, Brockmeier U, Zechariah A, Hermann DM. SDF-1 restores angiogenesis synergistically with VEGF following LDL exposure: Role of CXCR4 internalization and degradation. Cardiovasc. Res. 2013; 100: 481-491. doi: 10.1093/cvr/cvt209.
100. Doeppner TR, Doehring M, Bretschneider E, et al. MicroRNA-124 protects against focal cerebral ischemia via mechanisms involving Usp14-dependent REST degradation. Acta Neuropathol. 2013; 126: 251-265. doi: 10.1007/s00401-013-1142-5
101. Doeppner TR, Kaltwasser B, Fengyan J, Hermann DM, Bähr M. TAT-Hsp70 induces neuroprotection against stroke via anti-inflammatory actions providing appropriate cellular microenvironment for transplantation of neural precursor cells. J Cereb Blood Flow Metab. 2013; 33: 1778-1788. doi: 10.1038/jcbfm.2013.126
102. Goebel S, Li Z, Vogelmann J, et al. The GPVI-Fc fusion protein Revacept improves cerebral infarct volume and functional outcome in stroke. PLoS One. 2013; 8: e66960. doi: 10.1371/journal.pone.0066960
103. Herz J, Hagen SI, Bergmller E, et al. Exacerbation of ischemic brain injury in hypercholesterolemic mice is associated with pronounced changes in peripheral and cerebral immune responses. Neurobiol Dis. 2014; 62: 456-468. doi: 10.1016/j.nbd.2013.10.022
104. Hoyo-Becerra C, Huebener A, Trippler M, et al. Concomitant interferon alpha stimulation and TLR3 activation induces neuronal expression of depression-related genes that are elevated in the brain of suicidal persons. PLoS One. 2013; 8: e83149. doi: 10.1371/journal.pone.0083149
105. Gronewold J, Hermann DM, Lehmann N, et al. Ankle-brachial index is an independent stroke predictor in the general population.Atherosclerosis. 2014; 233: 545-550. doi: http://dx.doi.org/10.1016/j.atherosclerosis.2014.01.044
106. Kara K, Gronewold J, Neumann T, et al. B-type natriuretic peptide predicts stroke of presumable cardioembolic origin in addition to coronary artery calcification.Eur J Neurol. 2014; 21: 914-921. doi: 10.1111/ene.12411
107. Seidel UK, Gronewold J, Volsek M, et al. Physical, cognitive and emotional factors contributing to quality of life, functional health and participation in community dwelling in chronic kidney disease.PLoS One. 2014; 9: e91176. doi: 10.1371/journal.pone.0091176
108. Tang WK, Hermann DM, Chen YK, et al. Brainstem infarcts predict REM sleep behavior disorder in acute ischemic stroke. BMC Neurol. 2014; 14: 88. doi: 10.1186/1471-2377-14-88
109. Gronewold J, Bauer M, Lehmann N, et al. Coronary artery calcification, intima-media thickness, and ankle-brachial index are complementary stroke predictors. Stroke. 2014; 45: 2702-2709. doi: 10.1161/STROKEAHA.114.005626
110. Doeppner TR, Kaltwasser B, Teli MK, Bretschneider E, Bähr M, Hermann DM. Effects of acute versus post-acute systemic delivery of neural progenitor cells on neurological recovery and brain remodeling after focal cerebral ischemia in mice. Cell Death Dis. 2014; 5: e1386. doi: 10.1038/cddis.2014.359
111. Hoyo-Becerra C, Liu Z, Yao J, et al. Rapid regulation of depression-associated genes in a new mouse model mimicking interferon-α-related depression in hepatitis C virus infection. Mol Neurobiol. 2014. doi: 10.1007/s12035-014-8861-z
112. Doeppner TR, Kaltwasser B, Bähr M, Hermann DM. Effects of neural progenitor cells on post-stroke neurological impairment-a detailed and comprehensive analysis of behavioral tests. Front Cell Neurosci. 2014; 8: 338.
113. Neumann J, Riek-Burchardt M, Herz J, et al. Very-late-antigen-4 VLA-4-mediated brain invasion by neutrophils leads to interactions with microglia, increased ischemic injury and impaired behavior in experimental stroke. Acta Neuropathol. 2014. doi: 10.1007/s00401-014-1355-2
114. Kilic E, Reitmeir R, Kilic, et al. HMG-CoA reductase inhibition promotes neurological recovery, perilesional tissue remodeling and contralesional pyramidal tract plasticity after focal cerebral ischemia. Front Cell Neurosci. 2014.
115. Hermann DM, Lehmann N, Gronewold J, et al. Thoracic aortic calcification is associated with incident stroke in the general population in addition to established risk factors. Eur Heart J Cardiovasc Imag. 2014.
116. Bacigaluppi M, Russo GL, Peruzzotti-Jametti L, et al. Neural stem cell transplantation promotes post-ischemic recovery through the glutamate transporter GLT1. J Clin Invest. 2014.


REVIEW ARTICLES


1. Hermann DM, Hossmann KA. Neurological effects of microwave exposure related to mobile communication. J. Neurol. Sci. 1997; 152: 1-14. doi: http://dx.doi.org/10.1016/S0022-510X(97)00140-8
2. Hermann DM, Bassetti C. Cerebral circulation and sleep. Sleep Med. Rev. 2002; 6: 425-427.
3. Hossmann KA, Hermann DM. Effects of electromagnetic radiation of mobile phones on the central nervous system. Bioelectromagnetics. 2003; 24: 49-62. doi: 10.1002/bem.10068
4. Hermann DM, Bassetti C. Sleep-disordered breathing and stroke. Curr. Opin. Neurol. 2003; 16: 87-90.
5. Hermann DM, Bassetti C. Sleep apnea and other sleep disorders in stroke. Curr. Treatm. Opt. Neurol. 2003; 5: 241-249.
6. Hermann DM, Siccoli M, Bassetti C. Sleep-wake disorders and stroke. Swiss Arch. Neurol. Psychiatr. 2003; 154: 369-374.
7. Kilic E, Hermann DM. TAT fusion proteins against ischemic stroke: Current status and future perspectives. Frontiers Biosci. 2006; 11: 1716-1721.
8. Grimm C, Hermann DM, Bogdanova A, et al. Neuroprotection by hypoxic preconditioning: HIF-1 and erythropoietin protect from retinal degeneration. Sem. Cell Dev. Biol. 2005; 16: 531-538.
9. Bassetti CL, Hermann DM. Foramen ovale closure: Feasible, but usually not necessary. Swiss Arch. Neurol. Psychiatr. 2006; 157: 180-183.
10. Hermann DM, Kilic E, Spudich A, Krämer SD, Wunderli H, Bassetti CL. Role of drug efflux carriers in the healthy and diseased brain. Ann. Neurol. 2006; 60: 489-498. doi: 10.1002/ana.21012
11. Hermann DM, Bassetti CL. Implications of ATP binding cassette transporters for brain pharmacotherapies. Trends Pharmacol. Sci. 2007; 28: 128-134.
12. Bacigaluppi M, Pluchino S, Kilic E, Martino G, Hermann DM. Neural precursor cells in the treatment of ischemic stroke. J. Neurol. Sci. 2007; 265: 73-77.
13. Siekierka-Kleiser EM, Eng K, Bassetti C, et al. New technologies and concepts for rehabilitation in the acute phase of stroke: A collaborative matrix. Neurodegen. Dis. 2007; 4: 57-69.
14. Hermann DM. Biodistribution processes as underestimated confounders in translational stroke research. Curr. Med. Chem. 2007; 14: 3179-3184.
15. Hermann DM, Matter CM. Tissue-plasminogen activator-induced reperfusion injury after stroke revisited. Circulation. 2007; 116: 363-365. doi: 10.1161/CIRCULATIONAHA.107.712380
16. Hermann DM, Bassetti C. Neuroprotection in the SAINT-II aftermath. Ann. Neurol. 2007; 62: 677-678. doi: 10.1002/ana.21210
17. Bacigaluppi M, Hermann DM. New targets of neuroprotection in ischemic stroke. Scientific World Jounal. 2008; 8: 698-712. doi: 10.1100/tsw.2008.94
18. Hermann DM. Future perspectives for brain pharmacotherapies: implications of drug transport processes at the blood-brain barrier. Ther. Adv. Neurol. Dis. 2008; 1: 167-181. doi: 10.1177/1756285608097775
19. Ennen JC, Mueller B, Bibl M, et al. Influence of multimodal physical activity on cognition and life skills in sooner Alzheimer s dementia SPORTS & KOG. Gerontopsychologie. 2008; 21: 163-169.
20. Hermann DM, Kilic E. Therapeutic potential and possible risk of pleiotropic growth factors in ischemic stroke. Stroke. 2008; 39: e182. doi: 10.1161/STROKEAHA.108.532374
21. Hermann DM. Blur in the projectability: The stroke numbers by half the 205th Dt. Medical Journal. 2008; 105: 844.
22. Hermann DM. Enhancing erythropoietin delivery to the ischemic brain. Scientific World Journal. 2009; 9: 967-969. doi: 10.1100/tsw.2009.104
23. Zechariah A, Hermann DM. Implications of vascular endothelial growth factor for postischemic neurovascular remodelling. J. Cereb. Blood Flow Metab. 2009; 29: 1620-1643. doi: 10.1038/jcbfm.2009.100
24. Hermann DM, Bassetti C. Sleep-related breathing and sleep-wake disturbances in ischemic stroke. Neurology. 2009; 73: 1313-1322. doi: 10.1212/WNL.0b013e3181bd137c
25. Bacigaluppi M, Comi G, Hermann DM. Animal models of ischemic stroke - Part 1: Models for risk factors. Open Neurology Journal. 2010; 4: 26-33.
26. Bacigaluppi M, Comi G, Hermann DM. Animal models of ischemic stroke - Part 2: Models of cerebral ischemia. Open Neurology Journal. 2010; 4: 34-38.
27. Hermann DM. Nonhematopoietic variants of erythropoietin in ischemic stroke: need for step-wise proof-of-concept studies. Scientific World Journal. 2010; 10: 2285-2287. doi: 10.1100/tsw.2010.226
28. Hermann DM. Neuroprotective und neurorestoration: Ready for translation to clinics? Swiss Arch. Neurol. Psychiatry. 2010; 161: 274-275.
29. Hermann DM. Neues zur Alzheimer-Demenz. Akt. Neurol. 2010; 37: 274-278.
30. Doeppner TR, Hermann DM. Free radical scavengers and spin traps - therapeutic implications for ischemic stroke. Best Pract. Res. Clin. Anaesth. 2010; 24: 511-520. doi: 10.1016/j.bpa.2010.10.003
31. Doeppner TR, Hermann DM. Mesenchymal stem cells in the treatment of ischemic stroke: progress and possibilities. Stem Cells Clon. 2010 3: 157-163. doi: http://dx.doi.org/10.2147/SCCAA.S7820
32. Hermann DM, Van Hook MA. Bringing drugs into the brain and keeping them there. Sci. Signal. 2010; 3142: 18.
33. ElAli A, Hermann DM. ATP-binding cassette transporters and their roles in protecting the brain. Neuroscientist. 2011; 17: 423-436. doi: 10.1177/1073858410391270.
34. Bassetti CL, Hermann DM. Sleep and stroke. Hand b. Clin. Neurol. 2011; 99: 1051-1072.
35. Hermann DM, Patak P. Bringing drugs into the brain and keeping them there Editorial. In: Hermann DM, Patak P, eds. Curr. Pharm. Dis. 2011; 17: 2787-2792.
36. Patak P, Hermann DM. ATP-binding cassette transporters at the blood-brain barrier in ischaemic stroke. Special issue: Bringing drugs into the brain and keeping them there. In: Hermann DM, Patak P, eds. Curr. Pharm. Dis. 2011; 17: 2748-2749.
37. Hermann DM, Chopp M. Promoting brain plasticity and remodeling for stroke recovery: Therapeutic potential, caveats and consequences for clinical translation. Lancet Neurol. 2012; 11, 369-380. doi: 10.1016/S1474-4422(12)70039-X
38. Ma Y, Zechariah A, Qu Y, Hermann DM. Effects of vascular endothelial growth factor in ischemic stroke. J. Neurosci. Res. 2012; 90: 1873-1882. doi: 10.1002/jnr.23088
39. Hermann DM, ElAli A. The abluminal endothelial membrane in neurovascular remodeling in health and disease. Sci. Signal. 2012; 5. doi: 10.1126/scisignal.2002886
40 Hermann DM, Grotz W. Cognitive impairment in chronic kidney disease. nephrologist. 2013; 8: 323-326.
41. Hermann DM, Nagel E. The dementia patient in hospital Zeitschrift medicine. ethics, law. 2013; 2: 36-41.
42. Hermann DM, Buga AM, Popa-Wagner A. Enabling brain plasticity and neurological recovery in the ischemic brain: effect of age and vascular risk factors as confounders. Rom J Morphol Embryol. 2013; 54: 3-6.
43. Hermann DM. Challenging current views on apolipoprotein-E s role as stroke predictor. Eur J Neurol. 2014; 21: 1051-1052. doi: 10.1111/ene.12377
44. Hermann DM, Buga AM, Popa-Wagner A. Neurovascular remodeling in the aged ischemic brain. J Neural Transm. 2013. doi: 10.1007/s00702-013-1148-0
45. Hermann DM, Kribben A, Bruck H. Cognitive impairment in chronic kidney disease: Neuroimaging findings, risk factors and consequences for patient care. J Neural Transm. 2014; 121: 627-632. doi: 10.1007/s00702-014-1160-z
46. Seidel UK, Gronewold J, Kribben MA, Bruck H, Hermann DM. Response to: Cognitive function over time in patients on chronic hemodialysis. Kidney Int. 2014; 85: 713.
47. Hermann DM. Alzheimer dementia: why therapy comes too late.MMW Fortschr Med. 2014; 1562: 36.
48. Hermann DM. Vitamin E delays the progression of Alzheimer s also only slightly. MMW Fortschr Med. 2014; 15611: 36.
49. Hermann DM, Muck S, Nehen HG. Supporting dementia patients in hospital environments: health-related risks, needs and dedicated structures for patient care. Eur J Neurol. 2014. doi: 10.1111/ene.12530
50. Nehen HG, Hermann DM. Supporting dementia patients and their caregivers in daily life challenges: review of physical, cognitive and psychosocial intervention studies. Eur J Neurol. 2014. doi: 10.1111/ene.12535
51. Hoyo-Becerra C, Schlaak JF, Hermann DM. Insights from interferon-α-related depression for the pathogenesis of depression associated with inflammation. Brain Behav Immun. 2014; 42C: 222-231. doi: 10.1016/j.bbi.2014.06.200
52. Hermann DM, Chopp M. Promoting neurological recovery in the post-acute stroke phase: benefits and challenges. Eur Neurol. 2014; 72: 317-325. doi: 10.1159/000365171
53. Hermann DM, Peruzzotti-Jametti L, Schlechter J, Bernstock JD, Doeppner TR, Pluchino S. Neural precursor cells in the ischemic brain - integration, cellular crosstalk, and consequences for stroke recovery. Front Cell Neurosci. 2014; 8: 291.
54. Popa-Wagner A, Buga AM, Doeppner TR, Hermann DM. Stem cell therapies in preclinical models of stroke associated with aging. Front Cell Neurosci. 2014; 8: 347.
55. Doeppner TR, Hermann DM. Stem cell-based treatments against stroke: observations from human proof-of-concept studies and considerations regarding clinical applicability. Front Cell Neurosci. 2014; 8: 357.


