Editorial Board


Heart Research - Open Journal

Patrizio Lancellotti


Professor of Cardiology
University of Liège
CHU Sart Tilman, Liège Belgium

BiographyResearch InterestScientific ActivitiesPublications
Present Position

Professor of Cardiology at University of Liège, CHU Sart Tilman, Liège Belgium
Director of the Cardiologist Intensive Unit at University Hospital of Liège
Head of the Echocardiography Laboratory and the Heart Valve Clinic
Director of the GIGA Cardiovascular Sciences Research Programme at the University of Liège, Belgium


Training and Education

University of Liège, Doctor of Medicine. 1995
Internship License at University Hospital of Liège 1998
Cardiologist License at University Hospital of Liège 2000
Licensed in Intensive Care Unit at University Hospital of Liège 2002
Training in heart transplantation 2001


Post Graduate Degrees

Thèse de Doctorat, PhD Thesis at University Hospital of Liège 2002
Thèsed’ Agrégation del’ Enseignement Supérieur 2005
Clinical Professor at University Hospital of Liège 2007
Professor of Cardiovascular imaging at University of Liège:2010

Major Research Interest

Project leader

• PV-COAT study for the prevention of prosthetic valve thrombosis funded by an ERC (European Research Commission, 2015--‐2019) grant
• EACVI/HFA EURObservational Research Programme committee (EORP) on Cardiac-Oncology Toxicity in Breast Cancer(ESC-COT)
• New Insights into the Development and Progression of Aortic valve Stenosis (TheNID-PAS Study):FRS-FNRS Funded
• Progression and Outcome of secondary mitral regurgitation (POMAR Registry): 3D Echocardiography
• Radiation-induced heart disease (AVRI study): Animal study
• Normal Reference Ranges for Echocardiography: Rationale, Study design and Methodology (NORRE Study)
• HeArt ValvE Clinic International Database (HAVEC)
• European multicenter validation study of the accuracy of E/e’ ratio in estimating invasive left ventricular • Filling pressure (EURO-FILLING STUDY)

Fellowships/Honours

• Fellow of the European Association of cardiology (FESC) 2010
• Fellow of the American College of Cardiology(FACC) 2012
• Honorary member of the British Society of Echocardiography 2014
• Honorary citizen of the city of Liege, Belgium 2014
• Honorary Member of the Hungarian Society of Cardiology 2014
• Invited Professor for the 8th Annual Tajik/Seward lectureship, Mayo Clini 2013
• InBev--‐Baillet Latour Award for clinical research in the field of cardiovascular disease, 2008
• Lambertine Lacroix Award in the field of cardiovascular disease, 2008.
• Award from the «Fondation Jaumain», 2006
• Best poster presented of the French Society of Cardiology, 2005
• Best poster presented of the XXVII Congress of the European Society of Cardiology, 2005
• Jacqueline Bernheim Award of the« foundation pour la chirurgie cardiaque», 2004
• Young Investigator Award of the Belgian Society of Cardiology, 2001

Some Major Publications

More than 335 peer-reviewed papers. Several book chapters
1. Lancellotti P, et al. Therapeutic decision-making for patients with fluctuating mitral regurgitation. Nat Rev Cardiol. 2015.
2. Lancellotti P, et al. ESC Working Group on Valvular Heart Disease Position Paper–heart valve clinics: organization, structure, and experiences. Eur Heart J. 2013
3. Lancellotti P, et al. Determinants and prognostic significance of exercise pulmonary hypertension in asymptomatic severe aortic stenosis. Circulation 2012
4. Lancellotti P, et al. Clinical outcome in asymptomatic severe aortic stenosis: insights from the new 5. Proposed aortic stenosis grading classification. J Am Coll Cardiol. 2012
6. LA Piérard, P. Lancellotti. The role of ischemic mitral regurgitation in the pathogenesis of acute pulmonary edema. N Engl J Med 2004
7. Lancellotti P, et al. Detection and clinical usefulness of a biphasic response during exercise echocardiography early after myocardial infarction. J Am Coll Cardiol 2003
8. Lancellotti P, et al. Prognostic importance of exercise-induced changes in mitral regurgitation in 9. patients with chronic ischemic left ventricular dysfunction. Circulation 2003

Gaetano Santulli, MD, PhD

Columbia University Medical Center
1150 St. Nicholas Ave - Suite 513
New York, NY 10032, USA

BiographyResearch InterestScientific ActivitiesPublications

Dr. Santulli is a principal investigator currently working at Columbia University. A physician-scientist, he received his MD and PhD at the University of Naples “Federico II”. Dr. Santulli completed his postdoctoral training at Columbia University Medical Center in New York City, supported by an American Heart Association (AHA) fellowship and a Scientist Development Grant. Dr. Santulli’s expertise comprises both clinical he is a cardiologist and basic research topics, including hypertension, diabetes, heart failure, arrhythmias, vascular disease, micro RNA, and mitochondrial pathophysiology. He serves on the editorial boards of numerous medical journals and he is Editor-in-Chief of the Journal of Cardiovascular Disease (JCvD). He authored more than 100 peer-reviewed publications and edited several medical books. He recently published ‘Adrenal Glands: From pathophysiology to clinical evidence’ and ‘micro RNA: From Molecular Biology to Clinical Practice’.


EDUCATIONAL QUALIFICATIONS


• (2005) MD, Degree in Medicine and Surgery, summa cum laude at the University of Naples “Federico II”, Italy.
• (2005-2005) Fellow: University of Lisbon, Portugal - Department of Cardiology. .
• (2005-2010) Clinical Fellow; Department of Medicine and Cardiovascular Sciences, “Federico II” University. .
• (2007-2007) Visiting Scientist: Medical College - Thomas Jefferson University –– Philadelphia (PA), U.S.A. .
• (2010) Residency/Fellowship in Cardiology, summa cum laude at the “Federico II” University. .
• ( 2013) PhD in Translational Medicine, summa cum laude - “Federico II” University. .
• ( 2011)-(Present) Research Scholar, Columbia University Medical Center, New York (NY), U.S.A. .

His research interest include: Hypertension, aging, diabetes, angiogenesis, myocardial infarction, heart failure, atrial fibrillation, cardiac hypertrophy, vascular disease, calcium handling, micro RNA, cardiac resynchronization therapy, adrenergic receptors, vascular reactivity, Angioplasty, restenosis, interventional cardiology, thrombosis, excitation-contraction coupling, animal models, ischemia-reperfusion, arrhythmias, metabolic syndrome, endothelium, endothelial function, panic disorder, angiopoietin-like proteins, adrenal gland, calcium imaging, m TOR, drug eluting stents, pathophysiology, chronic obstructive pulmonary disease, insulin release, mitochondria, cardiac energetics, integrins, polymorphisms,insulin resistance.

• (2008) Winner - Young Investigator Award, Italian Society of Hypertension.
• (2010) European Society of Cardiology (ESC) Award - Council on Cardiovascular Science Award.
• (2011) Winner - Italian Ministry of Welfare Research Award
• (2011) Winner - Young Investigator Award, Veronesi Foundation for Cardiovascular Research.
• (2013) Winner - American Heart Association (AHA) Postdoctoral Fellowship (High Score: 1.17).
• (2013) Winner - “Harvey” Award for Research in Cardiology (Italian Society of Cardiology)
• (2014) Finalist - Presidential Award for Precision Medicine (ENDO Meeting).
• (2015) Winner - AHA Scientist Development Grant (High Score: 1.12 – First Submission)
• (2015) Winner - NIH K99/R00 (High Score: 13 – Funded at First Submission).
• (2016) Finalist - (ISHR) World meeting Cardiology – Young Investigator Award.
• (2016) Included among Top Italian Scientists Worldwide – V.I.A. Academy (highly cited).
• (2016) Winner – Sentinel of Science (Worldwide top overall contributor to peer review in science and research) – Publons.

85. Gambardella J, Santulli G. Integrating diet and inflammation to calculate cardiovascular risk. Atherosclerosis. 2016, in press. doi: 10.1016/j.atherosclerosis.2016.08.041
84. Santulli G. Dietary components and metabolic dysfunction: translating preclinical studies into clinical Practice. Nutrients. 2016, in press. doi: 10.3390/nu8100632
81. Gautheret D, Taube J, Mani SA, Santulli G, Cuerda-Gil D, Slotkin RK. Microbiome and microrna mediate the communication between gut and vasculature. Non-Coding RNA. 2016 ; in press
80. Santulli G, Yuan Q, Yang J, et al. Maintenance of normal blood pressure is dependent on ip3r1-mediated regulation of enos. Proc Natl Acad Sci U S A.2016, in press. doi: 10.1073/pnas.1608859113
79. Ciccarelli M, Finelli R, Santulli G, Rivera N. The possible role of chromosome x variability in hypertensive familiarity. Journal of Human Hypertension (Nature Publishing Group). 2016 ; in press. doi: 10.1038/jhh.2016.9
78. Santulli G, Iaccarino G. Adrenergic signaling in heart failure and cardiovascular aging. Maturitas. 2016 ; in press. doi: 10.1016/j.maturitas.2016.03.022
77. Matecki S, Dridi H, Jung B, et al. Leaky ryanodine receptors contribute to diaphragmatic weakness during mechanical Ventilation. Proc Natl Acad Sci U S A.2016, 113(32): 9069-9074. doi: 10.1073/pnas.1609707113
76. Santulli G. Micrornas distinctively regulate vascular smooth muscle and endothelial cells: functional Implications in angiogenesis, atherosclerosis, and in-stent restenosis. Adv Exp Med Biol. 2015 ; 887: 53-77. doi: 10.1007/978-3-319-22380-3_13
75. Berindan-Neagoe I, Calin GA, Francastel C, Hubé F, Santulli G. Micromanipulating the behavior via microrna: New lessons from drosophila. Non-Coding RNA. 2015 ; 1: 285-288
74. Santulli G, Xie W. Mitochondrial calcium overload is a key determinant in heart failure. Proc Natl Acad Sci U S A.2015 ; 112: 11389-11394. doi: 10.1073/pnas.1513047112
73. Santulli G, Borras C, Bousquet J, et al. Models for preclinical studies in aging-related disorders: one is not for all. Transl Med @ UniSa. 2015 ; in press
72. Novák J , Olejníčková V , Tkáčová N , Santulli G. Mechanistic role of micrornas in coupling lipid metabolism and atherosclerosis. 2015 ; 887: 79-100. doi: 10.1007/978-3-319-22380-3_13
71. Santulli G. An interview with gaetano santulli. European Medical Journal (EMJ) Cardiology. 2015 ; 3.2: 35-37
70. Santulli G. Micrornas and endothelial (dys) function. J Cell Physiol. 2015 ; 231: 1638–1644
69. Santulli G. A leaky endoplasmic reticulum calcium channel impairs insulin secretion. J Clin Invest. 2015
68. Santulli G, Marks AR. Essential roles of intracellular calcium release channels in muscle, brain, and metabolism. Current Molecular Pharmacology. 2015 ; 8(2): 206-222
83. Santulli G. Childhood obesity and education. Lancet Diabetes Endocrinol. 2016 ; in press. doi: 10.1016/S2213-8587(15)00517-3
82. Sardu C, Santamaria M, Rizzo MR, et al. Telemonitoring in heart failure patients treated by cardiac resynchronisation therapy with Defibrillator (crt-d): The telecart study. Int J Clinical Practice. 2016 ; 70: 569-76. doi: 10.1111/ijcp.12823
67. Santulli G. Exploiting microrna specificity and selectivity: paving a sustainable path towards precision Medicine. Adv Exp Med Biol. 2015 ; 888: 1-3. doi: 10.1007/978-3-319-22671-2_1.
66. Cipolletta E, Rusciano MR, Maione AS, Santulli G, Sorriento D. Targeting the camkii/erk interaction in the heart prevents cardiac hypertrophy. PLoS One. 2015 ; 10(6): e0130477. doi:
65. Sorriento D, Santulli G, Franco A, Cipolletta E, Napolitano L. Integrating grk2 and nfkappab in the pathophysiology of cardiac hypertrophy. J Card Transl Res. 2015 ; 8: 493-502. doi: 10.1007/s12265-015-9646-0
64. Xie W, Santulli G, Reiken SR, Yuan Q, Osborne BW. Mitochondrial oxidative stress promotes atrial fibrillation. Nature Scientific Reports. 2015 ; 5: 11427. doi: 10.1038/srep11427
63. Francastel C, Hubé F, Mani S, Santulli G, Taube JH. Mitochondrial calcium overload and oxidative stress in cardiomyocytes are linked by microrna. Non-Coding RNA. 2015 ; 1: 167-169
62. Santulli G, Pagano G, Sardu C, et al. Calcium release channel ryr2 regulates insulin release and glucose homeostasis. Journal of Clinical Investigation. 2015 ; 125(5): 1968-1978
61. Santulli G. A fleeting glimpse inside microrna, epigenetics, and micropeptidomics. Adv Exp Med Biol. 2015 ; 887: 1-14. doi: 10.1007/978-3-319-22380-3_1
60. Wronska A, Kurkowska-Jastrzebska I, Santulli G. Application of micrornas in diagnosis and treatment of cardiovascular disease. Acta Physiol. 2015 ; 213(1): 60-83. doi: 10.1111/apha.12416
59. Santulli G. β-Blockers in diabetic patients with heart failure. JAMA Intern Med. 2015 ; 175(4): 657. doi: 10.1136/openhrt-2014-000230
58. Santulli G. Effects of low-carbohydrate and low-fat diets. Ann Intern Med. 2015 ; 162(5): 392. doi: 10.7326/L15-5192-5.
57. Yuan Q, Chen Z, Santulli G, Gu L, Yang ZG, Yuan ZQ. Functional role of calstabin2 in age-related cardiac alterations. Nature (Sci Rep.). 2014 ; 4: 7425. doi: 10.1038/srep07425
56. Umanskaya A, Santulli G, Xie W, Reiken S, Marks AR. Genetically enhancing mitochondrial antioxidant activity improves muscle function in aging. Proc Natl Acad Sci U S A.2014 ; 111: 15250-5. doi: 10.1073/pnas.1412754111
55. Santulli G. Microrna-directed gene delivery selectively targets vsmcs to prevent restenosis. JCI Impact. 2014
54. Ferracin M, Gautheret D, Hubé F, et al. Diabetes asking for trouble: Terminating microrna biogenesis in ear stress. Non-Coding RNA 2015 ; 1: 87-93.
53. Ferracin M, Gautheret D, Hubé F, et al. Myoregulin is a novel modulator of calcium handling and excitation-contraction coupling: Hunting for easter eggs in the concealed microproteome. Non-Coding RNA 2015 ; 1: 87-93
52. Nguyen FT, Patel C, Santulli G. An interview with gaetano santulli. Journal of Clinical Investigation. 2014. doi: 10.1172/JCI76069.
51. Santulli G, Wronska A, Uryu K, et al. A selective microrna-based strategy inhibits restenosis while preserving endothelial function. Journal of Clinical Investigation. 2014 ; 124: 4102-4114
50. Sardu C, Marfella R, Santulli G, Paolisso G. Functional role of miRNA in cardiac resynchronization therapy. Pharmacogenomics. 2014 ; 15: 1159-1168. doi: 10.2217/pgs.14.76
49. Soares-Filho GLF, Arias-Carrión O, Santulli G, Silva AC, Machado S. Chest pain, panic disorder and coronary artery disease: A systematic review. CNS Neurol Disord Drug Targets. 2014 ; 13: 992-1001
48. Ciccarelli M, Rusciano M, Sorriento D, Basilicata MF, Santulli G, Campiglia P. Camkii protects mkp-1 from proteasome degradation in endothelial cells. Cell Signal. 2014 ; 26: 2167-74. doi: 10.1016/j.cellsig.2014.06.009
47. Sorriento D, Ciccarelli M, Santulli G, Illario M, Trimarco B, Iaccarino G. Trafficking GRK2: Cellular and metabolic consequences of GRK2 subcellular localization. Transl Med @ UniSa. 2014 ; 10: 3-7
46. Sardu C, Marfella R, Santulli G. Impact of diabetes mellitus on the clinical response to cardiac resynchronization therapy in elderly people. J Card Transl Res. 2014 ; 7: 362-368. doi: 10.1007/s12265-014-9545-9
45. Santulli G, Iaccarino G, Luca ND, Trimarco B, Condorelli G. Atrial fibrillation and micrornas. Frontiers in Physiology. 2014 ; 24 ; 5: 15. doi: 10.3389/fphys.2014.00015
44. Sardu C, Carreras G, Katsanos S, et al. Metabolic syndrome is associated with a poor outcome in patients affected by outflow tract Premature ventricular contractions treated by catheter ablation. BMC Cardiovasc Disord. 2014 ; 14: 176. doi: 10.1186/1471-2261-14-176.
43. Santulli G. Adrenal signaling in heart failure: something more than a distant ship’s smoke on the horizon. Hypertension. 2014 ; 63: 215-216. doi: 10.1161/HYPERTENSIONAHA.113.02382
42. Santulli G. Angiopoietin-like proteins: a comprehensive look. Frontiers in Endocrinology. 2014 ; 2: 5: 4. doi: 10.3389/fendo.2014.00004
41. Santulli G, Jain HT. Tailoring mtor-based therapy: Molecular evidence and clinical challenges. Pharmacogenomics. 2013 ; 14: 1517-1526. doi: 10.2217/pgs.13.143
40. Gastão LF. Soares-Filho, Machado S, et al. Myocardial perfusion imaging study of CO2-induced panic attack. Am J Card. 2013 ; 113: 384-388. doi: 10.1016/j.amjcard.2013.09.035
39. Xie W, Santulli G, Guo X, Gao M. Imaging atrial arrhythmic intracellular calcium in intact heart. J Mol Cell Cardiol. 2013 ; 64: 120-3. doi: 10.1016/j.yjmcc.2013.09.003
38. Santulli G, Ciccarelli M, Trimarco M, Iaccarino G. Physical activity ameliorates cardiovascular health in elderly subjects: The functional role of the β adrenergic system. Frontiers in Physiology. 2013 ; 4: 209. doi: 10.3389/fphys.2013.00209
37. Santulli G, Trimarco B, Iaccarino G. G-protein-coupled receptor kinase 2 and hypertension: molecular insights and pathophysiological mechanisms. High Blood Press & Cardiovasc Prev. 2013 ; 20: 5-12. doi:
36. Santulli G, Iaccarino G. The essential role of beta 2 adrenergic receptor in glucose homeostasis. PLoS One. 2013 ; doi: 10.1093/cvr/cvp252
35. Santulli G, Iaccarino G. Pinpointing beta adrenergic receptor in ageing Pathophysiology: victim or executioner? Evidence from crime scenes. Immun Ageing. 2013 ; 15(10): 10. doi: 10.1186/1742-4933-10-10
34. Santulli G. Epidemiology of cardiovascular disease in the 21st century: updated numbers and updated facts. Journal of Cardiovascular Disease (JCvD). 2013 ; 1: 1-2
33. Matarese A, Santulli G. Angiogenesis in chronic obstructive pulmonary disease: A Translational Appraisal. Nature Prec. 2012
32. Santulli G, Ascia S D’, Ascia C D’. Development of atrial fibrillation in recipients of cardiac resynchronization therapy: the role of atrial reverse remodelling. Can J Cardiol. 2012 ; 28: 245.e17-245.e18. doi: 10.1016/j.ahj.2008.04.013
31. Santulli G, Ascia S D’, Ascia C D’. The impact of left ventricular size on response to cardiac resynchronization therapy. Am Heart J. 2012 ; 163: e11. doi: 10.1016/j.ahj.2011.07.008
30. Santulli G, Cipolletta E, Sorriento D, Giudice C D, Anastasio A, Monaco S. Camk four gene deletion induces hypertension. JAHA, Journal of the American Heart Association. 2012 ; 1: e001081. doi: 10.1161/JAHA.112.001081
29. Santulli G. Coronary heart disease risk factors and mortality. Journal of the American Medical Association - JAMA. 2012 ; 307: 1137. doi: 10.1001/jama.2012.323
28. Sorriento D, Santulli G, Giudice C D, Anastasio A, Trimarco B, Iaccarino G. Endothelial cells are able to synthesize and relea catecholamines both in vitro and in vivo. Hypertension. 2012 ; 60: 129-136. doi: 10.1161/HYPERTENSIONAHA.111.189605
27. Santulli G, Chiariello M, Ascia C D’, Ascia S D’. Role of cardiac resynchronization therapy in the development of new-onset atrial fibrillation: A single-center prospective study. Nature Prec. 2012 ; doi: 10.1038/npre.2012.7137.1
26. Santulli G .Thrombolysis outcomes in acute ischemic stroke patients with prior stroke and diabetes mellitus. Neurology. 2012 ; 78: 840. doi: 10.1212/WNL.0b013e318238ee42
25. Santulli G, Ascia C D’. Atrial remodelling in echocardiographic super-responders to cardiac resynchronization therapy. Heart. 2012 ; 98: 517
24. Santulli G, Lombardi A, Sorriento D, Anastasio A, Giudice C D, Formisano P, et al. Age-related impairment in insulin release: The essential role of βeta2 adrenergic receptor. Diabetes. 2012 ; 61: 692-701
23. Santulli G, Ascia S D’, Marino V, Ascia C D’. A trial function in patients undergoing crt. JACC Imaging. 2012 ; 5: 124-125
22. Fusco A, Santulli G, Sorriento D, et al. Mitochondrial localization unveils a novel role for grk2 in organelle biogenesis. Cell Signal. 2012 ; 24: 468-475. doi: 10.1016/j.cellsig.2011.09.026
21. Matarese A, Santulli G. Angiogenesis in chronic obstructive pulmonary disease. Transl Med @ UniSa. 2012 ; 3: 49–56. doi: 10.12775/v10251-012-0050-6
20. Santulli G, Campanile A, Spinelli L, di Panzillo E A, Ciccarelli M. G Protein-Coupled receptor kinase 2 in patients with acute myocardial infarction. Am J Cardiol. 2011 ; 107: 1125-1130. doi: 10.1016/j.amjcard.2010.12.006
19. Santulli G, Basilicata M, Simone M D, Giudice C D, Anastasio A, Sorriento D. Evaluation of the anti-angiogenic properties of the new selective alphavbeta3 integrinantagonist rgdechihcit. J Transl Med. 2011 ; 9: 7. doi: 10.1186/1479-5876-9-7.
18. Ascia . SL.D’, Ascia C D’, Marino V, Chiariello M, Santulli G. Cardiac resynchronization therapy response predicts occurrence of atrial fibrillation in nonischemic dilated cardiomyopathy. Int J Clinical Practice. 2011 ; 69: 1149-1155. doi: 10.1111/j.1742-1241.2011.02732.x
17. Perino A, Ghigo A, Ferrero E, et al. Integrating cardiac PIP3 and CAMP signaling through a pka anchoring function of p110γ. Molecular Cell. 2011 ; 42: 84-95. doi: 10.1016/j.molcel.2011.01.030
16. Ciccarelli M, Sorriento D, Santulli G, et al. Impaired Neoangiogenesis in β2-Adrenoceptor gene-deficient mice: Restoration by Intravascular human β2 -Adrenoceptor gene transfer and role of NFκB and CREB Transcription factors. British J Pharmacology. 2011 ; 162: 712-721. doi: 10.1111/j.1476-5381.2010.01078.x
15. Santulli G, Sorriento D, Fusco A, Anastasio A. Intracardiac injection of adGRK5-NT reduces left ventricular hypertrophy by inhibiting NF-kB-Dependent hypertrophic gene expression. Hypertension. 2010 ; 56: 696-704. doi: 10.1161/HYPERTENSIONAHA.110.155960
14. Galasso G, Santulli G, Piscione F, De Rosa R, Piccolo R, Cassese S. The GPIIIA PLA2 Polymorphism is associated with an increased risk of Cardiovascular adverse Events. BMC Cardiovascular Disorders. 2010 ; 10: 41. doi: 10.1186/1471-2261-10-41
13. Ascia SL.D’, Santulli G, Liguori V, Marino V, Chiariello M. Advanced algorithms can lead to electrocardiographic misinterpretations. International Journal of Cardiology. 2010 ; 141: e34-e36. doi: 10.1016/j.ijcard.2008.11.144
12. Santulli G, Ciccarelli M, Palumbo G, Campanile A, Galasso G, Ziaco B-In vivo properties of the proangiogenic peptide QK. J Transl Med. 2009 ; 7: 41. doi: 10.1186/1479-5876-7-41
11. Sorriento D, Campanile A, Santulli G, Leggiero E, Pastore L. A new synthetic protein, TAT-RH, inhibits tumor growth through the regulation of NFkB activity. Molecular Cancer. 2009 ; 8: 97
10. Cipolletta E, Campanile A, Santulli G, Sanzari E, Leosco D, Campiglia P. The G Protein Receptor Kinase 2 Plays An Essential Role In Beta Adrenergic Receptor Induced Insulin Resistance. Cardiovasc Res. 2009 ; 84: 407-415. doi: 10.1093/cvr/cvp252
9. Oriente F, Iovino S, Cassese A, et al. Overproduction of phosphoprotein enriched in diabetes (PED) induces mesangial expansion and upregulates protein kinase c-beta activity and TGF-beta1 expression. Diabetologia. 2009 ; 52: 2642-2652. doi: 10.1007/s00125-009-1528-z
8. Sorriento D, Ciccarelli M, Santulli G, et al. The g-protein-coupled receptor kinase 5 inhibits NFkB Transcriptional activity by inducing Nuclear accumulation of IκBα. Proc Natl Acad Sci U S A.2008 ; 195: 17818-17823. doi: 10.1073/pnas.0804446105
7. Izzo R, Cipolletta E, Ciccarelli M, Campanile A, Santulli G, Palumbo G. Enhanced GRK2 Expression and Desensitization of βAR Vasodilatation in Hypertensive Patients. Clinical and Translational Science. 2008 ; 1: 215-220. doi: 10.1111/j.1752-8062.2008.00050.x
6. Ciccarelli M, Santulli G, Campanile A, Galasso G, Cervèro P. Endothelial alpha-1 adrenergic receptors regulate neo-angiogenesis. British J Pharmacology. 2008 ; 153: 936-946. doi: 10.1038/sj.bjp.0707637
5. Lanni F, Santulli G, Izzo R, et al. The Pl(A1/A2) polymorphism of glycoprotein IIIa and cerebrovascular events in hypertension: increased risk of ischemic stroke in high-risk patients. J Hypertension. 2007 ; 25: 551-556. doi: 10.1097/HJH.0b013e328013cd67
4. Ciccarelli M, Cipolletta E, Santulli G, Campanile A, Pumiglia K, Cervèro P. Endothelial β2 adrenergic signaling to AKT: Role of Gi and SRC. Cell Signal. 2007 ; 19: 1949-1955. doi: 10.1016/j.cellsig.2007.05.007
3. Iaccarino G, Campanile A, Santulli G, Zuppieri F, and Koch JW. G Protein-Coupled Receptor Kinases and Hypertension: A Review of Disease Mechanisms. High Blood Pressure & Cardiovascular Prevention. 2006 ; 13(4): 151-158. doi: 10.2165/00151642-200613040-
2.Iaccarino G, Ciccarelli M, Sorriento D, et al. Ischemic Neoangiogenesis Enhanced by β2-Adrenergic Receptor Overexpression: A novel role for the endothelial adrenergic system. Circulation Research. 2005 ; 97: 1182-1189. doi: 10.1161/01.RES.0000191541.06788.bb
1. Iaccarino G, Ciccarelli M, Sorriento D, et al. AKT Participates in Endothelial Dysfunction in Hypertension. Circulation. 2004 ; 109: 2587-2593. doi: 10.1161/01.CIR.0000129768.35536.FA

Tommaso Poggioli, PhD

Department of Medicine
Harvard Medical School
Brigham and Womens Hospital
Boston, MA, USA

BiographyResearch InterestScientific ActivitiesPublications
EDUCATION


• (Oct 2010-March 2014) PhD in Cardiovascular Science (Fellowship from the British Hearth Foundation Centre of Excellence), Imperial College London, London, United Kingdom
• (Oct 2009-Oct 2010) M Res in Biomedical Sciences (with distinction), National Heart and Lung Institute, Imperial College London, London, United Kingdom
• (Feb 2006-May 2008) MS in Molecular Biology and Genetics (110/110 cum laude), Biology Faculty of Life Sciences, Department of Biology, University of Roma Tre, Italy
• (Sept 2003-Sept 2004) Erasmus international exchange programme in biology, Complutense University of Madrid, Madrid, Spain
• (Sept 2001-Feb 2006) BS in Biology Faculty of Life Sciences, Department of Biology, University of Roma Tre, Italy

His research interest include: Development of biotechnologies to discover and Design new approaches to cardiovascular and Metabolic diseases. He is particularly interested in Cardiac hypertrophy, In vivo cardiac pathological models, Aging and Diabetes.

MEMBERSHIPS


• (2013-Present) American Heart Association
• (2014) Harvard Innovation and Commercialization competition winner, Harvard University, Boston, MA
• (2011) Massachusetts Institute of Technology (MIT)/Imperial College London Summer School scholarship
• (2009-2014) MRes/PhD studentship, British Heart Foundation Centre of Research Excellence, Imperial College London
• (2008-2009) Post MS fellowship, FILAS, Rome, Italy
• (2008) EEMS Young Scientist Travel Award 2008 (YSTA) Cavtat, Croatia
• (2003-2004) Erasmus Exchange program scholarship, Complutense University of Madrid


SCHOLARSHIPS AND AWARDS


• Harvard Innovation and Commercialization competition winner-Harvard University (2014)
• 4 year MRes/PhD studentship from the British Heart Foundation Centre of Research Excellence at Imperial College London (2009-2013)
• Massachusetts Institute of Technology (MIT)-Imperial College London Summer School scholarship (2011)
• Post Lauream fellowship “Completion courses Scientific”, FILAS (2008)
• EEMS Young Scientist Travel Award 2008 (YSTA). Cavtat, Croatia (2008)
• Erasmus Exchange programme scholarship. Complutense University of Madrid (2003-2004)

1. Poggioli T, Sarathchandra P, Rosenthal N, Santini MP. Intramyocardial cell delivery: observations in murine heart. J Vis Exp. 2014; (83): e51064. doi: 10.3791/51064
2. Zarrinpashneh E, Poggioli T,SarathchandraS, et al. Ablationof SGK1 impairs endothelial cell migration and tube formation leading to decreased neo-angiogenesis following myocardial infarction. PLoS One. 2013; 8(11): e80268. doi: 10.1371/journal.pone.0080268
3. Lexow L, Poggioli T, Sarathchandra P, Santini MP, Rosenthal N. Cardiac fibrosis in tamoxifen treated αMHC-MerCreMer animals. Dis Model Mech. 2013; 6(6): 1470-1476. doi: 10.1242/dmm.010470
4. Lexow J, Poggioli T, Rosenthal N, Santini MP. Combinatorial Therapies for Cardiac Regeneration. Recent Patents on Regenerative Medicine. 2013; 3(1). doi: 10.2174/2210296511303010034
5. Santini MP, Lexow J, Borsellino G, et al. IGF-1Ea induces vessel formation after injury and mediates bone marrow and heart cross-talk through the expression of specific cytokines. Biochem Biophys Res Commun. 2011; 410(2): 201-207. doi: 10.1016/j.bbrc.2011.05.081
6. Poggioli T, Sterpone S, Palma S, Cozzi R, Testa A. G0 and G2 Chromosomal Assays in the Evaluation of Radiosensitivity in a Cohort of Italian Breast Cancer Patients. J Radiat Res. 2010; 51(5): 615-619. doi: 10.1269/jrr.10052
7. Cornetta T, Patrono C, Terrenato I, et al. Epidemiological, Clinical, and Molecular Study of a Cohort of Italian Parkinson Disease Patients: Association with Glutathione-S-Transferase and DNA Repair Gene Polymorphisms. Cell Mol Neurobiol. 2013; 33(5): 673-680. doi: 10.1007/s10571-013-9933-8

Mahazarin Ginwalla, MD, MS

Assistant Professor of Medicine
Medical Director of Mechanical Circulatory Support
Division of Cardiovascular Medicine
University Hospitals of Cleveland
Case Western Reserve School of Medicine
11100 Euclid Avenue, Cleveland, OH 44106, USA

BiographyResearch InterestScientific ActivitiesPublications

Dr. Ginwalla is currently an Assistant Professor and Medical Director of Mechanical Circulatory Support at the University Hospitals Case Medical Center, Cleveland, Ohio. Dr. Ginwalla obtained her M.B.B.S. degree from Lokmanya Tilak Medical College in Mumbai, India. She completed her Masters in Medical Microbiology and Immunology at the University of Wisconsin-Madison. She subsequently completed her Internal Medicine residency at the Medical College of Wisconsin in Milwaukee, and Cardiovascular diseases fellowship at Case Western Reserve University/Metrohealth Medical Center. Following this, she completed her Advanced Heart Failure and Cardiac Transplantation fellowship at Stanford University Medical Center in Palo Alto, California.

Her research interests include: The field of advanced heart failure, mechanical circulatory support, and cardiac transplantation. She is currently involved in research on left ventricular assist device thrombosis and myocardial recovery post left ventricular assist device implantation. Her other varied research interests include sickle cell cardiomyopathy, reducing rehospitalizations in heart failure patients, and the management of pulmonary hypertension prior to cardiac transplantation.

Certifications

• American Board of Internal Medicine (ABIM): Advanced Heart Failure and Transplant Cardiology
• American Board of Internal Medicine (ABIM): Cardiovascular Disease
• American Board of Internal Medicine (ABIM): Internal Medicine
• Advanced Life Support
• Basic Life Support


Memberships

• American College of Cardiology
• American Heart Association
• Heart Failure Society of America
• International Society of Heart and Lung Transplantation
• Indian Medical Association
• Member of Skilled Nursing Facility (SNF) Connect Clinical Endpoints Committee (CEC)

1. Al-Kindi SG, El-Amm C, Ginwalla M, Hoit BD, Park SJ, Oliveira GH. Heart transplant outcomes in patients with left ventricular non-compaction cardiomyopathy. J Heart Lung Transplant. 2014; S1053-2498(14)01438-7. doi: 10.1016/j.healun.2014.11.005
2. Ginwalla M, Pando M, Khush K. Pregnancy-related human leukocyte antigen sensitization leading to cardiac allograft vasculopathy and graft failure in a heart transplant recipient. Transplantatation Proceedings. 2013; 45(2): 800-802. doi: 10.1016/j.transproceed.2012.10.038.
3. Lang J, Kaikobad M, Wallace M, et al. Pilot trial of interleukin-2 and zoledronic acid to augment γδ T cells as treatment for patients with refractory renal cell carcinoma. Cancer Immunol Immunotherapy. 2011; 60(10): 1447-1460. doi: 10.1007/s00262-011-1049-8
4. Ginwalla M, Pillai D, Gandhi S. Use of Intra-aortic balloon counter pulsation during emergent cesarean section in a pregnant patient with myocardial infarction. Journal of Invasive Cardiology. 2010 ; 22(6): E104-E106.
5. Ginwalla M, Battula S, Dunn J, Lewis W. Termination of Electrocution-Induced Ventricular Fibrillation by an Implantable Cardioverter-Defibrillator. Pacing and Clinical Electrophysiology. 2009; 33(4): 510-512. doi: 10.1111/j.1540-8159.2009.02607.x
6. Ginwalla M, Biblo L, Paydak H. Torsades de Pointes following intravenous haloperidol administration in a patient with complete heart block. Wisconsin Medical Journal. 2009; 108(1): 48-50.
7. Kaikobad M, Cheng YC, Choi H, Teves D. Primary mediastinal embryonal carcinoma masquerading as chronic pancreatitis. Wisconsin Medical Journal. 2007; 106(4): 225-228.
8. Kaikobad M, Teves D. A Cancer with a Twist. Journal of General Internal Medicine. 2006; 21(s4).
9. Malkovsky M, Wallace M, McNeel DG, et al. Towards therapeutic stimulations of γδ T cells. Haematologica Reports. 2006; 2(3): 29-31.

Yunusemre Ozkanlar, DVM, PhD

Professor of Veterinary Internal Medicine
Director of the Veterinary Hospital
Ataturk University
Erzurum, 25240, Turkey

BiographyResearch InterestScientific ActivitiesPublications

Dr. Ozkanlar is currently a Professor of Veterinary Internal Medicine and the Director of Veterinary Hospital in Ataturk University Erzurum, Turkey. Dr. Ozkanlar obtained his DVM and PhD degree from Ankara University, Turkey. He has studied for his post-doctoral researches at the Ohio State University USA. He has attended a training program for tissue Doppler and Strain analysis at the Emory Hospital in Atlanta, USA. He has conducted experimental researches at the Cardiology Lab with the cardiology researchers in College of Medicine, College of Pharmacy and Veterinary Cardiology in the Ohio State University USA.

His research interests include: Experimental researches for cardiotoxicity and heart failure, Clinical practice about cardiology and veterinary medicine.

• Research Scholarship at the Ohio State University, USA
• Coordinator of the Scientific Research Project Found in Ataturk University, Turkey
• Director of the Veterinary Hospital
• Head of the Department of Veterinary Internal Medicine
• Echocardiography and Digital Electrocardiography Practitioner

1. Nishijima Y, Feldman DS, Bonagura JD, et al. Canine nonischemic left ventricular dysfunction: a model of chronic human cardiomyopathy. Journal of Cardiac Failure. 2005; 11(8): 638-644. doi: 10.1016/j.cardfail.2005.05.006
2. Ozkanlar Y, Nishijima Y, da Cunha D, Hamlin RL. Acute effects of tacrolimus (FK506) on left ventricular mechanics. Pharmacological Research. 2005; 52(4): 307-312. doi: 10.1016/j.phrs.2005.05.003
3. Ozkanlar Y, Kijtawornrat A, Hamlin RL, Keene BW, Roche BM. Acute cardiovascular effects of tacrolimus in the isolated guinea pig heart. Journal of Vet Pharmacology Therapeutics. 2005; 28(3): 313-316. doi: 10.1111/j.1365-2885.2005.00631.x
4. Unver A, Rikihisa Y, Borku K, Ozkanlar Y, Hanedan B. Molecular detection and characterization of Ehrlichia canis from dogs in Turkey. Berliner und Münchener Tierärztliche Wochenschrift. 2005; 118: 300-304.
5. Kijtawornrat A, Ozkanlar Y, Keene BW, Roche BM, Hamlin DM, Hamlin RL. Assessment of drug-induced QT interval prolongation in conscious rabbits. Journal of Pharmacological and Toxicological Methods. 2006; 53(2): 168-173. doi: 10.1016/j.vascn.2005.04.013
6. Cunha DNQ, Buccellato M, Keene BW, et al. Electrocardiographic, hematologic, histopathologic, and recovery characteristics from repeated morphine-chloralose anesthesia in dogs. International Journal of Applied Research in Veterinary Medicine. 2008; 6: 191-200.
7. Simsek S, Ozkanlar Y, Balkaya I, Aktas MS. Microscopic, serologic and molecular surveys on Dirofilaria immitis in stray dogs, Turkey. Veterinary Parasitology. 2011; 183(1-2): 109-113. doi: 10.1016/j.vetpar.2011.06.012
8. Ozkanlar Y, Aktas MS, Turkeli M, et al. Effects of ramipril and darbepoetin on electromechanical activity of the heart in doxorubicin-induced cardiotoxicity. International Journal of Cardiology. 2014; 173(3): 519-521. doi: 10.1016/j.ijcard.2014.03
9. Ozkanlar Y, Nishijima Y, da Cunha D, Ulas N, Degirmencay S, Hamlin RL. A clinical application of the “brody effect”. Heart Res Open J. 2015; 2(3): 95-99. doi: 10.17140/HROJ-2-116

Mohamed Shehata, MD, FESC, FSCAI

Lecturer and Consultant of Cardiology
Ain Shams University
Khalifa El-Maamoun St, Cairo
Cairo Governorate 11566, Egypt

BiographyResearch InterestScientific ActivitiesPublications

Dr. Shehata was graduated from Ain Shams University medical school, Cairo, Egypt. He went through the academic cascade till being assigned as a Lecturer of Cardiology in the same institute. His duties included supervision of the Adult Cardiac Intervention Cath Lab & the Coronary Care Unit in Ain shams University hospital.

His research interests include: Adult coronary intervention, Patients management in coronary care unit, Acute cardiac care, Clinical cardiovascular pharmacology.

Professional Memberships & Fellowships

• Fellow of European Society of Cardiology (ESC)
• Fellow of The Society for Cardiovascular Angiography and Interventions (SCAI)
• Member of Acute Cardiac Care Association (ACCA)
• Member of European Association of Percutaneous Coronary Intervention (EAPCI)

International Publications:

1. Shehata M, Hamza M. Impact of High Loading Dose of Atorvastatin in Diabetic Patients with Renal Dysfunction Undergoing Elective Percutaneous Coronary Intervention: A Randomized Controlled Trial. Cardiovasc Ther. 2015. doi: 10.1111/1755-5922.12108
2. Shehata M. Value of Two-Dimensional Strain Imaging in Prediction of Myocardial Function Recovery after Percutaneous Revascularization of Infarct-Related Artery. Echocardiography. 2014. doi: 10.1111/echo.12704
3. Shehata M. Relation between ischemic threshold measured during dobutamine stress echocardiography and coronary angiographic features. Kardiol Pol. 2014. doi: 10.5603/KP.a2014.0111
4. Shehata M. Late re-assessment of myocardial viability after acute myocardial infarction: Is there still a chance? per title. Experimental & Clinical Cardiology. 2014; 20(1): 1062-1092.
5. Shehata M. Atropine first is safer than conventional atropine administration in older people undergoing dobutamine stress echocardiography. Ther Adv Cardiovasc Dis. 2014; 8(5): 176-184. doi: 10.1177/1753944714538112
6. Shehata M. Accelerated dobutamine stress testing: Feasibility and safety in patients with moderate aortic stenosis. The Egyptian Heart Journal. 2014. doi: 10.1016/j.ehj.2014.04.002
7. Shehata M. Impact of trimetazidine on incidence of myocardial injury and contrast-induced nephropathy in diabetic patients with renal dysfunction undergoing elective percutaneous coronary intervention. Am J Cardiol. 2014; 114(3): 389-394. doi: 10.1016/j.amjcard.2014.04.052
8. Shehata M. Cardioprotective effects of oral nicorandil use in diabetic patients undergoing elective percutaneous coronary intervention. J Interv Cardiol. 2014; 27(5): 472-481. doi: 10.1111/joic.12142
9. Shehata M. Cardioprotective effects of intracoronary adenosine in diabetic patients undergoing elective percutaneous coronary intervention. Minerva Cardioangiol. 2014; 62(6): 461-471. doi: 10.1111/joic.12142
10. Shehata M. Angiographic and Clinical Impact of Successful Manual Thrombus Aspiration in Diabetic Patients Undergoing Primary PCI. Int J Vasc Med. 2014; 2014: 263926. doi: 10.1155/2014/263926
11. Shehata M. Cardioprotective Effects of Oral Trimetazidine in Diabetic Patients With Anterior Wall Myocardial Infarction Treated With Thrombolysis. Cardiology Research. 2014; 5(2): 58-67. doi: 10.14740/cr330w
12. Shehata M, AbdElhalim B, Hanna H, Nabih M. Postoperative Tachyarrhythmias: On-Pump versus Off-Pump Coronary Artery Bypass Grafting. ISRN Vascular Medicine. 2014. doi: 10.1155/2014/659706
13. Shehata M. Nicorandil: what is beyond the anti-anginal action?. Heart Res Open J. 2015; 2(4): e6-e8. doi: 10.17140/HROJ-2-e003

Ayman Khairy Mohamed Hassan, MD, PhD, FESC

Lecturer of Cardiovascular Medicine
Department of Cardiology
Assiut University Hospitals
Assiut 71526, Egypt

BiographyResearch InterestScientific ActivitiesPublications
Education:

• July 2010: MD in Cardiovascular Medicine, Faculty of Medicine, Assiut University, Egypt
• January 2009: PhD in Cardiovascular Medicine, Faculty of Medicine, Leiden University , the Netherlands
• May 2004: Master Degree (M.Sc) in Cardiovascular medicine, Faculty of Medicine, Assiut University, Egypt
• September 1999: M.B.B.Ch in Medicine and Surgery, Faculty of Medicine, Assiut University, Egypt


Employment History:

• 9/2012-Present: Vice-director of Assiut University Hospitals, Chief of Health Care Quality Unite (HCQU), Assiut University Hospitals
• 9/2010- Present: Lecturer of cardiology, Assiut University
• 6/2009 - 9/2012: Executive Director of Assiut university catheterization laboratory, Assiut University
• 11/2004 to 8/2010: Associate lecturer, Assiut University
• 3/2004 - 11/2004: Demonstrator, Assiut University
• 3/2001 - 3/2004: Resident in Cardiology Department (Registrar), Assiut University Hospitals
• 3/2000 to 2/2001: House officer, Assiut University Hospitals

His research interests include: Evidence based Management of acute coronary syndromes and primary angioplasty, Hospital quality and accreditation systems.

