Gynecology and Obstetrics Research - Open Journal
Loch Haven Obgyn Group
Department of Obstetrics and Gynecology
Florida Hospital Graduate Medical Education
Winter Park, Florida, USA
2015 – present American institute of ultrasound in medicine
2015 – present American society for reproductive medicine
2014 – present Society for reproductive surgeons
2014 – present Association of professors of gynecology and obstetrics
2012 – 2014 North carolina medical society
2012 – 2014 North carolina obstetrical and gynecological society
2012 – present American society for colposcopy and cervical pathology
2008 – present American college of obstetricians and gynecologists
Leader and Innovator
2008 – present Feed a family foundation, inc., vice president / co-founder
2001 – 2002 Spectrum dance company, co-founder
1999 – 2008 Power over panic foundation, inc., president / founder
Honors and Awards
2009 Scholarly concentration in research, university of south florida college of med
2006 National allman medical school scholarship award, miss america organization
2004 National community service award, miss america organization
2004 Platform interview award and top 10 finalist, miss florida organization
2004 Kressley platform interview award, miss orlando organization
2004 Miss orlando, miss orlando organization
2003 Newcomer interview award, miss florida organization
2003 Miss winter park, miss winter park organization
2003 Hemphill community service award, miss orlando organization
2002 Hemphill community service award, miss orlando organization
2001 Hemphill community service award, miss orlando organization
2001 Graduated cum laude honors, rollins college
2001 Psi chi national psychology honor society, rollins college
Worley, AV, Ahmed, SM, Tucci, V, Moukaddam, N, Lee, S, Shah, A, and Wilson, MP, ‘Depression and Suicidal Ideation in Pregnancy,’ International Journal of Current Research, 2016, December 30, 8(12):43715-43730.
Moiz, S, Moudkaddam, N, Worley, AV, Shah, A, Tucci, V, ‘Teratogenic Potential of Commonly Prescribed Psychotrophic Drugs,’ Medical Journal of Obstetrics and Gynecology, 2016, November 19, 4(4):1091, 1-9.
Lee, S, Tucci, V, Moukaddam, N, Worley, AV, and Shah, A, ‘Pregnant and Virtually Abandoned: The Multiple Hurdles of Medically Clearing and Admitting a Pregnant Patient to an Inpatient Psychiatric Unit,’ Journal of Psychiatry and Mental Health, 2016, June, 1(1).
Tatum, WO, Worley, AV, and Selenica, ML, ‘Disobedience and Driving in Patients with Epilepsy,’ Epilepsy and Behavior, 2012, January, 23(1):30-35.
Peters, A, Verderosa, A, & Sethares, C, ‘The Neuroglial Population in the Primary Visual Cortex of the Aging Rhesus Monkey,’ Glia, 2008, August 15, 56(11): 1151-1161.
Worley, AV and Berga, SL, ‘Non-Pharmacologic Approaches to Stress-Induced Infertility,’ The Handbook of Behavioral Medicine, Wiley-Blackwell 2013.
Verderosa, A, ‘Leaving a Legacy: Tax Deductions and Charitable Intent,’ Free Flight Society Magazine, Vol March, 2008.
Verderosa, A, ‘Leaving a Legacy: Controlling Your Donations,’ Free Flight Society Magazine, Vol February, 2008.
Verderosa, A, ‘Leaving a Legacy: US Family Foundation,’ Free Flight Society Magazine, Vol November, 2007.
Verderosa, A, ‘5-HT versus GABA Agonists and Their Effects on the Treatment of Panic Disorder in Humans,’ Graduate Thesis, Boston University School of Medicine, 2004.
Verderosa, A, ‘A Journey Through My Mind: A Collection of Works,’ November, 1997.
Verderosa, A, ‘Curing All Ills,’ Australian Documentary, April, 2004.
MANUSCRIPTS IN PREPARATION
Worley, AV, Willis, MY, and Roberts, CP, ‘Posterior Colpotomy: A Novel Approach to Cervico-Vaginal Anastomosis in a Case of Hypoplastic Cervix with Partial Vaginal Agenesis.’ (submitted)
Worley, AV, Selenica, ML, and Tatum, WO, ‘The Medical, Psychological, and Legal Impact of Seizures and Driving: A Survey on Patient Compliance and Knowledge of the Law.’ (submitted)
Worley, AV and Mertz, H, ‘Fetal to Maternal Transmission of Cancer: The First Case Ever Reported.’
Worley, AV, ‘Recurrent Myocardial Infarctions with Menstruation: A Case Report.’
Associate Professor and Consultant of Obstetrics and Gynaecology
Faculty of Medicine
Oula, Giza, Giza Governorate, Egypt
Education and Training
• 1977-1982: Canal Primary school, Maadi, Cairo, Egypt
• 1983- 1987: Aboayoub Elansary Intermediate School, Kuwait
• 1988- 1990: Maadi Secondary School, Maadi, Cairo, Egypt
• 1991- 1997: Medical Student, Faculty of medicine - Cairo University
• 1999- 2001: MSc, Ob/Gyn Student, Faculty of medicine - Cairo University
• 2002- 2005: MD, Ob/Gyn Student, Faculty of medicine - Cairo University
• House officer in Cairo University hospitals for one year from 1/3/1998 to 28/2/1999
• Resident doctor (Registrar) of obstetrics and gynaecology in obstetrics and gynaecology Hospital, Faculty of medicine, Cairo University Hospitals for 3 years from 16/9/1999 to 15/9/2002
• Instructor and Specialist of obstetrics and gynaecology in obstetrics and gynaecology department and Hospital - Faculty of medicine, Cairo University for 8 months from 11/3/2003 to 16/11/2003
• Lecturer and Specialist of obstetrics and gynaecology in obstetrics and gynaecology department and Hospital - Faculty of medicine, Cairo University for 22 months from 17/11/2003 to 27/9/2005
• Assistant Professor and Specialist of obstetrics and gynaecology in obstetrics and gynaecology department and Hospital, Faculty of medicine - Cairo University for 5 years from 28/9/2005 to 26/10/2010
• Associate Professor and Consultant of obstetrics and gynaecology obstetrics in obstetrics and gynaecology department and Hospital, Faculty of medicine - Cairo University from 27/10/2010 to Present
• Staff member of the Oncogynaecology unit of Obstetrics and Gynaecology Department, Faculty of medicine- Cairo University
• Consultant of assisted reproduction and IVF- Ganna IVF Hospital
• Consultant of high risk obstetrics, new Kasr El-Eini Specialized Hospital
• Teaching the undergraduate Obstetrics and gynaecology course for medical students in Obstetrics and Gynaecology Department, Faculty of medicine- Cairo University from 2003 to Present
• Teaching the undergraduate Obstetrics and gynaecology course for the medical student of 6th of October University between 2004 and 2010
• Teaching the undergraduate Obstetrics and gynaecology course for the students of the nurses technical institute- Cairo university between 2005 and 2010
• Teaching the undergraduate Obstetrics and gynaecology course for the students of the nurses technical school- Cairo university between 2005 and 2010
• Teaching the clinical postgraduate Obstetrics and gynaecology course for the MSc students from 2007 to Present
• Trainer of hysteroscopy in the workshops of diagnostic and operative hysteroscopy of the department of gynaecology and obstetrics- Cairo University from 2007 to Present
• Trainer of basic and advanced ultrasound in the workshops of basic and advanced ultrasound of the department of gynaecology and obstetrics- Cairo University between 2005 and 2010
• Trainer of basic and advanced ultrasound in the basic and advanced ultrasound courses of the Egyptian Medical Syndicate between 2005 and 2006
• Supervision of twenty four master degree thesis and four MD thesis
His research interests include: High risk obstetrics management, Vaginal surgeries, Gynecologic Endocrinology, Assisted reproduction techniques, Laparoscopy and hysteroscopy, Colposcopy, Trans-abdominal and trans-vaginal Pelvic Ultrasound and ultrasound guided procedures.
Publications in Indexed Journals
1. El-Sherbiny W, El-Mazny A, Abou-Salem N, Mostafa WS. The diagnostic accuracy of two- versus three-dimensional sonohysterography for evaluation of the uterine cavity in the reproductive age. J Minim Invasive Gynecol. 2015; 22(1): 127-131. doi: 10.1016/j.jmig.2014.08.779
2. Aal AAA, Attia SS, Hanafy NA, et al. molecular diagnosis of toxoplasmosis in non immune pregnant females. Maced J Med Sci. 2014; 7(3): 415-420. doi: 10.3889/MJMS.1857-5773.2014.0425
3. Salem M, Kamal S, El Sherbiny W, Abdel Aal AA. Flow cytometric assessment of endothelial and platelet microparticles in preeclampsia and their relation to disease severity and Doppler parameters. Hematology. 2014. doi: 10.1179/1607845414Y.0000000178
4. Elmahgoub IR, Afify RA, Abdel Aal AA, El-Sherbiny WS. Prevalence of coagulation factor XIII and plasminogen activator inhibitor-1 gene polymorphisms among Egyptian women suffering from unexplained primary recurrent miscarriage. J Reprod Immunol. 2014; 103: 18-22. doi: 10.1016/j.jri.2014.02.007
5. El-Sherbiny W, Nasr AS, Soliman A. Endothelial nitric oxide synthase (eNOS) (Glu298Asp) and urotensin II (UTS2 S89N) gene polymorphisms in preeclampsia: prediction and correlation with severity in Egyptian females. Hypertension in Pregnancy. 2013; 32(3): 292-303. doi: 10.3109/10641955.2013.806539
6. El-Sherbiny W, Saber W, Askalany A, El-Daly A, Sleem A. Effect of intra-abdominal instillation of lidocaine during minor laparoscopic procedures. Int J Gynaecol Obstet. 2009; 106(3): 213-215. doi: 10.1016/j.ijgo.2009.04.016
7. Abou-Salem N, El-Mazny A, El-Sherbiny W. Value of 3-dimensional sonohysterography for detection of intrauterine lesions in women with abnormal uterine bleeding. Journal of Minimally Invasive Gynecology. 2010; 17(2): 200-204. doi: 10.1016/j.jmig.2009.12.010
8. El-Mazny A, Abou-Salem N, El-Sherbiny W, El-Mazny AH. Insulin resistance, dyslipidemia, and metabolic syndrome in women with polycystic ovary syndrome. International Journal of Gynecology and Obstetrics. 2010; 109(3): 239-241. doi: 10.1016/j.ijgo.2010.01.014
9. El-Mazny A, Abou-Salem N, El-Sherbiny W, Saber W. Outpatient Hysteroscopy: A routine investigation prior to assisted reproductive techniques? Fertil Steril. 2011; 95(1): 272-276. doi: 10.1016/j.fertnstert.2010.06.033
10. El-Sherbiny W, Nasr A. Value of 3-dimensional sonohysterography in infertility work up. J Minim Invasive Gynecol. 2011; 18(1): 54-58. doi: 10.1016/j.jmig.2010.08.697
11. El-Sherbiny W, Soliman A, El-Mazny A. Elevated serum-soluble Fas in preeclampsia: correlation with clinical, laboratory, and Doppler parameters. Hypertens Pregnancy. 2011; 30(2): 221-230. doi: 10.3109/10641955.2010.544804
12. El Sherbiny WS, Nasr A, Soliman A. Placental protein 13 as an early predictor in egyptian patients with preeclampsia, correlation to risk, and association with outcome. J Investig Med. 2012; 60(5): 818-822. doi: 10.231/JIM.0b013e31824e9a68
13. El-Sherbiny W, Nasr A, Soliman A. Metalloprotease (ADAM12-S) as a predictor of preeclampsia: correlation with severity, maternal complications, fetal outcome, and doppler parameters. Hypertens Pregnancy. 2012; 31(4): 442-450. doi: 10.3109/10641955.2012.690059
14. El-Sherbiny W, Al-Inany H, Ibrahim M, Harb H. Antimullerian hormone as a predictor of ovarian reserve after laparoscopic ovarian drilling. Human Reproduction. 2010; 25: I83-I84.
Publications in Other Periodicals
15. Shawki O, El-Sherbiny W, Saber W, Askalany A, El-Daly A. Treatment of heavy menstrual bleeding associated with uterine leiomyoma with the levonorgestrel-releasing intrauterine system. Gynecol Surgery journal. 2009; 6(4): 331-337. doi: 10.1007/s10397-009-0479-1
16. Motawe M, Abuleil Z, Shaaban Y, Azab H, Alsaeed M, El-Sherbiny W. Assessment of endometrial receptivity in unexplained infertility by Doppler ultrasound and interleukin-1. The Middle East Fertility Society Journal. 2008; 13(3).
17. El-Sherbiny W, Farouk A, El-Badry M, El-Mekawy M, El-Inany H. Footwear and postural changes in the third trimester of pregnancy. Anatolian Journal of Obstetrics & Gynecology. 2010; 2(2).
18. El-Sherbiny W, Kamal S. Circulating microparticles in preeclampsia. Anatolian Journal of Obstetrics & Gynecology. 2009; 1(4).
19. Al-Sharkawy SH, Amer M, Motawe M, Al-Shahed M, El-Sherbiny W. A comparative study of mixed urinary gonadotrophins regimens. The Medical Journal of Cairo University. 2008; 76(suppl 4).
20. Ali E, Bousely T, Yassin R, El-Sherbiny W, Thabet S. New attempts in diagnosing and managing the endometrial mucosal factor in unexplained infertility. Scientific Medical Journal (Egypt). 2009; 21(1).
21. Kilani Z, Shaban M, Haj Hassan L, El-Sherbiny W. Dehydroepiandrosterone administration to women during ovarian stimulation is detrimental to IVF outcome. Kajog. 2010; 1(3): 101-106.
22. Aletaibi F, El-Sherbiny W, Nasr A. Adding GnRH antagonist in iui cycles decreased the complications and didnt affect the outcome in women with PCOS. Evidence Based Womens Health Journal. 2011; 1(1).
23. El-Kashif A, Kamal M, Fathy M, El-Sherbiny W. Serum endoglin and hepatocyte growth factor; correlation with the clinical presentation of breast cancer patients. PAJO. 2010; 3(4): 14-19.
Professor of Obstetrics & Gynecology
Faculty of Medicine
Syut, Al Hamraa Ath Thaneyah
Qesm Than Asyut, Assiut Governorate, Egypt
• 1991: Msc (Gynaecological Endoscopy- Hysteroscopy), Faculty of Medicine, Assiut University, Assiut, Egypt
• 1996: MD (Reproductive Endocrinology), Faculty of Medicine, Assiut University, Assiut, Egypt
Administrative and Academic Appointments
• 3/1991-2/1992: Demonstrator, Faculty of Medicine, Assiut University, Egypt
• 3/1992-2/1997: Assistant Lecturer, Faculty of Medicine, Assiut University, Egypt
• 3/1997-2002: Lecturer, Faculty of Medicine, Assiut University, Egypt
• 3/2002-8/2006: Assistant professor, Faculty of Medicine, Assiut University, Egypt
• 8/2006-7/2009: Associate Professor, King Khalid University, Abha, Saudi Arabia
• 9/2009-6/2013: Full Professor, King Khalid University, Abha, Saudi Arabia
• 10/2007-Present: Full Professor, Faculty of Medicine, Assiut University, Egypt
His research interests include: Gynaecology and Obstetrics.
• A member of the Egyptian Medical Syndicate, since March 1988
• A member of the Egyptian Society of Obstetrics and Gynaecology, since April 1991
• A member of the Egyptian Fertility Care Society (EFCS), since June 1993
• A member of the Middle East Fertility Society (MEFS), since January 2014
• Member of Assiut Medical Committee of continuous Medical Education in collaboration with the Minstery of Health, since 1997, Egypt
• Member in the local committee of infection control at Assiut university Hospitals, since 2003, Egypt
• Member of the local medical committee for continuous Medical Education at Abha maternity hospital (in collaboration with the Minstery of Health), 2006-2011, ASSIR region, Saudi Arabia
1. Shaamash AH, Alshahrani MS, Awadalla NJ, Hakami HW. Falling in serum b human chorionic gonadotropin levels between days 1 and 7 as a new protocolto predict successful single-dose of methotrexatetherapy for ectopic pregnancy. Middle East Fertil Soc J. 2014. doi: 10.1016/j .mefs.2014.11.001
2. Shaamash A, Houshimi W, Elkanzi E, Zakaria A. Abortion hysterectomy at Abortion hysterectomy at 11 weeks’ gestation due to undiagnosed placenta accreta (PA): A case report and a mini review of literatures. Middle East Fertility Society Journal. 2014; 19(3): 147-152. doi: 10.1016/j.mefs.2014.03.005
3. Eskandar MA, Al-Shahrani M, Shaamasha A, El-Emain M, Al-Ahmad M, Payodon B. Early maternal serum β-human chorionic gonadotropin measurements after icsi in the prediction of long-term pregnancy outcomes: a retrospective cohort analysis. J Clin Med Res. 2011; 3(1): 30-35. doi: 10.4021/jocmr477e
4. Shaamash AH, Shaaban MM, Sayed GH, Eskandar MA. Use of the lng-ius postpartum and during lactation. Gynaecology Forum. 2008; 13(1): 23-28.
5. Eskandar M, Almushait MA, Shammash A, et al. A prospective comparison of two commercially available media for intrauterine insemination. Saudi Journal of Obstetrics and Gynecology. 2007; 7(2): 1428H.
6. Shaamash AH, Ahmed AGM, Latef MMA, Abdullah SA. Routine postpartum ultrasonography in the prediction of puerperal uterine complications. IJGO. 2007; 98(2): 93-99. doi: 10.1016/j.ijgo.2007.03.042
7. Shaamash AH, Sayed GH, Hussien MM, Shaaban MM. A comparative study of the levonorgestrel-releasing intrauterine system mirena(r) versus the copper t380a intrauterine device during lactation: breast-feeding performance, infant growth and infant development. Contraception. 2005; 72(5): 346-351. doi: 10.1016/j.contraception.2005.04.004
8. Shaamash AH, Zakhari MM. Increased serum levels of nitric oxide metabolites among users of levonorgestrel-releasing implants [corrected] a possible role in progestin-induced bleeding. Hum Reprod. 2005; 20(1): 302-306. doi: 10.1093/humrep/deh761
9. Shaamash AH, Salem HT, Shaaban MM, Ghaneima SA, Helal SR. Effect of uniplant on liver function in egyptian women with asymptomatic hepatitis b virus infection. African Journal of Reproductive Health. 2005; 9(1): 24-31.
10. Shaamash AH, Sayed EH. Prediction of successful menorrhagia treatment after thermal balloon endometrial ablation. J Obstet Gynaecol Res. 2004; 30(3): 210-216. doi: 10.1111/j.1447-0756.2004.00189.x
11. Shaamash AH, Mohamed IS, Hasan MA, Ibrahim MA. Preconceptional immunity to cytomegalovirus and the risk of symptomatic congenital infection. Int J Gynaecol Obstet. 2003; 83(2): 199-201. doi: 10.1016/S0020-7292(03)00158-9
12. Shaamash AH, Elsonosy ED, Zakhari MM, Radwan SH, El-Dien HM. Placental nitric oxide synthase (NOS) activity and nitric oxide (NO) production in normal pregnancy, pre-eclampsia and eclampsia. Int J Gynaecol Obstet. 2001; 72(2): 127-133. doi: 10.1016/S0020-7292(00)00314-3
13. Shaamash AH, Elsnosy ED, Makhlouf AM, Zakhari MM, Ibrahim OA, ELdien HM. Maternal and fetal serum nitric oxide (NO) concentrations in normal pregnancy, pre-eclampsia and eclampsia. Int J Gynaecol Obstet. 2000; 68(3): 207-214. doi: 10.1016/S0020-7292(99)00213-1
Department of Obstetrics and Gynaecology
Elsalam Street, Eloboor, Maghagha, El Minya , Egypt
Dr. El Gelany graduated from Minia University, Egypt in 1998 with grade excellent with honour in his MBBCh and got his Master degree of Obstetrics & Gynaecology, Minia University, El Minya, Egypt, 2003, grade excellent. Then he completed his Doctorate in Reproductive and Developmental Unit at the University of Sheffield, UK in conjunction with Minia College of Medicine, Egypt through a joint research project in 2008.After his analytical study of different serum markers related to recurrent miscarriage and correlation with Doppler velocimetry, he went to extend his practice in the field of reproductive and sexual health as he noticed a gap in the targeted population. Where he directed his research to this hidden field in his community. This led to the development of improvement of community awareness to different health problems as antenatal classes sessions, reproductive and sexual health awareness courses. Due to his efforts in raising the awareness of risks of postpartum hemorrhage, he won the FIGO fellowship in Rome 2012. Another period of experience had gained during his FIGO fellowship in Bologna University, Italy in the Department of Obstetrics and Prenatal Medicine.
Dr. El Gelany is currently Assistant Professor & Researcher of Obstetrics and Gynaecology, and Consultant at Minia Maternity & Children University Hospital, Minia University Egypt. Also he is serving as Clinical Consultant at the Fetomaternal unit. He is recognised internationally by his research in the area of reproductive health and community research.
His research interests include: Reproductive health, Miscarriage, High risk pregnancy, Feto- maternal Dopplers, Community and health professional awareness, Reduction of maternal morbidity and mortality.
• Joint fellowship to the University of Sheffield, UK (2005-2008)
• FIGO fellowship, Bologna university, Italy (2012)
MEMBERSHIPS IN PROFESSIONAL SOCIETIES
• Trainee RCOG
• Egyptian fertility sterility society
• Egyptian Obstetrics & Gynaecologist Society
• Human parturition group at the University of Sheffield during his MD study
• British Maternofetal medicine society (BMFMS)
1. El Gelany S, Moussa O. Reproductive health awareness among educated young women in Egypt. International Journal of Gynecology and Obstetrics. 2013; 120(2013): 23-26. doi: http://dx.doi.org/10.1016/j.ijgo.2012.07.027
2. Ahmad AK, Deen AMSA, AL-Sagheer GA, El Gelany S, Hamdy L. Study the Effect of Hypertriglyceridemia and Hyperglycemia on the Outcome of Pregnancy in Diabetic and Non diabetic women. The Journal of Egptian society of endocrinology and obesity. 2013; 3(1).
3. Hassanin AAM, Abdelmeged AN, El Gelany S. Management of postoperative nausea and vomiting by bilateral application of magnetic acupressure in patients undergoing gynecologicallaparoscopy. Ain Shams journal of anaesthesia. 2013.
4. El Gelany S, Abdel-Megeed A, Khalifa H. Fertility options for Muslim people: acceptability & awareness among clients and health service providers. Oral presentation at 26th eshre meeting & the journal of Egyptian fertility and sterility. 2011.
5. El Gelany S, Abdelmegeed AN.A suggested protocol for home management of PUL. The journal of Egyptian fertility and sterility society. 2011.
6. Anumba DO, El Gelany S, Elliott SL, Li TC. Serum relaxin levels are reduced in pregnant women with a history of recurrent miscarriage, and correlate with maternal uterine artery Doppler indices in first trimester. European Journal of Obstetrics & Gynecology and Reproductive Biology. 2009. doi: 10.1016/j.ejogrb.2009.07.008
7. Anumba DOC, El Gelany S, Elliott SL, Li TC. Circulating levels of matrix proteases and their inhibitors in pregnant women with and without a history of recurrent pregnancy loss. Reproductive Biology and Endocrinology. 2010; 8: 62. doi: 10.1186/1477-7827-8-62
8. El-maqsoud NRA, El Gelany S. Differential Expression Patterns of PTEN in Cyclic, Hyperplastic and Malignant Endometrium: Its Relation with ER, PR and Clinic pathological Parameters. Journal of the Egyptian Nat. Cancer Inst. 2009; 21(4): 323-331.
9. Gelany SE, Mansour MM, Hassan MM. The Three delays of maternal mortality in a public-sector tertiary teaching hospital: is there a paradigm shift? Gynecol Obstet Res Open J. 2015; 2(2): 52-56. doi: 10.17140/GOROJ-2-112
Department of Pediatric
Gynecological, Microbiological and Biomedical Science
University of Messina
Via C. Valeria 1, 98125 Messina, Italy
Dr. Laganà, from the Department of Pediatric, Gynecological, Microbiological and Biomedical Sciences of the University of Messina, Italy.
Currently, he is the Member of the Italian Association of Endometriosis Expert Panel, In-Training Member of the Society for Reproductive Investigation, Regular Member of the European Society of Human Reproduction and Embryology, of the International Society of Gynecological Endocrinology, of the Italian Society of Gynecology of Childhood and Adolescence, of the Italian Society of Gynaecological Endoscopy and of Giorgio Pardi Foundations professional research team.
His research interests include: Endometriosis, Reproductive Immunology, T cell subsets, Chronic pelvic pain, Organogenesis and Genetic of Mullerian-Derived structures, Gynecological endocrinology, Polycystic ovarian syndrome (PCOS), Laparoscopy, Hysteroscopy and Minimally invasive surgery in ob/gyn.
• Medela award 2012 for the best proposed research ideas, during Agorà SIMP (Italian Society of Maternal-Fetal Medicine National Congress)
• Buonasanità special award 2013 from Centro Studi La Fenice
• Glasgow City Councils Award, during the the 23rd European Congress of Obstetrcis and Gynaecology (Glasgow, Scotland. 7-10 May 2014)
• In-Training Member of the Society for Reproductive Investigation
• Member of European Society of Human Reproduction and Embryology (ESHRE)
• Expert Panel of the Italian Association of Endometriosis
• International Society of Gynecological Endocrinology
• Italian Society of Gynecology of Childhood and Adolescence (SIGIA)
• Italian Society of Gynaecological Endoscopy (SEGI)
1. David E, Albani A, Laganà AS. Congenital hypopituitarisms: genetics, clinical aspects and instrumental diagnosis. Italian Journal of Genetic and Pediatric Immunology. 2011.
2. David E, Samà L, Bertè G, Albani A, Bucolo M, Laganà AS. Mayer- Rokitansky syndrome: genetics, clinical, radiological aspects and therapeutic perspectives. Italian Journal of Genetic and Pediatric Immunology. 2011.
3. Sturlese E, Salmeri FM, et al. Dysregulation of the Fas/FasL system in mononuclear cells recovered from peritoneal fluid of women with endometriosis. J Reprod Immunol. 2011; 92(1-2): 74-81. doi: 10.1016/j.jri.2011.08.005
4. De Dominici R, Retto G, Palmara V, Laganà AS, Sturlese E. Outcome riproduttivo dopo gravidanza tubarica. Proceedings of the third national congress of the Italian Federation of Obstetrics and Gynecology, second national congress of the Italian Association of In-Training Gynecologists. The charm of modern gynecology between health and safety of the woman: updates and needs. 2012.
5. Laganà AS, Sturlese E, Retto G, Retto A, De Dominici RSelective episiotomy and prevention of perineal tears during childbirth spontaneous unanalisi retrospective. Proceedings of the third national congress of the Italian Federation of Obstetrics and Gynecology, second national congress of the Italian Association of In-Training Gynecologists The charm of modern gynecology between health and safety of the woman: updates and needs. 2012.
6. Laganà AS, Salmeri FM, Retto G, et al. Stage-related changes of peritoneal soluble TNFα and TNFR1 and TNFR2 in cells recovered from peritoneal fluid of women with endometriosis. J Reprod Immunol. 2012; 94 (1): 94-95. doi: 10.1016/j.jri.2012.03.417
7. Laganà AS, Santoro G, Sturlese E, et al. Laparoscopic management of coexistent live ectopic pregnancy and lithokeliphopedion. 3rd Congress of Serbian Anatomical Society Abstract Book. Nis, Serbia. 2012.
8. Giacobbe A, Grasso R, Interdonato ML, et al. An unusual form of mirror syndrome: a case report. J Matern Fetal Neonatal Med. 2013; 26(3): 313-315. doi: 10.3109/14767058.2012.722734
9. Laganà AS, Pizzo A, DAscola A, et al. May analysis of Th1, Th2, Th17 and Treg cells in peripheral blood of women with early pregnancy (11-13 weeks) be predictive of risk of developing fetal intrauterine growth restriction? Agorà SIMP (Italian Society of Maternal-Fetal Medicine National Congress). Genoa, Italy. 2012.
10. Laganà AS, DAscola A, Salmeri FM, et al. mRNA expression of Foxp3 and RORc transcription factors and of IL-10 and IL-17A cytokines in ovarian endometrioma of women with endometriosis. Journal of Endometriosis. 2012; 4(4): 227-228.
11. Pizzo A, Laganà AS, Sturlese E, Retto G, Retto A, De Dominici R, Puzzolo D. Mayer-Rokitansky-Kuster-Hauser Syndrome: Embryology, Genetics and Clinical and Surgical Treatment. ISRN Obstet Gynecol. 2013; 2013: 628717. doi: 10.1155/2013/628717
12. Pizzo A, Laganà AS, Borrielli I, Dugo N. Complete androgen insensitivity syndrome: a rare case of disorder of sex development. Case Rep Obstet Gynecol. 2013; 2013: 232696. doi: 10.1155/2013/232696
13. Leonardi V, Merlino M, Greco D, et al. Psychosocial vulnerability factors in Postpartum depression. Journal of Psychopatholoy. (17th Congress of Italian Society of Psychopathology Abstract Book). 2013; 19(S1): 14-15.
14. Laganà AS, Pizzo A, DAscola A, et al. mRNA expression of transcription factors and cytokines in immune cells of ovarian endometrioma from women with endometriosis. Reproductive Sciences. 2013; 20(3 Supp): 146-147.
15. Triolo O, Laganà AS, Sturlese E. Chronic Pelvic Pain in Endometriosis: An Overview. J Clin Med Res. 2013; 5(3): 153-163. doi: 10.4021/jocmr1288w
16. Butticè S, Laganà AS, Barresi V, et al. Lumbar Ureteral Stenosis due to Endometriosis: Our Experience and Review of the Literature. Case Rep Urol. 2013; 2013: 812475. doi: 10.1155/2013/812475
17. Laganà AS, Borrielli I, Barbaro L, Pizzo A. Myo-Inositol Vs D-Chiro-Inositol: preliminary data on the comparison between their effects on ovarian function and metabolic factors in women with PCOS. Proceedings of The World Congress on Building Consensus out of Controversies in Gynecology, Infertility and Perinatology (BCGIP-cogi). Istanbul, Turkey. 2013.
18. Laganà AS, Sturlese E, Retto G, Sofo V, Triolo O. Interplay between Misplaced Müllerian-Derived Stem Cells and Peritoneal Immune Dysregulation in the Pathogenesis of Endometriosis. Obstet Gynecol Int. 2013; 2013: 527041. doi: 10.1155/2013/527041
19. Leonardi V, Bruno A, Merlino M, et al. Psychosocial vulnerability to postpartum depression. Proceedings of the 21st World Congress for Social Psychiatry. Lisbon, Portugal. 2013.
20. Merlino M, Leonardi V, Greco D, et al. Sub threshold psychiatric symptoms and post-partum mood disorders. Proceedings of the 21st World Congress for Social Psychiatry. Lisbon, Portugal. 2013. 21. Laganà AS, Salmeri FM, Sofo V, et al. Obstacles and Pitfalls of Endometriosis-Related Chronic Pelvic Pain Management: Trying to Alleviate the Burden. J Pain Relief. 2013(2): 123.
22. Burgio MA, Laganà AS, Sicilia A, et al. Preliminary data on the evaluation of the recovery and quality dellattività female sex in the post-partum, in relation to the different methods of completing the delivery. Urogynaecologia International Journal. 2013; 27(2): 125-127.
23. Laganà AS, Cucinella G, Calagna G, et al. Control of symptoms relapse after conservative surgery for endometriosis: advantages of using dienogest plus estradiol valerate. Journal of Endometriosis. 2013; 5(Suppl 1): S20-S21.
24. Pizzo A, Laganà AS, Barbaro L. Comparison between effects of myo-inositol and d-chiro-inositol on ovarian function and metabolic factors in women with PCOS. Gynecol Endocrinol. 2014. doi: 10.3109/09513590.2013.860120
25. Laganà AS, Pizzo A. Know your Enemy: The Rationale of Using Inositol in the Treatment of Polycystic Ovary Syndrome. Endocrinol Metab Synd. 2013; 2: e121.
26. Corrado F, DAnna R, Laganà AS, Di Benedetto A. Abnormal glucose tolerance later in life in women affected by glucose intolerance during pregnancy. J Obstet Gynaecol. 2014; 34(2): 123-126. doi: 10.3109/01443615.2013.841658
27. Laganà AS, Barbaro L, Pizzo A. Preliminary data on ovarian function and metabolic factors in women affected by polycystic ovary syndrome after treatment with D-Chiro-Inositol. Giorn It Ost Gin. 2014; 36(1): 178.
28. Laganà AS, Perino A, Salmeri FM, et al. mRNA Expression of FoxP3 and IL-10 in Deciduas from Patients with Unexplained Early Recurrent Miscarriage. Reprod Sci. 2014; 21(3 Supp): 327A-328A.
29. Santoro G, Laganà AS, Sturlese E, Giacobbe V, Retto A, Palmara V. Developmental and Clinical Overview of Lithopaidion. Gynecol Obstet Invest. 2014; 78(4): 213-223. doi: 10.1159/000358828
30. Cartabellotta A, Laganà AS, Bartoletti R. Diagnosis and therapy dellincontinenza female urinary. Evidence. 2014; 6(3): e1000074.
31. Laganà AS, Palmara V, Pizzo A, et al. Desogestrel versus danazol as preoperative treatment for hysteroscopic surgery: preliminary data. Proceedings of the 23rd European Congress of Obstetrics and Gynaecology. Glasgow, Scotland. 2014.