BOOK CHAPTERS


1. Hermann DM, Hincke P, Luppi PH, Jouvet M. Afferents to the nucleus raphe magnus demonstrated by iontophoretic application of unconjugated cholera toxin b in rats and guinea-pigs. Integrative and Cellular Aspects of Autonomic Functions: Temperature- and Osmoregulation. In: Pleschka K, Gerstberger R, eds. Verlag John Libbey, Strasbourg. 1994; 243-252.
2. Hermann DM, Hincke P, Luppi PH, Jouvet M. Functional neuroanatomical considerations on afferent and efferent connections of the nucleus raphe magnus. Thermal Balance in Health and Disease. In: Zeisberger E, Schönbaum E, Lomax P, eds. Birkhäuser Verlag, Basel, Boston, Berlin. 1994; 79-84.
3. Pollmächer T, Mullington J, Hinze-Selch D, Orth A, Hermann DM, Holsboer F. The influence of experimental stimulation of the primary host response to human sleep. Contributions to. Congress of the Society for Biological Psychiatry. 1995.
4. Hermann DM, Mullington J, Korth C, Pollmächer T. Morning endotoxin leads to foothill before suppression of NREM sleep Direction in G-CSF-pretreated subjects Sleep Research. Mnchener medical publishing MMW. 1994; 129-131.
5. Hermann DM. Afferente und efferente Raphe magnus and projections of the nuclei under pallidus Bercksichtigung thermal adaptation. Inaugural dissertation leading to a doctoral degree in medicine, Faculty of Medicine, University of Giessen. 1995.
6. Hermann DM, Mies G, Hossmann KA. Metabolic disturbances and gene responses following cortical injury in rats: Relationship to spreading depression. Maturation Phenomenon in Cerebral Ischemia: Defensive Mechanisms versus Apoptosis. In: Fieschi C, Ito U, Orzi F, Kuroiwa T, Klatzo I. 1999; 183-192.
7. Hossmann KA, Hermann DM. Health aspects of mobile communication: Risks to the central nervous system. Electricity and Magnetism in Biology and Medicine. In: Bersani F, Kluwer Academic / Plenum Publishers. 1999; 37-41.
8. Mies G, Trapp T, Kilic E, Oláh L, et al. Relationship between DNA fragmentation, energy state, and protein synthesis after transient focal cerebral ischemia in mice. Maturation Phenomenon in Cerebral Ischemia IV, Defensive mechanisms versus apoptosis, recovery, and protection in cerebral ischemia. Bazan N, Ito U, Kuroiwa T. Springer-Verlag, Berlin, Heidelberg. 2001; 85-92.
9. Hermann DM. Secondary damage development and neuroprotective therapy in focal ischemia and traumatic Kortexläsion. Habilitation Thesis Faculty of Medicine, Eberhard-Karls-University Tbingen. 2002.
10. Hermann DM, Bassetti C. Transient ischemic attack and ischemic stroke Cardix 2005. In: Lscher TF, Schwegler PR. Zrich AG. 2005; 71-77.
11. Hermann DM, Bassetti C. Sleep disorders after stroke In: Recovery after stroke. Bogousslavsky J, Dobkin B, Barnes M. Cambridge University Press, Cambridge. 2005; 580-603.
12. Hermann DM, Bassetti C. Transient ischemic attack and ischemic stroke Cardix of 2007. In: Lscher TF, Schwegler PR, Zrich AG, eds. 2007; 83-89.
13. Hermann DM. Biodistribution processes: Underestimated confounders in neuroprotective drug development. Brain Hypoxia Ischemia Research Progress. In: Columbus F, Novapublishers, New York. 2008.
14. Hermann DM, Bassetti C. Transient ischemic attack and ischemic stroke Cardix of 2009. In: Lscher TF, Schwegler PR, Zrich AG, eds. 2009.
15. Hermann DM, Bassetti C. Transient ischemic attack and ischemic stroke. Cardix 2009 engl. In: Lscher TF, Schwegler PR, Zrich AG, eds. 2009.
16. Hermann DM, Bassetti C. Sleep disorders and stroke: Causes and consequences In: Sleep Disorders in Neurological Disease: a Practical Approach. . Overeem S,Reading P, eds. Wiley-Blackwell, New York. 2010.
17. Patak P, Hermann DM. From bedside to bench: How the clinical reality should instruct the modeling of stroke. Rodent Models of Stroke. In: Dirnagl U. Humana Press, Springer Verlag, New York. 2010.
18. Hermann DM. Anatomy and physiology of the cerebral vascular system. Vascular Neurology. In: Hermann DM, Steiner T, Diener HC, eds. Thieme-Verlag, Stuttgart, 2010, 1 :3-7.
19. Reitmeir R, Hermann DM. Pathophysiology of vascular-neurological diseases In: Vascular Neurology. In: Hermann DM, Steiner T, Diener HC, eds. Thieme-Verlag, Stuttgart, 2010; 8-13.
20. Bassetti CL, Hermann DM. Clinical syndromes in vascular neurology. Vascular Neurology. In: Hermann DM, Steiner T, Diener HC, eds. Thieme-Verlag, Stuttgart. 1: 2010; 14-25.
21. Bacigaluppi M, Hermann DM. Hypercholesterolemia, hyperhomocysteinemia and atherosclerosis. Vascular Neurology. In: Hermann DM, Steiner T, Diener HC, eds. Thieme-Verlag, Stuttgart. 2010; 1: 36-44.
22. Hermann DM, Teschler H, Bassetti C. Associated sleep disordered breathing. Vascular Neurology. In: Hermann DM, Steiner T, Diener HC, eds. Thieme-Verlag, Stuttgart. 2010; 1: 74-76.
23. Hermann DM, Patak P. Smoking and substance abuse. Vascular Neurology. In: Hermann DM, Steiner T, Diener HC, eds. Thieme-Verlag, Stuttgart. 2010; 1: 88-90.
24. Hermann DM, Patak P. Oral contraceptives and hormone replacement therapy. Vascular Neurology. In: Hermann DM, Steiner T, Diener HC, eds. Thieme-Verlag, Stuttgart. 2010; 91-92.
25. Hermann DM. Challenges pharmacological therapies in vascular neurology. Vascular Neurology. In: Hermann DM, Steiner T, Diener HC, eds. Thieme-Verlag, Stuttgart. 2010; 1: 121-123.
26. Bacigaluppi M, Hermann DM. Cholesterol reduction and stabilization of vascular function. Vascular Neurology. In: Hermann DM, Steiner T, Diener HC, eds. Thieme-Verlag, Stuttgart. 2010; 1: 149-155.
27. Hermann DM, Bassetti CL. Treatment of sleep-associated breathing disorders. Vascular Neurology. In: Hermann DM, Steiner T, Diener HC, eds. Thieme-Verlag, Stuttgart. 2010; 171-173.
28. Hermann DM, Bassetti C. Ischemic stroke: epidemiology, presentation and classification. Vascular Neurology. In: Hermann DM, Steiner T, Diener HC, eds. Thieme-Verlag, Stuttgart. 2010; 191-194.
29. Todica O, Wiltfang J, Hermann DM. Vascular dementia. Vascular Neurology. In: Hermann DM, Steiner T, Diener HC, eds. Thieme-Verlag, Stuttgart. 2010; 269-276.
30. Patak P, Kastrup O, Hermann DMRare stroke syndromes. Vascular Neurology. In: Hermann DM, Steiner T, Diener HC, eds. Thieme-Verlag, Stuttgart. 2010; 277-282.
31. Bassetti CL, Hermann DM. Pitfalls in clinical diagnostics. Vascular Neurology. In: Hermann DM, Steiner T, Diener HC, eds. Thieme-Verlag, Stuttgart. 2010; 321-324.
32. Hermann DM, Steiner T, Diener HC. Perspectives in Vascular Neurology Vascular Neurology. In: Hermann DM, Steiner T, Diener HC, eds. Thieme-Verlag, Stuttgart. 2010; 339-341. 33. Hermann DM, Rosenkranz M. Transient global amnesia. Therapy and outcome of neurological diseases. In: Brandt T, Diener HC, Gerloff C, eds. Kohlhammer-Verlag, Stuttgart. 2012; 6.
34. Remi J, Hermann DM, Hummel F, Noachtar S. sleep. Therapy and outcome of neurological diseases. In: Brandt T, Diener HC, Gerloff C, eds. Kohlhammer-Verlag, Stuttgart. 2012.
35. Kastrup O, Hermann DM, Diener HC. Side effects of drug therapies in neurology. Therapy and outcome of neurological diseases. In: Brandt T, Diener HC, Gerloff C, eds. Kohlhammer-Verlag, Stuttgart. 2012.


PUBLICATION OF A TEXTBOOK


1. Hermann DM, Steiner T, Diener HC. Vaskuläre Neurologie, 1. Auflage. Thieme-Verlag, Stuttgart. 2010; 354.

Naeem Mahfooz, MD

Resident Physician
Pediatric Neurology
University at Buffalo
Buffalo, NY, USA

BiographyResearch InterestScientific ActivitiesPublications

Dr. Mahfooz graduated in 2006 from King Edward Medical College. He had done his Pediatric Internship and Residency from the State University of New York at Buffalo. Presently, he is doing his Pediatric Neurology Residency from University at Buffalo. He is currently involved in multiple research projects. His future goal is to become an academic Pediatric Epileptologist.

His areas of interests include: Multiple sclerosis, Pediatric epilepsy, Myelination patterns and epilepsy surgery.

PROFESSIONAL ASSOCIATIONS

• Member - American Academy of Neurology (AAN)
• Member - American Academy of Pediatrics (AAP)
• Member - American Medical Association (AMA)


POSTER PRESENTATIONS

• Associations of serum cholesterol with clinical outcomes in multiple sclerosis.Weinstock-Guttman B, Mahfooz N, Zivadinov R, Carl E, Ramanathan M. ECTRIMS 2010, October 13-16, Göteborg, Sweden
• Serum Cholesterol Profiles Adversely Affect Clinical and MRI Outcomes in Multiple Sclerosis.Weinstock-Guttman B, Zivadinov R, Mahfooz N, Carl E, Drake A, Masud MW, Teter BE, Mehta B, Ramanathan M POSTER at American Academy of Neurology. 2011 April 9-16, Honolulu, Hawaii
• Cholesterol affects retinal nerve fibre layer thickness in MS patients with optic neuritis.Kardys A, Weinstock-Guttman B, Dillon M, Masud MW, Weinstock N, Mahfooz N, Lang J, Weinstock A, Lincoff N, Zivadinov R, Ramanathan M. ECTRIMS 2012. October 10-13, Lyon, France


SCIENTIFIC PRESENTATIONS

The Prevalence of Breakthrough Seizures in Pediatric Patients on Multiple Anti-Epileptic Drugs Oral Presentation at Senior Resident Presentation DayMay2012, Buffalo, NY.

Publications


1. Guttman B, Zivadinov R, Mahfooz N, et al. Serum lipid profiles are associated with disability and MRI outcomes in multiple sclerosis. Neuroinflammation. 2011; 8: 127. doi: 10.1186/1742-2094-8-127
2. Kardys A, Guttman B, Dillon M, et al. Cholesterol affects retinal nerve fiber layer thickness in patients with multiple sclerosis with optic neuritis. Eur J Neurol. 2013; 20(9): 1264-12671. doi: 10.1111/ene.12162
3. Masud M, Weinstock N, Mahfooz N, et al. Assessment of socio demographic risk factors involved in coronary artery disease seen in patients presenting in coronary outdoor. Annals King Edward Med Coll. 2006; 12(3): 444-445.

Joseph R. Shiber, MD, FACP, FACEP, FAAEM, FCCM

Associate Professor
Departments of Emergency Medicine and Surgical Critical Care
Co-Director Neuroscience ICU
University of Florida – College of Medicine
Jacksonville, FL, USA

BiographyResearch InterestScientific ActivitiesPublications

Dr. Shiber completed his undergraduate degree at Johns Hopkins University in 1990 and did additional graduate studies and research at JHU and JHMI. He graduated from medical school at University of Maryland in 1996. Dr. Shiber stayed at Maryland to be the first resident in the combined Emergency and Internal Medicine (EM-IM) program and later was chief resident. He completed fellowship in Critical Care at the R Adams Cowley Shock Trauma Center at the U. of MD. Previously he has been on faculty at East Carolina University where he was Program Director of the EM-IM residency and Medical Director of the Critical Care Consult service from 2001 to 2007. Dr. Shiber then joined the Baylor College of Medicine faculty, where he was the Director of Emergency Critical Care at Ben Taub General Hospital and an Intensivist at the Methodist Hospital of Houston. Since 2011, Dr. Shiber an Associate Professor of Emergency Medicine and Surgical Critical Care at U. FL College of Medicine - Jacksonville and the Co-Director of NSICU at U FL Health.

His research interests include: Adult resuscitation, cardiovascular and neurovascular emergency and critical care, ARDS, medical education.

AWARDS & HONORS

• (1990) Curtis R. Richter Award for Outstanding Graduate in Behavioral Biology Received B.A. with Departmental Honors, Johns Hopkins University
• (1993) Award for Excellence in Teaching, University of Maryland Prematriculation Summer Program
• (1995) Alpha Omega Alpha membership
• (1996) Earl I. Pass Award for Exceptional Proficiency in Internal Medicine, University of Maryland
• (2000) Exemplary Score on In- Service Exam, University of Maryland
• (2001) J. Dougherty Award for Outstanding Emergency Medicine Resident, All- City Inter- Residency Medical Jeopardy Champion: Baltimore, MD, 2nd Place Clinical Abstract at Maryland A.C.P. Research Day
• (2002) Semi- finalist: SAEM CPC Competition Discussant, ECU Dept of Emergency Medicine Residency Annual Faculty Teaching Award
• (2003) ECU Dept of Internal Medicine Chief Residents Certificate of Appreciation
• (2004) Elected Fellow, American College of Emergency Physicians (FACEP), Included in Whos Who in Medical Sciences Education, ECU Department of Internal Medicine, Chief Service Award of Excellence
• (2005) ECU Dept of Emergency Medicine Residency Annual Faculty Teaching Award, Mentor: Best Oral Presentation at ECU EM Residency Research Day, JEM article selected for inclusion in EM Journal Watch
• (2006) Honorary Member, ECU Alpha Epislon Delta: Pre- Medical Honor Society, Included in Whos Who in America, John Mitchell Award by Journal of Emergency Medicine for best original research article
• (2007) Included in Whos Who Among American Teachers & Educators, ECU Dept of Internal Medicine Teaching Award from 2nd Year Residents, ECU Dept of Internal Medicine Teaching Award from 3rd Year Residents, ECU Dept of Emergency Medicine Residency Annual Faculty Teaching Award
• (2008) Elected Fellow, American Academy of Emergency Medicine (FAAEM)
• (2009) Highest In- training Exam Score: U. MD Trauma/Critical Care Fellowship, Elected Chair, ACEP- Critical Care Medicine Section
• (2010) Elected Fellow, American College of Physicians (FACP), R Adams Cowley Shock Trauma Center 2010 Hero Award
• (2011) Included in Marquis Whos Who in Medicine and Healthcare
• (2012) Elected SCCM Committee on FCCS, Elected Fellow, American College of Critical Care Medicine (FCCM), UF Exemplary Teaching Award
• (2013) ACEP Service to Section Award, ACEP Promoting Section Membership Award of Distinction, ACEP Certificate of Appreciation for Critical Care Medicine Section
• (2014) UF Exemplary Teaching Award, ACEP Outstanding Section Newsletter Award of Distinction


PROFESSIONAL SOCIETY MEMBERSHIPS AND LEADERSHIP

• (1995-Present) Member, AOA Honor Medical Society
• (1998-Present) Member, American College of Emergency Physicians; Chair, Section of Critical Care Medicine (2011-2013); Member, Educational Committee (2011-2012, and 2014-2016); Member, Emergency Medicine Practice Committee (2013-2015)
• (2000-Present) Member, Society for Academic Emergency Medicine
• (2001-Present) Member, American Medical Association
• (2001-2007) Member, North Carolina Medical Society
• (2005-2007) Member, North Carolina Tactical Medicine Association
• (2006-Present) Member, Alpha Epislon Delta: Pre- Medical Honor Society
• (2007-Present) Member, American College of Physicians
• (2008-Present) Member, American Academy of Emergency Medicine; Member, Board or Directors FLAAEM (2013-2015)
• (2009-Present) Member, Society of Critical Care Medicine; At-Large Board Member EM Section; Member, FCCS Committee