Membership in Professional Societies:

• 2008-Present: Fellow of European Society of Cardiology
• 2008-Present: Fellow of European Association of Percutaneous Cardiovascular interventions (EAPCI)
• 2005-Present: Membership of the Egyptian Society of Cardiology
• 2005-Present: Member of the Egyptian Society of Atherosclerosis
• 2002-Present: Member & Fundador of the Egyptian Resuscitation Council
• 2002-Present: Member of European Resuscitation Council as an Official instructor
• 1999-Present: Membership of the Egyptian Medical Syndicate (EMS)

1. Hassan AKM, Liem SS, van der Kley F, et al. In-Ambulance Abciximab Administration in STEMI Patients Prior to Primary PCI is Associated with Smaller Infarct Size, Improved LV Function and Lower Incidence of Heart Failure: Results from the Leiden MISSION! Acute Myocardial Infarction Treatment Optimization Program. Catheterization and Cardiovascular Interventions. 2009; 74(2): 335-343. doi: 10.1002/ccd.21980
2. Hassan AKM, Jukema W, van der Laarse A, et al. Incidence, patient’s characteristics and predictors of aborted myocardial infarction in patients undergoing primary PCI: prospective study comparing pre- and in-hospital abciximab pretreatment. EuroInterv.2009; 4: 662-668. doi: 10.4244/EIJV4I5A110
3. Hassan AKM, Bergheanu SC, Stijnen T, et al. Late stent malapposition risk is higher after drug-eluting stent compared with bare-metal stent implantation and associates with late stent thrombosis. Eur Heart J.2010: 31(10): 1172-1180. doi: 10.1093/eurheartj/ehn553
4. Hassan AKM, Bergheanu S, Stijnen T, et al. Late Acquired Stent Malapposition is Higher After Drug-Eluting Stent Compared to Bare-Metal Stent Implantation and is Associated with (Very) Late Stent Thrombosis: Meta-Analysis and Systematic Review. American Journal of Cardiology. 2008; 102(8A): 1981. doi: 10.1093/eurheartj/ehn553
5. Bergheanu SC, Hassan AKM, Jukema JW. Late stent malapposition: innocent phenomenon or major risk marker? European Heart Journal. 2010; 31(2): 260-261. doi: 10.1093/eurheartj/ehp510
6. Hassan AKM, Bergheanu SC, Hasan-Ali H, et al. Usefulness of peak troponin-t to predict infarct size and long-term outcome in patients with first acute myocardial infarction after primary percutaneous coronary intervention. American Journal of Cardiology. 2009; 103(6): 779-784. doi: 10.1016/j.amjcard.2008.11.031
7. Hassan AKM, Liem SS, van der Kley F, et al. In-ambulance Abciximab Facilitated Primary PCI is Associated with Smaller Enzymatic Infarct Size, Improved LV Function and Lower Incidence of Heart Failure at One Year Clinical Follow-up. American Journal of Cardiology. 2008; 102(8A): 671.
8. Bergheanu SC, Van der Hoeven BL, Hassan AKM, et al. Post-intervention IVUS is not predictive for very late in-stent thrombosis in drug-eluting stents. Acta Cardiologica. 2009; 64(5): 611-616.
9. Hasan-Ali H, Hassan AKM. Tissue-doppler assessment of the changes in longitudinal left and right ventricular functions after percutaneous mitral valvotomy. JACC. 2011; 58(20): B214-B215.
10. Hassan AKM, Hasan-Ali H, Demetry SR, et al. A new femoral compression device compared with manual compression for bleeding control after coronary diagnostic catheterizations. The Egypt Heart J. 2013; 66(3): 233-239. doi: 10.1016/j.ehj.2013.11.001
11. Othman AAA, Tohamy AM, Hassan AKM. Pulmonary embolism presented by syncope in a low-risk patient: a case report. 2013; 2: 257. doi: 10.12688/f1000research.2-257.v1
12. Hassan AKM, Hasan-Ali H, Demetry SR, et al. Early sheath removal after percutaneous coronary intervention using Assiut Femoral Compression Device is feasible and safe. Results of a randomized controlled trial. The Egypt Heart J. 2014; 67(1): 69-77. doi: 10.1016/j.ehj.2014.10.003
13. Hassan AKM, Demetry SR, Agban GW. Can exercise capacity assessed by the 6 minute walk test predict the development of major adverse cardiac events in patients with stemi after fibrinolysis? PLoS One. 2014; 9(6): e99035. doi: 10.1371/journal.pone.0099035
14. Abdel Rahman H, Hassan AKM, Abosetta AHS, et al. Increased left atrial stiffness in patients with atrial fibrillation detected by left atrial speckle tracking echocardiography. The Egyptian Heart Journal.2014. doi: 10.1016/j.ehj.2014.11.006

Hany Younan Azer Girgis, MD

Associate Professor of Cardiology
Fayoum University
Tawfik El-Hakeem, Al Fayoum, Fayoum Governorate, Egypt

BiographyResearch InterestScientific ActivitiesPublications

Dr. Girgis acquired his Doctorate (MD) degree of Cardiology (April 2004) and Master Degree of Cardiology (May 1999) from Ain Shams University, Egypt and Bachelor Degree of Medicine and Surgery (MBBCh) from Al-Minia University, Egypt (December 1992).
He has a work experience as Associate Professor of Cardiology, Fayoum University, Egypt from 28/7/2010 till present; Visiting Consultant of Cardiology: Alseef Hospital-Kuwait; Consultant of Echocardiography: ALFA Scan Imaging Centers, Cairo, from 28/9/2009 till 4/7/2011 and Consultant of Echocardiography: Cairo Scan Imaging Centers, Cairo, from April 2007 till April 2009. He is a Fellow of Cardiology: Helwan University Hospital, Cairo, from 16/1/2005 to 25/2/2006 and Specialist of Cardiology from 16/8/2000 to 15/1/2005; Resident of Cardiology: National Heart Institute, Cairo, from 14/1/2000 till 15/8/2000 and Resident of Cardiology and I.C.U: Dar El-Shefa Hospital, Cairo, from 4/11/1996 till 13/1/2000.
He published more than 20 papers in international journals. He is also involved in several international conferences where he presented many posters and case presentations.

His research interests include: Diagnostic imaging , speckle tracking echocardiography, Tissue Doppler echocardiography, Cardiac function in rheumatic valvular heart diseases, genetics and CAD.

Honors and Awards:

• Owner of ”the ideal doctor prize” presented from the Egyptian Medical Syndicate April 2005
• Owner of the third prize of the best case presented in the conference of the Echocardiography working group of the Egyptian Society of Cardiology (Cairo, 2006)
• Owner of the third prize of the best research presented in the conference of the Egyptian Society of Cardiology and Pan Arab Society of Cardiology (Alexandria, 2002)


Membership:

• Fellow of the European Society of Cardiology (FESC)
• Member of the American Society of Echocardiography (ASE)
• Member of the Canadian Society of Echocardiography (CSE)
• Member of the European Association of Cardiovascular Imaging (ECAVI)
• Certified RDCS from the American Registry for Diagnostic Medical Sonography (ARDMS)
• Member of the Egyptian Society of Cardiology

As a First Author:

1. Younan H. Role of two dimensional strain and strain rate imaging in assessment of left ventricular function in patients with rheumatic mitral stenosis and normal ejection fraction. Egyptian Heart Journal. 2014. doi: 10.1016/j.ehj.2014.07.003
2. Younan H, Razek GA, Elkhashab K, Abdelrasol H, Saad M. Relationship of endothelial nitric oxide synthase gene polymorphism with atherosclerotic coronary and carotid arterial disease in egyptian population. Egyptian Heart Journal. 2014. doi: 10.1016/j.ehj.2014.01.003
3. Younan H. Detection of subclinical right ventricular systolic dysfunction in patients with mitral stenosis by two dimensional strain and strain rate imaging. Egyptian Heart Journal. 2015; 67: 47-53. doi: 10.1016/j.ehj.2014.09.002
4. Younan H, Ragad T, El-Khashab K, Farag N. Impact of Gender Difference on PCI Outcome in Egyptian Diabetic Patients: Prospective Two Centers Registry Study. Egyptian Heart Journal. 2015; 67: 55-61. doi: 10.1016/j.ehj.2014.09.001
5. Younan H. Two dimensional speckle tracking echocardiography in detection of subclinical left ventricular systolic dysfunction in patients with severe aortic stenosis. Indian Heart Journal. 2014; 66(6): 602-606. doi: 10.1016/j.ihj.2014.10.400
6. Younan H. Usefulness of 2-dimensional mitral valve leaflets separation index as a new technique for assessment of mitral stenosis severity: comparison with planimetry and pht methods. Egyptian Heart Journal. 2010; 62(1): 187-195.
7. Younan H, El-Khashab K. Correlation of high sensitivity C-reactive protein to presence, extent and severity of angiographic coronary artery disease in patients with chronic stable angina. Egyptian Heart Journal. 2008; 60(1): 53-60.
8. Younan H. High sensitivity C-reactive protein: a novel and promising marker of degenerative aortic valve disease. Egyptian Heart Journal. 2007; 59(2): 241-248.


Further Publications:

9. Mashahet M, Younan H, El-Amir M, Mohamed A, Farawela H, El-Hamed AA. Cirrhotic cardiomyopathy in egyptian population. Journal of Applied Medical Sciences. 2014; 3 (3): 31-40.
10. Alsaddah J, Alkandari S, Younan H. Latrogenic left main coronary artery stenosis following aortic and mitral valve replacement. Heart Views. 2015; 16(1): 37-39. doi: 10.4103/1995-705X.153001
11. Abdelmoktader A, Younan H. Usefulness of pulsed wave tissue doppler imaging in assessment of left ventricular functions in children with beta-thalassemia major: a cross-sectional study. Indian J Pediatr. 80(9): 721-725. doi: 10.1007/s12098-013-1020-0
12. Shaker FE, El-Khashab K, Younan H, et al. Tissue doppler imaging versus conventional echocardiography in evaluation of diastolic function in diabetic patients. Life Science Journal. 2012; 9(4): 2256-2262.
13. Saad M, Younan H. Dual source CT coronary angiography. Diagnostic accuracy without the use of B blockers. The international version of the Egyptian Journal of radiology and nuclear medicine. 2011; 42: 281-287. doi: 10.1016/j.ejrnm.2011.07.001
14. Saad M, Younan H. Diagnostic accuracy of dual source CT coronary angiography in patients with high calcium score. The Egyptian Journal of radiology and nuclear medicine. 2010; 41(1): 319-325. doi:
15. Saad M, Younan H. Functional assessment of the left ventricle in patients with cardiac arrhythmia using dual source CT. The Egyptian Journal of radiology and nuclear medicine. 2010; 41(1): 181-190.
16. El-Khashab K, Elamir M, Younan H, Talaat, M, Hassan O. Homocysteine as a Risk Factor for Vascular Disease. Egyptian Heart Journal. 2007; 59(2): 263-270.
17. Fahmy M, Younan H. Non-invasive coronary imaging with 64-multislice CT coronary angiography in comparison to invasive coronary angiography. Egyptian Journal of radiology and nuclear medicine. 2009; 40(1): 61-68.
18. Shaheen HA, El-Khashab K, Younan H, et al. Cognitive impairment in heart failure patients. Egyptian Journal of neurology, psychiatry and neurosurgery. 2007; 44(1): 271-283.
19. Guindy R, Younan H, Osama M, Kamel Y, Abdelghafar T, Fahmy M. Regional mean systolic myocardial velocity estimation by real-time color doppler myocardial imaging: a new technique for quantifying regional systolic function during ischemia and following PTCA. Egyptian Heart Journal. 2005; 3: 105- 114.
20. Guindy R, Younan H, et al. Can doppler myocardial imaging myocardial velocity gradient predicts regional contractile recovery very early following ptca? a colored 2d doppler myocardial imaging study. Egyptian Heart Journal. 2005; 3: 95- 104.

Sadeer G. Al-Kindi, MD

Department of Medicine
University Hospitals Case Medical Center
Louis Stokes VA Medical Center
Case Western Reserve University
11100 Euclid Av, Cleveland, OH 44106, USA

BiographyResearch InterestScientific ActivitiesPublications

Dr. Al-Kindi received his MD with honors in research and academic distinction from Weill Cornell Medical College of Cornell University. He is currently pursuing his medical residency at University Hospitals Case Medical Center and Case Western Reserve University, Cleveland, Ohio. He is on the editorial board of the American Journal of Internal Medicine, the International Journal of Internal Medicine Research, Cancer Research Journal, and the American Journal of Clinical and Experimental Medicine. He has reviewed manuscripts for many international journals including Annals of Internal Medicine, the American Journal of Cardiology, and Bio Med Central Cancer.

His research interests include: Cardiomyopathy, Heart failure, Advanced treatments, Heart transplantation, Ventricular assist devices, Oncocardiology, Cardiotoxicity, Palliative care, General medicine.

Honors and Awards

• 05/2014: Department of Medicine Annual Research Award (Case Western Reserve University)
• 04/2013: Biomedical Research Award (Weill Cornell Medical College)
• 04/2013: Academic Excellence Award in Internal Medicine (Weill Cornell Medical College)
• 04/2012: Pierre Fabre Médicament Prize for Best Oral Presentation (Pan Arab Cancer Congress)
• 07/2010: Student Summer Research Internship (Weill Cornell Medical College)
• 06/2009: Howard Hughes Undergraduate Scholar (Howard Hughes Medical Institute)


Licensure

• 07/2013 - present: Ohio state training license (No. 57.022730)
• 04/2013 - present: Educational Commission on Foreign Medical Graduates Certification


Professional Memberships

• Academy of Medicine of Cleveland & Northern Ohio (AMCNO)
• International Iraqi Medical Association (IIMA)

1. Oliveira GH, Qattan M, Al-Kindi SG, Park SJ. Advanced heart failure therapy for patients with chemotherapy-induced cardiomyopathy. Circ Heart Fail. 2014; 7(6): 1050-1058. doi: doi: 10.1161/CIRCHEARTFAILURE.114.001292
2. Al-Kindi SG, Younes A, Qattan M, Oliveira GH. Preemptive cardioprotective strategies in patients receiving chemotherapy. Cur Cardiovasc Risk Rep. 2014; 8: 406-420. doi: 10.1007/s12170-014-0406-5
3. Al-Kindi SG, ElAmm C, Ginwalla M, Hoit B, Park, SJ, Oliveira GH. Heart transplant outcomes in patients with left ventricular non-compaction cardiomyopathy. J Heart Lung Transplant. 2014. doi: 10.1016/j.healun.2014.11.005
4. Deo SV, Al-Kindi SG, Oliveira GH. Management of advanced heart failure due to cancer therapy: the present role of mechanical circulatory support and cardiac transplantation. Cur Treat Option Cardiovasc Med. 2014. doi:
5. Ige M, Al-Kindi SG, Attizzani G, Costa MA, Oliveira GH. Percutaneous left ventricular restoration. Heart Fail Clinics. 2015. doi: 10.1016/j.hfc.2014.12.005
6. Al-Kindi SG, Al-Juhaishi T, Haddad F, Taheri S, Abi Khalil C. Cardiovascular disease research activity in the Middle East: a bibliometric analysis. Therap Adv Cardiovasc Dis. 2015. doi:
7. Oliveira GH, Al-Kindi SG, Bezerra HG, Costa MA. Left ventricular restoration devices. J CardiovascTransl Res. 2014; 7(3): 282-291. doi: 10.1007/s12265-014-9552-x.
8. Al-Kindi SG, Tafreshi R. Real-time detection of myocardial infarction by evaluation of ST segment in digital ECG. J Med Imaging Health Inf. 2011; 1: 225-230. doi: 10.1166/jmihi.2011.1032
9. Al-Kindi SG, Ali F, Farghaly A, Nathani M, Tafreshi R. Towards real-time detection of myocardial infarction by digital analysis of electrocardiograms. Biomedical Engineering (MECBME), IEEE Explore. 2011; 454-457. doi: 10.1109/MECBME.2011.5752162
10. Abu Zeinah GF, Al-Kindi SG, Allam A, Hassan AA. Hyponatraemia in cancer: association with type of cancer and mortality. European Journal of Cancer Care. 2015; 24(2): 224-231. doi: 10.1111/ecc.12187
11. Hassan A, Allam A, Al-Kindi SG, Abu Zeinah G, Eziada S. Knowledge, Attitudes and Practices of Oncology Nurses towards Complementary and Alternative Medicine for Cancer Care in Qatar. J Anesth Clin Res. 2014; 5: 12. doi: 10.4172/2155-6148.1000477
12. Al-Kindi SG, Abu Zeinah GF, Hassan AA. Palliative care knowledge and attitudes among oncology nurses in Qatar. Am J Hosp Palliat Med. 2013; 31(5): 469-474. doi: 10.1177/1049909113489874
13. Abu Zeinah GF, Al-Kindi SG, Hassan AA. Attitudes of medical oncologists in Qatar toward palliative care. Am J Hosp Palliat Med. 2013; 30(6): 548-551. doi: 10.1177/1049909112461168
14. Al-Kindi SG, Abu Zeinah GF, Hassan AA. Pattern of hospitalization of patients with cancer in an acute palliative care setting: Qatar’s experience. Am J Hosp Palliat Med. 2013; 30(1):25-28. doi: 10.1177/1049909112439931
15. Abu Zeinah GF, Al-Kindi SG, Hassan AA. Middle East experience in palliative care. Am J Hosp Palliat Med. 2013; 30(1): 94-99. doi: 10.1177/1049909112439619
16. Al-Juhaishi T, Al-Kindi SG, Gehani AA. Khat: A widely used drug of abuse in the Horn of Africa and the Arabian Peninsula. Qat Med J. 2012; 21(2): 3-6. doi: 10.5339/qmj.2012.2.5
17. Al-Kindi SG, Al-Juhaishi T, Al-Saffar AJ. Community attitudes towards people with Down syndrome: a sample from Iraq. Pub Hlth Res. 2012; 2(4): 102-105. doi: 10.5923/j.phr.20120204.06
18. Al-Kindi SG, Al-Kindi G.A. Breast sonogram and mammogram enhancement using hybrid and repetitive smoothing-sharpening technique. Biomedical Engineering (MECBME), IEEE Explore. 2011; 446-449. doi: 10.1109/MECBME.2011.5752160
19. Al-Kindi SG. Lack of reversibility for NOACs. Glob Cardiol Sci Pract. 2014; 1. doi: 10.5339/gcsp.2014.1

Xiaowen Liu, PhD

Department of Cardiology
Boston Childrens Hospital
Harvard Medical School
Boston, MA 02115, USA

BiographyResearch InterestScientific ActivitiesPublications
EDUCATION

• Aug 2009- March 2014 Departments of Pharmacology and Dermatology, University of Illinois at Chicago, Chicago, IL
• Sep 2006- July 2009 Institute of Zoology, ChineseAcademy of Sciences
• Sep 2002- July 2006 College of Life Science and Technology, BeijingUniversity of Chemical Technology


CURRENT EMPLOYMENT

• March 2014-present Department of Cardiology, Boston Children’s Hospital, Harvard Medical School

Her research interests include: Primary cilia, Inflammation and Cardiovascular Disease, Ion channels especially TRRP channels, Stem cells, Signal transduction, G protein coupled receptors, Vesicle trafficking, Cell Polarity , Cell Migration.

SCHOLARSHIPS, AWARDS and PRESENTATIONS

• 2012.9 The Albert and Doris Woeltjen Student Achievement Award, Department of Pharmacology
• 2012.4 Deans Scholar Award, Graduate College of University of Illinois at Chicago
• 2012.4 Presentation on Student Research Forum of Department of Pharmacology
• 2012.3 Poster Presentation on Chicago Cytoskeleton Meeting at Northwestern University
• 2011.3 Presentation on Student Research Forum of Department of Pharmacology
• 2006.7 Honored student of Chinese Academy of Sciences
• 2005.4 Second class scholarship of BUCT
• 2004.12 Honored student of College of life science and technology, BUCT
• 2004.10 Second class scholarship of BUCT
• 2004.4 First class of National scholarship of China
• 2003.2 Second class of National scholarship of China

1. Liu X, Ma B, Malik AB, Tang H, et al. Bidirectional regulation of neutrophil migration by MAP kinases. Nature Immunology. 2012; 13: 457-464. doi: 10.1038/ni.2258.
2. Liu X, Yang T, Suzuki K, et al. Moesin and Myosin Phosphatase Confine Neutrophil Orientation in a Chemotactic Gradient. J Exp Med. 2014.

Muralidhar Padala, PhD

Director and Assistant Professor
Structural Heart Research & Innovation Lab
Division of Cardiothoracic Surgery
Emory University
380B, Northyards Blvd
Atlanta, GA 30313, USA

BiographyResearch InterestScientific ActivitiesPublications
EMPLOYMENT:

• Aug 2014 to present: Program Faculty, Biomedical Engineering, Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology
• May 2010 to present: Assistant Professor, Division of Cardiothoracic Surgery, Director, Structural Heart Disease Research & Innovation Lab, Emory University School of Medicine
• Jan 2003 - Apr2004: Intern, Hypersonic Propulsion Division, Indian Defense Research and Development Organization, Hyderabad, India


EDUCATION:

• Feb 2012 - Dec2012 Postdoctoral research fellowship [Funded by a competitive career development award from Leducq Fondation in Paris], Heart Science Center, Imperial College London, UK
Thesis: Molecular mechanisms of mitral valve prolapse Aug 2004 May
• 2010: Ph.D. in Bioengineering [Funded by a fellowship from the American Heart Assoc], Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, USA
Thesis: Mitral valve mechanics after surgical repair
• Aug 2006 - May 2008: M.S. in Mechanical Engineering, Woodruff Department of Mechanical Engineering, Georgia Institute of Technology, Atlanta, USA
Major: Mechanics Minor: Biomaterials
• May 2000 - May2004: B.E in Mechanical Engineering, Osmania University, Hyderabad, India, GPA: 4.0/4.0, Highest honors
Thesis: Computational modeling of nonpremixed combustion in supersonic rocket engines

His research interests include:
Structural heart and valve disease, involving lesions that impact the structure, function and biology of the heart valves, and the myocardium are the focus of my research. His interest is in understanding the mechanisms underlying the initiation and progression of disease in these structures, their biological remodeling from initiation of the structural lesion to complete failure, and in developing therapies specific to these lesions to control their progression. Their ultimate goal is to improve our knowledge of disease initiation and propagation, and innovate new therapeutic strategies and devices to treat patients.
(i) Functional mitral regurgitation Mitral regurgitation developing in patients after a heart attack, impairs cardiac function and increases cardiac morbidity and mortality. His laboratory was investigating the pathogenic mechanisms of functional mitral regurgitation, and developing novel surgical and transcatheter devices to address this challenging valvular lesion.
(ii) Mitral valve prolapse Mitral valve prolapse occurs among 23% of all adult Americans, which when left untreated causes increased risk of sudden cardiac death. His laboratory was investigating the pathogenic mechanisms underlying mitral valve prolapse, and the biomechanical parameters that cause progressive valve deterioration in this disease state.
(iii) Timing of mitral valve repair and its impact on left ventricular remodeling Optimal timing of mitral valve repair, whether functional mitral regurgitation and due to mitral valve prolapse, is necessary to rescue the ventricle from failing. His laboratory is investigating the time course of left ventricular remodeling in mitral valve disease, and for markers to identify the optimal timing of mitral valve repair to achieve best rescue of the ventricle.
(iv) TypeB aortic dissection TypeB aortic dissection is a structural tear of the aorta that develops at regions of atherosclerotic plaque, and propogates through the entire distal aorta, and is associated with up to 25% in hospital mortality. His laboratory was investigating the impact of typeB aortic dissection on the aortic hemodynamics, and the impact of endovascular aortic repair on hemodynamics.

HONORS AND AWARDS

• 2014 American Heart Association Scientist Development Grant
• 2014 Final 10, Med Tech Idol Competition, IN3 Dublin
• 2012 Emory University Innovation of the Year Award
• 2011 Leducq Fondation Career Development Award
• 2011 1st place, SEBIO Business Plan Competition, Duke University
• 2009 1st place, Ventura Business Plan Competition, India
• 2009 Social Relevance Award, Ventura Business Plan Competition
• 2009 Gandy Diaz Teaching Fellowship
• 2008 American Heart Association Pre Doctoral Fellowship Grant
• 2004 Highest honors in the graduating class

1. Kalra K, Wang Q, McIver BM, et al. Temporal changes in interpapillary muscle dynamics as an active indicator of mitral valve and left ventricular interaction in ischemic mitral regurgitation in humans. Journal of the American College of Cardiology. 2014; 64(18): 1867-1879. doi: 10.1016/j.jacc.2014.07.988
2. Miragoli M, Yacoub MH, ElHamamsy I, et al. Side specific mechanical properties of valve endothelial cells. American Journal of Physiology Heart and Circulatory Physiology. 2014; 307(1): H1524. doi: 10.1152/ajpheart.00228.2013
3. Padala M, Sweet M, Hooson S, Thourani VH, Yoganathan AP. Hemodynamic Comparison of Mitral Valve Repair: techniques for a flail anterior leaflet. Journal of Heart Valve Disease. 2014; 23(2): 171-176.
4. Padala M, Gyoneva LI, Thourani VH, Yoganathan AP. Impact of mitral valve geometry on hemodynamic efficacy of surgical repair in secondary mitral regurgitation. Journal of Heart Valve Disease. 2014; 23(1): 79-87. doi:
5. Lam A, ClementGuinaudeau S, Padala M, Eisner R, Thourani VH, Oshinski JO. Post Surgical Hemodynamics of Aortic Valve Bypass Operation Evaluated with Phase Contrast Magnetic Resonance Imaging. Journal of Magnetic Resonance in Medicine. 2014; 40(4): 899-905. doi: 10.1002/jmri.24423.
6. Thourani VH, Gunter RL, Hurst S, et al. Postoperative Warfarin Following Mitral Valve Repair or Bioprosthetic Valve Replacement. Journal of Heart Valve Disease. 2013; 22(5): 716-723. doi:
7. Padala M, Cardinau B, Gyoneva LI, Thourani VH, Yoganathan AP. Comparison of artificial neochordae and native chordal transfer in the repair of a flail posterior mitral leaflet: an experimental study. Annals of Thoracic Surgery. 2013; 95(2):629-633. doi: 10.1016/j.athoracsur.2012.09.055
8. Yamauchi H, Vasilyev NV, Marx GR, et al. Right Ventricular Papillary Muscle Approximation as a Novel Technique of Valve Repair for Functional Tricuspid Regurgitation in an Ex Vivo Porcine Model. Journal of Thoracic and Cardiovascular Surgery. 2012; 144(1):235-242. doi: 10.1016/j.jtcvs.2012.01.028
9. Padala M, Jimenez JH, Yoganathan AP, Chin A, Thourani VH. Transapical Beating Heart Cardioscopy Technique for OffPump Visualization of Heart Valves. Journal of Thoracic and Cardiovascular Surgery. 2012; 144(1): 2314. doi: 10.1016/j.jtcvs.2011.11.038
10. Balachandran K, Hussain S, Yap CH, Padala M, Chester AH, Yoganathan AP. Elevated Cyclic Stretch and Serotonin Result in Degenerative Aortic Valve Remodeling via a Mechanosensitive 5HT2A Receptor Dependent Pathway. Cardiovascular Pathology. 2012; 21(3): 206-213 doi: 10.1016/j.carpath.2011.07.005
11. Padala M, Gyoneva LI, Yoganathan AP. Effect of anterior strut chordal transection on the force distribution on the marginal chordae of the mitral valve. Journal of Thoracic and Cardiovascular Surgery. 2012; 144(3): 624-633. doi: 10.1016/j.jtcvs.2011.10.032
12. Weiler M, Yap CH, Balachandran K, Padala M, Yoganathan AP. Regional analysis of dynamic deformation characteristics of native aortic valve leaflets. Journal of Biomechanics. 2011; 44(8): 145965 doi: 10.1016/j.jbiomech.2011.03.017
13. Padala M, Thourani VH, Keeling BW. Innovations in Heart Valve Therapies, Invited review article. Circulation Journal, Journal of the Japanese Circulation Society, Circulation Journal. 2011; 75(5): 102841 doi:
14. Delmo Walter EM, Vasilyev NV, Sill B, et al. Creation of a tricuspid valve regurgitation model from tricuspid annular dilatation using the cardioport video assisted imaging system. Journal of Heart Valve Disease. 2011; 20: 184-188 doi:
15. Padala M, Sarin EL, Babaliaros V, Block P, Thourani VH. Engineering Review of Transcatheter Aortic Valve Technologies. Cardiovascular Engineering and Technology. 2010; 1(1): 77-87. doi: 10.1007/s13239-010-0008-4
16. Padala M, He Z, Sacks MS, Liou SW, Jimenez JH, Yoganathan AP. Mechanics of the mitral valve strut chordae insertion region. Journal of Biomechanical Engineering. 2010; 132(8): 081004. doi: 10.1115/1.4001682
17. Padala M, Hutchison R, Croft LR, et al. Saddle shape of the mitral annulus reduces systolic strains on the P2 segment of the posterior mitral leaflet. Annals of Thoracic Surgery. 2009; 88(5):1499-1504. doi: 10.1016/j.athoracsur.2009.06.042
18. Padala M, Powell SN, Croft LR, Thourani VH, Yoganathan AP, Adams DH. Mitral Valve Hemodynamics after repair of acute posterior leaflet prolapse: quadrangular resection versus triangular resection versus neochordoplasty. Journal of Thoracic and Cardiovascular Surgery. 2009 ; 138(2): 309-315. doi: 10.1016/j.jtcvs.2009.01.031
19. Erek E, Padala M, Pekkan K, et al. Mitral Web - A New Concept for Mitral Valve Repair: improved engineering desigh and invitro studies. Journal of Heart Valve Disease. 2009; 18(3): 3006. doi:
20. Padala M, Vasilyev N, Owen Jr JW, et al. Cleft Closure and Undersizing Annuloplasty Improve Mitral Repair in Atrioventricular Canal Defects. Journal of Thoracic and Cardiovascular Surgery. 2008; 136(5): 124-139. doi: 10.1016/j.jtcvs.2008.05.043
21. Sucosky P, Padala M, Elhamalli A, Balachandran K, Jo H, Yoganathan AP. Design of an Exvivo Culture System to Investigate the Effects of Shear Stress on Cardiovascular Tissue. Journal of Biomechanical Engineering. 2008; 130(3): 035001. doi: 10.1115/1.2907753.
22. Jimenez JH, Liou SW, Padala M, et al. A saddle shaped annulus reduces strains in the central region of the anterior mitral valve leaflet. Journal of Thoracic and Cardiovascular Surgery. 2007; 134(6): 15628. doi: http://dx.doi.org/10.1016/j.jtcvs.2007.08.037

Gustavo S. Masson, PhD

Heart and Vascular Center
Brigham and Womens Hospital
Harvard Medical School
USA

BiographyResearch InterestScientific ActivitiesPublications
Education and Training


• (2003-2008) BSc (Physical Education and Sports; Rio de Janeiro State University - Rio de Janeiro/Brazil)
• (2008-2010) MSc (Cellular and Molecular Biology; Oswaldo Cruz Institute-Rio de Janeiro/Brazil)
• (2010-2014) PhD (Human Physiology; University of Sao Paulo-Sao Paulo/Brazil)
• (2013-2014) Research Associate (Comparative Biomedical Science Department-Louisiana State University)
• (2014-Present) Post-doctoral Research Fellow (Brigham and Womens Hospital-Harvard Medical School)

His research interests include: Heart research.

AWARDS


• Amil Prize (2012) - XX Brazilian Hypertension Congress (Sao Paulo/Brazil)
• Travel Grant Award (2010) -Heart Failure European Congress (Berlin/Germany)

Original Investigations


1. Masson GS, Rodrigues TSC, Yshii L, et al. Time-dependent effects of training on cardiovascular control in spontaneously hypertensive rats: role for brain oxidative stress and inflammation and baroreflex sensitivity. PLoS One. 2014; 9(5): 94927. doi: 10.1371/journal.pone.0094927
2. Nair AR, Masson GS, Ebenezer PJ, Del Piero F, Francis J. Role of TLR4 in lipopolysaccharide-induced acute kidney injury: Protection by blueberry. Free Radic Biol Med. 2014; 71: 16-25. doi: 10.1016/j.freeradbiomed.2014.03.012
3. Masson GS, Correa, L, Sanches E, et al. Influence of Supervised Exercise Therapy on Blood Pressure in Patients with cardiovascular disease. SOCER J. 2006; 19: 302-307.
4. Masson GS, Michelini LC. Autonomic dysfunction, sympathetic hyperactivity and the development of end-organ damage in hypertension: Multiple benefits of exercise training. Heart Res Open J. 2015; 2(2): 60-69.


Book Chapters


1. Moraes GS, Oliveira FOR Jr, Masson G, et al. Cellular and Molecular Biology Series. Experimental Methods in protein studies. 1st ed. Rio de Janeiro: Oswaldo Cruz Institute. 2013.

Brian C. Cooley, PhD

Associate Professor
Department of Pathology and Laboratory Medicine
Faculty Director, Rodent Advanced Surgical Models Core Lab
McAllister Heart Institute
University of North Carolina
Chapel Hill, NC 27599, USA

BiographyResearch InterestScientific ActivitiesPublications

Dr. Cooley is currently an Associate Professor at the University of North Carolina and the Faculty Director of the McAllister Heart Institute Surgical Core Lab. Prior to this he worked at the Medical College of Wisconsin for nearly 3 decades, involved in a number of studies on a variety of topics, which included rodent models of heart transplantation. He runs a Core Lab at UNC that provides a wide variety of experimental surgical procedures to collaborators, from standard models of coronary artery-based ischemia/reperfusion and vascular injuries, to murine organ transplantation (heart, kidney, small bowel, composite tissue transfer), to many unique and custom-designed surgical manipulations. His main areas of research are thrombosis and vascular biology. He has developed novel models for inducing thrombosis and for intravital fluorescence imaging of thrombus development. Recent applications of these models and evaluative measures have explored the roles of a number of thrombosis-associated factors in augmenting or inhibiting clot formation: tissue factor pathway inhibitor, polyphosphate, surface-exposed collagen, elevated prothrombin, and several standard and new anti-platelet agents and anticoagulants. Continuing studies are exploring related thrombus-modulating factors and novel approaches to preventing thrombosis. In vascular biology, he has been focusing on a major complication of bypass vein grafting, the development of neointimal thickening and inward remodeling of the graft that leads to vein graft stenosis. The sources of cells within the neointimal layer as well as the causative factor(s) for neointimal development are still not well characterized. He has recently reported a novel finding, that endothelial cells originating from the vein graft undergo transdifferentiation into a smooth muscle phenotype within the developing neointima upon grafting into an arterial environment. This endothelial-mesenchymal transdifferentiation process is mediated by TGF-beta, following a Smad2/3-Slug cell signaling pathway and contributes prominently to neointima-based vein graft stenosis.

His research interests include: Thrombosis and vascular biology.

PROFESSIONAL ORGANIZATIONS

• American Association for the Advancement of Science
• International Society for Thrombosis and Haemostasis
• North American Society for Thrombosis and Hemostasis


COMMITTEES:

• McAllister Heart Institute Executive Committee: 2013-present
• UNC IACUC: 2014-present