32. Butticè S, Laganà AS, Mucciardi G, et al. Different pattern of pelvic ureteral endometriosis. What is the best treatment? Preliminary results of a retrospective analysis. Proceedings of the 23rd European Congress of Obstetrics and Gynaecology. Glasgow, Scotland. 2014.
33. Salmeri FM, Laganà AS, Sofo V, et al. Behavior of Tumor Necrosis Factor-α and Tumor Necrosis Factor Receptor 1/Tumor Necrosis Factor Receptor 2 System in Mononuclear Cells Recovered From Peritoneal Fluid of Women With Endometriosis at Different Stages. Reprod Sci. 2015. doi: 10.1177/1933719114536472
34. Laganà AS, Palmara V, Granese R, Ciancimino L, Chiofalo B, Triolo O. Desogestrel versus danazol as preoperative treatment for hysteroscopic surgery: a prospective, randomized evaluation. Gynecol Endocrinol. 2014; 30(11): 794-797. doi: 10.3109/09513590.2014.929658
35. Laganà AS, Burgio MA, Ciancimino L, et al. Evaluation of recovery and quality of sexual activity in women during postpartum in relation to the different mode of delivery: a retrospective analysis. Minerva Ginecol. 2014.
36. Laganà AS, Ciancimino L, Mancuso A, Chiofalo B, Rizzo P, Triolo O. onohysterography 3D versus hysteroscopy: Preliminary data from a cross-sectional study for the evaluation of intrauterine pathologies. Proceedings of the Sicilian Congress of the Italian Society of Gynaecological Endoscopy. Palermo, Italy. 2014.
37. Laganà AS, Ciancimino L, Mancuso A, Chiofalo B, Rizzo P, Triolo O. 3D sonohysterography vs hysteroscopy: a cross-sectional study for the evaluation of endouterine diseases. Arch Gynecol Obstet. 2014; 290(6): 1173-1178. doi: 10.1007/s00404-014-3366-6
38. Ciancimino L, Laganà AS, Chiofalo B, Granese R, Grasso R, Triolo O. Would it be too late? A retrospective case-control analysis to evaluate maternal-fetal outcomes in advanced maternal age. Arch Gynecol Obstet. 2014; 290(6): 1109-1114. doi: 10.1007/s00404-014-3367-5
39. Laganà AS, Condemi I, Salmeri FM, et al. Management dellendometriosi: sintesi delle linee guida dell. European Society of Human Reproduction and Embryology. Evidence. 2014; 6(5): e1000079.
40. Laganà AS, Gavagni V, Musubao JV, Pizzo A. The incidence of sexually transmitted diseases in patients migrants in Italy: ten years of experience in a clinic dedicated. Proceedings of the National Congress of the European Society for Infectious Diseases in Obstetrics and Gynaecology (ESIDOG) and of the Italian Society of Gynecology of Childhood and Adolescence (SIGIA). Florence. 2014.
41. Laganà AS, Gavagni V, Musubao JV, Pizzo A. The prevalence of sexually transmitted infections among migrant female patients in Italy. Int J Gynaecol Obstet. 2015; 128(2): 165-168. doi: 10.1016/j.ijgo.2014.08.013
42. Burgio MA, Sicilia A, Laganà AS. Sexual activity in the post-partum: unanalisi evidence-based. Maieutikos. 2014; 2: 47-49.
43. Giacobbe A, Grasso R, Imbesi G, et al. High mobility group protein B1: a new biomarker of obesity in pregnant women? Gynecol Endocrinol. 2014; 30: 1-3.
44. Burgio MA, Laganà AS, Sicilia A, et al. Preliminary data sulleffetto medium-term labor analgesia sullinsorgenza of female urinary incontinence in postpartum. Urogynaecologia International Journal. s2014; 28(2 Supp): 67-69.
45. Laganà AS, Barbaro L, Pizzo A. Evaluation of ovarian function and metabolic factors in women affected by polycystic ovary syndrome after treatment with D-Chiro-Inositol. Arch Gynecol Obstet. 2015. doi: 10.1007/s00404-014-3552-6.
46. Laganà AS, Pizzo A. Response to: Comment on Complete Androgen Insensitivity Syndrome: Optimizing Diagnosis and Management. Case Rep Obstet Gynecol. 2014; 2014: 808270. doi: 10.1155/2014/808270
47. Laganà AS, Condemi I, Sofo V, Salmeri FM, Triolo O. Induction of fetal lung maturity with corticosteroids: Which evidence to guide clinical practice. Acta Medica International. 2015; 2(1): 177-179.
48. Laganà AS, Pizzo A. Authors reply to: Empiric inositol supplementation in normal-weight non-insulin resistant women with polycystic ovarian disease: from the absence of benefit to the potential adverse effects. Arch Gynecol Obstet. 2015. doi: 10.1007/s00404-015-3663-8
49. Muscatello MR, Lorusso S, Bruno A, et al. Anger in women treated with assisted reproductive technology (ART): effects on mother and newborn. J Matern Fetal Neonatal Med. 2015; 10: 1-5.
50. Ciancimino L, Laganà AS, Imbesi G, Chiofalo B, Mancuso A, Triolo O. Evaluation of Maternal-Fetal Outcomes After Emergency Vaginal Cerclage Performed With Shirodkar-McDonald Combined Modified Technique. J Clin Med Res. 2015; 7(5): 319-3S23. doi: 10.14740/jocmr2108w
51. Laganà AS, Gavagni V, Musubao JV, Pizzo A. Evidence-based analysis dellincidenza delle malattie sessualmente trasmesse nelle pazienti migranti in Italia e futuri indirizzi di policy making. Proceedings of the National Congress of the Italian Group for Evidence-Based Medicine (GIMBE). Bologna. 2015.
52. Laganà AS, Burgio MA, Retto G, et al. Management of the second phase of labour: perineum protection techniques. Minerva Ginecol. 2015; 67(3): 289-296.
53. Laganà AS, Terzic M, Dotlic J, et al. The role of episiotomy in prevention of genital lacerations during vaginal deliveries – results from two european centers. Ginekol Pol. 2015; 86(3): 168-175.
Clinical Consultant Obstetrician & Gynaecologist
Resident Professor in Obstetrics & Gynaecology and in Midwifery
Academic Head of Department of Obstetrics & Gynaecology
Medical School, Mater Dei Hospital
Triq Dun Karm, L-Imsida, Malta
• Medical Doctorate (University of Malta, 1979)
• Accreditation Certificate in Obstetrics-Gynaecology (Leuven, Belgium, 1985)
• Fellow of the Royal College of Obstetricians & Gynaecologists (UK, 2000)
• Doctor of Medical Sciences (Warsaw, Poland, 1997)
• Fellow of the Royal College of Physicians of Ireland (Ireland, 2012)
• Accreditation Certificate in Obstetrics-Gynaecology (S.A.C, Malta, 2003)
• Consultant Obstetrician-Gynaecologist & Consultant i/c Diabetic Pregnancy Joint Clinic, Department of Health, Malta
• Professor and Head of Department of Obstetrics & Gynaecology, Faculty of Medicine & Surgery and Professor in Faculty of Health Sciences, University of Malta
• Specialist Obstetrician-Gynaecologist in Private Practice Served as Hospitaller & Historian, now serves as Grand Prior to the Grand Priory of the Maltese Islands of the Military and Hospitaller Order of Saint Lazarus of Jerusalem
His research interests include: Reproductive epidemiology and diabetes & medical disorders in pregnancy, Maltese history with emphasis on medical history, Natural Sciences particularly in field of geology, herpetology and mammology.
• Member of the Royal College of Obstetricians & Gynaecologists (UK, 1986)
• Member of the Royal College of Physicians of Ireland (Ireland, 2001)
1. Agius R, Savona-Ventura C, Vassallo J. Transgenerational metabolic determinants of fetal birth weight. Exp Clin Endocrinol Diabetes. 2013. doi: 10.1055/s-0033-1345121
2. Savona-Ventura C. Caring for Calypsos daughters - A History of Maternity Care in a Central Mediterranean Island. Malta University Press, Malta. 2013; 276.
3. Savona-Ventura C, Ross, M. The Heraldry and Development of the Order of Saint Lazarus of Jerusalem. Double Tessure: The Journal of the Heraldry Society of Scotland. 2013; 36: 2-28.
4. Savona-Ventura C, Savona-Ventura S. Endogenous physiological teratogenesis: The Maltese population - A Case study. LAP Lambert Academic Publishing, Germany. 2013.
5. Savona-Ventura C, Vassallo J, Marre M, Karamanos B, MGSD-GDM Study Group. A composite risk assessment model to screen for gestational diabetes in Mediterranean women. International Journal of Gynecology and Obstetrics. 2013; 120(3): 240-244. doi: 10.1016/j.ijgo.2012.10.016
6. Savona-Ventura C, Vassallo J, Marre M, et al. Fasting Plasma Glucose at 24-28 Weeks to Screen for Gestational Diabetes Mellitus. New Evidence from China. Diabetes Care. 2013, 36: 2038-2040. doi:
7. Savona-Ventura C, Vassallo J, Marre M, Karamanos B, MGSD-GDM Study Group. Obstetric adiposity in the Mediterranean region. International Journal of Gynecology and Obstetrics. 2013.
8. Formosa C, Savona-Ventura C, Mandy A. Cultural contributors to the development of diabetes mellitus in Malta. International Journal of Diabetes and Metabolism. 2012; 20: 25-29.
9. Gissler M, Fronteira I, Jahn A, et al. Terminations of pregnancy in the European Union. British Journal of Obstetrics and Gynaecology. 2012; 119: 324-332. doi: 10.1111/j.1471-0528.2011.03189.x
10. Gissler M, Fronteira I, Jahn A, et al. Terminations of pregnancy in Europe: the East-West divide. British Journal of Obstetrics and Gynaecology. 2012; 119: 1020-1021.
11. Karamanos B, Thanopoulou A, Anastasiou E, et al. Effect of the Mediterranean Diet and its components on the incidence of Gestational Diabetes in the Mediterranean region. International Symposium on Diabetes and Nutrition. Athens, Greece; 2012.
12. Sapiano K, Savona-Ventura C, Calleja-Agius J, Serracino-Inglott A, Azzopardi L. Attitudes towards pre-conception care in Maltese women with Type 1 Diabetes Mellitus. Gynecological Endocrinology. 2012. doi: 10.3109/09513590.2012.705370
13. Savona-Ventura C. An accoucher looks at the Torah. HUmanities and the Medical Sciences. 2012, 2012: 5-6.
14. Savona-Ventura C. Maltese links to Medieval Monastic and Military Orders. Journal of the Monastic Military Orders. 2012, 4: 35-46.
15. Savona-Ventura C. The Maltese vernacular in Medical education. In: Translational studies: An Anglo-Maltese scenario of reproductive health. LAP LAMBERT Academic Publ., Germany, 2012; 65-77. 16. Savona-Ventura C, Vassallo J, Marre M, Karamanos B, MGSD-GDM Study Group. Hyperglycaemia in pregnancy in Mediterranean women. Acta Diabetologica. 2012; 49: 473-480.
17. Abou-Hussein S, Abela M, Savona-Ventura C. Body Mass Index adjustment for sitting height for better assessment of obesity risks in Maltese women. International Journal of Risk and Safety in Medicine. 2012; 23: 241-248. doi: 10.3233/JRS-2011-0540
18. Abou-Hussein S, Savona-Ventura C, Grima S, Felice A. Genetic factors in risk assessment for the development of type 2 diabetes mellitus in a small case series. International Journal of Risk and Safety in Medicine. 2011; 23: 1-5.
19. Attard Montalto S, Savona-Ventura C. The William Hardy Shield for infant welfare rediscovered. Malta Medical Journal. 2011; 23(1): 40-45.
20. Fronteira I, Savona-Ventura C, Oliveira da Silva M. Country Profiles: The Reproductive Health Report - The state of sexual and reproductive health within the European Union. EU Final Report. Malta. 2011; 186-197.
21. Grech V, Savona-Ventura C, Gatt M, Attard-Montalto S. Factors influencing the future of paediatric private practice in Malta. Pediatric Reports. 2011; 3(2): 39-41.
22. Oliveira da Silva, M et al [incl. Savona-Ventura C - EU country collaborator]. The Reproductive Health Report - The state of sexual and reproductive health within the European Union. EU Final Report. 2011; 140.
23. Savona-Ventura C. Clinical Practice Guideline for the Management of diabetes during pregnancy. Department of Obstetrics and Gynaecology, UMMS, Malta. 2011; 24.
24. Savona-Ventura C. Clinical Practice Guideline for the Management of labour and delivery. Department of Obstetrics and Gynaecology. UMMS, Malta. 2011; 20.
25. Savona-Ventura C. Guidelines for Medical Students - Gynaecological & obstetric history taking and examination. Department of Obstetrics and Gynaecology. UMMS, Malta. 2011; 33.
26. Savona-Ventura C. Unreliability of online survey methods to assess population preferences in contraceptive practices. The European Journal of Contraception and Reproductive Health Care. 2011; 16: 147-148. doi: 10.3109/13625187.2010.550976
27. Savona-Ventura C. Universities Studies Melita - Medical Chirugiavque faculty ability of students. Faculty of Medicine & Surgery, Malta, 2011; 46.
28. Scerri C, Savona-Ventura C. Lifestyle risk factors for childhood obesity. Childhood Obesity. 2011; 7(1): 25-29.
29. Abou-Hussein S, Savona-Ventura C, Grima S, Felice AE. Allele scoring of genetic risk in previous GDM. 42nd Diabetes in Pregnancy Study Group Meeting. 2010; 35.
30. Grima S, Vella M, Savona-Ventura C. Hypertensive disorders during pregnancy in pre-Gestational diabetic women. Malta Medical Journal. 2010; 22(2): 15-18.
31. Sapiano K, Savona-Ventura C, Serracino-Inglott A, Azzopardi LM. Attitudes towards pre-conception care in Maltese women with Type 1 DM. 42nd Diabetes in Pregnancy Study Group Meeting. 2010; 41.
32. Savona-Ventura C. History of Gynaecology in Malta. Department of Obstetrics & Gynaecology, University of Malta. 2010; 47.
33. Savona-Ventura C. Maltese Medical Pauline traditions. Malta Medical Journal. 2010, 22(2): 34-36.
34. Savona-Ventura C. Professional medical journal publications in Malta. Malta Medical Journal. 2010; 22(3): 31-36.
35. Savona-Ventura C. The French Revolutions mark on the annals of the Order of St Lazarus of Jerusalem. Journal of the Monastic Military Orders. 2010; 3: 51-70.
36. Savona-Ventura C, Craus J, Vella K, Grima S. Lowest threshold values for the 75g oral glucose tolerance test in pregnancy. Malta Medical Journal. 2010; 22(1): 14-16.
37. Savona-Ventura C, Felice N, R.A. Gullaimier. The changing face of the Maltese population. Journal of population research. 2010; 27(4): 315-322.
38. Scerri C, Savona-Ventura C. Early metabolic imprinting as a determinant of childhood obesity. International journal of diabetes mellitus. 2010; 2: 175-178. doi: 10.1016/j.ijdm.2010.08.003
39. Zammit V, Zammit P, Savona-Ventura C, Buhagiar A, Grech V. Maltese National Birth Weight for Gestational Age Centile Values. Malta Medical Journal. 2010; 22(2): 19-24.
40. Mifsud M, Buttigieg GG, Savona-Ventura C, Delicata S. Reproductive health in Malta. The European Journal of Contraception and Reproductive Health Care. 2009; 14(4): 249-257. doi: 10.1080/13625180903072047
41. Savona-Ventura C. The History of Midwifery Education in the Maltese Islands. Department of Obstetrics & Gynaecology, University of Malta. 2009; 79.
42. Savona-Ventura C. Socio-biological determinants of reproductive health indicators. Social Transitions in Maltese Society. In: Cutajar J, Cassar G, eds. Agenda, Malta. 2009; 285-301.
43. Savona-Ventura C. Fenugreek - A natural prototype oral hypoglycaemic agent used in Malta. Malta Medical Journal. 2009; 21(2): 42-44.
44. Savona-Ventura C. Cervical Cancer Screening. Synapse. 2009; 4: 8-10.
45. Savona-Ventura C. World war II and population change in the Maltese context. Malta Medical Journal. 2009; 21(4): 41-45.
46. Savona-Ventura C. The Papal Bull Cum solerti meditatione pensamus. Journal of the Monastic Military Orders. 2009; 2: 21-38.
47. Savona-Ventura C, Buttigieg GG. Kings, knights and lepers. History of Medicine on-line, Priory Lodge Education Ltd. 2009.
48. Savona-Ventura C, Buttigieg GG, Felice N, Gulliamier RA, Gatt M. Risk factors for prematurity in the Maltese Islands: 1999-2006. International Journal of Risk and Safety in Medicine. 2009; 21(4): 177-184.
49. Savona-Ventura C, Buttigieg GG, Gatt M. Obstetric outcomes of immigrants of African Nationality. International Journal of Risk and Safety in Medicine. 2009; 21(3): 147-152.
50. Savona-Ventura C, Buttigieg GG, Mifsud M. Maternal weight gain and fetal growth. Malta Medical Journal. 2009; 21(2): 22-25.
51. Savona-Ventura C, Grima S, Buttigieg GG. Conjoint twinning in the Maltese Islands. Journal of Obstetrics and Gynaecology. 2009; 29(7): 599-604. doi: 10.1080/01443610903082500
52. Savona-Ventura C, Mogensen CE. History of Diabetes Mellitus. Elsevier Masson, Cedex. 2009; 86.
53. Buttigieg GG, Savona-Ventura C, Micallef Stafrace K. History of leprosy in Malta. Malta Medical Journal. 2008; 20(4): 34-38.
54. Buttigieg GG, Savona-Ventura C, Vella K, Cassar O. Cervical Carcinoma in the Maltese population. International Journal of Risk and Safety in Medicine. 2008; 20(4): 223-230.
55. Inguanez J, Savona-Ventura C. Not a Euthanasia. DISCERN: Institute for Research on the Signs of the Times, Malta. 2008; 128.
56. Savona-Ventura C. Malta (Republic of). Pocket Guide to Cultural Health Assessment. 4th ed. In: Erickson dAvanzo C, eds. Mosby, USA. 2008; 465-469.
57. Savona-Ventura C. The Order of St Lazarus in the Kingdom of Jerusalem. Journal of the Monastic Military Orders. 2008; 1: 55-64.
58. Savona-Ventura C. Knight Templar remains in Gozo? The Gozo Observer. 2008; 19: 6-11.
59. Savona-Ventura C. The hospitaller activities of the Sisters of Charity of St Joan Antide in the Maltese Islands. Storja. 2008; 80-91.
60. Savona-Ventura C, Buttigieg GG. Prematurity in the Maltese Islands. Report prepared for the European Parturition Group. Department of Obstetrics-Gynaecology, Malta. 2008; 12.
61. Savona-Ventura C, Buttigieg GG, Grima S. Metabolic Carcinogenesis in the Maltese population. Experimental and Clinical Endocrinology & Diabetes. 2008; 116: 1-5.
62. Savona-Ventura C, Buttigieg GG, Grima S. Outcomes of hypertensive obstetric patients in the Maltese Islands. International Journal of Gynaecology and Obstetrics. 2008; 101(2): 189-191.
63. Savona-Ventura C, Buttigieg GG, Grima S, Vella M. Anthropomorphic characteristics as obstetric risk determinants. International Journal of Risk and Safety in Medicine. 2008; 20(3): 155-160.
64. Savona-Ventura C, Chircop M. Significant thresholds for the 75g oral glucose tolerance test in pregnancy. Journal of Diabetes and its Complications. 2008; 22(3): 178-180. doi: 10.1016/j.jdiacomp.2006.10.001
65. Savona-Ventura C, Gatt M, Vella K, Grima S. Higher Order Multiple Pregnancy Outcomes in the Maltese Islands: 2000-2004. Malta Medical Journal. 2008; 20(1): 19-23.
66. Savona-Ventura C, Grima S. Hypertensive disorders during pregnancy in Gestational Diabetic women. Experimental and Clinical Endocrinology & Diabetes. 2008; 116: 1-4.
67. Savona-Ventura C, Grima S, Vella K. Maternal BMI and antenatal weight gain as determinants of obstetric outcome. International Journal of Diabetes & Metabolism. 2008; 16: 5-53.
Department of Obstetrics & Gynaecology
School of Medicine
University of Western Sydney
Building 30.2.26, Campbelltown Campus
Locked Bag 1797, Penrith NSW 2751, Australia
Andrew Korda is currently Professor of Obstetrics and Gynaecology at the University of Western Sydney, Lecturer in Gynaecology at the University of Sydney, Chairman of the Pelvic Floor Unit at the Royal Prince Alfred Hospital, Senior Gynaecological Surgeon at the Royal Prince Alfred Hospital, Chairman of the Medical Advisory Board at the Sydney Day Surgery, and Trustee of the Australian Bladder Foundation.
He is a past Chairman of the Urogynaecological Subspecialty Committee of the Royal Australian and New Zealand College of Obstetricians and Gynaecologists, Associate Editor of the International Urogynaecological Journal, Chief Examiner in Urogynaecology of the Royal Australian and New Zealand College of Obstetricians and Gynaecologists, Examiner for the Membership in the Royal Australian and New Zealand College of Obstetricians and Gynaecologists, Head of the Department of Gynaecology at Royal Prince Alfred Hospital. He has been involved in numerous RANZCOG educational activities over the years.
Andrew Korda is a graduate in Medicine from the University of Sydney (MB BS). He is a Fellow of the RANZCOG (FRANZCOG) with Certification in Urogynaecology (CU) and is a Fellow of the Australian College of Legal Medicine (FACLM). He holds Masters’ degrees in Arts and Health Law from the University of Sydney.
Andrew Korda is currently involved in four significant professional activities: membership of the faculty of medicine and teaching of medical students at the newly established University of Western Sydney Medical School; running a private general gynaecological and urogynaecological practice at the Royal Prince Alfred Medical Centre; running urodynamic diagnostic services in five major centres in Sydney: Newtown, St Leonards, Chatswood, Bankstown, Concord, Liverpool and Penrith; and providing public gynaecological and urogynaecological care at the Royal Prince Alfred Hospital, including being on call for gynaecological and obstetric disasters.
Andrew Korda was awarded the Mabel Elizabeth Leaver Prize for Obstetrics and the Aisling Memorial Society Prize by the University of Sydney; was Chenhall Travelling Fellow in Gynaecology and recipient of the Searle Travelling Fellowship.
He has held research and consultant positions in Sydney, Oxford (UK), Banbury (UK) and New York (USA). He has published extensively in the medical literature on pelvic floor and urinary dysfunction in women, is the author of eighty-five original articles in refereed journals and chapters in books.
He is a member of the International Urogynaecological Association, International Continence Society, the Urodynamics Society, the Australian Medical Association and the Medico legal Society of New South Wales.
Andrew Korda has had many years experience in medico-legal work, providing independent medico-legal opinions to plaintiff and defence lawyers and is accredited to give medico-legal opinion in general gynaecology and urogynaecology by the Royal Australian and New Zealand College of Obstetricians and Gynaecologists.
His research interests include: Medico legal issues, Nazi Medical Experimentation, Pelvic Floor Disorders, Urogynaecology.
MEMBERSHIP OF COMMITTEES AND LEARNED SOCIETIES
• 1972 Member of the Medico-Legal Society of NSW
• 1975-1980 Secretary, Medical Board, Royal Prince Alfred Hospital, Sydney
• 1977-1979 Member and Honorary Treasurer NSW Committee, Royal College of Obstetricians and Gynaecologists
• 1979-1984 Member and Honorary Treasurer NSW State Committee, Royal Australian College of Obstetricians and Gynaecologists
• 1983-1984 Treasurer, 2nd Congress of the Australian College of Obstetricians and Gynaecologists, Singapore
• 1983-1984 Visiting Medical Officers’ Association, Royal Prince Alfred Hospital, Sydney
• 1983-1984 Member, International Urogynaecological Association
• 1983-1984 Member, International Continence Society
• 1985 - Director, Sydney Day Surgery Prince Alfred
• 1987 Examiner, Part 1, Royal Australian College of Obstetricians and Gynaecologist
• 1988-1994 Associate Editor of The International Urogynaecological Journal
• 1989 Associate Member, Urodynamics Society
• 1989 Treasurer, Jubilee Congress, King George V Hospital, Royal Prince Alfred Hospital, Sydney
• 1990 Treasurer, Organising Committee, “Opus Meum” International Symposium in Honour of Professor R.P. Shearman
• 1991-2000 Examiner, Part II, Royal Australian College of Obstetricians and Gynaecologists • 1993 Treasurer, International Continence Society Meeting, Sydney, 1995
• 1994-1998 Fellow of The Royal Society of Medicine 4
• 1995-2002 Member, Urogynaecological Subspecialty Committee, Royal Australian College of Obstetricians & Gynaecologists
• 1999-2000 Associate Member, The Australian College of Legal Medicine
• 1999-2002 Chairman, Urogynaecological Subspecialty Committee, Royal Australian and New Zealand College of Obstetricians & Gynaecologists
• 2003-2004 Chairman, Morbidity and Mortality Meetings in Gynaecology Royal Prince Alfred Hospital
• 2005 Accredited to give medico-legal opinion in general gynaecology and urogynaecology by the Royal Australian and New Zealand College of Obstetricians and Gynaecologists
• 2009 Chairman, Medical Advisory Board, Sydney Day Surgery, Prince Alfred (CURA)
1. Korda A, Shearman RP. Induction of Ovulation with Clomiphene Citrate. International Journal of Gynaecology and Obstetrics. 1972; 10(2).
2. Korda A, Shearman RP, Smith ID. Termination of Pregnancy by Intra-Uterine Prostaglandin F2A. Australian and New Zealand Journal of Obstetrics and Gynaecology. 1972; 12: 166.
3. Korda A. Some Observations on the Use of Prostaglandin F2A for Termination of Pregnancy. Proceedings of the Australian and New Zealand Obstetrical and Gynaecological Research Society. Melbourne. 1972.
4. Korda A, Shearman RP, Smith ID. Lactation Induced in Women Undergoing Abortion with Prostaglandin F2A. Nature. 240:411.
5. Korda A, Shearman RP, Smith ID. Abortofacient Action of Prostaglandins with Particular Reference to the Use of PGF2A Administered into the Amniotic Sac in Second Trimester of Pregnancy. Clinical Proceedings of International Planned Parenthood Federation, South East Asia and Oceania, Regional Medical and Scientific Congress. Sydney, Australia. 1972.
6. Korda A. Intra-Uterine Administration of Prostaglandin F2A During the Second Trimester of Pregnancy; Clinical and Hormonal Results. Proceedings of the Australian Society for Reproductive Biology, 4th Annual Meeting. August, 1972.
7. Korda A, Shearman RP, Smith ID. Chronoperiodicity in the Response to Intra-Amniotic Injection of PGF in the Human. Nature. 1972; 241: 279. doi: 10.1038/241279a0
8. Korda A, Shearman RP, Smith ID. The Prostaglandins. Clinical Application in Human Reproduction. Future Publishing Company, Inc. Mount Kisco, New York. 1973. 9. Korda A, Lyneham RC, Shearman RP, Smith ID, McLeod J. Convulsions and Abnormalities in Electroencephalogram Following Intra- Amniotic Prostaglandin PGF2. Lancet. 1973; 11: 1003- 1005.
10. Korda A, Lyneham RC, Jones WR. The Treatment of Premature Labour with Intravenous Salbutamol. Medical Journal of Australia. 1974; 1(19): 744.
11. Korda A, Lyneham RC, Shearman RP. Intra-Amniotic PGF2 Administration for Termination of Second Trimester Pregnancies. The Journal of the Asian Federation of Obstetrics and Gynaecology. 1973.
12. Korda A, Lyneham R. The Treatment of Iron Deficiency Anaemia with Intravenous Iron-Dextran. The Journal of the Asian Federation of Obstetrics and Gynaecology. 1973.
13. Korda A, Frumar AM, Smith ID, Shearman RP. Prostaglandin F2A for the Induction of Labour in Pregnancies Complicated by Intrauterine Death, Anencephaly and Chromosomal Anomaly. Postaglandins. 1974.
14. Korda A, Shearman RP, Smith ID. Side- Effects Following Intra- Amniotic Injection of PGF2A. Australian and New Zealand Journal of Obstetrics and Gynaecology. 1974; 14: 117.
15. Korda A, Lyneham RC, Shutt ID, Shearman RP, Smith ID. Effects of Intrauterine Prostaglandin F2A on Corpus Luteum Function. Prostaglandins. 1975; 9: 431.
16. Korda A, Lyneham RC, Shutt ID, Shearman RP, Smith ID. Assessment of possible luteolytic effect of intra- ovarian injection of prostaglandin f2a in the human. Prostaglandins. 1975; 9: 443.
17. Korda A, Challis J, Anderson ABM, Turnbull AC. Assessment of placental function in normal and pathological pregnancies by estimation of plasma oestradiol levels after injection of dehydroepiandrosterone sulphate. The British Journal of Obstetrics and Gynaecology. 1975; 82(8): 656- 661. doi: 10.1111/j.1471-0528.1975.tb00702.x
18. Korda A, Challis J, Anderson ABM, Turnbull AC. Plasma Unconjugated 15 Hydroxy Oestriol (Oestetrol) Levels in Normal Human Pregnancy. British Journal of Obstetrics and Gynaecology. 1975; 82. doi: 10.1111/j.1471-0528.1975.tb00592.x
19. Korda A. The Prevention of Prematurity. Medical Journal of Australia. 1977; 2: 671- 673.
20. Korda A, Tiller DJ, Horvath J. Pre- Eclampsia and Eclampsia. Medical Journal of Australia. 1978; 1: 32- 33.
21. Korda A, Horvath J. Renal Physiology, chapter in Human Reproductive Physiology. In: Shearman RP. Blackwell Scientific Publications; Second edition. 1979.
22. Korda A, Elliott PM. Tubal Anastomoses by Means of Modified Microsurgical Technique. Medical Journal of Australia. 1980; 1: 596- 598.
23. Korda A, Tiller DJ, Horvath J, Fleming S, Duggin G. The Effects of Hydrostatic Pressure in the Measurement of Blood Pressure in Pregnancy. Second International Congress of Hypertension in Pregnancy. 1981.
24. Korda A. Management of Hypertension in Pregnancy. Research in Progress. National Heart Foundation of Australia. 1980.
25. Korda A, Tiller DJ, Duggin G, Henderson- Smart D, Phippard A. High Risk Hypertensive Pregnancies: Maternal and Foetal Outcome in 277 Cases. Clinical and Experimental Hypertension. 1982; B(2, 3): 208.
26. Korda A, Phippard A, Horvath J, Tiller DJ, Henderson- Smart D. Treatment of Hypertension in Pregnancy with Clonidine. Clinical and Experimental Hypertension. 1982; B(2, 3): 208.
27. See T, Korda A, Horvath J. Errors in Measurement of Blood Pressure. The Australian and New Zealand Journal of Obstetrics and Gynaecology. 1983; 23(3): 136.
28. Korda A. Acute Severe Hypertension. Proceedings of the Second Congress, Royal Australian College of Obstetricians and Gynaecologists. August, 1983.
29. Korda A, Phippard A, Horvath J, Tiller DJ, Henderson- Smart D, Duggin G. ‘High Risk’ Hypertensive Pregnancies-Maternal and Foetal Outcome. Clinical and Experimental Hypertension, Hypertension in Pregnancy. 1983; B2(1): 21- 28.
30. Korda A, Horvath J, Henderson- Smart D, et al. The Effect of Antihypertensive Drugs on Neonatal Blood Pressure. Clinical Experiment Physiology and Pharmacology. 1984. doi: 10.1111/j.1440-1681.1984.tb00277.x
31. Korda A. Urinary Incontinence-Desperate Measures. Proceedings of the Third Advanced Course of the Royal Australian College of Obstetricians and Gynaecologists. 1984.
32. Korda A, Horvath J. Acute Severe Hypertension. ANZ Journal of Obstetrics and Gynaecology. 1984; 24: 72.
33. Korda A, Fleming S, Shutt D, Senior C, Shearman RP. The Effects of Intra- Amniotic T3 on Foetal Lung Maturity in Lambs at 132 Days Gestation. Paediatric Research. 1984; 18: 932.
34. Korda A. How to Create Continence without Surgery. 3rd ANZ Congress of Obstetricians and Gynaecologists Adelaide. 1985. 35. Korda A, Horvath JS, Child AG, et al. Clonidine Hydrochloride, A Safe and Effective Anti-hypertensive Agent in Pregnancy. Comparing Clonidine Hydrochloride and Alpha Methyl Dopa. Obstetrics and Gynaecology. 1985; 66(5): 634-638.
36. Korda A. The Evaluation of the Incontinent Female. Modern Medicine. 1985; 28(6): 51- 54.
37. Korda A, Horvath JS, Child AG, et al. Hypertension in Pregnancy. A Study of 142 Women Presenting Before 32 Weeks Gestation. Medical Journal of Australia. 1985; 143: 19- 21.
38. Korda A, Horvath JS, Child AG, et al. Clonidine Hydrochloride- A Safe and Effective Antihypertensive Agent in Pregnancy. Obstetrics and Gynaecology. 1985; 8: 39-40.
39. Korda A. The Incontinent Female-Modern Evaluation Methods. Australian Family Physician. 1986; 15(11): 1409- 1411.
40. Korda A, Krieger M, Hunter P. The Value of Clinical Symptoms and Physical Signs in the Diagnosis of Urinary Incontinence in the Female. ANZ Journal of Obstetrics and Gynaecology. 1987; 27: 149.
41. Korda A, Krieger M, Hunter P. Cystodistension in the Treatment of Detrusor Instability. ANZ Journal of Obstetrics and Gynaecology. 1987; 27: 149.