1. Nelson RJ, Shiber JR. Photoperiod affects responsiveness to 6MBOA in house mice. Biology of Reproduction. 1990; 43: 586-591.doi: 10.1095/biolreprod43.4.586
2. Wible CG, Shiber JR, Olton DS. Hippocampus, fibria/fornix, amygdyla and memory: object discrimination in rats. Behavioral Neuroscience. 1992; 106: 751-761.doi: http://dx.doi.org/10.1037/0735-7044.106.5.751
3. Blom MC, Shiber JR, Nelson RJ. Learned conditioned immunosupression is associated with increased risk of chemically induced tumors. Neuro immunomodulation. 1995; 2: 92-99.
4. Shiber JR, Matu A. Serum phosphate abnormalities in the emergency department. Journal of Emergency Medicine. 2002; 23(4): 395-400.doi: http://dx.doi.org/10.1016/S0736-4679(02)00578-4
5. Boesiger B, Shiber JR. Subarachnoid hemorrhage diagnosis by CT and LP: Are 5th generation CT scanners better at identifying SAH? Journal of Emergency Medicine. 2005; 29(1): 23-28.doi: http://dx.doi.org/10.1016/j.jemermed.2005.02.002
6. Shiber JR. Lactic acidosis due to nucleoside analogues. American Journal of Emergency Medicine. 2005; 23(4): 582-583.
7. Shiber JR. Isolated angioedema of the arytenoids. Images in Clinical Medicine. New England Journal of Medicine. 2005; 353(17).
8. Shiber JR, Santana J. Dyspnea. Medical Clinics of North America: Office Based Emergencies. NY, McGraw-Hill. 2006; 453-479. doi: 10.1016/j.mcna.2005.11.006
9. Shiber JR. Errors in emergency practice: Fourniers gangrene. Emergency Medicine. 2006; 34-35.
10. Shiber JR. Complications and benefits of drainage of massive pleural effusions. Ann Emerg Med. 2007; 49(4): 544-545.doi: http://dx.doi.org/10.1016/j.annemergmed.2006.10.031
11. Shiber JR. Suppurative Pericarditis: Acute infections and chronic complications. Hospital Physician. 2008; 44(1): 9-18.
12. Shiber JR, Fontane E, Hensler M. Pick your poison: clonidine patch ingestion. Peds Emerg Care. 2007; 23(12): 1-3.
13. Shiber JR, Wooten L. Septic digital emboli due to streptococcus pyogenes. Ann Emerg Med. 2007; 50(6): 740-748.
14. Shiber JR, Carter K. Open Mandibular Fracture with Malocclusion. Images in Clinical Medicine: New England Journal of Medicine; NEJM. 2008; 358(5): 512.doi: 10.1056/NEJMicm065053
15. Hollis J, Grangier C, Babb J, et al. Implementation of a statewide system for coronary reperfusion of ST-segment elevation myocardial infarction. JAMA. 2007; 298(20): 2371-2380.
16. Shiber JR, Longley M, Brewer K. Emergency department hyperutilization. American Journal of Emergency Medicine. 2009; 27(5): 588-594.
17. Shiber JR. Posterior sternoclavicular dislocation. J Emerg Med. 2011; 40(3): e53-e54.
18. Shiber JR, Fines R. Cerebral hemorrhage due to hyperleukocytosis. J Emerg Med. 2011; 40(6): 674-677. doi: http://dx.doi.org/10.1016/j.jemermed.2008.11.018
19. Shiber JR, Fontane E, Adewale A. Stroke Registry: Hemorrhagic versus ischemic stroke. American Journal of Emergency Medicine. 2010; 28(3): 331-333. doi: 10.1016/j.ajem.2008.10.026
20. Shiber JR. Severe Non-Anion Gap Metabolic Acidosis Induced By Topiramate: A Case Report. J Emerg Med. 2010; 38(4): 494-496.doi: 10.1016/j.jemermed.2008.11.017
21. Pollack C, Schreiber D, Goldhaber S, et al. Initial Report of EMPEROR: A multi-site registry of emergency department patients with pulmonary embolism. J Am Coll Cardiol. 2011; 57(6): 700-706.
22. Shiber JR, Cushman JG. Traumatic Lumbar Visceral Hernia. J Emerg Med. 2012; 43: e59-e60.doi: http://dx.doi.org/10.1016/j.jemermed.2010.11.047
23. Shiber J, Cardarelli M. Traumatic Ventricular Septal Defect and Tricuspid Regurgitation. J Emerg Med. 2012; 43: e141-142.doi: http://dx.doi.org/10.1016/j.jemermed.2010.11.015
24. Shiber JR, Fontane E. Bilateral Renal Artery Dissection. Trauma. 2012.
25. Shiber JR, Macindoe C, Flower O, Knight WA, Bosel J. Neurological Emergencies. Emerg Med Int. 2012.
26. Shiber JR. Pyomyositis Due to Anabolic Steroid Injection. J Emerg Med. 2013; 44: e69-e70.doi: http://dx.doi.org/10.1016/j.jemermed.2011.06.008
27. Shiber JR, Datillo W. Prostatitis or Prostatic Abscess. J Emerg Med. 2013; 44: e121-122.
28. Shiber JR. Neurological Misdiagnosis in the ED. ED Legal Letter. 2013; 24: 32-36.
29. Shiber JR. DVT and Pulmonary Embolism with Stroke. Acta Neurologica Belgica. 2014; 114(2): 145-148.
30. Shiber JR, Journey J. Traumatic Ventral Hernia: The Seat-Belt Sign. J Emerg Med. 2014; 46(1): e19-e20. doi: 10.1016/j.jemermed.2013.08.020
31. Andrew P, Shiber JR, Habshi N, et al. Early application of airway pressure release ventilation may reduce mortality in high-risk trauma patients: a systematic review of observational trauma ARDS literature. J Trauma Acute Care Surg. 2013; 75(4): 635-641. doi: 10.1097/TA.0b013e31829d3504
32. Shiber JR. Fear of suits stops some EPs from giving tPA. ED Legal Letter. 2013; 24: 117-120.
33. Shiber JR, Fontane E. Pick your poison: A somnolent 2-year old boy with a hyperactive brother. Peds Emerg Care. 2013; 29(9): 1033-1036.
34. Shiber JR, Fontane E, Monroe B. Olivier Syndrome: traumatic asphyxia. West J Emerg Med. 2013; 14(6): 65.doi: 10.5811/westjem.2013.7.18581
35. Shiber JR, Schmidt A. A Curious chest radiograph after line placement. J Emerg Med. 2014; 46(4): e131.doi: http://dx.doi.org/10.1016/j.jemermed.2013.09.019
36. Shiber JR, Fontane E. Quinckes disease: isolated uvulitis. West J Emerg Med. 2014; 15(6): 663.doi: 10.5811/westjem.2014.6.22525
37. Shiber JR, Makary R. Pulmonary-renal syndrome due to microscopic polyangiitis. Ann Emerg Med. 2014.
38. Shiber JR. Lingual angioedema due t ACE-inhibitor. Trop Med & Surg. 2014.doi: 10.4172/2329-9088.1000161
39. Shiber JR, Diaz J, Bohsali K. Bilateral anterior shoulder dislocations due to seizure. Trop Med & Surg. 2014.
40. Shiber JR, Fontane E, Prisk D. Atraumatic splenic rupture: dreaded complication of splenomegaly. Trop Med & Surg. 2014. doi: 10.4172/2329-9088.1000162

Mohtashem Samsam, MD, PhD

Associate Professor of Medicine
Burnett School of Biomedical Sciences (BSBS)
College of Medicine, University of Central Florida
4000 Central Florida Blvd, HPA-II 320
Orlando, FL 32816, USA

BiographyResearch InterestScientific ActivitiesPublications
Education


• PhD in Neuroscience (1997-2002)
• Doctor of Medicine (MD) (1991-1996)
• Associate Degree of Radiology (1985-1987)
• Undergraduate studies: were done in Iran (1970-1982)


Positions and Professional Experiences


• Associate Professor of Medicine, (2013-present)
• Assistant Professor of Medicine, (2007-2013)
• Associate Professor of Medicine, (2006-present)
• Instructor of Anatomy, Clinical Neuroanatomy, Clinical Embryology, and Molecular Neuroscience (2004-2007)
• Associate Professor of Anatomy and Neuroscience (2003-2004)
• Academic senior post-doc in Developmental Neurobiology (1999-2002)

His research interests include: Pathomechanism of Autism Spectrum Disorders, Role of Inflammation in and Treatment of neurological and psychiatric disorders, Mechanisms of primary headache disorders.

PROFESSIONAL SOCIETY MEMBERSHIP


• American Association of Anatomists
• Society for Neuroscience
• Society for Simulation in Healthcare


AWARDS


• Distinguished Member Nomination of the National Society of Collegiate Scholars, UCF, (2013)
• Teaching Incentive Program (TIP) Award, UCF, College of Medicine (COM), (2012-2013)
Keeper of the Creed Award in Scholarship, UCF, COM, (2011-2012) This is for leadership in teaching, medical research, and commitment to student success. http://med.ucf.edu/news/2012/05/dr-samsam-is-keeper-of-the-creed/
• Scholarship of Teaching and Learning (SoTL) Award, UCF, COM, (2011-2012)
• Excellence in Undergraduate Teaching Award, UCF, COM (2009-2010)
• Golden Apple Excellence in Teaching Award & Professor of the Year, UCF Premed-American Medical Student Association (AMSA) for 8 years in the row, (2004-2005, 2005-2006, 2006-2007, 2007- 2008, 2008- 2009, 2009- 2010, 2010- 2011, 2011- 2012)
• Hungarian national 3rd prize of graduate student award, Budapest, Hungary, (1991)


SERVICE ON UNIVERSITY AND DEPARTMENTAL COMMITTEES


• Chair, Biology Curriculum Alignment Initiative, UCF and Partnering Central Florida Colleges & Regional Campuses, (2014-present)
• Chair, Teaching-Track Promotion Criteria and Procedures Evaluation Committee, Burnett School of Biomedical Sciences (BSBS), College of Medicine (COM), UCF (2014-present)
• Member, COM Faculty Award Committee, COM, UCF, (2014-present)
• Member, COM Teaching Incentive Program Award Criteria Committee, COM, UCF, (2014-present)
• Coordinator, senior undergraduate STEM internship program, sponsored by Career Source of Central Florida, facilitated by UCF office of Experiential Learning, BSBS, COM, UCF, (2013- present)
http://med.ucf.edu/news/2014/07/collaboration-creating-on-the-job-research-training-career-opportunities/
• Member, Integrated Medical Sciences (IMS) and MD/PhD curriculum committee, developing a Masters Program called: IMS track in the Biomedical Science, BSBS, COM, UCF, (2013-present)
• Member (co-writer of white paper) of PhD track committee in Neuroscience, Burnett School of Biomedical Sciences (BSBS), College of Medicine (COM), UCF, (2012-present)
• Chair, Task Force for Teacher Professional Development Program. I proposed the white paper of the program which is currently under review in graduate curriculum committee, BSBS, COM, UCF, (2012- present)
• Chair, Task Force for Pre-Collegiate Summer Program for high school students. I proposed the white paper of this tuition fee program that is designed to give 1-2 college credits to high school students for 1-2 weeks education in university during summer, BSBS, COM, UCF, (2012-2013)
• Member, University Faculty Advisory Council, Student Development and Enrollment Services (SDES), UCF, (2012-present)
• Member, Board of Directors, Florida Chapter of Neuroscience, UCF, (2012- present)
• Member of the UCF COM Students LCME Subcommittee (2012)
• Member, Online Studies Committee, Burnett School of Biomedical Sciences (BSBS), COM, UCF, (2011)
• Chair, Teaching-Track Promotion Criteria and Procedures Committee, BSBS, COM, UCF, (2009- 2011)
• Member, Medical Program Curriculum Planning Committee at UCF, (2006-2008)
• Member, Human body 1 (HB1) subcommittee, we wrote the course contents of Biochemistry and Cell biology together with 4 other colleagues in HB1 subcommittee, UCF, COM, (2006-2007)
• Chair, of four subcommittees in 2nd year curriculum and with 7 other clinical faculty, we wrote the syllabi and detailed course contents of the gastrointestinal (GI) disorders, Urology/ Nephrology, Endocrine disorders, OB/GYN in S3 and S5 modules of our UCF COM
• Chair, GI tract disorders subcommittee
• Chair, nephrology/ urology subcommittee
• Chair, endocrine & nutritional disorders subcommittee
• Chair, reproductive system subcommittee, Curriculum Planning Committee, COM, UCF, (2007)
• Member, Advisory Board Committee, International Brain Conf., UCF, (2007-present)
• Member, Advisory Board, faculty center for teaching & learning, UCF, (2005-2011)
Reviewed numerous internal grant applications to this center annually, (2006-2011)
• Member, Undergraduate Curriculum Committee, Burnett School, COM, UCF, (2005-2007)
• Member, research committee, Saba Univ. School of medicine, Saba, Netherlands-Antilles (2003-2004)

1. Samsam M, Ahangari R, Naser SA. Pathophysiology of autism spectrum disorders: Revisiting gastrointestinal involvement and immune imbalance. World J Gastroenterol. 2014; 20(29): 9942-9951. doi: 10.3748/wjg.v20.i29.9942.
2. Samsam M. Central nervous system drugs in treatment of neurological disorders. Editorial, Cent Nerv Syst Agents Med Chem. 2012; 12: 153-157.
3. Samsam M. Central nervous system acting drugs in treatment of migraine headache. Cent Nerv Syst Agents Med Chem. 2012; 12: 158-172. doi: 10.2174/187152412802430147#sthash.NkybAmBU.dpuf
4. Samsam M. Role of inflammation in neurological and psychiatric disorders. Editorial AIAA-MC. 2010; 3: 166-169.
5. Samsam M, Coveñas R, Ahangari R, Yajeya J. Neuropeptides and other chemical mediators, and the role of anti-inflammatory drugs in primary headaches. AIAA-MC. 2010; 3: 170- 188. doi: 10.2174/1871523011009030170
6. Samsam M Coveñas R Ahangari R Yajeya J, Narváez JA. Role of neuropeptides in migraine; where do they stand in the latest expert recommendations in migraine treatment? Drug Development Research. 2007; 68: 298-314. doi: 10.1002/ddr.20193
7. Ruhlman T, Ahangari R, Devine A, Samsam M, Daniell H. Expression of cholera toxin B-proinsulin fusion protein in lettuce and tobacco chloroplasts - oral administration protects against development of insulitis in non-obese diabetic mice. Plant Biotechnol J. 2007; 5: 495-510. doi: 10.1111/j.1467-7652.2007.00259.x
8. Limaye A, Koya V, Samsam M, Daniell H. Receptor mediated oral delivery of a bioencapsulated green fluorescent protein expressed in transgenic chloroplasts into the mouse circulatory system. FASEB J. 2006; 20: 959-961. doi:
9. Holtmann B, Wiese S, Samsam M, et al. Triple knockout of CNTF/ Lif/ CT1 defines cooperative and distinct roles of these neurotrophic factors for motoneuron maintenance and function. J Neurosc. 2005; 25: 1778-1787. doi: 10.1523/JNEUROSCI.4249-04.2005
10. C sillik B, Mihaly A, Krisztin-Peva B, et al. GABAergic parvalbumin-immunoreactive large calyciform presynaptic complexes in the reticular nucleus of the rat thalamus. J Chem Neuroanat. 2005; 30: 17-26. doi: 10.1016/j.jchemneu.2005.03.010
11. Berghoff M, Samsam M, Müller M, et al. Neuroprotective effect of the immune system in a mouse model of severe dysmyelinating hereditary neuropathy: Enhanced axonal degeneration following disruption of the RAG-1 gene. Mol Cell Neurosci. 2005; 28: 118-127. doi: 10.1016/j.mcn.2004.09.001
12. Kobsar I, Berghoff M, Samsam M, et al. Immune deficiency preserves myelin integrity and reduces axonopathic changes in connexin32 deficient mice. Brain. 2003; 126: 804-813.
13. Samsam M, Weiqian M, Wessig C, et al. The Wlds mutation delays the severe axonal loss in a genetic model for myelin-related axonopathy. J Neurosci 2003; 23: 2833-2839.
14. Samsam M, Coveñas R, Ahangari M, et al. Implications of somatostatin, neurotensin and methionin-enkephalin in an experimental model of headache. Rev Neurol. 2002; 34: 724- 729.
15. Samsam M, Frei R, Marziniak M, Martini R , Sommer C. Impaired sensory function in heterozygous P0 knockout mice is associated with nodal changes in sensory nerves. J Neurosc Res. 2002; 67: 167-173.
16. Samsam M, Coveñas R, Csillik B, et al. Depletion of substance P, neurokinin A and calcitonin geme-related peptide from the contralateral caudal trigeminal nucleus following a unilateral electrical stimulation of the trigeminal ganglion; the functional neuroanatomy underlying the clinical manifestation of generalized migraine headaches. J Chem Neuroanatomy. 2001; 21: 161-169.
17. Samsam M, Coveñas R, Ahangari R, Yajeya J, Riquelme R, Narváez JA. Changes in neuropeptide distribution in the caudal trigeminal nucleus following electrical stimulation of the trigeminal ganglion: an experimental migraine model. Mapfre medicina espana. 2000; 11(2): 111-118.
18. Samsam M, Coveñas R, Ahangari R, Yajeya J, Narváez JA, Tramu G. Simultaneous depletion of neurokinin A, substance P and calcitonin gene related peptide immunoreactivities in the caudal trigeminal nucleus of the rat following electrical stimulation of the Gasserian ganglion: a possible co-release of neuropeptides. Pain. 2000; 84: 389-395.
19. Samsam M, Coveñas R, Ahangari R, Yajeya J, Narváez JA, Tramu G. Neurokinin A and Substance P and calcitonin gene-related peptide immunoreactivities in the rat caudal trigeminal ganglion. Neuroscie Let. 1999; 261: 1-4.
20. Knyihar-Csillik E, Tajti J, Samsam M, Sary Gy, Buzas P, Vecsei L. Depletion of calcitonin gene-related peptide from the caudal trigeminal nucleus of the rat after electrical stimulation of the Gasserian ganglion. Exp Brain Res. 1998, 118: 111-114.
21. Knyihar-Csillik E, Tajti J, Samsam M, Sary Gy, Vecsei L. Effect of serotonin agonist(Sumatriptan) on the peptidergic innervation of the rat cerebral dura mater on the expresion of C-fos in the caudal trigeminal nucleus in an experimental migraine model. J Neurosci Res. 1997; 48: 449-464. doi: 10.1002/(SICI)1097-4547(19970601)48:5<449::AID-JNR6>3.0.CO;2-E
22. Knyihar-Csillik E, Tajti J, Samsam M, Sary Gy Vecsei L. Electrical stimulation of the Gasserian ganglion induces structural alterations of the calcitonin gene related peptide-immunoreactive perivascular sensory nerve terminals in the rat cerebral dura mater: a possible model of migraine headache. Neuroscience Lett. 1995; 1984: 189-192. doi: 10.1016/0304-3940(94)11203-U
23. Knyihar-Csillik E, Torok A, Samsam M, Csillik B. Regeneration of dorsal column pathways in peripheral bypass autografts implanted in the spinal cord of adult rats. Acta Biochim Biophysi Hung. 1992; 26: 97-103.
24.Samsam M. Drugs against calcitonin gene-related peptide and its receptor used in the treatment of migraine: What are the new progresses?. Neuro Open J. 2015; 2(3): 79-91. doi: 10.17140/NOJ-2-117

Rajendram V Rajnarayanan, PhD

Assistant Professor of Pharmacology and Toxicology
Associate Director of IMSD-CLIMB program at UB
School of Medicine and Biomedical Sciences
State University of New York, Buffalo
3435 Main Street, Buffalo, NY 14214, USA

BiographyResearch InterestScientific ActivitiesPublications
PROFESSIONAL SUMMARY:

Our laboratory seeks to understand hormone-triggered nuclear receptor signaling. Nuclear receptors are associated with various diseases including diabetes and cancer and the availability of several high resolution structures of their ligand binding domains make them attractive targets for drug discovery. Eight of the top 100 prescription drugs (accounting for about US $9 billion in sales) target a nuclear receptor. However, these drugs can cause a variety of side effects and some patients develop drug resistance.
Tamoxifen, a drug designed to selectively target the nuclear estrogen receptor which is present in 70% of breast cancer patients, induces substantial regression of breast tumors and an increase in disease-free survival. Tamoxifen binds directly to the ligand binding domain of estrogen receptor and regulates estrogen-mediated growth of breast cancer cells. Tamoxifen mimics estrogen effects in other tissues thereby providing some beneficial effects including reduced risk of osteoporosis. However, breast cancers that initially respond well to tamoxifen tend to develop resistance and resume growth despite the continued presence of the antagonist.
We specifically focus on protein interactions that regulate estrogen signaling by binding to estrogen receptors. Our objective is to identify the estrogen receptor conformation-sensing regions of the interacting proteins and to discover potential small molecule sensors using state-of-the art bioinformatics and structure-based discovery tools and use them to generate a new breed of small molecular therapeutics for breast cancer therapy.