1. Swartzwelder HS, Johnson CT, Cooley BC, Howell WE, Dyer RS. Alcohol-induced alterations in hippocampal afterdischarges and afterdischarge thresholds: Dose response studies. Neurobehav Toxicol. 1980; 1: 253-258.
2. Cooley BC, Hansen FC, Dellon AL. The effect of temperature on ischemic tolerance of experimental free flaps. J Microsurgery. 1981; 3: 11-14. doi: 10.1002/micr.1920030105
3. Gould E, Cooley BC, Barnick P. Echolocation by young bats on their initial and subsequent flights. Developmental Psychobiol. 1981; 14: 41-54.
4. Dellon AL, Curtis RM, Cooley BC. Lysis of venous clots by local intra-arterial Thrombolysin injection in the rat. Annals Plast Surg. 1981; 7: 38-43.
5. Cooley BC, Jones MM, Dellon AL. Comparison of efficacy of Thrombolysin, streptokinase, and urokinase in a femoral vein clot model in rats. Microsurgery. 1983; 4: 1-4. doi: :10.1002/micr.1920040105
6. Cooley BC, Morgan RF, Dellon AL. Thrombolytic reversal of no-reflow phenomenon in rat free flap model. Surgical Forum. 1983; 34: 638-640.
7. Cooley BC, Hansen FC. Microvascular repair following local crush and avulsion vascular injury. Microsurgery. 1985; 6: 46-48.
8. Jarow JP, Cooley BC, Marshall FF. Laser-assisted vasal anastomosis in the rat and man. J Urology. 1986; 36: 1132-1135.
9. Cooley BC, Ruas EJ, Wilgis EFS. Scanning electron microscopy of crush/avulsion arterial trauma: Effect of heparin and aspirin administration. Microsurgery. 1987; 8: 11-16.
10. Cooley BC, Gould JS. Experimental models for evaluating antithrombotic therapies in replantation microsurgery. Microsurgery. 1987; 8: 230-233.
11. Schlaff WD, Cooley BC, Shen W, Rock J, King T. A rat uterine horn model of genital tract wound healing. Fertility Sterility. 1987; 48: 866-872.
12. Stein BS, Cooley BC. CO2 laser-assisted microscopic vasovasostomy. J Endourology. 1988; 2: 299-307.
13. Wright J, Cooley BC, Duwell J, Sieber-Blum M. Migration-related changes in the cytoskeleton of cultured neural crest cells visualized by the monoclonal antibody I-5G9. J Neurosci Res. 1988; 21: 148-154.
14. Cooley BC, Tadych KL, Gould JS. Reperfusion of free flaps during normothermic ischemic storage. J Reconstr Microsurg. 1990; 6: 49-53.
15. Khouri RK, Cooley BC, Kenna DM, Edstrom L. Thrombosis of microvascular anastomoses in traumatized vessels: Fibrin versus platelets. Plastic Reconstr Surg. 1990; 86: 110-117.
16. Cooley BC, Ma L, Gould JS. Rat femoral vein-to-vein grafts as a microvascular practice model: Factors that influence patency. Microsurgery. 1991; 12: 43-45.
17. Cooley BC, Ma L, Groner JP, Hoer SR, Dollinger BM, Hanel DP. An experimental study of the influence of arterial trauma upon dependent distal tissue survival. Microsurgery. 1991; 12: 86-88.
18. Cooley BC, Gould JS. Topically applied antithrombotic agents offer a new therapeutic approach to the prevention of microvascular thrombosis. Microsurgery. 1991; 12: 281-287.
19. Cooley BC. Rat models for investigating clinical problems in free flap surgery. Revista de Orthoped y Traumatol (Spain). 1991; 35 IB: 406-415.
20. Cooley BC. Standardization of microsurgery training. Revista de Orthoped y Traumatol (Spain). 1991; 35 IB: 401-405.
21. Savoie FH, Cooley BC, Gould JS. Evaluation of pharmacological agents on crush-avulsion arterial injuries: a scanning electron microscopy study. Microsurgery. 1991; 12: 292-300.
22. Cooley BC, Hanel DP, Gould JS, Li XL, Smith JW. Antithrombotic benefit of subendothelium-bound urokinase: An experimental study. J Hand Surg. 1992; 17A: 235-244.
23. Rumbolo PM, Cooley BC, Hanel DP, Gould JS. Comparison of the influence of intralumenal irrigation solutions on free flap survival. Microsurgery. 1992; 13: 45-47.
24. Li XL, Cooley BC, Gould JS. The influence of topical heparin on stasis-induced thrombosis of microvascular anastomoses. Microsurgery. 1992; 13: 72-75.
25. Ma L, Li XL, Cooley BC, Gould JS. Microvascular salvage procedures with adjuvant antithrombotic therapy for restitution of patency in a rat model of vein thrombosis. J Reconstr Microsurg. 1992; 8: 201-205. doi: 10.1055/s-2007-1006701
26. Cooley BC, Gould JS. Investigation of the effect of venous flow alterations upon patency of rat femoral vein anastomoses. Microsurgery. 1992; 13: 138-142.
27. Cooley BC, Hanel DP, Anderson RB, Foster MD, Gould JS. The influence of diabetes upon free tissue transfer: Part I. Flap survival and anastomotic healing. Annals Plast Surg. 1992; 29: 58-64.
28. Cooley BC, Hanel DP, Ma L, Li XL, Gould JS. The influence of diabetes upon free tissue transfer: Part II. The effect of ischemia on flap viability. Annals Plast Surg. 1992; 29: 65-69.
29. Li XL, Cooley BC, Gruel SM, Ye Z, Gould JS. The rat cutaneous maximus free muscle flap model: Comparison to the latissimus dorsi flap. Microsurgery. 1992; 13: 208-213.
30. Cooley BC, Li XL, Dzwierzynski W, et al. The de-endothelialized rat carotid arterial graft: A versatile experimental model for the investigation of arterial thrombosis. Thrombosis Research. 1992; 67: 1-14. doi: http://dx.doi.org/10.1016/0049-3848(92)90252-6
31. Cooley BC, Fowler JD, Gould JS. Influence of physiologic alteration of fibrinogen levels upon micro-venous anastomotic patency. Microsurgery. 1992; 13: 299-303.
32. Cooley BC, Dollinger BM, Mlsna JS, Gould JS. Maintenance of patency after vascular trauma by topical irrigation with a peptide homologous to the carboxy-terminus of the fibrinogen gamma-chain. J Hand Surg. 1992; 17A: 1044-1051.
33. Cooley BC, Gould JS. The influence of age upon rat free flap survival following prolonged cold ischemia. Annals Plast Surg. 1993; 30: 57-59.
34. Li XL, Cooley BC, Gould JS. Ex vivo perfusion with anticoagulated blood decreases ischemia/reperfusion injury. J Hand Surg. 1993; 18A: 629-634. doi: http://dx.doi.org/10.1016/0363-5023(93)90306-N
35. Li XL, Cooley BC, Gould JS. Effect of age upon ischemia-induced muscle injury in a rat muscle free flap model. J Surg Research. 1993; 55: 193-200. doi: http://dx.doi.org/10.1006/jsre.1993.1129
36. Kulwicki KJ, Harris GF, Cooley BC. A system for evaluation of surgical hand tremor. Proc Ann Internat Conf IEEE Eng Med Biol Soc. 1993; 15: 977-978.
37. Ozbek M, Deune EG, Cooley BC, Khouri RK. Experimental reproduction of free flap errors: A new model of thrombosis. Annals Plast Surg. 1994; 32: 474-477.
38. Cooley BC. Laser-assisted microvascular anastomoses: In vitro and in vivo evaluation. Revista de Orthoped y Traumatol (Spain). 1994; 38 IB: 310-319.
39. Li XL, Cooley BC, Fowler JD, Gould JS. Intravascular heparin protects muscle flaps from ischemia/reperfusion injury. Microsurgery. 1995; 16: 90-93.
40. Braam MJ, Cooley BC, Gould JS. Topical heparin enhances patency in a rat model of arterial thrombosis. Annals Plast Surg. 1995; 34: 148-153.
41. Li XL, Cooley BC. Effect of anticoagulation and inhibition of platelet aggregation on arterial versus venous microvascular thrombosis. Annals Plast Surg. 1995; 35: 165-170.
42. Ozbek MR, Brown DM, Deune EG, et al. Topical tissue factor pathway inhibitor improves free-flap survival in a model simulating free-flap errors. J Reconstr Microsurg. 1995; 11: 185-188. doi: 10.1055/s-2007-1006529
43. Cooley BC, Gould JS. Investigation in the use of topical solutions for management or prevention of thrombosis in traumatized vessels. Internatl Angiology. 1995; 14: 297-302.
44. Jones R, Braam MJ, Cooley BC. Arterial thrombosis enhanced by an acute phase response. Annals Plast Surg. 1996; 36: 14-17.
45. Lantieri LA, Ozbek MR, Deune EG, et al. Prevention of microvascular thrombosis by topical application of tissue factor pathway inhibitor. Plast Reconstr Surg. 1996; 97: 587-594.
46. Khouri RK, Koudsi B, Cooley BC, Deune EG, Gilula LA, Reddi AH. Induction of normal bone by osteogenin, a bone morphogenetic protein: Specificity of the responding tissue and requirement for stem cell proliferation. Plast Reconstr Surg. 1996; 98: 103-109.
47. Isogai I, Cooley BC, Kamiishi H. Clinical outcome of digital replantation using the fibrin glue-assisted microvascular anastomosis technique. J Hand Surg (Brit & Europ Issue). 1996; 21: 573-575.
48. Cooley BC. Heat-induced tissue fusion in microvascular anastomosis. Microsurgery. 1996; 17: 198-208.
49. Hupkens P, Cooley BC. Comparison of arterial and venous patency in a model of subendothelium-stimulated thrombosis. Microsurgery. 1996; 17: 226-229.
50. Cooley BC. The history of vein grafting. Microsurgery. 1998; 18: 234-236.
51. Khouri RK, Cooley BC, Kunselman AR, et al. A prospective study of microvascular free flap surgery and outcome. Plast Reconstr Surg. 1998; 102: 711-721.
52. Cooley BC, Daley RA. Free flap transplantation in mice. Microsurgery. 1998; 18: 320-323.
53. Cooley BC, Daley RA. Murine microvascular anastomosis model of thrombosis. Thrombosis Res. 1999; 96: 157-159. doi: http://dx.doi.org/10.1016/S0049-3848(99)00093-6
54. Fowler JD, Li XL, Cooley BC. Brief ex vivo perfusion with heparinized and/or citrated whole blood enhances tolerance of free muscle flaps to prolonged ischemia. Microsurgery. 1999; 19: 135-140.
1. 55. Tsai JC, Liu L, Cooley BC, Dichiara MR, Topper JN, Aird WC. The Egr-1 promoter contains information for constitutive and inducible expression in transgenic mice. FASEB J. 2000; 14: 1870-1872. doi: 10.1096/fj.99-1072fje
56. Khouri RK, Sherman R, Buncke HJ, et al. A Phase II trial of intraluminal irrigation with recombinant human tissue factor pathway inhibitor to prevent thrombosis in free flap surgery. Plast Reconstr Surg. 2001; 107: 408-415.
57. Cooley BC, Bergtrom G. Multiple combinations of alternatively spliced exons in rat tropomyosin- gene mRNA: evidence for 20 new isoforms in adult tissues and cultured cells. Arch Biochem Biophys. 2001; 390: 71-77. doi: 10.1006/abbi.2001.2347
58. Weiler H, Lindner V, Kerlin B, et al. Characterization of a mouse model for thrombomodulin deficiency. Arterioscler Thromb Vasc Biol. 2001; 21: 1531-1537. doi: 10.1161/hq0901.094496
59. Hsu PA, Cooley BC. Effect of exercise on microsurgical hand tremor. Microsurgery. 2003; 23: 323-327. doi: 10.1002/micr.10156
60. Datta YH, Wu FC, Dumas PC, et al. Characterization and genetic mapping of the bleeding disorder in the fawn-hooded hypertensive rat. Thrombosis and Hemostasis. 2003; 89: 1031-1042.
61. Cooley BC. Murine model of neointimal formation and stenosis in vein grafts. Arterioscler Thromb Vasc Biol. 2004; 24: 1180-1185. doi: 10.1161/01.ATV.0000129330.19057.9f
62. Kerlin B, Cooley BC, Isermann BH, et al. Cause-effect relation between hyperfibrinogenemia and vascular disease. Blood. 2004; 103: 1728-1734. doi: http://dx.doi.org/10.1182/blood-2003-08-2886
63. Cooley BC, Chen C-Y, Friedman K, Datta YH. A prothrombotic phenotype in the Copenhagen rat strain. Thrombosis Res. 2005; 115: 153-157. doi: http://dx.doi.org/10.1016/j.thromres.2004.07.011
64. Cooley BC. A model of murine interpositional vein grafting. Microsurgery. 2005; 25: 209-212. doi: 10.1002/micr.20106
65. Cooley BC, Daley RA, Toth JM. Long-term BMP-2 induced bone formation in rat island and free flaps. Microsurgery. 2005; 25: 167-173. doi: 10.1002/micr.20092
66. Cooley BC, Szema L, Chen CY, Schwab JP, Schmeling G. A murine model of deep vein thrombosis: characterization and validation in transgenic mice. Thrombosis and Haemostasis. 2005; 94: 498-503. doi: http://dx.doi.org/10.1160/TH05-03-0170
67. Falati S, Patil S, Gross PL, et al. Platelet PECAM-1 inhibits thrombus formation in vivo. Blood. 2006; 107: 535-541. doi:
http://dx.doi.org/10.1182/blood-2005-04-1512
68. Shi Q, Wilcox DA, Fahs SA, et al. Factor VIII ectopically targeted to platelets is therapeutic in hemophilia A with high-titer inhibitory antibodies. J Clin Invest. 2006; 116: 1974-1982. doi: 10.1172/JCI28416.
69. Rao R, Bagaria V, Cooley BC. Posterolateral intertransverse lumbar fusion in a mouse model: surgical anatomy and operative technique. The Spine Journal. 2007; 7: 61-67. doi: http://dx.doi.org/10.1016/j.spinee.2006.03.004
70. Cooley BC, Chen CY, Schmeling G. Increased venous versus arterial thrombosis in the Factor V Leiden mouse. Thrombosis Res. 2007; 119: 747-751. doi: http://dx.doi.org/10.1016/j.thromres.2006.02.014
71. Kusada A, Isogai N, Cooley BC. Electric injury model of murine arterial thrombosis. Thrombosis Res. 2007; 121: 103-106. doi: http://dx.doi.org/10.1016/j.thromres.2007.03.005
72. Kerschen EJ, Fernandez JA, Cooley BC, et al. Endotoxemia and sepsis mortality reduction by non-anticoagulant activated protein C. J Exp Med. 2007; 204: 2439-2448. doi: 10.1084/jem.20070404
73. Cooley BC. Differential neointimal response in vein grafts and wire-injured arteries. Circ J. 2007; 71: 1649-1652. doi: http://dx.doi.org/10.1253/circj.71.1649
74. Maroney SA, Cooley BC, Sood R, Weiler H, Mast A. Combined tissue factor pathway inhibitor and thrombomodulin deficiency produces an augmented hypercoagulable state with tissue specific fibrin deposition. J Thromb Haemost. 2008; 6: 111-117. doi: 10.1111/j.1538-7836.2007.02817.x
75. Rao R, Bagaria V, Gourab K, Haworth S, Shidham VB, Cooley BC. Autograft containment in posterolateral spine fusion. The Spine Journal. 2008; 8: 563-569. doi: 10.1111/j.1538-7836.2007.02817.x
76. Ionova IA, Vásquez-Vivar J, Whitsett J, et al. Deficient BH4 production via de novo and salvage pathways regulates NO responses to cytokines in adult cardiac myocytes. Am J Physiol Heart Circ Physiol. 2008; 295: H2178-H2187. doi: 10.1152/ajpheart.00748.2008.
77. Mosesson MW, Cooley BC, Hernandez I, Diorio JP, Weiler H. Thrombosis risk modification in transgenic mice containing the human fibrinogen thrombin-binding gamma’ chain sequence. J Thromb Haemost. 2009; 7: 102-110. doi: 10.1111/j.1538-7836.2008.03213.x
78. Rao R, Gourab K, Bagaria VB, Shidham VB, Metkar U, Cooley BC. The effect of platelet rich plasma and bone marrow on murine posterolateral lumbar spine arthrodesis with bone morphogenetic protein. J Bone Joint Surg [Am]. 2009; 91: 1199-1206. doi: 10.2106/JBJS.G.01375.
79. Pieper GM, Ionova IA, Cooley BC, et al. Sepiapterin decreases acute rejection and apoptosis in cardiac transplants independently of changes in nitric oxide and inducible nitric-oxide synthase dimerization. J Pharmacol Exp Ther. 2009; 329: 890-899. doi: 10.1124/jpet.108.148569.
80. Ionova IA, Vásquez-Vivar J, Cooley BC, et al. Cardiac myocyte-specific over-expression of human GTP cyclohydrolase I protects against acute cardiac allograft rejection. Am J Physiol - Heart Circ. 2010; 299: H88-H96. doi: 10.1152/ajpheart.00203.2010.
81. Pieper GM, Shah A, Harmann L, Cooley BC, Ionova IA, Migrino RQ. Speckle-tracking 2-dimensional strain echocardiography: A new noninvasive imaging tool to evaluate acute rejection in cardiac transplantation. J Heart Lung Transplant. 2010; 29: 1039-1046. doi: 10.1016/j.healun.2010.04.009.
82. Shi Q, Fahs SA, Kuether EL, Cooley BC, Weiler H, Montgomery RR. Targeting FVIII expression to endothelial cells regenerates a releasable pool of FVIII and restores hemostasis in a mouse model of hemophilia A. Blood. 2010; 116: 3049-3057. doi: 10.1182/blood-2010-03-272419.
83. Maroney SA, Cooley BC, Ferrel JP, Bonesho CE, Mast AE. Murine hematopoietic cell tissue factor pathway inhibitor limits thrombus growth. Arterioscler Thromb Vasc Biol. 2011; 31: 821-826. doi: 10.1161/ATVBAHA.110.220293.
84. Cooley BC. In vivo fluorescence imaging of large-vessel thrombosis in mice. Arterioscler Thromb Vasc Biol. 2011; 31: 1351-1356. doi: 10.1161/ATVBAHA.111.225334
85. Cooley BC. Murine models of thrombosis. Thrombos Res. 2012; 129 Suppl 2: S62-S64.
86. Maroney SA, Cooley BC, Ferrel JP, et al. Absence of hematopoietic tissue factor pathway inhibitor mitigates bleeding in mice with hemophilia. Proc Natl Acad Sci USA. 2012; 109: 3927-3931. doi: 10.1073/pnas.1119858109.
87. Khouri RK, Eisenmann-Klein M, Cardoso E, et al. Brava and autologous fat transfer is s safe and effective breast augmentation alternative: results of a six-year, eighty-one patients prospective multicenter study. Plast Reconstr Surg. 2012; 129: 1173-1187.
88. Yassai M, Cooley B, Gorski J. Developmental dynamics of post selection thymic iNKT. PLoS ONE. 2012; 7: e43509. doi: 10.1371/journal.pone.0043509.
89. Smith AS, Choi SH, Collins JNR, Travers RJ, Cooley BC, Morrissey JH. Inhibition of polyphosphate as a novel strategy for preventing thrombosis and inflammation. Blood. 2012; 120: 5103-5110. doi: 10.1182/blood-2012-07-444935
90. Kuether, EL, Fahs SA, Cooley BC, et al. Lentivirus-mediated platelet gene therapy of murine hemophilia A with pre-existing anti-FVIII immunity. J Thromb Haemostas. 2012; 10: 1570-1580. doi: 10.1111/j.1538-7836.2012.04791.x.
91. Cooley BC. Collagen-induced thrombosis in murine arteries and veins. Thrombos Res. 2013; 131: 49-54. doi: 10.1016/j.thromres.2012.09.019.
92. Cooley BC, Chen CY, Hess R, Schmeling G. Incomplete resolution of deep vein thrombosis under reduced flow conditions. Thrombos Res. 2013; 131: 55-58. doi: 10.1016/j.thromres.2012.01.004.
93. Zhi H, Rauova L, Hayes V, et al. Cooperative integrin/ITAM signaling in platelets enhances thrombus formation in vitro and in vivo. Blood. 2013; 121: 1858-1867. doi: 10.1182/blood-2012-07-443325.
94. McDonald RA, White KM, Wu J, et al. MiRNA-21 is dysregulated in response to vein grafting in mulitple models and genetic ablation in mice attenuates neointima formation. Eur Heart J. 2013; 34: 1636-1643. doi: 10.1093/eurheartj/eht105.
95. Cooley BC, Herrera AJ. Cross-modulatory effects of clopidogrel and heparin on platelet and fibrin incorporation in thrombosis. Blood Coag Fibrinolysis. 2013; 24: 593-598. doi: 10.1097/MBC.0b013e3283602a03.
96. Aleman MM, Walton BL, Byrnes JR, et al. Elevated prothrombin promotes venous, but not arterial, thrombosis in mice. Arterioscler Thromb Vasc Biol. 2013; 33: 1829-1836. doi: 10.1161/ATVBAHA.113.301607.
97. Shi G, Meister D, Daley RA, Cooley BC. Thrombodynamics of microvascular repairs: effects of antithrombotic therapy on platelets and fibrin. J Hand Surg [Am]. 2013; 38: 1784-1789. doi: 10.1016/j.jhsa.2013.05.033.
98. Cooley BC, Nevado J, Mellad J, et al. TGF-β signaling mediates endothelial to mesenchymal transition (EndMT) during vein graft remodeling. Science Translat Med. 2013; 6: 227ra34. doi: 10.1126/scitranslmed.3006927.
99. Lee N, Daley RA, Cooley BC: Rat posterior facial vein interpositional graft: a more relevant training model. Microsurgery. 2014; 34: 653-656. doi:10.1002/micr.22278.
100. Cooley BC. Experimental vein graft research: a critical appraisal of models. Heart Res Open J. 2015; 2(2): 53-59.

Michael A. McCulloch, MD

Assistant Professor
AI duPont Hospital for Children
Nemours Cardiac Center
1600 Rockland Road
Wilmington, DE 19803, USA

BiographyResearch InterestScientific ActivitiesPublications
Education


• (7/1991-6/1995 ) Wake Forest University, BS Winston-Salem, North Carolina
• (7/1995-7/1997 ) University of Texas Health Science Center in San Antonio Graduate School in Physiology, San Antonio, Texas
• (7/1997- 6/2001) University of Texas Health Science Center in San AntonioMD, San Antonio, Texas
• (7/2001-07/2004) Residency in Pediatrics University of Virginia Charlottesville, Virginia
• (8/2004-06/2008) Fellowship in Pediatric Cardiology University of Virginia
• (11/2008-12/2008) Clinical Visiting Fellow - Cardiac MRIs Mentored by Dr. Andy Powell and Dr. Tal Geva Childrens Hospital Boston


Post-Graduate Training


• (8/2005-5/2007 ) University of Virginia, MPHS Department of Public Health Sciences Charlottesville, Virginia


Current Employment


• (6/30/2008) Alfred I. duPont Hospital for Children
• Nemours Cardiac Center
• Medical Director, Pulmonary Hypertension Program
• Director, Cardiac MRI Program
• Member, Cardiac Transplantation/ Heart Failure Program
• Member, Cardiac Intensive Care Unit staff

His research interests include: pediatric cardiology.

PROFESSIONAL AND SCIENTIFIC SOCIETIES


• (1/2014-present) Ad hoc member of Medical Executive Committee of AI duPont Hospital for Children- Selected by Hospital Staff
• (3/2013-present) International Society of Heart and Lung Transplantation
• (5/2010-present) Society of Critical Care Medicine
• (2/2009-present) Society for Cardiovascular Magnetic Resonance
• (7/2008-present) American Heart Association
• (11/2006-2011) American Society of Echocardiography
• (8/2004-2010) American College of Cardiology
• (7/2001-2010) American Academy of Pediatrics


AWARDS


• (6/2010) Faculty Teacher of the Year Award Chosen by Pediatrics Residents of Thomas Jefferson University Alfred I duPont Hospital for Children
• (3/2010) Recognized for excellence in patient service by the Hospital Recognition and Rewards Committee at the Alfred I duPont Hospital for Children
• (5/2008) Edwin and Mary Kendig Research and Scholarship Award for outstanding achievements as a fellow in the Department of Pediatrics
• (5/2008) Andy Ford Award for excellence and innovation in the field of pediatric cardiovascular disease
• (6/2007) Fellow Teacher of the Year Award Chosen by Pediatric residents at University of Virginia
• (6/2004) Resident Teacher of the Year Award Chosen by Pediatric residents at University of Virginia

1. Davies RR, Haldeman S, McCulloch MA, Pizarro C. Creation of a Quantitative Score to Predict the Need for Mechanical Support in Children Awaiting Heart Transplant. Annals of Thoracic Surgery. 2014; 98(2): 675-684. doi: 10.1016/j.athoracsur.2014.04.087
2. Davies RR, McCulloch MA, Haldeman S, Pizarro C. Ventricular Assist Devices as a Bridge-to-Transplant Improve Early Post-Transplant Outcomes in Children. Journal of Heart and Lung Transplantation. 2014; 33(7): 704-712. doi: 10.1016/j.healun.2014.02.010
3. White SC, Seckeler MD, McCulloch MA, Buck ML, Hoke TR, Haizlip JA. Patients with Single Ventricle Anatomy May Respond Better to Octreotide Therapy for Chylothorax After Congenital Heart Surgery. Journal of Cardiac Surgery. 2014; 29: 259-264. doi: 10.1111/jocs.12263
4. Moore WS, McCulloch MA, Cies JJ, Davis DA. Levosimendan and its Relationship to Brain Natriuretic Peptide Levels in a Pediatric Heart Failure Patient. Critical Care Medicine. 2012; 40(12): U322-U323.
5. McCulloch MA, Lim DS. "What are the indications for the ECG in the pediatric emergency department?" . Critical Decisions in Electrocardiography. Brady WJ, Truwit JD. Blackwell Publishing. 2009. doi: 10.1002/9781444303551.ch2
6. McCulloch MA, Conaway MR, Haizlip JA, Buck MA, Bovbjerg VE, Hoke TR. Post Operative Chylothorax is Associated with Increased Incidence and Risk Profile for Central Venous Thromboses. Pediatric Cardiology. 2008; 29: 556-561.
7. Throckmorton AL, Untaroiu A, Allaire PE, et al. Numerical design and experimental hydraulic testing of an axial flow ventricular assist device for infants and children. ASAIO. 2007; 53(6): 754-761.
8. Woods WA, McCulloch MA. Care of the acutely ill pediatric heart transplant recipient. Pediatric Emergency Care. 2007; 23(10): 721-724.
9. Woods, WA, McCulloch MA. Cardiovascular emergencies in the pediatric patient. Emerg Med Clin N Am. 2005; 25(4): 1233-1249.
10. Throckmorton AL, Lim DS, McCulloch MA, et al. Computational Design and Experimental Performance Testing of an Axial Flow Pediatric VAD. ASAIO J. 2005; 51: 629-635.
11. McCulloch MA, Gutgesell HP, Saulsbury FT, Hellems M, Hammill WW, Lim DS. Limitations of echocardiographic periarterial brightness in the diagnosis of Kawasaki Disease. Journal of the American Society of Echocardiography. 2005; 18(7): 768-770. doi: 10.1016/j.echo.2004.12.017
12. Woods WA, Schutte DA, McCulloch MA. Care of children who have had surgery for congenital heart disease. American Journal of Emergency Medicine. 2003; 21(4): 318-327.

Anastasios (Tassos) Lymperopoulos, BPharm, MSc, PhD, FAHA

Assistant Professor of Pharmacology
Department of Pharmaceutical Sciences
College of Pharmacy
Nova Southeastern University
3200 S. University Dr
Health Professions Division (Terry) Bldg/Room 1338
Fort Lauderdale, FL 33328, USA

BiographyResearch InterestScientific ActivitiesPublications

Dr. Lymperopoulos’s career started by earning MSc in Medicinal Chemistry followed by PhD in Pharmacology, after graduating from the School of Pharmacy of the University of Patras, Greece. Its major turning point was in 2004, when he joined the lab of Dr. Walter Koch, a former postdoctoral fellow of Nobel laureate Professor Robert Lefkowitzs lab at Duke University. In addition, he has been a post-doctoral research fellow of the AHA for a total of three years in the past, and, in fact, his postdoctoral fellowship application with AHA in 2007 got an unusual 1-year extension based on its exceptionally high score. He has also been a finalist for the AHA-sponsored Melvin L. He holds two (provisional) research patents, and as a research grant reviewer for AHA. In addition, he is elected Fellow of the American Heart Association (FAHA) and its Council on Basic Cardiovascular Sciences (BCVS).

His research interests include: Molecular pharmacology, Physiology and Biology of G protein-coupled (heptahelical or seven transmembrane-spanning) receptors, Heart Failure, Cardiovascular Disease, Neurohormonal control of the Circulation, Adrenal Physiology and Pharmacology, Receptors for Adrenaline and Noradrenaline, Catecholamines, Receptors for Angiotensin II, Signal Transduction, Gene Therapy, Transgenic mice and rats, Aldosterone production regulation, Regulation of Adrenergic and Angiotensin Receptors, G protein-coupled receptor Kinases, Beta-Arrestins, Novel Biased G protein-Coupled Receptor Ligands.

AWARDS


• Lead-author publication in Nature Medicine
• 4-year Scientist Development Grant award by the American Heart Association (AHA)
Marcus Young Investigator Award in Basic Cardiovascular Sciences
• Cardiovascular Research Award of the Council on Basic Cardiovascular Sciences of the European Society of Cardiology (ESC)


HONORS


He is currently serving on the Editorial Boards of two peer-reviewed journals, as a regular peer-reviewer for several prestigious journals, including British Journal of Pharmacology, Circulation Research, and American Journal of Cardiology.

He has published in various prestigious scientific journals, in addition to Nature Medicine, such as: Circulation, JACC, PNAS, JBC, and Molecular Pharmacology.

Jun Feng, MD, PhD

Assistant Professor of Surgery
Manager of Cardiothoracic Surgery Lab
CVRC, Rhode Island Hospital
Alpert Medical School of Brown University
Coro West 5th Floor, Room 5.2351 Hoppin Street
Providence RI 02903, USA

BiographyResearch InterestScientific ActivitiesPublications

Dr. Feng is a graduate of Henan Medical University with special training in cardiovascular surgery in China. Dr. Feng then received his PhD in Physiology from University of Montreal, Canada and finished his postdoctoral training at Department of Surgery, School of Medicine, SUNY at Buffalo. Dr. Feng was then recruited as Research Assistant Professor of Surgery at School of Medicine, University of Miami, as Instructor of Surgery at BIDMC, Harvard Medical School. Dr. Feng is currently an Assistant Professor of Surgery at Warren Alpert Medical School of Brown University and at Department of Surgery, Cardiovascular Research Center, Rhode Island Hospital.
Dr. Feng serves as PI and co-investigator on grants funded by the Rhode Island Foundation and National Institute of Health. He has published more than 100 peer-review/editorial articles/book chapters and more than 110 abstracts as first authors and co-authors. He has served as editorial member and peer reviewer for a number of scientific journals in cardiovascular and surgical research.

His research interests include: patho-physiology of cardiopulmonary bypass, heart failure, myocardial infarction, myocardial engineering, peri-operative myocardial protection during cardiovascular surgery of adult and children.

MEMBERSHIP IN PROFESSIONAL SOCIETIES

• American Physiology Society (Regular Member: 1998-2000)
• International Society for Heart Research (Regular member: 1999-2002)
• American Heart Association (2000-Current)
• Calcium-activated potassium channels and microvascular function in animal and humans (PI) Bradykinin preconditioning of human microvasculature (PI)
• Myocardial stunning, and heart failure
• Coronary and peripheral microvascular reactivity after cardioplegia and cardiopulmonary bypass (NIH funded grant: Co-investigator)
• The molecular mechanisms of myocardial apoptosis following ischemia and reperfusion, especially during cardioplegic arrest
• Microvascular endothelial function following angiogenesis in diabetic and hypercholesterolemic pig models of chronic ischemia (NIH-Funded grant: Co-investigator)

ORIGINAL PUBLICATIONS IN PEER-REVIEWED JOURNALS

First Authors:

1. Feng J, Atanasiu R, Yamaguchi N, Lamontagne D, Chahine R, Nadeau R. Effects of ischemic preconditioning and hypothermia on ischemic contracture in the isolated rat heart. Medical Science Research. 1995; 23: 787-788.
2. Feng J, Wu GZ, Tang SB, Chahine R, Lamontagne D. Beneficial effects of iloprost cardioplegia in the ischemic arrest in isolated working rat heart. Prostaglandins Leukotrience Essential Fatty Acids. 1996; 62: 279-283. doi: http://dx.doi.org/10.1016/S0952-3278(96)90059-9
3. Feng J, Liu RY, Wu GZ, Tang SB. Pretreatment with tetramethylpyrazine increases the release of PGI2 and decreases TXA2 release in isolated rat heart. Planta Medicas. 1996; 62: 379-381. doi: 10.1055/s-2006-957915
4. Feng J, Liu RY, Wu GZ, Tang SB. Tetramethylpyrazine reduces cardiac-derived TXA2 release in isolated working rat heart. Medical Science Research. 1996; 24: 121-122.
5. Feng J, Liu RY, Wu GZ, Tang SB. PGE1 reduces cardiac-derived TXA2 in ischemic arrest in isolated working rat heart. Internal Journal Cardiology. 1996; 55: 265-270.
6. Feng J, Chahine R, Yamaguchi N, Lamontagne N, Nadeau R. Brief repetitive ischemia effects on norepinephrine release, functional recovery and arrhythmias in isolated perfused rat heart. Canadian Journal of Physiololgy and Pharmacology. 1996; 74: 1351-1358.
7. Feng J, Yamaguchi N, Chahine R, Lamontagne D, Nadeau R. Perfusate potassium: effect on ischemia-induced arrhythmias in preconditioning in the isolated rat heart. Medical Science Research. 1996; 24: 327-329.
8. Feng J, Yamaguchi N, Foucart S, Chahine R, Lamontagne D, Nadeau R. Transient ischemia inhibits nonexocytotic release of norepinephrine in the rat heart: Is bradykinin involved? Canadian Journal of Physiology and Pharmacology. 1997; 75: 665-670.
9. Feng J, Liu RY, Wu GZ, Tang SB. Effects of tetramethylpyrazine on the release of PGI2 and TXA2 in hypoxic rat heart. Molecular and Cellular Biochemistry. 1997; 167: 153-158.
10. Feng J, Wu GZ, Tang SB. The effects of tetramethylpyrazine on the incidence of arrhythmias and the release of PGI2 and TXA2 in the ischemic rat heart. Planta Medicas. 1999; 65: 268-270. doi: 10.1055/s-2006-960774
11. Feng J, Rosenkranz ER. Bradykinin pretreatment preconditions the heart by tyrosine kinase mediated pathways. Annals of Thoracic Surgery. 1999; 68: 1567-1572. doi: http://dx.doi.org/10.1016/S0003-4975(99)01041-3
12. Feng J, Li HL, Rosenkranz ER. Pinacidil pretreatment extends ischemia tolerance of neonatal rabbit hearts. Journal Surgical Research. 2000; 90: 131-137. doi: http://dx.doi.org/10.1006/jsre.2000.5865
13. Feng J, Li HL, Rosenkranz ER. Bradykinin protects the rabbit heart after cardioplegia via NO-dependent pathways. Annals of Thoracic Surgery. 2000; 70: 2119-2124. doi: http://dx.doi.org/10.1016/S0003-4975(00)02148-2
14. Feng J, Chahine R, Nadeau R. Influence of extracellular potassium on the antiarrhythmic effect of global preconditioning in isolated perfused rat heart. Molecular and Cellular Biochemistry. 2000; 214: 75-80.
15. Feng J, Schaus BJ, Fallavollita J, Lee TC, Canty JM. Preload induces troponin I degradation independently of myocardial ischemia. Circulation. 2001; 103: 2035-2037. doi: 10.1161/01.CIR.103.16.2035
16. Feng J, Li HL, Rosenkranz ER. Diazoxide protects the rabbit heart following cardioplegic ischemia. Molecular and Cellular Biochemistry. 2002; 233: 133-138.
17. Feng J, Li HL, Rosenkranz ER. KATP channel opener protects neonatal rabbit heart better than St. Thomas’ solution. Journal of Surgical Research. 2003; 109: 69-73. doi: http://dx.doi.org/10.1016/S0022-4804(02)00064-1
18. Feng J, Bianchi C, Li JY, Sellke FW. Improved profile of bad phosphorylation and caspase 3 activation after blood vs crystalloid cardioplegia. Annals of Thoracic Surgery. 2004; 77: 1384-1390. doi: http://dx.doi.org/10.1016/j.athoracsur.2003.09.053
19. Feng J, Bianchi C, Li JY, Sellke FW. Bradykinin preconditioning improves coronary microvascular reactivity during cardioplegia-reperfusion. Annals of Thoracic Surgery. 2005; 79: 911-916. doi: http://dx.doi.org/10.1016/j.athoracsur.2004.09.017
20. Feng J, Bianchi C, Sandmeyer JL, Li JY, Sellke FW. Bradykinin preconditioning improves the profile of cell survival proteins and limits apoptosis after cardioplegic arrest. Circulation. 2005; 112: I-190-195. doi: 10.1161/CIRCULATIONAHA.104.524454
21. Feng J, Bianchi C, Sandmeyer JL, Li JY, Sellke FW. Molecular indices of apoptosis after intermittent blood and crystalloid cardioplegic ischemia. Circulation. 2005; 112: I-184-189. doi: 10.1161/CIRCULATIONAHA.104.526160
22. Feng J, Sellke ME, Ramlawi B, et al. Bradykinin induces microvascular preconditioning via opening of calcium-activated potassium channels. Surgery. 2006; 140: 192-197. doi: http://dx.doi.org/10.1016/j.surg.2006.05.002
23. Feng J, Yano K, Monahan-Earley R, et al. Vascular bed-specific endothelium -dependent vasomomotor relaxation in the hagfish, myxine glutinosa. American Journal of Physiology (Regulatory, Integrative and Comparative). 2007; 293: R894-R900. doi: 10.1152/ajpregu.00080.2007
24. Feng J, Liu YH, Clements RT, et al. Calcium-activated potassium channels contribute to human coronary microvascular dysfunction after cardioplegia arrest. Circulation. 2008; 118 (Suppl I): S46-S51. doi: 10.1161/CIRCULATIONAHA.107.755827.
25. Feng J, Liu YH, Khabbaz KR, et al. Large conductance calcium-activated potassium channels contribute to the reduced myogenic tone of peripheral microvasculature after cardiopulmonary bypass. Journal of Surgical Research. 2009; 157: 123-128. doi: 10.1016/j.jss.2009.03.043.
26. Feng J, Liu YH, Khabbaz KR, et al. Endothelin-1 induced contractile responses of human coronary arterioles via endothelin-A receptors and PKC- signaling pathways . Surgery. 2010; 147: 798-804. doi: 10.1016/j.surg.2009.11.016.
27. Feng, J, Scott MD, Monica L, Sellke FW, Ferran CJ, Abid R. Endothelium-dependent coronary vasodilatation requires NADPH oxidase-derived ROS. Arterioscler Thromb Vasc Biol. 2010; 30: 1703-1710. doi: 10.1161/ATVBAHA.110.209726.
28. Feng J, Chu LM, Robich M, et al. Endothelin-1 induced contraction and signaling in the human skeletal muscle microcirculation. Circulation. 2010; 122: S150-S155. doi: 10.1161/CIRCULATIONAHA.109.928226.
29. Feng, J, Liu YH, Khabbaz K, et al. Decreased contractile response to endothelin-1 of peripheral microvasculature from diabetic patients. Surgery. 2011; 149: 247-252. doi: 10.1016/j.surg.2010.07.003.
30. Feng, J, Liu YH, Singh AK, et al. Impaired contractile response of human peripheral arterioles to thromboxane A-2 after cardiopulmonary bypass. Surgery. 2011; 150: 263-271. doi: 10.1016/j.surg.2011.06.004.
31. Feng, J, Liu YH, Chu LM, et al. Thromboxane induced contractile response of human coronary arterioles is diminished post-cardioplegic arrest. Annals of Thoracic Surgery. 2011; 92: 829-836. doi: 10.1016/j.athoracsur.2011.04.049.
32. Feng, J, Chu LM, Dobrilovic N, Liu YH, Singh AK, Sellke FW. Decreased coronary microvascular reactivity after cardioplegic arrest in patients with uncontrolled diabetes mellitus. Surgery. 2012; 152: 282-289. doi: 10.1016/j.surg.2012.04.009.
33. Feng, J, Liu YH, Chu LM, et al. Changes in microvascular reactivity after cardiopulmonary bypass in patients with poorly controlled versus controlled diabetes. Circulation. 2012; 126: S73-S80. doi: 10.1161/CIRCULATIONAHA.111.084590
34. Feng J, Liu YH, Dobrilovic N, et al. Altered apoptosis-related signaling after cardioplegic arrest in patients with uncontrolled type 2 diabetes . Circulation. 2013; 128: S144 -S151. doi: 10.1161/CIRCULATIONAHA.112.000332.
35. Feng J, Liu YH, Dobrilovic N, et al. Altered expression and activation of mitogen-activated protein kinases in diabetic heart during cardioplegic arrest and cardiopulmonary bypass. Surgery. 2013; 154: 436-443. doi: 10.1016/j.surg.2013.05.016.


Co-authors:

36. Chahine R, Feng J. Protective effects of taurine against reperfusion-induced arrhythmias in isolated ischemic rat heart. Arzneim Forch/Drug Res. 1998; 48: 360-364.
37. Thomas S, Fallavollita J, Lee TC, Feng J, Canty JM, Jr. Absence of troponin I degradation or altered sarcoplasmic reticulum uptake protein expression following reversible ischemia in swine. Circulation Research. 1999; 85: 446-456. doi: 10.1161/01.RES.85.5.446
38. Voisine P, Bianchi C, Ruel M, et al. Inhibition of the cardiac angiogenic response to exogenous vascular endothelial growth factor. Surgery. 2004; 136: 407-415. doi: http://dx.doi.org/10.1016/j.surg.2004.05.017
39. Khan TA, Bianchi C, Voisine P, et al. Reduction of myocardial reperfusion injury by aprotinin after regional ischemia and cardioplegic arrest. Journal of Thoracic and Cardiovascular Surgery. 2004; 128: 602-608. doi: http://dx.doi.org/10.1016/j.jtcvs.2004.02.037
40. Voisine P, Bianchi C, Khan TA, et al. Normalization of coronary microvascular reactivity and improvement in myocardial perfusion by surgical VEGF therapy combined with oral supplementation of L-arginine in a porcine model of endothelial dysfunction. Journal of Thoracic and Cardiovascular Surgery. 2005; 129: 1414-1420.
41. Khan TA, Bianchi C, Voisine P, Sandmeyer JL, Feng J, Sellke FW. Aprotinin inhibits protease-dependent platelet aggregation and thrombosis. Annals of Thoracic Surgery. 2005; 79: 1545-1550. doi: http://dx.doi.org/10.1016/j.athoracsur.2004.11.006
42. Khan TA, Bianchi C, Araujo E, et al. Aprotinin preserves coronary cellular junctions and reduces myocardial edema after regional ischemia and cardioplegic arrest. Circulation. 2005; 112: I-196-201. doi: 10.1161/CIRCULATIONAHA.104.526053
43. Voisine P, Li J, Bianchi C, et al. Effects of L-arginine on FGF-2-induced angiogenesis in a model of endothelial dysfunction. Circulation. 2005; 112: I-121-127. doi: 10.1161/CIRCULATIONAHA.104.526350
44. Nakai Y, Voisine P, Bianchi C, et al. Effects of L-arginine on the endogenous angiogenic response in a model of hypercholesterolemia. Surgery. 2005; 138: 291-298. doi: http://dx.doi.org/10.1016/j.surg.2005.06.013
45. Boodhwani M, Cohn WE, Feng J, et al. Safety and efficacy of novel gel for vascular occlusion in off-pump surgery. Annals of Thoracic Surgery. 2005; 80: 2333-2337. doi: http://dx.doi.org/10.1016/j.athoracsur.2005.05.031
46. Boodhwani M, Nakai Y, Mieno S, et al. Hypercholesterolemia impairs the myocardial angiogenic response in a swine model of chronic ischemia: Role of endostatin and oxidative stress. Annals of Thoracic Surgery. 2006; 81: 634-641. doi: http://dx.doi.org/10.1016/j.athoracsur.2005.07.090
47. Boodhwani M, Nakai Y, Voisine P, et al. High dose atorvastatin improves hypercholesterolemic coronary endothelial dysfunction without improving the angiogenic response. Circulation. 2006; 114: I402-I408. doi: 10.1161/CIRCULATIONAHA.105.000356
48. Boodhwani M, Feng J, Mieno S, et al. Effects of purification poloxamer 407 gel on vascular occlusion and the coronary endothelium. European Journal of Cardio-Thoracic Surgery. 2006; 29: 736-741. doi: 10.1016/j.ejcts.2006.02.024
49. Ramlawi B, Feng J, Mieno S, et al. Indices of apoptosis activation after blood cardioplegia and cardiopulmonary bypass. Circulation. 2006; 114 : I257-I263. doi: 10.1161/CIRCULATIONAHA.105.000828
50. Mieno S, Boodhwani M, Ramlawi B, et al. Human coronary microvascular effects of cardioplegia induced stromal derived factor-1. Annals of Thoracic Surgery. 2006; 82: 657-663. doi: http://dx.doi.org/10.1016/j.athoracsur.2006.03.044
51. Boodhwani M, Mieno S, Voisine P, et al. High-dose atorvastatin is associated with impaired myocardial angiogenesis in response to vascular endothelial growth factor in hypercholesterolemic swine. Journal of Thoracic Cardiovascular Surgery. 2006; 132: 1299-1306. doi: http://dx.doi.org/10.1016/j.jtcvs.2006.05.060< br> 52. Ramlawi B, Rudolph JL, Khabbaz K, et al. C Reactive protein and inflammatory response associated to neurocognitive decline following cardiac surgery. Surgery. 2006; 140: 221-226. doi: http://dx.doi.org/10.1016/j.surg.2006.03.007
53. Ramlawi B, Scott JR, Feng J, et al. Inhaled carbon monoxide prevents graft-induced intimal hyperplasia in swine . Journal of Surgical Research. 2007; 138: 121-127. doi: http://dx.doi.org/10.1016/j.jss.2006.08.031
54. Khan T, Bianchi C, Ruel M, Feng J, Sellke FW. Differential effects on the mesentery microcirculatory response to vasopressin and phenylephrine after cardiopulmonary bypass. Journal of Thoracic Cardiovascular Surgery. 2007; 133: 682-688. doi: http://dx.doi.org/10.1016/j.jtcvs.2006.09.025
55. Sodha NR, Feng J, Clements RT, et al. Protein Kinase Ca modulates microvascular reactivity in the human coronary and skeletal microcirculation. Surgery. 2007; 142: 243-252. doi: http://dx.doi.org/10.1016/j.surg.2007.03.010
56. Boodhwani M, Mieno S, Sodha NR et al. Functional, cellular, and molecular characterization of the angiogenic response to chronic myocardial ischemia in diabetes. Circulation. 2007; 116: I31-137. doi: 10.1161/CIRCULATIONAHA.106.680157
57. Sodha NR, Boodhwani M, Clements RT, et al. Coronary microvascualr dysfunction in the setting of chronic ischemia is independent of arginase activity. Microvascular Research. 2007; 75: 238-246. doi: 10.1016/j.mvr.2007.06.008
58. Clements RT, Sodha NR, Feng J, et al. Cardioplegia and cardiopulmonary bypass induces phosphorylation and myofilament localization of heat shock protein 27 and αB-crystallin in human myocardium. Journal of Thoracic and Cardiovascular Surgery. 2007; 134: 1461-1470. doi: http://dx.doi.org/10.1016/j.jtcvs.2007.06.026
59. Boodhwani M, Sodha NR, Xu SH, et al. Insulin treatment enhances the myocardial angiogenic response in diabetes. Jounal of Thoracic and Cardiovascular Surgery. 2007; 134: 1453-1460. doi: http://dx.doi.org/10.1016/j.jtcvs.2007.08.025
60. Sodha NR, Boodhwani M, Ramlawi B, et al. Atorvastatin increases myocardial indices of oxidative stress in a porcine model of hypercholesterolemia and chronic ischemia. Journal of Cardiac Surgery. 2008; 23: 312-320. doi: 10.1111/j.1540-8191.2008.00600.x.
61. Khabbaz KR, Feng J, Boodhwani M, Clements RT, Bianchi C, Sellke FW. Non-ischemic myocardial acidosis adversely affects microvascular and myocardial function and triggers apoptosis during cardioplegia. Journal of Thoracic Cardiovascular Surgery. 2008; 135: 139-146.
62. Boodhwani M, Mieno S, Feng J, et al. Atorvastatin impairs the myocardial angiogenic response to chronic ischemia in normocholesterolemic swine. Journal of Thoracic and Cardiovascular Surgery. 2008; 135: 117-122. doi: 10.1016/j.jtcvs.2007.04.021.
63. Boodhwani M, Voisine P, Ruel M, et al. Comparison of vascular endothelial growth factor and fibroblast growth factor-2 in swine model of endothelial dysfunction. European Journal of Thoracic and Cardiovascular Surgery. 2008; 33: 645-650. doi: 10.1016/j.ejcts.2007.12.016.
64. Sodha NR, Clements RT, Feng J, et al. The effects of therapeutic sulfide on myocardial apoptosis in response to ischemia-reperfusion injury. European Journal of Thoracic Cardiovascular Surgery. 2008; 33: 906-913. doi: 10.1016/j.ejcts.2008.01.047.
65. Liu YH, Sellke EW, Feng J, et al. Calcium-activated potassium channels contribute to human skeletal muscle microvascular endothelial dysfunction related to cardiopulmonary bypass. Surgery. 2008; 144: 239-244. doi: 10.1016/j.surg.2008.03.032.
66. Clements RT, Smejka G, Sodha NR , et al. Pilot proteomic profile of differentially regulated proteins in right atrial appendage before and after cardiac surgery using cardioplegia and cardiopulmonary bypass. Circulation. 2008; 118: S24-S31. doi: 10.1161/CIRCULATIONAHA.107.792747.
67. Clements RT, Sodha NR, Feng J, et al. Impaired coronary vasodilation correlates with enhanced smooth muscle MLC phosphorylation in Diabetes. Microcirculation. 2009; 16: 193-206. doi: 10.1080/10739680802461950.
68. Sodha NR, Clements R, Feng J, et al. Hydrogen sulfide therapy attenuates the inflammatory response in a porcine model of myocardial ischemia/reperfusion injury. Journal of Thoracic and Cardiovascular Surgery. 2009; 138: 977-984. doi: 10.1016/j.jtcvs.2008.08.074.
69. Osipov RM, Bianchi C, Feng J, et al. Effect of hypercholesterolemia on myocardial necrosis and apoptosis in the setting of ischemia reperfusion. Circulation. 2009; 120: S22-S30. doi: 10.1161/CIRCULATIONAHA.108.842724.
70. Osipov RM, Robich M, Feng J, et al. The effect of thrombin fragment (TP508) on myocardial ischemia reperfusion injury in hypercholesterolemic pigs. Journal of Applied Physiology. 2009; 106: 1993-2001. doi: 10.1152/japplphysiol.00071.2009.
71. Osipov RM, Bianchi C, Clements RT, et al. Thrombin fragment (TP508) decreases myocardial infarction and apoptosis after ischemia reperfusion injury. Annals of Thoracic Surgery. 2009; 87: 786-793. doi: 10.1016/j.athoracsur.2008.12.021.
72. Osipov RM, Robich MP, Feng J, et al. Effect of hydrogen sulfide in a porcine model of myocardial ischemia-reperfusion: comparison of different administration regimens and characterization of the cellular mechanisms of protection. Journal of Cardiovascular Pharmacology. 2009; 54: 287-297. doi: 10.1097/FJC.0b013e3181b2b72b.
73. Qiu L, Chuttani R, Zhang S, et al. Diagnostic imaging of esophageal epithelium with clinical endoscopic polarized scanning spectroscopy instrument. Conf Proc IEEE Eng Med Biol Soc. 2009; 2009: 1997-2000. doi: 10.1109/IEMBS.2009.5333427.
74. Robich MP, Araujo EG, Feng J, et al. Altered coronary microvascular serotonin receptor expression after cardiac surgery. Journal of Thoracic and Cardiovascular Surgery. 2010; 139: 1033-1040. doi: 10.1016/j.jtcvs.2009.05.032.
75. Osipov RM, Robich MP, Feng J, et al. Effect of hydrogen sulfide on myocardial protection in the setting of cardioplegia and cardiopulmonary bypass. Interactive Cardiovascular and Thoracic Surgery. 2010; 10: 506-512. doi: 10.1510/icvts.2009.219535
76. Oyamada S, Bianchi C, Robich MP, et al. Effect of dimerized thrombin fragment TP508 on acute myocardial ischemia reperfusion injury in hypercholesterolemic swine. Journal of Pharmacology Experimental Therapeutics. 2010; 334: 449-459. doi: 10.1124/jpet.110.166348.
77. Chu LM, Osipov RM, Robich MP, Feng J, Sheller MR, Sellke FW. The Effect of thrombin fragment (TP508) on myocardial ischemia reperfusion injury in a model of type 1 diabetes. Circulation. 2010; 122: S162-S169. doi: 10.1161/CIRCULATIONAHA.109.928374.
78. Robich MP, Osipov R, Nezafat R, et al. Resveratrol improves myocardial perfusion in a swine model of hypercholesterolemia and chronic myocardial ischemia. Circulation. 2010; 122: S142-S149. doi: 10.1161/CIRCULATIONAHA.109.920132.
79. Robich MP, Osipov R, Chu L, et al. Temporal and spatial changes in collateral formation and function during chronic myocardial ischemia. Journal of American College Surgeon. 2010; 211: 470-480. doi: 10.1016/j.jamcollsurg.2010.06.009.
80. Chu LM, Osipov RM, Robich MP, et al. Is hyperglycemia bad for the heart during acute ischemia? Journal of Thoracic and Cardiovascular Surgery. 2010; 140: 1345-1352. doi: 10.1016/j.jtcvs.2010.05.009.
81. Robich MP, Matyal R, Chu LM, et al. Effects of neuropeptide Y on collateral development in a swine model of chronic myocardial ischemia. Journal of Molecular and Cellular Cardiology. 2010; 49: 1022-1030. doi: 10.1016/j.yjmcc.2010.08.022.
82. Robich MP, Chu LM, Feng J, et al. Effects of selective cyclooxygenase-2 and nonselective cyclooxygenase inhibition on ischemic myocardium. Journal of Thoracic and Cardiovascular Surgery. 2010; 140: 1143-1152. doi: 10.1016/j.jtcvs.2010.06.057.
83. Robich MP, Chu LM, Burgess TA, Feng J, Bianchi C, Sellke FW. Effects of selective cyclooxygenase-2 and nonselective cyclooxygenase inhibition on myocardial function and perfusion. Journal of Cardiovascular Pharmacology. 2011; 57: 122-130. doi: 10.1097/FJC.0b013e3182010a96.
84. Clements RT, Feng J, Cordeiro B, Bianchi C, Sellke FW. p38-MAPK-dependent small heat shock protein 27 (HSP27) and αB-crystallin (cryAB) phosphorylation in regulation of myocardial function following cardioplegic arrest. American Journal of Physiology. 2011; 300: H1669-H1677. doi: 10.1152/ajpheart.00272.2010.
85. Robich MP, Osipov RM, Chu LM, et al. Resveratrol modifies risk factors for coronary artery disease in swine with metabolic syndrome and myocardial ischemia. European Journal of Pharmacology. 2011; 664: 45-53. doi: 10.1016/j.ejphar.2011.04.059
86. Clements RT, Cordeiro B, Feng J, Bianchi C, Sellke FW. Rottlerin increases cardiac contractile performance and coronary perfusion following cold cardioplegic arrest in isolated hearts. Circulation. 2011; 124: S555-561. doi: 10.1161/CIRCULATIONAHA.110.012112.
87. Chu LM, Robich MP, Lassaletta AD, et al. Resveratrol supplementation abrogates pro-angiogenic effects of intramyocardial VEGF in a hypercholesterolemic swine model of chronic ischemia. Surgery. 2011; 150: 390-399. doi: 10.1016/j.surg.2011.06.009.
88. Chu LM, Robich MP, Lassaletta AD, et al. High-fat diet alters prostanoid balance and perfusion in ischemic myocardial of naproxen treated swine. Surgery. 2011; 150: 490-496. doi: 10.1016/j.surg.2011.07.022.
89. Chu LM, Robich MP, Bianchi C, et al. Effects of cyclooxygenase inhibition on cardiovascular function in a hypercholesterolemic swine model of chronic ischemia. American Journal of Physiology. 2012; 302: H479-488. doi: 10.1152/ajpheart.00146.2011.
90. Lassaletta AD, Chu LM, Robich MP, et al. Overfed Ossabaw swine with early stage metabolic syndrome have normal coronary collateral development in response to chronic ischemia. Basic Research in Cardiology. 2012; 107: 1-11. doi: 10.1007/s00395-012-0243-y.
91. Lassaletta AD, Chu LM, Elmadhun NY, et al. Cardioprotective effects of red wine and vodka in a model of endothelial dysfunction. Journal of Surgical Research 2012; 178: 586-592. doi: 10.1016/j.jss.2012.06.009
92. Robich MP, Chu LM, Burgess TA, et al. Resveratrol preserves myocardial function and perfusion in remote nonischemic myocardium in a swine model of metabolic syndrome. Journal of American College Surgeon. 2012; 215: 681-689. doi: 10.1016/j.jamcollsurg.2012.06.417.
93. Elmadhun NY, Lassaletta AD, Chu LM, Liu Y, Feng J, Sellke FW. Atorvastatin increases oxidative stress and modulates angiogenesis in Ossabaw swine with the metabolic syndrome. Journal of Thoracic and Cardiovascular Surgery. 2012; 144: 1486-1493. doi: 10.1016/j.jtcvs.2012.08.065.
94. Lassaletta AD, Elmadhun NY, Liu Y, et al. Ethanol promotes arteriogenesis and restores perfusion to chronically ischemic myocardium. Circulation. 2013; 128: S136-S143. doi: 10.1161/CIRCULATIONAHA.112.000207.
95. Shafique E, Choy WC, Liu Y, et al. Oxidative stress improves coronary endothelial function through activation of the pro-survival kinase AMPK. Aging. 2013; 5(7): 515-530.
96. Lassaletta AD, Elmadhun NY, Zanetti AV, et al. Rapamycin treatment of healthy pigs subjected to acute myocardial ischemia-reperfusion injury attenuates cardiac functions and increases myocardial necrosis. Annals of Thoracic Surgery. 2014; 97(3): 901-907. doi: 10.1016/j.athoracsur.2013.09.059.