42. Korda A, Krieger M, Hunter P. The Value of Clinical Symptoms and Physical Signs in the Diagnosis of Urinary Incontinence in the Female. Obstetrics and Gynaecology ‘Survey’. 1988.
43. Korda A, Peat B, Hunter P. Experience with Silastic Slings for Female Urinary Incontinence. International Urogynaecological Journal. 1988; 1(1): 327. doi: 10.1111/j.1479-828X.1989.tb01706.x
44. Korda A, Krieger M, Hunter P. The value of clinical symptoms and physical signs in the diagnosis of urinary incontinence in the female. Year book of Obstetrics and Gynaecology. 1988.
45. Korda A. Experience with Silastic Slings in the Cure of Urinary Incontinence in the Female. ANZ Journal of Obstetrics and Gynaecology. 1989; 29: 150.
46. Korda A, Ferry J, Hunter P. Colposuspension for the Treatment of Female Urinary Incontinence. ANZ Journal of Obstetrics and Gynaecology. 1989; 29: 146.
47. Korda A, Krieger M, Hunter P. Cystodistension in the Treatment of Detrusor Instability. Year Book of Obstetrics and Gynaecology. 1989.
48. Korda A. Silastic Slings for Female Incontinence. International Urogynaecology Journal. 1989; 1(2): 5- 7. doi: 10.1007/BF00600021
49. Korda A. Coital Urinary Incontinence in an Australian Population. Asia-Oceania Journal of Obstetrics and Gynaecology. 1989; 15(4). doi: 10.1111/j.1447-0756.1989.tb00194.x
50. Korda A, Phippard A, Fischer W, et al. Early Blood Pressure Control Improves Pregnancy Outcome in Primigravidae with Mild Hypertension. Medical Journal of Australia. 1991; 154(6): 378.
51. Korda A. Elevation of the Vagina During Colposuspension: The Use of Deaver Retractor. Br J of Urol. 1990; 66: 668.
52. Korda A. Blood Pressure Control in Primigravid Women with Mild Hypertension. The Medical Journal of Australia. 1991; 154: 706.
53. Korda A. Urology for the Gynaecologist, The Unstable Bladder. Audio-digest, Obstetrics and Gynaecology. 1991; 38(19).
54. Korda A, Phippard A, Fischer W, et al. Early Intervention in Primigravid Women Developing Mild Hypertension. ACP Journal Club, Supp. Annais of Internal Medicine. 1991; 115 (supp. 3): 79- 80.
55. Korda A, Phippard A, Fischer W, et al. Early Intervention in Primigravid Women Developing Mild Hypertension. Key Obstetrics and Gynaecology. 1992.
56. Korda A, Brieger G. The Effect of Obesity on the Outcome of Successful Surgery for Genuine Stress Incontinence. ANZ Journal of Obstetrics and Gynaecology. 1992; 32: 71- 72. doi: 10.1111/j.1479-828X.1992.tb01905.x
57. Korda A, Peat B, Boogert A, Anderson J, Thornton J. Transvaginal Ultrasound for the Detection of Urethral Diverticula at Urodynamic Assessment. International Urogynaecology Journal. 1992; 3(2): 118- 120. doi: 10.1007/BF00455085
58. Korda A, Brieger G. The Surgical Treatment of Recurrent Genuine Stress Incontinence. International Urogynaecology Journal. 1993; 4(1): 31- 33.
59. Korda A, Phippard A, Fischer W, et al. Early Intervention in Primigravid Women Developing Mild Hypertension. Year Book in Obstetrics and Gynaecology. 1993.
60. Korda A. The Effect of Obesity on the Outcome of Successful Surgery for Genuine Stress Incontinence. Current Opinion in Obstetrics and Gynaecology, E.E. Wallach (ed.), Current Science Ltd. London, August, 1993.
61. Korda A, Brieger G, Ditton J. Insertion of a Permanent Electrode for Intractable Detrusor Instability. The Australian Journal of Obstetrics and Gynaecology. 1995; 35(1): 107. doi: 10.1111/j.1479-828X.1995.tb01847.x
62. Korda A. Medicine Betrayed. The participation of doctors in human rights abuses in Nazi Germany. Research Thesis for a Master of Arts. Dept. of History, The University of Sydney. Held in Rare Book Library of the University of Sydney. 1995.
63. Korda A, Brieger G, Houghton R. Abdomino-Perineal Repair of Pulsion Enterocoele. The Journal of Obstetrics and Gynaecology Research. 1996; 22(2).
64. Korda A, Manning J, Benness C. Urethroscopy-Its Role in Urodynamic Assessment. International Urogynaecology Journal and Pelvic Floor Dysfunction. 1996; 7(2): 14.
65. Korda A, Kesby G. Migration of a Filshie clip into the urinary bladder following laparoscopic ligation of the fallopian tubes. British Journal of Obstetrics and Gynaecology. 1997; 104: 379- 382. doi: 10.1111/j.1471-0528.1997.tb11473.x
66. Korda A, Manning J, Benness C. The role of prophylactic antibiotics following urodynamics. International Urogynaecology Journal and Pelvic Floor Dysfunction. 1998; 5(9): 66.
67. Korda A, Manning J, Benness C, Houghton R, Solomon M. Obstructed defaecation and uterovaginal prolapse. International Urogynaecology Journal and Pelvic Floor Dysfunction. 1998; 9(5): 67.
68. Korda A, Manning J, Benness C, Solomon M. Anorectal symptoms in women with lower urinary tract dysfunction. International Urogynaecology Journal and Pelvic Floor Dysfunction. 1998; 9(5): 68.
69. Korda A, Manning J, Benness C. The role of skin elasticity in uterovaginal prolapse and GSI. International Urogynaecology Journal and Pelvic Floor Dysfunction. 1998; 9(5): 69.
70. Korda A, Manning J, Benness C. Does Uterovaginal Prolapse Cause Voiding Dysfunction? Neurourology and Urodynamics. 1999; 18(4): 68.
71. Korda A, MacGibbon A, Brieger G. Incisionless cystourethropexy - the Intac device - an initial experience. Australian and New Zealand Journal of Obstetrics and Gynaecology. 2000; 40(1): 59-61. doi: 10.1111/j.1479-828X.2000.tb03168.x
72. Korda A. The Management of Pulsion Enterocoele with the Zacharin Abdomino-perineal technique. Gastroenterology International. 2000; 13(2): 79.
73. Korda A. How to check for vaginal prolapsed. Medicine Today. 2000; 97-99.
74. Korda A. The Management of Pulsion Enterocoele with the Zacharin Abdomino-perineal technique. The Australian and New Zealand Journal of Obstetrics and Gynaecology. 2000; 40(3): 303-307.
75. Korda A. Early Australian Experience of the TVT procedure. International Urogynaecology Journal. 2000; 11(Suppl 1): IDP6 S67.
76. Korda A. The association of obstructive defecation, lower urinary tract dysfunction and the benign joint hypermobility syndrome: A case-control study. International Urogynaecology Journal. International Urogynaecology Journal. 2003; 14: 128-132. doi: 10.1007/s00192-002-1025-0
77. Korda A. Is there an association between faecal incontinence and lower urinary dysfunction? Diseases of the Colon and Rectum.
78. Korda A, Dietz HP, Pang S, Benness C. Paravaginal defects: a comparison of clinical examination and 2D/3D ultrasound imaging. Australian and New Zealand Journal of Obstetrics and Gynaecology. 2005; 45: 187-190. doi: 10.1111/j.1479-828X.2005.00377.x
79. Dietz HP, Korda A. Which bowel symptoms are most strongly associated with a true rectocele? Aust N Z J Obstet Gynaecol. 2005; 45(6): 505-508. doi: 10.1111/j.1479-828X.2005.00486.x
80. Korda A. The Nazi Medical Experiments ADF Health. Journal of the Australian Defence Health Service. 2006; 7: 133-137.
81. Korda A.TVT vs TVT-O: A study comparing early complications. In Urogynecol J. 2007; 18 Suppl S25: S105 062 S37
82. Korda A. How to treat Incontinence. The Australian Doctor. 2010.
83. Korda A, Koh C, Deans R, Korda A, Young C Solomon M. Functional Outcome Following Combined Zacharin’s Pelvic floor Repair and Rectopexy for Pelvic Prolapse. Tripartite Annual Scientific Meeting Proceedings. Colorectal Surgery. 2011.
84. Koh C, Deans R, Korda A, Young C, Solomon M. Functional Outcome Following Combined Zacharin’s Pelvic floor Repair and Rectopexy for Pelvic Prolapse. Aust NZ Surg. 2011: 81 (Suppl. 1): A23-A24.
85. Dietz HP, Shek KL, Korda A. Can the levator hiatus be reduced surgically? ISUOG. 2011.
86. Dietz HP, Shek KL, Korda A. Can levator avulsion be corrected surgically? Neurology and Urodynamics. 2011; 30(6): 877-879.
87. Tooher J, Thornton C, Ogle R, et al. Increased Maternal Mortality after Hypertension in Pregnancy. International Study of Hypertension in Pregnancy, Geneva. 2012.
88. Dietz HP, Shek KL, Korda A. Can levator avulsion be repaired surgically ? Int Urogynecol J. 2012.
89. Krishnan S, Li Y, De Vries B, Benness C, Daly O, Korda A. Bladder and bowel function following treatment of deeply infiltrating endometriosis: a role for a nerve sparing approach. Int Urogynecol. 2012: (Suppl 2): s43-S244 62.
90. Dietz HP, Korda A, Benness C, Wong V, Shek KL, Daly O. Surgical reduction of the levator hiatus. Neurology and Urodynamics. 2012; 31(6): 862-864.
91. Tooher J, Thornton C, Makris A, et al. Individual Patient Assessment for Long term Cardiovascular Outcomes following Hypertension During Pregnnacy. Hypertension .
92. Thornton CE Dahlen H Korda A Hennessy A. The incidence of preeclampsia and eclampsia and associated maternal mortality in Austyralia from population linked datasets: 2000-2008. American J Obs Gynecol.
93. George A, Johnson M, Reath J, et al. Oral Health Care During Pregnancy. Australian Nursing Journal (special issue women’s health/midwifery). 2013; 21(3): 42.
94. Korda A. Where to with treatment of pelvic organ prolapse in 2014. MedicineToday. 2014; 15(5): 63-67.
95. Korda A. Women’s Health for the Physician Chapter in Essentials of Internal Medicine edited by Nicholas Talley, Brad Frankum and David Currow 3rd edition Churchill Livingstone Elsevier, Sydney, Edinburgh, London, New York, Philadelphia, St Louis, Toronto 2015.
Maternal & Fetal Health Research Group
Centre for Womens Health
Institute of Human Development
Faculty of Medical and Human Sciences
University of Manchester
St. Marys Hospital, Oxford Road
Manchester M13 9WL, UK
Dr. Brownbill studied Applied Biological Sciences at Manchester Metropolitan University. With a keen interest in physiology, he first pursued a career into secretory epithelia and the expression of transporter proteins. and he transferred to the Maternal & Fetal Health Research Group, University of Manchester, studying the transplacental transfer of solute and water, characterised the transplacental paracellular route across the syncytiotrophoblastand then investigated the regulation of fetoplacental vascular tone. He received his MPhil and PhD for his work in this field and continue to work within this high profile research centre as a Research Fellow, where he study human placental physiology and toxicology.
He have undertaken EU networking and industrial collaborations to establish the ex vivo dual human placental perfusion system and other placental models to study the toxic effects of medicines and their transplacental transfer. He expects this to influence UK and EU regulatory policies on testing of drugs for use in pregnancy in the near future.
Further interests include investigating the aetiology of compromised fetoplacental blood flow in relation to the fetoplacental endotheliumin fetal growth restriction, this condition also associates with his work on the mechanisms of placental pathology in stillbirth pregnancies.
His research interest include: Maternal and Fetal blood flow and Flow matching, and have catalysed the establishment of an international network of placental physiologists, Pathologists, Clinicians, biophysicists and Mathematical modellers interested in understanding this in relation to normal placental sufficiency and in pathological pregnancies. Other interests are centred on Cell free haemoglobin in the placenta with respect to dysregulation of fetoplacental vascular physiology as well as inflammatory effects within the placenta and in Adult haemolytic diseases.
MEMBERSHIP OF SCIENTIFIC SOCIETIES
• Physiological Society
• British Microcirculation Society
• European Society for Microcirculation
• International Federation of Placental Associations
• Fetal and Neonatal Physiological Society
• European Placenta Group
• Blair Bell Society
FULL PEER REVIEWED PAPERS
1. Brownbill P, Edwards D, Jones CP, et al. Mechanisms of alphafetoprotein transfer in the perfused human placenta cotyledon from uncomplicated pregnancy. J Clin Invest. 1995; 96: 2220-2226. doi: 10.1172/JCI118277
2. Sibley CP, Birdsey TJ, Brownbill P, et al. Mechanisms of maternofetal exchange across the human placenta. Biochem Soc Trans. 1998; 26: 86-91.
3. Ratts VS, Tao XJ, Webster CB, et al. Regulation of apoptotic cell death within the trophoblastic layer: role of BCL-2, BAX and BAK in the term human placenta. J Soc Gynecol Invest. 1998; 5: T358.
4. Brownbill P, Mahendran D, Owen D, et al. Denudations as paracellular routes for alphafetoprotein and creatinine across the human syncytiotrophoblast. Am J Physiol. 2000; 278: R677-R683.
5. Ratts VS, Tao XJ, Webster CB, et al. Expression of BCL-2, BAX and BAK in the trophoblast layer of the term human placenta: A unique model of apoptosis within a syncytiotrophoblast. Placenta. 2000; 21: 361-366. doi: http://dx.doi.org/10.1053/plac.1999.0486
6. Brownbill P, Bell NJ, Woods RJ, Lowry PJ, Page NM, Sibley CP. Neurokinin B is a paracrine vasodilator in the human fetal placental circulation. J Clin Endocrinol Metab. 2003; 88: 2164-2170. doi: http://dx.doi.org/10.1210/jc.2002-021727
7. Leach L, Badet J, Brownbill P, et al. Endothelium, blood vessels and angiogenesis-a workshop report. Placenta. 2006; 27: 26-29. doi: 10.1016/j.placenta.2006.01.022
8. Brownbill P, Sibley CP. Regulation of transplacental water transfer: the role of fetoplacental venous tone. Placenta. 2006; 27: 560-567. doi: http://dx.doi.org/10.1016/j.placenta.2005.08.002
9. Cleal JK, Brownbill P, Godfrey KM, et al. Modification of fetal plasma amino acid composition by placental amino acid exchangers in vitro. J Physiol. 2007; 582(2): 871-882.
10. Brownbill P, McKeeman GC, Brockelsby JC, Crocker IP, Sibley CP. Vasoactive and permeability effects of vascular endothelial growth factor-165 in the term in vitro dually perfused human placental lobule. Endocrinology. 2007; 148: 4734-4744. doi: http://dx.doi.org/10.1210/en.2007-0180
11. Brownbill P, Mills TA, Soydemir DF, Sibley CP. Vasoactivity to and endogenous release of vascular endothelial growth factor in the in vitro perfused human placental lobule from pregnancies complicated by preeclampsia. Placenta. 2008; 29: 950-955. doi: 10.1016/j.placenta.2008.08.020
12. Jones NW, Hutchinson ES, Brownbill P, et al. In vitro dual perfusion of human placental lobules as a flow phantom to investigate the relationship between fetoplacental flow and quantitative 3D power doppler angiography. Placenta. 2009; 30(2): 130-135.
13. Hutchinson ES, Brownbill P, Jones NW, et al. Utero-placental haemodynamics in the pathogenesis of pre-eclampsia. Placenta. 2009; 30: 634-641. doi: 10.1016/j.placenta.2009.04.011
14. Sibley CP, Brownbill P, Dilworth MR, Glazier JD. Adaptation in Placental Nutrient Supply to Meet Fetal Growth Demand: Implications for Programming. Placenta 31(A) Trophoblast Research. 2010; 24: S70-S74. doi: 10.1016/j.placenta.2009.12.020
15. Soydemir F, Kuruvilla S, Brown M, et al. Adapting in vitro dual perfusion of the human placenta to soluble oxygen tensions associated with normal and pre-eclamptic pregnancy. Lab Invest. 2011; 91(2): 181-189. doi: 10.1038/labinvest.2010.171
16. Abumaree MH, Brownbill P, Burton G, et al. IFPA Meeting 2013 Workshop Report III: Maternal placental immunological interactions, novel determinants of trophoblast cell fate, dual ex vivo perfusion of the human placenta. Placenta. 2014; 35: S15-S19. doi: 10.1016/j.placenta.2013.11.009
17. Jain A, Schneider H, Aliyev E, et al. Hypoxic treatment of human dual placental perfusion induces a preeclampsia-like inflammatory response. Lab Invest. 2014; 94: 873-880. doi: 10.1038/labinvest.2014.76.
18. Junaid TO, Brownbill P, Chalmers N, Johnstone ED, Aplin JD. Fetoplacental vascular alterations associated with fetal growth restriction. Placenta. 2014; 35: 808-815. doi: 10.1016/j.placenta.2014.07.013
19. Serov AS, Salafia CM, Brownbill P, Grebenkov DS, Filoche M. Optimal villi density for maximal oxygen uptake in the human placenta. J Theor Biol. 2015; 364: 383-396. doi: 10.1016/j.placenta.2014.07.013
20. Brownbill P. Human placentas and the changing face of reproductive toxicology testing. Gynecol Obstet Res Open J. 2015; 2(3): e9-e10. doi: 10.17140/GOROJ-2-e004
Consultant Gynaecologist / Director of Fertility Control Unit
Department of Obstetrics and Gynaecology
St. Jamess University Hospital Leeds
Beckett Street, Leeds, West Yorkshire LS9 7TF, UK
Dr. Gbolade is Consultant Gynaecologist / Director of Fertility Control Unit, Department of Obstetrics and Gynaecology at St. Jamess University Hospital Leeds, England. He is also a Senior Clinical Lecturer, Academic Medical Educators Unit, Leeds Institute of Medical Education at University of Leeds.
He was previously Clinical Lecturer in Family Planning & Reproductive Health Care, Academic Department of Obstetrics & Gynaecology and Reproductive Healthcare at The University of Manchester, England, where he undertook research into emergency contraception, Depo-Provera and bone density. At Leeds, he has worked closely with leading researchers at the University of Leeds, investigating decision-making about pregnancy termination methods.
Dr Gbolade has a passion for academic peer review and editorial work, currently serving on the editorial boards of many international journals and as a peer reviewer for others.
He has an avid interest in applying the benefits of medical information technology to the provision of healthcare, and holds an MSc in Computational Methods in Medical Science from The University of Manchester, England.
He also has a strong interest in medical law and research ethics, holds an MPhil in Medical Law, and served as an Expert Member of the Northern and Yorkshire NHS Research Ethics Committee for 10 years.
Throughout his career in healthcare services and academia, he has focused on female reproductive healthcare with special emphasis on access, quality, equity, and appropriate use of modern technology.
His research interests include: Contraception, Reproductive Healthcare, Fertility Control, Gynaecology.
Memberships in Professional Societies
• Association of Broadcasting Doctors
• British Medical Association
• European Society of Contraception
• International Academy of Pelvic Surgery
• Manchester & District Medico-Legal Society
• Northern Interbranch Doctors group (NIBG)
• North of England Obstetrical & Gynaecological Society
• Publication Integrity & Ethics
• Society of Consultants in Reproductive Health
• The Leeds and West Riding Medico-Legal Society
• The Royal Society for Public Health
Honors, Prizes and Awards
• Best Oral free communication Award 2007, Sexual Health & Fertility Control Stream, British International Congress of Obstetrics & Gynaecology, London 2007
• Schering Health Care Award - Best Poster Prize 2002, Faculty of Family Planning & Reproductive Healthcare AGM and Annual Conference, London 2002
• Janssen-Cilag Travelling Scholarship 2001, Faculty of Family Planning & Reproductive Healthcare of the RCOG 2001
• Biographee, Whos Who in Medicine & HealthCare 2000
• Biographee, Marquis, Whos Who in the World 1999
• Research & Development Training Bursary Award 1998, Northern & Yorkshire Regional NHS Executive 1998
• Best Poster Prize, 5th Congress of European, Society of Contraception, Prague, Czechoslovakia 1998
• Organon Laboratories Best Poster Prize, Faculty of Family Planning & Reproductive, Healthcare AGM and Annual Conference, Glasgow: 31 May 1997
• Hope Exchange Programme, Hospital Committee of the European Union for Health Professionals, May - June 1996
• Biographee, International Who is Who in Medicine, Second Edition, 1995, International Biographical Centre, Cambridge, England
• Postgraduate Scholarship Award (Obstetrics & Gynaecology), Ogun State Government of Nigeria 1979
Full Original Peer-Reviewed Publications
1. Gbolade BA. A snap audit of “did not attend” patients in a gynecologic outpatient clinic. Clinical Audit. 2010; 2: 93-96. doi: 10.2147/CA.S9756
2. Wong SS, Thornton GJ, Gbolade B, Bekker HL. A randomised controlled trial of a decision-aid leaflet to facilitate womens choice between pregnancy termination methods. BJOG. 2006; 113(6): 688-694. doi: 10.1111/j.1471-0528.2006.00930.x
3. Wong SS, Bekker HL, Thornton GJ, Gbolade BA. Choices about abortion method: assessing the quality of patient information leaflets in England and Wales. BJOG. 2003; 110: 263-266. doi: 10.1046/j.1471-0528.2003.02390.x
4. Wong SS, Bekker HL, Thornton GJ, Gbolade BA. Assessing the quality of information leaflets about abortion methods in England and Wales.British Journal of Family Planning. 2002; 28(4): 214-215.
5. Gbolade B, Ellis S, Murby B, Randall S, Kirkman R. Bone density in long-term users of depot medroxyprogesterone acetate. Obstetrical & Gynecological Survey. 1999; 53(2): 118-119.
6. Gbolade BA, Elstein M, Yates D. UK accident and emergency departments and emergency contraception: what do they think and do? J Accid Emerg Med. 1999; 16(1): 35-38.
7. Gbolade B, Ellis S, Murby B, Randall S, Kirkman R. Bone density in long-term users of depot medroxyprogesterone acetate (DMPA). BJOG. 1998; 105: 790-794.
8. Gbolade BA. What do accident and emergency departments in the UK think of providing emergency contraception services? Transactions of the North of England Obstetrical & Gynaecological Society. 1996; 6: 12.
9. Sin J, Gbolade BA, Russell A, Chandiok P, Kirkman RJE. Referral-compliance of Chlamydia-positive patients from a family planning clinic. British Journal of Family Planning. 1996; 22(3): 155-156.
10. Gbolade BA, Kirkman RJE, Elstein M. Emergency contraception, weekends and bank holidays: improving access through Cooperation between hospital and community-based services. British Journal of Family Planning. 1996; 22(3): 120-122.
11. Gbolade B, Kirkman, R. Cross-sectional study of bone density in long-term users of depot medroxyprogesterone acetate (DMPA). Advances in Contraception. 1995; 11(1) 59-60.
12. Ghaly AFF, Gbolade BA. Urethrocliesis: treatment for Genuine Stress Incontinence? A retrospective study. Journal of Obstetrics & Gynaecology. 1993; 13(4): 259-261. doi: 10.3109/01443619309151858
13. Makinde OO, Gbolade BA. Traumatic injuries of the lower Female Genital Tract. Tropical Journal of Obstetrics & Gynaecology. 1990; 8(2): 31-33.
Consultant Obstetrician and Gynecologist
Service of Gynecology
Department of Obstetrics and Gynecology
University of Kinshasa
Kinshasa XI, Democratic Republic of Congo
Dr. Emmanuel is a Consultant Obstetrician and Gynecologist and a Senior Researcher in the Department of Obstetrics and Gynecology of the University of Kinshasa, Democratic Republic of Congo. He graduated from the Faculty of Medicine of the University of Kinshasa and was resident at University Hospital of Kinshasa where he obtained his specialization degree in Obstetrics and Gynecology in 2011. His work for this specialization degree was on the itinerary of infertile women seeking care in Kinshasa (Capital of the Democratic Republic of Congo). From this research, he noted that tubal factor, namely fibrosis, was particularly involved in female infertility in sub-Saharan Africa compared with other studies. The question on the participation of pelvic infections, and abdominal and pelvic adhesions arose from his research and led him to undertake research on an eventual predominance of adhesions in black people hypothesizing that Blacks may have an overreaction to aggression in terms of fibrosis compared to other races. He published a preliminary study showing the possible predominance of abdominal and pelvic adhesions in Blacks. He has a Master degree in Public Health from School of Public Health of the University of Kinshasa with a scholarship from the United State Agency for International Development. He is a PhD student of the University of Kinshasa. Dr. Emmanuel has a major interest in tubal factor infertility, tubal surgery, abdominal and pelvic adhesions, principles of surgery, and operative laparoscopy in gynecology.
His research interests include: Abdominal and pelvic adhesions, infertility in sub-saharan women, good practice in surgery.
• Groupe InterAfricain pour la Recherche et l’Application sur la Fertilité (GIERAF)
• Société Congolaise de Gynécologie et Obstétrique (SCOGO)
• International Society for Infectious Diseases (ISID)
1. Nzau NE, Tozin RR, Kamba BM, Tandu-Umba NFB. Imperforate hymen revealed by acute urinary retention: report of a case. Ann Afr Med. 2011; 4(2): 748-753.
2. Mboloko E, Nzau N, Lokengo L. Therapeutic itinerary of infertile women seeking care in Kinshasa. Ann Afr Med. 2011; 4 (4): 855- 864.
3. Nzau NE, Mboloko E, Tandu-Umba NFB, Lokengo LD. Hysterectomy at University Hospital of Kinshasa: from 2002 to 2010. Black African Medicine. 2012; 59 (4): 221 - 230.
4. Nzau NE, Mboloko E, Mbuyi-Muamba JM, Lebwaze MB. Epidemiology, consequences and treatment of peritoneal and pelvic adhesions. A review of the literature. Ann Afr Med. 2012; 5(4): 1187-1200.
5. Nzau NE, Mbuyi-Muamba JM, Mboloko E, Lebwaze MB. Pathophysiology and pathology of peritoneal and pelvic adhesions. A review of the literature. Ann Afr Med. 2012; 6(1): 1294-1306.
6. Mboloko E, Mbangama MA, Lokengo LD, Nzau NE, Bikuelo B, Mboloko M, Mputu L. Infertility in case of polycystic ovary syndrome in a population of Kinshasa. Ann Afr Med. 2013; 6(2): 1328 -1337.
7. Nzau-Ngoma E, Mbuyi-Muamba JM, Mboloko E, Lebwaze MB. Abdominal and pelvic adhesions: Possible role of leiomyomas and skin scar anomaly in profiling high risk patients. Open Journal of Obstetrics and Gynecology. 2014; 4(1): 16-22. doi: 10.4236/ojog.2014.41004
8. Nzau-Ngoma E, Mboloko E, MbuyiMuamba J-M. Abdominal and pelvic adhesions research in Sub-Saharan Africa: air must become wind. Gynecol Obstet Res Open J. 2015; 2(1): e3-e5. 10.17140/GOROJ-2-e002
Department of Obstetrics and Gynecology
Ain Shams University
Kalaifa El-Maamon Str., Cairo, Alqahera11566, Egypt
• Professor of Obstetrics and Gynecology, Ain Shams University, Cairo, Egypt
• Specialist of Obstetrics & Gynecology, Ahmadi Hospital, Kuwait Oil Company (KOC)
• Professor of Obstetrics & Gynecology, Ain Shams University, Cairo, Egypt, since June 2013 till now
• Assistant professor of Obstetrics & Gynecology, Ain Shams University, Cairo, Egypt, since October 2005
• Specialist of Obstetrics & Gynecology, Kuwait, since August 2005
• M.D. degree of Obstetrics & Gynecology, Ain Shams University, Cairo, Egypt, 2000
• Master degree of Obstetrics & Gynecology, Ain Shams University, Cairo, Egypt, 1996
• MB, B.Ch, Ain Shams University, Cairo, Egypt, 1992, grade excellent with honor
His research interests include: Obstetrics and Gynecology, Gynecological malignancies, Laparoscopic surgeries, Urogynecology, Infertility and IVF.
• EAGL (Egyptian Association of Gynecological Laparoscopists)
• ESUG (Egyptian Society of Urogynecology & Pelvic floor)
• AASCIT (American Association for Science and Technology)
1. Abdelazim IA, Elezz AA, Elsherbiny M. Relation between single serum progesterone assay and viability of the first trimester pregnancy. Springer Plus. 2012; 1: 80. doi: 10.1186/2193-1801-1-80
2. Abdelazim IA, Belal MM, Makhlouf HH. Anti-Mullerian hormone and Antral Follicle Count as predictors of ovarian reserve and successful IVF. Evidence Based Womens Health Journal (EBWH). 2012; 1(2): 89-92. doi: 10.1016/S2305-0500(13)60055-X
3. Abdelazim IA, Maha MB. Outcome and uterine arteries Doppler velocimetry after thermal balloon endometrial ablation in menorrhagia. Evidence Based Womens Health Journal (EBWH). 2013; 3(1): 35-38. doi: 10.1097/01.EBX.0000419542.86961.49
4. Abdelazim IA, Elezz AA. Complementary roles of hysteroscopy & saline infusion hysterosonography in uterine cavity assessment before in vitro fertilization. Evidence Based Womens Health Journal (EBWH). 2013; 3(2): 58-63. doi: 10.1016/S2305-0500(13)60040-8
5. Abdelazim IA, Aboelezz A, AbdulKareem AF. Pipelle endometrial sampling versus conventional dilatation & curettage in patients with abnormal uterine bleeding. Journal of the Turkish German Gynaecological Association (JTGGA). 2013; 44: 40-49. doi: 10.5152/jtgga.2013.01
6. Abdelazim IA. Relation between interleukin-6 in cervicovaginal fluid and subclinical chorioamnionitis in patients with preterm premature rupture of membranes. Asian Pacific Journal of Reproduction (APJR). 2013; 2(1): 38-41. doi: 10.1016/S2305-0500(13)60113-X
7. Abdelazim IA, Al-Kadi M, El Shourbagy MM, Mohamed AA, Abu faza ML. Intraperitoneal lidocaine & tenoxicam for pain relief after gynaecological laparoscopy. Asian Pacific Journal of Reproduction (APJR). 2013; 2(2): 146-150. doi: 10.1016/S2305-0500(13)60136-0
8. Yehia AH, Koleib MH, Abdelazim IA, Atik A. Tranexamic acid reduces blood loss during and after cesarean section: A double blinded, randomized, controlled trial. Asian Pacific Journal of Reproduction (APJR). 2014; 3(1): 53-56. doi: 10.1016/S2305-0500(14)60002-6
9. Abdelazim IA, Abdelrazak KM, Al-Kadi M, Yehia AH, Abdulkareem AF. Fetal Fibronectin (Quick Check fFn Test) Versus Insulin-Like Growth Factor Binding Protein-1 (Actim PROM Test) for Detection of Premature Rupture of Fetal Membranes. Journal of Gynaecology and Pediatrics. 2014; 1(1):1-12.
10. Abdelazim IA, Faza MA, Ayash HM.. Effects of raloxifene hydrochloride on bone mineral density and serum lipids in Kuwaiti postmenopausal women with osteoporosis. Journal of Basic and Clinical Reproductive Sciences. 2015; 4(1): 20-23. doi: 10.4103/2278-960X.153518
11. Wreikat S, Khreisat BM, Shwaiyat RA, Abdelazim IA, abu-faza M, Elbiaa AAM. Acceptability and efficacy of levonorgestrel intrauterine device for treatment of menorrhagia. Journal of Basic and Applied Research International.2015; 2(2): 48-56.
12. Abdelazim IA, Faza MLA. Sonographic assessment of the cervical length before induction of labor. Asian Pacific Journal of Reproduction. 2012; 1(4): 253-257. doi: 10.1016/S2305-0500(13)60087-1
13. Abdelazim IA, Abu-Faza M, Sanchez VJ. Iron therapy in treatment of iron deficiency anemia before delivery: intravenous versus oral route. Journal of Gynecology and Obstetric Medicine. 2014. 14. Abdelazim IA, Elbiaa AAM, Al-Kadi M, Yehia AH, Nusair BMS, Faza MA. Maternal and obstetrical factors associated with a successful trial of vaginal birth after cesarean section. Journal of the Turkish German Gynecological Association. 2014; 15(4), 245-249. doi: 10.5152/jtgga.2014.14104
15. Abdelazim IA. Anti-Mullerian hormone and antral follicle count as predictors of ovarian reserve and successful IVF. Asian Pacific Journal of Reproduction (APJR). 2012; 1(2): 89-92. doi: 10.1016/S2305-0500(13)60055-X
16. Abdelazim IA, Elsawah WF. Metabolic syndrome among infertile women with polycystic ovary syndrome. Asian Pacific Journal of Reproduction (APJR). 2015; 4 (1): 44-48. doi: 10.1016/S2305-0500(14)60057-9
1. Kamel H, Abdelazim I, Habib SM, El Shourbagy MA, Ahmed NS. Immunoexpression of matrix metalloproteinase-2 (MMP-2) in malignant ovarian epithelial tumours. J Obstet Gynaecol Can. 2010; 32(6): 580-586. doi: 10.1016/S2305-0500(13)60134-7
2. Abdelazim IA, Abdelrazak KM, Ramy AR, Mounib AM. Complementary roles of prenatal sonography and magnetic resonance imaging in diagnosis of fetal renal anomalies. Australian and New Zealand Journal of Obstetrics and Gynaecology (ANZJ). 2010; 50(3): 237-241. doi: 10.1111/j.1479-828X.2010.01153.x
3. Abdelazim IA. Intrapartum polymerase chain reaction for detection of group B streptococcus colonization. Australian and New Zealand Journal of Obstetrics and Gynecology (ANZJ). 2013; 53(3): 236-242. doi: 10.1111/ajo.12030
4. Abdelazim IA, Makhlouf HH. Placental alpha microglobulin-1 (AmniSure test®) versus Insulin-like growth factor binding protein-1 (Actim PROM test) for detection of premature rupture of fetal membranes. The Journal of Obstetrics and Gynaecology Research (Japan Society of Obstetrics and Gynaecology). 2013; 39(6): 1129-1136. doi: 10.1111/jog.12045
5. Abdelazim IA. Insulin-like Growth Factor Binding Protein-1 (Actim PROM test®) for detection of premature rupture of fetal membranes. Journal of Obstetrics and Gynaecology Research (Japan Society of Obstetrics and Gynaecology). 2014; 40 (4): 961-967. doi: 10.1111/jog.12296
6. Abdelazim IA. Placental alpha microglobulin-1 (AmniSure test®) for detection of premature rupture of fetal membranes. Archives of Gynaecology and Obstetrics. 2012; 285(4): 985-989.