EDUCATION AND TRAINING:

• PhD, Chemistry, Tulane University (2001)
• MS, Chemistry, Indian Institute of Technology, Madras (1997)
• BS, Chemistry, Loyola College (1995)
• Postdoctoral Fellow, Proteomics and Nanotechnology, NIAMS, NIH
• Postdoctoral Fellow, Drug Discovery, Georgetown University Medical Center

His research interests include: Bioinformatics, Genomics and proteomics, Signal Transduction, Toxicology and Xenobiotics.

AWARDS AND HONORS:

• Distinguished Undergraduate Teaching and Mentoring Award (2014)
• Faculty Award of Excellence for promoting inclusion and cultural diversity (2013)
• Faculty Teaching Award (2012)
• Faculty Teaching Award (2010)


RESEARCH EXPERTISE: :

• Medicinal Chemistry and Drug Discovery: Studying molecular mechanisms of transcription factor mediated pathways and to discover small molecules that target specific transcription factor conformation. Design, synthesis and evaluation of inducers, substrates and inhibitors of drug metabolizing enzymes. We explore new chemical space by employing state-of-the-art Omics guided structure determination techniques to probe protein interactome and discover new drugs against a variety of diseases including diabetes and cancer.

1. Kumar AP, Garcia GE, Ghosh R, Rajnarayanan RV, Alworth WL, Slaga TJ. 4-Hydroxy-3-methoxybenzoic acid methyl ester: a curcumin derivative targets Akt/NF kappa B cell survival signaling pathway: potential for prostate cancer management. Neoplasia. 2003; 5(3): 255-266.
2. Nikov GN, Eshete M, Rajnarayanan RV, Alworth WL, Rajnarayanan R. Interactions of synthetic estrogens with human estrogen receptors. J Endocrinol. 2001; 170(1): 137-145.
3. Chakraborty S, Cole S, Rader N, King C, Rajnarayanan R, Biswas PK. In silico design of peptidic inhibitors targeting estrogen receptor alpha dimer interface. Mol Divers. 2012; 16(3): 441-451. doi: 10.1007/s11030-012-9378-x.
4. Abolfath RM, Biswas PK, Rajnarayanan R, Brabec T, Kodym R, Papiez L. Multiscale QM/MM molecular dynamics study on the first steps of guanine damage by free hydroxyl radicals in solution. J Phys Chem A. 2012; 116(15):3940-3945. doi: 10.1021/jp300258n
5. Simmons SS, Isokpehi RD, Rajnarayanan RV, et al. Functional Annotation Analytics of Rhodopseudomonas palustris Genomes. Bioinform Biol Insights. 2011; 5: 115-129. doi: 10.4137/BBI.S7316.
6. Isokpehi RD, Mahmud O, Rajnarayanan RV, et al. Developmental Regulation of Genes Encoding Universal Stress Proteins in Schistosoma mansoni. Gene Regul Syst Bio. 2011; 5: 61-74. doi: 10.4137/GRSB.S7491.
7. Isokpehi RD, Cohly HH, Rajnarayanan RV, et al. Candidate single nucleotide polymorphism markers for arsenic responsiveness of protein targets. Bioinform Biol Insights. 2010; 4: 99-111. doi:
8. Kostyuk N, Rajnarayanan RV, Isokpehi RD, Cohly HH, Rajnarayanan R. Autism from a biometric perspective. Int J Environ Res Public Health. 2010; 7(5). doi: 10.4137/BBI.S5498.
9. Isokpehi RD, Rajnarayanan RV, Jeffries CD, Oyeleye TO, Cohly HH. Integrative sequence and tissue expression profiling of chicken and mammalian aquaporins. BMC Genomics. 2009; 10(suppl 2): S7. doi: 10.1186/1471-2164-10-S2-S7.
10. Cohly HH, Isokpehi R, Rajnarayanan RV. Compartmentalization of aquaporins in the human intestine. Int J Environ Res Public Health. 2008; 5(2): 115-119.
11. Rajendran N, Rajnarayanan RV, Demuth DR. Molecular phylogenetic analysis of tryptophanyl-tRNA synthetase of Actinobacillus actinomycetemcomitans. Z Naturforsch C. 2008; 63(5-6): 418-428.
12. Menon V, Li D, Rajnarayanan R, et al. Functional studies of the Ssk1p response regulator protein of Candida albicans as determined by phenotypic analysis of receiver domain point mutants. Mol Microbiol. 2006; 62(4): 997-1013.
13. Sivanesan D, Rajnarayanan RV, Doherty J, Pattabiraman N. In-silico screening using flexible ligand binding pockets: a molecular dynamics-based approach. J Comput Aided Mol Des. 2005; 19(4): 213-228.
14. Rajnarayanan RV, Dakshanamurthy S, Pattabiraman N. Teaching old drugs to kill new bugs: structure-based discovery of anti-SARS drugs. Biochem Biophys Res Commun. 2004; 321(2): 372-378.
15. Rajnarayanan RV, Wang K. Ion-pair assisted recovery of matrix-assisted laser desorption/ionization mass spectral signals from SDS-containing peptide-protein mixtures. J Mass Spectrom. 2004; 39(1): 79-85.
16. Rowley CW, Rajnarayanan RV, Hopkins NE, Alworth WL. Differential expression of CYP102 in Bacillus megaterium by 17-beta-estradiol and 4-sec-butylphenol. Biochem Biophys Res Commun. 2003; 300(1): 102-106.
17. Kent UM, Mills DE, Rajnarayanan RV, Alworth WL, Hollenberg PF. Effect of 17-alpha-ethynylestradiol on activities of cytochrome P450 2B (P450 2B) enzymes: characterization of inactivation of P450s 2B1 and 2B6 and identification of metabolites. J Pharmacol Exp Ther. 2002; 300(2): 549-558. doi: 10.1124/jpet.300.2.549
18. Rajnarayanan RV, Rowley CW, Hopkins NE, Alworth WL. Regulation of phenobarbital-mediated induction of CYP102 (cytochrome P450(BM-3)) in Bacillus megaterium by phytochemicals from soy and green tea. J Agric Food Chem. 2001; 49(10): 4930-4936.

James H. Halsey Jr, MD

Professor Emeritus
Department of Neurology
University of Alabama School of Medicine
1720 2nd Ave. S. FOT 1203
Birmingham, AL 35294-3412, USA

BiographyResearch InterestScientific ActivitiesPublications
EDUCATION


• B.A. Degree - June 1955, University of Bridgeport, Bridgeport, Connecticut
• M.D. Degree - June 1959, YaleUniversity, New Haven, Connecticut

His research interests includes: Clinical Stroke, Brain Circulation and Oxygen Supply , Parkinsons Disease, Headache, Spine Disorders and Pain Management, General Neurology, Disability Evaluation

BOARD CERTIFICATION


• Certified in Neurology, American Board of Psychiatry and Neurology, March 1968
• Certified in Electroencephalography American Board of Clinical Neurophysiology, April 1979
• Certified in Neurosonology, American Board of Neuro Imaging 2006
• Certified in Cerebral Vascular DiseaseaseAmerican Board of Psychiatry and Neurology 2008