OTHER PEER-REVIEWED PUBLICATIONS

1. Feng J, Sellke FW. Cardiomyocyte apoptosis following antegrade and retrograde cardioplegia (Invited Commentary). Annals of Thoracic Surgery. 2005; 80: 2234.
2. Feng J, Sellke FW. Pravastatin improves remodeling and cardiac function after myocardial infarction by an anti-inflammatory mechanism rather than by the induction of angiogenesis (Invited Commentary). Annals of Thoracic Surgery. 2006: 81: 2225-2226.
3. Feng J, Sellke FW. Enhanced angiogenesis with multimodal cell-based gene therapy (Invited Commentary). Annals of Thoracic Surgery. 2007; 83: 1119-1120.
4. Feng J, Sellke FW. Heat Shock proteins 27, 60, 70, 90 and 20S proteasome in on- versus off-pump coronary artery bypass graft patients. Annals of Thoracic Surgery. (Invited Commentary). 2008; 85: 87-88.
5. Feng J, Sellke FW. Tight glycemic control protects the myocardium and reduces inflammation in neonatal heart surgery (Invited Commentary). Annals of Thoracic Surgery. 2010; 90: 30.
6. Feng J. Endothelium-dependent vasoconstrictions in isolated vessel grafts: a novel mechanism of vasospasms? Annals of Thoracic Surgery. 2011; 92: 1307.
7. Feng J, Sellke FW. Transforming growth factor-alpha enhances stem cell- mediated post-ischemic myocardial protection (Invited Commentary). Annals of Thoracic Surgery. 2011; 92: 1726.
8. Feng J. Mammalian fetal Cardiac regeneration following myocardial infarction is associated with differential gene expression compared to the adult (Invited Commentary). Annals of Thoracic Surgery. 2014; 97(5): 1650-1651.

Pranav M. Patel, MD, FACC, FSCAI

Chief of Cardiology
Department of Medicine
University of California, Irvine
California, 92868-4080, USA

BiographyResearch InterestScientific ActivitiesPublications

Dr. Patel is currently the interim Chief of the Division of Cardiology at the University of California, Irvine. He has also been appointed as the Director of the Cardiac Catheterization Laboratory, Director of the CCU and the Clinical Associate Professor of Medicine. He is also served in the past as the Associate Director of the Cardiovascular Medicine and Interventional Cardiology fellowship programs at UC, Irvine.
Dr. Patel is Board Certified by the American Board of Internal Medicine in the fields of Internal Medicine (2003) and Cardiovascular Disease (2006) and Interventional Cardiology (2007). He received his medical degree from the St. Louis University, School of Medicine (1999); his degree was conferred with distinction in research.
Dr. Patel performed his internship and residency in Internal Medicine at Case Western Reserve University/ University Hospitals of Cleveland (1999-2002). From 2002-2006 he completed his General Cardiology and Interventional Cardiology fellowships at the Brown University, School of Medicine in Providence, Rhode Island. He then received further advanced training as a clinical and research at the Harvard’s Massachusetts General Hospital, before joining the faculty at UC, Irvine. He presented at national and international cardiology meetings. He has published articles in peer-reviewed medical journals and has authored multiple chapters in medical textbooks.

His clinical and research interests lie in the field of OCT/IVUS imaging, coronary artery disease, preventive medicine, interventional cardiology, peripheral vascular disease, medical education, clinical practice, quality care and outcomes.

• 1987-1990 Dean’s Academic Honor List.
• 1990 Rho Chi Pharmacy Honor Society Psi Chapter.
• 1997 American College of Physicians Award:Excellence in Physical Diagnosis.
• 1999 Doctor of Medicine with Distinction in Research Award.
• 2004 Brown Medical School Dean’s Award for Excellency in Teaching.
• 2010 Outstanding Role Model in Cardiology, University of California, Irvine.
• 2011 Outstanding Volunteer Teacher of the Year 2010-2011. Awarded by the Department of Family Medicine.
• 2012 Outstanding Role Model in Cardiology, University of California, Irvine.
• 2012 UC Irvine Internal Medicine Residency Faculty Development Committee Recognition: Rated top 20 percentage of all faculty members for teaching performance.

1. Taveira TH, Martin OJ, Petropoulos PN, Patel PM, Sharma SC, Wu WC. Effectiveness of interdisciplinary cardiovascular risk reduction clinic for patients with coronary artery disease or diabetes. Circulation. 2003; 107(19): e131, p4.
2. Patel PM, Wu WC, Cheng J, Martin OJ, Taveira TH, Sharma SC. Pattern of care for outpatients with coronary artery disease in a Veterans Administration hospital. Circulation. 2004; 109(20): e231, p184.
3. Martin OJ, Wu WC, Schleinitz MD, et al. Effectiveness of pharmacist-coordinated care on reducing multiple cardiovascular risk factors. Circulation. 2004; 109(7): e71, p203.
4. Patel PM, Wu WC. The Electrocardiogram in the Primary Care Office. Primary Care Clinics in Office Practice. 2005; 32(4): 901-930.
5. Sebastian CC, Wu WC, Shafer M, Choudhary G, Patel PM. Pneumopericardium and pneumothorax after permanent pacemaker implantation. Pacing and Clinical Electrophysiology. 2005; 28(5): 466-468.
6. Patel PM, Mamdani ST, Rosenfield K. Current challenges of renal artery stenosis: an illustrative case detailing difficult renal artery cannulation and angioplasty. Endovascular Today. 2007(6): 45-48.
7. Patel PM, Eisenberg J, Islam MA, Maree AO, Rosenfield KA. Percutaneous revascularization of persistant renal artery in-stent restenosis. Vascular Medicine. 2009; 14: 259-264. doi: 10.1177/1358863X08100386.
8. Islam MA, Rosenfield K, Maree AO, Patel PM, Jaff MR. Percutaneous revascularization of occluded renal arteries in the setting of acute renal failure. Vasc Med. 2009; 14 365-369. doi: 10.1177/1358863X09103200.
9. Salazar M, Kern MJ, Patel PM. Exact deployment of stents in ostial renal artery stenosis using the stent tail wire or Szabo technique. Catheter Cardiovasc Interv. 2009; 74(6): 946-50.
10. Mak GS, Kern MJ, Patel PM. Influence of obstructive sleep apnea and treatment with continuous positive airway pressure on fractional flow reserve measurements for coronary lesion assessment. Catheter Cardiovasc Interv. 2010; 75(2): 207-13. doi: 10.1002/ccd.22207.
11. Islam AM, Patel P. Preventing serious sequelae after an acute coronary syndrome: the consequences of thrombosis versus bleeding with antiplatelet therapy. J Cardiovasc Pharmacol. 2010; 55(6): 585-594. doi: 10.1097/FJC.0b013e3181d9f81f.
12. Seto AH, Abu-Fadel MS, Sparling JM, et al. Real-Time ultrasound guidance facilitates femoral arterial access and reduces vascular complications: FAUST (Femoral Arterial Access with Ultrasound Trial). JACC Cardiovasc Interv. 2010; 3: 751-758. doi: 10.1016/j.jcin.2010.04.015.
13. Edris A, Patel PM, Kern MJ. Early recognition of catheter-induced left main coronary artery vasospasm: Implications for revascularization. Catheter Cardiovasc Interv. 2010; 76; 304-307. doi: 10.1002/ccd.22462.
14. Siddiqi N, Seto A, Patel PM. Transcatheter closure of a mechanical perivalvular leak using real-time three-dimensional transesophageal echocardiography guidance. Catheter Cardiovasc Interv. 2011; 78(2): 333-5. doi: 10.1002/ccd.23162.
15. Edris A, Patel PM, Krishnam MS, Sengupta PP. Intramyocardial Hemorrhage after Percutanous Coronary Intervention. Echocardiography. doi: 10.1111/j.1540-8175.2011.01546.x.
16. Siddiqi N, Kern, MJ, Patel PM. Asymmetric Focal Pericardial Thickening Causing Physiologically Significant Constrictive Pericarditis. Catheter Cardiovasc Interv. 2012; 79: 809–811. doi: 10.1002/ccd.23079.
17. Zynda TK, Thompson CD, Hoang KC, et al. Disparity between angiographic coronary lesion complexity and lipid core plaques assessed by near infrared spectroscopy. Catheter Cardiovasc Interv. 2012; doi: 10.1002/ccd.24470.
18. Patel PM, Kern MJ. Moving Renal Embolic Protection Forward. Catheter Cardiovasc Interv. 2012; 79: 437–438. doi: 10.1002/ccd.24313.
19. Patel PM, Chen Z. When the doctor needs an engineer to be the matchmaker. EuroIntervention. 2012; 8: 19-23. doi: 10.4244/EIJV8I1A3.
20. PM Patel and MJ Kern. Mastering Transradial Techniques: Essential Skills for Complex Endovascular Peripheral Artery Intervention. Catheterization and Cardiovascular Interventions. 2012; 79: 1199–1200. doi: 10.1002/ccd.24456.
21. PM Patel and MJ Kern. Transradial Cardiac Catheterization: The Unfreeze-Change Theory. Catheterization and Cardiovascular Interventions. 2012; 80: 258–259. doi: 10.1002/ccd.24530.
22. MoharDS, Kim JK, Patel PM. Unique Morphological Variations of Transient Midventricular Syndrome: A Case Series-Review. Echocardiography. 2012; 29(9): 1132-1138. doi: 10.1111/j.1540-8175.2012.01779.x.
23. Patel PM, Kem MJ. Intravascular imaging: when two images are better than one. Catheter Cardiovassc Interv. 2013; 81(3): 508-9. doi: 10.1002/ccd.24819.
24. Dhoot J, Tariq S, Erande A, Amin A, Patel P, Malik S. Effect of morbid obesity on in-hospital mortality and coronary revascularization outcomes after acute myocardial infarction in the United States. Am J cardiol. 2013; 111(8): 1104-10. doi: 10.1016/j.amjcard.2012.12.033.
25. Li J, Ma T, Jing J, et al. Miniature optical coherence tomography-ultrasound probe for automatically co-registered three-dimensional intracoronary imaging with real-time display. J Biomed Opt. 18(10): 100502. doi: 10.1117/1.JBO.18.10.100502.
26. Yin Z, Li X, Jing J, et al. Novel miniature optical coherence tomography (OCT) – ultrasound (US) probe and integrated imaging system. Journal of Biomedical Optics. 2011; 16(6). doi: 10.1117/1.3589097.
27. Xiang L, Jiawen L, Joe J, et al. Integrated IVUS-OCT catheter for in vivo intravascular imaging. Institute of Electrical and Electronics Engineers. International Ultrasonic Symposium Proceedings. 2012; 1564-1567.
28. Li X, Li J, Jing J, et al. Integrated IVUS-OCT Imaging for Atherosclerotic Palgue Characterization. Selected Topics in Quantum Electronics. IEEE Journal. 2013; 20(2): 7100-7108..
29. Li J, Ma T, Jing J, et al. Miniature optical coherence tomography-ultrasound probe for automatically coregistered three-dimensional intracoronary imaging with real-time display. J Biomed Opt 2013; 18(10): 100502. doi: 10.1117/1.JBO.18.10.100502.
30. Li J, Li X, Mohar D, et al. Integrated IVUS-OCT for Real-Time Imaging of Coronary Atheroscierosis. J Am Coll Cardiol Img. 2014; 7(1): 101-103. doi: 10.1016/j.jcmg.2013.07.012.
31.Patel PM. Patient Quality Measures: The Necessary Paradigm Shifts in Medicine. Heart Res Open J. 2014; 1(1): e1-e2. doi: 10.17140/HROJ-1-e001

Majid Kalani, MD, PhD

Consultant Interventional Cardiologist
Department of Cardiology
Danderyd University Hospital and Karolinska Institute
Stockholm, Sweden

BiographyResearch InterestScientific ActivitiesPublications

Dr. Kalani is Senior Consultant Interventional Cardiologist at Danderyd University Hospital in Stockholm, Sweden, and Director of Cardiac Cath Lab at Ygia Polyclinic in Cyprus. Dr Kalani completed his PhD in the field of Cardiovascular Medicine and Diabetes Microangiopathy, and currently he is Senior Researcher at Karolinska Institute in Stockholm leading several research projects in the field of diabetes macro- and microangiopathy, and myocardial perfusion in interventional cardiology.

His interests include: Interventional cardiology, Permanent pacemaker implantation, General cardiology, Cardiothoracic intensive care, Emergency medicine especially internal medicine at the ER.

BOARDS AND COMMITTEES

• Member of the Education Committee of the Swedish Society of Cardiology – August 2002 to 2005
• Member of the Swedish Society of Angiology – January 2003 to 2008

Original articles:

1. Kalani M, Brismar K, Fagrell B, Ostergren J, Jorneskog G. Transcutaneous oxygen tension and toe blood pressure as predictors for outcome of diabetic foot ulcers. Diabetes Care. 1999; 22: 147-151.
2. Kalani M, Jorneskog G, Naderi N, Lind F, Brismar K. Hyperbaric oxygen (HBO) therapy of diabetic foot ulcers – long term follow up. Journal of Diabetes and Its Complications. 2002; 16: 153-158.
3. Kalani M, Apelqvist J, Blomback M, et al. Effect of Dalteparin on Outcome of Chronic Foot Ulcers in Diabetic Patients with Peripheral Arterial Occlusive Disease. A prospective, randomized, double-blind, placebo-controlled study. Diabetes Care. 2003; 26: 2575-2580.
4. Jorneskog G, Kalani M, Kuhl J, et al. Early microvascular dysfunction in healthy normal-weight males with heredity for type 2 diabetes. Diabetes Care. 2005; 28(6): 1495-7.
5. Kalani M, Silveira A, Blomback M, et al. Beneficial effects of dalteparin on haemostatic function and local tissue oxygenation in patients with diabetes, severe vascular disease and foot ulcers. Thromb Res. 2007; 120(5): 653-61.
6. Settergren M, Pernow J, Brismar K, Jorneskog G, Kalani M. Endothelin-A receptor blockade improves nutritive skin capillary circulation in patients with type 2 diabetes and albuminuria. J Vasc Res. 2008; 45: 295-302. doi: 10.1159/000113601.
7. Kalani M, Pernow J, Bragd J, Jorneskog G. Improved peripheral perfusion during endothelin-A receptor blockade in patients with type 2 diabetes and critical limb ischemia. Diabetes Care. 2008;3 1(7): e56 doi: 10.2337/dc08-0409.
8. Kalani M. The importance of endothelin-1 for microvascular dysfunction in diabetes. Vascular Health and Risk Management. 2008: 4(5): 1061-1068.
9. Skeppholm M, Kallner A, Kalani M, Jorneskog G, Blomback M, Wallén NH. ADAMTS-13 and von Willebrand factor concentrations in patients with diabetes mellitus. Blood Coagulation & Fibrinolysis, Blood Coagul Fibrinolysis. 2009; 20(8): 619-26. doi: 10.1097/MBC.0b013e32832da183.
10. Settergren M, BOhm F, Rydén L, Pernow J, Kalani M. Lipid lowering versus pleiotropic effects of statins on skin microvascular function in patients with dysglycemia and coronary artery disease. J Intern Med. 2009; 266(5): 492-8. doi: 10.1111/j.1365-2796.2009.02128.x.
11. Papadogeorgos N, Bengtsson M, Kalani M. Selective endothelin A-receptor blockade attenuates coronary microvascular dysfunction after coronary stenting in patients with type 2 diabetes. Vasc Health Risk Manag. 2009; 5: 893-9.
12. Papadogeorgos NO, Bengtsson M, Kalani M . Severely impaired microvascular function in diabetic patients with acute coronary syndrome. Vasc Health Risk Manag. 2009; 5: 893-9.
13. Kafian S, Mobarrez F, Kalani M, Wallén H, Samad BA. Comparison of venous and arterial blood sampling for the assessment of platelet aggregation with whole blood impedance aggregometry. Scand J Clin Lab Invest. 2011; 71(8): 637-40. doi: 10.3109/00365513.2011.604731
14. Jarnert C, Kalani M, Rydén L, BOhm F. Strict glycaemic control improves skin microcirculation in patients with type 2 diabetes: A report from the Diabetes mellitus And Diastolic Dysfunction (DADD) study. Diab Vasc Dis Res. 2012;
15. Torffvit O, Kalani M, Apelqvist J, et al. Increased Urine IgM and IgG(2) Levels, Indicating Decreased Glomerular Size Selectivity, Are Not Affected by Dalteparin Therapy in Patients with Type 2 Diabetes. Biochem Res Int. 2012; 2012: 480529. doi: 10.1155/2012/480529.

Emilia Mikolajewska, PhD

Physiotherapist and Senior Assistant
Rehabilitation Clinic
Military Clinical Hospital No. 10 and Polyclinic
Bydgoszcz, Poland

BiographyResearch InterestScientific ActivitiesPublications

Dr. Mikolajewska is a Physical therapist and scientist, author of 8 books, 40 book chapters, and 200 articles in journals covering topics of physiotherapy and rehabilitation, inventor in the area of rehabilitation, memeber of international research team Interdoctor. Selected postgraduate training and clinical practice covers NDT-Bobath, Cyriax, Kinesiology Taping methods, use of rehabilitation robots and biomedical engineering solutions in rehabilitation.

Her research interests include: eclectic therapy in physiotherapy and rehabilitation, including cardiological rehabilitation, co-operation within therapeutic multidisciplinary team, evidence Based Medicine in clinical practice, including physical therapy, biomedical engineering in rehabilitation, increasing of patients quality of life using: assistive devices, telemedicine, telerehabilitation, cybertherapy rehabilitative robotics, applications of IT, artificial intelligence and integrated systems in medicine.

RESEARCH EXPERIENCE

Jul 2013- Present:


Researcher on disorders of consciousness, rehabilitation and associated assistive technology

InteRDoCTor (International-Interdisciplinary Research for Disorders of Consciousnes in Toru?) research team .InteRDoCTor research team
Poland Torun, Kujawsko-Pomorskie
http://www.interdoctor.umk.pl/
Jun 2003- Present


Neurorehabilitation - adults and children

Military Clinical Hospital No. 10 with Polyclinic Rehabiltiation Clinic Posttraumatic Paraplegia Ward
Poland Bydgoszcz
Eclectic therapy, neurorehabilitation of adult patients and children, therapeutic multidisciplinary team, EBM, assistive devices, telerehabilitation, rehabilitative robotics, AI, integrated solutions

1. Mikolajewska E. The influence of the patient-physical therapist relationship on the outcomes of physical therapy: a narrative review of the literature. Medical Rehabilitation. 2011; 15 (3): 35-38.
2. Mikolajewska E. [Work-related musculoskeletal injuries in physiotherapists]. Med Pr. 2013; 64(5): 681-687.
3. Mikolajewska E. Associations between results of post-stroke NDT-Bobath rehabilitation in gait parameters, ADL and hand functions. Adv Clin Exp Med. 2013; 22(5): 731-738.
4. Mikolajewska E. Interdisciplinary therapy in Cornelia de Lange syndrome - review of the literature. Adv Clin Exp Med. 2013; 22(4): 571-577.
5. Mikolajewska E. The value of the NDT-Bobath method in post-stroke gait training. Adv Clin Exp Med. 2013; 22(2): 261-272.
6. Mikolajewska E. NDT-Bobath method in normalization of muscle tone in post-stroke patients. Adv Clin Exp Med. 2012; 21(4): 513-517.
7. Mikolajewska E, Mikolajewski D. Neuroprostheses for increasing disabled patients mobility and control. Adv Clin Exp Med. 2012; 21(2): 263-272.
8. Mikołajewska E, Mikołajewska D.Cardiac Telerehabilitation - Current State and Clinical Perspectives.Heart Res Open J. 2014; 1(1): 10-14. doi: 10.17140/HROJ-1-102

Seth J. Baum, MD, FACC, FACPM, FAHA, FNLA

Private practice of Cardiology, Boca Raton, FL.
Founder and Director of Clinical Development, VitalRemedyMD, Inc.
Founder, Foundation for Preventive and Integrative Medicine (FPIM)
7900 Glades Road, Suite 400 Boca Raton, FL 33434, USA

BiographyResearch InterestScientific ActivitiesPublications

Dr.Baum, a graduate of Columbia College of Physicians and Surgeons, completed training in Internal Medicine, Cardiology, Interventional Cardiology, and Electrophysiology. He has directed the Cardiac Catheterization laboratories at both Boca Raton and North Ridge hospitals, where he also founded the Electrophysiology laboratories. Dr. Baum has worked extensively in Integrative Cardiology, directing the Harvard affiliated Mind/Body Medicine Institute, Boca Raton division, lecturing nationally to physicians and the lay public, and teaching a graduate level course in Integrative Medicine at Florida Atlantic University. In 2002, Dr. Baum established The Foundation for Preventive and Integrative Medicine, a non-profit entity devoted to charity, education and research in preventive medicine.
In 2007, he formulated VitalOils1000, the first omega-3 oil to meet the AHA specifications of 1,000 mg of combined EPA+DHA in a single soft gel.
Dr. Baum is a fellow of the American College of Cardiology, the American Heart Association, the American College of Preventive Medicine, and the National Lipid Association. He is a Founding Physician/Scientist Member of the Society for Cardiovascular CT and is board certified in Cardiovascular CT. He lectures extensively in the fields of Lipidology, Preventive cardiology, and Integrative Cardiology. Deeply involved in the field of Omega-3 fatty acids, Dr. Baum served four years as treasurer of the International Society for the Study of Fatty Acids and Lipids (ISSFAL). In July of 2011, Dr. Baum was appointed Director of Women’s Preventive Cardiology at The Christine E. Lynn Women’s Health and Wellness Center, Boca Raton Regional Hospital. His responsibilities include both developing and overseeing this program. He is also the Treasurer of the American Society for Preventive Cardiology (ASPC). Annually, Dr. Baum chairs the ASPC’s Conference on CVD Prevention. Dr. Baum sits on the American Heart Association’s Council for Epidemiology and Prevention, the Interdisciplinary Council for Prevention, and the Prevention Science Committee representing the Epidemiology & Prevention (EPI) Council. He is also on the Board of Directors of the FH Foundation. He has written numerous peer reviewed papers as well as two books, The Total Guide to a Healthy Heart, and Age Strong, Live Long; Lessons from my Patients. In 2013 he was awarded the Cleveland Heart Lab’s annual “Heart Award” for his lifelong dedication to Preventive Medicine. On faculty at FAU Medical School and the University of Miami, Miller School of Medicine, Dr. Baum has a practice in Boca Raton, Florida that is devoted to Clinical Lipidology– he is board certified by the American Board of Clinical Lipidology - and Cardiovascular Prevention. Dr. Baum also runs the only LDL-Apheresis program in southeast Florida.

His research interests include: Lipidology, Preventive cardiology, and Integrative Cardiology.

PROFESSIONAL ASSOCIATIONS

Professional Colleges and Associations/Councils/Committees

1. Member of the American College of Physicians
2. Fellow of the American College of Cardiology
3. Board of American Heart Association, Boca Raton Chapter
4. National Lipid Association
5. Florida Lipid Foundation
6. American Society for Preventive Cardiology
7. Fellow of the American College of Preventive Medicine
8. Founding Physician/Society of Cardiovascular Computed Tomography
9. North American Society of Cardiac Imaging (NASCI)
10. American Heart Association Council on Cardiovascular Radiology and Intervention
11. American Heart Association Council on Cardiovascular Disease Epidemiology and Prevention
12. Fellow of the American Heart Association
13. Member, International Society for the Study of Fatty Acids and Lipids (ISSFAL)
14. ACPM Readers’ Digest Book Review Committee 2008
15. ACPM Lifestyle Medicine Initiative 2008
16. American Heart Association Council on Cardiovascular Disease Epidemiology and Prevention, Member/Liaison Publications Committee 2008-2016
17. Member Society for Atherosclerosis Imaging and Prevention
18. Peer Reviewer for Atherosclerosis
19. Peer Reviewer for the American Journal of Cardiology
20. Peer Reviewer for PLEFA
21. Fellow of the National Lipid Association
22. Interdisciplinary Council on Prevention, AHA 7/12-7/14
23. Member of the Prevention Science Committee representing the Epidemiology & Prevention (EPI) Council for the term dates, July 1, 2013 - June 30, 2015.
24. Member PAD and Women Working Group, AHA 11/13 forward


CONSULTING & CURRENT SPEAKERS’ BUREAUS:

• Kowa Pharmaceuticals     National Speaker and Consultant
• Aegerion Pharmaceuticals      National Speaker and Consultant
• Genzyme      Speaker
• Abbott Laboratories      National Speaker
• DiaDexus     National Speaker and Consultant
• LipoScience Laboratories     National Speaker, Education/Marketing
• Pri-Med Updates      National Speaker
• Solstas Lab Partners:     Consultant, Developed Cardiovascular Disease Profile Systems
• Cleveland Heart Labs     Consultant

ARTICLES AND BOOKS

1. Pucillo AL, Schecter AG, Moggio RA, Kay RH, Baum SJ, Herman MV. MR Imaging in the definition of Coronary Artery Anomalies. Journal of Assisted Tomography. 1990; 14(2): 171-174.
2. Rubin DA, Sorbera CA, Baum SJ, Mckallister AM, Niedelman R. Acute Reversible Diffuse Conduction System Disease Due to Lyme Disease. PACE. 1990; 13(1): 1367-1370.
3. Sorbera CA, Rubin DA, Baum SJ, Herman MV. Diagnosis and Treatment of Lyme Carditis Primary Cardiology. 1991; 17(7): 28-33.
4. Baum SJ. Prescription for a Healthy Heart. Healthy and Natural Magazine. 1999.
5. Baum SJ. Nutrients for a Healthy Heart. Alternative Medicine Magazine. 1999.
6. Baum SJ. The Total Guide to a Healthy Heart. Kensington Press. 1999;
7. Baum SJ, Kramer N, Crawford F. Health Personnel Antioxidant Study (HPAS): Effects of Antioxidant Supplementation of Functional Antioxidant Capacity. JANA winter. 2004; 7(1): 27-33
8. Baum SJ. Age Strong, Live Long; Lessons from my Patient. Desert Spring Press. 2005.
9. Baum SJ. Preventive Cardiology, Our Greatest Hope for Eradicating Heart Disease. JANA. 2007; 10(1).
10. Baum SJ. The Omega-3 Revolution. Healthy Aging Magazine. 2008
11. Baum SJ. Are you getting All the Right Tests? Radius Magazine. 2008.
12. Baum SJ. Spotting Heart Disease. Healthy Aging Magazine. 2008.
13. Baum SJ. CKD: It does not have to be the Harbinger of Cardiac Doom. Nephrology News and Issues. 2008.
14. Baum SJ. Weighing the Evidence. Healthy Aging Magazine. 2008.
15. Baum SJ. Awareness, the Key to Dissolving the Threat of Pulmonary Thromboembolism Medscape Public Health and Prevention. 3: 13,09
16. Baum SJ. Cardiac Risk Assessment, the Recipe for Personalized Prevention. Radius Magazine Winter. 2010.
17. Baum SJ. Controversies in Lipids. Lipid Spin Winter. 2010.
18. Baum SJ. Retinopathy Progression in Type 2 Diabetes. NEJM. 2010.
19. Baum SJ, Aidan H. Fatty Acids and Their Derivatives in CVD: Arachidonic, Eicosapentaenoic, and Docosahexaenoic Acids and their Byproducts, the Eicosanoids and Docosanoids. Curr. Cardiovasc. Risk Reports. 2012.
20. Baum SJ. Evidence-Based Medicine: Whats the Evidence? Clin. Cardiol. 2012; 35(5): 259–260.
21. Baum SJ. Fatty acids in cardiovascular health and disease: A comprehensive update. Journal of Clinical Lipidology. 2012; 6: 216-34. doi: 10.1016/j.jacl.2012.04.077.
22. Baum SJ. EPA and DHA: Distinct yet Essential n-3 fatty Acids. Journal of Clinical Lipidology. 2012; 6: 477-79 doi: 10.1016/j.jacl.2012.04.001.
23. Baum SJ. A Survey of Internists and Cardiologists: Are Discoveries in Fatty Acids Truly Being Translated into Clinical Practice? Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA). 2012 doi: 10.1016/j.plefa.2012.05.001.
24. Baum SJ. ANCHOR Trial Conclusions Regarding the Effects of Pure Eicosapentaenoic Acid on Low-Density Lipoprotein Cholesterol. Am J Cardiol. 2013; 111(3): 454-5 doi: 10.1016/j.amjcard.2012.11.035.
25. Baum SJ. The American Thinker: Divided We Fall. 2013.
26. Baum SJ. Familial Hypercholesterolemia: The Difficult to Manage Patient. 2013; http: //cardiometabolic.cardiosource.org/.
27. Baum SJ. Pitfalls of Population-based Preventive Medicine. JAMA. 2013; 310(20); 2202 doi: 10.1001/jama.2013.278919.
28. Baum SJ. From the Ivory Tower to the Trenches: A Practical Approach to the 2013 ACC/AHA Cholesterol and Risk Assessment Guidelines. JCL. 8(2): 231-233 doi: 10.1016/j.jacl.2013.12.010.

Wilbert S. Aronow, MD

Professor
Cardiology Division
New York Medical College
Valhalla, NY, USA

BiographyResearch InterestScientific ActivitiesPublications

Dr. Aronow is a Professor of Medicine at New York Medical College/Westchester Medical Center, Valhalla, NY, USA. Dr. Aronow received his MD from Harvard Medical School. He has edited 13 books and is author or co-author of 1,470 papers, 322 commentaries or Letters to the Editor, and 1028 abstracts and is presenter or co-presenter of 1,389 talks at meetings. Dr. Aronow is a Fellow of the ACC, the AHA, the ACP, the ACCP, the AGS (Founding Fellow of Western Section), and the GSA. He has been a Member of 119 editorial boards of medical journals, editor-in-chief of 1 journal, co-editor of 2 journals, deputy editor of 1 journal, executive editor of 3 journals, associate editor for 9 journals, and guest editor for 7 other medical journals. He has received each year from 2001-2015 an outstanding teacher and researcher award from the medical residents and from 2001-2015 from the cardiology fellows at Westchester Medical Center/New York Medical College. He has received awards from the Society of Geriatric Cardiology, the Gerontological Society of America, New York Medical College including the 2014 Chancellors Research Award, the F1000 Faculty Member of the Year Award for the Faculty of Cardiovascular Disorders in 2011, 2013, and 2014, the Walter Bleifeld Memorial Award for distinguished contributions to clinical research from the International Academy of Cardiology in July, 2010, and a Distinguished Fellowship Award from the International Academy of Cardiology in July, 2012. He has been a Member of 4 national guidelines committees including being a co-author of the 2010 AMDA guidelines for heart failure, co-chair and first author of the 2011 ACC/AHA expert consensus document on hypertension in the elderly, a co-author of the 2015 AHA/ACC/ASH scientific statement on treatment of hypertension in patients with coronary artery disease, and is currently a Member of the 2016 ACC/AHA/AAPAABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA guideline for the management of patients with hypertension. He was a Co-author of a 2015 position paper from the International Lipid Expert Forum. He was a Consultant to the American College of Physicians Information and Educational Resource (PIER) on the module of aortic stenosis. He is currently a member of the Board of Directors of the ASPC and a member of the ACCP Cardiovascular Medicine and Surgery Network Steering Committee.

His research interest include: Cardiovascular disease.

He is a Fellow of the American Geriatrics Society (Founding Fellow of Western Section), a Founding Fellow of the Society of Geriatric Cardiology, a Fellow of the Gerontological Society of America, a Fellow of the American College of Physicians, a Fellow of the American College of Cardiology, a Fellow of the American Heart Association, a Fellow of the American College of Chest Physicians, and a Fellow of the New York Cardiological Society. He is a member of the American Federation for Medical Research, a member of the American Medical Directors Association, and a member of the American Society for Clinical Pharmacology and Therapeutics.

He is author or co-author of 1,358 papers and 225 commentaries or letters to the editor and have edited 12 books.


RECENT PUBLICATION


1. Aronow WS. Treatment of cardiac hemochromatosis. Heart Res Open J. 2015; 2(3): e3-e5. doi: 10.17140/HROJ-2-e002

Abdelali Agouni, PhD, FHEA

Lecturer in Cardiovascular Biology
Faculty of Health and Medical Sciences
School of Biosciences & Medicine | Department of Biochemistry & Physiology
University of Surrey
The Dorothy Hodgkin Building, Office 2AY02
Guildford, GU2 7XH, England, UK

BiographyResearch InterestScientific ActivitiesPublications

Dr. Agouni started his academic career with medical studies in Algeria, and then he graduated in 2005 with an MSc (distinction) in Pharmacology from the University Louis Pasteur of Strasbourg (France). He then pursued his PhD studies in Clinical and Experimental Pharmacology at the prestigious laboratory of Neurovascular Integrated Biology (CNRS 6214-INSERM 771), University of Angers (France). After graduating with his PhD in 2008, he joined the School of Biological Sciences, University of Aberdeen (Scotland) as a post-doctoral Research Fellow. In October 2011, he joined the University of Surrey (England) as Lecturer in Cardiovascular Biology at the Faculty of Health and Medical Sciences. The University of Surrey is ranked 8th in the UK (Guardian League table 2014). Dr Agouni is a fellow of higher education academy (FHEA) since 2013. At Surrey, Dr Agouni has built up a research group to investigate the molecular mechanisms underpinning cardiovascular complications associated with metabolic disorders. Dr Agouni has published in the area of cardiovascular research over 20 publications, many in leading international peer-reviewed journals (e.g. Diabetes, Am. J. Respir. Crit. Care Med, Diabetologia, FASEB Journal, Am J Pathol, J Immunol, and J Pathol).

His research interests include: Endothelial dysfunction, obesity, diabetes, genetics of coronary artery disease, role of endoplasmic reticulum stress in diabetes and obesity, oxidative stress, role of phosphatases in insulin resistance and cardiovascular risk, angiogenesis.

ADMINISTRATIVE RESPONSIBILITIES & PROFESSIONAL MEMBERSHIPS

• Editorial Board member of “Archives of Physiology”
• Fellow of Higher Education Academy (FHEA) since November 2013.
• Organised and chaired a scientific session at the annual 24th meeting of the Group of Reflexion on Cardiovascular Research (GRRC), Tours, France, 25- 27 April 2007.
• Founding member of the Group of Reflexion on Cardiovascular Research (GRRC)’s youth club (2006)
• Founding member of Aberdeen School of Biological Sciences’ Post Doc society (2010)
• Elected member of the University of Angers (France) Scientific Council (2006 to 2008). The Scientific Council as part of the University Senate is responsible for the University’s research policy and budget.
• Full member of the Society of Physiology (France).
• Ordinary member of the Physiological Society (UK).
• Full member of the Biochemical Society (UK).
• Reviewer for international peer-reviewed journals (e.g. PloS ONE, BJP, Toxins, Circulation and Diabetes) and for national and international funding bodies (e.g. Medical Research Council, Swiss Science Foundation).