7. Abdelazim IA, Makhlouf HH. Sequential clomiphene citrate/hMG versus hMG for ovulation induction in clomiphene citrate-resistant women. Archives of Gynaecology and Obstetrics. 2013; 287(3): 591-597. doi: 10.1007/s00404-012-2597-7
8. Abdelazim IA. Fetal fibronectin (Quick Check fFN test®) for detection of premature rupture of fetal membranes. Archives of Gynaecology and Obstetrics. 2013; 287(2): 205-210. doi: 10.1007/s00404-012-2548-3
9. Abdelazim IA, Abdelrazak KM, Al-Kadi M, Yehia AH, Abdulkareem AF. Fetal fibronectin (Quick Check fFN test®) versus placental alpha microglobulin-1 (AmniSure test®) for detection of premature rupture of fetal membranes. Archives of Gynaecology and Obstetrics. 2014; 29(3): 457-464. doi: 10.1007/s00404-014-3225-5
10. Abdelazim IA, Abdelrazak KM, Elbiaa AA, Al-Kadi M, Yehia AH.Accuracy of endometrial sampling compared to conventional dilatation and curettage in women with abnormal uterine bleeding. Archives of Gynaecology and Obstetrics. 2014; 291(5):1 121-126. doi: 10.1007/s00404-014-3523-y
11. Abdelazim IA. Effect of Raloxifene hydrochloride on bone mineral density and bone turnover in Kuwaiti postmenopausal women with osteoporosis. Arch Osteop. 2014; 9(1): 189. DOI 10.1007/s11657-014-0189-9 9 (1): 189.
12. Nassar M, Abdelazim IA. Pre-puncture ultrasound guided epidural insertion before vaginal delivery. Journal of clinical monitoring and computing. 2014; doi: 10.1007/s10877-014-9634-y
13. Moniem AMA, Abdelrazak KM, Hussain M, Awadalla AM, Abdelazim IA. Outcomes and accuracy of 2D grayscale ultrasound scan in prenatal diagnosis of morbid adherent placenta. Gynecol Obstet Res Open J. 2015; 2(3): 62-68. doi: 10.17140/GOROJ-2-114
Reproductive Endocrinology and Infertility Section
St. Elizabeth Boardman Family Health
8423 Market St. Suite 101
Boardman, Ohio 44512- 6778, USA
• International College (High School), Beirut, Lebanon Major - Mathematics; graduated with Honors, 1973
• American University of Beirut, Lebanon Major - Biology/Chemistry: BS, 1976
• American University of Beirut Medical Center, Lebanon MD, 1980
His research interests include: Pregnancy rates following conservative CO2-laser surgery for endometriosis, The role of estradiol and progesterone in the pathogenesis of the Premenstrual Syndrome, Screening for osteoporosis by single-photon densitometry, The use of gonatropin-releasing hormone agoinst and estrogen replacement in the treatment of hirsutism, Ultrasound measurement of endometrial thickness and progesterone withdrawal bleeding: A comparative study, Murine embryonic development in serum supplemented normal saline solution, Peritoneal fluid embryotoxicity in endometriosis, Pregnancy induced hypertension and duration of cohabitation, Cervidila vs Prepidila for cervical ripening.
• Recipent of APGO(Association of Professor of Gynocolegy and Obstetrics) Excellence in Teaching Award, (1996)
• Recipent of Outstanding Volunteer Faculty Award, (2001)
• Department of Obstetrics and Gynocolegy, North eastern Ohio Universities College or Medicine
• Member, The American Fertility Society, Birmingham, Alabama
• Member, Sigma Xi, The Scientific Research Society
• Member, The Youngstown Society of Obstetricians and Gynocolegists
• Member, American Academy of Family Practice
1. Marcos RN, Gibbons WE, Findley WE. The effect of peritoneal fluid on in vitro cleavage of 2-cell mouse embryos. Possible role in infertility associated with endometriosis. Fertility and Sterility. 1985; 44: 678.
2. Khawli O, Marcos RN, Stokes G, Bernstine R. Relationship between umbilical cord gasmeasurements, Apgar scores and birth weight . Society of Perinatal Obstetricians, 9th Annual Meeting, New Orleans, Louisiana. 1989.
3. Khawli O, Marcos RN, Stokes G, Bernstine R. Umbilical cord blood gas measurements for term and preterm newborns. Society of Perinatal Obstetrician, 9th Annual Meeting, New Orleans, Louisiana. 1989.
4. Khawli O, Marcos RN, Stokes G, Bernstine R. Spontaneous resolution of preeclampsia and nonimmune hydrops secondary to fetomaternal hemorrhage. Society of Perinatal Obstetrician, 9th Annual Meeting, New Orleans, Louisiana. 1989.
5. Marcos RN, Leonard D, Smith M, Bourguet C, Makii M, Khawli O. Vaginosonographic measurement of endometrial thickness in the evaluation of amenorrhea. Fertility and Sterility. 1991; 55(3): 543-4546. doi: 10.1097/00006254-199203000-00020
6. Marcos RN, Leonard MD, Smith M, Bourguet C, Makii M, Khaw O. Vaginosonographic Measurement of endometrial Thickness in the evaluation of Amenorrhea. In : Mishell D, Kirschbaum T, Marrow C, editors. Yearbook of Obstetrics and Gynecology. St. Louis : Mosby. 1992: 325-327.
7. Caldito G, Marcos RN. Using a logistic model and a generalized logistic model to identify acute pelvic inflammatory disease from clinical indicators. Biometric Soceity(ENAR), Annual Meeting. 1993.
8. Marcos RN, Frost N, Hnat M, Petrunak A, Caldito G. Laparoscopic versus clinical diagnosis of acute pelvic inflammatory disease. Journal of Reproductive Medicine. 1993; 38(1): 53.
9. Marcos RN, Abdul-Malak M, Shikora E. Treatment of hirsutism with a gonadotropin-releasing hormone against and estrogen replacement therapy. Fertility and Sterility. 1994; 61(3): 427-431.
10. Marcos RN, Frost N, Hnat M, Petrunak A, Caldito G. Laparoscopic versus clinical diagnosis of acute pelvic inflammatory disease. In: Mishell D, Kirschbaum T, Marrow C, editors. Yearbook of Obstetrics and Gynecology. St. Louis : Mosby. 1994; 398-399.
11. Marcos RN, Bourguet C, Gill P, Khawli O, et al. Pregnancy-Induced Hypertension and Duration of Sexual CohibationC. The Journal of Reproductive Medicine. 2000; 45: 207-212.
12. Marcos RN, Kizy T. When is treatment indicated? The Journal of Family Practice. 2012; 61(12).
University of Technology, Sydney (UTS)
University of New South Wales (UNSW)
Prof. Lim graduated from the UNSW and he is a Medical Practitioner, University Academician and a well-known media personality in the Chinese community in Sydney. He is a Registered Medical Practitioner and Registered Chinese Medicine Practitioner in Australia. He is an Adjunct Professor at the University of Technology, Sydney (UTS) as well as a conjoint appointee at the University of New South Wales (UNSW) Australia. In terms of his clinical profile, Prof. Lim works in Palliative Medicine and Family Medicine. He is a member of RACGP, RACP, RACMA, ACHSM, etc. Academically, Prof. Lim has completed several postgraduate studies at master and doctoral level in Australia and has published more than 70 journal articles since 2008 as well as being a reviewer/editorial board member (including Editor in Chief) for more than 28 different peer reviewed journals. He received full scholarship support from UNSW for his PhD (Medicine) study on Polycystic Ovarian Syndrome (PCOS), He has also completed his second doctorate study in Business Administration. For his PCOS study, he has also performed the first acupuncture RCTs on PCOS and he is also the author for the Cochrane Titles of Acupuncture & PCOS, as well as the Chinese herbal medicine & PCOS.
His research interest include: PCOS, Reproductive Medicine, CAM and Palliative Medicine.
• Royal Australasian College of Medical Administrators
• Royal Australasian College of Physicians
• Royal Australian College of General Practitioners
• Royal Society of Medicine, United Kingdom
• Australian College of Health Service Management
• Australasian College of Nutritional & Environmental Medicine
• Australian College of Educators
• Australian Medical Acupuncture College
• Australian Chinese Medical Association
• Australasian Council of Chinese Medical Associations
• Chinese Medicine & Acupuncture Society of Australia
• Australian Natural Therapists Association
• Australian Traditional-Medicine Society
• Australian Institute of Medical Scientists
• Australian Medical Association
• Australian & New Zealand Society of Palliative Medicine
• NSW Palliative Care
• Polycystic Ovarian Syndrome Association of Australia
1. Lim CED, Cheng NCL, Lengacher CA. Effect of mindfulness based stress reduction in stage 0-III breast cancer survivors. Focus on Alternative and Complementary Therapies. 2014; 19(4): 219-220. doi: 10.1111/fct.12135
2. Cheng NCL, Xu K, Huang Y, Lim CED. Optimum antibiotic doses for Helicobacter pylori eradication (Protocol). Cochrane Database of Systematic Reviews. 2014; 7 . doi: 10.1002/14651858.CD011187
3. Siow S, Lim DE, Cheng L, Zaslawski C, Wiltshire J, Strutt R. What Do The Junior Doctors Kw About Pain Management And Opioids Use? : An Australian Study. Journal of Geriatrics and Palliative Care. 2014; 2(2): 1-9.
4. Lim CED, Cheng NCL. What do we know about needling sensation (de qi) and Bells palsy outcome? Focus on Alternative and Complementary Therapies. 2014; 19(1): 34-35. doi: 10.1111/fct.12083
5. Ng RWC, Lim CED, Cheng NCL. Multiple Art ralgia After Use of Amoxicillin in EBV Infection: Could it be Adult Onset of Stills Disease? Journal of Medical Cases. 2014; 5(2) 105. doi: http://dx.doi.org/10.14740/jmc1661w
6. Huang, Y, Lim CED, Cheng NCL, Whiltshire J, Strutt R, Zaslawski C. Specialty Trainees? Understanding of End-of-Life Care Symptom Management and End-of-Life Care Pathway: A Quantitative and Qualitative Pilot Study. Journal of Geriatrics and Palliative Care. 2(1): 1-9.
7. Lim CED, Wong WSF. Therapeutic Management of Vaginal Intraepithelial Neoplasia and Clinical Experience in South Western Sydney of Australia. International Journal of Gynecological and Obstetrical Research. 2014; 2013(1): 36-41. doi: http://dx.doi.org/10.14205/2309-4400.2013.01.01.6
8. Zhu X, Lim CE, Nagels HE. Acupuncture for female subfertility. Cochrane Database of Systematic Reviews. 2013; 3. doi: 0.1002/14651858.CD010462
9. Lim CE, Ng RWC, Lim CED, et al. Number and Necessity of Tests Performed In the Last Week of Life of a Cancer Patient. Journal of Geriatrics and Palliative Care. 2013; 1(1): 1-5.
10. Lim CED, Ho KKW, Cheng NCL, Wong FWS. Combined oestrogen and progesterone for preventing miscarriage. Cochrane Database of Systematic Reviews. 2013; 9. doi: 10.1002/14651858.CD009278.pub2
11. Lim CED, Cheng NCL. Electroacupuncture for symptom improvement in benign prostatic hyperplasia. Focus on Alternative and Complementary Therapies. 2013; 18(4):199 -200. doi: 10.1111/fct.12069
12. Lim CED, Ng RWC, Xu K. Non-hormonal methods for induction of labour. Current Opinion in Obstetrics and Gynecology. 2013; 25(6): 441 -447. doi: 10.1097/GCO.0000000000000027
13. Lim CED, Cheng NCL. Acupuncture for allergic rhinitis: active and sham acupuncture both seem to work. Focus on Alternative and Complementary Therapies. 18(3): 136-137. doi: 10.1111/fct.12046
14. Wong FWS, Lim DCE. Factors influencing the choice of hysterectomy aroach for the management of fibroid uterus. Gynecology and Minimally Invasive Therapy. 2013; 2(2): 61- 64. doi: 10.1016/j.gmit.2013.02.004
15. Lim CED, Cheng NCL. Massage therapy to improve sleep quality post coronary artery bypass graft surgery. Focus on Alternative and Complementary Therapies. 2012; 17(1): 67-68. doi: 10.1111/j.2042-7166.2011.01138_13.x
16. Lim CED, Cheng NCL. Connective tissue reflex massage to improve peripheral circulation in type 2 diabetes mellitus. Focus on Alternative and Complementary Therapies. 2012; 17(1): 69 -70.
17. Luo X, Hong XS, Xiong XD, Zeng LQ, Lim CED. 2012 A Single Nucleotide Polymorphism in EXO1 Gene Is Associated With Cervical Cancer Susceptibility in Chinese Patients. International Journal of Gynecological Cancer . 2012; 22( 2): 220-225.
18. Pan M, Ye N, Chen Z, Gu C, Lim DCE. Observation of infiltration and activation of dendritic cells in primary foci of prostate cancer using fuzhengyiliufa integrative treatments. Journal of the Australian Traditional-Medicine Society. 2012; 8( 3): 151-154.
19. Lim DCE, Wong FWS, Cheng NCL. Xiao Shan Zhu Lin Sis Secret Gynaecological Chinese Medicinal Formulae ? Graling with ancient disease in modern times: a commentary by two western gynecological practitioners. Journal of the Australian Traditional-Medicine Society. 2012; 18(1): 27-29.
20. Lim DCE, Ng R, Chen W, Cheng NCL, Zaslawski C, Li X. Acupuncture for primary hypercholesterolaemia. Cochrane Database of Systematic Reviews. 2012; 12. doi: 10.1002/14651858.CD010286
21. Lim DCE, Cheng LL, Zahid S, Wong FWS. Prostaglandin A for treating pre-eclampsia. Cochrane Database of Systematic Review. 2012; 2. doi: 10.1002/14651858.CD009657
22. Zhang X, Ye N, Pan M, Lim CED. Preventive treatment for diseases: A practice model. A challenge for hospital management in the field of integrative medicine. Journal of the Australian Traditional-Medicine Society. 2012; 18(4): 221- 223.
23. Lim CE, Cheng NCL. Clinicians Role of Psychological Suort in Helping Parents and Families with Pregnancy Loss. Journal of the Australian Traditional-Medicine Society. 2011; 17(4): 215-218.
24. Lim CED, Wong FWS, Smith W. Factors influencing the bio-impedance data in tissue segments along the three arm meridians: a pilot study. TANG. 2011; 1(1): 71-79.
25. Wong WSF, Lim CED, Luo X. Inguinal Endometriosis: An Uncommon Differential Diagsis as an Inguinal Tumour. ISRN Obstetrics and Gynecology . 2011; 2011: 1 -4.
26. Chen W, Lim CED, Kang H-J, Liu J. Chinese Herbal Medicines for the Treatment of Type A H1N1 Influenza: A Systematic Review of Randomized Controlled Trials. PLoS One. 2011; 6(12): e28093 - e28093.
27. Wong WSF, Lee TCE, Lim CED. A retrospective study of laparoscopic-assisted vaginal hysterectomy (LAVH) in virgins and nulliparae. European Journal of Obstetrics Gynecology and Reproductive Biology. 2011; 157(2): 217 -221. doi: 10.1016/j.ejogrb.2011.03.018
28. Wang Y, Luo X-P, Lim CED, Wong WSF, Zhong G. Regulatory Effect of Peptidoglycan on the Expression of Toll-Like Receptor 2 mRNA and Proteins in Trophoblast Cell Line TEV-1 Cells. ISRN Obstetrics and Gynecology . 2011: 1 -5. doi: 10.5402/2011/692858
29. Lim DCE, Cheng LL, Ho K, Wong FWS. Combined oestrogen and progesterone for preventing miscarriage. Cochrane Database of Systematic Reviews. 2011; 8: CD009278. doi: 10.1002/14651858.CD009278.pub2
30. Lim DCE, Zaslawski C. n-specific effects of acupuncture: Genuine or placebo?. Focus on Alternative and Complementary Therapies. 2011; 16(3): 221-222.
31. Lim DCE, Cheng NL. Obesity and reproduction. Journal of the Australian Traditional-Medicine Society. 2011; 17(3): 143-145.
32. Lim DCE, Chen W, Cheng NL, et al. Acupuncture for polycystic ovarian syndrome. Cochrane Database of Systematic Reviews. 2011; 10(8): 1-18.
33. Wong WF, Lim DCE. Hormonal treatment for endometriosis associated pelvic pain. Iranian Journal of Reproductive Medicine. 2011; 9 (3): 163 -170.
34. Lim DCE, Liu J. Traditional Chinese medicine for gynaecological diseases. Journal of the Australian Traditional-Medicine Society . 2011; 17(1): 17-23.
35. Lim D, Chen WM, Lian XF. Clinical trials of TCM and Parkinsons disease in China. Focus on Alternative and Complementary Therapies. 2010; 15(4): 312- 313. doi: 10.1111/j.2042-7166.2010.01057_15.x
36. Zeng L, Lee W, Lim CE, Ye V, Wong F. Present Status and Trends in Surgical Management of Ectopic Pregnancy in Australia. Chinese Journal of Minimally Invasive Surgery. 2010; 10(3): 197-200.
37. Lim CE. Acupuncture for Chronic Neck Pain. Focus on Alternative and Complementary Therapies An Evidence-Based Aroach. 2010; 15(4): 294 296.
38. Lim CE. Acupuncture for pain and agitation associated with grommet insertion. Focus on Alternative and Complementary Therapies An Evidence-Based Aroach . 2010; 15(2): 133 -134. doi: 10.1211/fact.15.2.0021
39. Lim CE, Wong F, Cheng NCL, Chow M, OSullivan A. Current evidence of Complementary & Alternative Medicine in Management of Syndrome X. Journal of the Australian Traditional-Medicine Society. 2010; 16(4): 209-214.
40. Wong FWS, Lim CED, Smith W. A New Bioimpedance Research Device (BIRD) for Measuring the Electrical Impedance of Acupuncture Meridians. Journal of Alternative and Complementary Medicine. 2010; 16(3): 257-264. doi: 10.1089/acm.2009.0218
41. Wong WSF, Lee TCE, Lim CED. vel Vaginal ?Paper Roll? Uterine Morcellation Technique for Removal of Large (>500 g) Uterus. Journal of Minimally Invasive Gynecology. 2010; 17(3): 374-378.
42. Luo X, Lim CED, Li L, Wong WSF. Hysteroscopic Aearance of Endometrial Cavity after Microwave Endometrial Ablation. Journal of Minimally Invasive Gynecology . 2010; 17(1): 30-36. doi: 10.1016/j.jmig.2009.09.012
43. Lim CED, Wong WSF. Current evidence of acupuncture on polycystic ovarian syndrome. Gynecological Endocrilogy. 2010; 26(6): 473-478. doi: 10.3109/09513591003686304.
44. Wong FWS, Lim CED, Karia S, Santos L. Cervical endometriosis: Case series and review of literature. Journal of Obstetrics and Gynaecology Research. 2010; 36(4): 916- 919. doi: 10.1111/j.1447-0756.2010.01209.x
45. Lim DCE, Cheng NL, Chow Y, Wong WF, O Sullivan AJ. Complementary and alternative medicine for metabolic syndrome. Journal of the Australian Traditional-Medicine Society. 2010; 16(4): 209-214.
46. Lim CE, Wong F, Wong V. Mepausal Syndrome: An integrative East meet West aroach. The Journal of Complementary Medicine: the independent peer-reviewed. journal for healthcare professionals. 2009; 8(2): 55- 60.
47. Lim CE. Effectiveness of acupuncture on hot flushes and health related quality of life in postmepausal women. Focus on Alternative and Complementary Therapies An Evidence-Based Aroach. 2009; 14(3): 195 -196.
48. Lim CE. Randomised Acupuncture Trial on Relieving Labour Pain. Focus on Alternative and Complementary Therapies An Evidence-Based Aroach. 2009; 14(3): 202 -203.
49. Lim CE. Two further studies investigating the impact of acupuncture on pregnancy outcome of in vitro fertilisation treatment. Focus on Alternative and Complementary Therapies An Evidence-Based Aroach . 2009; 14(1): 37-39. doi: 10.1111/j.2042-7166.2009.tb01870.x
50. Lim CE, Luo XP, Zhan XL, Wong WSF. Clinical Observation of Chinese Medicine Treatment on Secondary Dysmerrhoea Associated with Endometriosis. Australian Journal of Acupuncture and Chinese Medicine. 2009; 4(2): 12-17.
51. Lim CE, Wong F. Syndrome X. The Journal of Complementary Medicine: the independent peer-reviewed journal for healthcare professionals. 2009; 8(6): 39-40.
52. Lee ETC, Wong FWS, Lim CED. A Modified Technique of LAVH with the Biswas Uterovaginal Elevator. Journal of Minimally Invasive Gynecology. 2009; 16(6): 755-760. doi: 10.1016/j.jmig.2009.07.021
53. Lim CED, Wilkinson JM, Wong WSF, Cheng NCL. Effect of Acupuncture on Induction of Labor. Journal of Alternative and Complementary Medicine. 2009; 15(11): 1209 -1214. doi: 10.1089/acm.2009.0100
54. Lim DCE, Cheng LNC, Wong FWS. Could it be Hech-Schönlein purpura? Australian Family Physician. 2009; 38(5): 321-324.
55. Lim CED, Yii MF, Cheng NCL, Chow YKM. The role of micronutrients in pregnancy. Australian Family Physician. 2009; 38(12): 980-984.
56. Lim D, Wong WF, Wong V. Mepausal syndrome. The Journal of Complementary Medicine: the independent peer-reviewed journal for healthcare professionals. 2009; 8: 55-57.
57. Wong WF, Lin L, Lim DC. Drug and herb interactions: Searching the web. Australian Family Physician. 2009; 38(8): 627-633.
58. Lim CE. Dry Mouth. The Journal of Complementary Medicine: the independent peer-reviewed journal for healthcare professionals. 2008; 7(4): 48-49.
59. Lim DS. Dry mouth. The Journal of Complementary Medicine: the independent peer-reviewed journal for healthcare professionals. 2008; 7(48-49): 54.
Department of Obstetrics & Gynecology
Boonshoft School of Medicine
Wright State University
3640 Colonel Glenn Hwy
Dayton, OH 45435, USA
Dr. Lindheim is Professor of Obstetrics and Gynecology and the Program Director of the Reproductive Endocrinology and Infertility program at Wright State University, Boonshoft School of Medicine. He graduated from Temple School of Medicine and was a resident at Pennsylvania Hospital in Philadelphia. Dr. Lindheim completed a fellowship in Reproductive Endocrinology and Infertility at the University of Southern California, and is currently Board Certified in both Ob/Gyn and Reproductive Endocrinology and Infertility. He has his masters in medical management at Tulane Tropical School of Medicine. He has most recently served as a faculty member at University of Cincinnati. Dr. Lindheim has a major interest in In vitro fertilization, oocyte donation, embryo donation, reproductive ethics, opertive laparoscopy and hysteroscopy. He is a well-recognized expert in the field of assisted reproduction and has over 100 scientific publications. His research focuses upon in-vitro fertilization, PCOS, and endometriosis integrating with translational genomics and secretomics.
His research interests include: In vitro fertilization, oocyte donation, embryo donation, reproductive ethics, opertive laparoscopy and hysteroscopy.
• American College of Obstetrics and Gynecology
• American College of Physician Executives
• American Society of Reproductive Medicine
• Associate Member, Society For Gynecologic Investigation
• Dayton OB-GYN Society
• Society For Assisted Reproductive Technology
• The Chicago Gynecologic Society (Honorary member)
• The Society for Androgen Excess Disorders
• The Society for Reproductive Endocrinology & Infertility
• The Society For Reproductive Surgeons
• American Board of Obstetrics and Gynecology, 1991
• American Board of Obstetrics and Gynecology, Subspecialty Board, Reproductive Endocrinology, 1996 (Recertification-1999, 2002-2013)
1. Levine SB, Lerner HJ, Leifer ED, Lindheim SR. Intraoperative cholangiography: A review of indications and analysis of age sex groups. Ann Surg. 1983; 198: 692-697.
2. Rando RF, Lindheim SR, Hasty L, Sedlacek TV, Woodland M, Eder C. Increased frequency of detection of human papilloma virus deoxyribonucleic acid in exfoliated cervical cells during pregnancy. Am J Obstet Gynecol. 1989; 161: 50-54. doi: : http://dx.doi.org/10.1016/0002-9378(89)90231-7
3. Sedlacek TV, Lindheim SR, Eder C, et al. Mechanism for human papillomavirus transmission at birth. Am J Obstet Gynecol. 1989; 161: 55-59. doi: http://dx.doi.org/10.1016/0002-9378(89)90232-9
4. Lindheim SR, Smith Nguyen G. Aggressive evaluation for atypical squamous cells in Papanicolaou smears. J Reprod Med. 1989; 35: 971-973.
5. Lindheim SR, Legro RS, Bernstein L, et al. Behavioral stress responses in premenopausal women and the effects of estrogen. Am J Obstet Gynecol. 1992; 167: 1831-1836. doi: http://dx.doi.org/10.1016/0002-9378(92)91783-7
6. Lindheim SR, Pressor SC, Ditkoff EC, Vijod MA, Stanczyk FZ, Lobo RA. A possible bimodal effect on insulin sensitivity in postmenopausal women and the attenuating effect of added progestin. Fertil Steril. 1993; 60: 664-667.
7. Lindheim SR, Notelovitz M, Feldman EB, Larsen S, Khan FY, Lobo RA. The independent effects of exercise and estrogen on lipids and lipoproteins in postmenopausal women. Obstet Gynecol. 1994; 83: 167-170.
8. Kojima T, Lindheim SR, Duffy DM, Vijod MA, Stanczyk FZI, Lobo RA. Insulin sensitivity is decreased in normal women by doses of ethinyl estradiol used in oral contraceptives. Am J Obstet Gynecol. 1994; 169: 1540-1544. doi: http://dx.doi.org/10.1016/0002-9378(93)90432-I
9. Lindheim SR, Legro RS, Morris RS, et al. The effect of progestin on behavioral stress responses in postmenopausal women. J Soc Gyn Invest. 1994; 1: 79-83. doi: 10.1177/107155769400100116
10. Lindheim SR, Buchanan TA, Duffy DM, et al. Comparison of estimates of insulin sensitivity in pre and post menopausal women using the insulin tolerance test and the frequently sampled intravenous glucose tolerance test. J Soc Gyn Invest. 1994; 1: 150-54.
11. Lindheim SR, Duffy DM, Kojima T, Vijod MA, Stanczyk FZ, Lobo RA. The route of administration influences the effect of estrogen on insulin sensitivity in postmenopausal women. Fertil Steril. 1994; 62: 1176-1180.
12. Duffy DM, Lindheim SR, Vijod MA, Chang L, Nakamura RM, Lobo RA. Low- dose hormone-releasing factor may enhance folliculogenesis in regularly menstruating women: a preliminary study. Fertil Steril. 1995; 63: 756-760.
13. Morris RS, Paulson Lindheim SR, Legro RS, Lobo RA, Sauer MV. Angiotensin-converting enzyme inhibition reverses luteal phase steroid production in oocyte donors. Fertil Steril. 1995; 63: 854-858.
14. Lindheim SR, Legro RS, Morris RS, et al. Altered stress responses in women undergoing in vitro fertilization and recipients of oocyte donation. Human Reprod. 1995; 10: 320-323.
15 Witt B, Barad DH, Barg P, et al. Basal Serum Follicle Stimulating Hormone (FSH) and Estradiol Levels as Predictors of Pregnancy in Unstimulated Donor Insemination Cycles. J Assis Reprod Genet. 1995; 12: 157-160.
16. Lindheim SR, Sauer MV, Francis MM, Macaso TM, Lobo RA, Paulson RJ. The significance of elevated early follicular phase phase FSH levels in unstimulated cycles: Effects of follicular dynamics and oocyte maturation. J Assis Reprod Genet. 1995; 13: 49-52.
17. Wong IL, Legro RS, Lindheim SR, Paulson RJ, Sauer MV. Efficacy of oocytes donated by older women in an oocyte donation program. Human Repro. 1996; 11: 820-823.
18. Lindheim SR, Barad DH, Zinger M, et al. Abnormal sperm morphology is highly predictive of pregnancy outcome during controlled ovarian hyperstimulation and intrauterine insemination. J Assis Reprod Genet. 1996; 13: 569-572. doi: 10.1007/BF02066610
19. Lindheim SR, Barad DH, Witt B, Ditkoff E, Sauer MV. Short-term gonadotropin suppression with oral contraceptives benefits poor responders prior to controlled ovarian hyperstimulation. J Assis Reprod Genet. 1996; 13: 745-747. doi: 10.1007/BF02066431
20. Lindheim SR, Sauer MV, Francis MM, Macaso TM, Lobo RA, Paulson RJ. The utility of a midcycle FSH boost in addition to hCG for timing of follicle aspiration in unstimulated IVF cycles. Gynecol Obstet Invest. 1997; 43: 76-78.
21. Lindheim SR, Ditkoff EC, Vidali A, Zinger M, Sauer MV. Poor responders to ovarian hyperstimulation may benefit from an attempt at natural cycle oocyte retrieval. J Assis Reprod Genet. 1997; 14: 174-176. doi: 10.1007/BF02766136
22. Ditkoff EC, Prosser R, Zimmerman RC, Lindheim SR, Sauer MV. The addition of norethindrone acetate to leuprolide acetate for ovarian suppression has no adverse effect on ovarian stimulation. J Assis Reprod Genet. 1997; 14: 92-96. doi: 10.1007/BF02765777
23. Ditkoff EC, Tucker T, Longacre T, Levine RU, Lindheim SR, Sauer MV. Bilateral serous cystadenofibromas clinically simulating hypereacto luteinalis following controlled ovarian hyperstimulation and in vitro fertilization. J Assis Reprod Genet. 1997; 14: 230-233. doi: 10.1007/BF02766116
24. Lindheim SR, Ditkoff EC, Zinger M, Sauer MV. Differences in ovarian stimulation among older and younger women with a diminished gonadal reserve. J Assis Reprod Genet. 1997; 14: 235-237. doi: 10.1007/BF02766118
25. Lindheim SR, Heller D, Ditkoff EC, Sauer MV. Ovarian hyperstimulation compounds the deleterious effects of hydrosalpinx on outcome during IVF-ET. J Assis Repro Rev. 1997; 6: 64-66.
26. Lindheim SR, Vidali A, Timor-Tritsch I, Sauer MV. A complicated case of medically managed ectopic pregnancy following ovum donation. J Assis Reprod Genet. 1997; 14: 291-293.
27. Lindheim SR, Chang PL, Ditkoff EC, Sauer MV. Increases in serum progesterone after human chorionic gonadotropin are not predictive of cycle outcome during IVF-ET. J Assis Repro Rev. 1997; 7: 134-136.
28. Lindheim SR, Chang PL, Ditkoff EC, Sauer MV. The utility of day 3 FSH and estradiol in women with PCOS undergoing ovarian hyperstimulation and IUI. J Assis Repro Rev. 1997; 7: 137-138.
29. Koopersmith T, Lindheim SR, Lobo RA, Paulson RA, Sauer MV. Outcomes of higher order multiple gestations in women undergoing ovum donation. J Mat-Fet Med. 1997; 6: 268-272.
30. Lindheim SR, Sauer MV. The clinical utility of hysterosonography for upper genital tract screening in patients undergoing ovum donation. J Gynecol Obstet. 1998; 60: 47-50.
31. Lindheim SR, Frumovitz M, Sauer MV. Recruitment and screening policies and procedures used to establish a paid donor oocyte registry. Hum Reprod. 1998; 13: 2020-2024.
32. Chang PL, Lindheim SR, Sauer MV. Screening oocyte donors for cystic fibrosis using multiplex PCR amplification of CFTR gene from buccal cell DNA. J Assis Reprod Genet. 1998; 15: 405-406. doi: 10.1023/A:1022545319395
33. Lindheim SR, M Sauer MV. Attitudes among recipient couples awaiting anonymous oocyte donation matching. J Assis Reprod Genet. 1998; 15: 444-446.
34. Lindheim SR, Chang PL, Vidalli A, Ferrin M, Sauer MV. The utility of serum progesterone and inhibin A in monitoring unstimulated IVF-ET cycles. J Assis Reprod Genet. 1998; 15: 538-541. doi: 10.1023/A:1022530103330
35. Lindheim SR, Cohen MA, Sauer MV. Operative ultrasonography for upper genital tract pathology: a new application for sonohysterography. J Assis Reprod Genet. 1998; 15: 542-546. doi: 10.1023/A:1022582120168
36. Stadtmauer L, Vidalli A, Lindheim SR, Sauer MV. Follicular fluid insulin-like growth factor-1 and insulin-like binding protein-1 and -3 vary as a function of ovarian reserve and ovarian stimulation. J Assis Reprod Genet. 1998; 15: 587-593.