FULL LENGTH PAPERS


1.Halsey JH, Downie AW. Decerebrate rigidity with preservation of consciousness. J Neurol., Neurosurg. and Psychiat. 1968; 29: 350-355.
2. Halsey JH, Scott TR, Farmer TW. Adult hereditary cerebello-retinal degeneration. Neurology. 1967; 17: 87.
3. Halsey JH, Lampton TD, Raffel S. The epidemiology of carotid stenosis. J Med. Assoc of the State of Ala. 1967; 36: 1081.
4.Halsey JH, Ceballos R, Crosby E. The supra nuclear control of voluntary lateral gaze. Neurology. 1967; 17: 928.
5. Halsey JH. Cerebral infarction with transient global amnesia. Ala. J. Med. Sci. 1967; 4: 436.
6. Halsey JH, Allen N, Chamberlin HR The chronic decerebrate state of infancy - Neurologic observations in long surviving cases in hydranencephaly. Arch Neurol. 1968; 19: 339-346.
7. Halsey JH, Clark LC. Some regional circulatory abnormalities following experimental cerebral infarction. Neurology. 1970; 20: 238-246.
8.Wilson EM, Halsey JH. Bilateral jugular venous blood flow by thermal dilution. Stroke. 1970; 1: 348-355.
9. Halsey JH, Capra NF. Physiological modification of immediate ischemia due to experimental middle cerebral occlusion - its relevance to cerebral infarction. Stroke. 1971; 2: 239-246.
10. Halsey JH, Ricardo C, Alves AM. The pathogenesis of progressive stroke - Clinico-Pathologic-Correlations. Ala. J. Med. Sci. 1971; 8: 91-98.
11. Halsey JH, Allen N, Chamberlin HR. The morphogenesis of hydranencephaly. J. Neuro. Sci. 1971; 12: 187-218.
12. Wilson EM, Halsey JH. An improved thermal dilution method for measuring jugular venous flow. Stroke. 1971; 2: 128-138.
13. Halsey JH, Capra N. The course of experimental cerebral infarction - The development of increased intracranial pressure. Stroke. 1972; 3: 268-278.
14. Wilson EM, Halsey JH, Vitek JJ. Validation of jugular venous flow as an index of total cerebral blood flow. Stroke. 1972; 3: 300-321.
15. Vitek J, Halsey JH, McDowell HA. Occlusion of all four extracranial vessels with minimal clinical symptomatology. Case report Stroke. 1972; 3: 462-466.
16. Oh SJ, Halsey JH. Abnormality in nerve potentials in Fredreichs ataxia. Neurology. 1973; 23: 52-55.
17. Halsey JH, Galbraith JG, Strong E, Capra NF. A method for monitoring oxygen availability in brain. Ala J Med Sci. 1972; 9: 444-448.
18. Jamieson AD, Halsey JH. Regional cerebral blood flow determination by the hydrogen clearance technique and comparison with oxygen availability in the rabbit. Stroke. 1973; 4: 904-911.
19. Rao NS, Al ZA, Omar HM, Halsey JH. Regional cerebral blood flow in acute stroke: Preliminary experience with the 133 xenon inhalation method. Stroke. 1974.
20. Halsey JH, McFarland S. Oxygen cycles and metabolic autoregulation. Stroke. 1974; 5: 219-225.
21. Risberg J, Ali Z A, Wilson EM, Wills EL, Halsey JH. Regional cerebral blood flow by 133 xenon inhalation. Stroke. 1975; 6: 142-148.
22. Osburne RC, Halsey JH. Cerebral blood flow as a predictor of recovery from ischemia in the gerbil. Arch. Neurol. 1975; 32: 457-462.
23. Risberg J, Halsey JH, Wills EL, Wilson EM. Hemispheric specialization in normal man studied by bilateral measurements of the regional cerebral blood flow - A study with the 133-Xe inhalation technique. Brain. 1975; 98: 511-524.
24. Quayle ES, Christian ST, Halsey JH. A comparison between the magnesium requiring adenosinetriphosphatase of neuronal synaptic vesicles isolated from gerbil and rat brain. Ala J Med Sci. 1975; 12: 230-235.
25. Robert CM, Norman CF, Halsey JH. Method for measuring brain tissue pressure: Response to alteration in pCO2, systemic blood pressure and middle cerebral artery occlusion. J Neurosurg. 1975; 43: 18.
26. Wilson EM, Wills EL, Jarl R, Halsey JH, Gerard JD, May CP. Measurement of regional blood flow by the 133xenon inhalation method with an on-line computer. Compat Biol Med. 1976; 7: 143-157.
27. Kelly RA, Halsey JH. Comparison of local blood flow and oxygen availability at the same locus in the ischemic gerbil brain. Stroke. 1976; 7: 560-563.
29. Wilhelm E, Wilfred N, Holcomb C, Corssen G, Halsey JH. Oxygen supply to the spinal cord and its autoregulation. Microcir. 1976; 1: 391-394.
30. Halsey JH, Stalin G, Wilhelm E, Mardis HM. Studies in cerebral ischemia. Microvas. Res. 1977; 13:363-370.
31. BlauensteinUrs W, Halsey JH, Wilson EM, Wills EL, Jarl R. 133 Xenon inhalation method: Analysis of reproducibility. Some of its physiological implications. Stroke. 1977; 8: 92-102.
32. Halsey JH, Norman C, McFarland RS. Use of hydrogen for measurement of regional cerebral blood flow: Problem of intercompartmental diffusion. Stroke. 1977; 8: 351-357.
33. Capra NF, Vallenas M, Halsey JH. Adrenergic cerebrovascular nerves: Effect of middle cerebral artery occlusion on the catecholamine fluorescence of sympathetic cerebrovascular nerves in cats. Exp Neurol. 1977; 57: 409-418.
34. Blauenstein UW, Halsey JH, Wilson EM, Wills EL. 133 Xenon inhalation method: Significance of indicator mal distribution for distinguishing brain areas with impaired perfusion. An index for total flow. Stroke. 1978; 9: 57-66.
35. Halsey JH, BlauensteinUrs W, Wilson EM, Wills EL. Regional cerebral blood flow comparison of right and left hand movement. Neurology . 1979; 29: 21-28.
36. Halsey JH, BlauensteinUrs W, Edwin M, Wills EL. Brain activation in the presence of brain damage. Brain and Language. 1980; 9: 47-60.
37. Halsey JH, BlauensteinUrs W, Wilson EM, Wills EL. rCBF activation in a patient with right homonymous hemianopia and alexia without agraphia. Brain and Language. 1980; 9: 137-140.
38. Halsey JH, Michael O, Strong ER. Amelioration of cerebral ischemia by prior treatment of hypertension. Stroke. 1980; 11: 235-240.
39. Halsey JH, Nakai K. WariyarBalachandran: rCBF sensitivity to focal lesions. Stroke. 1981; 12: 631-635.
40. Hazelrig JB, Katholi CR, Blauenstein UW, Halsey JH, Wilson EM, Wills EL. Total curve analysis of regional cerebral blood flow with 133Xe inhalation. IEEE Trans. Biomed. Eng. 1981; 28: 609-616.
41. Andras E, Edward S, Halsey JH. Stability of oxygen transmissibility during ischemia. Neurological Research. 1981; 3: 211-228.
42. Coyer PE, Halsey JH, Strong ER. Reversible and irreversible effects of pO2 alterations on two groups of Aplysia neurons. Comp Biochem Physiol. 1981; 68A: 579-587. doi: 10.1016/0300-9629(81)90364-9
43. Eke A, Strong ER , Halsey JH. Microregional oxygen transmissibility following ischemia in the brain cortex. Adv Physiol. Sci. 1981; 25: 47-51.
44. Garcia JH, Mitchem HL, Briggs L, et al. Transient Ischemic attacks in subhuman primates. Neuronal injury as a function of cerebral ischemia and reperfusion. J. Neuropathol Exp Neurol. 1982; 41: 357.
45. Marcoux FW, Morawetz RB, Crowell RM, Umberto D, Halsey JH. Differential regional vulnerability in transient focal cerebral ischemia. Stroke. 1982; 13(3): 339-346.
46. Martin RM, Halsey JH. A critical evaluation of oxygen disappearance during stop flow in the gerbil brain. Neurol. Res. 1982; 4: 21-34.
47. Halsey JH, Morawetz RB, BlauensteinUrs W. The hemodynamic effect of STA-MCA bypass. Stroke. 1982; 13(2): 163-167.
48. Hudetz AG, Halsey JH, Horton CR, Conger KA, Reneau DD. Mathematical simulation of cerebral blood flow in focal ischemia. Stroke. 1982; 13: 693-700.
49. Leli DA, Hannay HJ, Falgout JC, et al. Focal changes in cerebral blood flow produced by a test of right-left discrimination. Brain and Cognition. 1982; 1: 206-223.
50. Butler RW, Dickinson WA, Katholi C, Halsey JH. The comparative effects of organic brain disease on cerebral blood flow and measured intelligence. Ann Neurol. 1983; 13: 155-159.
51. Conger KA, Moraes HP, Strong ER, et al. Computer controlled blood pressure changes required for steady state oxygen control of partial ischemia in rat brain cortex. J Neuropathol Exp Neurol. 1983; 42: 336.
52. Garcia JH, Mitchem HL, Briggs L, et al. Transient focal ischemia in subhuman primates: neuronal injury as a function of local cerebral blood flow. J Neuropathol. Exp Neurol. 1983; 42: 44-60.
53. Hannay HJ, Leli DA, Falgout JC, Katholi CR, Halsey JH. rCBF for middle-aged males and females during right-left discrimination. Cortex. 1983; 19: 465-474. doi: 10.1016/S0010-9452(83)80028-8
54. OBrien MD, Strong ER. The effect of hypertension on ischemic cerebral edema in spontaneously hypertensive rats. Neurol. Res. 1983; 5: 83-93.
55. Leli DA, Hannay HJ, Falgout JC, Katholi CR, Halsey JH. Age effects on cerebral blood flow changes produced by a test of right-left discrimination. Neuropsychologia. 1983; 21: 525-533. doi: 10.1016/0028-3932(83)90008-8
56. Leli DA, Hannay HJ, Falgout JC, et al. Relevance of sensorimotor task components to the interpretation of task related blood flow changes. Neuropsychologia. 1984; 22: 79-84. doi: 10.1016/0028-3932(84)90010-1
57. Warren LR, Butler RW, Katholi CR, McFarland CE, Crews EL, Halsey JH. Focal changes in cerebral blood flow and EEG during carotid occlusion for endarterectomy (without shunting) and neurologic outcome. Surgery. 1984; 96(1): 184-189.
58. Morawetz RB, Zeiger HE, McDowell HA, et al. Correlation of cerebral blood flow and EEG during carotid occlusion for endarterectomy (without shunting) and neurologic outcome. Surgery. 1984; 96: 184-189.
59. Leli DA, Katholi CR, Hazelrig JB, et al. Measurement of activated rCBF by the 133Xe inhalation technique: A comparison of total versus partial curve analysis. Stroke. 1985; 16(2): 274-282.
60. Faught E, Mitchem HL, Conger K, Garcia H, Halsey J. Patterns of EEG frequency content during experimental transient ischemia in subhuman primates. Neurol. Res. 1987.
61. Hazelrig JB, Halsey JH,Wilson EM, Wills EL. Comparison of external lung monitoring with end-tidal air detection using the 133-xenon inhalation method. Stroke. 1985; 16: 964-968.
62. Warren L, Butler R, Katholi C, Halsey J. Age differences in cerebral blood flow during rest and during mental activation measurements with and without monetary incentive. J. Gerontol. 1985; 40: 53-59.
63. Leli D, Katholi C, Hazelrig J, et al. Measurement of activated rCBF by 133-xenon inhalation technique: A comparison of total versus partial curve analysis. Stroke. 1985; 16: 274-282.
64. Halsey JH, McDowell HA, Gelman S. Transcranial Doppler and rCBF compared in carotid endarterectomy. Stroke. 1986; 17: 1206-1208.
65. Halsey JH, Conger KA, Hudetz AG, Hobbes FMG, Garcia JH. Strong ER The role of tissue acidosis in ischemic tissue injury: The concept of the pH integral. Neurol. Res. 1988; 10: 97-104.
66. Halsey J. Progressive lacunar infarction with demonstrated patency of the middle cerebral artery. Stroke. 1986; 17: 1028-1030.
67. Hannay HJ, Falgout JC, Leli DA, Katholi C, Halsey J, Wills E. Focal right temporo-occipital blood flow changes associated with judgment of line orientation. Neuropsychologia. 1987; 25: 755-764.
68. Hudetz A, Conger K, Halsey J, Pal M, Dohan O, Kovach A. Pressure distribution in the pial arterial system of rats based on morphometric data and mathematical models. J. CBF Metabol. 1987; 7: 352-355.
69. Halsey J. Application of transcranial Doppler sonography to intracranial vascular diagnosis. Applied Radiology. 1987; 16: 62-66.
70. Halsey JH. Prognosis of acute hemiplegia estimated by transcranial Doppler. Stroke. 1988; 19: 648-649.
71. Faught E, Conger K, Garcia J, Halsey J. Patterns of EEG frequency content during experimental transient ischemia in subhuman primates. Neurological Res. 1988; 10: 184-192.
72. Halsey JH, Conger KA, Hudetz AG, Hobbes FMG, Garcia JH, Strong ER. The role of tissue acidosis in ischaemic tissue injury: the concept of the pH integral. Neurol Res . 1988; 10: 97-104.
73. Halsey JH, McDowell HA, Gelman S, Morawetz R. Blood velocity in the middle cerebral artery and regional cerebral blood flow during carotid endarterectomy. Stroke. 1989; 20: 53-58.
74. Formby C, Thomas RG, Halsey JH. Regional cerebral blood flow for singers and nonsingers while speaking, singing, and humming a rote passage. Brain and Language. 1989; 36: 690-698.
75. Burker E, Hannay JH, Halsey JH. Neuropsychological functioning and personality characteristics of migrainous and nonmigrainous female college students. Neuropsychology. 1989; 3: 61-73.
76. Anderson ML, Smith DS, Nioka S, Subramanian H, Garcia JH, Halsey JH. Experimental brain ischemia: assessment of injury by magnetic resonance spectroscopy and histology. Neurol Res. 1990; 12: 195-204.
77. Halsey JH. The effect of emitted power on waveform intensity in transcranial doppler. Stroke. 1990; 21: 1573-1578.
78. Halsey JH, Conger KA, Garcia JH, Sarvary E. The Contribution of reperfusion level to ischemic brain damage. J CBF Metabol. 1991; 11: 994-1000.
79. Zampella E, Morawetz RB, McDowell HA, et al. The importance of cerebral ischemia during carotid endarterectomy. Neurosurg. 1991; 29: 727-731.
80. McDowell HA, Gross GM, Halsey JH. Carotid endarterectomy monitored by transcranial Doppler. Ann Surg. 1992; 215: 514-519.
81. Halsey JH. For the International Transcranial Doppler Collaborators. The risks and benefits of shunting in carotid endarterectomy. Stroke. 1992; 23: 1583-1587.
82. Conger KA, Halsey JH, Luo KL, Tan MJ, Pohost GM, Hetherington H. Concomitant EEG, lactate, and phosphorus changes by 1H and 31P NMR Spectroscopy during repeated brief cerebral ischemia. JCBF Metabol. 1995; 115: 26-32.
83. Halsey JH. Vasospasm Monitored by Transcranial Doppler. Neuro Open J. 2014; 1(1): e1. 10.17140/NOJ-1-e001

Walaa F Alsanie, PhD

Lecturer
Department of Internal Medicine
Faculty of Medicine
Taif University
Saudi Arabia

BiographyResearch InterestScientific ActivitiesPublications

Mr. Alsanie is a scientist at the Florey Institute of Neuro science and Mental Health, (The University of Melbourne, Australia) where he is currently finishing his PhD. Mr. Alsanie received his Masters degree with distinction in Laboratory Medicine from RMIT University, Australia. Mr. Alsanie completed his Bachelor degree in Laboratory Medicine at the faculty of Medicine, Um-Alqura University, Saudi Arabia. He then worked at the Faculty of Medicine, served as Lecturer in the department of Pharmacology, and a researcher at Taif Stem Cell Research Institute, Taif University, Saudi Arabia. Mr. Alsanie has authored and reviewed several publications in various journals. His publications reflect are research interests in pluripotent stem cells differentiation towards different neural lineages, for the purpose of transplantation, disease modelling and drug testing. Mr. Alsanie is a member in the Australas in Neuro science Society, Stem Cells Australia and the Australasian Society for Stem Cell Research.

His research interests include: Investigating the Potential of Pluripotent stem cell based therapies in different Neurological disorders, such as Parkins on disease and Spinal cord injury.

SCHOLARSHIPS, AWARDS AND ACHIEVEMENTS


• (2014) The National Stem Cell Foundation of Australia (NSCFA) travel award
• (2014) Editorial board member The Journal of Regenerative Medicine; IF = 3.873
• (2014) Editorial board member The Journal of Stem Cells Research, Reviews & Reports
• (2013) Submission of issues cover (issue#18) for The Journal of Stem Cells and Development by invitation IF=4.670
• (2011) PhD Scholarship, granted by the Saudi Arabian government
• (2010) Member of The International Golden Key Honour Society, the membership granted by invitation based on the achievements during the Master degree
• (2008) Master Scholarship, granted by Saudi Arabian government

Scientific Publications


1. Fernando C, Kele J, Bye C, et al. Diverse roles for Wnt7a in ventral midbrain neurogenesis and dopaminergic axon morphogenesis. Stem Cells and Development. 2014. doi: 10.1089/scd.2014.0166
2. Alsanie W, Niclis JC, Petratos S. Human embryonic stem cell derived oligodendrocytes: Protocols and Perspectives. Stem Cells and Development. 2013; 22(18): 2459-2476. doi: 10.1089/scd.2012.0520
3. Niclis JC, Pinar A, Haynes JM, et al. Characterisation of forebrain neurons derived from late-onset Huntingtons Disease human embryonic stem cell lines. Frontiers in Cellular Neuroscience. 2013; 7: 1-13. doi: 10.3389/fncel.2013.00037

Jaikishan Jayakumar, PhD

Research Officer
National Health and Medical research council (NHMRC)
Visual and Cognitive Neuroscience Laboratory
Department of Optometry and Vision Science
Melbourne Brain Centre, The University of Melbourne
7 Archibald chase, Point Cook, Victoria 3030
Melbourne, Australia

BiographyResearch InterestScientific ActivitiesPublications

Dr. Jayakumar is a Research Fellow at the Department of Optometry and Vision Sciences, The University of Melbourne, Australia. After completing his BS in Optometry from the Birla Institute of Techonology and Science, India and Bachelor of Computer Applications from the University of Madras, India, Dr. Jayakumar completed his doctoral training (PhD) at the University of New South Wales, Australia. He is currently pursuing his research interests in visual neuroscience, studying the organization of the visual system at the University of Melbourne.

His research interests include: Neurobiology of Vision, Sensory systems, Colour vision, Neurobiology of feedback pathways and their contribution to complex tasks such as Attention, Corneal physiology and Contact lenses.

AWARDS


• University International Post-graduate Research Scholarship (UIPRS) from the University of New South Wales
• Best Contact lens related project award at the Elite school of Optometry

Articles


1. Jayakumar J, Roy S, Dreher B, Martin PR, Vidyasagar TR. Multiple pathways carry signals from short wavelengths-sensitive ("blue") cones to the middle temporal (MT) area of the macaque. J Physiol (London). 2013; 591: 339-352. doi: 10.1113/jphysiol.2012.241117
2. Maloney RT, Jayakumar J, Levichkina E, Pigarev IN, Vidyasagar TR. Attentional blink and a neural correlate for it in the macaques parietal cortex. Experimental Brain research. 2013; 228: 365-376.
3. Jayakumar J, Dreher B, Vidyasagar TR. Tracking blue cone signals in the primate brain. Clin Exp Optom. 2013; 96: 259-266. doi: 10.1111/j.1444-0938.2012.00819.x
4. Jayakumar J, Hu D, Vidyasagar TR. Sparseness of coding in area 17 of the cat visual cortex: A comparison between pinwheel centres and orientation domains. Neuroscience. 2012; 225: 55-64. doi: 10.1016/j.neuroscience.2012.08.064
5. Viswanathan S, Jayakumar J, Vidyasagar TR. Role of feedforward geniculate inputs in the generation of orientation selectivity in the cats primary visual cortex. J Physiol (London). 2011; 589: 2349-2361. doi: 10.1113/jphysiol.2010.202317
6. Vidyasagar TR, Jayakumar J, Viswanathan S. How does the visual brain code contours. Physiology news. 2011.
7. Roy S, Jayakumar J, Martin PR, et al. Segregation of short-wavelength sensitive cone signals in the macaque dorsal lateral nucleus. Eur J Neurosci. 2009; 30: 1517-1526. doi: 10.1111/j.1460-9568.2009.06939.x.
8. Jayakumar J, Swarbrick HA. The effect of age on short-term orthokeratology. Optom Vis Sci. 2005; 82: 505-511. doi: 0.1097/01.opx.0000168583.17327.6d
9. Webster SM, Webster MA, Taylor J, Jayakumar J, Verma R. Simultaneous Blur Contrast. Human Vision and Electronic Imaging VI: Proceedings of SPIE. 2001; 4299: 414-422. doi: 10.1117/12.429511
10. Webster MA, Webster SM, Bharadwaj S, et al. Variations in normal color vision III. Unique hues in Indian and US observers. J Opt Soc Am A. 2001; 19: 1951-1962. doi: http://dx.doi.org/10.1364/JOSAA.19.001951
11. Jayakumar J. Blue cone signals in the extra striate cortex: explanation for blind sight? Neuro Open J. 2015; 2(1): e2-e3. doi: 10.17140/NOJ-2-e002

Parisa Farzanehfar, MD

Florey Institute of Neuroscience and Mental Health
University of Melbourne
Parkville, Vic 3010
Australia

BiographyResearch InterestScientific ActivitiesPublications

Dr. Farzanehfar was graduated in 2010 from Isfahan University of Medical Sciences, Iran. After completing her medicine studies, she joined the Florey Institute of Neuroscience and Mental Health, Melbourne, Australia in 2012 to start her PhD in neuroscience. She is currently working on adult midbrain neurogenesis in context of Parkinsons disease.

Her research interests include: Parkinsons disease, Adult neurogenesis and Stem cell therapy.

AWARDS AND HONORS


• Ranked as the top graduated student among 150 classmates (2010)
• Successfully submitted the Doctorate of Medicine thesis with score of 19.03 out of 20 (high distinction)
• Awarded the degree of medical doctor with high distinction (7-year curriculum) in (2010)
• Selected as the talented student of the year by Isfahan University of Medical Sciences, (2010)
• Australian Postgraduate Award (APA) recipient by University of Melbourne, (Mar 2013)
• Awarded by trustees of the Bethlehem Griffiths Research Foundation for services to medical research, (Aug 2013)
• Winner of First Prize Award for the best poster presentation in Students of Brain Research (SOBR) symposium, (Oct 2013)
• Winner of the Sir Grafton Elliot-Smith Poster Award in Australian Neuroscience Society (ANS) conference (2014)
• Participant of Advanced Research Workshop in Neuroscience 2014 Human Pluripotent Stem Cells in Neuroscience Research


MEMBERSHIPS


• Medical Council, IR Iran since 2010
• Australian Neuroscience Society (ANS) since 2014

1. Poster presentation in Brain Research SOBR symposium. 2013.
2. Poster presentation in Australian Neuroscience Society (ANS) conference 2014, University of Adelaide.
3. Poster presentation in Cell Reprogramming Australia Inc. 2nd Annual Collaborative Conference. University of Melbourne. 2014.
4. Poster presentation in Brain Research SOBR symposium. 2014.
5. Oral presentation in European Molecular Biology Laboratory (EMBL) Australia PhD Symposium. UNSW. 2014.

Gokul Krishna, PhD

Postdoctoral Fellow
Department of Integrative Biology and Physiology
University of California Los Angeles
Los Angeles, USA

BiographyResearch InterestScientific ActivitiesPublications

Dr. Gokul Krishna is a Postdoctoral Fellow at the Department of Integrative Biology and Physiology, University of California Los Angeles, Los Angeles. His research examines how the lifestyle factors influences neuroplasticity and consequently a variety of behaviors.