RESEARCH ARTICLES IN PEER-REVIEWED JOURNALS:

1. Grant L, Shearer K, Czopek A, et al. Myeloid-cell protein tyrosine phosphatase-1B deficiency protects against high-fat diet and lipopolysaccharide induced inflammation, hyperinsulinemia and endotoxemia through an IL-10 STAT3 dependent mechanism. Diabetes. 2013; 63(2): 456-470. doi: 10.2337/db13-0885.
2. Hoggard N, Agouni A, Mody N, and Delibegovic M. Serum Levels of Retinol Binding Protein 4 (RBP4) and Adipose Tissue Expression Levels of Protein Tyrosine Phosphatase 1B (PTP1B) are Increased in Obese Men Resident in North East of Scotland Without Any Changes in Endoplasmic Reticulum (ER) Stress Response Marker Genes. International Journal of General Medicine. 2012; 5: 403-11.
3. Alnabulsi A, Agouni A, Mitra S, et al. Cellular apoptosis susceptibility (chromosome segregation 1-like, CSE1L) gene is a key regulator of apoptosis, migration and invasion in colorectal cancer. Journal of Pathology. 2012; 4: 471-481. doi: 10.1002/path.4031.
4. Owen C, Czopek A, Agouni A, et al. Adipocyte-Specific Protein Tyrosine Phosphatase 1B Deletion Increases Lipogenesis, Adipocyte Cell Size and is a Minor Regulator of Glucose Homeostasis. PloS ONE. 2012; 7(2):e32700. doi: 10.1371/journal.pone.0032700.
5. Agouni A, Ducluzeau PH, Benameur T, et al. Microparticles from patients with metabolic syndrome induce vascular hypo-reactivity via Fas/Fas-Ligand pathway in mice. PloS ONE. 2011; 6(11): e27809. doi: 10.1371/journal.pone.0027809.
6. Agouni, A, Mody N, Owen C, et al. Liver-specific Deletion of Protein Tyrosine Phosphatase (PTP) 1B Improves Obesity- and Pharmacologically-Induced ER Stress and Reduces Oxidative and Nitrosative Stress. Biochemical Journal. 2011; 438(2):369-78. Impact factor 4.65 doi: 10.1042/BJ20110373.
7. Mody N, Agouni A, Mcilroy GD, Platt B and Delibegovic M. Susceptibility to Diet-Induced Obesity and Glucose Intolerance in APPSWE/PSEN1A246E Alzheimer Mice is Associated with Decreased Brain pAkt/PKB Phosphorylation and Increased Erk1/2 and S6 Phosphorylation and RBP4 levels. Diabetologia. 2011; 54(8):2143-51.
8. Banquet S, Delannoy E, Agouni A, et al. Role of Gi/o-Src kinase-PI3K/Akt pathway and caveolin-1 in β2-adrenoceptor coupling to endothelial NO Synthase in mouse pulmonary artery. Cellular signalling. 2011; 23(7):1136-43. doi: 10.1016/j.cellsig.2011.02.008.
9. Mastronardi ML, Mostefai HA, Soleti R, Agouni A, Martinez MC, Andriantsitohaina R. Microparticles from apoptotic monocytes enhance nitrosative stress in human endothelial cells. Fundamental & Clinical Pharmacology. 2011; 25(6):653-60. doi: 10.1111/j.1472-8206.2010.00898.x.
10. Agouni, A, Owen C, Czopek A, Mody N and Delibegović M. In vivo differential effects of fasting, re-feeding, insulin and insulin stimulation time course on insulin signalling pathway components in peripheral insulin-sensitive tissues. Biochemical and Biophysical Research Communications. 2010; 401(1): 104-111. doi: 10.1016/j.bbrc.2010.09.018.
11. Priou P, Gagnadoux F, Tesse A, et al. Endothelial nitric oxide dysfunction caused by circulating microparticles from patients with obstructive sleep apnea and severe nighttime hypoxia. American Journal of Pathology. 2010; 177(2): 974-83.
12. Agouni A, Lagrue-Lak-Hal AH, Mostefai HA, et al. Red wine polyphenols prevent metabolic and cardiovascular alterations associated with obesity in zucker fatty rats (Fa/Fa). PLoS ONE. 2009; 4(5):e5557. doi: 10.1371/journal.pone.0005557.
13. Agouni A, Lagrue-Lak-Hal AH, Ducluzeau PH, et al. Endothelial dysfunction caused by circulating microparticles from patients with metabolic syndrome. American Journal of Pathology. 2008; 173(4): 1210-1219. doi: 10.2353/ajpath.2008.080228.
14. Mostefai HA, Meziani F, Mastronardi ML, et al. Circulating microparticles from septic schock patients exert protective role on vascular function. American Journal of Respiratory and Critical Care Medicine 2008; 178(11):1148-55. doi: 10.1164/rccm.200712-1835OC.
15. Mostefai HA, Agouni A, Carusio N, et al. PI3-Kinase and Xanthine oxidase regulate NO and oxygen reactive species productions by apoptotic lymphocyte microparticles in endothelial cells.Both authors contributed equally to this work. Journal of Immunology. 2008; 180(7): 5028-5035.
16. Agouni A, Mostefai HA, Porro C, et al. Sonic hedgehog carried by microparticles corrects endothelial injury through nitric oxide release. FASEB Journal. 2007; 21(11): 2735-2741.
17. Agouni A, Sourbier C, Danilin S, et al. Parathyroid Hormone-Related Protein Induces Cell Survival through the phosphatidylinositol 3-kinase/Akt Pathway in Renal Cell Carcinoma: Evidence for a Critical Role for Integrin-Linked Kinase and Nuclear Factor kappa B. Carcinogenesis. 2007; 28(9): 1893-1901.
18. Sourbier C, Lindner V, Lang H, et al. The phosphatidylinositol 3-kinase/Akt pathway: A new target in human renal cell carcinoma therapy. Cancer Research. 2006; 66(10): 5130-5142.


REVIEW ARTICLES:

19. Agouni A, Andriantsitohaina R, Martinez MC. Microparticles as biomarkers of vascular dysfunction in Metabolic Syndrome and its individual components. Current Vascular Pharmacology. 2013;
20. Agouni A, Chalopin M, Martinez MC, Andriantsitohaina R. Protection by Red Wine Polyphenols against Metabolic and Cardiovascular Alterations Associated with Obesity: A Possible Link with Estrogen Alpha Receptor. Journal of Wine Research. 2011; 22(2): 151-157.

Zhonghua Sun, PhD

Associate Professor | Medical Imaging Discipline
Department of Imaging and Applied Physics
Curtin University
GPO Box U1987 Perth WA 6845
Australia

BiographyResearch InterestScientific ActivitiesPublications

Prof Sun is a Professor of medical imaging at Curtin University, Australia. He gained his M.B and PhD degrees in clinical medicine and medical imaging, respectively, from Harbin Medical University in China and University of Ulster in UK. He worked as a radiologist in the department of radiology at Peking Union Medical College Hospital for 9 years prior to taking up one-year medical fellowship during 1998-1999 in Japan. His research interests include diagnostic imaging, 3D medical image visualization and processing, hemodynamic analysis of cardiovascular disease and 3D printing in medicine. He has published 3 books, 9 book chapters, and over 190 refereed journal papers in medical/medical imaging journals. He is a Fellow of the Society of Cardiovascular Computed Tomography.

His research interests include diagnostic imaging, 3D medical image visualization and processing, and hemodynamic analysis of cardiovascular diseases.

PROFESSIONAL DEVELOPMENTS

• 2013- Member of European Atherosclerosis Society
• 2012- Overseas Associate member of IPEM (Institute of Physics in Engineering and Medicine)
• 2011-2013 Deputy member of Radiological Council of Western Australia
• 2007- Associate Member of Australian Institute of Radiography
• 2002-2004 Member of European Society of Radiology

1. Wong K, Tu J, Sun Z, Dissanyake D. Methods in research and development of biomedical devices. World Scientific Publishing. 2013;
2. Sun Z. Coronary computed tomography angiography in coronary artery disease: A systematic review of diagnostic accuracy, image quality, and radiation dose. Nova Science Publishers, Inc. 2013; 1-192.
3. Sun Z. 3D CT virtual intravascular endoscopy: clinical applications in cardiovascular disease. Nova Science Publishers, Inc. 2013; 1-170.


REFEREED JOURNALS (2002-PRESENT) (IMPACT FACTOR BASED ON ISI 2012)

1. Dong J, Sun Z, Inthavong K, Tu J. Fluid-structure interaction analysis of the left coronary artery with variable branch angulation. Comput Med Biomech Biomed Eng.
2. Yaakup N, Phuah H, Abdul Aziz Y, Zainal A, Sun Z, Ng KH. Dual-source computed tomography angiography in aortic stenosis: comparison with transthoracic echocardiography. J Med Imaging Health Inf. 2014;
3. Al-naani A, Khan L, Athlawy Y, Sun Z. Ochrobactrum anthropi induced retropharyngeal abscess with mediastinal extension complicating airway obstruction: A case report. J Med Radiart Sc . 2014;
4. Juan YH, Huang YC, Sun Z, et al. The evolution and investigation of native coronary arteries in patients after coronary stent implantations: a study by 320-detector CT angiography. Int J Cardiovasc Imaging. 2014;
5. Sun Z. ndovascular stents and stent grafts in the treatment of cardiovascular disease. J Biomed Nanotechnol. 2014;
6. Sun Z. Atherosclerosis and atheroma plaque rupture: normal anatomy of vasa vasorum and their role associated with atherosclerosis. Scientific World Journal . 2014; 2014: 285058: 6.
7. Sun Z. Atherosclerosis and atheroma plaque rupture: Imaging modalities in the visualization of vasa vasorum and atherosclerotic plaques. Scientific World Journal . 2014; 2014: 312764: 12.
8. Wan Ab, Naim N, Ganesan PB, et al. A perspective review on numerical simulation of hemodynamics in aortic dissection. Scientific World J . 2014; 2014: 652520, 12.
9. Sun Z. Chest computed radiography imaging parameters for nodule detection: a comparison of image quality and radiation dose. J Med Imaging Health Inf . 2014;
10. Sun Z, Al-naami A, Athlawy Y, Ali Khan L. Phytobezoars in the stomach and small bowel: CT findings. Curr Med Imaging Rev . 2014;
11. Ng C, Sun Z, Parry H, Burrage J. Local diagnostic reference levels for x-ray examinations in an Australian tertiary hospital. J Med Imaging Health Inf . 2014; 4: 297-302.
12. Ng EYK, Borovetz H, Soudah E, Sun Z. Numerical methods and applications in biomedical modelling. Comput Math Meth Med . 2013; 2013: 727830, 2 pages.
13. Sun Z. Coronary CT angiography in coronary artery disease: correlation between virtual intravascular endoscopic appearances and left bifurcation angulation and coronary plaques. Biomed Res Int . 2013; 2013: 732059, 14.
14. Lin C, Shih PW, Cheng KY, Sun Z. Frequent application of computed radiography imaging plate and image quality. J Med Imaging Health Inf.
15. Sabarudin A, Yusof MZ, Mohamed M, Sun Z. Radiation dose associated with cerebral CT angiography and CT perfusion: an experimental phantom study. Radiat Prot Dosim.
16. Sun Z. Cardiac imaging modalities in coronary artery disease. Clin Experiment Cardiol. 2013; S6: 1-4.
17. Sun Z, Sabarudin A. Coronary CT angiography: state of the art. World J Cardiol. 2013; 5: 442-443.
18. Sun Z. Coronary CT angiography: Beyond morphological stenosis analysis. World J Cardiol . 2013; 5: 444-452.
19. Sabarudin A, Sun Z. Coronary CT angiography: Beta-blocker administration protocol for prospectively ECG-triggered coronary CT angiography. World J Cardiol . 2013; 5: 453-458.
20. Sabarudin A, Sun Z. Coronary CT angiography: Radiation dose measurements in coronary CT angiography. World J Cardiol . 2013; 5: 459-464.
21. Sabarudin A, Sun Z. Coronary CT angiography: dose reduction strategies. World J Cardiol . 2013; 5: 465-472.
22. Sabarudin A, Sun Z. Coronary CT angiography: diagnostic value and clinical challenges. World J Cardiol . 2013; 5: 473-483.
23. Almoudi M, Sun Z. Myocardial perfusion imaging using 99mTc-MIBI SPECT: a cardiac phantom study. J Med Imaging Health Inf . 2013; 3: 480-486.
24. OHara S, Zelesco M, Sun Z. Cervical length for predicting preterm birth and a comparison of ultrasonic measurement techniques. Aus J Ultrasound Med . 2013; 16: 124-134.
25. Sun Z, Lin C. Computed tomography virtual intravascular endoscopy in the visualization of cardiovascular disease: imaging appearances and clinical value. J Radiol Diagn Imag .2013; 1:19-28.
26. Sun Z. Comment on: Diagnostic accuracy of 320-slice computed tomography angiography for detection of coronary artery stenosis: meta-analysis. Int J Cardiol. 2013; 168: 4895-4896.
27. Chaichana T, Sun Z, Jewkes J. Hemodynamic impacts of left coronary stenosis: A patient-specific analysis. Acta Bioeng Biomech . 2013; 15: 107-112.
28. Wan Ab Naim N, Ganesan PB, Sun Z, Osman K, Lim E. The impact of the number of tears in patient-specific Stanford type B aortic dissecting aneurysm: CFD simulation. J Mech Med Bio . 2013;
29. Sun Z, AbAziz A, Khairuddin Md Yusof A. Radiation-induced non-cancer risk in interventional cardiology procedures. J Biomed Biotechnol .2013; 2013: 976962, 12.
30. Sun Z. Tips for writing a case report for the novice author. J Med Radiat Sc . 2013; 60: 108-113.
31. Sun Z. A new platform for sharing research and teaching experience. J Case Reports Studies . 2013; 1: 1-2.
32. Sun Z. Cardiac imaging in the diagnosis of coronary artery disease: a comprehensive review of various imaging modalities. Curr Med Imaging Rev . 2013; 9: 167-169.
33. Sun Z, AbAziz A, Khairuddin Md Yusof A. Cardiac nuclear imaging: current status and future directions. Curr Med Imaging Rev . 2013; 9: 170-183.
34. Sun Z, Wang YL, Hsieh IC, Liu YC, Wen MS. Coronary CT angiography in the diagnosis of coronary artery disease. Curr Med Imaging Rev . 2013; 9: 184-193.
35. Nazri M, Bux SI, Kamalden TFT, Ng KH, Sun Z. Incidental detection of sinus mucosal abnormalities on CT and MRI imaging of the head. Sun Z. Cardiac CT imaging: current status and future directions. Quant Imaging Med Surg . 2013; 3: 82-88.
36. Sabarudin A, Khairuddin Md Yusof A, Sun Z. A survey exploring specialists and radiographers perceptions of the benefits and challenges in relation to prospectively ECG-triggered coronary CT angiography. J Med Imaging Health Inf. 2013; 3: 388-392.
37. Songib NA, Nazri M, Yaakup N, Nor HM, Sun Z. Multiphase renal CT in the evaluation of renal masses: Is the nephrographic phase necessary? Clin Imaging . 2013; 37: 1037-1042.
38. Sun Z, Ng C, Halkett G, Meng R, Jiwa M. An investigation of factors that influence general practitioners referral of computed tomography scans in patients with headache. Int J Clin Pract . 2013; 67: 682-690.
39. Lou YC, Sun Z, Chan T, Tsay PK, Hsieh IC, Chen CC, Wen MS, Wan YL. Significance of coronary calcification for prediction of coronary artery disease cardiac events based on 64-slice computed tomography coronary angiography. J Biomed Biotechnol. 2013; 2013: 472347: 9 pages.
40. Chaichana T, Sun Z, Jewkes J. Hemodynamic impacts of various types of stenosis in the left coronary artery bifurcations: A patient-specific analysis. Physics Medica . 2013; 29: 447-452.
41. Chaichana T, Sun Z, Jewkes. Haemodynamic analysis of the effect of different types of plaque at the left coronary artery. Comput Med Imaging Graph . 2013; 37: 197-206.
42. Sun Z, Almoudi M. Coronary CT angiography: technical developments, clinical applications and radiation dose. Interv Cardiol . 2013; 5: 89-100.
43. Sabarudin A, Khairuddin Md Yusof A, Tay MF, Ng KH, Sun Z. Dual-source CT coronary angiography: effectiveness of radiation dose reduction with lower tube voltage. Radiat Prot Dosim . 2013; 153: 441-447.
44. Sabarudin A, Sun Z, Ng KH. Coronary CT angiography with prospective ECG-triggering: A systematic review of image quality and radiation dose. Singapore Med J . 2013; 54: 15-23.
45. Sabarudin A, Sun Z. Coronary CT angiography with single-source and dual-source CT: Comparison of image quality and radiation dose between prospective ECG-triggered and retrospective ECG-gated protocols. Int J Cardiol . 2013; 168: 746-753.
46. Wu H, Sun Z, Cao D, Wu L, Zeng Q. Cardiovascular health status in Chinese urban adults: analysis of the Chinese Health Examination Database 2010. Int J Cardiol . 2013; 168: 760-764.
47. Sabarudin A, Sun Z, Ng KH. Radiation dose in coronary CT angiography associated with prospective ECG-triggered technique: comparisons with different CT generations. Radiat Prot Dosim . 2013; 154: 301-307.
48. Sun Z, Ng KH. Use of radiation in medicine in Asia Pacific region. Singapore Med J . 2012; 53: 784-788.
49. Almoudi M, Sun Z. A head-to-head comparison of coronary calcium score at computed tomography with myocardial perfusion imaging. J Geriatric Cardiol . 2012; 9: 349-354.
50. Almoudi M, Sun Z. Coronary artery calcium score: Re-evaluation of its predictive value for coronary arterydisease. World J Cardiol . 2012; 4 (10): 284-287.
51. Setiawati R, Dimpudus F, Sun Z. Chondroid lipoma of the right thigh: correlation of imaging findings and histopathology of an unusual benign lesion. Australasian Med J . 2012; 5: 355-358.
52. Sun Z. Evidence for contrast-enhanced ultrasound in fenestrated endovascular repair surveillance. J Endovasc Ther . 2012; 19: 656-660.
53. Wong KL, Sun Z, Tu J. Medical imaging and computer-aided flow analysis of a heart with an atrial septal defect. J Mech Med Bio . 2012; 12: 5.
54. Sun Z, Athlawy Y. Medical staff and patients knowledge about radiation exposure related to routine CT examinations. World Med Imaging Res . 2012; 0201: 1-9.
55. Wong KL, Sun Z, Worthley SG, Mazumdar J, Abbott D. Medical image diagnostics based on computer-aided flow analysis using magnetic resonance images. Comput Med Imaging Graph . 2012; 36: 527-541.
56. Sun Z. Cardiac CT imaging: current status and future directions. Quant Imaging Med Surg . 2012; 2: 98-105.
57. Chaichana T, Sun Z, Jewkes J. Investigation of the effect of bifurcation plaques on the left coronary artery in realistic patient models. Australas Phy Eng Sci Med . 2012; 35: 231-236.
58. Sun Z, Liu Y, Zhou D, Qi Y. Use of coronary CT angiography in the diagnosis of patients with suspected coronary artery disease: findings and clinical indications. J Geriatric Cardiol . 2012; 9: 115-122.
59. Wong KL, Thavornpattanappong P, Cheng S, Sun Z, Tu J. Effect of calcification on the mechanical stability of plaque based on a three-dimensional carotid bifurcation model. BMC Cardiovasc Disord . 2012; 12: 7.
60. Sun Z. Prospective ECG-gated coronary CT angiography in the diagnosis of coronary artery disease: An effective alternative to conventional imaging modalities. Cardiovasc Diag Treatment . 2012; 2: 28-37.
61. Sun Z, Al Ghamdi K, Baroum I. Multislice CT of the head and body routine scans: Are scanning protocols adjusted for paediatric patients? Biomed Imaging Intervent J . 2012; 1: e3.
62. Sun Z, Ng KH. Diagnostic value of coronary CT angiography with prospective ECG-gating in the diagnosis of coronary artery disease: A systematic review and meta-analysis. Int J Cardiovasc Imaging . 2012; 28: 2109-2119.
63. Sun Z, Choo, Ng KH. Coronary CT angiography: current status and continuing challenges. Br J Radiol . 2012; 85: 495-510.
64. Sun Z, Ng KH. Prospective versus retrospective ECG-gated multislice CT coronary angiography: A systematic review of radiation dose and image quality. Eur J Radiol . 2012; 81: e94-e100.
65. Chaichana T, Sun Z, Jewkes J. Impact of plaques in the left coronary artery on wall shear stress and pressure gradient in coronary side branches. Comput Med Biomech Biomed Eng . 2012;
66. Chaichana T, Sun Z, Jewkes J. Computational fluid dynamic analysis of the effect of plaques in the left coronary artery. Comput Math Meth Med . 2012; 2012: 504367.
67. Sun Z, Al-naami A, Ali Khan L. Perforated duodenal ulcer with anterior abdominal abscess: a case report. Australasian Med J . 2012; 5: 14-17.
68. Sun Z. Abdominal aortic aneurysm: Treatment options, image visualizations and follow-up procedures. J Geriatric Cardiol . 2012; 9: 49-60.
69. Sun Z, Lin C, Tyan Y, Ng KH. Optimization of chest radiographic imaging parameters: A comparison of image quality and entrance skin dose for six digital chest radiography systems. Clin Imaging . 2012; 36: 279-286.
70. Abdullah A, Sun Z, Pongnapang N, Ng KH. Comparison of computed tomography dose reporting software. Radiat Prot Dosim . 2012; 151: 153-157.
71. Sabarudin A, Sun Z, Ng KH. Radiation dose comparison associated with coronary CT angiography and invasive coronary angiography: An experimental study of the effect of dose-saving strategies. Radiat Prot Dosim . 2012; 150: 180-187.
72. Sun Z, Faridah Y, Ng KH. Coronary CT angiography: How should physicians use it widely and when do physicians request it appropriately? Eur J Radiol . 2012; 81: e684-e687.
73. Sabarudin A, Sun Z, Ng KH. A systematic review of radiation dose associated with different generations of multislice CT coronary angiography. J Med Imag Radiat Oncol . 2012; 56: 5-17.
74. Sun Z. Computed tomography angiography in the diagnosis of cardiovascular disease: 3D visualisations. Front Med . 2011; 5: 254-270.
75. Sun Z, Ng KH. Coronary CT angiography in coronary artery disease: A systematic review of the research directions. World J Cardiol . 2011; 3 (9): 303-310.
76. Sun Z, Cao Y, Li H. Multislice CT angiography in the diagnosis of coronary artery disease. J Geriatric Cardiol . 2011; 8: 104-113.
77. Sun Z, Cao Y. Multislice CT angiography assessment of left coronary artery: correlation between bifurcation angle and dimensions and development of coronary artery disease. Eur J Radiol . 2011; 79: e90-95.
78. Chaichana T, Sun Z, Jewkes J. Computation of haemodynamics in the left coronary artery with variable angulations. J Biomech . 2011; 44: 1869-1878.
79. Sun Z, Ng KH, Ramli N. Biomedical imaging research: a fast emerging area for interdisciplinary collaboration. Biomed Imaging Intervent J . 2011; 7(3) e 21.
80. Lawrence-Brown M, Stanley B, Sun Z, Semmens JB, Liffman K. Stress and strain behaviour modelling of the carotid bifurcation. ANZ J Surg . 2011; 81: 810-816.
81. Ng C, Sun Z. Development of an online automatic diagnostic reference levels management system for digital radiography: a pilot experience. Comput Methods Prog Biomed . 2011; 103: 145-150.
82. Al Moudi M, Sun Z, Lenzo N. Diagnostic value of SPECT, PET and PET/CT in the diagnosis of coronary artery disease: A systematic review. Biomed Imaging Intervent J . 2011; 7(2): e 1-9.
83. Sun Z, Can Y. Computed tomography imaging of patients with headache: findings and clinical indications. J Med Imaging Health Informatics . 2011; 1: 21-26.
84. Wong KK, Inthavong K, Sun Z, Liow K, Tu J. In-vivo experimental and numerical studies of cardiac flow in right atrium. HKIE Transactions . 2010; 17 (4): 73-78.
85. Sun Z, Cao Y. Multislice CT virtual endoscopy of aortic dissection: A pictorial essay. World J Radiol . 2010; 28: 440-448.
86. Sun Z. Multislice CT angiography in the diagnosis of coronary artery disease: technical developments, radiation dose and diagnostic value. World J Cardiol . 2010; 26: 333-343.
87. Sun Z, Cao Y, Ng C. Dual-source CT virtual intravascular endoscopy for assessing aortic dissection: A preliminary study. Int J Comput Assist Radiol Surg . 2010; 5: S51-S52.
88. Cao Y, Sun Z, Shang Y, Jiang B, Ma X. Aortic dissection: identification of entry site with CT virtual intravascular endoscopy. Biomed Imaging Intervent J . 2010; 3 e22: 1-7.
89. Sun Z, Ng C. Dual source CT angiography in aortic stent grafting: An in vitro aorta phantom studyof image noise and radiation dose. Acad Radiol . 2010; 17: 884-893.
90. Sun Z, Ng KH, Sarji SA. Is use of computed tomography justified in clinical practice? Part IV: Application in paediatric imaging. Singapore Med J . 2010; 51: 457-463.
91. Sun Z, Ng KH. Multislice CT angiography in cardiac imaging: Part III: Radiation risk and dose reduction. Singapore Med J . 2010; 51: 374-380.
92. Sun Z, Ng KH. Multislice CT angiography in the cardiac imaging: Part II: Diagnostic applications in coronary artery disease. Singapore Med J . 2010; 51: 282-289.
93. Sun Z, Ng KH, Vijayananthan A. Is use of computed tomography justified in clinical practice? Part I: Application in the emergency department. Singapore Med J . 2010; 51: 200-206.
94. Field L, Sun Z. Multislice CT angiography of the plantar arch. Biomed Imaging Intervent J . 2010; 6(1) e10: 1-7.
95. Sun Z. Multislice CT angiography in cardiac imaging: prospective ECG-gating or retrospective ECG-gating? Biomed Imaging Intervent J . 2010; 6(1) e4, 1-7.
96. Chaichana T, Sun Z. Identification and characterisation of coronary plaques with CT virtual intravascular endoscopy: A pictorial review. Atherosclerosis Suppl . 2010; 11: 18-18.
97. Sun Z, Al Dosari S, Ng C, Al-Mumntshari A, Almaliky S. Multislice CT virtual intravascular endoscopyof pulmonary embolism: A pictorial review. Korean J Radiol . 2010; 11: 222-230.
98. Ng C, Sun Z. Development of an online automatic computed radiography dose data mining program: A preliminary study. Comput Methods Prog Biomed . 2010; 97: 48-52.
99. Sun Z, Almutairi A. Diagnostic accuracy of 64-slice CT angiography for the detection of coronary in-stent restenosis: A meta-analysis. Eur J Radiol . 2010; 73: 266-273.
100. Sun Z, Chaichana T. Fenestrated stent graft repair of abdominal aortic aneurysm: Hemodynamic analysis of effect of fenestrated stents on renal arteries. Korean J Radiol . 2010; 11: 95-106.
101. Sun Z, Dimpudus F, Adipranoto JD, Nugroho J. CT virtual intravascular endoscopy assessment of coronary artery plaques: A preliminary study. Eur J Radiol . 2010; 75: e112-e119.
102. Almutairi A, Sun Z, Ng C, Al-Safran Z, Mulla A, Al-Jamaan A. Optimal scanning protocols of 64-slice CT angiography in coronary artery stents: An in vitro phantom study. Eur J Radiol . 2010; 74: 156-160.
103. Sun Z. Endovascular repair of abdominal aortic aneurysm: Current status and future directions. World J Radiol . 2009; 1: 63-71
104. Sun Z, Squelch A, Bartlett A, Cunningham K, Lawrence-Brown M. 3D stereoscopic visualization in fenestrated stent grafts. Cardiovasc Intervent Radiol . 2009; 32: 1053-1058.br> 105. Al Shahaimi A, Ababtain K, Sun Z. Diagnostic value of non-invasive imaging techniques in the detection of carotid artery stenosis: A systematic review. Radiographer . 2009; 56: 14-18.
106. Sun Z, Halkett G. Computed tomography and radiation dose: is the technique appropriately used for imaging the children? Australasian Med J . 2009; 1: 33-35 (editorial).
107. Sun Z, Lawrence-Brown M. CT virtual endoscopy and 3D stereoscopic visualization in the evaluation of coronary stenting. Biomed Imaging Intervent J . 2009; 4 e (22), 1-6.
108. Sun Z. The promise of synchrotron radiation in medical science. Australasian Med J . 2009; 1: 1-5 (editorial).
109. Sun Z. Helical CT angiography of fenestrated stent grafting of abdominal aortic aneurysms. Biomed Imaging Intervent J . 2009; 2: e 3: 1-9. 110. Sun Z, Mwipatayi B, Allen Y, Hartley D, Lawrence-Brown M. Multislice CT virtual intravascular endoscopy in the evaluation of fenestrated stent graft repair of abdominal aortic aneurysms: A short-term follow-up. ANZ J Surg . 2009; 79: 836-840.
111. Sun Z, Chaichana T. Investigation of hemodynamic effect of stent wires on renal arteries in patients with abdominal aortic aneurysms treated with suprarenal stent grafts. Cardiovasc Interv Radiol . 2009; 32: 647-657.
112. Sun Z, Allen Y, Mwipatayi B, Hartley D, Lawrence-Brown M. Multislice CT angiography of fenestrated endovascular stent grafting of abdominal aortic aneurysms: A pictorial review of 2D/3D visualizations. Korean J Radiol . 2009; 10: 285-293.
113. Lawrence-Brown M, Sun Z, Semmens JB, Liffman K, Sutalo I, Hartley D. Type II endoleaks: When is intervention indicated and the index of suspicion for type I or III? J Endovasc Ther. 2009; (Suppl II) 16: I 106-I 118.
114. Sun Z, Davidson R, Lin CH. Multislice CT angiography in the assessment of coronary artery in-stent restenosis: A systematic review. Eur J R . 2009; 69: 489-495.
115. Sun Z, Allen Y, Mwipatayi B, Hartley D, Lawrence-Brown M. Multislice CT angiography in the follow-up of fenestrated endovascular grafts: Effect of slice thickness on 2D and 3D visualization of the fenestrated stents. J Endovasc Ther . 2008; 15: 417- 426.
116. Sun Z, Mwipatayi B, Allen Y, Hartley D, Lawrence-Brown M. Multislice CT angiography of fenestrated endovascular grafts: A pictorial essay. Int J Comput Assist Radiol Surg . 2008; 3 (supp l): S343-344.
117. Sun Z. Multislice CT angiography in post-aortic stent grafting: optimization of scanning protocols for virtual intravascular endoscopy. Int J Comput Assist Radiol Surg . 2008; 3: 19-26.
118. Sun Z, Allen Y, Nadkarni S, Wright R, Hartley D, Lawrence-Brown M. CT virtual intravascular endoscopy in the visualization of fenestrated endovascular grafts. J Endovasc Ther . 2008; 15:42-51.
119. Sun Z, Lin CH, Davidson R, Dong C, Liao Y. Diagnostic value of 64-slice CT angiography in coronary artery disease: A systematic review. Eur J R . 2008; 67: 78-84.
120. Sun Z, ODonnell M, Winder R, Ellis P, Blair P. Effect of suprarenal fixation of aortic stent grafts on renal ostium: Assessment of morphological changes by virtual intravascular endoscopy. J Endovasc Ther . 2007; 14: 650-660.
121. Sun Z, Allen Y, Fitzsimmons B, Hartley D, Lawrence-Brown M. Evaluation of CT virtual intravascular endoscopy in the visualisation of aortic ostium in patients undergoing fenestrated stent grafts: a preliminary study. Int J Comput Assist Radiol Surg . 2007; 2: S37-38.
122. Sun Z, Chaichana T, Nipawan T, Allen Y, Hartley D, Lawrence-Brown MMD. Simulation of blood flow in abdominal aortic aneurysms pre-and post-fenestrated stent graft repair: A preliminary study. Int J Comput Assist Radiol Surg . 2008; 3 (suppl 1): S66.
123. McCann K, Lim L, Tomlinson G, Way J, Alshamakhi J, Ong C, Sun Z. Optimisation of radiation dose and image quality in 3D multi-detector CT angiography in abdominal aortic aneurysm: in vitro aorta phantom study. Radiographer . 2007; 51: 18-22.
124. ODonnell, Sun Z, Winder J, Lau LL, Ellis PK, Blair PH. Suprarenal fixation of endovascular aortic stent grafts: assessment of medium-term to long-term renal function by analysis of juxtarenal stent morphology. J Vasc Surg . 2007; 45: 694-700.
125. Sun Z. Multislice CT angiography in abdominal aortic aneurysm treated with endovascular stent grafts: evaluation of 2D and 3D visualisations. Biomed Imaging Intervent J . 2007; 3: e20: 1-9.
126. Sun Z. Multislice CT angiography in aortic stent grafting: relationship between image noise and body mass index. Eur J R. 2007; 61: 534-540.
127. Sun Z, Mwipatayi B, Semmens J, Lawrence-Brown M. Short to mid-term outcomes of fenestrated endovascular grafting of aortic aneurysms: A systematic review. J Endovasc Ther . 2006; 13: 6: 747-753.
128. Sun Z. Diagnostic accuracy of multislice CT angiography in peripheral vascular disease. J Vasc Intervent Radiol. 2006; 17: 1915-1921.
129. Sun Z, Jing W. Diagnostic value of multislice CT angiography in coronary artery disease: A meta-analysis. Eur J R . 2006; 60: 279-286.
130. Sun Z. Diagnostic value of color duplex ultrasound in the follow-up of endovascular repair of abdominal aortic aneurysm. J Vasc Intervent Radiol . 2006; 17: 759-764.
131. Sun Z. 3D multislice CT angiography in post-aortic stent grafting: A pictorial essay. Korean J Radiol . 2006; 7: 205-211.
132. Sun Z, Ferris C. Optimal Scanning protocol of multislice CT virtual intravascular endoscopy in pre-aortic stent grafting: in vitro phantom study. Eur J R . 2006; 58: 310-316.
133. Sun Z, Stevenson G. Short to mid-term effects of transrenal fixation of aortic stent grafts on renal function: A systematic review. Radiology . 2006; 240: 65-72.
134. Sun Z. Three-Dimensional visualization of suprarenal aortic tent-grafts: Evaluation of migration in midterm follow-up. J Endovasc Ther . 2006; 1: 85-93.
135. Sun Z, Winder J, Kelly B, Ellis P, Kennedy P, Hirst D. Diagnostic value of CT virtual intravascular endoscopy in aortic stent grafting. J Endovasc Ther. 2004; 11: 13-25.
136. Sun Z, Winder J, Kelly B, Ellis P, Kennedy P, Hirst D. Assessment of VIE image quality using helical CT angiography: in vitro phantom study. Comput Med Imaging Graph. 2004; 28:3-12.
137. Sun Z, Zheng H. Cross-sectional area reduction of the renal ostium by suprarenal stent wires: in vitro phantom study by CT virtual angioscopy. Comput Med Imaging Graph . 2004; 28: 345-351.
138. Sun Z, Zheng H. Effect of suprarenal stent struts on the renal ostia with ostial calcification observed in CT virtual intravascular endoscopy. Eur J Vasc Endovasc Surg . 2004; 28: 534-542.
139. Sun Z. Transrenal fixation of aortic stent grafts: current status and future directions. J Endovasc Ther . 2004; 11: 539-549.
140. Sun Z, Gallagher E. Multislice CT virtual intravascular endoscopy for abdominal aortic aneurysm stent grafts. J Vasc Intervent Radiol . 2004; 15: 961-970.
141. Sun Z, Zheng H. Helical CT angiography of aortic stent grafting: Comparison of three-dimensional rendering techniques. Lecture Notes in Computer Science. 2004; 3314: 544-549.
142. Sun Z, Winder J, Kelly B, et al. Three-dimensional virtual endoscopy of the suprarenal stent component in endovascular repair of abdominal aortic aneurysms. Br J Surg . 2003; 90: 498-498.
143. Sun Z, Winder J, Kelly B, Ellis P, Hirst D. CT virtual intravascular endoscopy of abdominal aortic aneurysms treated with suprarenal endovascular stent grafting. Abdom Imaging . 2003; 28(4): 580-587.
144. Sun Z. Helical CT angiography of abdominal aortic aneurysms treated with suprarenal stent grafting: a pictorial essay. Cardiovasc Intervent Radiol . 2003; 26(3) 290-295.
145. Winder J, Sun Z, Kelly B, Ellis P, Hirst D. An abdominal aortic aneurysm and stent graft phantom manufactured by medical rapid prototyping. J Med Eng Tech. 2002; 26(2): 75-78.
146. Sun Z, Lin C-H. Coronary CT Angiography in Coronary Artery Disease: from Diagnosis to Prevention. Heart Res Open J. 2014; 1(1): 1-9. doi: 10.17140/HROJ-1-101
147. Sun Z, Squelch A. 3D printed models of complex anatomy in cardiovascular disease. Heart Res Open J. 2015; 2(3): 103-108. doi: 10.17140/HROJ-2-118
148. Sun Z. The PLATFORM trial: an insight into the improved value of using FFRCT for reduction of invasive angiographic procedures. Heart Res Open J. 2015; 2(5): e13-e17. doi: 10.17140/HROJ-2-e005
149. Sun Z. Effects of iterative reconstruction on the diagnostic assessment of coronary calcium scores. Heart Res Open J. 2016; 2(5): 137-143. doi: 10.17140/HROJ-2-125

Giuseppe De Luca, MD, PhD

Aggregate Professor of Cardiology
Chief Interventional Cardiology
Eastern Piedmont University
C.so Mazzini 18, 28100
Novara, Italy

BiographyResearch InterestScientific ActivitiesPublications

Dr. Luca is Chief of Interventional Cardiology at the Azienda Ospedaliera-Universitaria “Maggiore della Carità” in Novara, Italy. Having performed over 3,000 coronary angioplasties, Prof. De Luca is a major worldwide expert in the setting of acute myocardial infarction. He is a member of the Scientific Committee of the European Association of Percutaneous Coronary Intervention (EAPCI) and the recipient of several prestigious international scientific awards, including the Thomas J. Linnemeier Spirit of Interventional Cardiology Young Investigator Award. An author of over 100 peer-reviewed journal publications, Prof. De Luca is Aggregate Professor of Cardiology at Eastern Piedmont University. He is Director of the University’s Laboratory of Molecular Cardiology, where he is currently conducting several studies on pharmacogenomics, genetic predisposition to atherosclerosis, no-reflow phenomenon, and left ventricular remodeling after STEMI.

His current research interests include: STEMI; platelet and antiplatelet therapies; coronary stenting; genetic polymorphisms; Atherosclerosis

MEMBERSHIP OF INSTITUTIONS AND ASSOCIATIONS

• Member of the Italian Society of Cardiology
• European Association of Percutaneous Coronary Intervention (EAPCI)

Total number of publications with IF (per extenso) 192

Burton M. Altura, PhD

Professor of Physiology, Pharmacology & Medicine
State University of New York- Downstate Medical Center
450 Clarkson Ave., MSC-31
Brooklyn, NY 11203, USA

BiographyResearch InterestScientific ActivitiesPublications

Dr. Altura is a Professor at Suny Downstate Medical Center in USA. He received his PhD from Newyork University School of Medicine in the year 1964. He serves as an Ad Hoc Reviewer and also reviewer for various journals and funding organizations.

His research interests include the role of magnesium, sphingolipids and lipid messengers in vascular biology and disease processes, such as stroke, diabetes mellitus and atherogenesis. An additional major interest is the role of alcohol and substances of abuse in stroke etiology.

SERVICE FUNCTIONS

• Ad Hoc Reviewer, NIH, NSF, and USDA study sections
• Reviewer for various journals and funding organizations

SELECTED PUBLICATIONS

1. Li M, Zheng T, Wang J, Altura BT, and Altura BM. Extracellular magnesium regulates effects of vitamin B6, B12 and folate on homocysteinemia-induced depletion of intracellular magnesium ions in canine cerebral smooth muscle cells: possible relationship to [ Ca2+]i, atherogenesis and stroke. Neurosci Lett. 1999; 274, 83-86.
2. Li W, Zheng T, Wang J, Altura BT, and Altura BM. Pyrrolidine dethiocarbamate prevents ethanol-induced elevation of [Ca2+]i in cultured canine carebral vacsular smooth muscle cells. Neurosci Lett. 1999; 266, 205-208.
3. Yang ZW, Wang J, Zheng T, Altura BT, and Altura BM. Low [Mg2+]o, induces contraction of cerebral arteries: roles of tyrosine and mitogen-activated protein kinases. Am J Physiol Heart Circ Physiol. 2000; 279, H185-H194.
4. Yang ZW, Gebrewold A, Nowakowski M, Altura BT, and Altura BM. Mg2+-induced endothelium-dependent relaxation of blood vessels and blood pressure lowering: role of NO. Am J Physiol Regulatory Integrative Comp Physiol. 2000; 278, R628-R639.
5. Zheng T, Li WS, Wang J, Altura BT, and Altura BM. Sphingomyelinase and ceramide analogs induce contraction and rises in [Ca2+]i in canine cerebral vascular muscle. Am J Physiol Heart Circ Physiol. 2000; 278, H1421-H1428.

Joslin B. Leasca, MSN, DNP, FNP-BC

Clinical Assistant Professor of Nursing
School of Nursing
Sacred Heart University
5151 Park Avenue
Fairfield, CT 06825, USA

BiographyResearch InterestScientific ActivitiesPublications

Dr. Leasca completed the Family Nurse Practitioner program at the University of Rhode Island in 1999 and earned the inaugural doctoral degree; DNP, at the University of Rhode Island in May 2012.
Dr. Leasca is a clinical expert in adult and adolescent cardiac and pulmonary disease, as well as primary care, and has earned state and national recognition for her innovative approaches to healthcare for these populations.
Dr. Leasca is an assistant Clinical Professor in the College of Health Professions, Sacred Heart University. Dr. Leasca is a Family Nurse Practitioner in a community practice which combines urgent care and primary care for families in her community following the Patient Centered Medical Home model.
When Dr. Leasca is not immersed in clinical affairs, she is most likely on her boat in Potters Pond, Rhode Island with her husband and the two best Golden Retrievers in the world; Body and Brady.

Her research interests include: Effect of improved patient outcomes via the Patient Centered Medical Home model system of care. Her current research is focused on reduction of exacerbation events of chronic cardiac or pulmonary disease within a Patient Centered Medical Home and the reduction of hospital readmission for same.

MEMBERSHIPS

• American Academy of Nurse Practitioners
• National League of Nursing
• National Council of State Boards of Nursing
• Rhode Island State Nurses Association
• Sigma Theta Tau Honor Society - Academic Appointee
• Doctors of Nursing Practice
• Rhode Island APRN Coalition – Founding Member


AWARDS

• Patient Centered Medical Home Grant, (2013 – 2018)
• Carol B. Lietar Excellence Award, 2007
• American Academy of Nursing Practitioners Rhode Island State Excellence, 2005
• Walden University Alpha Sigma Lambda Undergraduate Honor Society, 2012

Yiru Guo, MD, FAHA

Professor of Medicine, Pharmacology, Toxicology, Physiology and Biophysics
Division of Cardiovascular Medicine
Director, the Murine Research Laboratory
Leader, the NIH-funded Murine Surgery, Physiology and Transgenic Core
Institute of Molecular Cardiology, University of Louisville
511 S Floyd Street, MDR Building Room 128D
Louisville, KY 40202, USA

BiographyResearch InterestScientific ActivitiesPublications

Dr. Guo is a Professor of Medicine/the Division of Cardiology at University of Louisville. He has been the Director of Murline Research Laboratory since 1997. He is also the Director of Surgery and Transgenic core in the NIH PPG. In 2007, he was elected as the Fellow of the national AHA(FAHA) because of his major and productive contributors to the cardiovascular basic science. His research has been supported by several NIH grants including R01, PPG and CAESAR grants. He has been co-authored over 60 peer-reviewed publications, several book chapters, and has been invited to speak at several international scientific meetings and research institutes/universities.

His research interests include: Elucidating the mechanisms of ischemic-pharmacologic and ischemia/reperfusion model in genetically engineered animals, Studying protection of ischemic myocardium by using gene and/or cell therapy, Elucidating adaptations to ischemia/reperfusion injury in the aging heart.