37. Lindheim SR. Chronic Pelvic Pain: Presumptive diagnosis and therapy using GnRH-agonists. Int J Fertil Women.s Med. 1998; 43: 1-10.
38. Lindheim SR, Sauer MV. Trophoblast Persists Despite Lack of Sex-Steroid Support Following Ovum Donation. J Assis Reprod Genet. 1999; 16: 52-54. doi: 10.1023/A:1022501830531
39. Cohen MA, Langer JL, Lindheim SR, Brown S, Sauer MV. Genetic screening of oocyte donors. Asst Reprod Rev. 1999; 9: 45-49.
40. Surrey ES, and the Add-Back Consensus Working Group. Add-back therapy and gonadotropin-releasing hormone agonists in the treatment with endometriosis: can a consensus be reached? . Fertil Steril. 1999; 71: 420-424. doi: http://dx.doi.org/10.1016/S0015-0282(98)00500-7
41. Lindheim SR, Sauer MV. Breast cancer in an ovum donor. J Assis Reprod Genet. 1999; 16: 108-110.
42. Cohen MA, Lindheim SR, Sauer MV. Hydrosalpinges adversely affects implantation in donor oocyte cycles. Hum Reprod. 1999; 14: 1087-1089. doi: 10.1093/humrep/14.4.1087
43. Cohen MA, Keltz M, Sauer MV, Lindheim SR. Utilizing routine sonohysterography to detect intrauterine pathology prior to initiating hormone replacement therapy. J Menopause. 1999; 6: 68-70.
44. Cohen MA, Lindheim SR, Sauer MV. Avoiding Pachyonychia Congenita using oocyte donation. J Derm. 1999; 198: 107-108. doi: 10.1159/000018083)
45. Cohen MA, Chang PL, Legro R, Uhler M, Sauer MV, Lindheim SR. Reproductive outcome after sterilization in women of advanced reproductive age. J Assis Reprod Genet. 1999; 16: 402-404. doi: 10.1023/A:1020509323039
46. Lindheim SR, Cohen M, Sauer MV. Compensated inhibin-a production by the dominant follicle in natural IVF-ET cycles in women with diminished ovarian reserve. J Assis Reprod Genet. 1999; 8: 450-453.
47. Lindheim SR, Cohen MA, Sauer MV. Ultrasound guided embryo transfer significantly improves pregnancy outcome in women undergoing ovum donation. Int J Gynecol Obstet. 1999; 66: 281-284. doi: http://dx.doi.org/10.1016/S0020-7292(99)00077-6
48. Cohen MA, Lindheim SR, Sauer MV. An unusual case of 21-hydroxylase deficiency in a Turner.s patient undergoing oocyte donation. Fertil Steril. 1999; 72: 937-939.
49. Lindheim SR, Sauer MV. Embryo donation: A programmed approach. Fertil Steril. 1999; 72: 940-941. doi: http://dx.doi.org/10.1016/S0015-0282(99)00361-1
50. Cohen MA, Lindheim SR, Sauer MV. Donor age is paramount to success in oocyte donation. Hum Reprod. 1999; 14: 255-258. doi: 10.1093/humrep/14.11.2755
51. Lindheim SR, Cohen M, Chang PL, Sauer MV. Significant differences in serum progesterone before and after human chorionic gonadotropin based on response to controlled ovarian hyperstimulation during IVF-ET cycles. J Assis Reprod Genet. 1999; 16: 242-246. doi: 10.1023/A:1020311328182
52. Lindheim SR, Cohen MA, Sauer MV. Intra-operative Applications Of Saline Infusion Ultrasonography. J Assis Reprod Genet. 1999; 16: 390-394. doi: 10.1023/A:1020502232184
53. Scialli AR. For the Pelvic Pain Expert Working Group. Evaluating Chronic Pelvic Pelvic Pain: A consensus Recommendation. J Reprod Med. 1999; 44: 945-952.
54. Lindheim SR, Kavic S, Shulman SV, Sauer MV. Operative hysteroscopy in the office setting. J Am Lapros Surg. 2000; 7: 31-35.
55. Lindheim SR, Sauer MV, Carmina E, et al. Circulating Leptin During Ovulation Induction: Relationship To Adiposity and Ovarian Morphology. Fertil Steril. 2000; 73: 493-498. doi: http://dx.doi.org/10.1016/S0015-0282(99)00578-6
56. Chang PL, Lindheim SR, Ferrin M, et al. Normal ovulatory women with polycystic ovaries have hyperandrogenic pituitary-ovarian responses to gonadotropin releasing hormone-agonist testing. J Clin Endocrinol Metab. 2000; 85: 995-1000. doi: http://dx.doi.org/10.1210/jcem.85.3.6452
57. Kavic S, Sauer MV, Lindheim SR. Lessons learned from centralized oocyte donation. Advances in Reproduction. 2000; 4: 11-14.
58. Lindheim SR, Cohen MA, Sauer MV. The effect of ICSI on frozen thawed embryos generated from donor oocytes. Advances in Reproduction. 2000; 4: 238-243.
59. Lindheim SR, Kavic S, Sauer MV. Understanding differences in the perception of anonymous parties: A comparison between gamete donors and their recipients. J Assis Reprod Genet. 2000; 17: 127-130.
60. Kavic S, Lindheim SR, Sauer MV. Menses predict successful ovarian down-regulation using GnRH-a prior to IVF-ET cycles. J Assis Reprod Genet. 2000; 17: 296-298. doi: 10.1023/A:1009418618455
61. Lindheim SR. Echosight Jansen-Anderson Coaxial catheter guided hysteroscopy. J American Assoc Gynecol Laparoscopists. 2001; 8: 307-311.
62. Lindheim SR, Fisch H, Sauer MV. TESA and its application to oocyte donation. Advances in Reproduction. 2001; 46: 211-215. doi: 10.1080/01485010151096522
63. Kavic S, Cohen MA, Sauer MV, Lindheim SR. The predictive value of serum estradiol early in the course of controlled ovarian hyperstimulation in women undergoing oocyte donation. J Reprod Med. 2001; 46: 637-640.
64. Mor E, Lindheim SR, Lerner J, Sauer MV. Combined intrauterine. tubal. and cervical pregnancies following in vitro fertilization and embryo transfer. J Assist Reprod Gen. 2001; 18: 349-351.
65. Lindheim SR, Chase J, Sauer MV. Assessing the influence of payment on motivations of women participating as oocyte donors. Gynecol Obstet Invest. 2001; 52: 89-92. doi: 10.1159/000052949
66. Kovalevskaya G, Birken S, Kakuma T, et al. Prediction of IVF pregnancy outcome by the differential expression of hCG glycosylation isoforms: Preliminary characterization of the hyperglycosylated epitope. J Endo. 2002; 172: 497-506.
67. Lindheim SR, Morales AJ. Comparisons of Sonohysterography to Hysteroscopy: Lessons Learned and Avoiding Pitfalls. J American Assoc Gynecol Laparoscopists. 2002: 9: 223-231. doi: 10.1016/S1074-3804(05)60138-7
68. Lindheim SR, Morales AJ. Operative Ultrasound Using an Echogenic Loop Snare For Intrauterine Pathology. J American Assoc Gynecol Laparoscopists. 2003; 10(1): 107-110.
69. OliveDL, Lindheim SR, Pritts EA. Endometriosis and Infertility: What Do We Do For Each Stage? Current Women.s Health Report. 2003; 3(5): 389-394.
70. Lindheim SR, Morales AJ. GnRH-antagonists followed by a decline in serum estradiol results in adverse outcomes in donor oocyte cycles. Human Reproduction. 2003; 18(10): 2048-2051. doi: 10.1093/humrep/deg407
71. Lindheim SR, Adsuar N, Kushner DM, Pritts EA, Olive DL. Sonohysterography: A valuable in tool in evaluating the female pelvis. Obstet Gynecol Survey. 2003; 58(11): 770-784. doi: 10.1097/00006254-200311000-00025
72. Olive DL, Lindheim SR, Pritts EA. Non-Surgical Management of Leiomyoma: Impact on Fertility. Curr Opinion Obstet Gynecol. 2004; 16: 239-243.
73. Olive DL, Lindheim SR, Pritts EA. New medical treatments for endometriosis. Best Practice & Research Clinical Obstetrics and Gynecology. 2004: 18(2): 319-328.
74. Adsuar N, Zweifel J, Pratt E, Davidson M, Olive DL, Lindheim SR. Assessment of wishesregarding disposition of oocytes and embryo management among ovum donors in an anonymous egg donation program. Fertil Steril. 2005; 84(5): 513-516.
75. Lindheim SR, Spraque C, Winter TC. Hysterosalpingography and Sonohysterography Lessons Learned from The Gynecologist. American Journal of Roentgenology (AJR). 2006; 186(1): 24-29.
76. Wei AY, Schink JC, Pritts EA, Olive DL, Lindheim SR. Saline contrast sonohysterography and directed extraction, resection and biopsy of intrauterine pathology using a Uterine Explora Curette. Ultrasound Obstetrics Gynecology. 2006; 27(2): 202-205. doi: 10.1002/uog.2599
77. Zweifel J, Rathert MA, Klock S, et al. Comparative Assessment of Pre and Post-Donation Attitudes With Respect to Potential Oocyte and Embryo Disposition Among Ovum Donors in an Egg Donation Program. Hum Reprod. 2006; 21(5): 1325-1327. doi:10.1093/humrep/dei468
78. Ross R, Lindheim SR, Olive DL, Pritts EA. Cornual gestation: a systematic literatre review and two case reports of a novel treatment regimen. J Minim Invasive Gynecol. 2006; 13(1): 74-78. doi: http://dx.doi.org/10.1016/j.jmig.2005.11.005
79. Olive DL, Lindheim SR, Pritts EA. Conservative Surgical Management of Uterine Myomas. Obstet Gynecol Clin North Am. 2006; 33(1): 115-124. doi: 10.1016/j.ogc.2005.12.012
80. Christianson MS, Barker MA, Schouweiler C, OliveDL, Lindheim SR. Comparison of Stimulation Characteristics Using Either Reconstituted Recombinant Gonadotropins (rFSH) Or Cartridge rFSH With A Pen Device In Donor Oocyte Cycles. Current Medical Research and Opinions. 2007; 23(5): 865-870.
81. Barker MA, Christianson MS. Schouweiler C, Evans M, Olive DL, Lindheim SR. Experience Using a Flexible Regimen of GnRH-antagonists and aStep-up of Additional Gonadotropins In Donor Oocyte Cycles. Current Medical Research and Opinion. 2007; 23(9): 2297-2302.
82. Zweifel J, Christianson MS, Jeagher A, Olive DL, Lindheim SR. Needs Assessment For Couples Donating To Stem Cell Research: A Call for Guidelines. Fertil Steril. 2007; 88(3): 560-564.
83. Christianson MS, Barker MA, Lindheim SR. Overcoming the Challenging Cervix: Techniques to Access the Uterine Cavity. J Low Genit Tract Dis. 2008; 12(1): 24-31. doi: 10.1097/lgt.0b013e318150676d
84. Spieldoch RL, Winter TC, Schoweiler C, Ansay S, Evans MD, Lindheim SR. Optimal catheter placement during sonohysterography: a randomized controlled trial comparing cervical to uterine placement. Obstet Gynecol. 2008; 111(1): 15-21. doi: 10.1097/01.AOG.0000295865.93719.3f
85. Wei A, Mijaal K, Christianson MS, Schoweiler C, Lindheim SR. Comparison of GnRH-antagonists and Flareup GnRH Agonists In Donor Oocyte Cycles Using The Donor As Her Own Control. J Reprod Med. 2008; 53: 147-160.
86. Berry E, Lindheim SR, Connor JP, et al. Sonohysterography and endometrial cancer: Incidence and Functional Viability of Disseminated Malignant Cells. Am J Obstet Gynecol. 2008; 199 (3): 240e1-240e8. doi: 10.1016/j.ajog.2008.03.042
87. Zweifel J, Biaggio B, Schoweiler C, Lindheim SR. Follow-up Assessment of Excluded Oocyte Donor Candidates. J Obstet Gynaecol Research. 2009; 35(2): 320-325. doi: 10.1111/j.1447-0756.2008.00942.x
88. Barker MA, Boehnlein L, Kovacs P, Lindheim SR. Predictive Value of Late Follicular Phase and Luteal Phase Endometrial Thickness and Pattern on Pregnancy Outcomes In Oocyte Donation Cycles. J Assist Reprod Genet. 2009; 26(5): 243-249.
89. Porat N, Boehnlein LM, Kang J, Barker MA, Kovacs P, Lindheim SR. Blastocyst embryo transfer is the primary determinant for improved outcomes in oocyte donation cycles. J Obstet Gynaecol Research. 2010; 36(2): 357-363. doi: 10.1111/j.1447-0756.2009.01135.x
90. Porat N, Boehnlein LM, Schouweiler CM, Kang J, Lindheim SR. Interim analysis of a randomized clinical trial comparing abdominal versus transvaginal ultrasound-guided embryo transfer. J Obstet Gynaecol Res. 2010; 36(2): 384-392. doi: 10.1111/j.1447-0756.2009.01148.x
91. Vrontikis A, Chang PL, Kovacs P, Lindheim SR. Antral follicle counts (AFC) predict ovarian response and pregnancy outcomes in oocyte donation cycles. J Assist Reprod Genet. 2010; 27(7): 383-389. doi: 10.1007/s10815-010-9421-8
92. Lindheim SR, Parat N, Jaeger AS. Survey report of gamete donors. and recipients. preferences regarding disclosure of third party reproduction outcomes and genetic risk information. J Obstet Gynaecol Res. 2011; 37(4): 292-299. doi: 10.1111/j.1447-0756.2010.01333.x
93. Wu DH, Reynolds K, Maxwell R, Lindheim SR, Aubuchon M, Thomas MA. Age does not influence the effect of embryo fragmentation on blastocyst development. Fertil Steril. 2011; 95(8): 2778-2780. doi: 10.1016/j.fertnstert.2011.05.024
94. Jaeger AS, Ross LS, Lindheim SR. Observed Discrepancies in Donors. Information Sharing and Oocyte-Embryo Management and Disposition Reported To Reproductive Health Professionals: A Call For Programmatic Improvement. J Bioethics Primary Research. 2012; 3(1): 23-32. doi: 10.1080/21507716.2011.639125
95. Ressler IB, Jaeger AS, Lindheim SR. Evolving ethical issues in third party reproduction: Local and global considerations. World l Med Genet. 2012; 2(1): 1-8. doi: 10.5496/wjmg.v2.i1.1
96. Ma F, Wu DH, Deng L, et al. Sialidases on Mammalian Sperm Mediate Deciduous Sialylation during Capacitation. J Biol Chem. 2012; 287(45): 38073-38079. doi: 10.1074/jbc.M112.380584
97. Ayensu-Coker L, Bauman D, Lindheim SR, Breech L. Fertility Preservation in Pediatric. Adolescent and Young Adult Female Cancer Patients. Pediatr Endocrinol. 2012; 10(1): 174-187.
98. Pakrashi T, Roessler IB, Sroga JM, DiPaola KB, Thomas MA, Lindheim SR. Hysteroscopic Enucluation For Type II Submucosal Uterine Leiyomyomata Using a TRUCLEARHysteroscopic Morcellator: Case Report and Review of The Literature. J Laparoendoscopic Adv SurgTech. 2013; l23(4); 378-382.
99. Roessler IB, Pakrashi T, Sroga JM, DiPaola KB, Thomas MA, Lindheim SR. Effects of Embryo Transfer Catheters on the Endometrial Surface Noted at Hysteroscopy. J Minim Invasive Gynecol. 2013; 20(3): 381-385. doi: 10.1016/j.jmig.2013.01.004
100. Ayensu-Coker L, Essig E, Lindheim SR. Ethical Quandaries In Gamete-Embryo Cryopreservation Related To Oncofertility. J Law Med Ethics. 2013; 41(3): 711-719. doi: 10.1111/jlme.12081
101. Guralp O, Sheridan SM, Harter J, et al. A new diagnostic test for endometrial cancer?: Cytology analysis of sonohysterography distension media. Int J Gynecol Cancer. 2013; 23(7): 1252-1257. doi: 10.1097/IGC.0b013e31829fe8f6
102. Whigham LD, Butz DE, Dashti H, et al. Metabolic Evidence of Diminshed Lipid Oxidation in Women With Polycystic Ovary Syndrome. Curr Metabolomics. 2014; 2(4): 269-278.
103. Martinez AM, Sroga JM, Ressler IB, Ayensu-Coker L, Thomas MA, Lindheim SR. Sexual Satisfaction Is Reduced in the Female Patient and Sexually Intimate Partners Following Cancer Therapy. Advances in Sexual Medicine. 2014; 4: 65-70.
104. Lindheim SR, Ayensu-Coker L, O Leary K, Coyne K, Sinn S, Jaeger AS. The Impact of Assisted Reproductionon Socio-Cultural Values and Social Norms. Advances in Anthropology. 2014; 4: 227-242. doi: 10.4236/aa.2014.44025
105. Lindheim SR, Ressler IB, Bessett D, et al. The road to fatherhood using assisted reproduction technology: decision making processes and experiences among gay male intended parents and gestational surrogates.Gynecol Obstet Res Open J. 2014; 1(1): 12-17. doi: 10.17140/GOROJ-1-104
106. Coyne K, Winter III TC, Maxwell R, Lindheim SR. Changing the algorithm in the evaluation of pelvic anatomy in the infertile patient: is hysterosalpingo contrast sonography with saline-air device the appropriate test for everyone?Gynecol Obstet Res Open J. 2016; 2(5): 126-128. doi: 10.17140/GOROJ-2-126
Professor Of Obstetrics and Gynecology
Department of Obstetrics and Gynecology
American University of Beirut- Medical Center
Dr. Karam is Clinical Professor of medicine at the American University of Beirut. Dr. Karam was born in Lebanon in 1946 and graduated with a medical degree from the American university of Beirut in 1967. After finishing his residency training in Obstetrics and Gynecology, he completed several post-doctoral fellowships at the Lahey Clinic Foundation in Boston, the University of California in Los Angeles and Harvard Medical School, before joining the Johns Hopkins Hospital faculty in 1973. He returned to the American University of Beirut in 1973 as the Director of the Johns Hopkins Program for International Education in Gynecology and Obstetrics and introduced endoscopic surgery to the Middle East.
Dr Karam was appointed and served as the Chairman of the Department of Obstetrics and Gynecology at the American University of Beirut from 1987 to 1999. During his term, he was also elected as the President of the Scientific Council of the Arab Board of Medical Specializations. He helped establish academic criteria for postgraduate medical education, and set the principles of accredited specializations.
Dr. Karam was appointed as minister of Health of Lebanon from 1998 to 2000 and diligently pursued an ambitious program for health care reform. He was instrumental in establishing the Inter- Ministerial Commission for Health Reforms and was elected President of the Arab Council of Ministers of Health. His notable achievements included the establishment of the universal health-care financing agency. He also fostered efforts for the implementation of universal health-care insurance coverage as well as a computerized database of medical records. Dr Karam was instrumental in the establishment of the Lebanese Order of nurses and a National Nursing Education Program. He dedicated several health care centers and applied laws that insured the autonomy of hospitals in their day-to-day operations. After securing a World Bank loan, he initiated an ambitious public hospital rehabilitation program and established a National Organ Donation Committee and a National Eye Bank.
Dr. Karam was elected to the Executive Board of the World Health Organization from 1999 to 2002 and was the chairman of Committee B of the World Health Assembly in 2000. As a WHO Board Member he chaired the WHOs Administration, Budget and Finance Committee in 2001 and served as its representative during the World Health Assembly in 2002. In 2002, the Republic of Lebanon and the councils of Arab Ministers of Health and Arab Ministers of Foreign Affairs- the League of Arab States, nominated Dr. Karam for the position of World Health Organization Director General to succeed Dr. Gro Harlem Bruntland.
Dr. Karam was appointed as Minister of Tourism and alternate Minister of Health from 2000 to 2003 and was elected to the Executive Board of the World Tourism Organization. Through his work in the Board he helped lead efforts for the stimulation of economic growth and job creation worlwide, providing incentive for environmental protection, heritage preservation and the promotion of peace and understanding among nations. In 2004, while serving as Minister of State, he was appointed as Minister of Culture.
Dr. Karam is married to Dr. Anne Marie Karam, an anesthesiologist at the American University of Beirut, and they have three children. Amer is an Associate Professor in the Department of Obstetrics and Gynecology, Director of Robotic surgery and Gynecologic Oncology at Stanford University USA. Dima, who has a bachelors degree in psychology and a masters degree in public health, is working as aResearcher at the Childrens Cancer Center of Lebanon. Choucrallah is an Industrial Engineer with a Masters in Business Administration and is working as a senior manager at Price Waterhouse Coopers in Dubai
His research interest include: Cardiothoracic Surgery.
HONORS AND AWARDS
• 2006, Recognition Award, Arab Board of Medical Specialization
• 2004, National Order of Republic of Hungary, Hungary
• 2004, National Order of the Cedars, Republic of Lebanon, Commander Rank, National Order of the Cedars
• 2002, Nominated as World Health Organization Director General, Republic of Lebanon and the councils of Arab Ministers of Health and Arab Ministers of Foreign Affairs- The League of Arab States
• 2001, Listed at Asian-American Whos Who, Whos Who
• 1993, National Order of the Cedars, Knight Rank, Republic of Lebanon
• 1978, The Sigma XI Club, American University of Beirut
• 1971, Physician Recognition award, American Medical Association
• 1962, Deans Honor List Bachelor of Science American University of Beirut American University of Beirut
• 1959, International College Penrose Award, International College
• 1959, International College Diploma with Distinction, International College
PEER REVIEWED JOURNAL PUBLICATIONS
1. Usta IM, Nassar AH, Awwad JT, Nakad TI, Khalil AM, Karam KS. Comparison Of The Perinatal Morbidity And Mortality Of The Presenting Twin And Its Co-Twin. Journal of Perinatology. 2002; 22(5): 391-396. doi: 10.1038/sj.jp.7210752
2. Abu-Musa A, Hannoun A, Khalil A, Masaad Z, Karam K. Artificial Endometrial Preparation For Oocyte Donation Using Synthetic Estrogen And Progestogen. Clinical and Experimental Obstetrics & Gynecology. 1998; 25(3): 83-85.
3. Hannoun AB, Khalil AM, Karam KS. Elective Shirodkar Procedure: Prognostic Factors and Postoperative Pregnancy Outcome. International Journal of Gynaecology and Obstetrics. 1998; 61(2): 187-188. doi: http://dx.doi.org/10.1016/S0020-7292(98)00037-X
4. Khalil AM, Azar GB, Hannoun AB, Sawaya JT, Abu-Musa AA, Karam KS. Reproductive Outcome Following Abdominal Metroplasty. International Journal of Gynaecology And Obstetrics. 1995; 49(2): 157-160. doi: http://dx.doi.org/10.1016/0020-7292(95)02370-R
5. Awwad JT, Khalil AM, Aswad NK, Suidan FJ, Karam KS. Labial Edema In Pregnancy. A Case Report. The Journal Of Reproductive Medicine. 1994; 39(11): 921-922.
6. Khalil AM, Azar GB, Karam KS. Conservative Management Of Pelvic Spleen. International Journal of Gynaecology and Obstetrics. 1994; 46(1): 65-66. doi: 10.1016/0020-7292(94)90313-1
7. Awwad JT, Azar GB, Karam KS, Nicolaides KH. Ear Length: A Potential Sonographic Marker For Down Syndrome. International Journal of Gynaecology and Obstetrics. 1994; 44(3): 233-238. doi: 10.1016/0020-7292(94)90172-4
8. Awwad JT, Azar GB, Seoud MA, Mroueh AM, Karam KS. High-Velocity Penetrating Wounds Of The Gravid Uterus: Review Of 16 Years Of Civil War. Obstetrics and Gynecology. 1994; 83(2): 259-264.
9. Awwad JT, Azar GB, Aouad At, Raad J, Karam KS. Postmortem Cesarean Section Following Maternal Blast Injury: Case Report. The Journal of Trauma. 1994; 36(2): 260-261. doi: 10.1016/0300-9572(94)90103-1
10. Usta IM, Aswad N, Karam KS. Unusual Fetal Survival After Extrauterine Fetoplacental Expulsion Into The Peritoneal Cavity. Journal of Maternal-Fetal Medicine. 1994; 3(4): 163-165. doi: 10.3109/14767059409017266
11. Awwad JT, Khalil AM, Matar MH, Karam KS. A Vaginal Cast. Journal of Obstetrics And Gynaecology. 1993; 13(3): 206-207.
12. Awwad JT, Azar GB, Aswad NK, Suidan FJ, Karam KS. Uterine Rupture in Pregnancy Caused By Blast Injury With Fetal Survival. Journal of Obstetrics and Gynaecology. 1993; 13(6).
13. Awwad JT, Nahhas De, Karam KS. Femur Fracture During Cesarean Breech Delivery. International Journal of Gynaecology and Obstetrics. 1993; 43(3): 324-326. doi: 10.1016/0020-7292(93)90524-Z
14. Usta IM, Awwad JT, Usta JA, Makarem MM, Karam KS. Imperforate Hymen: Report of An Unusual Familial Occurrence. Obstetrics and Gynecology. 1993; 82, 4(2 Suppl): 655-656. doi: 10.1016/0020-7292(94)90271-2
15. Baraka AS, Hanna MT, Jabbour Si, et al. Preoxygenation Of Pregnant And Nonpregnant Women In The Head-Up Versus Supine Position. Anesthesia and Analgesia. 1992; 75(5): 757-759.
16. Baraka A, Jabbour S, Tabboush Z, Sibai A, Bijjani A, Karam K. Onset Of Vecuronium Neuromuscular Block Is More Rapid In Patients Undergoing Caesarean Section. Canadian Journal of Anaesthesia. 1992; 39(2): 135-138. doi: 10.1007/BF03008643
17. Awad JT, Azar GB, Karam KS. Puerperal Uterine Inversion. The Lebanese Medical Journal. 1992; 40(3): 169-172.
18. Karam K, Sayegh R, Saadeh G, Saba M. Gonadotropin Secreting Pituitary Microadenoma. The Lebanese Medical Journal. 1992; 40(1): 31-35.
19. Homsi R, Karam K. Unilateral Streak Ovary (Slotnick-Goldfarb Syndrome): A Case Report And Review Of The Literature. Adolescent and Pediatric Gynecology. 1992; (5): 1, 43-45.
20. Hannoun A, Khalil A, Karam K. Uterine Unification Procedures: Post-Operative Obstetrical Outcome. International Journal of Gynaecology and Obstetrics. 1989; 30(2): 161-164. doi: 10.1016/0020-7292(89)90311-1
21. Ataya KM, Mudawwar F, Allam C, Karam K. Hypergonadotropism with Pregnancy. American Journal of Obstetrics and Gynecology. 1983; 146(3): 341-343.
22. Karam K. Prevention Of Infertility. The Lebanese Medical Journal. 1980; 31(1): 25-30.
23. Karam KS, Burnett LS, King TM. Oxytocin Augmentation of Intra-Amniotic Saline For Termination Of Pregnancy. The Lebanese Medical Journal. 1980; 31(3): 235-243.
24. Karam K, Hajj S. Hyperthecosis Syndrome. Clinical, Endocrinologic and Histologic Findings. Acta Obstetricia Et Gynecologica Scandinavica. 1979; 58(1): 73-79. doi: 10.3109/00016347909154919
25. Karam K, Mroueh A. Ovarian Biopsy In The Evaluation Of Amenorrhea. Acta Obstetricia Et Gynecologica Scandinavica. 1978; 57(4): 301-311. doi: 10.3109/00016347809154022
26. Karam KS, Salti I, Hajj SN. Congenital Absence of the Uterus. Clinicopathologic And Endocrine Findings. Obstetrics and Gynecology. 1977; 50(5): 531-535.
27. Karam KS, Hajj SN. Mesenteric Hematoma-Meckels Diverticulum: A Rare Laparoscopic Complication. Fertility and Sterility. 1977; 28(9): 1003-1005.
28. Thompson LE, Karam KS, Taymor Ml. Positive Feedback Effects Of Estrogen In Amenorrheic Women. American Journal of Obstetrics and Gynecology. 1974; 118(6): 788-792.
29. Karam KS, Taymor Ml, Berger MJ. Estrogen Monitoring and the Prevention Of Ovarian Overstimulation During Gonadotropin Therapy. American Journal of Obstetrics and Gynecology. 1973; 115(7): 972-977.
30. Nudemberg F, Kothari M, Karam K, Taymor Ml. Effects Of The "pill-A-Month" On The Hypothalamic-Pituitary-Ovarian Axis. Fertility and Sterility. 1973; 24(3): 185-190.
31. Berger Mj, Taymor Ml, Karam K, Nudemberg F. The Relative Roles Of Exogenous And Endogenous Follicle-Stimulating Hormone (Fsh) And Luteinizing Hormone (Lh) In Human Follicular Maturation And Ovulation Induction. Fertility and Sterility. 1972; 23(11): 783-790.
32. Taymor Ml, Berger MJ, Thompson LE, Karam KS. Hormonal Factors In Human Ovulation. American Journal of Obstetrics and Gynecology. 1972; 114(4): 445-453.
33. Karam KS, Hajj SN. Current status of birth control pills. Lebanese Medical Journal. 1979; 30: 11-22.
34. Khudr A, Dudin Alexander P, et al. Prenatal Diagnosis In Lebanon. Lebanese Medical Journal. 1985; 35: 115-124.
35. Karam KS. Laparoscopy. Lebanese Medical Journal. 1975; 28: 485-503.
Department of Obstetrics and Gynecology
Wayne State University School of Medicine
540 E Canfield St
Detroit, MI 48201, USA
Dr. Saed is currently an Associate Professor in the Department of Obstetrics and Gynecology at Wayne State University School of Medicine in Detroit, Michigan. He is an internationally renowned clinical and translational investigator, who is recognized for many scientific contributions within the fields of Reproductive Endocrinology and Infertility and Gynecologic Oncology.
Dr. Saed has over 20 years of experience in the pathogenesis of tissue fibrosis and cancer. He is extensively published in this area, particularly in the implications of extracellular matrix molecules, growth factors, free radicals, apoptosis and proliferation in tissue scarring and cancer.
His research interests includes: Molecular mechanisms investigating the role of oxidative stress in the pathogenesis of ovarian cancer and the Development of Chemoresistance. Comparison of the effects of oxidative stress on the pathogenesis of a Malignant overgrowth versus a benign overgrowth, such as postoperative adhesions are also a major focus of his research.
MAJOR PROFESSIONAL SOCIETIES
• American Association of Cancer Research
• American Association of University Professors
• American Chemical Society
• American Federation of Clinical Research
• American Society for Reproductive Medicine
• National Arab American Medical Association
• Society for Gynecologic Investigation
• (1984-1998) Medical Research Council of the United Kingdom
• (1985-1986) National Research Council of the United Kingdom
• (1996-1997) Outstanding Professor of the Year Award nominee by the Golden Key National Society, Oakland University Chapter, Rochester, MI
• (1998) Award Paper, Society of Reproductive Surgeons
• (2000) Finalist Paper, Society of Reproductive Endocrinologists
• (2000) Award Paper, Society of Reproductive Surgeons
• (2003) Finalist Paper, European Society of Human Reproduction
• (2003) Finalist Paper, Society of Reproductive Endocrinologists
• (2005) Finalist Paper, American Society for Reproductive Medicine
• (2006) Finalist Paper, American Society for Reproductive Medicine
• (2009) Nominated for President’s Award for Excellence in Teaching, Wayne State University School of Medicine, Detroit, MI
• (2011) American Society for Reproductive Medicine (ASRM) Star Award (awarded to reproductive health professionals who have presented at at least nine of the last ten ASRM annual meetings)
• (2013) American Society for Reproductive Medicine (ASRM) Star Award (awarded to reproductive health professionals who have presented at at least nine of the last ten ASRM annual meetings)
1. El-Thaher TS, Saed GM, Bailey GS. A simple and rapid purification of kallikrein from rat submandibular gland. Biochemical and Biophsical Acta. 1990; 1034(2): 157-161.
2. Saed GM, Carretero OA, MacDonald R, Scicli AG. Kallikrein messenger RNA in rat arteries and veins. Circulation Research. 1990; 67(2): 510-516.
3. Saed GM, Beierwaltes WH, Carretero OA, Scicli AG. Submandibular enzymatic vasoconstrictor messenger RNA in rat kidney. Hypertension. 1992; 19(2): 11262-11267.
4. el-Thaher TS, Saed GM, Bailey GS. Characterization of kallikrein isolated from rat submandibular glands by a simple and rapid purification procedure. Agents and Action Supplement . 1992; 38(1): 98-105.
5. Nolly H, Saed GM, Scicli AG, Carretero OA, Scicli AG. The Kallikrein-Kinin system in cardiac tissue. Agents and Actions Supplement. 1992; 38(3): 62-72.
6. Nolly H, Saed G, Carretero O, Scicli AG. Adrenal kallikrein. Hypertension. 1993; 21 (6): 911-915.
7. Valdés G, Corthorn J, Scicli AG, et al. Uterine kallikrein in the early pregnant rat. Biology of Reproduction. 1993; 49(4): 802-808.
8. Joseph R, Tsang W, Han E, Saed GM. Neuoronal beta-amyloid precursor protein gene expression: Regulation by aurintricarboxylic acid. Brain Research. 1993; 625(2): 244-255.