His research focus includes; (1) effects of exercise/or dietary factors during brain homeostasis and after injury; (2) mechanisms by which environmental stressors modulate neurodevelopment and contribute to neurotoxicity; (3) exploring the biological mechanisms responsible altered brain functioning with a focus on behavioral outcomes and their underlying neurochemical mechanisms; (4) oxidative dysfunctions within the brain that cause neuronal death and contribute to the onset and progression of neurodegenerative diseases.

HONORS, AWARDS AND AFFILIATIONS

2015 International Association of Parkinsonism and Related Disorders and Melvin Yahr International Parkinson’s Disease Foundation
2014 World Federation of Neurology (WFN) Travel Fellowship


PROFESSIONAL AFFILIATIONS

2014 Member, Commonwealth Pharmacists Association
2009 Member, Indian Pharmacological Society, India
2007 Registered Pharmacist, State Pharmacy Council, Karnataka, India


EDITORIAL ACTIVITIES

Journal of Disease Markers (Reviewer)
International Journal of Food and Nutrition (Reviewer)

1. Divyashri G, Krishna G, Muralidhara and Prapulla SG. Probiotic attributes, antioxidant, anti-inflammatory and neuromodulatory effects of probiotic Enterococcus faecium CFR 3003: In vitro and in vivo evidences. Journal of Medical Microbiology 2015;64(12):1527-40.
2. Krishna G, Divyashri G, Prapulla G and Muralidhara. A combination supplement of fructo- and xylo-oligosaccharides significantly abrogates oxidative impairments and neurotoxicity in maternal/fetal milieu following gestational exposure to acrylamide in rat. Neurochemical Research 2015;40(9):1904-18.
3. Krishna G and Muralidhara. Aqueous extract of tomato seeds attenuate rotenone-induced oxidative stress and neurotoxicity in Drosophila melanogaster. Journal of the Science of Food and Agriculture (doi: 10.1002/jsfa.7281).
4. Krishna G and Muralidhara. Inulin supplementation during gestation mitigates acrylamide-induced maternal and fetal brain oxidative dysfunctions and neurotoxicity in rats. Neurotoxicology and Teratology 2015;49:49-5.
5. Hani U, Krishna G, Shivakumar HG, Srivastava A. Design and optimization of clotrimazole-hydroxypropyl-B-cyclodextrin bioadhesive vaginal tablets using Anacardium occidentale gum by 32 factorial design. RSC Advances 2015;5:35391-404.
6. Gokul K and Muralidhara. Oral supplements of aqueous extract of tomato seeds alleviate motor abnormality, oxidative impairments and neurotoxicity induced by rotenone in mice: Relevance to Parkinson’s disease. Neurochemical Research 2014;39(7):1382-94.
7. Hosamani R, Krishna G and Muralidhara. Standardized Bacopa monnieri extract ameliorates acute paraquat-induced oxidative stress, and neurotoxicity in prepubertal mice brain. Nutritional Neuroscience (DOI: 10.1179/1476830514Y.0000000149).

Francesca Guida, PhD

Researcher
Department of Experimental Medicine
Division of Pharmacology
Second University of Naples
Naples, Italy

BiographyResearch InterestScientific ActivitiesPublications
EDUCATION


• (2009-2015) Neuropharmacology (Post-Doc) Second University of Naples, Italy
• (2007-2009) Pharmacology (PhD) Second University of Naples, Italy, Kings College, London, UK
• (2005) Pharmacy, University of Naples Federico II, Italy

His research interest include: Pain, Behaviour, Glia.

• (2016) “Premio Società Italiana di Farmacologia- Farmindustria per Ricerche Farmacologiche” 2015, award
• (2016) Research Scientist- Second University of Naples, Italy
• (2013) Research collaboration- Second University of Naples, Italy
• (2012) Post-doctoral position- Pharmacological Sciences, Second University of Naples, Italy
• (2009) PhD- Pharmacological Sciences, Second University of Naples, Italy
• (2008) Italian Society of Pharmacology member

1. Peduto A, Krauth V, Collarile S, et al. Exploring the role of chloro and methyl substitutions in 2-phenylthiomethyl-benzoindole derivatives for 5-LOX enzyme inhibition. Eur J Med Chem. 2016; 108: 466-475. doi: 10.1016/j.ejmech.2015.11.048
2. Aiello F, Badolato M, Pessina F, et al. Design and Synthesis of New Transient Receptor Potential Vanilloid Type-1 (TRPV1) Channel Modulators: Identification, Molecular Modeling Analysis, and Pharmacological Characterization of the N-(4-Hydroxy-3-methoxybenzyl)-4-(thiophen-2-yl)butanamide, a Small Molecule Endowed with Agonist TRPV1 Activity and Protective Effects against Oxidative Stress. ACS Chem Neurosci. 2016; 7(6): 737-748. doi: 10.1021/acschemneuro.5b00333
3. Moriello AS, Luongo L, Guida F, et al. Chalcone derivatives activate and desensitize the transient receptor potential ankyrin 1 cation channel, subfamily A, member 1 TRPA1 ion channel: structure-activity relationships in vitro and anti-nociceptive and anti-inflammatory activity in vivo. CNS Neurol Disord Drug Targets. 2016. Web site. http://europepmc.org/abstract/med/27071783. Accessed
4. Palazzo E, Luongo L, Guida F, Marabese I, Romano R, Iannotta M, Rossi F, D Aniello A, Stella L, Marmo F, Usiello A, de Bartolomeis A, Maione S, de Novellis V. D-Aspartate drinking solution alleviates pain and cognitive impairment in neuropathic mice. Amino Acids. 2016; 48(7): 1553-1567. doi: 10.1007/s00726-016-2205-4
5. Guida F, Luongo L, Marmo F, et al. Palmitoylethanolamide reduces pain-related behaviors and restores glutamatergic synapses homeostasis in the medial prefrontal cortex of neuropathic mice. Mol Brain. 2015; 8: 47. doi: 10.1186/s13041-015-0139-5
6. Rinaldi B, Guida F, Furiano A, Donniacuo M, Luongo L, Gritti G, Urbanek K, Messina G, Maione S, Rossi F, de Novellis V. Effect of Prolonged Moderate Exercise on the Changes of Nonneuronal Cells in Early Myocardial Infarction. Neural Plast. 2015; 2015: 265967. doi: 10.1155/2015/265967
7. Sagheddu C, Aroni S, De Felice M, et al. Enhanced serotonin and mesolimbic dopamine transmissions in a rat model of neuropathic pain. Neuropharmacology. 2015; 97: 383-393. doi: 10.1016/j.neuropharm.2015.06.003
8. Spaziano G, Luongo L, Guida F, et al. Exposure to Allergen Causes Changes in NTS Neural Activities after Intratracheal Capsaicin Application, in Endocannabinoid Levels and in the Glia Morphology of NTS. Biomed Res Int. 2015; 2015: 980983. doi: 10.1155/2015/980983
9. Guida F, Lattanzi R, Boccella S, et al. PC1, a non-peptide PKR1-preferring antagonist, reduces pain behavior and spinal neuronal sensitization in neuropathic mice. Pharmacol Res. 2015, 91: 36-46. doi: 10.1016/j.phrs.2014.11.004
10. Boccella S, Vacca V, Errico F, et al. D-aspartate modulates nociceptive-specific neuron activity and pain threshold in inflammatory and neuropathic pain condition in mice. Biomed Res Int. 2015; 2015: 90590. doi: 10.1155/2015/905906
11. Luongo L, Guida F, Imperatore R, et al. The A1 adenosine receptor as a new player in microglia physiology. Glia. 2014; 62(1): 122-132. doi: 10.1002/glia.22592
12. Stella L, Guida F, Nava E, et al. Evaluation and cost analysis in two groups of patients who had been randomized for toxicological monitoring. Heroin Addiction and Related Clinical Problems. 2014; 4(57-62).
13. Rossi F, Bernardo ME, Bellini G, et al. The cannabinoid receptor type 2 as mediator of mesenchymal stromal cell immunosuppressive properties. PLoS One. 2013; 8(11): e80022. doi: 10.1371/journal.pone.0080022
14. Ligresti A, Martos J, Wang J, et al. Prostamide F 2α receptor antagonists with inhibitory activity at FAAH: a way to prevent the confounding effects of pro-inflammatory mediators formed following selective FAAH inhibition? Br J Pharmacol. 2013.
15. Rossi F, Bellini G, Torella M, et al. The genetic ablation or pharmacological inhibition of TRPV1 signaling is beneficial in the restoration of quiescent osteoclast activity in ovariectomized mice. Br J Pharmacol. 2013; 171(10): 2621-2630. doi: 10.1111/bph.12542
16. 16. Rossi F, Marabese I, De Chiaro M, et al. Dorsal striatum metabotropic glutamate receptor 8 affects nocifensive responses and rostral ventromedial medulla cell activity in neuropathic pain conditions. J Neurophysiol. 2013; 111(11): 2196-2209. doi: 10.1152/jn.00212.2013
17. Maione S, Costa B, Piscitelli F, et al. Piperazinyl carbamate fatty acid amide hydrolase inhibitors and transient receptor potential channel modulators as "dual-target" analgesics. Pharmacol Res. 2013; 76: 98-105. doi: 10.1016/j.phrs.2013.07.003
18. Descalzi F, Ulivi V, Cancedda R, et al. Platelet-rich plasma exerts antinociceptive activity by a peripheral endocannabinoid-related mechanism. Tissue Eng Part A. 2013; 19(19-20): 2120-2129. doi: 10.1089/ten.TEA.2012.0557
19. Caraglia M, Luongo L, Salzano G, et al. Stealth liposomes encapsulating zoledronic acid: a new opportunity to treat neuropathic pain. Mol Pharm. 2013; 10(3): 1111-1118. doi: 10.1021/mp3006215
20. Luongo L, Guida F, Boccella S, et al. Palmitoylethanolamide Reduces Formalin-Induced Neuropathic-Like Behaviour Through Spinal Glial/Microglial Phenotypical Changes in Mice. CNS Neurol Disord Drug Targets. 2013; 12(1): 45-54. doi: 10.2174/1871527311312010009
21. . Citraro R, Russo E, Scicchitano F, et al. Antiepilepticaction of N-palmitoylethanolaminethrough CB1 and PPAR-α receptor activation in a genetic model of absence epilepsy. Neuropharmacology. 2013; 69: 115-126. doi: 10.1016/j.neuropharm.2012.11.017
22. Luongo L, Petrelli R, Gatta L, et al. 5-Chloro-5-deoxy-ENBA, a Potent and Selective Adenosine A1 ReceptorAgonist, Alleviates NeuropathicPain in Mice Through Functional Glial and Microglial Changes without Affecting Motor or Cardiovascular Functions. Molecules. 2012; 17(12): 13712-13726. doi: 10.3390/molecules171213712
23. Rossi F, Bellini G, Luongo L, et al. The 17-β-oestradiolinhibitsosteoclastactivity by increasing the cannabinoid CB2 receptor expression. Pharmacol Res. 2012; 68(1): 7-15. doi: 10.1016/j.phrs.2012.10.017
24. Guida F, Luongo L, Aviello G, et al. A reduces mechanical allodynia and spinal neuronal hyperexcitability induced by peripheral formalin injection. Mol Pain. 2012; 8: 60. doi: 10.1186/1744-8069-8-60
25. Luongo L, de Novellis V, Gatta L, et al. Role of metabotropic glutamate receptor 1 in the basolateral amygdala-driven prefrontal cortical deactivation in inflammatory pain in the rat. Neuropharmacology. 2012; 66: 317-329. doi: 10.1016/j.neuropharm.2012.05.047
26. Luongo L, Costa B, D-Agostino B, at al. Palvanil, a non-pungent capsaicin analogue, inhibits inflammatory and neuropathic pain with little effects on bronchopulmonary function and body temperature. Pharmacol Res. 2012; 66(3): 243-250. doi: 10.1016/j.phrs.2012.05.005
27. Pasquini S, Mugnaini C, Ligresti A, et al. Design, Synthesis, and Pharmacological Characterization of Indol-3-ylacetamides, Indol-3-yloxoacetamides, and Indol-3-ylcarboxamides: Potent and Selective CB2 Cannabinoid Receptor Inverse Agonists. J MedChem. 2012; 55(11): 5391-5402. doi: 10.1021/jm3003334
28. Palazzo E, Luongo L, Bellini G, et al. Changes in cannabinoid receptor subtype 1 activity and interaction with metabotropic glutamate subtype 5 receptors in the periaqueductal gray-rostral ventromedial medulla pathway in a rodent neuropathic pain model.CNS Neurol Disord Drug Targets. 2012; 11(2): 148-161. doi: 10.2174/187152712800269731
29. Mugnaini C, Nocerino S, Pedani V, et al. Investigations on the 4-quinolone-3-carboxylic acid motif part 5: modulation of the physicochemical profile of a set of potent and selective cannabinoid-2 receptor ligands through a bioisosteric approach. ChemMedChem. 2012; 7(5): 920-934. doi: 10.1002/cmdc.201100573
30. Lattanzi R, Sacerdote P, Franchi S, et al. Pharmacological activity of a Bv8 analogue modified in position 24. Br J Pharmacol. 2012; 166(3): 950-963. doi: 10.1111/j.1476-5381.2011.01797.x
31. de Novellis V, Luongo L, Guida F, et al. Effects of intra-ventrolateral periaqueductal grey palmitoylethanolamide on thermoceptive threshold and rostral ventromedial medulla cell activity. Eur J Pharmacol. 2012; 676(1-3): 41-50. doi: 10.1016/j.ejphar.2011.11.034
32. Palazzo E, Guida F, Gatta L, et al. EP1 receptor within the ventrolateral periaqueductal grey controls thermonociception and rostral ventromedial medulla cell activity in healthy and neuropathic rat. Mol Pain. 2011; 7: 82. doi: 10.1186/1744-8069-7-82
33. De Petrocellis L, Guida F, Moriello AS, et al. N-palmitoyl-vanillamide (palvanil) is a non-pungent analogue of capsaicin with stronger desensitizing capability against the TRPV1 receptor and anti-hyperalgesic activity. Pharmacol Res. 2011; 63(4): 294-299. doi: 10.1016/j.phrs.2010.12.019
34. Soukupova M, Palazzo E, Chiaro MD, et al. Effects of URB597, an inhibitor of fatty acid amide hydrolase (FAAH), on analgesic activity of paracetamol. Neuro EndocrinolLett. 2010; 31(4): 507-511. Web site. http://europepmc.org/abstract/med/20802454. Accessed
35. Pasquini S, De Rosa M, Pedani V, et al. Investigations on the 4-quinolone-3-carboxylic acid motif. 4. Identification of new potent and selective ligands for the cannabinoid type 2 receptor with diverse substitution patterns and antihyperalgesic effects in mice. J Med Chem. 2011; 54(15): 5444-5453. doi: 10.1021/jm200476p
36. Aviello G, Borrelli F, Guida F, et al. Capasso R Ultrapotent effects of salvinorin A, a hallucinogenic compound from Salvia divinorum, on LPS-stimulated murine macrophages and its anti-inflammatory action in vivo. J Mol Med. 2011; 89(9): 891-902. doi: 10.1007/s00109-011-0752-4
37. Pasquini S, Ligresti A, Mugnaini C, et al. Investigations on the 4-quinolone-3-carboxylic acid motif. 3. Synthesis, structure-affinity relationships, and pharmacological characterization of 6-substituted 4-quinolone-3-carboxamides as highly selective cannabinoid-2 receptor ligands. J Med Chem. 2010; 53(16): 5915-5928. doi: 10.1021/jm100123x
38. Clark AK, Wodarski R, Guida F, Sasso O, Malcangio M. Cathepsin S release from primary cultured microglia is regulated by the P2X7 receptor. Glia. 2010; 58(14): 1710-1726. doi: 10.1002/glia.21042
39. Palazzo E, Rimoli MG, De Chiaro M, et al. Intra-periaqueductal grey microinjections of an imidazo [1,2-b] pyridazine derivative, DM2, affects rostral ventromedial medulla cell activity and shows antinociceptive effect. Neuropharmacology. 2009; 58(3): 660-667. doi: 10.1016/j.neuropharm.2009.11.006
40. Palazzo E, Guida F, Migliozzi A, et al. Intra-Periaqueductal Gray glycine decreases or increases the activity of Rostral Ventromedial Medulla ON and OFF cell respectively and enhances thermoceptive threshold in the rat. J Neurophysiol. 2009; 102(6): 3169-3179.
41. Brizzi A, Brizzi V, Cascio MG, et al. New resorcinol-anandamide "hybrids" as potent cannabinoid receptor ligands endowed with antinociceptive activity in vivo. J MedChem. 2009; 52(8): 2506-2514. doi: 10.1021/jm8016255
42. Maione S, Starowicz K, Cristino L, et al. Functional Interaction Between TRPV1 and {micro}-Opioid Receptors in the Descending Antinociceptive Pathway Activates Glutamate Transmission and Induces Analgesia. J Neurophysiolo. 2009; 101(5): 2411-2422. doi: 10.1152/jn.91225.2008
43. Palazzo E, Rossi F, De Petrocellis L, et al. The analgesic effect of N-arachidonoyl-serotonin, a FAAH inhibitor and TRPV1 receptor antagonist, associated with changes in rostral ventromedial medulla and locus coeruleus cell activity in rats. Neuropharmacology. 2008; 55(7): 1105-1113. doi: 10.1016/j.neuropharm.2008.06.023
44. Marabese I, Rossi F, Palazzo E, de Novellis V, Starowicz K, Cristino L, Vita D, Gatta L, Guida F, Di Marzo V, Rossi F, Maione S. Periaqueductal gray metabotropic glutamate receptor subtype 7 and 8 mediate opposite effects on amino acid release, rostral ventromedial medulla cell activities, and thermal nociception. J Neurophysiol. 2007; 98(1): 43-53. doi: 10.1152/jn.00356.2007

John F. Bebawy, MD

Associate Professor
Department of Anesthesiology and Neurological Surgery
Northwestern University Feinberg School of Medicine
251 E. Huron St., Suite F5-704
Chicago, Illinois 60611, USA

BiographyResearch InterestScientific ActivitiesPublications

Dr. Bebawy, MD is an Associate Professor of Anesthesiology & Neurological Surgery at Northwestern University. His clinical and research interests and expertise relate to Neuroanesthesia, with a focus on interventions that affect cerebral blood flow and cerebrovascular hemodynamics. Dr. Bebawy completed his Anesthesiology residency and Neurosurgical Anesthesiology fellowship training at Northwestern in 2008, where he is currentlyfaculty, Associate Director of the Neurosurgical Anesthesiology Fellowship Program, and Director of Neurosurgical Anesthesia Education. He is a member of many national and international societies for the advancement of Neurosurgical Anesthesiology, has published widely on various topics in the field, and has spoken at many meetings throughout the world on areas within his expertise. Dr. Bebawy is devoted and committed to the betterment of patient safety through individualized and compassionate clinical care, as well as through his contribution to the scientific community.