HONORS AND AWARDS


• (1998-1999) Postdoctoral Fellowship Award, American Heart Association, Kentucky Affiliate, USA
• (11/1998) Travel Award (American Heart Association, Cardiovascular Surgery and Anesthesia Council), Dallas, TX, USA
• (1999-2000) Postdoctoral Fellowship Award, American Heart Association, Ohio Valley Affiliate, USA
• (06/2000) Organizer of the XXII Annual Sessions of the American Section of the International Society for Heart Research (ISHR), Louisville, KY, USA (June 14-18, 2000)
• (05/2001) Honored and Visiting Professor in the Institute of Cardiovascular Diseases of Capital University of Medical Science, the Heart Center of Beijing Chao Yang Hospital, Beijing, China
• (11/2001) Second Place Award in Scientific Importance category in ResearchLouisville Competition, Louisville, KY, USA
• (11/2001) Honored Member in Good Standing (the International Society for Heart Research-American Section)
• (07/2002) Nominated as International Scientist of the Year from the International Biographical Centre of Cambridge (IBC)
• (11/2003) Travel Award (American Heart Association, Council on Basic Cardiovascular Sciences), Dallas, TX, USA
• (11/2007) Fellow of the American Heart Association (Council on Basic Cardiovascular Sciences), USA
• (08/14/2011) Chairing Section entitled Cell Transplantation and Cardiac Regeneration: From Bench to Bedside. China Heart Congress (CHC) and International Heart Forum Beijing (IHF), China


PROFESSIONAL MEMBERSHIPS AND ACTIVITIES


• (1986-1996) Member of Chinese Cardiothoracic and Vascular Surgery Society
• (1990-1996) Member of Chinese Biomedical Engineering Society
• (1996-present) Member of the American Heart Association (Council on Cardio-Thoracic and Vascular Surgery)
• (1997-present) Member of the Oxygen Society of USA
• (1997-present) Member of the International Society for Heart Research (ISHR)-American Section
• (1999-present) Member of the American Association for the Advancement of Science (AAAS)
• (2000) One of organizers of the XXII Annual Sessions of the American Section of the International Society for Heart Research (ISHR), Louisville, KY, June 14-18, 2000
• (2001-present) Member of the American Heart Association (Council on Basic Cardiovascular Sciences)
• (2004-present) Member of Interdisciplinary Research Group on Aging in Louisville
• (2004-2006) Professional Member of the American Heart Association (Councils on Basic Cardiovascular Sciences and Cardiothoracic and Vascular Surgery)
• (2006-present) Premium Professional Member of the American Heart Association (Councils on Basic Cardiovascular Sciences, Cardiothoracic and Vascular Surgery and Interdisciplinary Working Group on Atherosclerotic Peripheral Vascular Disease)
• (2007-present) Fellow of the American Heart Association (FAHA, Councils on Basic Cardiovascular Sciences)
• (2010-present) Member of NIH CAESAR Consortium Operations Committee (COC), USA
• (2011-present) Member of International Steering Committee, China Heart Congress and International Heart Forum, Beijing, China

Original Research Articles


1. Guo JH, Guo JQ, Guo Y, Wu XJ. Calculation of the diameter of pulmonary arterial orifile and transannular patch width in radical treatment of tetralogy of Fallot. Chinese Circulation. 1992; 7: 196-199. doi:
2. Wu XJ, Qi ZT, Guo Y, Guo JQ. Effect of cryopreservation on the mechanical behavior thoracic aortic allografts. Chinese J. Dial and Artif Organs. 1992; 3: 4-6. doi:
3. Chang Q, Guo JQ, Guo Y, Wu XJ. In vitro hydrolic simulation of Fontan circulation and flow visualization and hemodynamic study. Proceedings of 1st ICBME Shanghai 5th ISBMRE. 1992; 1: 236-237. doi:
4. Chang Q, Guo JQ, Guo Y, Wu XJ. Hemodynamic appreciation of Fontan procedure using the method of mathematical analysis of pulse wave. Proceedings of 1st ICBME Shanghai 5th ISBMRE. 1992; 1: 103-110. doi:
5. Wu XJ, Guo JQ, Guo Y, Chang Q. Clinical basis for the research and practice of human circulation duplicator attaching with clinical information including left heart cathertization of 74 cases. Proceedings of 1st ICBME 92 Shanghai 5th ISBMRE. 1992; 1: 203-210. doi:
6. Wu XJ, Guo JQ, Guo Y, Chang Q. The influence of left ventricular morphology size and motion on hydrodynamic character of left human circulation-background knowledge of human circulation duplication from clinical observation. J Biomed Eng. 1992; 9: 353-358. doi:
7. Wu XJ, Chang Q, Guo Y, Guo JQ. Study of aortic valve allograft as standard comparative valve in hydrodynamic characteristic testing heart valve prosthesis mounted with trestle tested in pulse flow. J Biomed Eng. 1993; 10(1): 27-35. doi:
8. Wu XJ, Chang Q, Guo Y, Guo JQ. Comparison of allograft aortic valve orifice area as estimated by the gorlin formula and the continuity equation. ACTA Academia Medicine Science. 1993; 15: 411-416. doi:
9. Guo Y, Guo JQ. Directing gene transfer into rat myocardium in vivo. J Beijing Med Univ. 1994; 26: 128-130. doi:
10. Chen LW, Guo Y, Guo JQ. A tentative application of pro-urokinase gene suture for vascular anastomosis. J Beijing Med Univ. 1994; 26: 134. doi:
11. Zhu XD, Liu YL, Xiao MD, Guo Y. Correction of complex congenital hearts anomalies with Rastelli operation. International Conference on Extracorporeal Circulation and Thoracic & Cardiovascular Surgery. Beijing. 1994; 10: 136-137. doi:
12. Wu XJ, Guo JH, Guo Y, Guo JQ. Evaluation and similarity of the duplicators cardiac cycle in vivo. J Beijing Biomed Eng. 1994; 13: 91-92. doi:
13. Bolli R, Bhatti ZA, Tang XL, Qiu Y, Guo Y, Jadoon AK. Evidence that late preconditioning against myocardial stunning in conscious rabbits is triggered by the generation of nitric oxide. Circ Res. 1997; 81(1): 42-52. doi:
14. Bolli R, Manchikalapudi S, Tang XL, et al. The protective effect of late preconditioning against myocardial stunning in conscious rabbits are mediated by nitric oxide synthase evidence that nitric oxide acts both as a trigger and as a mediator of the late phase of ischemic preconditioning. Circ Res. 1997; 81(6): 1094-1107. doi:
15. Takano H, Tang XL, Qiu Y, Guo Y, French BA, Bolli R. Nitric oxide donors induce late preconditioning against myocardial stunning and infarction in conscious rabbits via an antioxidant-sensitive mechanism. Circ Res. 1998; 83(1): 73-84. doi:
16. Guo Y, Wu WJ, Qiu Y, Tang XL, Yang Z, Bolli R. Demonstration of an early and a late phase of ischemic preconditioning in mice. Am J Physiol. 1998; 275(4(2)): H1375-H1387. doi:
17. Yuan SM, Chang Q, Guo Y and Guo JQ. In vitro pulsatile flow visualization on extracardiac conduits for the right ventricular outflow tract reconstruction qualitative considerations. Kaohsiung J Med Sci. 1998; 14(5): 258-265. doi:
18. Guo Y, Jones WK, Xuan Y, et al. The late phase of ischemic preconditioning is abrogated by targeted disruption of the inducible NO synthase gene. Proc Natl Acad Sci USA. 1999; 96(20): 11507-11512. doi:
19. Guo Y, Bao W, Wu JW, Shinmura K, Tang XL, Bolli R. Evidence for an essential role of cyclooxygenase-2 as a mediator of the late phase of ischemic preconditioning in mice. Basic Res Cardiol. 2000; 95(6): 479-484. doi:
20. Guo Y, Bolli R, Bao W, et al. Targeted deletion of the A3 adenosine receptor confers resistance to myocardial ischemic injury and does not prevent early preconditioning. J Mol Cell Cardiol. 2001; 33(4): 825-830. doi:
21. Li Q, Bolli R, Qiu Y, Tang XL, Guo Y, French BA. Gene therapy with extracellular superoxide dismutase protects conscious rabbits against myocardial infarction. Circulation. 2001; 10(103(14)): 1893-1898. doi:
22. Xuan YT, Guo Y, Han H, Zhu Y, Bolli R. An essential role of the JAK-STAT pathway in ischemic preconditioning. Proc Natl Acad Sci USA. 2001; 98(16): 9050-9055. doi:
23. Chen L, Hahn H, Wu G, et al. Opposing cardioprotective actions and parallel hypertrophic effects of delta PKC and epsilon PKC. Proc Natl Acad Sci USA. 2001; 98(20): 11114-11119. 24. Ping P, Song C, Zhang J, et al. Formation of protein kinase C(epsilon)-Lck signaling modules confers cardioprotection. J Clin Invest. 2002; 109(4): 499-507. doi:
25. Wang Y, Guo Y, Zhang SX, et al. Ischemic preconditioning upregulates inducible nitric oxide synthase in cardiac myocyte. J Mol Cell Cardiol. 2002; 34(1): 5-15. doi:
26. Black RG Jr, Guo Y, Ge ZD, et al. Gene dosage-dependent effects of cardiac-specific overexpression of the A3 adenosine receptor. Circ Res. 2002; 91(2): 165-172. doi:
27. Sasaki N, Murata M, Guo Y, et al. Mcc-134, a single pharmacophore, opens surface ATP-sensitive potassium channels, blocks mitochondrial ATP-sensitive potassium channels, and suppresses preconditioning. Circulation. 2003; 107(8): 1183-1188. doi:
28. Li Q, Guo Y, Xuan YT, et al. Gene Therapy with Inducible Nitric Oxide Synthase Protects against Myocardial Infarction via a Cyclooxygenase-2-dependent Mechanism. Circ Res. 2003; 92(7): 741-748. doi:
29. Baines CP, Song CX, Zheng YT, et al. Protein Kinase C epsilon Interacts With and Inhibits the Permeability Transition Pore in Cardiac Mitochondria. Circ Res. 2003; 92(8): 873-880. doi:
30. Xuan YT, Guo Y, Zhu Y, et al. Mechanism of cyclooxygenase-2 upregulation in late preconditioning. J Mol Cell Cardiol. 2003; 35(5): 525-537. doi:
31. Guo Y, Stein AB, Wu WJ, et al. Administration of a CO-releasing molecule at the time of reperfusion reduces infarct size in vivo. Am J Physiol Heart Circ Physiol. 2004; 286(5): H1649-H1653. doi:
32. Dawn B, Guo Y, Rezazadeh A, et al. Tumor necrosis factor-alpha does not modulate ischemia/reperfusion injury in naive myocardium but is essential for the development of late preconditioning. J Mol Cell Cardiol. 2004; 37(1): 51-61. doi:
33. Dawn B, Xuan YT, Guo Y, et al. IL-6 plays an obligatory role in late preconditioning via JAK-STAT signaling and upregulation of iNOS and COX-2. Cardiovasc Res. 2004; 64(1): 61-71. doi:
34. Kucia M, Dawn B, Hunt G, et al. Cells expressing early cardiac markers reside in the bone marrow and are mobilized into the peripheral blood after myocardial infarction. Circ Res. 2004; 95(12): 1191-1209. doi:
35. Stein AB, Guo Y, Tan W, et al. Administration of a CO-releasing molecule induces late preconditioning against myocardial infarction. J Mol Cell Cardiol. 2005; 38(1): 127-134. doi:
36. Martindale JJ, Wall JA, Martinez-Longoria DM, et al. Overexpression of Mitogen-activated Protein Kinase Kinase 6 in the Heart Improves Functional Recovery from Ischemia in Vitro and Protects against Myocardial Infarction in Vivo. J Biol Chem. 2005; 280(1): 669-676. doi:
37. Syed FM, Hahn HS, Odley A, et al. Proapoptotic effects of caspase-1/interleukin-converting enzyme dominate in myocardial ischemia. Circ Res. 2005; 96(10): 1103-1109. doi:
38. Guo Y, Stein AB, Wu WJ, et al. Late preconditioning induced by NO donors, adenosine A1 receptor agonists, and δ1-opioid receptor agonists is mediated by iNOS. Am J Physiol Heart Circ Physiol. 2005; 289(5): H2251-H2257. doi:
39. Xuan YT, Guo Y, Zhu Y, et al. Role of the protein kinase C-epsilon-Raf-1-MEK-1/2-p44/42 MAPK signaling cascade in the activation of signal transducers and activators of transcription 1 and 3 and induction of cyclooxygenase-2 after ischemic preconditioning. Circulation. 2005; 112(13): 1971-1978. doi:
40. Li Q, Guo Y, Tan W, et al. Gene therapy with iNOS provides long-term protection against myocardial infarction without adverse functional consequences. Am J Physiol Heart Circ Physiol. 2006; 290(2): H584-H589. doi:
41. Dawn B, Guo Y, Rezazadeh A, et al. Postinfarct Cytokine Therapy Regenerates Cardiac Tissue and Improves Left Ventricular Function. Circ Res. 2006; 98(8): 1098-1105. doi:
42. Stein AB, Bolli R, Guo Y, et al. The late phase of ischemic preconditioning induces a prosurvival genetic program that results in marked attenuation of apoptosis. J Mol Cell Cardiol. 2007; 42(6): 1075-1085. doi:
43. Xuan YT, Guo Y, Zhu Y, Wang OL, Rokosh G, Bolli R. Endothelial Nitric Oxide Synthase Plays an Obligatory Role in the Late Phase of Ischemic Preconditioning by Activating the Protein Kinase C{epsilon}-p44/42 Mitogen-Activated Protein Kinase-pSer-Signal Transducers and Activators of Transcription1/3 Pathway. Circulation. 2007; 116(5): 535-544. doi:
44. Hu X, Dai S, Wu WJ, et al. Stromal Cell-Derived Factor-1{alpha} Confers Protection Against Myocardial Ischemia/Reperfusion Injury. Role of the Cardiac Stromal Cell-Derived Factor-1{alpha}-CXCR4 Axis. Circulation. 2007; 116(6): 654-663. doi:
45. Li Q, Guo Y, Tan W, et al. Cardioprotection Afforded by Inducible Nitric Oxide Synthase Gene Therapy Is Mediated by Cyclooxygenase-2 via a Nuclear Factor-{kappa}B Dependent Pathway. Circulation. 2007; 116(14): 1577-1584. doi:
46. Benjamin IJ, Guo Y, Srinivasan S, et al. CRYAB and HSPB2 deficiency alters cardiac metabolism and paradoxically confers protection against myocardial ischemia in aging mice. Am J Physiol Heart Circ Physiol. 2007; 293(5): H3201-H3209. doi:
47. Guo Y, Li Q, Wu W, et al. Endothelial nitric oxide synthase is not necessary for the early phase of ischemic preconditioning in the mouse. J Mol Cell Cardiol. 2008; 44(3): 496-501. doi:
48. Dawn B, Tiwari S, Kucia MJ, et al. Transplantation of Bone Marrow-Derived Very Small Embryonic-like Stem Cells (Vsels) Attenuates Left Ventricular Dysfunction and Remodeling after Myocardial Infarction. Stem Cells. 2008. doi: 10.1634/stemcells.2007-0715.
49. Zuba-Surma EK, Kucia M, Dawn B, Guo Y, Ratajczak MZ, Bolli R. Bone marrow-derived pluripotent very small embryonic-like stem cells (VSELs) are mobilized after acute myocardial infarction. J Mol Cell Cardiol. 2008; 44(5): 865-873. doi: 10.1016/j.yjmcc.2008.02.279.
50. Wang GW, Guo Y, Vondriska TM, et al. Acrolein consumption exacerbates myocardial ischemic injury and blocks nitric oxide-induced PKCepsilon signaling and cardioprotection. J Mol Cell Cardiol. 2008; 44(6): 1016-1022. doi: 10.1016/j.yjmcc.2008.03.020.
51. Flaherty MP, Guo Y, Tiwari S, et al. The role of TNF-alpha receptors p55 and p75 in acute myocardial ischemia/reperfusion injury and late preconditioning. J Mol Cell Cardiol. 2008; 45(6): 735-741. doi: 10.1016/j.yjmcc.2008.08.014.
52. West MB, Rokosh G, Obal D, et al. Cardiac myocyte-specific expression of inducible nitric oxide synthase protects against ischemia/reperfusion injury by preventing mitochondrial permeability transition. Circulation. 2008; 118(19): 1970-1978. doi: 10.1161/CIRCULATIONAHA.108.791533.
53. Li Q, Guo Y, Ou Q, et al. Gene Transfer of Inducible Nitric Oxide Synthase Affords Cardioprotection by Upregulating Heme Oxygenase-1 Via a Nuclear Factor-{kappa}B-Dependent Pathway. Circulation. 2009; 120(13): 1222-1230. doi: 10.1161/CIRCULATIONAHA.108.778688.
54. Sanganalmath SK, Stein AB, Guo Y, et al. The beneficial effects of postinfarct cytokine combination therapy are sustained during long-term follow-up. J Mol Cell Cardiol. 2009; 47(4): 528-535. doi: 10.1016/j.yjmcc.2009.07.009.
55. Bolli R, Stein AB, Guo Y, et al. A murine model of inducible, cardiac-specific deletion of STAT3: its use to determine the role of STAT3 in the upregulation of cardioprotective proteins by ischemic preconditioning. J Mol Cell Cardiol. 2011; 50(4): 589-597. doi: 10.1016/j.yjmcc.2011.01.002.
56. Zuba-Surma EK, Guo Y, Taher H, et al. Transplantation of expanded bone marrow-derived very small embryonic-like stem cells (VSEL-SCs) improves left ventricular function and remodeling after myocardial infarction. J Cell Mol Med. 2011; 15(6): 1319-1328. doi: 10.1111/j.1582-4934.2010.01126.x.
57. Li Q, Guo Y, Ou Q, et al. Intracoronary administration of cardiac progenitor cells in mice: A new, improved technique for cell therapy in murine models. Basic Res Cardiol. 2011; 106(5): 849-864. doi: 10.1007/s00395-011-0180-1.
58. Li Q, Guo Y, Wu W, et al. Gene transfer as a strategy to achieve permanent cardioprotection I: rAAV-mediated gene therapy with inducible nitric oxide synthase limits infarct size 1 year later without adverse functional consequences. Basic Res Cardiol. 2011; 106(6): 1355-1366. doi: 10.1007/s00395-011-0207-7.
59. Li Q, Guo Y, Ou Q, et al. Gene transfer as a strategy to achieve permanent cardioprotection II: rAAV-mediated gene therapy with heme oxygenase-1 limits infarct size 1 year later without adverse functional consequences. Basic Res Cardiol. 2011; 106(6): 1367-1377. doi: 10.1007/s00395-011-0208-6.
60. Stein AB, Bolli R, Dawn B, et al. Carbon monoxide induces a late preconditioning-mimetic cardioprotective and antiapoptotic milieu in the myocardium. J Mol Cell Cardiol. 2012; 52(1): 228-236. doi: 10.1016/j.yjmcc.2011.11.005.
61. Guo Y, Sanganalmath SK, Wu W, et al. Identification of Inducible Nitric Oxide Synthase in Peripheral Blood Cells as a Mediator of Myocardial Ischemia/Reperfusion Injury. Basic Res Cardiol. 2012; 107(2): 253. doi: 10.1007/s00395-012-0253-9.
62. Guo Y, Tukaye DN, Wu WJ, et al. The COX-2/PGI2 receptor axis plays an obligatory role in mediating the cardioprotection conferred by the late phase of ischemic preconditioning. PLoS One. 2012; 7(7): e41178. doi: 10.1371/journal.pone.0041178.
63. Guo Y, Flaherty MP, Wu WJ, et al. Genetic background, gender, age, body temperature, and arterial blood pH have a major impact on myocardial infarct size in the mouse and need to be carefully measured and/or taken into account: results of a comprehensive analysis of determinants of infarct size in 1,074 mice. Basic Res Cardiol. 2012; 107(5): 288. doi: 10.1007/s00395-012-0288-y.
64. Cai C, Teng L, Vu D, et al. The Heme Oxygenase 1 Inducer (CoPP) Protects Human Cardiac Stem Cells Against Apoptosis Through Activation of The ERK/Nrf2 Signaling Pathway and Cytokine Release. J Biol Chem. 2012; 287(40): 33720-33732. doi:
65. Hong KU, Li QH, Guo Y, et al. A highly sensitive and accurate method to quantify absolute numbers of c-kit+ cardiac stem cells following transplantation in mice. Basic Res Cardiol. 2013; 108(3): 346. doi: 10.1007/s00395-013-0346-0.
66. Hong KU, Guo Y, Li QH, et al. c-kit+ Cardiac stem cells alleviate post-myocardial infarction left ventricular dysfunction despite poor engraftment and negligible retention in the recipient heart. PloS one. 2014; 9: e96725 doi: 10.1371/journal.pone.0096725.
67. Brooks AC, Guo Y, Singh M, McCracken J, Xuan YT, Srivastava S, Bolli R, Bhatnagar A. Endoplasmic reticulum stress-dependent activation of ATF3 mediates the late phase of ischemic preconditioning. Journal of molecular and cellular cardiology. 2014; 76C: 138-147. doi: 10.1016/j.yjmcc.2014.08.011.

Lorna R. Fiedler, PhD

Research Fellow
Program in Cardiovascular and Metabolic Disorders
Duke-NUS Graduate Medical School Singapore
8 College Road
169857, Singapore

BiographyResearch InterestScientific ActivitiesPublications

Dr. Fiedler has 12 years experience in the cardiovascular field (specifically in cell biology, therapeutics and protein biochemistry) in both an academic and industrial environment. Following 2 years working for a small biotechnology company in Cambridge (cell signalling and complement therapeutics, 2001-2003) she studied for a PhD in extracellular matrix biology signalling and angiogenesis at Cardiff University (2003-2007). She continued to investigate the molecular and cellular mechanisms underlying cardiovascular disease in an academic environment (Cardiff University, UCL and Imperial College London, with secondments in Cambridge and Germany), which has recently led to initiation of a drug discovery programme in collaboration with industrial partners at MRC-Technology and Domainex. Her international reputation and visibility is increasing through regular selection to present at national, international conferences and internal seminars and is reflected in invitations for conference participation and to serve on editorial boards. Her work has also been recognised by a number of awards (for oral and poster presentations), most recently at the BSCR meeting in Reading this year (best poster prize). In addition, in 2013 she was invited to edit a book (Springer publications) and since 2010, have been listed in Whos Who.

Her research interests include: Exploring the role of STE20 MAP4 kinases in cardiovascular pathology, Molecular basis of cell death, metabolism and autophagy in the heart and Molecular imaging of these processes in situ, using state of the art imaging technologies.
Her research explores the basic signalling mechanisms that underlie cardiovascular disease. Underpinning this, her research uses multiscale of murine and human model systems to provide a firm basis for validation and improved translational potential. Her aim is to identify novel targets for target based drug discovery, or those shared by diverse disease etiologies to utilise existing therapies in alternative indications.

PRIZES AND AWARDS


• (2014) First prize, poster at BSCR Autumn Meeting
• (2010-current) Listed in Whos Who
• (2008) Conference Reporter Bursary, British Society for Matrix Biology (BSMB), York, UK (2008, £125)
• (2006) Federation of European Connective Tissue Societies (FECTS), Oulu, Finland (2006)
• (2006) British Society for Matrix Biology (BSMB), Newcastle, UK (2006, £125)
• (2005) British Society for Matrix Biology (BSMB), Manchester, UK (2005, £125)
• (2005) International Association for Dental Research (IADR), Dundee, UK (2005, £150)
• (2005) Cardiff Institute for Tissue Engineering and Repair (CITER), Camarthan, UK (2005, £50)
• (2004) Cardiff Institute for Tissue Engineering and Repair (CITER), Swansea, UK (2004, £50)
• (2001) MAD (Made A Difference) Award, Adprotech (2001, £250)


PROFESSIONAL BODY MEMBERSHIP


• International Society for Heart Research (ISHR)
• European Society Cardiology (ESC) cellular biology of the heart and myocardial function working groups
• British Society for Cardiovascular Research (BSCR)
• Biochemical Society
• Pharmacological Society

1. Fiedler LR. Methods in Molecular Biology Series: VEGF Signaling, Editor. Springer Protocols, Humana Press, 2015: 1332.
2. Fiedler LR. Cardiovascular research:past, present and future. Heart Res Open J. 2015; 2(2): 70-81.
3. Fiedler LR, Maifoshie E, Schneider MD. Mouse Models of Heart Failure: Cell Signaling and Cell Survival. Mouse models of Developmental Genetic Disease. In: Stewart C, ed. Elsevier. 2014.
4. Stuckey DJ, McSweeney SJ, Thin MZ, et al. T1 Mapping Detects Pharmacological Retardation of Diffuse Cardiac Fibrosis in Mouse Pressure-overload Hypertrophy. CircCardiovasc Imaging. 2014; 7(2): 240-298. doi: 10.1161/CIRCIMAGING.113.000993
5. Fiedler LR, Wojciak-Stothard B. The DDAH/ADMA pathway in the control of endothelial cell migration and angiogenesis. Biochem Soc Trans. 2009; 37(6): 1243-1247.doi: 10.1042/BST0371243
6. Fiedler LR. Rac1 regulates cardiovascular development and postnatal function of endothelium. Cell Adhesion and Migration. 2009; 3(2): 143-145.
7. Fiedler LR. The DDAH/ADMA pathway is a critical regulator of NO signalling in vascular homeostasis. Cell Adhesion and Migration. 2009; 2(3): 149-150.
8. Fiedler LR, Bachetti T, Leiper J, et al. The ADMA/DDAH Pathway Regulates VEGF-mediated Angiogenesis. ArterioScler Thromb Vasc Biol. 2009; 29: 2117-2124. doi: 10.1161/ATVBAHA.109.194035
9. Fiedler LR, Eble JA. Invited Commentary: Decorin Regulates Endothelial Cell-Matrix Interactions During Angiogenesis. Cell Adhesion and Migration. 2009; 3(1): 3-6.
10. Fiedler LR, Schönherr E, Waddington R, et al. Decorin regulates endothelial cell motility on collagen I through activation of insulin-like growth factor I receptor and modulation of α2β1 integrin activity. J Biol Chem. 2008; 283(25): 17406-17415. doi: 10.1074/jbc.M710025200
11. Fiedler LR. Pharmacological agents in the clinic: trial and error. Heart Res Open J. 2015; 2(4): 126-130.doi: 10.17140/HROJ-2-122

Mazin Al Salihi, MD, PhD

Assistant Professor of Surgery (MEST)
Division of Cardiothoracic Surgery
Department of Surgery
Emory University School of Medicine
201 Dowman Drive, Atlanta
Georgia 30322, USA

BiographyResearch InterestScientific ActivitiesPublications

Prior to coming to the United States, Dr. Al Salihi was an attending cardiac surgeon at Ibn Al Bittar Cardiac Surgery in Baghdad; held several positions at the Iraqi Center for Heart Diseases, including general director; and worked as a cardiac surgeon at Al-Issra General Hospital in Amman, Jordan. Upon arriving in the states in 2008, he studied for the three steps of the United States Medical Licensing Examination (USMLE) and recertified his credentials at Kaplan Institute, Akron, Ohio. He then joined the Cleveland Clinic as a clinical associate staff surgeon while completing fellowships in cardiac surgery and heart and lung transplantation. He joins Emory as its first surgeon dedicated primarily to heart and lung procurement for transplantation. His clinical interests also include minimally invasive valve surgery and VATS thoracic surgery, and his research focus is ex vivo lung perfusion.

His research interest include: Ex vivo lung perfusion and his clinical interests include: Adult cardiac surgery; Procurement of heart and lungs for transplantation; Heart and lung transplantation, Robotically assisted mitral valve surgery, Minimally invasive valve surgery, VATS thoracic surgery

AFFLIATIONS AND SOCIETIES

Member of the Society of Thoracic Surgeons (STS)
Member of the International Society for Heart and Lung Transplantation (ISHLT)
Member of the American Medical Association (AMA)
Member of the Jordanian Medical Associations.
Member of the Iraqis Surgeons Society
Member of the Higher Consultation Commission of Iraqi Cardiac Surgery
Member of Iraqi Society of Cardio- Thoracic and Vascular
Physicians and surgeons (Treasurer)
Member of the Iraqi Medical Association

Journals and Publications

1. Hussain ST, Alsalihi M, Blackstone EH, Pettersson GB. Maximized left atrial dome approach for left atrial tumor resection. The JTCVS. 2014.
2. Svensson LG, Blackstone EH, Alsalihi M, et al. Mid-term results of David reimplantation in patients with connective tissue disorder. Annal of thoracic surgery. 2013; 95(2): 555-562. doi: 10.1016/j.athoracsur.2012.08.043.

Abass Alavi, MD, MD(Hon), PhD(Hon), DSc(Hon)

Professor of Radiology and Neurology
Director of Research Education
Department of Radiology
Perelman School of Medicine
University of Pennsylvania
HUP, 3400 SPRUCE ST
4283, Philadelphia, PA 19104, USA

BiographyResearch InterestScientific ActivitiesPublications
Education


• MD (Medicine) University of Tehran School of Medicine, (1964)


Post-Graduate Training


• Rotating Intern, Albert Einstein Medical Center, Philadelphia, PA, (1966-1967)
• First Year Resident in Medicine, Albert Einstein Medical Center, Philadelphia, PA, (1967-1968)
• Second Year Resident in Medicine, Veterans Administration Hospital, Philadelphia, PA, (1968-1969)
• Fellowship in Hematology, Hospital of the University of Pennsylvania, Philadelphia, PA, (1969-1970)
• Resident in Radiology, Beth Israel Hospital, Boston, (1970-1971)
• Fellowship, Nuclear Medicine, Hospital of the University of Pennsylvania, Philadelphia,(1971-1973)


Academic Experience


• (1982-present) Professor of Neurology, University of Pennsylvania School of Medicine, USA
• (1987-2000) Professor of Psychiatry, University of Pennsylvania School of Medicine, USA
• (1977-1982) Associate Professor of Radiology, University of Pennsylvania School of Medicine, USA


His research interests include: Nuclear medicine, Brain cancer and cardiac imaging with positron emission tomography (PET) and single photon emission computed tomography (SPECT), Treatment of cancer with radioactive compounds thyroid cancer, Lymphomas and neuro-endocrine tumors.

FELLOWSHIP


• Nuclear Medicine, Hospital of the University of Pennsylvania, (1973)


CERTIFICATIONS


• American Board of Internal Medicine, (1972)
• American Board of Radiology (Eligible), (1973)
• American Board of Nuclear Medicine, (1973)

Selected Publications


1. Alavi A. Molecular Imaging with PET, The Critical Role of PET/CT in the Management of Patients with Cancer. The Evolving Role of PET Imaging in Assessing Infection and Inflammation. Current and Future Applications of PET in Neuro-Psychiatric Disorders, PET/CT Cairo Symposium, Cairo, Egypt. 2011.
2. Alavi A. Inaugural Speaker, CV Imaging Working Group of the Penn Cardiovascular Institute. Penn CVI Cardiology/Radiology seminar series, Philadelphia, PA. 2010.
3. Alavi A. Emerging Role of Molecular Imaging with PET in the Day to Day practice of Medicine, Grand Rounds. Radiologic Society of New Jersey, Robert Wood Johnson University Hospital. University of Medicine and Dentistry of New Jersey, New Brunswick, NJ. 2010.
4. Alavi A. Emerging Role of PET and PET-CT in Assessing Musculoskeletal Disorders Biomedical Engineering Graduate Students Seminar. Department of Orthopaedic Surgery & Rehabilitation Medicine, SUNY Downstate Medical Center, Brooklyn, New York. 2010.
5. Alavi A. Panel Member, Scientific Review Panel, R 21 applications, Clinical Studies of Bisphosphonate Therapy and Osteonecrosis of the Jaw (R21). National Institute of Dental and Craniofacial Research, Teleconference. 2010.
6. Alavi A. Emerging Role of Hybrid Imaging for Optimal Assessment of Molecular Alterations in Neuropsychiatric Disorders and Its Implications for Individualized Treatments in the Future. American Society of Functional Neuroradiology, Vic Haughton Honorary Lecture, Wynn Encore, Las Vegas. 2010.
7. Alavi A. Molecular Imaging with PET, A Revolution in Medicine, Clinical Applications of PET in Lymphoma and Pediatrics, Emerging Role of PET in Assessing and monitoring Patients with Suspected and Proven infection and inflammation, Critical Role of PET in the Management of patients with Central Nervous System Disorders Nuclear Medicine Section. Department of Medical Imaging, King Fahad Hospital, Riyadh, Kingdom of Saudi Arabia. 2010.
8. Alavi A. Emerging Role of PET and PET-CT in the Day to Day Practice of Medicine, Grand Rounds. Depart. of Internal Medicine, Cleveland Clinic, Cleveland, OH. 2010.
9. Alavi A. Novel Quantitative Techniques for Defining Tumor Biology; a New Paradigm in Cancer Research. Department of Nuclear Medicine Research Conference. Cleveland Clinic Taussig Cancer Center. Cleveland, OH. 2010.
10. Alavi A. FDG-PET: A brief history to current perspectives in oncologic imaging, Grand Rounds, Department of Nuclear Medicine, Cleveland Clinic Taussig Cancer Center. Cleveland, OH. 2010.
11. Alavi A. Scientific Review Panel, Nutrition Obesity Research Centers (P30) applications, National Institute of Diabetes and Digestive and Kidney Diseases. National Institutes of Health. Washington, DC. 2010.
12. Alavi A. Member, Scientific Review Panel, Nanotechnology R25T and K99/R00 Applications for National Cancer Institute. National Institutes of Health, Rockville, MD. 2010.
13. Alavi A. Revolutionary Impact of Molecular Imaging with PET on Research and the Day to Day Practice of Medicine, Dermatology Research Seminar Series, Department of Dermatology School of Medicine. University of Pennsylvania, Phila, PA. 2010.
14. Alavi A. F-Fluorodeoxyglucose-Positron Emission Tomography for the detection of infections and aseptic inflammatory disorders, CASE Seminars of the Food and Drug Administration, Division of Antimicrobial and Ophthalmology Products. Center for Drug Evaluation and Research. FDA White Oak campus. Silver Springs, MD. 2010.
15. Alavi A. Medical Education Program. Genzyme, Inc. Cambridge, MA. 2010.
16. Alavi A. Application of Biomarkers and Imaging to Early Phase Studies with an Anti-LOXL2 Antibody. Arresto BioSciences. Palo Alto, CA. 2010.

Muthiah Vaduganathan, MD, MPH

Department of Medicine
Massachusetts General Hospital
Boston, MA 02114, USA

BiographyResearch InterestScientific ActivitiesPublications

Dr. Vaduganathan is a resident in Internal Medicine at Massachusetts General Hospital in Boston, MA, USA. He received his medical degrees from Northwestern University, Feinberg School of Medicine in 2012. His public health thesis work focused on perioperative management approaches in patients undergoing major cardiovascular surgeries. He has authored or co-authored more than 80 peer-reviewed publications in journals including the Journal of the American Medical Association, Journal of the American College of Cardiology, and Circulation: Heart Failure.

His research interests include: Identifying strategies to ameliorate post-discharge outcomes in patients hospitalized for heart failure and the development and testing of new-generation anti platelet therapies for patients with coronary artery disease.

HONORS/AWARDS

• 2014 Journal of American College of Cardiology: Heart Failure Fellow - Selected by the Editorial Board of JACC HF to facilitate early career development and participate in a broad spectrum of Journal activities.


PROFESSIONAL MEMBERSHIPS

• 2014 - present Society of General Internal Medicine (SGIM)
• 2014 - present American College of Physicians (ACP)
• 2012 - present Massachusetts Medical Society (MMS)
• 2008 - 2012 American Medical Association (AMA)
• 2008 - 2012 Illinois State Medical Society (ISMS)
• 2008 - 2012 Chicago Medical Society (CMS)
• 2008 - 2012 Indian American Medical Association (IAMA)
• 2008 American Heart Association

Peer-Reviewed Original Articles

1. Vaduganathan M, Greene SJ, Ambrosy AP, et al. Relation of serum uric acid levels and outcomes among patients hospitalized for worsening heart failure with reduced ejection fraction (from the EVEREST trial). Am J Cardiol. 2014; S0002-9149(14): 01783-01784 doi: 10.1016/j.amjcard.2014.09.008.
2. Vaduganathan M, Kornowski R, Vaknin-Assa H, et al. Coronary stenting approaches in the treatment of chronic total occlusion: Contemporary registry-based experience. J Cardiovasc Med (Hagerstown) . 2014. doi:
3. Perl L, Zemer-Wassercug N, Rechavia E, et al. Comparison of platelet inhibition by prasugrel versus ticagrelor over time in patients with acute myocardial infarction. J Thromb Thrombolysis. 2014. doi: 10.1007/s11239-014-1119-9
4. Vaduganathan M, Dei Cas A, Mentz RJ, et al. Mineralocorticoid receptor antagonist use in hospitalized patients with heart failure, reduced ejection fraction, and diabetes mellitus (from the EVEREST trial). Am J Cardiol. 2014. doi: 10.1016/j.amjcard.2014.05.064
5. Mentz RJ, Greene SJ, Ambrosy AP, et al. Clinical profile and prognostic value of anemia at the time of admission and discharge among patients hospitalized for heart failure with reduced ejection fraction: Findings from the EVEREST trial. Circ Heart Fail. 2014; 7(3): 401-408. doi: 10.1161/CIRCHEARTFAILURE.113.000840.
6. Levi A, Korowski R, Vaduganathan M, et al. Incidence, predictors and outcomes of failed primary percutaneous coronary intervention: A 10-year contemporary experience. Coron Artery Dis. 2014; 25(2): 145-151. doi: 10.1097/MCA.0000000000000065.
7. Perl L, Lerman-Shivek H, Rechavia E, et al. Response to prasugrel and levels of circulating reticulated platelets in patients with ST-elevation myocardial infarction. J Am Coll Cardiol. 2014; 63(6): 513-517. doi: 10.1016/j.jacc.2013.07.110.
8. Greene SJ, Vaduganathan M, Wilcox J, et al. The prognostic significance of heart rate in patients hospitalized for heart failure with reduced ejection fraction in sinus rhythm: Insights from the EVEREST trial. JACC Heart Fail. 2013; 1(6): 488-496 doi: 10.1016/j.jchf.2013.08.005
9. Vaduganathan M, Greene SJ, Ambrosy AP, et al. Relation of serum magnesium levels and postdischarge outcomes in patients hospitalized for heart failure (from the EVEREST trial). Am J Cardiol. 2013; 112(11): 1763-1769. doi: 10.1016/j.amjcard.2013.07.020.
10. Greene SJ, Gheorghiade M, Vaduganathan M, et al. Hemoconcentration, renal function, and post-discharge outcomes among patients hospitalized for heart failure with reduced ejection fraction: Insights from the EVEREST trial. Eur J Heart Fail. 2013; 15(12): 1401-1411. doi:
11. Lev EI, Singer J, Leshem-Lev D, Rigler M, et al. Effect of intensive glycemic control on endothelial progenitor cells in patients with long-standing uncontrolled type 2 diabetes. Eur J Prev Cardiol. 2013. doi: 10.1177/2047487313488300.
12. Eisen A, Kornowski R, Vaduganathan M, et al. Retroperitoneal bleeding after cardiac catheterization: A 7-year descriptive single center experience. Cardiology. 2013; 125(4): 217-222. doi: 10.1159/000351090.
13. Vaturi M, Vaduganathan M, Bental T, Solodky A, Kornowski R, Lev EI. Relation of aspirin response to age in patients with stable coronary artery disease. Am J Cardiol. 2013; 112(2): 212-216. doi: 10.1016/j.amjcard.2013.03.022.
14. Ambrosy AP, Gheorghiade M, Bubenek S, et al. The predictive value of transaminases at admission in patients hospitalized for heart failure: Findings from the RO-AHFS registry. Eur Heart J Acute Cardiovasc Care. 2013; 2(2): 99-108. doi: 10.1177/2048872612474906.
15. Ambrosy AP, Vaduganathan M, Mentz RJ, et al. Clinical profile and prognostic value of low systolic blood pressure in patients hospitalized for heart failure with reduced ejection fraction: Insights from the EVEREST trial. Am Heart J. 2013; 165(2): 216-225. doi: 10.1016/j.ahj.2012.11.004.
16. Greene SJ, Vaduganathan M, Lupi L, et al. Prognostic significance of serum total cholesterol and triglyceride levels in patients hospitalized for heart failure with reduced ejection fraction (from the EVEREST trial). Am J Cardiol. 2013; 111(4): 574-581. doi: 10.1016/j.amjcard.2012.10.042.
17. Butler J, Subacius H, Vaduganathan M, et al. Relationship between clinical trial site enrollment with participant characteristics, protocol completion and outcomes: Insights from the EVEREST trial. J Am Coll Cardiol. 2013; 61(5): 571-579. doi: 10.1016/j.jacc.2012.10.025.
18. Mentz RJ, Chung MJ, Gheorghiade M, et al. Atrial fibrillation or flutter on initial EKG is associated with worse outcomes in patients admitted for worsening heart failure with reduced ejection fraction: Findings from the EVEREST trial. Am Heart J. 2012; 164(6): 884-892.e2. doi: 10.1016/j.ahj.2012.09.011.
19. Vaduganathan M, Ambrosy AP, Greene SJ, et al. The predictive value of low relative lymphocyte count in patients hospitalized for heart failure with reduced ejection fraction: Insights from the EVEREST trial. Circ Heart Fail. 2012; 5(6): 750-758. doi: 10.1161/CIRCHEARTFAILURE.112.970525.
20. Vaduganathan M, Lee R, Beckham A, et al. Relation of body mass index to late survival after valvular heart surgery. Am J Cardiol. 2012; 110(11): 1667-1678. doi: 10.1016/j.amjcard.2012.07.041
21. Greene SJ, Harinstein ME, Vaduganathan M, et al. Prognostic value of monocyte count in patients hospitalized for heart failure with reduced ejection fraction (from the EVEREST) trial. Am J Cardiol. 2012; 110(11): 1657-1662. doi: 10.1016/j.amjcard.2012.07.035.
22. Mentz RJ, Allen BD, Kwasny MJ, et al. Influence of documented history of coronary artery disease on outcomes in patients admitted for worsening heart failure with reduced ejection fraction in the EVEREST trial. Eur J Heart Fail. 2013; 15(1): 61-68. doi: 10.1093/eurjhf/hfs139.
23. Vaduganathan M, Gheorghiade M, Pang PS, et al. Efficacy of oral tolvaptan in acute heart failure patients with hypotension and renal impairment. J Cardiovasc Med (Hagerstown) . 2012; 13(7): 415-422. doi: 10.2459/JCM.0b013e328355a740.
24. Vaduganathan M, Stone NJ, Andrei AC, et al. Midterm benefits of preoperative statin therapy in patients undergoing isolated valvular heart surgery: a propensity-matched analysis of a 6-year surgical experience. Ann Thorac Surg. 2012; 93(6): 1881-1887. doi:
25. Codner P, Vaduganathan M, Rechavia E, et al. Clopidogrel response up to six months after acute myocardial infarction. Am J Cardiol. 2012; 110(3): 321-325. doi: 10.1016/j.amjcard.2012.03.029.
26. Lee R, McCarthy PM, Wang EC, et al. Midterm survival in patients treated for atrial fibrillation: A propensity-matched comparison to patients without a history of atrial fibrillation. J Thorac Cardiovasc Surg. 2012; 143(6): 1341-1351. doi: 10.1016/j.jtcvs.2012.02.006.
27. Assali A, Vaduganathan M, Vaknin-Assa H, et al. Comparison of late (3-year) registry data outcomes using bare metal versus drug-eluting stents for treating ST-segment elevation myocardial infarctions. Am J Cardiol. 2012; 109(11): 1563-1568. doi: 10.1016/j.amjcard.2012.01.378.
28. Ambrosy A, Vaduganathan M, Huffman MD, et al. Clinical course and predictive value of liver function tests in patients hospitalized for worsening heart failure with reduced ejection fraction: an analysis of the EVEREST trial. Eur J Heart Fail. 2012; 14(3): 302-311. doi: 10.1093/eurjhf/hfs007.
29. Yedidya I, Netzer A, Vaduganathan M, Solodky, Kornowski R, Lev EI. Clopidogrel tapering as a strategy to attenuate platelet rebound phenomenon in patients with bare-metal stents. J Thromb Thrombolysis. 2012; 33(1): 16-21. doi: 10.1007/s11239-011-0652-z.
30. Vaduganathan M, Stone NJ, Lee R, et al. Perioperative statin therapy reduces mortality in normolipidemic patients undergoing cardiac surgery. J Thorac Cardiovasc Surg. 2010; 140(5): 1018-1027. doi: 10.1016/j.jtcvs.2010.08.002.
31. Mangalpally KK, Siqueiros-Garcia A, Vaduganathan M, Dong JF, Kleiman NS, Guthikonda S. Platelet activation patterns in platelet size sub-populations: differential response to aspirin in vitro. J Thromb Thrombolysis. 2010; 30(3): 251-262. doi: 10.1007/s11239-010-0489-x.
32. Ling SM, Patel DD, Garnero P, et al. Serum protein signatures detect early radiographic osteoarthritis. Osteoarthritis Cartilage. 2009; 17(1): 43-48. doi: 10.1016/j.joca.2008.05.004.
33. Vaduganathan M, Alviar CL, Arikan M, et al. Platelet reactivity and response to aspirin in subjects with the metabolic syndrome. Am Heart J. 2008; 156(5): 1002.e1-e7. doi: 10.1016/j.ahj.2008.08.002.
34. Guthikonda S, Alviar CL, Vaduganathan M, et al. Role of reticulated platelets and platelet size heterogeneity on platelet activity after dual antiplatelet therapy with aspirin and clopidogrel in patients with stable coronary artery disease. J Am Coll Cardiol. 2008; 52(9): 743-749. doi: 10.1016/j.jacc.2008.05.031.
35. Guthikonda S, Mangalpally K, Vaduganathan M, et al. Increased platelet sensitivity among individuals with aspirin resistance – platelet aggregation to submaximal concentrations of arachidonic acid predicts response to antiplatelet therapy. Thromb Haemost. 2008; 100(1): 83-89. doi: 10.1160/TH07-10-0590.
36. Lev EI, Arikan ME, Vaduganathan M, et al. Effect of caffeine on platelet inhibition by clopidogrel in healthy subjects and patients with coronary artery disease. Am Heart J. 2007; 154 (4): 694.e1-e7. doi: http://dx.doi.org/10.1016/j.ahj.2007.07.014
37. Lev EI, Ramchandani M, Garg R, et al. Response to aspirin and clopidogrel in patients scheduled to undergo cardiovascular surgery. J Thromb Thrombolysis. 2007; 24(1): 15-21. doi: 10.1007/s11239-007-0008-x
38. Patel RT, Lev EI, Vaduganathan M, et al. Platelet reactivity among Asian Indians and Caucasians. Platelets. 2007; 18(4): 261-265. doi: 10.1080/09537100701235716

Arman Qamar, MD

Cardiovascular Division
Department of Medicine
Brigham and Womens Hospital
Harvard Medical School
75 Francis Street, Boston, MA 02115, USA

BiographyResearch InterestScientific ActivitiesPublications

Dr. Qamar is a fellow at the cardiovascular division, at Brigham and Womens Hospital of the Harvard Medical School in Boston, USA. He completed his internal medicine residency at the Hospital of the University of Pennsylvania in Philadelphia where he was awarded the Maurice F. Attie senior and junior resident teaching award for excellence in medical education and the Frederick F. Samaha award for excellence in cardiovascular research.