9. Fivenson DR, Saed GM, Beck ER, Dunstan RW, Moore PF. T-cell receptor gene rearrangement in canine mycosis fungoides: Further support for a canine model of cutaneous T-cell lymphoma. Journal of Investigative Dermatology. 1994; 102(2): 227-230.
10. Saed GM, Fivenson DP, Nickoloff BJ. Mycosis fungoides exhibits a Th1 type cell-mediated cytokine profile whereas Sezary syndrome expresses a Th2 type profile. Journal of Investigative Dermatology. 1994; 103(1): 29-33. doi: 10.1111/1523-1747.ep12388985
11. Saed GM, Fivenson DP. Quantitation of interferon-gamma mRNA levels in psoralen/UVA-treated HUT-78 cells by competitive PCR. Biochemical and Biophysical Research Communication. , 1994; 203(2): 935-942. 10.1006/bbrc.1994.2272
12. Dillon WI, Saed GM, Fivenson DP. Borrellia burgdorferi DNA is undetectable by polymerase chain reaction in skin lesions of morphea, scleroderma and lichen sclerosus et atrophicus of patients from North America. Journal of the American Academy of Dermatology. 1995; 33(4): 617-620.
13. Fivenson DP, Schaffer J, Saed GM, Beck ER, Wood GS. Absence of human T-cell lymphotropic virus genomic determinants in canine mycosis fungoides. Archives of Dermatology. 1996; 132(1): 841-842,
14. Stein L, Saed GM, Fivenson DP. T-cell cytokine network in cutaneous lupus erythematosus. Journal of the American Academy of Dermatology. 1997; 36 (2(1)):191-196.
15. Ricketts CH, Martin L, Faria DT, Saed GM, Fivenson DP. Cytokine mRNA changes during the treatment of hypertrophic scars with silicone and non-silicone gel dressings. Dermatology Surgery. 1996; a. 22(11): 955-964.
16. Ladin DA, Hou Z, Patel D, et al. p53 and apoptosis alterations in keloids and keloid fibroblasts. Wound Repair and Regeneration. 1998; 6(1): 28-37.
17. Saed G, Ladin D, Olsen J, Han X, Hou Z, Fivenson D. Analysis of p53 gene mutations in keloids using polymerase chain reaction-based single-strand conformational polymorphism and DNA sequencing. Archives of Dermatology . 1998; 134(8): 963-967.
18. Saed GM, Zhang W, Chegini N, Holmdhal L, Diamond MP. Alteration of type I and III collagen expression in human peritoneal mesothelial cells in response to hypoxia and transforming growth factor-beta1. Wound Repair and Regeneration. 1999; 7(6): 504-510.
19. Wittenberg GP, Fabian BG, Bogomilsky JL, et al. Prospective, single-blind, randomized, controlled study to assess the efficacy of the 585-nm flashlamp-pumped pulsed-dye laser and silicone gel sheeting in hypertrophic scar treatment. Archives of Dermatology. 1999; 135(9): 1049-1055. doi: 10.1001/archderm.135.9.1049
20. Saed GM, Zhang W, Chegini N, Holmdahl L, Diamond MP. Transforming growth factor beta isoforms production by human peritoneal mesothelial cells after exposure to hypoxia. American Journal of Reproductive Immunology. 2000; 43(5): 285-291.
21. Saed GM, Zhang W, Diamond MP. Effect of hypoxia on the stimulatory effect of TGF-beta 1 on MMP-2 amd MMP-9 activities in mouse fibroblasts. Journal of the Society of Gynecologic Investigation. 2000; 7(6): 348-354.
22. Saed GM, Zhang W, Diamond MP. Molecular characterization of fibroblasts isolated from human peritoneum and adhesions. Fertility and Sterility. 2001; 75(4): 763-768. doi: 10.1177/107155760000700606
23. Chegini N, Kotseos K, Ma C, et al. Peritoneal Healing and Adhesion MultiUniversity Study Group. Differential expression of integrin alphav and beta3 in serosal tissues of human intraperitoneal organs and adhesion. Fertility and Sterility. 2001; 75(4): 791-796.
24. Chegini N, Kotseos K, Bennett B, et al. Peritoneal Healing and Adhesion MultiUniversity Study Group. Matrix metalloproteinase (MMP-1) and tissue inhibitor of MMP in peritoneal fluids and sera and correlation with peritoneal adhesions. Fertility and Sterility. , 2001; 76(6): 1207-1211.
25. Chegini N, Kotseos K, Zhao Y, et al. Peritoneal Healing and Adhesion Multi-University Study (PHAMUS) Group. Expression of matrix metalloproteinase (MMP-1) and tissue inhibitor of MMP in serosal tissue of intraperitoneal organs and adhesions. Fertility and Sterility. 2001; 76(6): 1212-1219.
26. Svinarich DM, Zaher FM, Holmdahl L, et al. Peritoneal Healing and Adhesion Multi-University Study (PHAMUS) Group. Adhesion development and the expression of endothelial nitric oxide synthase. Infectious Diseases in Obstetrics and Gynecology. , 2001; 9(2): 113-116.
27. Chegini N, Kotseos K, Zhao Y, et al. Peritoneal Healing and Adhesion Multi-University Study (PHAMUS) Group. Differential expression of TGF-beta1 and TGF-beta3 in serosal tissues of human intraperitoneal organs and peritoneal adhesions. Journal of Molecular Human Reproduction. 16(6):1291-1300, 2001.
28. Saed GM, Diamond MP. Apoptosis and proliferation of human peritoneal fibroblasts in response to hypoxia. Fertility and Sterility. 78(1): 137-143.
29. Saed GM, Diamond MP. Hypoxia-induced irreversible up-regulation of type I collagen and transforming growth factor-beta1 in human peritoneal fibroblasts. Fertility and Sterility. 2002; 78(1):144-147.
30. Saed GM, Collins KL, Diamond MP. Transforming growth factors beta1, beta2, and beta3 and their receptors are differentially expressed in human peritoneal fibroblasts in response to hypoxia. American Journal of Reproductive Immunology. 2002; 48(6):387-393.
31. Rout UK, Saed GM, Diamond MP. Transforming growth factor-beta1 modulates expression of adhesion and cytoskeletal proteins in human peritoneal fibroblasts. Fertility and Sterility. 2002; 78(1):154-161. doi: 10.1016/S0015-0282(02)03176-X
32. Munkarah AR, Morris RT, Baumann P, et al. Effects of prostaglandin E(2) on proliferation and apoptosis of epithelial ovarian cancer cells. Journal of the Society for Gynecologic Investigation. , 2002; 9(3):168-173.
33. Diamond MP, Elhammady E, Wang R, Saed G. Metabolic regulation of collagen I in fibroblasts isolated from normal peritoneum and adhesions by dichloroacetic acid. American Journal of Obstetrics and Gynecology. 2002; 187(6):1456-1460;
34. Freeman ML, Saed GM, Diamond MP. Hormone-independent ovarian influence on adhesion development. Fertility and Sterility. 2002; 78(2): 340-346, 2002.
35. Chegini N, Zhao Y, Kotseos K, et al. Peritoneal Healing and Adhesion MultiUniversity Study Group. Differential expression of matrix metalloproteinase and tissue inhibitor of MMP in tissue of serosal intraperitoneal organs and adhesions. British Journal of Obstetrics and Gynecology . 2002; 109(9): 1041-1049.
36. Munkarah AR, Genhai Z, Morris R, et al. Inhibition of paclitaxel-induced apoptosis by the specific COX-2 inhibitor, NS398, in epithelial ovarian cancer cells. Gynecologic Oncology. 2003; 88(3): 429-433.
37. Saed GM, Diamond MP. Effect of glucose on the expression of type I collagen and transforming growth factor-beta1 in cultured human peritoneal fibroblasts. Fertility and Sterility. 2003; 79(1): 158-163.
38. Saed GM, Diamond MP. Modulation of the expression of tissue plasminogen activator and its inhibitor by hypoxia in human peritoneal and adhesion fibroblasts. Fertility and Sterility. 2003; 79(1): 164-168.
39. Diamond MP, Elhammady E, Wang R, Saed GM. Regulation of transforming growth factor-beta, type III collagen, and fibronectin by dichloroacetic acid in human fibroblasts from normal peritoneum and adhesions. Fertility and Sterility. 2003; 79(5): 1161-1167.
40. Saed GM, Munkarah AR, Diamond MP. Cyclooxygenase-2 is expressed in human fibroblasts isolated from intraperitoneal adhesions but not from normal peritoneal tissues. Fertility and Sterility. 2003; 79(6): 1404-1408,.
41. Freeman ML, Saed GM, Elhammady EF, Diamond MP. Expression of transforming growth factor beta isoform mRNA in injured peritoneum that healed with adhesions and without adhesions and in uninjured peritoneum. Fertility and Sterility. 2003; 80(2): 708-713.
42. Gago LA, Saed GM, Chauhan S, Elhammady EF, Diamond MP. Seprafilm (modified hyaluronic acid and carboxymethylcellulose) acts as a physical barrier. Fertility and Sterility. 2003; 80(3): 612-616.
43. Gago LA, Saed GM, Wang RX, Kruger M, Diamond MP. Effects of oxidized regenerated cellulose on the expression of extracellular matrix and transforming growth factor-beta1 in human peritoneal fibroblasts and mesothelial cells. American Journal of Obstetrics and Gynecology. 189(6): 1620-1625.
44. Galijasevic S, Saed GM, Diamond MP, Abu-Soud HM. Myeloperoxidase up-regulates the catalytic activity of inducible nitric oxide synthase by preventing the nitric oxide feedback inhibition. Proceedings of the National Academy of Sciences. 2003; 100(25): 14766-14771.
45. Saed GM, Diamond MP. Effect of glucose on the expression of type I collagen and transforming growth factor-beta1 in cultured human peritoneal fibroblasts. Fertility and Sterility . 2003; 79(1):158-163.
46. Diamond MP, Elhammady E, Wang R, Saed G. Regulation of matrix metalloproteinase-1 and tissue inhibitor of matrix metalloproteinase-1 by dichloroacetic acid in human fibroblasts from normal peritoneum and adhesions. Fertility and Sterility. 2004; 81(1): 185-190.
47. Diamond MP, Kruger M, Saed GM. Effect of Tisseel on expression of tissue plasminogen activator and plasminogen activator inhibitor-1. Fertility and Sterility. 2004; 81(6):1657-1664.
48. Zhu G, Saed GM, Deppe G, Diamond MP, Munkarah AR. Hypoxia up-regulates the effects of prostaglandin E2 on tumor angiogenesis in ovarian cancer cells. Gynecologic Oncology . 2004; 94(2): 422-426. 10.1016/j.ygyno.2004.05.010
49. Galijasevic S, Saed GM, Diamond MP, Abu-Soud HM. High dissociation rate constant of ferrous-dioxy complex linked to the catalase-like activity in lactoperoxidase. Journal of Biological Chemistry. 2004; 279(38): 39465-39470.
50. Diamond MP, El-Hammady E, Wang R, Kruger M, Saed G. Regulation of expression of tissue plasminogen activator and plasminogen activator inhibitor-1 by dichloroacetic acid in human fibroblasts from normal peritoneum and adhesions. American Journal of Obstetrics and Gynecology . 2004; 190(4): 926-934.
51. Saed GM, Diamond MP. Molecular characterization of postoperative adhesions: the adhesion phenotype. Journal of the American Association for Gynecologic Laparoscopists. 2004; 11(3):307-314.
52. Saed GM, Kruger M, Diamond MP. Expression of transforming growth factor beta and extracellular matrix by human peritoneal mesothelial cells and by fibroblasts from normal peritoneum and adhesions: effect of Tisseel. Wound Repair and Regeneration. 2004; 12(5):557-564.
53. Buhimschi IA, Jabr M, Buhimschi CS, Petkova AP, Weiner CP, Saed GM. The novel antimicrobial peptide beta3-defensin is produced by the amnion: a possible role of the fetal membranes in innate immunity of the amniotic cavity. American Journal of Obstetrics and Gynecology. 2004; 191(5):1678-1687.
54. Saed GM, Abu-Soud HM, Diamond MP. Role of nitric oxide in apoptosis of human peritoneal and adhesion fibroblasts after hypoxia. Fertility and Sterility . 2004; 82 Suppl 3: 1198-1205, 2004.
55. Saed GM, Diamond MP. Differential expression of alpha smooth muscle cell actin in human fibroblasts isolated from intraperitoneal adhesions and normal peritoneal tissues. Fertility and Sterility. 2004; 82 Suppl 3: 1188-1192, 2004.
56. Saed GM, Galijasevic S, Diamond MP, Abu-Soud HM. Measurement of oxygen and nitric oxide levels in vitro and in vivo: relationship to postoperative adhesions. Fertility and Sterility. 2005; 84(1): 235-238, 2005.
57. Saed GM, Munkarah AR, Abu-Soud HM, Diamond MP. Hypoxia upregulates cyclooxygenase- 2 and prostaglandin E(2) levels in human peritoneal fibroblasts. Fertility and Sterility. 2005; 83 Suppl 1: 1216-1219, 2005.
58. Diamond MP, Elhammady E, Munkarah A, Bieber EJ, Saed GM. Modulation of the expression of vascular endothelial growth factor in human fibroblasts. Fertility and Sterility . 2005; 83(2): 405-409, 2005.
59. Rout UK, Saed GM, Diamond MP. Expression pattern and regulation of genes differ between fibroblasts of adhesion and normal human peritoneum. Reproductive Biology and Endocrinology. 3: 1.
60. Saed GM, Kruger ML, Diamond MP. Enhanced matrix metalloproteinase expression by Tisseel in mesothelial cells, normal peritoneal fibroblasts, and adhesion fibroblasts. European Journal of Plastic Surgery. 28(7):472-479, 2006.
61. Gago, LA, Saed G, Elhammady E, Diamond MP. Effect of oxidized regenerated cellulose (Interceed) on the expression of tissue plasminogen activator and plasminogen activator inhibitor-1 in human peritoneal fibroblasts and mesothelial cells. Fertility and Sterility. 86(4 Suppl):1223-1227, 2006.
62. insulin and insulin-like growth factor-I receptors in human normal peritoneal and adhesion fibroblasts. Fertility and Sterility. 2006; 86(4 Suppl):1217-1222.
63. Alpay Z, Saed GM, Diamond MP. Female infertility and free radicals: Potential role in adhesions and endometriosis. Journal for the Society for Gynecologic Investigation. 2006; 13(6): 390-398.
64. Malone JM, Saed GM, Diamond MP, Sokol RJ, Munkarah AR. The effects of the inhibition of inducible nitric oxide synthase on angiogenesis of epithelial ovarian cancer. American Journal of Obstetrics and Gynecology. 2006; 194(4): 1110-1116.
65. Alpay Z, Ozgönenel MS, Savasan S, Buck S, Saed GM, Diamond MP. Possible role of natural immune response against altered fibroblasts in the development of post-operative adhesions. American Journal of Reproductive Immunology . 2006; 55(6):420-427.
66. Saed GM, Diamond MP. Effects of interferon-gamma reverse hypoxia-stimulated extracellular matrix expression in human peritoneal and adhesion fibroblasts. Fertility and Sterility. 2006; 85 Suppl 1: 1300-1305.
67. Saed GM, Zhao M, Diamond MP, Abu-Soud HM. Regulation of inducible nitric oxide synthase in post-operative adhesions. Human Reproduction. 2006; 21(6):1605-1611.
68. Galijasevic S, Saed GM, Hazen SL, Abu-Soud HM. Myeloperoxidase metabolizes thiocyanate in a reaction driven by nitric oxide. Biochemistry. 2006; 45(4): 1255-1262. doi: 10.1021/bi051438k
69. Munkarah AR, Ali-Fehmi R, Jiang JZ, Elhammady E, Malone JM Jr, Saed GM. The effects of combining docetaxel and cyclooxygenase-2 inhibitors on proliferation and apoptosis in epithelial ovarian cancer. Anticancer Drugs. 2007; 18(8): 889-896.
70. Victory R, Saed GM, Diamond MP. Antiadhesion effects of docosahexaenoic acid on normal human peritoneal and adhesion fibroblasts. Fertility and Sterility. 2007; 88(6): 1657-1662.
71. Diamond MP, Saed G. Modulation of the expression of peroxisome proliferators-activated receptors in human fibroblasts. Fertility and Sterility. 2007; 87(3): 706-709.
72. Alpay Z, Ozgönenel M, Savasan S, Buck S, Saed GM, Diamond MP. Altered in vitro immune response to hypoxia-treated normal peritoneal fibroblasts. Fertility and Sterility. 2007; 87(2): 426-429. doi: 10.1016/j.fertnstert.2006.07.1495
73. Pansare V, Munkarah AR, Schimp V, et al. Increased expression of hypoxia-inducible factor 1-alpha in type I and type II endometrial carcinomas. Modern Pathology. 2007; 20(1): 35-43.
74. Saed GM. Immunohistochemical staining of cyclooxygenases with monoclonal antibodies. Methods in Molecular Biology. 2008; 477: 219-228.
75. Saed GM, Al-Hendy A, Salama SA, Diamond MP. Adenovirus-mediated expression of cyclooxygenase-2 antisense reverses abnormal genetic profile of human adhesion fibroblasts. Fertility and Sterility. 2008; 89(5 Suppl): 1455-1460
76. Diamond MP, Wirth JJ, Saed GM. PCBs enhance collagen I expression from human peritoneal fibroblasts. Fertility and Sterility. 2008; 90(4): 1372-1375. doi: 10.1016/j.fertnstert.2007.07.1380
77. Alpay Z, Saed GM, Diamond MP. Postoperative adhesions: from formation to prevention. Seminars in Reproductive Medicine. 2008; 26(4): 313-321. doi: 10.1055/s-0028-1082389
78. Imudia AN, Kumar S, Saed GM, Diamond MP. Pathogenesis of intra-abdominal and pelvic adhesion development. Seminars in Reproductive Medicine. 2008; 26(4): 289-297.
79. Detti L, Saed GM, Jiang ZL, Kruger ML, Diamond MP. The effect of estradiol on the expression of estrogen, progesterone, androgen, and prolactin receptors in human peritoneal fibroblasts. Journal of Assisted Reproduction and Genetics. 2008; 25(6): 245-250. doi: 10.1007/s10815-008-9230-5
80. Fletcher NM, Jiang ZL, Diamond MP, Abu-Soud HM, Saed GM. Hypoxia-generated superoxide induces the development of the adhesion phenotype. Free Radical Biology and Medicine. 2008; 45(4): 530-536. doi: 10.1016/j.freeradbiomed.2008.05.002
81. Jiang ZL, Zhu X, Diamond MP, Abu-Soud HM, Saed GM. Nitric oxide synthase isoforms expression in fibroblasts isolated from human normal peritoneum and adhesion tissues. Fertility and Sterility. 2008; 90(3): 769-764.
82. Saed GM, Jiang Z, Fletcher NM, Diamond MP. Modulation of the BCL-2/BAX ratio by interferon-gamma and hypoxia in human peritoneal and adhesion fibroblasts. Fertility and Sterility . 2008; 90(5): 1925-1930.
83. Saed GM, Jiang Z, Diamond MP, Abu-Soud HM. The role of myeloperoxidase in the pathogenesis of postoperative adhesions. Wound Repair and Regeneration. 2009; 17(4): 531-539 .
84. Shavell VI, Saed GM, Diamond MP. Review: Cellular metabolism: contribution to postoperative adhesion development. Reproductive Sciences. 2009; 16(7): 627-634. doi: 10.1177/1933719109332826
85. Jiang ZL, Fletcher NM, Diamond MP, Abu-Soud HM, Saed GM. Hypoxia regulates iNOS expression in human normal peritoneal and adhesion fibroblasts through nuclear factor kappa B activation mechanism. Fertility and Sterility. 2009; 91(2): 616-621.
86. Jiang ZL, Fletcher NM, Diamond MP, Abu-Soud HM, Saed GM. S-nitrosylation of caspase-3 in the mechanism by which adhesion fibroblasts manifest lower apoptosis. Wound Repair and Regeneration. 2009; 17(2): 224-229. doi: 10.1111/j.1524-475X.2009.00459.x
87. Awongua A, Diamond M, Saed G. Laparoscopy in gynecologic surgery: adhesion development, prevention and use of adjunctive therapies. Clinical Obstetrics and Gynecology . 2009; 52(3): 412-422. doi: 10.1097/GRF.0b013e3181b0c121
88. Saed GM, Ali-Fehmi R, Jiang ZL, et al. Myeloperoxidase serves as a redox switch that regulates apoptosis in epithelial ovarian cancer. Gynecologic Oncology. 2010; 116(2): 276-281.
89. Saed GM, Jiang ZL, Fletcher NM, Al Arab A, Diamond MP, Abu-Soud HM. Exposure to polychlorinated biphenyls enchances lipid peroxidation in human normal peritoneal and adhesion fibroblasts: a potential role for myeloperoxidase. Free Radical Biology and Medicine. 2010; 48(6): 845-850.
90. Pennathur S, Maitra D, Byun J, et al. Potent antioxidative activity of lycopene: A potential role in scavenging hypochlorous acid. Free Radical Biology and Medicine. 2010; 49(2): 205-213. doi: 10.1016/j.freeradbiomed.2010.04.003
91. Bryant CS, Munkarah AR, Kumar S, et al. Reduction of hypoxia-induced angiogenesis in ovarian cancer cells by inhibition of HIF-1 alpha gene expression. Archives of Gynecology and Obstetrics. 2010; 282(6): 677-683.
92. Ali-Fehmi R, Semaan A, Sethi S, et al. Molecular typing of epithelial ovarian carcinomas using inflammatory markers. Cancer. 2011; 117(2): 301-309. doi: 10.1002/cncr.25588
93. Fletcher NM, Jiang Z, Ali-Fehmi R, et al. Myeloperoxidase and free iron levels: potential biomarkers for early detection and prognosis of ovarian cancer. Cancer Biomarkers. 2011; 10(6): 267-275.
94. Detti L, Saed GM, Fletcher NM, Kruger ML, Brossoit M, Diamond MP. Endometrial morphology and modulation of hormone receptors during ovarian stimulation for assisted reproductive technology cycles. Fertility and Sterility . 2011; 95(3): 1037-1041. doi: 10.1016/j.fertnstert.2010.12.025
95. Jiang Z, Fletcher NM, Ali-Fehmi R, et al. Modulation of redox signaling promotes apoptosis in epithelial ovarian cancer cells. Gynecologic Oncology. 2011; 122(2): 418-423. doi: 10.1016/j.ygyno.2011.04.051
96. Meng Q, Sun W, Jiang J, Fletcher NM, Diamond MP, Saed GM. Identification of common mechanisms between endometriosis and ovarian cancer. Journal of Assisted Reproduction and Genetics. 2011; 28(10): 917-923.
97. Saed GM, Fletcher NM, Jiang ZL, Abu-Soud HM, Diamond MP. Dichloroacetate induces apoptosis of epithelial ovarian cancer cells through a mechanism involving modulation of oxidative stress. Reproductive Sciences. 18(12): 1253-1261. doi: 10.1177/1933719111411731
98. Maitra D, Byun J, Andreana PR, Abdulhamid I, Saed GM, Diamond MP, Pennathur S, Abu-Soud HM. Mechanism of hypochlorous acid-mediated heme destruction and free iron release. Free Radical Biology and Medicine. 2011; 51(2): 364-373.
99. Maitra D, Byun J, Andreana PR, et al. Reaction of hemoglobin with HOCl: mechanism of heme destruction and free iron release. Free Radical Biology and Medicine. 2011; 51(2): 374-386. doi: 10.1016/j.freeradbiomed.2011.04.011
100. Awonuga AO, Fletcher NM, Saed GM, Diamond MP. Postoperative adhesion development following cesarean and open intra-abdominal gynecological operations: a review. Reproductive Sciences. 2011; 18(12): 1166-1185.
101. White JC, Jiang ZL, Diamond MP, Saed GM. Macrophages induce the adhesion phenotype in normal peritoneal fibroblasts. Fertility and Sterility. 2011; 96(3): 758-763.e3.
102. Souza CE, Maitra D, Saed GM, et al. Hypochlorous acid-induced heme degradation from lactoperoxidase as a novel mechanism of free iron release and tissue injury in inflammatory diseases. PLoS One. 2011; 6(11): e27641. doi: 10.1371/journal.pone.0027641
103. Abu-Soud HM, Maitra D, Byun J, et al. The reaction of HOCl and cyanocobalamin: corrin destruction and the liberation of cyanogens chloride. Free Radical Biology and Medicine. 2012; 52(3): 616-625. doi: 10.1016/j.freeradbiomed.2011.10.496
104. Fletcher NM, Jiang Z, Ali-Fehmi R, et al. Myeloperoxidase and free iron levels: potential biomarkers for early detection and prognosis of ovarian cancer. Cancer Biomarkers. 2012; 10(6): 267-275. doi: 10.3233/CBM-2012-025
105. Shavell VI, Fletcher NM, Jiang ZL, Saed GM, Diamond MP. Uncoupling oxidative phosphorylation with 2,4-dinitrophenol promotes development of the adhesion phenotype. Fertility and Sterility. 2012; 97(3): 729-733. doi: 10.1016/j.fertnstert.2011.12.009
106. Ambler DR, Golden AM, Gell JS, Saed GM, Carey DJ, Diamond MP. Microarray expression profiling in adhesion and normal peritoneal tissues. Fertility and Sterility . 2012; 97(5):1158-1164.e1-4.
107. Maitra D, Abdeulhamid I, Diamond MP, Saed GM, Abu-Soud HM. Melatonin attenuates hypochlorous acid-mediated heme destruction, free iron release, and protein aggregation in hemoglobin. Journal of Pineal Research. 2012; 53(2): 198-205. doi: 10.1111/j.1600-079X.2012.00988.x
108. Ambler DR, Fletcher NM, Diamond MP, Saed GM. Effects of hypoxia on the expression of inflammatory markers IL-6 and TNF-a in human normal peritoneal and adhesion fibroblasts. Systems Biology and Reproductive Medicine. 2012; 58(6): 324-329. doi: 10.3109/19396368.2012.713439
109. Abu-Soud HM, Maitra D, Byun J, et al. The reaction of HOCl and cyanocobalamin: corrin destruction and the liberation of cyanogen chloride. Free Radical and Biological Medicine. 2012; 52(3):616-625.
110. Maitra D, Shaeib F, Abdulhamid I, et al. Myeloperoxidase acts as a source of free iron during steady-state catalysis by a feedback inhibitory pathway. Free Radical and Biological Medicine. 2013; 63:90-98.
111. Banerjee J, Shaeib F, Maitra D, et al. Peroxynitrite affects the cumulus cell defense of metaphase II mouse oocytes leading to disruption of the spindle structure in vitro. Fertility and Sterility. 2013; 100(2):578-584.e1.
112. Detti L, Uhlmann RA, Fletcher NM, Diamond MP, Saed GM. Endometrial signaling pathways during ovarian stimulation for assisted reproduction technology. Fertility and Sterility. 2013; 100(3): 889-894. doi: 10.1016/j.fertnstert.2013.05.027
113. Fletcher NM, Saed MG, Abu-Soud HM, Al-Hendy A, Diamond MP, Saed GM. Uterine fibroids are characterized by an impaired antioxidant cellular system: potential role of hypoxia in the pathophysiology of uterine fibroids. Journal of Assisted Reproductive Genetics. 2013; 30(7):969-974.
114. Nair S, Saed GM, Atta HM, et al. Towards gene therapy of postoperative adhesions: fiber and transcriptional modifications enhance adenovirus targeting towards human adhesion cells. Gynecologic and Obstetric Investigation. 2013; 76(2): 119-124. doi: 10.1159/000353426
115. Detti L, Uhlmann RA, Lu M, et al. erum markers of ovarian reserve and ovarian histology in adult mice treated with cyclophosphamide in pre-pubertal age. Journal of Assisted Reproduction and Genetics. 2013; 30(11): 1421-1429. doi: 10.1007/s10815-013-0087-x
116. Fletcher NM, Saed MG, Abu-Soud HM, Al-Hendy A, Diamond MP, Saed GM. Uterine fibroids are characterized by an impaired antioxidant cellular system: potential role of hypoxia in the pathophysiology of uterine fibroids. 2013.
117. Belotte J, Fletcher NM, Awonuga AO, et al. The role of oxidative stress in the development of Cisplatin resistance in epithelial ovarian cancer. Reproductive Sciences. 2014; 21(4): 503-508. doi: 10.1177/1933719113503403
118. Fletcher NM, Awonuga AO, Saed MG, Abu-Soud HM, Diamond MP, Saed GM. Lycopene, a powerful antioxidant, significantly reduces the development of the adhesion phenotype. Systems Biology in Reproductive Medicine. 2014; 60(1): 14-20.
119. Detti L, Uhlmann RA, Zhang J, et al. Goserelin fosters bone elongation, but does not prevent ovarian damage in cyclophosphamide-treated prepubertal mice. Fertility and Sterility. 2014; 101(4): 1157-1164.e.1. doi: 10.1016/j.fertnstert.2013.12.028
120. Fletcher NM, Abuanzeh S, Saed MG, Diamond MP, Abu-Soud HM, Saed GM. Nicotinamide adenine dinucleotide phosphate oxidase expression is differently regulated to favor a pro-oxidant state that contributes to postoperative adhesion development. Reproductive Sciences. 2014; 21(8): 1050-1059.
121. Fletcher NM, Saed MG, Abuanzeh S, et al. Nicotinamide adenine dinucleotide phosphate oxidase is differentially regulated in normal myometrium versus leiomyoma. Reproductive Sciences. 2014; 21(9): 1145-1152.
122. Awonuga AO, Belotte J, Abuanzeh S, Fletcher NM, Diamond MP, Saed GM. Advances in the pathogenesis of adhesion development: the role of oxidative stress. Reproductive Sciences . 2014; 21(7): 823-836.
123. Goud PT, Goud AP, Najafi T, et al. Direct real-time measurement of intra-oocyte nitric oxide concentration in vivo. PLoS One. 2014; 9(6): e98720. doi: 10.1371/journal.pone.0098720
124. Abu-Soud HM, Maitra D, Shaeib F, et al. Disruption of heme-peptide covalent cross-linking in mammalian peroxidases by hypochlorous acid. Journal of Inorganic Biochemistry. 2014; 140: 245-254. doi: 10.1016/j.jinorgbio.2014.06.018
125. Belotte J, Fletcher NM, Alexis M, et al. Sox2 gene amplification significantly impacts overall survival in serous epithelial ovarian cancer. Reproductive Sciences. 2014.
Maxwell E Lapham Professor of Gynecologic Oncology
Director, Tulane Minority-Based Community Clinical Oncology Program
Tulane University School of Medicine
New Orleans, LA, USA
Dr. Robinson is currently the Maxwell E Lapham Professor of Gynecologic Oncology at Tulane University School of Medicine. He also serves as Principal Investigator and Director for Tulane’s Minority-Based Community Clinical Oncology Program, as well as Director of Tulane’s “Woman to Woman” Survivor Advocacy program and Medical Director of Grace House, a New Orleans-based inpatient Substance Abuse Rehab Center for Women.
Dr Robinson completed Residency training in Obstetrics and Gynecology at Tulane University School of Medicine/New Orleans in 1989, and Fellowship in Gynecologic Oncology at the University of Southern California/LA County in 1992. He has worked in both academic and private practice positions since then, with a career-long commitment to serving indigent and ethnic minority women. In particular, he has worked hard to create opportunities for those women to participate in cancer prevention and treatment research, which has traditionally failed to include representative numbers of ethnic minorities.
He sits on the Cancer Prevention and Control committee and Health Disparities committee of the NRG Cooperative group cancer research program, the Health Economics and Coding Committee of the American Congress of Obstetrics and Gynecology, and is Chairman of the Coding Committee of the Society of Gynecologic Oncology.
Currently he is working to build a Cancer Research and Prevention program in inner city New Orleans, with emphasis on 1) Prevention of cancer in this community; and 2) reducing the barriers to participation in clinical research that exist among local indigent and ethnic minority residents.
His research interests include: HIV infection and cancer in women, intraperitoneal chemo- and immunotherapy for ovarian cancer, Survivorship research, and Coding, Nomenclature and Economics of cancer.
• American College/Congress of Obstetricians and Gynecologists Junior Fellow-1987 Fellow – 1993 to Present
• Health Economics and Coding Committee-2013- Present
• Western Association of Gynecologic Oncology-1994- Present
• American Society of Clinical Oncology- 1994 – Present
• Society of Gynecologic Oncologists/Oncology Fellow – 1996 – Present
• Foundation for Women’s Cancer (formerly Gynecologic Cancer Foundation) Member-1995-present
• Liaison, N.E.D. (No Evidence of Disease) -2009- Present
• Society of Critical Care Medicine -1994 – Present
• Northwest Texas Hospital Pharmacy and Therapeutics Committee - 2000- Present
• Northwest Texas Hospital Cancer Committee 2001-Present
• Texas Medical Board, Case Reviewer- 2005- Present
1. Dixit SN, Robinson W, Dixit P, Kang A. Immunochemistry of 7s Domain of Type IV Collagen. Connective Tissue Research. 1984; Vol. 12: 297-306.
2. RobinsonW, DeShazo R. Effects of HIV infection on pregnancy. A clinical and immunologic evaluation. Annals of Allergy. 1991;Vol. 676: 350-354.
3. Zheng J, Robinson W, Ehlen TE, Yu M, Dubeau L. Distinction of low grade from high-grade human ovarian carcinomas on the basis of losses of heterozygosity on chromosomes 3,6 and 11 and HER-2/neu gene amplification. Cancer Research. 1991; Vol. 51(14): 4045-4051.