His research interests include: Neuroanesthesia, Cerebral blood flow, Cerebral physiology, Cerebral pharmacology, Adenosine, Circulatory arrest, Post-craniotomy hypertension and Awake craniotomy.

HONORS AND AWARDS


• (September 1998) F. Edward Hébert Armed Forces Health Professions Scholarship
• (November 2007) Goldberg Charitable Trust Foundation Scholarship (Luzern, Switzerland)
• (October 2008) Society of Neurosurgical Anesthesia and Critical Care Resident Travel Award (Orlando, Florida)
• (August 2013) Melissa FragenFaculty Development Research Award
• (2016) Americas Best Physicians, National Consumer Advisory Board


PROFESSIONAL MEMBERSHIPS


• (2001-Present) American Medical Association
• (2002-Present) American Society of Anesthesiologists
• (2003-Present) International Anesthesia Research Society
• (2004-Present) Illinois Society of Anesthesiologists
• (2005-Present) Chicago Society of Anesthesiologists
• (2007-Present) Society for Neuroscience in Anesthesiology and Critical Care
• (2008-Present) American Society of Neurophysiological Monitoring
• (2008-Present) Asian Society of Neuroanesthesia and Critical Care

ORIGINAL INVESTIGATIONS


1. Bebawy JF, Gupta DK, Cotton MA, et al. Alternative anterior reference sites for measuring posterior tibial nerve somatosensory evoked potentials. J Clin Monit Comput. 2010; 24(2): 107-111. doi: 10.1007/s10877-009-9216-6.
2. Bebawy JF, Gupta DK, Bendok BR, et al. Adenosine-induced flow arrest to facilitate intracranial aneurysm clip ligation: Dose-response data and safety profile. Anesth Analg. 2010; 110(5): 1406-1411. doi: 10.1213/ANE.0b013e3181d65bf5
3. Lin N, Bebawy JF, Hua L, Wang B. Is L2-L3 interspace spinal anaesthesia safe in disorders of the vertebral column? A magnetic resonance imaging study. Br J Anaesth. 2010; 105(6): 857-862. doi: 10.1093/bja/aeq246
4. Bendok BR, Gupta DK, Rahme RJ, et al. Adenosine for temporary flow arrest during intracranial aneurysm surgery: A single center retrospective review. Neurosurgery. 2011; 69(4): 815-821. doi: 10.1227/NEU.0b013e318226632c
5. Bebawy JF, Ramaiah VK, Zeeni C, Hemmer LB, Koht A, Gupta DK. The effect of furosemide on intravascular volume status and electrolytes in patients receiving mannitol: An intraoperative safety analysis. J Neurosurg Anesthesiol. 2013; 25(1): 51-54. doi: 10.1097/ANA.0b013e318269c335.
6. Bebawy JF, Zeeni C, Sharma S, et al. Adenosine-induced flow arrest to facilitate intracranial aneurysm clip ligation does not worsen neurologic outcome. Anesth Analg. 2013; 117(5): 1205-1210. doi: 10.1213/ANE.0b013e3182a6d31b
7. Sharma D, Bilotta F, Moore LE, et al. Web-based educational activities developed by the Society for Neuroscience in Anesthesiology and Critical Care (SNACC): The experience of process, utilization, and expert evaluation. J Neurosurg Anesthesiol. 2014; 26(1): 4-10. doi: 10.1097/ANA.0b013e31829cf903
8. Hemmer LB, Zeeni C, Bebawy JF, et al. The incidence of unacceptable movement with motor evoked potentials during craniotomy for aneurysm clipping. World Neurosurg. 2014; 81(1): 99-104. doi: 10.1016/j.wneu.2012.05.034
9. Carabini LM, Zeeni C, Moreland NC, et al. Development and validation of a generalizable model for predicting major transfusion during spine fusion surgery. J Neurosurg Anesthesiol. 2014; 26(3): 205-215. doi: 10.1097/ANA.0000000000000014
10. Carabini LM, Zeeni C, Moreland NC, et al. Predicting major adverse cardiac events in spine fusion patients: Is the Revised Cardiac Risk Index sufficient? Spine (Phila Pa 1976). 2014; 39(17): 1441-1448. doi: 10.1097/BRS.0000000000000405
11. Zeeni C, Carabini LM, Gould RW, et al. The implementation and efficacy of the Northwestern High Risk Spine Protocol. World Neurosurg. 2014; 82(6): e815-e823. doi: 10.1016/j.wneu.2014.06.020
12. Carabini LM, Navarre WJ, Ault ML, Bebawy JF, Gupta DK. A comparison of hemoglobin measured by co-oximetry and central laboratory during major spine fusion surgery. Anesth Analg. 2015; 120(1): 60-65. doi: 10.1213/ANE.0000000000000418
13. Bebawy JF, Houston CC, Kosky JL, et al. Nicardipine is superior to esmolol for the management of post-craniotomy emergence hypertension: A randomized open-label study. Anesth Analg. 2015; 120(1): 186-192. doi: 10.1213/ANE.0000000000000473
14. Lin N, Li Y, Bebawy JF, Dong J, Hua L. Abdominal circumference but not the degree of lumbar flexion affects the accuracy of lumbar interspace identification by Tuffier’s line palpation method: An observational study. BMC Anesthesiol. 2015; 15(1): 9. doi: 10.1186/1471-2253-15-9


REVIEWS, CASE REPORTS, LETTERS, EDITORIALS


1. Bebawy JF, Koht A. Review: Cottrell and Young’s Neuroanesthesia. Anesth Analg. 2011; 112(2): 488-489.
2. Bebawy JF, Gupta DK, Koht A. Compartment syndrome caused by a properly functioning infusion pump. J Clin Anesth. 2011; 23(2): 134-136. doi: 10.1016/j.jclinane.2009.11.006
3. Bebawy JF. Rocuronium bromide. Anesthesiology. 2011; 114(6): 1486.
4. Bebawy JF. State of the art. Anesthesiology. 2011; 114(6): 1487.
5. Rahme RJ, Adel JG, Bendok BR, Bebawy JF, Gupta DK, Batjer HH. Association of intracranial aneurysm and Loeys-Dietz Syndrome: Case illustration, management, and literature review. Neurosurgery. 2011; 69(2): 488-493. doi: 10.1227/NEU.0b013e318218cf55
6. Bebawy JF, Ramaiah VK, Hemmer LB, Gupta DK. Clinical pharmacology of insulin confounds stroke trials. Ann Neurol. 2012; 71(1): 148-149. doi: 10.1002/ana.22377
7. Bebawy JF. Perioperative steroids for peritumoral intracranial edema: A review of mechanisms, efficacy, and side effects. J Neurosurg Anesthesiol. 2012; 24(3): 173-177. doi: 10.1097/ANA.0b013e3182578bb5.
8. Bendok BR, El Tecle N, El Ahmadieh TY, et al. Comment on: Surgical treatment of 127 anterior choroidal artery aneurysms: A cohort study of resultant ischemic complications. Neurosurgery. 2013; 73(6): 939-940. doi: 10.1227/NEU.0000000000000131
9. Bebawy JF, Bilotta F, Koht A. A modified technique for auriculotemporal nerve blockade when performing selective scalp nerve block for craniotomy. J Neurosurg Anesthesiol. 2014; 26(3): 271-272. doi: 10.1097/ANA.0000000000000032
10. Bebawy JF, Gupta DK. In response. Anesth Analg. 2015; 121(5): 1399-1400.


BOOKS AND BOOK CHAPTERS


1. Zeeni C, Bebawy JF, Gupta DK, Koht A. Anesthesia considerations for neurovascular surgery. In: Bendok BR, Batjer HH, Naidech AM, Walker MT, eds. Hemorrhagic and Ischemic Stroke: Medical, Imaging, Surgical, and Interventional Approaches. 1st ed. New York, NY, USA: Thieme; 2012: 171-181.
2. Bebawy JF, Koht A, Mirkovic S. Anterior cervical spine surgery. In: Koht A, Sloan TB, Toleikis JR, eds. Monitoring the Nervous System for Anesthesiologists and Other Health Care Professionals. 1st ed. New York, NY, USA: Springer; 2012: 539-554.
3. Bebawy JF, Koht A. Autonomic hyperreflexia. In: Singh-Radcliff N, ed. The 5-Minute Anesthesia Consult. 1st ed. Philadelphia, PA, USA: Lippincott Williams & Wilkins; 2013: 110-111.
4. Bebawy JF, Koht A. Anesthesia for neurosurgery. In: Barash PG, Cullen BF, Stoelting RK, Cahalan MK, Stock MC, Ortega RA, Sharar SR, eds. Clinical Anesthesia Fundamentals. 1st ed. Philadelphia, PA, USA: Lippincott Williams & Wilkins; 2015: 557-576.

Livio Luongo, PhD

Research Scientist
Department of Experimental Medicine
Division of Pharmacology
Second University of Naples
Naples, Italy

BiographyResearch InterestScientific ActivitiesPublications
EDUCATION


• (2008-2012, 2012, London) Neuropharmacology (Post-Doc), Second University of Naples, Italy. Wiliam Harvey, Queen Mary University, London
• 2008 (2006-2007 London) Pharmacology (PhD) Second University of Naples, Italy, King’s College, London
• (2004) Pharmacy University of Naples Federico II, Naples, Italy

RESEARCH INTERST


• Neuron-glia comunications in the development of chronic neurodegenerative diseases
• Neuropathic pain pathophysiology
• New pharmacological tools on microglia cells
• Involvement of endocannabinoid system in the pathophysiology of the chronic neuroinflammatory diseases