His research interests include: Identifying novel circulating biomarkers of atherosclerosis and acute coronary syndromes. He was investigating the role of these biomarkers in early detection, prognostication and development of novel therapeutics in patients with atherosclerotic cardiovascular disease.

Professional Societies

• 2011-present American Heart Association
• 2011-present Council on Arteriosclerosis, Thrombosis and Vascular Biology


Honors and Awards

• 2005 KS Award, University of Delhi, Awarded for academic excellence in Anatomy
• 2005 KS Award, University of Delhi, Awarded for academic excellence in Physiology
• 2005 Merit Medal, University of Delhi, Awarded for academic excellence in Microbiology
• 2005 Merit Medal, University of Delhi, Awarded for academic excellence in Biochemistry
• 2008 Faculty of Pathology Golden Jubilee of Independence Award, University of Delhi Awarded for academic excellence in Pathology
• 2008 KL Award, University of Delhi, Awarded for academic excellence in Pharmacology • 2009 LVP Medal, University of Delhi, Awarded for outstanding grades in obstetrics and gynaecology clerkship
• 2010 Deans Gold Medal, University of Delhi, Awarded in recognition of highest grades in medical school & core clerkships
• 2010 Delhi Medical Association Gold Medal, University of Delhi, Awarded to the top graduating medical student
• 2010 Medical School Alumni Award, University of Delhi, Awarded for excellence in academics
• 2010 Memorial Gold Medal, University of Delhi, Awarded in recognition of highest grades in Internal Medicine
• 2010 MS Award & CB Gold Medal, University of Delhi, awarded in recognition of highest grades in Internal Medicine
• 2010 SR Gold Medal, University of Delhi, Awarded in recognition of highest grades in surgery clinical clerkship
• 2010 Dr A. M. Memorial Award, University of Delhi, Awarded in recognition of academic excellence in the fourth year of medical school
• 2010 LHSJ Memorial Medal, University of Delhi, Awarded in recognition of academic excellence in the fourth year of medical school
• 2010 RV Gold Medal, University of Delhi, Awarded in recognition of academic excellence in medical school
• 2010 Dr KKSM Gold Medal, University of Delhi, Awarded in recognition of academic excellence in medical school
• 2010 S Vishwanathan Prize, University of Delhi, Awarded for outstanding grades in the obstetrics and gynaecology clerkship
• 2010 PCC Memorial Prize, University of Delhi, Awarded for academic excellence in medical school
• 2013 The Maurice F. Attie Junior Resident Teaching Award, Department of Medicine, Perelman School of Medicine, University of Pennsylvania
• 2013 Frederick F. Samaha Award for Resident Scholarship, Department of Medicine, Perelman School of Medicine, University of Pennsylvania
• 2014 The Maurice F. Attie Senior Resident Teaching Award, Department of Medicine, Perelman School of Medicine, University of Pennsylvania

Peer reviewed publications

1. Mehta N, Qamar A, Qu L, et al. Differential association of plasma angiopoietin-like proteins 3 and 4 with lipid and metabolic traits. Arterioscler Thromb Vasc Biol. 2014; 34(5):1057-1063. doi: 10.1161/ATVBAHA.113.302802.
2. Usman MH, Qamar A, Gadi R, et al. Extended-Release Niacin Acutely Suppresses Postprandial Triglyceridemia. American Journal of Medicine. 2012; 125(10): 1026-1035. doi: 10.1016/j.amjmed.2012.03.017.


Other peer-reviewed publications

1. Qamar A, Ioannides KL, Khetarpal S, Kiss D. Bilateral Earlobe Creases and Severe Coronary Artery Disease. Circulation. 2014; 130(1): 92-93.
2. Qamar A, Rader DJ. Effect of Interleukin 1 Beta Inhibition in Cardiovascular Disease. Current Opinion in Lipidology. 2012; 23(6): 548-553. doi: 10.1097/MOL.0b013e328359b0a6.
3. Aggarwal S, Qamar A, Sharma V, Sharma A. Abdominal Aortic Aneurysm: A Comprehensive Review. Experimental and Clinical Cardiology. 2011; 16(1): 11-15.
4. Arman Q. Angiotensin converting enzyme gene polymorphism and influence of ACE inhibition. Indian J Nephrol. 2010; 20(4): 223. doi: 10.4103/0971-4065.73433

Şevket Balta, MD

Faculty
Gulhane School of Medicine
Tevfik Saglam St
06018 Etlik-Ankara, Turkey

BiographyResearch InterestScientific ActivitiesPublications

Sevket Balta has completed his MD at the age of 31 years from Akdeniz University and postdoctoral studies from Gulhane Medical Faculty, School of Medicine. He is MD of Gulhane Medical Faculty. He has published more than 450 papers in reputed journals and has been serving as an editorial board member of some journals. Also, he has been serving as reviewer for more than 50 journals. His research and clinical work focuses on inflammatory diseases, inflammatory markers hypertension and acute coronary artery diseases.

His research and clinical work focuses on inflammatory diseases, inflammatory markers hypertension and acute coronary artery diseases.