4. Robinson W, Curtin JP, Morrow CP. Operative staging and conservative surgery in the management of low malignant potential ovarian tumors. Inter J Gynecol Cancer. 1992; Vol.2: 113-118. doi: 10.1046/j.1525-1438.1992.02030113.x
5. Robinson W, Muderspach LI. Spinal cord compression in metastic cervical cancer. Gyn. Oncol. 1993; 48: 209-271. doi: http://dx.doi.org/10.1006/gyno.1993.1046
6. Robinson W. Management of ovarian tumors of low malignant potential. The Female Patient. 1994; 19: 45-58.
7. Robinson W, Fleischer M. Prenatal human immunodeficiency virus testing and patient management by obstetricians in a high seroprevalence community. Infect Dis Obstet Gynecol. 1994; 2: 25-29. doi: 10.1155/S1064744994000359
8. Devito JR, Robinson W. Gynecological surgical outcomes among asymptomatic human immunodeficiency virus-infected women and uninfected control subjects. J Louis St Med Soc. 1995; 147: 109-112.
9. Robinson W, Wiley D, Van Dyke R. The effect of successive single gestation pregnancies on the course of maternal HIV disease and perinatal transmission. Infect Dis Obstet Gynecol. 1995; 2: 251-254. doi: 10.1155/S1064744995000135
10. Freeman SM, McCune C, Robinson W, et al. The treatment of ovarian cancer with a gene-modified cancer vaccine: A Phase I Study. Human Gene Therapy. 6: 927-939, 1995. doi: 10.1089/hum.1995.6.7-927.
11. Simmons B, Robinson W, Meleg-Smith S. An 81-year-old woman with an abdominal mass. J La State Med Soc. 1995; 147: 512-515.
12. Freeman SM, Marrogi AJ, Ramesh R, Robinson W. Suicide Gene Therapy for the treatment of ovarian cancer. Cancer Detection and Prevention. 19: 111-112, 1995.
13. Robinson W, Tirpack J. The predictive value of LEEP specimens with involved margins for residual dysplasia. Int J Gynecol Oncol. 1996; 6: 140-144. doi: 10.1046/j.1525-1438.1996.06020140.x
14. Robinson W, Champlin S. A trial of secondary closure vs second intention closure in surgical wound separation. J Gynecol Tech. 2: 13-18, 1996.
15. Hamilton C, Robinson W. Femoral artery occlusion following pelvic cancer surgery. Gynecol Oncol. 1996; 63: 151-153. doi: http://dx.doi.org/10.1006/gyno.1996.0296
16. Merogi AJ, Marrogi AJ, Ramesh R, Robinson W, Fermin CD, Freeman SM. Tumor-host interaction: analysis of cytokines, growth factors and tumor infiltrating lymphocytes in ovarian carcinomas. Human Pathol. 1997; 28: 321-331. doi: 10.1016/S0046-8177(97)90131-3
17. Robinson W, Webb S, Tirpack S, Degefu S, OGuinn AG. Management of cervical intraepithelial neoplasia during pregnancy with LOOP excision. Gynecol Oncol. 1997; 64: 153-155. doi: 10.1006/gyno.1996.4546
18. Robinson W, Roberts A, Halabi S, Adams J. Risk Factors for margin involvement in specimens generated by LEEP excision of the cervix. J Gynecol Tech. 1997; 3: 17-20.
19. Robinson W, Barnes S, Adams S, Perrin M. Histology/Cytology discrepancies in HIV-infected obstetric patients with normal pap smears. Gynecol Oncol. 1997; 65: 430433. doi: 10.1006/gyno.1997.4683
20. Robinson W, Lund ED, Adams J. The predictive value of LEEP specimen margin status for residual/recurrent cervical intraepithelial neoplasia. Int J Gyncol Oncol. 8: 109-112, 1998. doi: 10.1046/j.1525-1438.1998.97112.x
21. Robinson W, Adams J, OQuinn AG, Freeman S. Vaccine therapy for ovarian cancer using Herpes Simplex Virus Thymidine Kinase (HSV-TK) suicide gene transfer technique: A Phase I Trial. Gene Ther Molec Biol. 1998; 2: 31-40.
22. Kahan Z, Arencibia J, Csernus V, et al. Expression of growth hormone releasing-hormone (GHRH) mRNA and the presence of biologically active GHRH in human breast, endometrial and ovarian cancers. J Clinical Endocrin and Metabo. 1999; 84(2): 582-589. doi: 10.1210/jc.84.2.582
23. Robinson WR, Mamdoohin N, Adams J, Kline R. Technical Aspects Intraperitoneal Adminstration of a Gene-Modifed Ovarian Cancer Vaccine. J Gynecol Tech. 1999; 5: 79-82.
24. Lin WM, Michalapulos EA, Dhurandar N, et al. Allelic loss and microsatellite alterations of chromosome 3p14.2 are more frequent in recurrent cervical dysplasias. Clin Canc Res. 2000; 6: 1410-1414.
25. Lavey RS, Liu PY, Greer BE, et al. Recombinant human eryghropoietin (EPO) as an adjunct to radiation therapy (RT) and cisplatin for stage IIB-IVA carcinoma of the cervix: a Southwest Oncology Group study. Radiother Oncol. 2000; 56(suppl 1): A-330, S92.
26. Robinson W, Hamilton CA, Micheals SH, Kissinger P. The effects of excisional therapy and highly active antiretroviral therapy on cervical intraepithelial neoplasia in human immunodeficiency virus-infected women. Am J Obstet Gynecol. 2001; 184(4): 538-43. doi: http://dx.doi.org/10.1067/mob.2001.111103
27. Robinson W, Freeman D. Improved outcome of cervical neoplasia in HIV-infected women in the highly active antiretroviral therapy (HAART) era. AIDS Patient Care and STDs. 2002; 16(2): 61-65. doi: 10.1089/10872910252806108
28. Robinson W, Luck M, Morris K, Pruitt B. Gender differences in hospice utilization by cancer patients in an end-of-life transition program. JAMWA. 2002; 57(2): 1-3.
29. Robinson W, Andersen J, Darragh T, Kendall M, Clark R, Maiman M. Isotretinoin for low grade cervical dysplasia in human immunodeficiency virus-infected women. Obstet Gynecol. 2002; 99(5): 777-784. doi: 10.1016/S0029-7844(02)01949-X
30. Clark R, Kendall M, Robinson W. Progression of cervical disease among adolescents infected with human immunodeficiency virus with low grade squamous intraepithelial lesions. JAIDS. 2002; 31(5): 543-545.
31. Robinson W, Luck M, Kendall M, Darraugh T. The predictive value of cytology in HIV-infected women with low grade squamous cervical lesions: A sub-study of a randomized, Phase III chemoprevention trial. Am J Obstet Gynecol. 2003; 188(4): 896-900. doi: 10.1067/mob.2003.205
32. Nouriani M, Bahador A, Berek JS, et al. Detection of residual subclinical ovarian carcinoma after completion of adjuvant chemotherapy. Clin Cancer Res. 2004; 10(8): 2681-6. doi: 10.1158/1078-0432.CCR-0523-03
33. Lavey RS, Liu PY, Greer BE, et al. Recombinant human erythropoietin (EPO) as an adjunct to radiation therapy and cisplatin for stage IIB-IVA carcinoma of the cervix: a Southwest Oncology Group Study. Gynecol Oncol. 2004; 95: 145-151. doi: http://dx.doi.org/10.1016/j.ygyno.2004.07.009
34. Robinson WR, Omar H, Blades N. Toxicity of Intraperitoneal Chemotherapy may be related to Age in Women Treated for Optimally Debulked Ovarian Cancer. Commun Oncol. 2005; 2: 271-275.
35. Luck MB, McIntire M, Blades N, Robinson WR. Characteristics of Women with Gynecologic Cancers who enter Clinical Trials. J Reprod Med. 2005; 50: 481-485.
36. Robinson WR, Luck M, Omar H, Blades N, Morris K, Coscia J. A Pilot Study of Bone Density Loss in Menopausal Women Treated with Chemotherapy for Cancer. Support Care Cancer. 2005; 13(8): 663-667. doi: 10.1007/s00520-005-0798-3
37. Dadabayev AR, Wang Z, Zhang Y, Zhang J, Robinson WR, Lim SH. Cancer Immunotherapy Targeting Sp17: When should the Laboratory Findings Be Translated to the Clinics? Am J Hemat. 2005; 80: 6-11. doi: 10.1002/ajh.20415
38. Smith HO, Jiang C, Weiss GR, et al. Tiripazamine plus Cisplatinum in Advanced or Recurrent Carcinoma of the Uterine Cervix: A Southwest Oncology Group Study. Int J Gynecol Cancer. 2006; 16(1): 298-305.
39. English CA, Pruitt P, Robinson WR. Detecting Asymptomatic Endometrial Carcinoma by Combined PET/CT. Commun Oncol. 2006; 3: 246,255. doi: 10.1016/S1548-5315(11)70692-1
40. Robinson WR, Cunningham AJ, Rogers AS. Deep Vein Thrombosis Management in Women with Cancer. Support Palliat Canc Care. 2006; 3(1): 1-4.
41. Robinson WR. What Would You Do? Gynecol Oncol. 2007; 104: 5-7.
42. English CA, Robinson WR. Primary adenocarcinoma of the sigmoid colon diagnosed by uterine curettage: a case report. Commun Oncol. 2007; 4(3): 402-403. doi: 10.1016/S1548-5315(11)70147-4
43. Wright SE, Rewers-Felkins KA, Quinlin IS, et al. MHC-unrestricted lysis of MUC1-expressing cells by human peripheral blood mononuclear cells. Immun Invest. 2008; 37: 215-225. doi: 10.1080/08820130801967874.
44. Robinson WR, Barnett G, Rogers AS. Neoadjuvant chemotherapy prior to intraperitoneal chemotherapy in women with advanced ovarian cancer. Commun Oncol. 2008; 5(7): 376-380.
45. Robinson WR, Davis N, Rogers AS. Paclitaxel maintenance chemotherapy following intraperitoneal chemotherapy for ovarian cancer. Int J Gynecol Cancer. 2008; 18(5): 891-895. doi: 10.1111/j.1525-1438.2007.01118.x
46. Robinson WR, Coberly C, Beyer J, Lewis A, Ballard K. Office-Based Intraperitoneal Chemotherapy for Ovarian Cancer. J Oncol Practice. 2008; 4(5): 225-228. doi: 10.1200/JOP.0858503.
47. Robinson WR, Ritter J, Rogers A, Tedjarati S, Lieberenz C. Clinical Trial Participation is Associated with Improved Outcome in Women with Ovarian Cancer. Int J Gynecol Cancer. 2009; 19(1): 124-128. doi: 10.1111/IGJ.0b013e31819a1ce8
48. Tiersten A, Liu PY, Smith H, et al. Phase II Evaluation of Neoadjuvant Chemotherapy and Debulking Followed by Intraperitoneal Chemotherapy in Women with Stage III and IV Epithelial Ovarian, Fallopian Tube or Primary Peritoneal Cancer: Southwest Oncology Group Study S0009. Gynecol Oncol. 2009; 111(3): 444-449. doi: 10.1016/j.ygyno.2008.10.028.
49. Markman M, Smith Ho, Moon J, et al. Southwest Oncology Group Trial S9912: Inrtraperitoneal Cisplatin and Paclitaxel plus Intravenous Paclitaxel and Pegylated Liposomal Doxyrubicin as Primary Chemotherapy of Small-Volume Residual Stage III Ovarian Cancer. Gynecol Oncol. 2009; 114(2): 206-209. doi: 10.1016/j.ygyno.2009.04.023.
50. Robinson WR, Perry EK, Beyer J, Lieberenz C. Intraperitoneal Chemotherapy for Ovarian Cancer. Commun Oncol. 2010; 7(2): 1-6.
51. Robinson WR, Beyer J. Factors affecting the completion of intraperitoneal chemotherapy for ovarian cancer. Int J Gynecol Oncol. 2010; 20(1): 70-74. doi: 10.1111/IGC.0b013e3181c7f670.
52. Tiersten A, Liu PY, Smith H, et al. Chemtherapy Resistance as a Predictor of Progression-Free Survival in Ovarian Cancer Patients treated with Neoadjuvant Chemotherapy and Surgical Cytoreduction Followed by Intraperitoneal Chemotherapy: A Southwest Oncology Group Study. Oncology. 2010; 77(6): 395-399.
53. Ballard KS, Tedjarati SS, Robinson WR, Homesley H, Thurston E. Embryonal Rhabdomyosarcoma: Adjuvant and Ex Vivo Assay Directed Chemotherapy. Int J Gynecol Cancer. 2010; 20(4): 561-563. doi: 10.1111/IGC.0b013e3181d320dd.
54. Robinson WR, Beyer J. The Impact of Shifting From Office-Based to Hospital-Based Treatment Facilities on the Administration of Intraperitoneal Chemotherapy for Ovarian Cancer. J Oncol Practice. 2010; 6(5): 232-235. doi: 10.1200/JOP.000058
55. Li, CC, Robinson WR, Rew L. Factors Affecting Sexual Function and Sexual Satisfaction among Females with or without Rectal Cancer or Gynecological Cancer. Univ Texas Dig Repos. 2011;
56. Robinson WR, Griffin S, Beyer J, Kanjanavaikoon P. Extraperitoneal Metastases from Recurrent Ovarian Cancer. Int J Gynecol Cancer. 2012; 22(1): 43-46. doi: 10.1097/IGC.0b013e31823532ce.
57. Dobranski MJ, Wright SE, Robinson WR, Felkins KA, Phillips CA. Immunotherapy With IL-10 and IFN-γ Producing CD4 Effector Cells Modulate Natural And Inducible CD4 TReg Cell Subpopulation Levels: Observations In Four Cases Of Patients With Ovarian Cancer. Cancer Immun Immunotherapy. 2012; 61(6): 839-854. doi: 10.1007/s00262-011-1128-x
58. Wright S, Dobranski MJ, Felkins KA, et al. Cytotoxic T-Lymphocyte Immunotherapy for Ovarian Cancer: A Pilot Study. J Immunotherapy. 2012; 35(2): 196-204. doi: 10.1097/CJI.0b013e318243f213
59. Robinson WR. Neoadjuvant Chemotherapy is rarely the Easy Way Out. J Clin Oncol. 2012; 30(13): 1563-4. doi: 10.1200/JCO.2011.40.8401
60. Alvarez RD, Gray HJ, Timmons, PF, Robinson WR, et al. We need a new paradigm in gynecologic cancer care: SGO proposes solutions for delivery, quality, and reimbursement policies. Gynecol Oncol. 2013; 129: 3-4. doi: 10.1016/j.ygyno.2013.02.010
61. Robinson WR, Cantillo E. Debulking Surgery and Intraperitoneal Chemotherapy are Associated with Decreased Morbidity in Women Receiving Neo-Adjuvant Chemotherapy for Ovarian Cancer. Int J Gynecol Cancer In Press. 2014; 24(1):43-47. doi: 10.1097/IGC.0000000000000009.
62. Robinson W. Gynecologic Cancer Research at a Crossroads. Gynecol Obstet Res Open J. 2014; 1(1): e1- e2. doi: 10.17140/GOROJ-1-e001
Head of Labor and Delivery
Department of Obstetrics and Gynecology
Hadassah Medical Center, Ein Karem
• (1976-1983): Medical school, Ben Gurion University-Israel, M.D
• (1990-1997): Residency, Soroka Medical Center-Israel, Obstetrics and Gynecology
• (1997-99): Fellowship, Toronto University, Maternal- Fetal Medicine
• (2000-2002): MA health organization, Ben Gurion University- Israel, Health Management
POSITIONS AND EMPLOYMENT:
• (2012-2014)- Director of Maternal-Fetal Unit Hadassah Hebrew University Medical Center ,Jerusalem ,Israel
• (2002 -11)- Director of labor and delivery center Hadassah University Hospital
• (2005)- Member, Medical School Admissions Committee
• (2005 - 08)- Member, Israeli Medical Association Committee of Basic Sciences in Obs &Gyn
• (2008 -13)- Member, Hadassah Medical School Educational Committee
• (2008)-Member, National Audit Committee on Maternal-Fetal Medicine
• (2009 -13)- Member, Hadassah Research Committee
• (2009)- Member, International Maternal Health Task Force
• (2010 -13)- Director, Behavioral Perinatal Geneticresearch Laboratory at Hadassah
• (2012)- Senior Lecturer Hebrew University Faculty of Medicine
• (2012-2013)- Member of Israel- Canada Hebrew University research group on Autism
• (2011-3)- Member, COST (European Union Committee of Research on Autism)
• (2013-4)- Chairman ,committee of internship ,Hebrew University Medical school
• (2014)- Member of the Israeli National internship board examination
His research interests include: Maternal-Fetal aspects of mental helath, Biological markers of Autism during pregnancy.
Awards and prizes
• 1983 Completed 6th year of medical school with Honors
• 1985 Award of the President of Israel Haim Hertzog ,for medical contribution made to the community
• 1996 Elected as the” Best Lecturer” by 6th year medical students BGU
• 1999 Prize of the Admiral of the Israeli Navy for “Creative thinking”
• 2005-08 “Best teacher" list . Hebrew University Medical School
• 2012- Prize of the chairman of Hadassah to Bat Ami- sexual attack relief team (group prize)
• 2012- “Best teacher" list. Hebrew University Medical School
• 2013 -“Best teacher" list. Hebrew University Medical School
National and international committees
• 2007-11 Israeli Medical Association, member of residency thesis evaluation committee
• 2008-09 Ministry of health, Chairman of an Obstetrics audit committee
• 2009 Israeli ministry of health department pharmacology; ad hoc evaluator of research studies
• 2011 Cost –European cooperation in the field of scientific and technical research; Action BM1004: Enhancing the scientific study of early autism
• 2012 Member of the Israeli national boards examination in Obstetrics and Gynecology
• 2012 Israeli Ministry of Health – consultant for medico legal cases in perinatal medicine
• 2012-13 Israeli board of the Harris foundation
• 2013 –14Member of the Israeli National committee of the Society of Psychosomatic Obstetrics and Gynecology
• 2014 - Member of the National Scientific committee of internship and medical licensure examinations.
Selected peer-reviewed original papers ( Last 5 years)
1. Mankuta D, Goldner I, Knafo A. Inter-twin Birth Weight Differences and Conduct Problems in Early Childhood. Archives of Pediatrics & Adolescent Medicine. 2010; 164(5): 457-466. doi: 10.1001/archpediatrics.2010.63
2. Kaitz M, Maytal HR, Devor N, Bergman L, Mankuta D. Maternal anxiety, mother-infant interactions, and infants response to challenge. Infant Behav Dev. 2010; 33(2): 136-148. doi: 10.1016/j.infbeh.2009.12.003.
3. Mankuta D, Nadjari, DC, Pomp G. Isolated Fetal Intra-Abdominal Umbilical Vein Varix, Clinical Importance and Recommendations. J Ultrasound Med. 2011; 30: 273-276.
4. Riebold M, Mankuta D, Lerer E, et al. All-trans retinoic acid upregulates reduced CD38 transcription in lymphoblastoid cell lines from autism spectrumdisorder. Mol Med. 2011; 17: 799-806. doi: 10.2119/molmed.2011.00080
5. Ebstein RP, Mankuta D, Yirmiya N, Malavasi F. Are retinoids potential therapeutic agents in disorders of social cognition including autism? FEBS Lett. 2011; 585(11): 1529-1536. doi: 10.1016/j.febslet.2011.05.004
6. Ebstein RP, Knafo A, Mankuta D, Chew SH, Lai PS. The contributions of oxytocin and vasopressin pathway genes to human behavior. Horm Behav. 2012; 61(3): 359-379. doi: 10.1016/j.yhbeh.2011.12.014
7. Gamliel M, Ebstein R, Yirmiya N, Mankuta D. Minor fetal sonographic findings in autism spectrum disorder. Obstet Gynecol Surv. 2012; 67(3): 176-186. doi: 10.1097/OGX.0b013e31824bb5d6.
8. Steinman G, Mankuta D. Insulin-like growth factor and the etiology of autism. Med Hypotheses. 2013; 80(4): 475-480 doi: 10.1016/j.mehy.2013.01.010
9. Steinman G, Mankuta D. Breastfeeding as a possible deterrent to autism – A clinical perspective. Med Hypotheses. 2013. doi: 10.1016/j.mehy.2013.09.013
10. Hochler H, Yaffe H, Schwed P, Mankuta D. Safety of trial of labor after cesarean delivery in grandmultiparous women. Obstet Gynecol. 2014; 123: 304-308. doi: 10.1097/AOG.0000000000000082
Adult Cancer Program, Prince of Wales Clinical School
Level 2, Lowy Cancer Research Centre C25
The University of New South Wales
Sydney, NSW, 2052 , Australia
Dr. Khanna, is a Clinician-Scientist who joined the Adult Cancer Program at the Lowy Cancer Research Centre in 2012. He obtained a MD/PhD fellowship from the Academy of Finland as part of the Graduate Program (TGPBB), University of Tampere, Finland. His thesis was heavily focused on understanding the mechanisms regulating the expression of a recently identified oncoprotein, CIP2A (Cancerous Inhibitor of Protein Phosphatase 2A) and its clinical relevance in human cancers. During his MD/PhD studies, he authored five manuscripts, three as first author. His projects have had translational implications and have been published in the leading journals of the field. In his first original research manuscript (Khanna et al, JNCI 2009), he identified a positive feedback loop between CIP2A and MYC, opened up opportunities to target MYC in human cancers without impacting the normal cell population. This work has been recognized globally, as evidenced by the international awards (EACR-Young Cancer Researcher Award, CELL Press Special Commendation Award) and the number of citations the paper has received. In his other major project, he delineated a mechanism by which constitutive DNA-damage promotes cancer growth. These findings, also holding significant translational relevance, have captured the attention of both the academia and the industry. The Scientist of the Year (2011) Award- Finland and the AACR-GlaxoSmithKline Outstanding Clinical Scholar Award at the annual AACR meeting in Orlando, USA, and special highlight by Nature-SciBX are a testimony to this. My pioneering work has resulted in invitations to write the first comprehensive review on CIP2A in 2013 for Cancer Research, the most cited cancer research journal. Lately, he received the prestigious NHMRC-project grant (role CIA) and NHMRC-Peter-Doherty early career fellowship for executing my ideas on combatting Glioblastoma. In summary, his research experience includes actual translational discoveries (novel oncogenic pathways and targets), validation (in human tumours) and prospective commercialization (patents) of discoveries.
His general research interests include: Carcinogenesis and Drug resistance and Specific areas of interests include DNA-damage, Cancer Stem cells, Kinases and Phosphatases, Solid tumours like ovarian tumours, Breast tumours, Glioblastoma, Prostate cancer and Neuroblastomas.
ACADEMIC AND PROFESSIONAL AWARDS AND HONORS
• (2015-2018) the prestigious NHMRC (Peter Doherty) Early Career Biomedical Fellowship
• (2014) ComBio 2014 Early Career Researcher Award, Canberra, Australia
• (2012) Finalist for Thompson Prize, Sydney Protein Group, University of Western Sydney, Sydney, Australia
• (2011) Voted the Scientist of the Year-Finnish Union of University Researchers and Teachers (FUURT), Helsinki, Finland
• (2011) The American Association for Cancer Research (AACR)-GlaxoSmithKline Outstanding Clinical Scholar Award, at the 102nd Annual Meeting, Orlando, Florida, USA
• (2010) European Association for Cancer Research (EACR) Meeting Bursaries: EACR-21, Oslo, Norway, Meeting Bursary Award Winner
• (2010) Nomination for the British Association for Cancer Research (BACR) Hamilton Fairley Young Investigator Award at the National Cancer Research Institute (NCRI), Liverpool, UK
• (2010) Selected for the International Talent Program (ITP) for Life Sciences & Health-Ministry of Economic Affairs Innovation Program for Life Sciences & Health, Amsterdam, Netherlands
• (2010) Best poster presentation-TGSBB-Summer School, Muurikka, University of Tampere, organised by Prof. Howy Jacobs (head of the graduate school)
• (2009) European Association for Cancer Research (EACR) Symposium Bursary: “Transcription & Cancer”, University of Cambridge, United Kingdom
• (2009) The prestigious European Association for Cancer Research (EACR) Young Cancer Researcher Award - Highly Commended at ECCO 15 -34 ESMO, Berlin, Germany
• (2008) European Association for Cancer Research (EACR) Meeting Bursaries: EACR-20 Lyon, France - Meeting Bursary Award Winner
• (2008) CELL Press Special Commendation Award for Highest scored abstract, EACR-20, France
• (2008) Pezcoller Best Poster Prize: EACR-20, Lyon, France
• (2010-2012) British Association for Cancer Research (BACR)
• (2010-2012) The Finnish Biochemical, Biophysics and Microbiology Society (part of FEBS)
• (2013-Present) Australian Society for Biochemistry and Molecular Biology (ASBMB)
• (2012-Present) Sydney Protein Group (SPG)
• (2009-Present) American Association for Cancer Research (AACR)
• (2011-Present) American Society for Clinical Oncology (ASCO)
• (2009-Present) European Society for Medical Oncology (ESMO)
• (2008-Present) European Association for Cancer Research (EACR)
• (2012-Present) Clinical Oncology Society of Australia (COSA)
Selected Scientific Publications in the Last 5 Years
1. Khanna A, Bockelman C, Hemmes A, et al. C-Myc-dependent regulation and prognostic role of CIP2A in gastric cancer. Journal of the National Cancer Institute. 2009; 101: 793-805.
2. Khanna A, Okkeri J, Westermarck J. Atlas of Genetics and Cytogenetics in Oncology and Haematology. KIAA1524. 2010; 14 (10): 976-978.
3. Khanna A, Okkeri J, Bilgen T, et al. Ets-1 mediates MEK–dependent CIP2A expression in human cancers. PLoS one. 2011; 6(3): e17979. doi: 10.1371/journal.pone.0017979
4. Mathiasen D, Egebjerg C, Andersen SH, et al. Identification of a c-Jun N-terminal kinase-2-dependent signal amplification cascade that regulates c-Myc levels in ras transformation. Oncogene. 2012; 31(3): 390-401. doi: 10.1038/onc.2011.230
5. Laine A, Sihto H, Come C, et al. E2F1- CIP2A feedback loop prevents senescence induction in breast cancer cells with inactive p53. Cancer Discovery. 2013. doi: 10.1158/2159-8290.CD-12-0292.
6. Khanna A, Kauko O, Böckelman C, et al. CHK1 targeting reactivates PP2A tumor suppressor activity in cancer cells. Cancer Research. 2013. doi: 10.1158/0008-5472.CAN-13-1002
7. Khanna A, Pimanda JE, Westermarck J. Cancerous Inhibitor of Protein Phosphatase 2A (CIP2A): An endogenous inhibitor of PP2A complex and an emerging oncogene. Cancer Research. 2013; 3(22): 6548-6553. doi: 10.1158/0008-5472.CAN-13-1994
8. Khanna A. Regulation of Cancerous inhibitor of PP2A (CIP2A) by small molecule inhibitor for c-Jun NH 2-Terminal Kinases (JNKs), SP600125, in Human Fibrosarcoma (HT1080) cells. F1000Research. 2013; 2: 174. doi: 10.12688/f1000research.2-174.v2
9. Khanna A, Patil R, Deshmukh A. Assessment of the Potential of Pathological Stains in Prostate Cancer. Journal of Clinical and Diagnostic Research. 2014; 8 (1): 124-128. doi: http://dx.doi.org/10.7860/JCDR/2014/7002.3938
Links to some media releases
Department of Obstetrics & Gynaecology
The Chinese University of Hong Kong
Tai Po Road, Sha Tin
New Territories, Hong Kong
Dr. Wang Chi Chiu is currently the Deputy Director of Prenatal Genetic Diagnosis Centre, and Division Head and Professor of Department of Obstetrics & Gynaecology at CUHK. Dr. Wang joined the department after his MBBS degree with honours in 1994, and in 1998 and 2011 he received his first PhD in Surgical Sciences from the Chinese University of Hong Kong and his second PhD in Genetics from Japan National Institute of Genetics. Dr. Wang has major research focus in studying congenital fetal anomalies and therapeutic intervention. With wide range of experience in clinical diagnosis, medical research and teaching, Dr. Wang was appointed to the editorial boards and review panels of many important research funding agents and journals. He was also a council member of the Hong Kong Society of Medical Genetics. Dr. Wang has worked on many research projects received a total of 45 million research grants and owned 2 patents. He has published over 120 ISI articles on many acclaimed journals including Gene Dev, Proc Natl Acad Sci U S A, Hum Reprod Update, Angiogenesis, Cell Research, J Biol Chem, Free Radical Biol Med, Mol Hum Reprod, Hum Reprod, and Fertil Steril. His success in fetal medicine research has earned him multiple local and international scholarships and awards.
His research interests include: Reproductive Medicine (endometriosis, miscarriage), Developmental Biology (redox control, gene dosage), Maternal Medicine (preeclampsia, gestational diabetes mellitus), Fetal Medicine (fetal hypoxia, prenatal diagnosis).
• The Science Advisory Board (SAB, US)
• FRSC (Chemistry, UK) ISSCR (Stem Cell, US)
• ESHRE (Human Reproduction & Embryology, Belgium)
• WES (Endometriosis) WFCMS (Chinese Medicine)
• APSEG (Eye Genetics, Asia Pacific)
• HKSMG (Medical Genetics, HK)
• HKPS (Proteomics, HK)
• HKSDB (Developmental Biology, HK)
• OGSHK (O&G, HK) HKSCC (Clinical Chemistry, HK)
• HKSMS (Mass Spectrometry, HK)
RESEARCH AWARDS & SCHOLARSHIPS:
• C. Y. Kwan/Lee Hysan Foundation Endowment Funds/Sino-British Fellowship Trust Fund, Society for Gynecologic Investigation (SGI)
• Japan Society for the Promotion of Science (JSPS)
• Global Scholarship Programme for Research Excellence – CNOOC
• Marine Biological Laboratory (MBL)
• International Federation of Placental Associations (IFPA)
• International Union of Toxicology (IUTOX)
• International Society for Stem Cell Research (ISSCR)
• International Society for Immunology of Reproduction (ISIR)
• The International Federation of Clinical Chemistry and Laboratory Medicine - Forum of European Societies for Clinical Chemistry and Laboratory Medicine (IFCC-FESCC)
• Asia-Association for Research in Vision and Ophthalmology (ARVO)
• Keystone Symposia, Asian-Pacific Federation of Clinical Biochemists (APFCB)
• Human Genome Organisation (HUGO)
• American Association for Clinical Chemistry (AACC)
• Hong Kong Society of Medical Genetics, Australasian Association of Clinical Biochemists (AACB)
• Asian and Pacific Federation of Clinical Biochemistry (APFCB)
• International Federation of Clinical Chemistry and Laboratory Medicine (IFCCLM)
• Hong Kong Society of Clinical Chemistry, German Academic Exchange Service (DAAD)
1. Man GCW, Wang WWJ, Yim APY, et al. A review of pinealectomy-induced melatonin-deficient animal models for the study of etiopathogenesis of adolescent idiopathic scoliosis. Int J Mol Sci. 2014; 15: 16484-16499. doi: 10.3390/ijms150916484
2. Chu KO, Chan SO, Pang CP, Wang CC. Pro-oxidative or Anti-oxidative dilemma of phytochemical polyphenols for therapeutic interventions against inflammation and oxidative insults. J Agric Food Chem. 2014; 62: 4026-4038.
3. Li L, Leung PC, Chung TKH, Wang CC. Systematic review of Chinese Medicine for miscarriage during early pregnancy. Evid-Based Compl Alt Med Article. 2014; 1-16. doi: 10.1155/2014/753856
4. Wang CC, Li L, Lau CBS, Leung PC, Fung KP. Pregnancy Outcomes, Embryonic and Fetal Development in Maternal Exposure to Chinese Medicines. Birth Defects Res Part C: Embryo Today. 2013; 99: 275-291. doi: 10.1002/bdrc.21050
5. Chu CY, Wang CC. Toxicity of melamine: The public health concern. J Environ Sci Heal C. 2013; 31(4): 342-386. doi: 10.1080/10590501.2013.844758.
6. Leung TY, Pooh RK, Wang CC, Lau TK, Choy KW. Classification of pathogenic or benign status of CNVs detected by microarray analysis. Expert Rev Mol Diagn. 2010; 10(6): 717-721. doi: 10.1586/erm.10.68.
7. Ufer C, Wang CC, Borchert A, Heydeck D, Kuhn H. Redox control in mammalian embryo development. Antioxid Redox Sign. 2010; 13(6): 833-875. doi: 10.1089/ars.2009.3044.
10.1089/ars.2009.3044 8. Choy KW, Kwok YKY, Cheng YKY, et al. Rapid detection of chromosomal abnormalities by BACs-on-Beads versus karyotyping: a cytogenetic risk assessment: a prospective observational study. BJOG. 2014; 121(10): 1245-1252.
9. Huang YG, Li W, Wang CC, Wu XK, Zheng JH. Cryptotanshinone reverses ovarian insulin resistance in mice through activation of insulin signaling and the regulation of glucose transporters and hormone synthesizing enzymes. Fertil Steril. 2014; 102(2): 589-596. doi: 10.1016/j.fertnstert.2014.05.012
10. Chong WWS, Lo IFM, Lam STS, et al. Performance of chromosomal microarray for patients with intellectual disabilities/developmental delay, autism, and multiple congenital anomalies in a Chinese cohort. Mol Cytogenet. 2014; 7(34): 1-6. doi: 10.1186/1755-8166-7-34. eCollection 2014.