1. Palazzo E, Luongo L, Guida F, et al. D-Aspartate drinking solution alleviates pain and cognitive impairment in neuropathic mice. Amino Acids. 2016; 48(7): 1553-1567. doi: 10.1007/s00726-016-2205-4
2. Moriello AS, Luongo L, Guida F, et al. Chalcone derivatives activate and desensitize the transient receptor potential ankyrin 1 cation channel, subfamily A, member 1 TRPA1 ion channel: structure-activity relationships in vitro and anti-nociceptive and anti-inflammatory activity in vivo. CNS Neurol Disord Drug Targets. 2016. Web site. http://europepmc.org/abstract/med/27071783. Accessed
3. Punzo D, Errico F, Cristino L, et al. Age-Related Changes in d-Aspartate Oxidase Promoter Methylation Control Extracellular d-Aspartate Levels and Prevent Precocious Cell Death during Brain Aging. J Neurosci. 2016; 36(10): 3064-3078. doi: 10.1523/JNEUROSCI.3881-15.2016
4. Aiello F, Badolato M, Pessina F, et al. Design and Synthesis of New Transient Receptor Potential Vanilloid Type-1 (TRPV1) Channel Modulators: Identification, Molecular Modeling Analysis, and Pharmacological Characterization of the N-(4-Hydroxy-3-methoxybenzyl)-4-(thiophen-2-yl)butanamide, a Small Molecule Endowed with Agonist TRPV1 Activity and Protective Effects against Oxidative Stress. ACS Chem Neurosci. 2016; 7(6): 737-748. doi: 10.1021/acschemneuro.5b00333
5. Brindisi M, Maramai S, Gemma S, et al. Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain. J Med Chem. 2016; 59(6): 2612-2632. doi: 10.1021/acs.jmedchem.5b01812
6. Cristino L, Luongo L, Imperatore R, et al. Orexin-A and Endocannabinoid Activation of the Descending Antinociceptive Pathway Underlies Altered Pain Perception in Leptin Signalling Deficiency. Neuropsychopharmacology. 2016; 41(2): 508-520. doi: 10.1038/npp.2015
7. Rinaldi B, Guida F, Furiano A, et al. Effect of Prolonged Moderate Exercise on the Changes of Nonneuronal Cells in Early Myocardial Infarction. Neural Plast. 2015; 2015: 265967. doi: 10.1155/2015/265967
8. Guida F, Luongo L, Marmo F, et al. Palmitoylethanolamide reduces pain-related behaviors and restores glutamatergic synapses homeostasis in the medial prefrontal cortex of neuropathic mice. Mol Brain. 2015; 8: 47. doi: 10.1186/s13041-015-0139-5
9. Imperatore R, Morello G, Luongo L, et al. Genetic deletion of monoacylglycerol lipase leads to impaired cannabinoid receptor CB1 R signaling and anxiety-like behavior. J Neurochem. 2015; 135(4): 799-813. doi: 10.1111/jnc.13267
10. Rossi F, Bellini G, Tortora C, et al. CB2 and TRPV1 receptors oppositely modulate in vitro human osteoblast activity. Pharmacol Res. 2015; 99: 194-201. doi: 10.1016/j.phrs.2015.06.010
11. Lorenzo Di Cesare Mannelli, Alessandra Pacini, Francesca Corti,et al. Carla Ghelardini Antineuropathic profile of N-Palmitoylethanolamine in a rat model of oxaliplatin-induced neurotoxicity. Plos One. 2015; 10(6): e0128080. doi: 10.1371/journal.pone.0128080
12. Calzetta L, Luongo L, Cazzola M, et al. Contribution of sensory nerves to LPS-induced hyperresponsiveness of human isolated bronchi. Life Sci. 2015; 131: 44-50. doi: 10.1016/j.lfs.2015.03.023
13. Luongo L, Malcangio M, Salvemini D, Starowicz K. Chronic pain: new insights in molecular and cellular mechanisms. Biomed Res Int. 2015; 2015: 676725. doi: 10.1155/2015/676725
14. Spaziano G, Luongo L, Guida F, et al. Exposure to Allergen Causes Changes in NTS Neural Activities after Intratracheal Capsaicin Application, in Endocannabinoid Levels and in the Glia Morphology of NTS. Biomed Res Int. 2015; 2015: 980983. doi: 10.1155/2015/980983
15. Cristino L, Luongo L, Squillace M, et al. d-Aspartate oxidase influences glutamatergic system homeostasis in mammalian brain. Neurobiol Aging. 2015; 36(5): 1890-1902. doi: 10.1016/j.neurobiolaging.2015.02.003
16. Palazzo E, Romano R, Luongo L, et al. MMPIP, an mGluR7-selective negative allosteric modulator, alleviates pain and normalizes affective and cognitive behavior in neuropathic mice. Pain. 2015; 156(6): 1060-1073. doi: 10.1097/j.pain.0000000000000150
17. Petrelli R, Torquati I, Kachler S, et al. 5-C-Ethyl-tetrazolyl-N(6)-substituted adenosine and 2-chloro-adenosine derivatives as highly potent dual acting A1 adenosine receptor agonists and A3 adenosine receptor antagonists. J Med Chem. 2015; 58(5): 2560-2566. doi: 10.1021/acs.jmedchem.5b00074
18. Lopez-Canul M, Palazzo E, Dominguez-Lopez S, et al. Selective melatonin MT2 receptor ligands relieve neuropathic pain through modulation of brainstem descending antinociceptive pathways. Pain. 2015; 156(2): 305-317. doi: 10.1097/01.j.pain.0000460311.71572.5f
19. Maione S, Radanova L, De Gregorio D, et al. Effects of metabolites of the analgesic agent dipyrone (metamizol) on rostral ventromedial medulla cell activity in mice. Eur J Pharmacol. 2015; 748: 115-122. doi: 10.1016/j.ejphar.2014.12.022
20. Guida F, Lattanzi R, Boccella S, et al. PC1, a non-peptide PKR1-preferring antagonist, reduces pain behavior and spinal neuronal sensitization in neuropathic mice. Pharmacol Res. 2015; 91: 36-46. doi: 10.1016/j.phrs.2014.11.004
21. Little JW, Ford A, Symons-Liguori AM, et al. Endogenous adenosine A3 receptor activation selectively alleviates persistent pain states. Brain. 2015; 138(Pt 1): 28-35. doi: 10.1093/brain/awu330
22. Rossi F, Perrotta S, Bellini G, et al. Iron overload causes osteoporosis in Thalassemia Major patients through interaction with TRPV1 channels. Haematologica. 2014, 99(12): 1876-1884. doi: 10.3324/haematol.2014.104463
23. Maftei D, Marconi V, Florenzano F, et al. Controlling the activation of the Bv8/Prokineticin system reduces neuroinflammation and abolishes thermal and tactile hyperalgesia in neuropathic animals. Br J Pharmacol. 2014, 171(21): 4850-4865. doi: 10.1111/bph.12793
24. Brizzi A, Aiello F, Marini P, et al. Structure-affinity relationships and pharmacological characterization of new alkyl-resorcinol cannabinoid receptor ligands: Identification of a dual cannabinoid receptor/TRPA1 channel agonist. Bioorg Med Chem. 2014; 22(17): 4770-4783. doi: 10.1016/j.bmc.2014.07.006
25. Luongo L, Maione S, Di Marzo V. Endocannabinoids and neuropathic pain: focus on neuron-glia and endocannabinoid-neurotrophin interactions. Eur J Neurosci. 2014; 39(3): 401-408. doi: 10.1111/ejn.12440
26. Rossi F, Bellini G, Torella M, et al. The genetic ablation or pharmacological inhibition of TRPV1 signalling is beneficial for the restoration of quiescent osteoclast activity in ovariectomized mice. Br J Pharmacol. 2014; 171(10): 2621-2630. doi: 10.1111/bph.12542
27. Rossi F, Marabese I, De Chiaro M, et al. Dorsal striatum metabotropic glutamate receptor 8 affects nocifensive responses and rostral ventromedial medulla cell activity in neuropathic pain conditions. J Neurophysiol. 2014; 111(11): 2196-2209. doi: 10.1152/jn.00212.2013
28. Luongo L, Guida F, Imperatore R, et al. The A1 adenosine receptor as a new player in microglia physiology. Glia. 2014; 62(1): 122-132. doi: 10.1002/glia.22592
29. Ligresti A, Martos J, Wang J, et al. Prostamide F(2) α receptor antagonism combined with inhibition of FAAH may block the pro-inflammatory mediators formed following selective FAAH inhibition. Br J Pharmacol. 2014; 171(6): 1408-1419. doi: 10.1111/bph.12410
30. Rossi F, Bernardo ME, Bellini G, et al. The cannabinoid receptor type 2 as mediator of mesenchymal stromal cell immunosuppressive properties. PLoS One. 2013; 8(11): e80022. doi: 10.1371/journal.pone.0080022
31. Palazzo E, Marabese I, Luongo L, et al. Effects of a metabotropic glutamate receptor subtype 7 negative allosteric modulator in the periaqueductal grey on pain responses and rostral ventromedial medulla cell activity in rat. Mol Pain. 2013; 9: 44. doi: 10.1186/1744-8069-9-44
32. De Scalzi F, Ulivi V, Cancedda R, et al. Platelet Rich Plasma exerts antinociceptive activity by a peripheral endocannabinoid-related mechanism. Tissue Eng Part A. 2013 9(19-20): 2120-2129. doi: 10.1089/ten.TEA.2012.0557
33. Luongo L, Guida F, Boccella S, et al. Palmitoylethanolamide reduces formalin-induced neuropathic-like behaviour through spinal glial/microglial phenotypical changes in mice. CNS Neurol Disord Drug Targets. 2013; 12(1): 45-54. doi: 10.2174/1871527311312010009
34. Caraglia M, Luongo L, Salzano G, et al. Stealth liposomes encapsulating zoledronic acid: a new opportunity to treat neuropathic pain. Mol Pharm. 2013, 10(3): 1111-1118. doi: 10.1021/mp3006215
35. Luongo L, Petrelli R, Gatta L, et al. 5-Chloro-5-deoxy-(±)-ENBA, a potent and selective adenosine A(1) receptor agonist, alleviates neuropathic pain in mice through functional glial and microglial changes without affecting motor or cardiovascular functions. Molecules. 2012; 17(12): 13712-13726. doi: 10.3390/molecules171213712
36. Rossi F, Bellini G, Luongo L, et al. The 17-β-oestradiol inhibits osteoclast activity by increasing the cannabinoid CB2 receptor expression. Pharmacol Res. 2013; 68(1): 7-15. doi: 10.1016/j.phrs.2012.10.017
37. Luongo L, de Novellis V, Gatta L, et al. Role of metabotropic glutamate receptor 1 in the basolateral amygdala-driven prefrontal cortical deactivation in inflammatory pain in the rat. Neuropharmacology. 2013; 66: 317-329. doi: 10.1016/j.neuropharm.2012.05.047
38. Guida F, Luongo L, Aviello G, et al. Salvinorin A reduces mechanical allodynia and spinal neuronal hyperexcitability induced by peripheral formalin injection. Mol Pain. 2012; 8: 60. doi: 10.1186/1744-8069-8-60
39. Luongo L, Costa B, D-Agostino B, et al. Palvanil, a non-pungent capsaicin analogue, inhibits inflammatory and neuropathic pain with little effects on bronchopulmonary function and body temperature. Pharmacol Res. 2012; 66(3): 243-250. doi: 10.1016/j.phrs.2012.05.005
40. Palazzo E, Luongo L, Bellini G, et al. Changes in Cannabinoid Receptor Subtype 1 Activity and Interaction with Metabotropic Glutamate Subtype 5 Receptors in the Periaqueductal Gray-Rostral Ventromedial Medulla Pathway in a Rodent Neuropathic Pain Model. CNS Neurol Disord Drug Targets. 2012; 11(2): 148-161. doi: 10.2174/187152712800269731
41. Pasquini S, Mugnaini C, Ligresti A, et al. Design, synthesis, and pharmacological characterization of indol-3-ylacetamides, indol-3-yloxoacetamides, and indol-3-ylcarboxamides: potent and selective CB2 cannabinoid receptor inverse agonists. J Med Chem. 2012; 55(11): 5391-5402. doi: 10.1021/jm3003334
42. Rossi F, Bellini G, Tolone C, et al. The Cannabinoid Receptor type 2 Q63R variant increases the risk of celiac disease: Implication for a novel molecular biomarker and future therapeutic intervention. Pharmacol Res. 2012; 66(1): 88-94. doi: 10.1016/j.phrs.2012.03.011
43. Mugnaini C, Nocerino S, Pedani V, et al. Investigations on the 4-Quinolone-3-Carboxylic Acid Motif Part 5: Modulation of the Physicochemical Profile of a Set of Potent and Selective Cannabinoid-2 Receptor Ligands through a Bioisosteric Approach. ChemMedChem. 2012; 7(5): 920-934. doi: 10.1002/cmdc.201100573
44. de Novellis V, Luongo L, Guida F, et al. Effects of intra-ventrolateral periaqueductal grey palmitoylethanolamide on thermoceptive threshold and rostral ventromedial medulla cell activity. Eur J Pharmacol. 2012; 676(1-3): 41-50. doi: 10.1016/j.ejphar.2011.11.034
45. Lattanzi R, Sacerdote P, Franchi S, et al. Pharmacological activity of a Bv8 analogue modified in position 24. Br J Pharmacol. 2012; 166(3): 950-963. doi: 10.1111/j.1476-5381.2011.01797.x
46. Giordano C, Cristino L, Luongo L, et al. TRPV1-dependent and -independent alterations in the limbic cortex of neuropathic mice: impact on glial caspases and pain perception. Cerebral Cortex. 2012; 22(11): 2495-2518. doi: 10.1093/cercor/bhr328
47. D Siniscalco, C Giordano, U Galderisi, et al. Long lasting effects of human mesenchymal stem cell systemic administration on pain-like behaviours, cellular and biomolecular modifications in neuropathic mice. Front Integr Neurosci. 2011; 5: 79. doi: 10.3389/fnint.2011.00079
48. Palazzo E, Luongo L, de Novellis V, Rossi F, Marabese I, Maione S. Transient receptor potential vanilloid type 1 and pain development. Curr Opin Pharmacol. 2012; 12(1): 9-17. doi: 10.1016/j.coph.2011.10.022
49. Palazzo E, Guida F, Gatta L, et al. EP1 receptor within the ventrolateral periaqueductal grey controls thermonociception and rostral ventromedial medulla cell activity in healthy and neuropathic rat. Mol Pain. 2011; 7(1): 82. doi: 10.1186/1744-8069-7-82
50. Pasquini S, De Rosa M, Pedani V, et al. Investigations on the 4-quinolone-3-carboxylic acid motif. 4. Identification of new potent and selective ligands for the cannabinoid type 2 receptor with diverse substitution patterns and antihyperalgesic effects in mice. J Med Chem. 2011; 54(15): 5444-5453. doi: 10.1021/jm200476p
51. Aviello G, Borrelli F, Guida F, et al. Ultrapotent effects of salvinorin A, a hallucinogenic compound from Salvia divinorum, on LPS-stimulated murine macrophages and its anti-inflammatory action in vivo. J Mol Med. 2011; 89(9): 891-902. doi: 10.1007/s00109-011-0752-4
52. Giordano C, Siniscalco D, Melisi D, et al. The galactosylation of N(ω)-nitro-L-arginine enhances its anti-nocifensive or anti-allodynic effects by targeting glia in healthy and neuropathic mice. Eur J Pharmacol. 2011; 656(1-3): 52-62. doi: 10.1016/j.ejphar.2011.01.045
53. de Novellis V, Vita D, Gatta L, et al. The blockade of the transient receptor potential vanilloid type 1 and fatty acid amide hydrolase decreases symptoms and central sequelae in the medial prefrontal cortex of neuropathic rats. Mol Pain. 2011; 7: 7. doi: 10.1186/1744-8069-7-7
54. Francesca R, Giulia B, Livio L, et al. The endovanilloid/endocannabinoid system: a new potential target for osteoporosis therapy. Bone. 2011; 48(5): 997-1007. doi: 10.1016/j.bone.2011.01.001
55. Palazzo E, Marabese I, Soukupova M, et al. Metabotropic glutamate receptor subtype 8 in the amygdala modulates thermal threshold, neurotransmitter release and rostral ventromedial medulla cell activity in inflammatory pain. J Neurosci. 2011; 31(12): 4687-4697. doi: 10.1523/JNEUROSCI.2938-10.2011
56. De Filippis D, Luongo L, Cipriano M, et al. Palmitoylthanolamide reduces granuloma-induced hyperalgesia by modulation of mast cell activation in rats. Molecular Pain. 2011; 7: 3. doi: 10.1186/1744-8069-7-3
57. Palazzo E, Luongo L, de Novellis V, Berrino L, Rossi F, Maione S. Moving towards supraspinal TRPV1 receptors for chronic pain relief. Mol Pain. 2010; 6: 66. doi: 10.1186/1744-8069-6-66
58. Soukupova M, Palazzo E, Chiaro MD, et al. Effects of URB597, an inhibitor of fatty acid amide hydrolase (FAAH), on analgesic activity of paracetamol. Neuro Endocrinol Lett. 2010; 31(4): 507-511. Web site. http://europepmc.org/abstract/med/20802454. Accessed
59. Palazzo E, Luongo L, de Novellis V, Rossi F, Maione S. The Role of Cannabinoid Receptors in the Descending Modulation of Pain. Pharmaceuticals. 2010; 3(8): 2661-2673. doi: 10.3390/ph3082661
60. Siniscalco D, Giordano C, Galderisi U, et al. Human mesenchymal stem cells as novel neuropathic pain tool. J Stem Cells Regen Med. 2010; 6(2): 127.
61. Pasquini S, Ligresti A, Mugnaini C, et al. Investigations on the 4-quinolone-3-carboxylic acid motif. 3. Synthesis, structure-affinity relationships, and pharmacological characterization of 6-substituted 4-quinolone-3-carboxamides as highly selective cannabinoid-2 receptor ligands. J Med Chem. 2010; 53(16): 5915-5928. doi: 10.1021/jm100123x
62. Luongo L, Palazzo E, de Novellis V, Maione S. Role of endocannabinoid system in neuron-glia cross-talk. The Open Pain Journal. 2010; 3: 29-36.
63. Siniscalco D, Giordano C, Galderisi U, et al. Intra-brain microinjection of human mesenchymal stem cells decreases allodynia in neuropathic mice. Cell Mol Life Sci. 2010; 67(4): 655-669. doi: 10.1007/s00018-009-0202-4
64. Luongo L, Palazzo E, Tambaro S, et al. 1-(2,4-dichlorophenyl)-6-methyl-N-cyclohexylamine-1,4-dihydroindeno[1,2-c]pyrazole-3-carboxamide, a novel CB2 agonist, alleviates neuropathic pain through functional microglial changes in mice. Neurobiol Dis. 2010; 37(1): 177-185. doi: 10.1016/j.nbd.2009.09.021
65. Palazzo E, Guida F, Migliozzi A, et al. Intraperiaqueductal gray glycine and D-serine exert dual effects on rostral ventromedial medulla ON- and OFF-cell activity and thermoceptive threshold in the rat. J Neurophysiol. 2009; 102(6): 3169-3179. doi: 10.1152/jn.00124.2009
66. Maione S, Starowicz K, Cristino L, et al. Functional interaction between TRPV1 and μ-opioid receptors in descending antinociceptive pathway activates glutamate transmission and induces analgesia. J Neurophys. 2009; 101(5): 2411-2422. doi: 10.1152/jn.91225.2008
67. Franchetti P, Cappellacci L, Vita P, et al. N6-Cycloalkyl-, and N6-Bicycloalkyl-C5(C2)-modified Adenosine Derivatives as High-Affinity and Selective Agonists at Human A1 Adenosine Receptor with Antinociceptive Effects in Mice. J Med Chem. 2009; 52(8): 2393-2406. doi: 10.1021/jm801456g
68. Rossi F, Siniscalco D, Luongo L, et al. The endovanilloid/endocannabinoid system in human osteoclasts: possible involvement in bone formation and resorption. BONE. 2009; 44(3): 476-484. doi: 10.1016/j.bone.2008.10.056
69. Maione S, Morera E, Marabese I, et al. Antinociceptive effects of tetrazole inhibitors of endocannabinoid inactivation: cannabinoid and non-cannabinoid receptor-mediated mechanisms. Br J Pharmacol. 2008, 155: 775-782. doi: 10.1038/bjp.2008.308
70. de Novellis V, Palazzo E, Rossi F, et al. The analgesic effect of N-arachidonoyl-serotonin, a FAAH inhibitor and TRPV1 receptor antagonist, associated with changes in rostral ventromedial medulla and locus coeruleus cell activity in rats. Neuropharmacology. 2008, 55(7): 1105-1113. doi: 10.1016/j.neuropharm.2008.06.023
71. Luongo L, Sajic M, Grist J, Clark AK, Maione S, Malcangio M. Spinal changes associated with mechanical hypersensitivity in a model of Guillain-Barré syndrome. Neurosci Lett. 2008; 437(2): 98-102. doi: 10.1016/j.neulet.2008.04.019
72. Siniscalco D, Giordano C, Fuccio C, et al. Involvement of subtype 1 metabotropic glutamate receptors in apoptosis and caspase-7 over-expression in spinal cord of neuropathic rats. Pharmacol Res. 2008, 57(3): 223-233. doi: 10.1016/j.phrs.2008.01.007
73. Maione S, de Novellis V, Cappellacci L, et al. The antinociceptive effect of 2-chloro-2-C-methyl-N6-cyclopentyladenosine (2-Me-CCPA), a highly selective adenosine A1 receptor agonist, in the rat. Pain. 2007; 131(3): 281-292. doi: 10.1016/j.pain.2007.01.013
74. Siniscalco D, Fuccio C, Giordano C, et al. Role of reactive oxygen species and spinal cord apoptotic genes in the development of neuropathic pain. Pharmacol Res. 2007, 55(2): 158-166. doi: 10.1016/j.phrs.2006.11.009