1. Balta S, Ozturk C, Demirkol S, Demir M, Yildirim AO, Celik T. Vitamin D Levels in Patients with Atrial Fibrillation. Ann Noninvasive Electrocardiol. 2016.
2. Balta S, Ozturk C, Demir M, Yildirim AO. Apelin Levels in Patients with Coronary Artery Ectasia. Korean Circ J. 2016; 46(3): 431. doi: 10.4070/kcj.2016.46.3.431
3. Celik T, Ozturk C, Balta S, Yilmaz MI. Nebivolol and Endothelial Dysfunction in Patients With Essential Hypertension: A Reputation Saver of β-Blockers? J Clin Hypertens (Greenwich). 2016. doi: 10.1111/jch.12856
4. Balta S, Ozturk C, Yildirim AO, Erdogan S, Celik T. The neutrophil-lymphocyte ratio and atherosclerosis. Expert Rev Cardiovasc Ther. 2016. doi: 10.1080/14779072.2016.1194199
5. Öztürk C, Çelik T, Balta Ş, İyisoy A. Do spontaneous coronary artery dissections always need intervention in patients with no atherosclerosis? Anatol J Cardiol. 2016; 16(5): 365-366. doi: 10.14744/AnatolJCardiol.2016.7120
6. Balta S, Celik T, Ozturk C, et al. The relation between monocyte to HDL ratio and no-reflow phenomenon in the patients with acute ST-segment elevation myocardial infarction. Am J Emerg Med. 2016. doi: 10.1016/j.ajem.2016.05.031
7. Balta S, Alemdar R, Erdogan S, Demir M, Ozturk C, Celik T. Ischemia modified albumin in cardiovascular disease. Am J Emerg Med. 2016. doi: 10.1016/j.ajem.2016.05.030
8. Balta S, Aparci M, Ozturk C, Demir M, Yildirim AO, Celik T. Mean platelet volume as one part of platelet function determining inflammation. Ann Saudi Med. 2016; 36(3): 234. doi: 10.5144/0256-4947.2016.234
9. Ozturk C, Celik T, Iyisoy A, et al. Percutaneous transapical closure of cardiac apex and mitral prosthetic paravalvular leak is feasible and alternative approach to the septal approach. Gen Thorac Cardiovasc Surg. 2016. doi: 10.4172/2161-1076.1000262
10. Celik T, Ozturk C, Balta S, Demirkol S, Iyisoy A. Coronary microvascular dysfunction in patients with cardiac syndrome X: Ongoing debate. Int J Cardiol. 2016; 218: 233-234. doi: 10.1016/j.ijcard.2016.05.050
11. Celik T, Balta S, Ozturk C, Iyisoy A. Whole Blood Viscosity and Cardiovascular Diseases: A Forgotten Old Player of the Game. Med Princ Pract. 2016. doi: 10.1159/000446916
12. Uslu AU, Yonem O, Aydin B, et al. Red cell distribution width is associated with albuminuria in adults with familial Mediterranean fever. Kaohsiung J Med Sci. 2016; 32(4): 216-220. doi: 10.1016/j.kjms.2016.03.009
13. Ozturk C, Ozturk A, Balta S, et al. Direction of aortic jet flow is important in predicting aortic dilatation in patients with bicuspid aortic valve. Kardiol Pol. 2016; 74(2):196. doi: 10.5603/KP.2016.0025
14. Balta S, Balta I, Ozturk C, Celik T, Iyisoy A. Behçets disease and risk of vascular events. Curr Opin Cardiol. 2016; 31(4): 451-457. doi: 10.1097/HCO.0000000000000281
15. Celik T, Ozturk C, Balta S, Erdogan S, Rreka A, Iyisoy A. Sodium bicarbonate dilemma in patients with out-of-hospital cardiac arrest: A double-edged sword. Am J Emerg Med. 2016. doi: 10.1016/j.ajem.2016.04.038
16. Celik T, Ozturk C, Balta S, Iyisoy A. The role of combined electrocardiogram criteria in differential diagnosis of acute pericarditis: PR segment and QT interval. Am J Emerg Med. 2016. doi: 10.1016/j.ajem.2016.04.013
(http://www.ajemjournal.com/article/S0735-6757(16)30037-7/abstract?cc=y=) 17. Celık T, Balta S, Kaya MG, Ozturk C, Demırkol S, Iyısoy A. The effectiveness of bilirubin for the treatment of ischemia-reperfusion injury in an experimental model: Can it be extrapolated to humans? Int J Cardiol. 2016; 215: 173-174. doi: 10.1016/j.ijcard.2016.04.146
18. Ozturk C, Celik T, Iyisoy A, et al. Acute anterior myocardial infarction after heavy exercise in a young sportsman: Importance of intravascular ultrasonography on differential diagnosis. Int J Cardiol. 2016; 215: 169-172. doi: 10.1016/j.ijcard.2016.04.041
19. Uslu AU, Aydin B, Icagasıoğlu IS, et al. The Relationship among the Level of Serum Amyloid A, High-Density Lipoprotein and Microalbuminuria in Patients with Familial Mediterranean fever. J Clin Lab Anal. 2016. doi: 10.1002/jcla.21971
20. Celık T, Balta S, Ozturk C, Yıldırım AO, Iyısoy A. The best treatment option in the management of patients with acute massive pulmonary embolism: surgery or thrombolysis? Int J Cardiol. 2016; 214: 286-287. doi: 10.1016/j.ijcard.2016.03.141
21. Celik T, Ozturk C, Balta S, Iyisoy A. The best treatment option in the management of patients with chronic total occlusion of a single coronary artery: Debate continues. Int J Cardiol. 2016; 214: 79-80. doi: 10.1016/j.ijcard.2016.03.145
22. Celik T, Balta S, Ozturk C, Yildirim AO, Iyisoy A. Qrs prolongation and long-term prognosis in patients with dilated cardiomyopathy: Reflections from diphteritic myocarditis. Int J Cardiol. 2016; 212: 295. doi: 10.1016/j.ijcard.2016.03.092
23. Ozturk C, Balta S, Demir M, et al. The relation between coronary artery ectasia and psychological-environmental factors. J Saudi Heart Assoc. 2016; 28(2): 127-128. doi: 10.1016/j.jsha.2015.12.008
24. Uslu AU, Kucuk A, Balta S, et al. The relation between ischemia modified albumin levels and carotid intima media thickness in patients with rheumatoid arthritis. Int J Rheum Dis. 2016. doi: 10.1111/1756-185X.12851
25. Balta S, Yildirim AO, Ozturk C. Red Cell Distribution Width and Coronary Artery Calcification. Korean Circ J. 2016; 46(2): 270-272. doi: 10.4070/kcj.2016.46.2.270
26. Balta S, Demirkol S, Ozturk C, Yildirim AO, Demir M, Celik T. The Relation Between Endocan Levels and Subclinic Atherosclerosis. Clin Appl Thromb Hemost. 2016. doi: 10.1177/1076029616639701
27. Celik T, Bozlar U, Ozturk C, et al. A new anomaly of the left anterior descending artery: Type X dual LAD. Indian Heart J. 2015; 67(3): S14-S17. doi: 10.1016/j.ihj.2015.09.004
28. Celik T, Balta S, Ozturk C, Unlu M, Iyisoy A. Platelet Indices in Patients With Acute Coronary Syndromes: A Bedside Marker of Prognosis? Angiology. 2016. doi: 10.1177/0003319716638796
29. Balta S, Demır M, Yıldırım AO, Demırkol S, Ozturk C, Celık T. Epicardial fat thickness and cardiovascular involvements. Afr Health Sci. 2015; 15(4): 1354-1355. doi: 10.4314/ahs.v15i4.40
30. Ozturk C, Yildirim AO, Demir M, Balta S. Coronary Obstruction During Transcatheter Aortic Valve Replacement: Related to Calcification or Thrombus? Rev Esp Cardiol (Engl Ed). 2016; 69(4): 456-457. doi: 10.1016/j.rec.2015.12.012
31. Celık T, Ozturk C, Balta S, Demırkol S, Iyısoy A. A new route to life in patients with circulatory shock: intraosseous route. Am J Emerg Med. 2016; 34(5): 922-923. doi: 10.1016/j.ajem.2016.02.035
32. Icli A, Cure E, Cumhur Cure M, et al. Novel myokine: irisin may be an independent predictor for subclinic atherosclerosis in Behçets disease. J Investig Med. 2016; 64(4): 875-881. doi: 10.1136/jim-2015-000044
33. Celik T, Balta S, Ozturk C, Iyisoy A. Survival of the young patients with acute ST segment elevation myocardial infarction treated with primary percutaneous coronary intervention: Does gender matters? Int J Cardiol. 2016; 210: 54-55. doi: 10.1016/j.ijcard.2016.02.107
34. Celik T, Yilmaz MI, Balta S, et al. The Relationship Between Plasma Whole Blood Viscosity and Cardiovascular Events in Patients With Chronic Kidney Disease. Clin Appl Thromb Hemost. 2016. doi: 10.1177/1076029616634888
35. Ozturk C, Celik T, Ozturk A, Balta S, Iyisoy A. Duration of antiplatelet or anticoagulant therapy after transcatheter aortic valve implantation in high risk patients; longer or shorter. Int J Cardiol. 2016; 210: 14-15. doi: 10.1016/j.ijcard.2016.02.111
36. Balta S, Ozturk C, Aparci M, Demir M, Yildirim AO, Çelik T. Red cell distribution width in patients with intermediate coronary artery disease. Med Princ Pract. 2016. doi: 10.1159/000444800
37. Ozturk C, Iyisoy A, Onrat E, Balta S, Celik T. The more proximal implantation of percutaneous mitral annuloplasty device due to the circumflex artery compression may be less beneficial. Int J Cardiol. 2016; 209: 46-48. doi: 10.1016/j.ijcard.2016.02.051
38. Iyisoy A, Ozturk C, Celik T, et al. Percutaneous closure of ventricular septal defect with membraneous pouch and changing the device due to severe aortic regurgitation. Int J Cardiol. 2016; 209: 42-45. doi: 10.1016/j.ijcard.2016.02.044
39. Ozturk C, Ozturk A, Demir M, et al. Blood Pressure Variability Provides Useful and Prognostic Information on the White-Coat Effect Among Older Patients. J Clin Hypertens (Greenwich). 2016. doi: 10.1111/jch.12796
40. Ozturk C, Haqmal H, Balta S, et al. The association of severe aortic stenosis and narrow aortic root in a young patient - What is the etiology: Rheumatic valvulitis or Lambls excrescences? Int J Cardiol. 2016; 208: 87-91. doi: 10.1016/j.ijcard.2016.01.018
41. Balta S, Aparci M, Demir M, Yildirim AO, Ozturk C, Celik T. The relation between signal peptide-CUB-EGF domain-containing protein 1 and coronary artery disease. Am J Emerg Med. 2015. doi: 10.1016/j.ajem.2015.11.056
42. Ozturk C, Iyisoy A, Gursoy E, et al. The successful management of early rupture of abdominal aorticaneurysm with endovascular stenting and instent stenting for endoleak following EVAR; a case report. Int J Cardiol. 2016; 207: 152-156. doi: 10.1016/j.ijcard.2016.01.151
43. Kucuk U, Kucuk HO, Balta S, Aparci M. eComment. Rise of Ticagrelor and the vital necessity for specific reversal agents. Interact Cardiovasc Thorac Surg. 2016; 22(2): 410. doi: 10.1093/icvts/ivv351
44. Kucuk U, Kucuk HO, Balta S, Demirkol S. Important role of shivering suppression during therapeutic hypothermia. Eur Rev Med Pharmacol Sci. 2015; 19(24): 4689. Web site. http://www.europeanreview.org/article/10010. Accessed
45. Ozturk C, Iyisoy A, Sahin MA, et al. Left subclavian artery dissection and repair after transcatheter aortic valve implantation; the diameter of the axillary artery is important for axillary intervention. Int J Cardiol. 2016; 204: 77-80. doi: 10.1016/j.ijcard.2015.11.159
46. Akın A, Ozturk C, Aparci M, et al. Age and Aortic Diameters in Pilots. Mil Med. 2015; 180(12): 1262-1267. doi: 10.7205/MILMED-D-14-00703
47. Kucuk HO, Eyuboglu M, Kucuk U, Balta S. Occupational exposure to hand-arm vibration. Int J Cardiol. 2015; 203: 959.
48. Demirkol S, Ozturk C, Balta S, Unlu M, Arslan Z. Subclinical Left Ventricular Dysfunction in Patients with Obstructive Sleep Apnea. Med Princ Pract. 2016; 25(3): 299-300. doi: 10.1159/000442881
49. Icli A, Cure E, Cure MC, et al. Endocan Levels and Subclinical Atherosclerosis in Patients With Systemic Lupus Erythematosus. Angiology. 2015 Nov 26. pii: 0003319715616240. [Epub ahead of print] PubMed PMID: 26614790. 50. Ozturk C, Iyisoy A, Celik T, et al. Long distance walking man after a combination of percutaneous mitral annuloplasty and coronary revascularization. Int J Cardiol. 2015. doi: 10.1016/j.ijcard.2015.10.015
51. Ozturk C, Unlu M, Yildirim AO, et al. The progressed atrioventricular block associated with ticagrelor therapy may not require permanent pacemaker after acute coronary syndrome; it may be reversible. Int J Cardiol. 2015; 203: 822-824. doi: 10.1016/j.ijcard.2015.11.042
52. Aydogan M, Balta S, Demirkol S, Gumus S. The Pivotal Roles of Risk Factors for Acute Respiratory Distress Syndrome. J Emerg Med. 2015. doi: 10.1016/j.jemermed.2013.08.156
53. Balta S, Aparci M, Ozturk C, Yildirim AO, Demir M, Celik T. Carotid intima media thickness and subclinical early atherosclerosis. Int J Cardiol. 2015. doi: 10.1016/j.ijcard.2015.11.025
54. Balta S, Demir M, Kucuk U, Ozturk C, Yildirim AO, Celik T. Arterial Stiffness: Good Predictor for Hypertensive Patients. J Clin Hypertens (Greenwich). 2015. doi: 10.1111/jch.12740
55. Balta S, Aparci M, Yildirim AO, Demir M, Ozturk C, Celik T. The relation between flow mediated dilation and atrial fibrillation. Int J Cardiol. 2015. doi: 10.1016/j.ijcard.2015.07.033
56. Ozturk C, Yildirim AO, Demir M, et al. The spontaneous coronary artery dissection may need intervention in the proximal segment of the arteries. Int J Cardiol. 2016; 202: 943-944. doi: 10.1016/j.ijcard.2015.09.084
57. Balta S, Demirkol S, Aparci M, Yildirim AO, Ozturk C, Celik T. Red blood cell distribution width: Just one of many things to consider. Int J Cardiol. 2015; 203: 438-439. doi: 10.1016/j.ijcard.2015.10.097
58. Ozturk C, Yildirim AO, Demir M, et al. The spontaneous coronary artery dissection may need intervention in the proximal segment of the arteries. Int J Cardiol. 2015. doi: 10.1016/j.ijcard.2015.09.084
59. Balta S, Ozturk C, Balta I, et al. The Neutrophil-Lymphocyte Ratio and Inflammation. Angiology. 2015. doi: 10.1177/0003319715615252
60. Iyisoy A, Ozturk C, Celik T, et al. The combination of percutaneous transapical and transseptal closure of cardiac apex and prosthetic mitral paravalvular leak with loop technique. Int J Cardiol. 2015; 203: 221-224. doi: 10.1016/j.ijcard.2015.10.132
61. Demirkol S, Ozturk C, Balta S, Celik T, Iyisoy A. Utility of Isovolumic Contraction Peak Velocity for Evaluation of Adult Patient Status after Transcatheter Closure of Atrial Septal Defect. Echocardiography. 2015; 32(11): 1742. doi: 10.1111/echo.13037
62. Celık T, Balta S, Demır M, et al. Predictive value of admission red cell distribution width-platelet ratio for no-reflow phenomenon in acute ST segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. Cardiol J. 2015. doi: 10.5603/CJ.a2015.0070
63. Cakmak T, Metin S, Balta S, Sen A, Akin A. The Use of Hyperbaric Oxygen Therapy in Dentistry. J Clin Diagn Res. 2015; 9(9): ZL01.
64. Ünlü M, Demirkol S, Yildirim AO, Balta Ş, Öztürk C, Iyisoy A. Atrioventricular block associated with ticagrelor therapy may require permanent pacemaker. Int J Cardiol. 2015. doi: 10.1016/j.ijcard.2015.08.067
65. Aparci M, Ozturk C, Celik T, et al. Can a novel scoring system derived from hemodynamic and anthropometric variables predict sympathetic drive in young patients? Blood Press Monit. 2015. doi: 10.1097/MBP.0000000000000152
66. Balta S, Mikhailidis DP, Demirkol S, Ozturk C, Celik T, Iyisoy A. Endocan: A novel inflammatory indicator in cardiovascular disease? Atherosclerosis. 2015; 243(1): 339-343. doi:10.1016/j.atherosclerosis.2015.09.030
67. Balta S, Ozturk C, Yildirim AO, Aparci M, Demir M, Celik T. The Relation Between Neutrophil-Lymphocyte Ratio and Hypertension. Am J Hypertens. 2015; 28(11): 1386. doi: 10.1093/ajh/hpv137
68. Ünlü M, Balta S, Yildirim AO, Ozturk C, Demir M, Celik T. The Neutrophil-to-Lymphocyte Ratio Is Valuable at All Stages of Coronary Artery Disease. Cardiology. 2016; 133(1): 56. doi: 10.1159/000438981
69. Demirkol S, Ozturk C, Balta S, Unlu M, Arslan Z. Is left ventricular diastolic function impaired in patients with ankylosing spondylitis? Int J Rheum Dis. 2015. doi: 10.1111/1756-185X.12778
70. Demirkol S, Ozturk C, Balta S, Unlu M, Arslan Z. What is the actual prevalence and clinical characteristics of mitral valve prolapse? Eur Rev Med Pharmacol Sci. 2015; 19(18): 3330.
71. Balta S, Kucuk U, Demirkol S, Oztur C, Demir M. Waist-Hip Ratio in Patients with Acute Myocardial Infarction. J Clin Diagn Res. 2015; 9(8): OL01. doi: 10.7860/JCDR/2015/8951.6277
72. Demirkol S, Ozturk C, Balta S, Unlu M. Right ventricular function in patients undergoing surgical or transcatheter aortic valve replacement. Eur J Cardiothorac Surg. doi: 10.1093/ejcts/ezv307
73. Celik T, Balta S, Ozturk C, et al. Predictors of No-Reflow Phenomenon in Young Patients With Acute ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention. Angiology. 2015. doi:10.1177/0003319715605977
74. Balta S, Yildirim AO, Demir M, Ozturk C, Aparci M, Celik T. Plasma B-type natriuretic peptide in congenital heart disease. Am J Emerg Med. 2015; 33(11): 1701. doi: 10.1016/j.ajem.2015.07.019
75. Balta S, Uslu AU, Unlu M, Demirkol S, Ozturk C. The relation between neutrophil-lymphocyte ratio and acute kidney injury. Ren Fail. 2015; 37(9): 1527-1528. doi: 10.3109/0886022X.2015.1077311
76. Uslu AU, Aydin B, Inal S, et al. The relationship between red cell distribution width and homozygous M694V mutation in familial Mediterranean fever patients. Ann Saudi Med. 2015; 35(2): 151-156. doi: 10.5144/0256-4947.2015.151
77. Balta S, Demirkol S, Aparci M, Arslan Z, Ozturk C. Red Cell Distribution Width in Myocardial Infarction. Med Princ Pract. 2015; 24(6): 584-585. doi: 10.1159/000437355
78. Balta S, Demırkol S, Unlu M, Ozturk C, Arslan Z, Celık T. Neutrophil-lymphocyte ratio: Can clinicians really trust it as an inflammatory indicator? Cardiol J. 2015; 22(4): 475. doi: 10.5603/CJ.2015.0050
79. Balta S, Demırer Z, Aparci M, Yildirim AO, Ozturk C. The lymphocyte-monocyte ratio in clinical practice. J Clin Pathol. 2015. doi:10.1136/jclinpath-2015-203233
80. Balta S, Aparci M, Ozturk C, Unlu M, Celik T. Carotid intima media thickness can predict coronary artery disease. Int J Cardiol. 2015; 201: 331. doi: 10.1016/j.ijcard.2014.10.100
81. Demirkol S, Ozturk C, Balta S, Unlu M, Arslan Z. Right ventricular diastolic function in patients with community-acquired pneumonia. Am J Emerg Med. 2015 Oct; 33(10): 1521-2. doi: 10.1016/j.ajem.2015.07.022
82. Demirer Z, Uslu AU, Balta S. Letter to the editor: predictive value of the neutrophil-lymphocyte ratio and mean platelet volume in testicular torsion. Korean J Urol. 2015; 56(8): 601-602. doi: 10.4111/kju.2015.56.8.601
83. Ozturk C, Balta S, Ozturk A, Aparci M, Sadir S, Celik T. Inter-Arm Blood Pressure Differences May Be Important for Predicting Mortality. J Clin Hypertens (Greenwich). 2015. doi: 10.1111/jch.12659
84. Kucuk A, Uslu AU, Arslan S, et al. Ischemia-Modified Albumin and Atherosclerosis in Patients With Familial Mediterranean Fever. Angiology. 2015. doi: 10.1177/0003319715595744
85. Iyisoy A, Ozturk C, Tavlasoglu M, et al. Significant left hemothorax after transapical closure of cardiac apex with minithoracotomy and transapical transcatheter prosthetic mitral paravalvular leak closure. Int J Cardiol. 2015; 199: 274-276. doi: 10.1016/j.ijcard.2015.07.030
86. Çakar M, Balta Ş, Şarlak H, et al. Arterial stiffness and endothelial inflammation in prediabetes and newly diagnosed diabetes patients. Arch Endocrinol Metab. 2015; 59(5): 407-413. doi: 10.1590/2359-3997000000061
87. Ozturk C, Demirkol S, Demir M, et al. Mobile mass lesion in the aorta after transcatheter aortic valve implantation:Thrombus or residue calcification. Int J Cardiol. 2015; 198: 45-46. doi: 10.1016/j.ijcard.2015.06.155
88. Ozturk C, Iyisoy A, Celik T, et al. Computed tomography guided percutaneous transapical closure of cardiac apex after prosthetic mitral paravalvular leak closure. Int J Cardiol. 2015; 198: 37-39. doi: 10.1016/j.ijcard.2015.06.121
89. Balta I, Balta S, Karademir I, Demirkol S, Ozturk C, Celik T. Subclinical atherosclerosis in patients with psoriasis. J Saudi Heart Assoc. 2015; 27(3): 222-223. doi: 10.1016/j.jsha.2015.03.006
90. Uslu AU, Inal S, Balta S. Assessment of Platelet-Lymphocyte Ratio Based on EDTA-Dependent Pseudothrombocytopenia. Angiology. 2015. doi: 10.1177/0003319715591331
91. Balta I, Balta S, Karademir I, Demirkol S, Ozturk C, Celik T. Subclinical atherosclerosis in patients with psoriasis. J Saudi Heart Assoc. 2015; 27(3): 222-223. doi: 10.1016/j.jsha.2015.03.006
92. Ünlü M, Balta Ş, Arslan Z, Demirkol S, Öztürk C, Çelik T, Iyisoy A. Ambulatory Blood Pressure Monitoring and Body Mass Index: Good but Not Standardized! Med Princ Pract. 2015; 24(5): 1-3. doi: 10.1159/000431369
93. Balta I, Balta S, Demir M, Ozturk C, Demirkol S. Thrombosis with Behçets disease should be evaluated different conditions. Pan Afr Med J. 2015; 20: 117. doi: 10.11604/pamj.2015.20.117.3571
94. Balta S, Ozturk C. Endocan, Obstructive Sleep Apnea, and Vascular Risk. Angiology. 2015 Jun 15. doi: 10.1177/0003319715591332
95. Balta S, Demirer Z, Aparci M, Demirkol S, Ozturk C. The relation between lymphocyte-monocyte ratio and renal cell carcinoma. Urol Oncol. 2015. doi: 10.1016/j.urolonc.2015.05.004
96. Ozturk C, Balta S, Balta I, Celik T. Neutrophil-Lymphocyte Ratio in Behçet Disease. Angiology. 2015. doi: 10.1177/0003319715586290
97. Bolu A, Balta S. Psychiatric and cardiovascular comorbidities as causes of long-term work disability among individuals with recent-onset rheumatoid arthritis: comments on the article by Kerola et al. Scand J Rheumatol. 2015; 20: 1. doi: 10.3109/03009742.2015.1008039
98. Balta S, Kurtoglu E, Bolu A, Aparci M, Ozturk C. Asymmetric dimethylarginine levels in patients with schizophrenia. Psychiatry Res. 2015; 227(2-3): 369-370. doi: 10.1016/j.psychres.2015.02.018
99. Celik T, Ozturk C, Iyisoy A, et al. Percutaneous mitral annuloplasty in a patient with coronary sinus stenosis and coronary artery compression during procedure; they will not interfere. Int J Cardiol. 2015; 191: 84-86. doi: 10.1016/j.ijcard.2015.04.283
100. Ozturk C, Celik T, Demirkol S, et al. The healing of spontaneous coronary artery dissection with conservative treatment: When to stop. Int J Cardiol. 2015; 189: 249-251. doi: 10.1016/j.ijcard.2015.04.094
101. Balta S, Ozturk C. The Relation between CD40 Ligand and Coronary Artery Disease. Cardiology. 2015; 131(2): 107-108. doi: 10.1159/000381180
102. Balta I, Balta S, Demirkol S, Kucuk U. Thrombotic tendency in patients with Behçets disease. Acta Med Iran. 2015; 53(4): 256.
103. Balta S, Demırkol S, Unlu M, Ozturk C, Arslan Z, Demır M. Electrocardiographic findings in patients with pulmonary embolism. Am J Emerg Med. 2015; 33(6): 838-839. doi: 10.1016/j.ajem.2015.03.004
104. Balta S, Demir M, Demirkol S, Ozturk C, Celik T. Mean platelet volume in patients with varicocele. Andrologia. 2015; 47(4): 365-366. doi: 10.1111/and.12277
105. Ozturk C, Aparci M, Ozturk A, Balta S. High altitude may affect cardiac structure in smoking subjects. Int J Cardiol. 2015; 184: 416. doi: 10.1016/j.ijcard.2015.03.005
106. Bolu A, Balta S, Unlu M, Demirkol S, Ozturk C. The relation between neutrophil-lymphocyte ratio and schizophrenia: commentary on Semiz et al. (2014). Psychiatr Danub. 2015; 27(1): 75-76. Web site. http://www.hdbp.org/psychiatria_danubina/pdf/dnb_vol27_no1/dnb_vol27_no1_75.pdf. Aceessed
107. Sarlak H, Cakar M, Balta S, Demirbas S, Unlu M, Demirkol S. Body mass indexes should be stratified clearly in order to determine increased arterial stiffness in subjects with impaired fasting glucose. J Diabetes Complications. 2015; 29(4): 612. doi: 10.1016/j.jdiacomp.2013.01.005
108. Balta S, Demır M, Demırkol S, Kucuk U, Unlu M, Arslan Z. Anemia and renal dysfunction: Two different conditions but same results in cardiovascular disease. Cardiol J. 2015; 22(1): 121. doi: 10.5603/CJ.2015.0001
109. Kucuk H, Kucuk U, Kolcu Z, Balta S, Demirkol S. Misuse of fentanyl transdermal patch mixed with acute coronary syndrome. Hum Exp Toxicol. 2015. doi: 10.1177/0960327115577516
110. Unlu M, Ozturk C, Demirkol S, et al. Thrombolytic therapy in a patient with inferolateral myocardial infarction after carbon monoxide poisoning. Hum Exp Toxicol. 2015. doi: 10.1177/0960327115577542
111. Ozturk C, Aparci M, Karaduman M, Balta S, Çelik T, İyisoy A. Relationship of Systolic Blood Pressure and Body Mass Index With Left Ventricular Mass and Mass Index in Adolescents. Angiology. 2015. doi: 10.1177/0003319715573102
112. Balta S, Celik T, Mikhailidis DP, et al. The Relation Between Atherosclerosis and the Neutrophil-Lymphocyte Ratio. Clin Appl Thromb Hemost. 2015. doi:
10.1177/1076029615569568
113. Balta S, Mikhailidis DP, Demirkol S, Celik T, Ozturk C, Iyisoy A. Endocan and atherosclerosis. Angiology. 2015; 66(5): 490. doi: 10.1177/0003319715568973
114. Balta S, Aparci M, Demirkol S, Ozturk C, Celik T. Red cell distribution width in primary glomerulonephritides. Ren Fail. 2015; 37(2): 358. doi: 10.3109/0886022X.2014.986622
115. Balta S, Demir M, Demirkol S, Arslan Z, Unlu M, Celik T. Red cell distribution width is related to stroke in patients with heart failure. Clin Appl Thromb Hemost. 2015; 21(2): 190. doi: 10.1177/1076029613509479
116. Balta S, Aparci M, Ozturk C, Demirkol S, Celik T, Iyisoy A. Red cell distribution width in subclinical hypothyroidism. Arq Bras Endocrinol Metabol. 2014; 58(9): 974-975. doi: 10.1590/0004-2730000003452
117. Aparcı M, Öztürk C, Balta Ş, Okutucu S, Işılak Z. Cholesterol; is accused for the atherosclerosis proximal to myocardial bridging? Anadolu Kardiyol Derg. 2014. doi: 10.5152/akd.2014.5803
118. Balta Ş, Çelik T, Aparcı M, Kurtoğlu E, Öztürk C. ADMA is a useful marker, but many confounding factors should be considered! Anatol J Cardiol. 2015. doi: 10.5152/akd.2014.5894
119. Balta S, Ozturk C. The platelet-lymphocyte ratio: A simple, inexpensive and rapid prognostic marker for cardiovascular events. Platelets. 2014: 1-2. doi: 10.3109/09537104.2014.979340
120. Balta I, Balta S, Ozturk C, Demirkol S. Plasma homocysteine level in patients with Behçets disease. Int J Rheum Dis. 2014. doi: 10.1111/1756-185X.12526
121. Balta S, Aparci M, Ozturk C, Demirkol S, Iyisoy A. Red cell distribution width in acute mesenteric ischemia. Perfusion. 2014. doi: 10.1177/0267659114563639
122. Ünlü M, Balta Ş, Arslan Z, Öztürk C, Çelik T, Iyisoy A. The Effect of Metformin on Cardiac Fibrosis via Differentiation of Cardiac Fibroblasts. Cardiology. 2015; 130(1): 52-53. doi: 10.1159/000369127
123. Balta S, Aparci M, Ozturk C, Demir M, Celik T. Neutrophil-Lymphocyte Ratio May Predict the Degree of Coronary Collateral Circulation. Clin Appl Thromb Hemost. 2015; 21(6): 586-587. doi: 10.1177/1076029614564210
124. Demirkol S, Ozturk C, Aparci M, Balta S, Unlu M, Iyisoy A. The effect of age on right ventricular diastolic function parameters. Cardiology. 2015; 130(1): 46. doi: 10.1159/000368748
125. Guler L, Bozkirli F, Bedirli N, et al. Comparison of the Effects of Dexmedetomidine vs. Ketamine in Cardiac Ischemia/Reperfusion Injury in Rats - Preliminary Study. Adv Clin Exp Med. 2014; 23(5): 683-689. Web site. http://www.advances.umed.wroc.pl/pdf/2014/23/5/683.pdf. Accessed
126. Balta S, Aparci M, Ozturk C, Demirkol S, Celik T. Red cell distribution width: a predictor of all-cause mortality in patients with coronary artery disease. Cardiology. 2015; 130(1): 23-24. doi: 10.1159/000368393
127. Arslan Z, Balta S, Demirkol S, et al. Parameters influencing LVEF improvement with intracoronary bone marrow stem cell delivery in acute myocardial infarction. Int J Cardiol. 2014; 177(2): 644-645. doi: 10.1016/j.ijcard.2014.09.179
128. Balta S, Aparci M. The Relation between Renin-Angiotensin-Aldosterone System Blockade and Contrast-Induced Nephropathy: An Unresolved Issue. Cardiology. 2014; 130(1): 1-3. doi: 10.1159/000368300
129. Kucuk U, Isilak Z, Uz O, Balta S. eComment. Doctor Jekyll and Mr Heyde: a vague association between angiodysplasia and aortic stenosis. Interact Cardiovasc Thorac Surg. 2014; 19(6): 932. doi: 10.1093/icvts/ivu401
130. Celık T, Balta S, Karaman M, et al. Endocan, a novel marker of endothelial dysfunction in patients with essential hypertension: Comparative effects of amlodipine and valsartan. Blood Press. 2015; 24(1): 55-60. doi: 10.3109/08037051.2014.972816
131. Aparci M, Ozturk C, Balta S, Okutucu S, Isilak Z. Hypercholesterolemia is Accounted for Atherosclerosis at the Proximal Arterial Segments of Myocardial Bridging: A Pilot Study. Clin Appl Thromb Hemost. 2014. doi: 10.1177/1076029614554995
132. Balta S, Demirkol S, Demir M, Ozturk C, Aparcı M, Celik T. Ankle-brachial index in coronary artery disease. Clinics (Sao Paulo). 2014; 69(9): 653. doi: 10.6061/clinics/2014(09)13
133. Olgun Kucuk H, Kucuk U, Hakan Cansiz K, Balta S, Arslan Z. One biomarker does not fit all. Eur Rev Med Pharmacol Sci. 2014; 18(18): 2594.
134. Balta S, Aparcı M, Ozturk C, Demirkol S, Celik T. Neutrophil-lymphocyte ratio as an useful mortality marker. Am J Emerg Med. 2014; 32(12): 1546-1547. doi: 10.1016/j.ajem.2014.09.040
135. Balta S, Aydogan M, Aparci M, Ozturk C, Demirkol S. Red cell distribution width in patients with sarcoidosis. Clin Respir J. 2014. doi: 10.1111/crj.12182
136. Ozturk C, Balta S, Demirkol S, Unlu M, Celik T, Iyisoy A. The QT measurements after biventricular pacing, is it reliable? J Saudi Heart Assoc. 2014; 26(4): 231-232. doi: 10.1016/j.jsha.2014.02.004
137. Balta I, Balta S, Demirkol S, Ozturk C, Celik T. Neutrophil-to-lymphocyte ratio may predict subclinical atherosclerosis in patients with psoriasis. Echocardiography. 2014; 31(9): 1166-1167. doi: 10.1111/echo.12668
138. Ozturk C, Ozturk A, Cakmak T, Metin S, Balta S, Aparci M, Sen A. Bicuspid aortic valve may affect aortic dimensions in aviators. Aviat Space Environ Med. 2014; 85(8): 867. doi: 10.3357/ASEM.4031.2014
139. Ozturk C, Aparci M, Cakmak T, Metin S, Balta S, Sen A. Atrial fibrillation presented with syncope in a jet pilot during daily briefing on squadron. Aviat Space Environ Med. 2014; 85(9): 965-969. doi: 10.3357/ASEM.3922.2014
140. Kurtoglu E, Balta S, Erdem K, Karakus Y. Asymmetric dimethylarginine and Ramadan fasting. Eur J Clin Nutr. 2014; 68(12): 1368. doi: 10.1038/ejcn.2014.175
141. Balta S, Aparci M, Demir M, Ozturk C, Celik T. Ischemia-modified albumin in patients with seizure. Am J Emerg Med. 2014; 32(10): 1282. doi: 10.1016/j.ajem.2014.06.028
142. Balta S, Demirkol S, Kurtoglu E, Demir M, Kucuk U, Unlu M. Ankle-brachial index in patients with ischaemic stroke. Eur J Neurol. 2014; 21(1): e1. doi: 10.1111/ene.12283
143. Arslan HH, Aparci M, Arslan Z, et al. Increased frequency of mitral valve prolapse in patients with deviated nasal septum. Eur Arch Otorhinolaryngol. 2015; 272(7): 1667-1671. doi: 10.1007/s00405-014-3243-8
144. Kurtoglu E, Balta S, Karakus Y, et al. Ivabradine improves heart rate variability in patients with nonischemic dilated cardiomyopathy. Arq Bras Cardiol. 2014; 103(4): 308-314. doi: 10.5935/abc.20140109
145. Balta S, Demirkol S, Aparcı M, Celik T, Ozturk C. The neutrophil lymphocyte ratio in coronary heart disease. Int J Cardiol. 2014; 176(1): 267. doi: 10.1016/j.ijcard.2014.06.098
146. Balta S, Arslan Z, Kucuk U, Demırkol S, Demır M, Unlu M. Whether taken medication can improve arterial stiffness or not. J Clin Hypertens (Greenwich). 2014; 16(9): 693. doi: 10.1111/jch.12358
147. Balta S, Karademir I, Demirkol S, Ozturk C, Celik T. Red Cell Distribution Width in Patients With Cerebral Venous Sinus Thrombosis. Clin Appl Thromb Hemost. 2014. doi: 10.1177/1076029614543824
148. Aparci M, Okutucu S, Ozturk C, Balta S, Isilak Z. Utility of multi-detector tomography angiography with equivocal exercise stress test in acute coronary syndrome. Emerg Med Australas. 2014; 26(5): 517-518. doi: 10.1111/1742-6723.12269
149. Balta S, Karademir I, Demir M, Ozturk C, Celik T, Demirkol S. Red cell distribution width in pulmonary embolism. Wien Klin Wochenschr. 2014; 126(17-18): 553-554. doi: 10.1007/s00508-014-0572-y
150. Balta S, Aparci M, Ozturk C, Demirkol S, Celik T. Red cell distribution width in organophosphate exposure patients. Am J Emerg Med. 2014; 32(9): 1132. doi: 10.1016/j.ajem.2014.05.032
151. Balta S, Demirkol S, Kucuk U, Celik T, Ozturk C, Iyisoy A. The relationship between neutrophil-lymphocyte ratio and coronary collateral circulation. Perfusion. 2014; 29(4): 367-368. doi: 10.1177/0267659114538483
152. Demirkol S, Balta S, Ozturk C, Celik T, Iyisoy A. Different imaging modalities in quantification of epicardial adipose tissue thickness. J Clin Hypertens (Greenwich). 2014; 16(8): 616. doi: 10.1111/jch.12346
153. Balta I, Balta S, Aparci M, Demirkol S, Ozturk C. Mean platelet volume in patients with systemic lupus erythematosus. Clin Rheumatol. 2014. doi: 10.1007/s10067-014-2705-0
154. Balta S, Demir M, Kucuk U, Demirkol S. Red cell distribution width in patients with coronary artery disease. Intern Med. 2014; 53(11): 1239. doi: 10.2169/internalmedicine.53.1788
155. Olgun Kucuk H, Kucuk U, Cansiz KH, Balta S, Arslan Z. Off-pump coronary artery bypass grafting in patients on chronic hemodialysis. Eur Rev Med Pharmacol Sci. 2014; 18(9): 1434.
156. Dinc M, Cakar M, Balta S, Akhan M, Sarlak H, Demirkol S. The importance of iodine supplementation and smoking for maternal and fetal thyroid health in pregnant women. Eur Thyroid J. 2013; 2(3): 211-22. doi: 10.1159/000351102
157. Oztürk C, Balta S, Metin S, Cakmak T. should obese people be allowed to rise to high altitude? Anadolu Kardiyol Derg. 2014; 14(4): 407-408. doi: 10.5152/akd.2014.5404
158. Iyisoy A, Demirkol S, Celik T, Balta S. Case images: Percutaneous transcatheter closure of atrial and ventricular septal defect in the same session. Turk Kardiyol Dern Ars. 2014; 42(3): 314. doi: 10.5543/tkda.2014.01346
159. Olgun Kucuk H, Kucuk U, Asker M, Balta S. Three dimensional insight to Austin Flint murmur. Int J Cardiol. 2014; 174(2): e24-e25. doi: 10.1016/j.ijcard.2014.03.073
160. Ozturk C, Balta S, Demirkol S, Celik T, Iyisoy A. Epicardial adipose tissue thickness may be related diastolic dysfunction in obese adolescents. Eur Rev Med Pharmacol Sci. 2014; 18(7): 1109.
161. Cakmak T, Metin S, Ozturk C, Balta S. Managing acute coronary syndrome during medical air evacuation from a remote location at sea. Aviat Space Environ Med. 2014; 85(4): 480. doi: 10.3357/ASEM.3947.2014
162. Demirkol S, Balta S, Arslan Z, Kucuk U, Unlu M. The association between vitamin D level and extent of coronary stenotic lesions. Cardiol J. 2014; 21(2): 206-207. doi: 10.5603/CJ.2014.0030
163. Balta I, Balta S, Ozturk C, Kurtoglu E. Increased arterial stiffness is independently associated with metabolic syndrome and damage index in systemic lupus erythematosus patients: comment on the article by Valero-Gonzalez et al. Scand J Rheumatol. 2014; 43(5): 432. doi: 10.3109/03009742.2014.893014
164. Balta S, Kurtoglu E, Kucuk U, Demirkol S, Ozturk C. Neutrophil-lymphocyte ratio as an important assessment tool. Expert Rev Cardiovasc Ther. 2014; 12(5): 537-538. doi: 10.1586/14779072.2014.902309
165. Balta S. Comment on: renal impairment and coronary collaterals in patients with acute coronary syndrome. Herz. 2014; 39(4): 481-482. doi: 10.1007/s00059-013-3948-2
166. Balta S, Demir M, Ozturk C, Celik T. Arterial stiffness in patients with bronchial asthma. Respir Med. 2014; 108(6): 940. doi: 10.1016/j.rmed.2013.12.017
167. Balta I, Balta S, Demir M, Ozturk C, Demirkol S. P-wave duration dispersion in patients with lichen planus. Clinics (Sao Paulo). 2014; 69(4): 304. doi:
10.6061/clinics/2014(04)12
168. Ozturk C, Demirkol S, Balta S, Bozlar U, Unlu M. Multiple pseudoaneurysms of aortic arch in a patient with Behcets disease. Eur Heart J Cardiovasc Imaging. 2014; 15(9): 1028. doi: 10.1093/ehjci/jeu047
169. Balta S, Demırkol S, Kurt O, Unlu M, Iyısoy A, Sarlak H. Inflammatory status in patients with coronary artery disease. Eur Rev Med Pharmacol Sci. 2014; 18(6): 939-940.
170. Ozturk C, Balta S, Demirkol S, Ozturk A, Celik T, Iyisoy A. High BNP levels in rheumatoid arthritis may be related with right ventricular functions. Int J Cardiol. 2014; 174(1): 149-150. doi: 10.1016/j.ijcard.2014.03.157
171. Balta S, Balta I, Mikhailidis DP, et al. Bilirubin levels and their association with carotid intima media thickness and high-sensitivity C-reactive protein in patients with psoriasis vulgaris. Am J Clin Dermatol. 2014; 15(2): 137-142. doi: 10.1007/s40257-014-0069-5
172. Ozturk C, Balta S, Demirkol S, et al. Increased platelet indices in acute stent thrombosis. Angiology. 2014; 65(8): 744. doi: 10.1177/0003319714529181
173. Ozturk C, Balta S, Balta I, et al. Neutrophil-Lymphocyte Ratio and Carotid-Intima Media Thickness in Patients With Behcet Disease Without Cardiovascular Involvement. Angiology. 2014. 2015; 66(3): 291-296. doi: 10.1177/0003319714527638
174. Balta I, Balta S, Ozturk C. Thrombotic therapy in patients with Behçets disease. Expert Rev Cardiovasc Ther. 2014; 12(4): 413-414. doi: 10.1586/14779072.2014.896197
175. Balta I, Balta S, Demirkol S, Demir M, Ozturk C. Assessment of arterial stiffness in patients with inactive and active Behçets disease: comments on the article by Yilmaz et al. Scand J Rheumatol. 2014; 43(4): 347-348. doi: 10.3109/03009742.2013.875585
176. Kucuk U, Kucuk HO, Cansiz KH, Balta S. eComment. Thrombus strikes back: promising role of thromboelastography for thromboembolic risk prediction in HeartMate II recipients. Interact Cardiovasc Thorac Surg. 2014; 18(4): 465. doi: 10.1093/icvts/ivu047
177. Ozturk C, Balta S, Ozturk A. Inter-arm blood pressure differences in aviators: is it important? J Clin Hypertens (Greenwich). 2014; 16(5): 387. doi: 10.1111/jch.12280
178. Balta I, Balta S, Demırkol S, Demır M, Celık T. Vitamin D levels in patients with Behçets disease. Int J Rheum Dis. 2014; 17(4): 479-480. doi: 10.1111/1756-185X.12236
179. Balta S, Kurtoglu E, Ozturk C, Demırkol S, Demır M. Arterial stiffness and pentraxin 3 levels in obese patients. Am J Hypertens. 2014; 27(6): 881. doi: 10.1093/ajh/hpu018
180. Balta S, Kucuk U, Demirkol S, Demir M, Ozturk C. Arterial stiffness parameters in patients with chronic kidney disease. J Clin Hypertens (Greenwich). 2014; 16(2): 157. doi: 10.1111/jch.12254
181. Demirkol S, Balta S, Kucuk U, Kucuk HO. The neutrophil lymphocyte ratio may be useful inflammatory indicator before applying other expensive and invasive procedures. Indian J Nephrol. 2014; 24(1): 65-66. doi: 10.4103/0971-4065.125135
182. Balta S, Ozturk C, Demirkol S, Demir M. Adiponectin levels in hemodialysis patients. Ther Apher Dial. 2014; 18(2): 214-215. doi: 10.1111/1744-9987.12181
183. Demirkol S, Balta S, Bozlar U. Diffuse mural thrombus in a patient with thoracic aortic aneurysm. Asian Cardiovasc Thorac Ann. 2013; 21(4): 490. doi: 10.1177/0218492312457925
184. Balta S, Aydogan M, Demirkol S, Cakar M, Akgul EO, Sarlak H. Red cell distribution width: a novel and simple predictor of mortality in chronic obstructive pulmonary disease. COPD. 2014; 11(4): 475-476. doi: 10.3109/15412555.2013.813449
185. Oztürk C, Balta S. Does bilirubin level have an effect on cardiac parameters? Anadolu Kardiyol Derg. 2014; 14(2): 213. doi: 10.5152/akd.2014.5361
186. Kurtoglu E, Balta S. Other factors may effect the relationship between heart rate variability indices and coronary atherosclerosis. Clin Auton Res. 2014; 24(2): 89. doi: 10.1007/s10286-014-0230-5
187. Balta S, Demirkol S, Arslan Z. Quadricuspid aortic valve without severe regurgitation in pectus excavatum. Asian Cardiovasc Thorac Ann. 2013; 21(2): 240. doi: 10.1177/0218492312449826
188. Balta S, Demir M, Kurtoglu E, Demirkol S. Mean platelet volume in patients with sensorineural hearing loss. J Laryngol Otol. 2014; 128(2): 217-218. doi: 10.1017/S0022215114000164
189. Balta Ş, Balta İ, Demirkol S, Yeşil FG. Hypoplastic aorta in a patient with familial hypercholesterolemia. Anadolu Kardiyol Derg. 2013; 13(8): E46. doi: 10.5152/akd.2013.4891
190. Balta I, Balta S, Ozturk C, Demirkol S, Demir M. Epicardial fat thickness in psoriasis patients. Dermatology. 2014; 228(2): 132-133. doi: 10.1159/000357403
191. Kucuk U, Olgun Kucuk H, Balta S, Arslan Z. Tiny magnetomers and future of magnetocardiography. Int J Cardiol. 2014; 172(2): e268. doi: 10.1016/j.ijcard.2013.12.102
192. Kurtoglu E, Balta S, Karakus Y, Yasar E, Gozubuyuk G. The unnormalized spectral indices of heart rate variability should be presented in conjunction with normalized versions of the same variables. Sleep Med. 2014; 15(7): 843. doi: 10.1016/j.sleep.2013.12.006
193. Kurtoglu E, Balta S, Karakus Y, Yasar E. Other factors ought to be kept in mind when analyzing plasma asymmetric dimethylarginine levels. Am J Hypertens. 2014; 27(3): 500. doi: 10.1093/ajh/hpt275
194. Balta S, Kurtoglu E, Unlu M, Demirkol S, Arslan Z. Red cell distribution width in renal transplant patients. Int Urol Nephrol. 2014; 46(7): 1465-1466. doi: 10.1007/s11255-014-0649-6
195. Cakar M, Balta S, Sarlak H, Demirkol S. The nutritional status of the patients with renal failure should be assessed carefully. Hippokratia. 2013; 17(3): 285.
196. Balta S, Demir M, Kurtoglu E, Demirkol S. Red cell distribution width in patients with nonalcoholic fatty liver disease. Eur J Gastroenterol Hepatol. 2014; 26(3): 361. doi: 10.1097/MEG.0000000000000017
197. Balta I, Balta S, Demirkol S, Unlu M, Demir M. Lipid levels in patients with Behcets disease. Eur Rev Med Pharmacol Sci. 2014; 18(1): 142.
198. Balta S, Demırkol S, Arslan Z, Demır M, Ozturk C. The neutrophil lymphocyte ratio in patients with ST segment elevation myocardial infarction. Eur Rev Med Pharmacol Sci. 2014; 18(1): 141.
199. Balta S, Demırkol S, Celık T, Demır M, Unlu M. Arterial stiffness in patients with ischemic attack. Int J Stroke. 2014; 9(2): E5. doi: 10.1111/ijs.12238
200. Balta S, Demirkol S, Ozturk C, Demir M, Iyisoy A. Heart rate variability in patients with chest pain at the ED. Am J Emerg Med. 2014; 32(3): 284-285. doi: 10.1016/j.ajem.2013.11.050
201. Balta S, Demirkol S, Demir M, Ozturk C, Celik T. Ankle brachial index in hemodialysis patients. Ther Apher Dial. 2014; 18(1): 113-114. doi: 10.1111/1744-9987.12156
202. Kurtoglu E, Balta S, Karakus Y, Yasar E. Frequency domain parameters of heart rate variability should also be quoted in normalised units. Acta Anaesthesiol Scand. 2014; 58(3): 370-371. doi: 10.1111/aas.12261
203. Balta S, Demirkol S, Ozturk C. The neutrophil lymphocyte ratio in patients with glioblastoma multiforme. J Neurooncol. 2014; 117(1): 195-196. doi: 10.1007/s11060-013-1355-4
204. Kurtoglu E, Balta S, Karakus Y, Yasar E. Pediatric guillain-barré syndrome and autonomic dysfunction. J Cardiovasc Thorac Res. 2013; 5(4): 179. doi: 10.5681/jcvtr.2013.039
205. Balta S, Mikhailidis DP, Demirkol S, et al. Endocan--a novel inflammatory indicator in newly diagnosed patients with hypertension: a pilot study. Angiology. 2014; 65(9): 773-777. doi: 10.1177/0003319713513492
206. Demirkol S, Balta S, Dinc M, Ay SA, Kucuk U, Unlu M. Arterial stiffness should be evaluated with other inflammatory markers in patients with subclinical hypothyroidism. Arq Bras Endocrinol Metabol. 2013; 57(9): 754-755. doi: 10.1590/S0004-27302013000900015
207. Balta S, Demirkol S, Kucuk U, Unlu M, Arslan Z, Demir M. The effect of different circadian blood pressure rhythms on left ventricular systolic dyssynchrony in patients with newly diagnosed essential hypertension. Echocardiography. 2014; 31(1): 120-121. doi: 10.1111/echo.12415
208. Demirkol S, Samedli S, Balta Ş, Bozlar U. A mass compressing the left atrium. Bronchogenic cyst. Anadolu Kardiyol Derg. 2014; 14(1): 95-104. doi: 10.5152/akd.2013.4792
209. Balta Ş, Demirkol S, Küçük U, Demir M, Arslan Z, Ünlü M. YKL-40 levels in patients with coronary artery ectasia. Anadolu Kardiyol Derg. 2014; 14(1): 97-98. doi: 10.5152/akd.2013.5177
210. Dinc M, Aydin E, Balta S, Demirkol S, Karaman M. Subclinical inflammation and cardiovascular risk in psoriasis. J Intern Med. 2014; 276(2): 195. doi: 10.1111/joim.12185
211. Demirkol S, Balta S. Authors reply. Turk Kardiyol Dern Ars. 2013; 41(6): 577-578.
212. Demirkol S, Balta Ş, Arslan Z, Küçük U, Ünlü M. Klinik pratiğimizin kolay, ucuz ve invaziv olmayanenflamasyon belirteci olarak ortalama trombosit hacmi. Turk Kardiyol Dern Ars. 2013; 41(6): 575.
a. Balta S, Kurtoglu E, Demir M, Demirkol S, Arslan Z, Unlu M. Risk factors for new-onset atrial fibrillation. Int J Cardiol. 2014; 171(2): e46. doi: 10.1016/j.ijcard.2013.11.115
213. Demirkol S, Balta S, Kucuk U, et al. Association between microvascular angina and erectile dsyfunction. Int J Impot Res. 2014; 26(4): 124-127. doi: 10.1038/ijir.2013.49
214. Balta S, Demirkol S, Kucuk U, Arslan Z, Unlu M, Veliyev V. Carotid intima-media thickness is a relatively inexpensive and favorable prognostic marker in patients with spondyloarthritis. Sao Paulo Med J. 2013; 131(6): 436-438. doi: 10.1590/1516-3180.2013.1316728
215. Balta S, Demir M, Kucuk U, Arslan Z, Demirkol S. Red cell distribution width in patients with atrial fibrillation. J Intern Med. 2014; 275(5): 545. doi: 10.1111/joim.12182
216. Dinc M, Balta S, Cakar M, Akhan M, Sarlak H, Unlu M. What is the contribution of physical activity on outcome in patients with type 2 diabetes mellitus? Arq Bras Endocrinol Metabol. 2013; 57(8): 663-664. doi: 10.1590/S0004-27302013000800014
217. Demirkol S, Balta S, Kucuk U, Kucuk HO, Kurt O, Sarlak H. The neutrophil lymphocyte ratio may be useful inflammatory indicator before applying other expensive and invasive procedures. Indian J Ophthalmol. 2013; 61(11): 685. doi: 10.4103/0301-4738.123150
218. Balta S, Demirkol S, Unlu M, Kucuk U, Arslan Z, Demir M. Higher mean platelet volume level in patients with pulmonary embolism. Clin Respir J. 2014; 8(2): 251-252. doi: 10.1111/crj.12067
219. Balta S, Kucuk U, Arslan Z, Unlu M, Demirkol S. Mean platelet volume may be confused in many conditions. Wien Klin Wochenschr. 2014; 126(7-8): 248-249. doi: 10.1007/s00508-013-0490-4
220. Balta S, Demirkol S, Arslan Z, Unlu M, Yesil FG, Celik T. Red cell distribution width may be related to the degree of coronary collateral circulation. Clin Appl Thromb Hemost. 2014; 20(1): 107. doi: 10.1177/1076029613481104
221. Balta I, Balta S, Aydin E, Demirkol S, Unlu M, Arslan Z. Heart rate recovery index in patients with psoriasis. Med Princ Pract. 2014; 23(2): 192. doi: 10.1159/000357298
222. Balta I, Balta S, Demir M, Ozturk C, Demirkol S. Thrombotic events in Behçets disease. Am J Emerg Med. 2014; 32(2): 184-185. doi: 10.1016/j.ajem.2013.10.053
223. Balta S, Demırkol S, Kucuk U, Cakar M, Unlu M. Neutrophil-to-lymphocyte ratio as a novel independent prognostic factor in urothelial carcinoma. Clin Genitourin Cancer. 2014; 12(2): e69-e70. doi: 10.1016/j.clgc.2013.07.014
224. Balta S, Demir M, Kucuk U, Arslan Z, Demirkol S, Unlu M. Masked hypertension as an unrecognized destructive condition. J Clin Hypertens (Greenwich). 2014; 16(2): 155. doi: 10.1111/jch.12240
225. Ekiz O, Balta I, Sen BB, Rifaioglu EN, Balta S, Demirkol S. The etiology of Behçet disease: is it really inflammation or not! Angiology. 2014; 65(4): 327. doi: 10.1177/0003319713515298
226. Balta S, Ozturk C, Kurtoglu E. The neutrophil-lymphocyte ratio is not enough to describe inflammatory condition. Eur Arch Otorhinolaryngol. 2014; 271(6): 1839-1840. doi: 10.1007/s00405-013-2847-8
227. Ozturk C, Cakmak T, Metin S, Balta S, Aparci M. Acceleration forces can effect cardiovascular structure. J Physiol Sci. 2014; 64(2): 157-158. doi: 10.1007/s12576-013-0299-y
228. Balta S, Demirkol S, Unlu M, Kucuk U, Arslan Z. Mean platelet volume in patients with ischemic stroke. Eur Rev Med Pharmacol Sci. 2013; 17(22): 3121-3122.
229. Balta S, Balta I, Demirkol S, Ozturk C, Demir M. Endothelial function and Behçet disease. Angiology. 2014; 65(8): 657-659. doi: 10.1177/0003319713513146
230. Celik T, Kaya MG, Akpek M, et al. Predictive Value of Admission Platelet Volume Indices for In-hospital Major Adverse Cardiovascular Events in Acute ST-Segment Elevation Myocardial Infarction. Angiology. 2015; 66(2): 155-162. doi: 10.1177/0003319713513493
231. Cakar M, Bulucu F, Karaman M, et al. Asymmetric dimethylarginine and augmentation index in newly diagnosed patients with hypertension. Angiology. 2015; 66(1): 43-48. doi: 10.1177/0003319713513145
232. Balta S, Demir M, Demirkol S, Unlu M, Kucuk U, Arslan Z. Arterial stiffness in patients with peripheral arterial disease. J Clin Hypertens (Greenwich). 2013; 15(12): 938. doi: 10.1111/jch.12195
233. Unlu M, Demirkol S, Balta S, Bozlar U, Kucuk U. Pulmonary artery aneurysm mimicking pulmonary artery dissection detected by multimodality imaging. Kardiol Pol. 2013; 71(11): 1180-1182. doi: 10.5603/KP.2013.0300
234. Balta S, Canpolat U. Association of epicardial fat thickness with TIMI risk score. Herz. 2014; 39(6): 718. doi: 10.1007/s00059-013-4001-1
235. Kucuk U, Kucuk HO, Balta S, Arslan Z. eComment. Three-dimensional printers remodelling cardiac interventions. Interact Cardiovasc Thorac Surg. 2013; 17(6): 1050. doi: 10.1093/icvts/ivt459
236. Demirkol S, Cakar M, Balta S, Unlu M. Are leptin levels a cause or an indicator of cardiovascular risk? Rev Port Cardiol. 2013; 32(11): 953. doi: 10.1016/j.repc.2013.01.011
237. Balta S, Demirkol S, Unlu M, Celik T. Red cell distribution width is a predictor of mortality in patients with major bleeding. Rev Port Cardiol. 2013; 32(10): 843-844. doi: 10.1016/j.repc.2013.02.015
238. Balta S, Demirkol S, Arslan Z, Demir M, Unlu M, Kucuk U. Non-alcoholic fatty liver disease may be associated with endothelial dysfunction. Ups J Med Sci. 2014; 119(1): 57. doi: 10.3109/03009734.2013.851749
239. Balta S, Demir M, Demirkol S, Kucuk U, Unlu M, Arslan Z. Uric acid level in patients with kidney disease. Cardiology. 2014; 127(1): 25. doi: 10.1159/000355002
240. Sarlak H, Demirkol S, Balta S, Cakar M, Kurt O, Akhan M. Quality of life scores should be compared before and after patients have undergone dialysis. Ann Saudi Med. 2013; 33(5): 510. doi: 10.5144/0256.4947.2013.510a
241. Kurtoğlu E, Balta S, Sincer I, Yilmaz M. Different types of statins might act differently in reducing plasma asymmetric dimethylarginine levels. Pol Arch Med Wewn. 2013; 123(10): 562-563.
242. Balta S, Demir M, Demirkol S, Unlu M. Plasma B-type natriuretic peptide level in patients with coronary artery bypass surgery. Kaohsiung J Med Sci. 2013; 29(11): 648-649. doi: 10.1016/j.kjms.2013.09.006
243. Balta S, Demirkol S, Cakar M, Kurt O, Unlu M, Kucuk U. Mean platelet volume and mitral annular calcification. Blood Coagul Fibrinolysis. 2013; 24(8): 899. doi: 10.1097/MBC.0b013e328362df02
244. Balta I, Balta S, Koryurek OM, et al. Serum endocan levels as a marker of disease activity in patients with Behçet disease. J Am Acad Dermatol. 2014; 70(2): 291-296. doi: 10.1016/j.jaad.2013.09.013
245. Balta S, Demirkol S, Cakar M, Celik T. Mean platelet volume as a surrogate marker of low-grade inflammation in osteoarthritis. Platelets. 2014; 25(8): 643-644. doi: 10.3109/09537104.2013.786824
246. Balta S, Mikhailidis DP, Kurtoglu E, Demirkol S. Mean platelet volume in patients undergoing percutaneous coronary intervention. Platelets. 2013. doi: 10.3109/09537104.2013.842207
247. Demirkol S, Bozlar U, Balta S, Yokuşoğlu M. Multimodality imaging of type 4 persistent truncus arteriosus in an adult patient. Anadolu Kardiyol Derg. 2013; 13(7): E40-E41. doi: 10.5152/akd.2013.256
248. Kurt O, Arslan E, Balta S, Cakar M, Güler K, Demirkol S. [Surgical treatment of hypertension]. Anadolu Kardiyol Derg. 2013; 13(7): 725-726. doi: 10.5152/akd.2013.246
249. Karaman M, Cakar M, Balta S, Ay SA, Dinç M, Demirkol S. The protection of therapeutic lifestyle change in individuals with prehypertension; a valuable study. Anadolu Kardiyol Derg. 2013; 13(7): 723. doi: 10.5152/akd.2013.244
250. Balta I, Balta S, Demirkol S, Küçük U, Aydın E. Flow-mediated dilatation measurement as a simple practical method in Behçets diseases without cardiovascular involvement. Anadolu Kardiyol Derg. 2013; 13(7): 720-721. doi: 10.5152/akd.2013.242
251. Balta S, Demirkol S, Kucuk U, Unlu M, Arslan Z, Celik T. Mean platelet volume as a mirror of all inflammatory conditions. Eur J Ophthalmol. 2014; 24(3): 454-455. doi: 10.5301/ejo.5000380
252. Balta I, Balta S, Koryurek OM, et al. Mean platelet volume is associated with aortic arterial stiffness in patients with Behçets disease without significant cardiovascular involvement. J Eur Acad Dermatol Venereol. 2014; 28(10): 1388-1393. doi: 10.1111/jdv.12297
253. Kurtoglu E, Balta S, Sincer I, et al. Comparision of effects of rosuvastatin versus atorvastatin treatment on plasma levels of asymmetric dimethylarginine in patients with hyperlipidemia having coronary artery disease. Angiology. 2014; 65(9): 788-793. doi: 10.1177/0003319713507333
254. Balta S, Unlu M, Arslan Z, Demırkol S. Neutrophil-to-Lymphocyte Ratio in Prognosis of Gastric Cancer. J Gastric Cancer. 2013; 13(3): 196-197. doi: 10.5230/jgc.2013.13.3.196
255. Balta S, Demirkol S, Kucuk U, Sarlak H, Kurt O, Arslan Z. Neutrophil to lymphocyte ratio may predict mortality in breast cancer patients. J Breast Cancer. 2013; 16(3): 354-355. doi: 10.4048/jbc.2013.16.3.354
256. Balta I, Balta S, Demirkol S, Unlu M, Arslan Z. Carotid intima-media thickness as a novel inflammatory marker in psoriasis: comment on the article by Lin et al. Arthritis Care Res (Hoboken). 2014; 66(5): 793. doi: 10.1002/acr.22210
257. Balta S, Kucuk U, Arslan Z, Unlu M, Demirkol S, Celik T. Increased red cell distribution width in patients with slow coronary flow. Clinics (Sao Paulo). 2013; 68(9): 1288. doi: 10.6061/clinics/2013(09)16
258. Kurtoglu E, Balta S, Sincer I, Korkmaz H. Letter by Kurtoglu et al regarding article, "Asymmetric dimethylarginine in response to recombinant tissue-type plasminogen activator and erythropoietin in acute stroke". Stroke. 2013; 44(12): e229. doi: 10.1161/STROKEAHA.113.003236
259. Kurt Ö, Cakar M, Balta S, Sarlak H, Akhan M, Arslan E. Smoking and the renal functional status of patients should be defined clearly in order to assess atherosclerosis and metabolic syndrome. Intern Med. 2013; 52(20): 2389. doi: 10.2169/internalmedicine.52.0568
260. Sarlak H, Akhan M, Cakar M, Kurt O, Arslan E, Balta S. N-terminal pro-B-type natriuretic peptide should be used in all dyspneic patients in the ED. Am J Emerg Med. 2013; 31(12): 1711. doi: 10.1016/j.ajem.2013.08.039
261. Karaman M, Balta S, Cakar M, Ay SA, Dinc M. Lifestyle change important for patients with hypertension and cardiovascular diseases. J Clin Hypertens (Greenwich). 2013; 15(11): 858. doi: 10.1111/jch.12207
262. Balta S, Demir M, Demirkol S, Kucuk U, Unlu M, Arslan Z. Arterial stiffness in patients with lower urinary tract symptoms. Scand J Urol. 2014; 48(2): 225-256. doi:
10.3109/21681805.2013.846937
263. Balta S, Demirkol S, Cakar M, Aydogan M, Akhan M. The red cell distribution width may be affected by many factors in the clinical practice. J Clin Diagn Res. 2013; 7(8): 1830. doi: 10.7860/JCDR/2013/6007.3294
264. Balta S, Demirkol S, Unlu M, Arslan Z, Celik T. Neutrophil to lymphocyte ratio may be predict of mortality in all conditions. Br J Cancer. 2013; 109(12): 3125-3126. doi: 10.1038/bjc.2013.598
265. Demirkol S, Balta S, Kucuk U, Celik T, Unlu M. Current opinions about coronary artery ectasia. Angiology. 2013; 64(8): 634-635. doi: 10.1177/0003319713491625
266. Balta S, Kucuk U, Cakar M, Demirkol S, Unlu M, Arslan Z. Re: correlation between ankle-brachial index and microalbuminuria in type 2 diabetes mellitus. Iran J Kidney Dis. 2013; 7(5): 415-416. Web site. http://europepmc.org/abstract/med/24072158. Accessed
267. Balta S, Demir M, Demirkol S, Arslan Z. eComment. Atrial fibrillation in patients undergoing thoracic surgery. Interact Cardiovasc Thorac Surg. 2013; 17(4): 686-687. doi: 10.1093/icvts/ivt369
268. Balta S, Demirkol S, Unlu M, Arslan Z. eComment. Renal dysfunction may predict early and late cardiovascular events. Interact Cardiovasc Thorac Surg. 2013; 17(4): 643. doi: 10.1093/icvts/ivt344
269. Demirkol S, Balta S, Sarı S, Bozlar U. Multimodality imaging of persistent left superior vena cava and an absent right superior vena cava in a patient with dextrocardia. Anadolu Kardiyol Derg. 2013; 13(6): E31.
270. Demirkol S, Balta S, Cakar M, Küçük U. Does left ventricular function deteriorate in patients with nasal polyposis? Anadolu Kardiyol Derg. 2013; 13(6): 613. doi: 10.5152/akd.2013.209
271. Balta S, Demirkol S, Kurt Ö, Sarlak H, Akhan M. Epicardial adipose tissue measurement: inexpensive, easy accessible and rapid practical method. Anadolu Kardiyol Derg. 2013; 13(6): 611. doi: 10.5152/akd.2013.207
272. Demirkol S, Balta S, Kucuk U, Kucuk HO. Mean platelet volume may be associated with extent of coronary artery disease. Arq Bras Cardiol. 2013; 101(3): 284-285. doi: 10.5935/abc.20130176
273. Demirkol S, Arslan Z, Balta S, Kucuk U. Authors reply. Turk Kardiyol Dern Ars. 2013; 41(5): 465-466.
274. Balta S, Demirkol S, Cakar M, Kurt O, Unlu M, Kucuk U. Serum visfatin levels should be evaluated with further markers of endolthelial inflamation. Arch Iran Med. 2013; 16(8): 496. Web site. http://europepmc.org/abstract/med/24059006. Accessed
275. Yalcin M, Aparci M, Uz O, et al. Neutrophil-Lymphocyte Ratio May Predict Left Atrial Thrombus in Patients With Nonvalvular Atrial Fibrillation. Clin Appl Thromb Hemost. 2015; 21(2): 166-171. doi: 10.1177/1076029613503398
276. Demirkol S, Balta S, Cakar M, Kucuk U, Kurt O, Dinc M. Incremental value of real time 3D transesophageal echocardiography to detect coronary ostium in patients undergoing transapical aortic valve implantation. J Cardiothorac Vasc Anesth. 2013; 27(5): e53-e54. doi: 10.1053/j.jvca.2013.04.012
277. Ekiz O, Balta I, Sen BB, Rifaioglu EN, Balta S, Demirkol S. Mean platelet volume as an inflammatory indicator in behcet disease. Angiology. 2014; 65(2): 167. doi: 10.1177/0003319713503033
278. Balta S, Demirkol S, Unlu M, Arslan Z, Demir M, Kucuk U. Coronary artery ectasia as a histopathological pattern of atherosclerosis. Angiology. 2014; 65(1): 86. doi: 10.1177/0003319713503396
279. Demirkol S, Balta S, Bozlar U, Samedli S, Cakar M, Sari S. Multimodality imaging of a hiatal hernia compressing the left atrium. Kardiol Pol. 2013; 71(8): 883. doi: 10.5603/KP.2013.0210
280. Demirkol S, Balta S, Kucuk U, Unlu M, Cakar M, Dinc M. Response to Improvement of arterial stiffness in the transition from acute decompensated heart failure to chronic compensated heart failure. Clin Cardiol. 2013; 36(12): E49. doi: 10.1002/clc.22211
281. Hatipoglu M, Balta S, Cakar M, Demirkol S, Kurt O, Dinc M. Modified Hodge test as screening test for spreading carbapenemase resistance has become more important. Clinics (Sao Paulo). 2013; 68(8): 1175. doi: 10.6061/clinics/2013(08)18
282. Kurt Ö, Balta S, Cakar M, Demirkol S, Akhan M, Arslan E. Is there a higher cardiovascular disease risk in Japanese-Brazilians? Arq Bras Endocrinol Metabol. 2013; 57(6): 494-495. doi: 10.1590/S0004-27302013000600015
283. Balta S, Demırkol S, Karaman M. Renal dysfunction may predict new onset heart failure. Am Heart J. 2013; 166(3): e5. doi: 10.1016/j.ahj.2013.06.005
284. Balta I, Balta S, Demir M, Demirkol S, Ekiz O, Unlu M. Arterial stiffness parameters should be evaluated with different types of psoriasis. Angiology. 2014; 65(1): 83. doi: 10.1177/0003319713501854
285. Balta S, Demirkol S, Kucuk U, Arslan Z, Unlu M, Demir M. Fragmented QRS in patients with acute myocardial infarction. Heart Lung. 2013; 42(6): 448. doi: 10.1016/j.hrtlng.2013.08.002
286. Demirkol S, Kurt O, Balta S, Cakar M. Prevalence of hypertension in Portuguese adolescents. Rev Port Cardiol. 2013; 32(9): 741. doi: 10.1016/j.repc.2012.12.021
287. Balta S, Demirkol S, Kucuk U, Unlu M, Arslan Z, Celik T. The relation between N-terminal pro-B-type natriuretic peptide and heart failure. Am J Emerg Med. 2013; 31(10): 1533. doi: 10.1016/j.ajem.2013.07.022
288. Balta S, Demirkol S, Unlu M, Arslan Z. Mean platelet volume and glomerular filtration rate: Two important risk determinants in coronary artery disease. Platelets. 2015; 26(1): 97-98. doi: 10.3109/09537104.2013.825711
289. Cakar M, Demirbas S, Yildizoglu U, et al. First report of endocarditis by Alloiococcus otitidis spp. in a patient with a history of chronic otitis. J Infect Public Health. 2013; 6(6): 494-495. doi: 10.1016/j.jiph.2013.07.002
290. Balta S, Demirkol S, Kucuk U, Arslan Z, Unlu M. Renal failure in patients with acute heart failure. Int J Cardiol. 2013; 168(5): e131. doi: 10.1016/j.ijcard.2013.08.034
291. Balta S, Demirkol S, Unlu M, Kucuk U, Arslan Z. Current opinion: mean platelet volume is one of the most important parameters at the first glance. Med Princ Pract. 2014; 23(2): 189. doi: 10.1159/000354738
292. Balta S, Cakar M, Demırkol S, Kucuk U, Ay SA, Unlu M. May chest pain describe coronary heart disease? Croat Med J. 2013; 54(4): 411. doi: 10.3325/cmj.2013.54.411
293. Balta S, Demirkol S, Mustafa C, Dinc M, Kurt O, Sarlak H. Red cell distribution width itself without other inflammatory markers may not accurately provide information about severity of coronary artery disease. Chin Med J (Engl). 2013; 126(16): 3190. Web site. http://s3.amazonaws.com/academia.edu.documents/45146844/Red_cell_distribution_width_itself_witho20160427-22192-1tlzyow.pdf?AWSAccessKeyId=AKIAJ56TQJRTWSMTNPEA&Expires=1467271327&Signature=n9nPkPBj0%2B3g2ovQridnUj9ScqU%3D&response-content-disposition=inline%3B%20filename%3DRed_cell_distribution_width_itself_witho.pdf Accessed
294. Balta S, Demırkol S, Kucuk U. The neutrophil lymphocyte ratio level in patients with end-stage renal disease. Hemodial Int. 2014; 18(1): 216-217. doi: 10.1111/hdi.12079
295. Balta S, Demirkol S, Cakar M, Karaman M, Ay SA, Arslan Z. Cell-free circulating DNA as a novel biomarker in patients with the acute coronary syndrome. Cardiology. 2013; 126(2): 122-123. doi: 10.1159/000353266
296. Sarlak H, Akhan M, Cakar M, Kurt O, Arslan E, Balta S. A larger weight reduction is necessary to elicit an increase in adiponectin and a decrease in leptin levels. J Intern Med. 2013; 274(6): 614. doi: 10.1111/joim.12122
297. Balta S, Demirkol S, Kucuk U, Arslan Z, Unlu M, Celik T. Atrial fibrillation in patients with acute coronary syndromes. Int J Cardiol. 2013; 168(5): 5049. doi: 10.1016/j.ijcard.2013.07.214
298. Olgun Kucuk H, Kucuk U, Balta S, Demirkol S. A therapeutic dilemma: quality versus quantity. Cardiology. 2013; 126(2): 96. doi: 10.1159/000351093
299. Sarlak H, Akhan M, Cakar M, Kurt O, Arslan E, Balta S. Admission hyperglycemia may be the result of counterregulatory hormones during acute coronary syndrome events. Angiology. 2014; 65(2): 160. doi: 10.1177/0003319713498150
300. Fici F, Celik T, Balta S, et al. Comparative effects of nebivolol and metoprolol on red cell distribution width and neutrophil/lymphocyte ratio in patients with newly diagnosed essential hypertension. J Cardiovasc Pharmacol. 2013; 62(4): 388-393. doi: 10.1097/FJC.0b013e31829f716a

Ragab Abdelsalam Mahfouz, MD

Professor
Department of Cardiology
Faculty of Medicine
Zagazig University
Al Modir Street, Markaz El-Zakazik
Ash Sharqia Governorate 44516, Egypt

BiographyResearch InterestScientific ActivitiesPublications
Education

• MBBCH: December 1985
• Master Degree in Cardiology: December 1989
• MD degree in Cardiology: November 1994


Professional Experience

• Resident of cardiology in cardiology department Zagazig University Hospital: 11/3/1987-30/9/1990
• Assistant lecturer of cardiology: 31/8/1991-17/4/1995
• Lecturer of cardiology: 18/4/1995- 29/5/2000
• Assistant professor of cardiology: 29/5/2000-2/5/2005
• Professor of cardiology: 3/5/2005-Present

His research interests include: Structural heart disease (congenital heart disease and Balloon valvuloplasrty), in addition to basics and research.

• Member of the Permanent Egyptian universities Promotion committees (EUPC)
• Highly qualified in Echocardiography with introduction of specific maneuvers and scores in some cardiac diseases
• Introduction of different lectures in cardiology in different cardiac conferences in Egypt
• Introduction of teaching programs in clinical cardiology and echocardiography in several hospitals related to the Ministry of Health
• Introduction of all cardiology subjects for under and post-gradient students in a simplified power point data show lectures
• Reviewer of more than 400 scientific papers
• Supervision of more than 95 MD and master thesis
• Discussion of more than 120 MD and master thesis
• The founder and chief of congenital unite in cardiology department, zagazig University hospital
• The founder and the academic leader of congenital unite in Al-ahrar teaching hospital (Ministry of health) in Zagazig


Cardiac Catheterization:

• Diagnostic catheterization
• Interventional catheterization for coronary artery diseases, congenital heart diseases and valvuloplasty
• High experience in performing PBMV (More than 2700 percutaneous Mitral Balloon Valvuloplasty)
• The most interest on: Structural heart disease (congenital heart disease and Balloon valvuloplasrty), in addition to `basics and research

There are more than 90 papers published (Internationally and nationally) in different cardiology fields, for examples: in Rheumatic fever, Echocardiography, Catheterizations, Coronary artery diseases and others.


Some Recent Publications

1. Mahfouz RA, El Zayat A, Yousry A. Left ventricular restrictive filling pattern and the presence of contractile reserve in patients with low-flow/low-gradient severe aortic stenosis. Echocardiography. 2015; 32(1): 65-70. doi: 10.1111/echo.12586
2. Mahfouz RA, Alzaiat A, Yousry A. Relationship of epicardial fat thickness with endothelial and cardiac functions in children with family history of type 2 diabetes mellitus. Echocardiography. 2015; 32: 28-33. doi: 10.1111/echo.12595
3. Mahfouz RA. Relation of left atrial stiffness to insulin resistance in obese children: doppler strain imaging study. Echocardiography. 2015.
4. Mahfouz RA, Alzaiat A, Gad M. Association of aortic stiffness to brain natriuretic peptide in children before and after device closure of patent ductus arteriosus. Journal of the Saudi Heart Association. 2015; 27(1): 23-30. doi: 10.1016/j.jsha.2014.06.001
5. Mahfouz RA, Dewedar A, Elzayat A, Elawady W. Usefulness of the global echo-doppler score (GEDS) in selection of patients with mitral stenosis for percutaneous balloon mitral valvuloplasty. Cardiology Journal. 2014. doi: 10.5603/CJ.a2013.0086
6. Mahfouz RA, Mostafa T, Fahmy DS. Impact of the neutrophil-to-lymphocyte ratio on coronary flow reserve and incipient myocardial dysfunction in patients with psoriatic arthritis. J Arthritis. 2014; 3: 119.
7. Mahfouz RA, Elawady W, Abdu M, Salem A. Associations of fractional pulse pressure to aortic stiffness and their impact on diastolic function and coronary flow reserve in asymptomatic diabetic patients with normal coronary angiography. Cardiol J. 2013; 20(6): 605-611. doi: 10.5603/CJ.2013.0160
8. Mahfouz RA, Elawady W, HosseinE, Yosri A. Impact of atrioventricular compliance on clinical outcome of patients undergoing successful percutaneous balloon mitral valvuloplasty. Echocardiography. 2013; 30: 1187-1193. doi: 10.1111/echo.12256
9. Mahfouz RA. Relation of coronary flow reserve and diastolic function to fractional pulse pressure in hypertensive patients. Echocardiography. 2013; 30: 1084-1090. doi: 10.1111/echo.12241
10. Mahfouz RA, Abdulmoneim A, Abduo M, Elawady W. The relation of aortic stiffness and in-stent restenosis in patients undergoing percutaneous coronary stenting. Echocardiography. 2013; 30(5): 582-587. doi: 10.1111/echo.12078
11. Mahfouz RA, Dewedar AE. The prognostic impact of P wave dispersion in prediction of clinical outcome after percutaneous balloon mitarl valvuloplasty in patients with mitral stenosis and sinus rhythm. World Journal of Cardiovascular Diseases. 2013; 3: 82-89. doi: 10.4236/wjcd.2013.31014
12. Mahfouz RA, Eldawei K, Elawady W, Dewedar A. Biomarkers score for patients with mitral stenosis: a useful conjunction with Wilkins’s score for early intervention. Heart Res Open J. 2015; 2(4): 118-125. doi: 10.17140/HROJ-2-121