11. Liang J, Ng KY, Cheng QN, Xia Y, Wang CC, Leung PS. Human fetal liver stromal cell co-cultures enhance the differentiation of pancreatic progenitor cells into islet-like cell clusters. Stem Cell Rev Rep. 2013; 10(2): 280-294. doi: 10.1007/s12015-013-9491-y.
12. Wang CC, Man GCW, Chu CY, et al. Serotonin receptor 6 mediates defective brain development in monoamine oxidase-a deficient mouse embryos. J Biol Chem. 2014; 289(12): 8252-8263. doi: 10.1074/jbc.M113.522094.
13. Deng Y, Wang CC, Choy KW, et al. Therapeutic potentials of gene silencing by RNA interference: principles, challenges, and new strategies. Gene. 2013; 538(2): 217-227. doi: 10.1016/j.gene.2013.12.019.
14. Lee WYW, Zhang T, Lau CPY, Wang CC, CHan KM, Li G. Immortalized human fetal bone marrow-derived mesenchymal stromal cell expressing suicide gene for anti-tumor therapy in vitro and in vivo. Cytotherapy. 2013; 15(12): 1484-1497. doi: 10.1016/j.jcyt.2013.06.010
15. Lo P, Chen Y, Mak KKL, Wong CK, Wang CC, Yuan P. Functional role of Mst1/Mst2 in embryonic stem cell differentiation. pLoS One. 2013; 8(11): e79867. doi: 10.1371/journal.pone.0079867.
16. Wang YF, Li L, Wang CC, Leung LK. Effect of zeranol on expression of apoptotic and cell cycle proteins in murine placentae. Toxicology. 2013; 314: 148-154. doi: 10.1016/j.tox.2013.09.011
17. Li P, Chen Y, Meng XM, et al. Suppression of malignancy by Smad3in mouse embryonic stem cell formed teratoma. Stem Cell Rev Rep. 2013; 9: 709-720. doi: 10.1007/s12015-013-9452-5
18. Chan KY, Zhou L, Xiang P, et al. Thrombopoietin protects against myocardial infarction in rats: improved cardiac functions, regulated gene expression profiles of remodeling, promoted endothelial progenitor cells and neovascularization. Int J Cardiol. 2013; 167:2546-2554.
19. Xu H, Zhang T, Man GCW, et al. Angiogenic vascular endothelial growth factor C is expressed in endometrium and promotes endothelial functions, vascular permeability and angiogenesis and growth of endometriosis. Angiogenesis. 2013; 16:541-551. doi: 10.1007/s10456-013-9333-1
20. Li L, Dou LX, Leung PC, Chung TKH, Wang CC. Chinese herbal medicine for unexplained recurrent miscarriage: Protocol. Cochrane DB Syst Rev. 2013; 6: 1-15.
21. Tang WJ, Huang H, Wang YF, Wong TY, Wang CC, Leung LK. Bisphenol A differentially activates protein kinase C isoforms in murine placental tissue. Toxicol Appl Pharm. 2013; 269(2): 163-168. doi: 10.1016/j.taap.2013.03.016
22. Wang CC, Cheng KF, Lo WM, et al. A randomized, double-blind, multiple-dose escalation study of a Chinese herbal medicine preparation (Dang Gui Buxue Tang) for moderate to severe menopausal symptoms and quality of life in postmenopausal women. Menopause. 2013; 20(2): 223-231. doi: 10.1097/gme.0b013e318267f64e
23. Cheng YK, Wong C, Wong HK, et al. The detection of mosaicism by prenatal BoBs™. Prenat Diagn. 2013; 33: 42-49. doi: 10.1002/pd.4006
24. Chu CY, Chu KO, Ho CS, et al. Melamine in prenatal and postnatal organs in rats. Reprod Toxicol. 2013; 35:40-47. doi: 10.1016/j.reprotox.2012.06.003
25. Wang CC, Xu H, Man GCW, et al. Prodrug of green tea epigallocatchin-3-gallate (Pro-EGCG) as a potent anti-angiogenesis agent for endometriosis in mice. Angiogenesis. 2013; 16: 59-69. doi: 10.1007/s10456-012-9299-4
26. Tang LY, Li L, Borchert A, Lau CBS, Leung PC, Wang CC. Molecular studies of the congenital malformation induced by Largehead Atractylodes Rhizome, the most commonly used Chinese medicine for threatened miscarriage. Mol Hum Reprod. 2012; 18(12): 585-592. doi: 10.1093/molehr/gas034
27. Lee LM, Leung CY, Tang WW, et al. A paradoxical teratogenic mechanism for retinoic acid. Proc Natl Acad Sci USA. 2012; 109: 13668-13673. doi: 10.1073/pnas.1200872109
28. Huang H, Tan W, Wang CC, Leung LK. Bisphenol A induces corticotrophin-releasing hormone expression in the placental cells JEG-3. Reprod Toxicol. 2012; 34: 317-322. doi: 10.1016/j.reprotox.2012.04.008
29. Chung MK, Lau TS, Lui WT, et al. Expression of placental Toll-like receptors-3, -7 and -8 upon placental hepatitis B infection. Placenta. 2012; 33(9): A113.
30. Li L, Dou LX, Neilson JP, Leung PC, Wang CC. Adverse outcomes of Chinese medicines used for threatened miscarriage: a systematic review and meta-analysis. Hum Reprod Update. 2012; 18(5): 504-524. doi: 10.1093/humupd/dms025
31. Wang CC, Li L, Tang LY, Leung PC. Safety evaluation of commonly used Chinese medicines during pregnancy in mice. Hum Reprod. 2012; 27: 2488-2456. doi: 10.1093/humrep/des180
32. Li L, Dou LX, Leung PC, Wang CC. Chinese herbal medicines for threatened miscarriage: Review. Cochrane Database Syst Rev. 2012 ; 5: 1-85. doi: 10.1002/14651858.CD008510.pub2.
33. Leung TY, Wong KM, Wong HK, et al. A retrospective study of BACs-on-Beads (BoBs) technology for identification of chromosome abnormalities compared with QF-PCR and karyotyping in prenatal diagnosis. Am J Obstet Gynecol. 2012; 206 (1): S322 (725). doi: http://dx.doi.org/10.1016/j.ajog.2011.10.743
34. Li L, Tang LY, Man GCW, et al. Potential reproductive toxicity of Largehead Atractylodes Rhizome, the most commonly used Chinese medicine for threatened miscarriage. Hum Reprod. 2011; 26: 3280-3288. doi: 10.1093/humrep/der335
35. Xu H, Becker CM, Lui WT, et al. Green tea epigallocatchin-3-gallate inhibits angiogenesis and suppresses VEGFC/VEGFR2 expression and signaling in experimental endometriosis in vivo. Fertil Steril. 2011; 96: 1021-1028. doi: 10.1016/j.fertnstert.2011.07.008
36. Huang H, Li L, Wang Y, Tang LY, Wang CC, Leung LK. Genistein upregulates placental corticotropin-releasing hormone expression in lipopolysaccharide-sensitized mice. Placenta. 2011; 32(10): 757-762. doi: 10.1016/j.placenta.2011.07.082
37. Liu Ml, Li L, Leung PC, et al. Acupuncture for amblyopia in children. Cochrane Database of Systematic Reviews. 2011; 9: 1-11.
38. Wang CC, Borchert A, Ugun-Klusek A, et al. Monoamine oxidase A expression is vital for embryonic brain development by modulating developmental apoptosis. J Biol Chem. 2011; 286(32): 28322-28330. doi: 10.1074/jbc.M111.241422
39. Chan JYW, Lau CM, Ting TL, et al. Gestational and lactational transfer of melamine following gavage administration of a single dose to rats. Food Chem Toxicol. 2011; 49: 1544-1548. doi: 10.1016/j.fct.2011.03.046
40. Wang CC, Kazuki Y, Oshimura M, Ikeo K, Gojobori T. Gene dosage imbalance of human chromosome 21 in mouse embryonic stem cells differentiating to neurons. Gene. 2011; 481: 93-101. doi: 10.1016/j.gene.2011.04.003
41. Pong JCF, Chu CY, Li WY, et al. Association of hemopexin in tear film and conjunctival macrophages with vernal keratoconjunctivitis. Arch Ophthalmol. 2011; 129: 453-461. doi: 10.1001/archophthalmol.2011.41
42. Chan KYY, Xiang P, Zhou L, et al. Thrombopoietin protects against doxorubicin-induced cardiomyopathy: improves cardiac function and reversely alters specific signaling networks. Eur J Heart Fail . 2011; 13: 366-376. doi: 10.1093/eurjhf/hfr001
43. Huang L, Wong YP, Gu H, et al. Stem Cell-like Properties of human umbilical cord lining epithelial cells and the potential for epidermal reconstitution. Cytotherapy. 2011; 13: 145-155. doi: 10.3109/14653249.2010.509578
44. Lee KY, Fong BSP, Tsang KS, et al. Fetal stromal niches enhance human embryonic stem cell-derived hematopoietic differentiation and globin switch. Stem Cells Dev. 2011; 20: 31-38. doi: 10.1089/scd.2010.0196
45. Chu CY, Chu KO, Chan JYW, et al. Distribution of melamine in rat foetuses and neonates. Toxicol Lett . 2010; 199: 398-402. doi: 10.1016/j.toxlet.2010.10.004
46. Borchert A, Küttner G, Gießmann E, et al. Defining the immunoreactive epitope for the monoclonal anti-human glutathione peroxidase-4 antibody anti-hGPx4 Mab63-1. Immunol Lett. 2010; 133: 85-93. doi: 10.1016/j.imlet.2010.07.006
47. Khaw KS, Ngan Kee WD, Chu CY, et al. Effects of different inspired oxygen fractions on lipid peroxidation during general anaesthesia for elective Caesarean section. Br J Anaesth. 2010; 105: 355-360. doi: 10.1093/bja/aeq154
48. Pong JCF, Chu CY, Chu KO, et al. Identification of Hemopexin in Tear Film. Anal Biochem. 2010; 404(1): 82-85. doi: 10.1016/j.ab.2010.04.036
49. Chu KO, Chan KP, Wang CC, et al. Green tea catechins and their oxidative protection in the rat eye. J Arg Food Chem. 2010; 58(3):1523-1534. doi: 10.1021/jf9032602.
50. Wong HK, Wang CC, Pang CP, Choy KW. Identification of coding and non-coding RNA(s) specific for early human retina development. Mech Dev. 2009; 126 (Suppl.): S169 (09-P063).
51. Chu CY, Poon CW, Pong JCF, Pang CP, Wang CC. Human normal tear Proteome. Graef Arch Clin Exp. 2009; 247: 725-727. doi: 10.1007/s00417-008-0974-5
52. Ng LWC, SK Yip, Wong HK, et al. Adipose-derived stem cells from pregnant women show higher proliferation rate unrelated to estrogen. Human Reprod. 2009; 24(5): 1164-1170. doi: 10.1093/humrep/dep001
53. Xu H, Lui WT, Chu CY, Ng PS, Wang CC, Rogers MS. Anti-angiogenic effects of green tea catechin on an experimental endometriosis mouse model. Human Reprod. 2009; 24(3): 608-618. doi: 10.1093/humrep/den417
54. Kai Y, Wang CC, Kishigami S, Kazuki Y, et al. Enhanced apoptosis during early neuronal differentiation in mouse ES cells with autosomal imbalance. Cell Research. 2009; 19(2): 247-258. doi: 10.1038/cr.2008.305
55. Uehara S, Izumi Y, Kubo Y, et al. Specific expression of Gsta4 in mouse cochlear melanocytes: A novel role for hearing and melanocyte differentiation. Pigm Cell Melanoma Res. 2009 ; 22(1): 111-119. 00513.x doi: 10.1111/j.1755-148X.2008.00513.x
56. Law LW, Lau TK, Fung TY, Leung TY, Wang CC, Choy KW. De novo 16p13.11 microdeletion identified by high resolution array CGH in a fetus with increased nuchal translucency. Br J Obstet Gynaecol. 2009 ; 116(2): 339-343. doi: 10.1111/j.1471-0528.2008.01948.x
57. Choy KW, Wang CC, Yip SK, Chan SCC. High isoprostane level in cardinal ligament-derived fibroblasts and urine sample of women with uterine prolapse. Br J Obstet Gynaecol. 2009 ; 116(1): 127-128. doi: 10.1111/j.1471-0528.2008.01806.x.
58. Khaw KS, Wang CC, Ngan Kee WD, et al. Supplementary oxygen for emergency Caesarean section under regional anaesrhesia. Br J Anaesth . 2009; 102(1): 90-96. doi: 10.1093/bja/aen321
59. Uehara S, Izumi Y, Kubo Y, et al. Analysis of a specific function of the mouse inner ear melanocytes essential for hearing acuity. Genes Genet Syst. 2008 ; 83(6): 485.
60. Choy KW, Liu YM, Chu CY, et al. High isoprostane level in cardinal ligament-derived fibroblasts and urine sample of women with uterine prolapse. Br J Obstet Gynaecol. 2008; 115: 1179-1183. doi: 10.1111/j.1471-0528.2008.01806.x
61. Chu KO, Wang CC, Pang CP, Rogers MS. Method to determine stability and recovery of carboprost and misoprostol in infusion preparations. J Chromat B. 2007; 857: 83-91. doi: 10.1016/j.jchromb.2007.07.016
62. Wang CC, Lui WT, Chu CY, Lau TK, Rogers MS. Dynamic changes of pattern recognition lectins during normal and preeclamptic pregnancy. Placenta. 2007; 28: A. 67(A7. 19).
63. Han YB, Feng HL, Cheung CK, Lam EPM, Wang CC, Haines CJ. Expression of a novel T-complex testis expressed 5(Tctex5) in mouse testis, epididymis and spermatozoa. Mol Reprod Dev. 2007; 74: 1132-1140. doi: 10.1002/mrd.209631.
64. Wang CC, Chu KO, Chong WS, et al. Tea epigallocatechin-3-gallate increased 8-isoprostane level and induced caudal regression in developing rat embryos. Free Radic Biol Med. 2007; 43: 519-527. doi: 10.1515/CLCM. 2007.233.
65. Lai WW, Choy KW, Chu KO, et al. Differential penetrance of ofloxacin and moxifloxacin in human aqueous and vitreous following topical administration. Am J Ophthal. 2007; 144: 315-318.
66. Wang CC, Lui WT, Chu CY, et al. Characterisation of pattern recognition lectins during normal pregnancy in mouse. Hum Reprod. 2007; 22( Suppl 1): i174(P-445).
67. Tang T, Wang CC, Wong YF, et al. Characterizing abberrantly expressed microRNAs in chromosome 7 in cervical carcinoma. Proc Am Assoc Can Res Ann Meeting. 2007; 48: 96.
68. Choy KW, Tang T, Wang CC, et al. Investigating the microRNA profile in cervical cancer. Proc Am Assoc Can Res Ann Meeting. 2007; 48: 706.
69. Chu KO, Ho TC, Chiang WY, Wang CC, Lam DSC, Pang CP. Measuring triamcinolone acetonide in aqueous humor by gas chromatography-electron-capture negative-ion mass spectrometry. J Chromat B. 2007; 847: 199-204. doi: 10.1016/j.jchromb.2006.10.014
70. Kurosaki H, Kazuki Y, Hiratsuka M, et al. A comparison study in the proteomic signatures of multipotent germline stem cells, embryonic stem cells, and germline stem cells. Biochem Biophys Res Commun. 2007; 353(2): 259-267. doi: 10.1016/j.bbrc.2006.12.025
71. Wang CC, Yim KW, Poon TCW, et al. Innate immune response by ficolin binding in apoptotic placenta is associated with the clinical syndrome of preeclampsia. Clin Chem. 2007; 53: 42-52. doi: 10.1373/clinchem.2007.074401
72. Chu KO, Wang CC, Chu CY, Choy KW, Pang CP, Rogers MS. Uptake and distribution of catechins in fetal organs following in utero exposure in rats. Hum Reprod. 2007; 22: 280-287. doi: 10.1093/humrep/del353
73. Ko CH, Li K, Ng PC, et al. Pro-oxidative effects of tea and polyphenols, epigallocatechin-3-gallate and epigallocatechin, on G6PD-defficient erythrocytes in vitro. Int J Mol Med. 2006; 18(5): 987-994. doi: 10.3892/ijmm.18.5.987
74. Leung TN, Choy KW, Chu CY, et al. Specific binding of ficolins to apoptotic trophoblasts in preeclampsia. Hypertens Pregnancy. 2006; 25(S1): 43, O50. doi: 10.1373/clinchem.2007.074401
75. Rogers MS, Wang CC, Li CY, Tam WH, Chu KO, Chu CY. Oxidative stress in mid-pregnancy as a predictor of gestational hypertension and pre-eclampsia. Hypertens Pregnancy. 2006; 25(S1): 76, P007. doi: 10.1111/j.1471-0528.2006.01026.x
76. Rogers MS, Wang CC, Tam WH, Li CY, Chu KO, Chu CY. Oxidative stress in mid-pregnancy as a predictor of gestational hypertension and pre-eclampsia. BJOG-Int J Obstet Gynaecol. 2006; 113: 1053-1059. doi: 10.1111/j.1471-0528.2006.01026.x
77. Borchert A, Wang CC, Ufer C, Schiebel H, Savaskan NE, Kuhn H. The role of phospholipids hydroperoxide glutathione peroxidase(GPx4) isoforms in murine embryogenesis. J Biol Chem. 2006; 281(28): 19655-19664. doi: 10.1074/jbc.M601195200
78. Chan KP, Chu KO, Lai WK, Choy KW, Wang CC, Pang CP. Determination of ofloxacin and moxiflozacin and their penetration in human aqueous and vitreous humor by using HPLC-fluorescence detection. Anal Biochem. 2006; 353: 30-36. doi: 10.1016/j.ab.2006.03.016
79. Chu KO, Wang CC, Chu CY, et al. Pharmacokinetic studies of green tea catechins in maternal plasma and fetuses in rats. J Pharm Sci. 2006; 95(6): 1372-1381. doi: 10.1002/jps.20594
80. Chu CY, Xiao X, Zhou XG, et al. Metabolomic and bioinformatics analyses in asphyxiated neonates. Clin Biochem. 2006; 39(3): 203-209. doi: 10.1016/j.clinbiochem.2006.01.006
81. Choy KW, Wang CC, Ogura A, et al. Molecular characterization of developmental gene in eyes: through data-mining on integrated transcriptome databases. Clin Biochem. 2006; 39(3): 224-230. doi: 10.1016/j.clinbiochem.2005.12.005
82. Choy KW, Wang CC, Ogura A, et al. Genomic annotation of 15, 809 ESTs identified from pooled early gestation human eyes. Physiol Genomics. 2006; 25(1): 9-15. doi: 0.1152/physiolgenomics.00121.2005
83. Xia WJ, Yang M, Fok TF, et al. Partial neuroprotective effect of pretreatment with tanshinone IIA on neonatal hypoxia-ischemia brain damage. Paed Res. 2005; 58: 784-790. doi: 10.1203/01.PDR.0000180550.99162.BC
84. Rogers MS, Wang CC, Lau TK, et al. Relationship between isoprostane concentrations, metabolic acidosis, and morbid neonatal outcome. Clin Chem. 2005; 51: 1271-1274. doi: 10.1373/clinchem.2004.047241
85. Wang CC, Chu KO, Lau TK, et al. Predictive and prognosis values of increased cord blood and neonatal urinary F2-isoprostanes in asphyxiated newborns. Clin Chem. 2005; 51(S6): A104, C-2.
86. Wang CC, Chu KO, Chong WS, et al. Embryotoxicity of green tea catechins during pregnancy. Clin Chem. 2005; 51(S6): A140, C-123.
87. Yim KW, Wang CC, Poon CW, Rogers MS, Lau TK, Leung TN. Identification of putative serum proteins associated with pre-eclampsia. Clin Chem. 2005; 51(S6): A89, B-125.
88. Wang CC, Hwang JS, Gojobori T, Ikeo K. New Implementation of microarray profiling by triple hybridization. Clin Chem. 2005; 51: A196-197, D-129.
89. Wang CC, Tang LY, Choy KW, et al. New transcription factors for early eye formation in mouse. Genes Genet Syst. 2005; 80: 427.
90. Liu BY, Wang CC, Lau TK, et al. Meconium stained liquor(MSL) during labour is associated with raised neonatal cord blood 8-iso-prostaglandin F2α concentration. Am J Obstet Gynecol . 2005; 192: 289-294. doi: 10.1016/j.ajog.2004.06.083
91. Kadota M, Nishigaki R, Wang CC, et al. Proteomic signatures and aberrations of mouse embryonic stem cells containing a single human chromosome 21 in neuronal differentiation: an in vitro model of Down syndrome. Neuroscience. 2005; 129: 325-335. doi: 10.1016/j.neuroscience.2004.06.081
92. Chu KO, Wang CC, Chu CY, Rogers MS, Choy KW, Pang CP. Determination of catechins and catechin gallates in tissues by liquid chromatography with coulometric array detection and selective solid phase extraction. J Chromat B. 2004; 810: 187-195. doi: 10.1016/j.jchromb.2004.07.031
93. Souza AMB, Wang CC, Chu CY, Briton Jones CM, Haines CJ, Rogers MS. In vitroexposure to carbon dioxide induces oxidative stress in human peritoneal mesothelial cells. Hum Reprod. 2004; 19: 1281-1286. doi: 10.1093/humrep/deh164
94. Wang CC, Chu CY, Chu KO, et al. Trolox-equivalent antioxidant capacity(TEAC) assay versus oxygen radical absorbance capacity(ORAC) assay in plasma. Clin Chem. 2004; 50: 952-954. doi: 10.1373/clinchem.2004.031526
95. Chu KO, Wang CC, Rogers MS, Choy KW, Pang CP. Determination of catechins and catechin gallates in biological fluids by liquid chromatography with coulometric array detection and solid-phase extraction. Anal Chim Acta. 2004; 510: 69-76. doi:10.1016/j.aca.2003.12.060.
96. Khaw KS, Ngan Kee WD, et al. Supplementary oxygen for elective caesarean section under spinal anaesthesia: useful in prolonged uterine incision-to-delivery interval? Br J Anaesth. 2004; 92: 518-522. doi: 10.1093/bja/aeh092
97. Wang CC, Kadota M, Nishigaki R, et al. Molecular hierarchy in neurons differentiated from mouse ES cells containing a single human chromosome 21. Biochem Biophy Res Commun. 2004; 314: 335-350. doi: 10.1016/j.bbrc.2003.12.091
98. Chu KO, Wang CC, Rogers MS, Choy KW, Kwok KH, Pang CP. HPLC determination of lignocaine and its metabolite xylidine in aqueous humor. Anal Letter. 2003; 36: 2669-2682.
99. Souza AMB, Wang CC, Chu CY, Lam PM, Rogers MS. The effect of intra-abdominal pressure on the generation of 8-iso prostaglandin F2 during laparoscopy in rabbits. Hum Reprod. 2003; 18: 2181-2188. doi: 10.1093/humrep/deg405
100. Chu KO, Wang CC, Rogers MS, Pang CP. Quantifying F2-isoprostanes in umbilical cord blood of newborn by gas chromatography-mass spectrometry. Anal Biochem. 2003; 316: 2-111-117. doi: 10.1016/S0003-2697(03)00043-5
101. Rogers MS, Yim SF, Li KC, Wang CC, Arumanayagam M. Polyamine oxidase and diamine oxidase activity in cervical mucus associated with premalignant changes in the uterine cervix. Free Radical Biol Med. 2002; 333: S175, 462. doi: http://dx.doi.org/10.1006/gyno.2001.6521
102. Souza AMB, Rogers MS, Wang CC, Yuen PM, Ng PS. Comparison of peritoneal oxidative stress during laparoscopy and laparotomy. J Am Assoc Gynecol Lap. 2002; 10: 65-74. doi: 10.1016/S1074-3804(05)60237-X
103. Chan LY, Chiu PY, Siu SSN, Wang CC, Lau TK. Diclofenac-induced embryotoxicity is associated with increased embryonic 8-iso prostaglandin F2α level in rat whole embryo culture. Reprod Toxicol. 2002; 16: 841-844. doi: 10.1016/S0890-6238(02)00047-3
104. Rogers MS, Yim SF, Li KC, Wang CC, Arumanayagam M. A comparison of the enzymes polyamine oxidase and diamine oxidase in the cervical secretions in cervical intra-epithelial neoplasia. Gynecol Oncology. 2002; 84: 383-387.
105. Khaw KS, Wang CC, Ngan Kee WD, Pang CP, Rogers MS. The effect of high-inspired oxygen fraction during elective Caesarean section under spinal anaesthesia on maternal and fetal oxygenation and lipid peroxidation. Br J Anaesthsia. 2002; 88: 18-23. doi: 10.1093/bja/88.1.18
106. Rogers MS, Murray HG, Wang CC, et al. Oxidative stress in the fetal lamb brain following intermittent umbilical cord occlusions: a path analysis. Br J Obstet Gynaecol. 2001; 108: 1283-1290. doi: 10.1111/j.1471-0528.2001.00297.x
107. Qin Y, Wang CC, Rogers MS, Kuehn H, Pang CP. Determinants of umbilical cord arterial isoprostane at birth. Br J Obstet Gynecol. 2000; 107: 973-981. doi: 10.1111/j.1471-0528.2000.tb10399.x
108. Qin Y, Wang CC, Lau TK, Rogers MS. Colour ultrasounography: a useful technique in the identification of nuchal cord entanglement during labour. Ultrasound Obstet Gynecol. 2000; 15: 413-417. doi: 10.1046/j.1469-0705.2000.00113.x
109. Rogers MS, Wang CC. A comparison of three ultrasound estimates of intrapartum oligohydramnios for prediction of fetal hypoxia-reperfusion injury. Early Human Development. 1999; 56: 117-126. doi: http://dx.doi.org/10.1016/S0378-3782(99)00043-2
110. Rogers MS, Mongellia JM, Tsang B, Wang CC. Fetal and maternal level of lipid peroxidation in term pregnancies. Acta Obstet Gynecol Scand. 1999; 78: 120-124. doi: 10.1034/j.1600-0412.1999.780209.x
111. Rogers MS, Mongelli JM, Tsang KH, Wang CC, Law KP. Lipid peroxidation in cordblood at birth: the effect of labour. Br J Obstet Gynaecol. 1998; 105; 739-744. doi: 10.1111/j.1471-0528.1998.tb10204.x
112. Mongelli JM, Wang CC, Wang W, Pang CCP, Rogers MS. Oxygen free radical activity in the second stage of labor. Acta Obstet Gynecol Scand. 1997; 76: 765-768. doi: 10.3109/00016349709024344
113. Wang CC, Rogers MS. Lipid peroxide in cord blood: a randomised sequential pairs study of prophylactic saline amnioinfusion for intrapartum oligohydramnios. Br J Obstet Gynecol. 1997; 104: 1145-1151.
114. Wang CC, Rogers MS. Lipid peroxide in cord blood: the effect of amniotic fluid volume during labour. Br J Obstet Gynecol. 1997; 104: 1140-1144.
115. Wang CC, Rogers MS. Lipid peroxidation in cord blood: the effects of umbilical nuchal cord. Br J Obstet Gynecol. 1997; 104: 251-255.
116. Rogers MS, Lau TK, Wang CC, Yu KM. Amnioinfusion for the prevention of meconium aspiration during labour. Aust NZ J Obstet Gynecol. 1996; 36: 407-410.
Boston Center for Endometriosis
Brigham and Women’s Hospital
Harvard Medical School
Boston, MA 02115, USA
Dr. Parasar completed his Doctoral Degree in the reproductive Immunogenetics program at Utah State University, Logan, Utah in 2013 which involved his dissertation research to determine expression patterns of Non-classical major his to compatibility complex (MHC) class I proteins in bovine trophoblast cells. Later he began his postdoctoral research fellowship in the Department of Obstetrics and Gynecology at Brigham and Womens Hospital (BWH) and the Boston Center for Endometriosis at Boston Childrens Hospital and BWH. Earlier he completed his DVM and Masters research (MVSc) focusing on animal genetics and breeding.
His research interests include: Understanding genetic and epigenetic mechanisms of pathogenesis of reproductive diseases and to use them in developing strategies to improve pregnancy success rates. He is working within the BCE to develop a stem cell model of endometriosis disease and to understand pathophysiology of the disorder in the pursuit of development of novel therapies.
HONORS AND AWARDS
• Segal Education Award, AmeriCorps 2013
• Cache Valley Cooperative Dairy Scholarship, USU, Logan, UT 2012
• Graduate Student Dissertation Fellowship, USU, Logan, UT 2012
• Junior Research Fellowship, IVRI, Izatnagar 2005
1. Parasar P, Barnett S, Wilhelm A, Rashid K, Davies CJ. Large-scale growth of mouse P815 cells expressing a bovine non-classical major histocompatibility complex class I protein utilizing a pitched-blade bioreactor. BioProcess J. 2012; 11(3): 27-34. doi: http://dx.doi.org/10.12665/J113.Davies.
2. Parasar P, Bhushan B, Yadav JS, Sharma A, Dutt T. DNA polymorphism of major histocompatibility complex Class-II DQA and DQB genes in crossbred cattle (Bos taurus ×Bos indicus). Indian Journal of Animal Sciences. 2011; 81 (7): 769–772.
3. Parasar P. Endometriosis research: need for a stem-cell based experimental model. Gynecol Obstet Res Open J. 2015; 2(3): e6-e8. doi: 10.17140/GOROJ-2-e003
4. Parasar P. Interactions of immunomodulatory HLA-G with immune cells during pregnancy and endometriosis. Gynecol Obstet Res Open J. 2015; 2(4): 93-95.doi: 10.17140/GOROJ-2-121
Chairman & Assistant Professor
Department of Obstetrics and Gynecology
UT College of Medicine
979 E. Third St., Suite #C-725
Chattanooga, TN 37403, USA
Dr. Lam is board certified in both Ob/Gyn and Maternal-Fetal Medicine. He received his MD from the University of Rochester, completed his residency training at Good Samaritan Medical Center in Phoenix, AZ and went to the University of North Carolina-Chapel Hill for fellowship in Maternal Fetal Medicine. While there, he was trained in various in–utero procedures such as fetal blood sampling and intrauterine transfusion, fetal shunt placement and cord coagulation for parasitic twin gestations. He also participated as the lead obstetrical surgeon or primary assistant for their pilot series of repair of fetal myelomeningocele. Post fellowship, he traveled to Europe to attend the Eurofetus Consortium(Junes annual conferences on Twin Twin Transfusion Syndrome (TTTS), and completed a mini-sabbatical on laser photocoagulation for treatment of TTTS with doctors in both Belgium and the Netherlands. In 2008, along with Dr. William Clewell, he launched the first fetal therapy center in the Southwestern United States: the “Maternal Fetal Center” of Phoenix Perinatal Associates and Banner Good Samaritan Medical Center. He practiced maternal fetal medicine for 8 years in Phoenix, AZ, serving as division director for maternal fetal medicine at Banner Good Samaritan Regional Medical center, and assistant program director for their residency program. His family and he moved to Chattanooga, TN in 2011, where he joined Regional Obstetrical Consultants as Assistant Director for Perinatal Services, and was named Associate Professor at the medical school.
Dr. Lam is a Fellow of the American College of Obstetrics and Gynecology, member of the Society for Maternal Fetal Medicine, International Society for the Study of Hypertension in Pregnancy, International Fetal Medicine and Surgery Society, American Institute of Ultrasound in Medicine, and was a representative to the North American Fetal Therapy Network. He assists the Preeclampsia Foundation with their “Ask the Experts” panel. As a thought leader in obstetrics, he serves on advisory panels and speakers(June boards for various companies in the medical industry.
In 2008, he was presented with the Ob/Gyn Department award for Outstanding Teaching Member of the faculty, and in June 2011, was recognized with a special award for his contributions to resident research and education. Starting in 2008, he has been recognized by his peers each year, with the “Best Doctors in America” award. In June 2013, he was awarded an ACOG National Teaching Award, and in November 2013, was appointed permanent chair of the OB/Gyn department for the University Of Tennessee School Of Medicine in Chattanooga, TN.
Dr. Lam has a deep interest in researching preeclampsia and postpartum hemorrhage. His work on the role of suppressor proteins in preeclamptic mothers has been published in the American Journal of Obstetrics and Gynecology. He has presented multiple abstracts for the International Society for the Study of Hypertension in Pregnancy, and has contributed to the postproduction modifications for a medical device used to treat postpartum hemorrhage. He is primary investigator for multiple local and national studies, and has published articles in multiple national and international medical journals, including AJOG, JSGI, Obstetrics and Gynecology, Obstetrics and Gynecology Survey, and the American Journal of Perinatology. He has contributed chapters to 5 different textbooks. Outside of his professional life, he is devoted to spending as much time as possible with his wife and 3 boys, practicing martial arts and attempting to resuscitate his golf game.
His research interests include: Obstetrics & Gynecology, Maternal & Fetal Medicine.
HONORS AND AWARDS
• 1989, Cynthia Cox Awardee: most outstanding sophomore
• 1989-1991, Achievement Rewards for College Scientists Foundation Scholar (three times)
• 1990-1991, W.M. Keck Foundation Scholar (two times)
• 1990, Los Angeles Philanthropical Society Scholar
• 1990, UCLA Microbiology and Immunology Summer Research Grant
• 1991, MacKenzie Foundation Scholar for pre-meds
• 1991, Thomas J. Watson Fellowship national finalist
• 1991, Mortar Board Honorary Society
• 1991, Phi Beta Kappa
• 1991, Graduated Cum Laude with Honors in Biology and Graduation with Distinction in Religious Studies
• 1992-1995, Koch Scholar
• 1992-1996, Rice Scholar
• 1992-1996, Rochester Prize Scholarship
• 1992-1994, Bradford Scholarship
• 1993, Society for Pediatric Research Summer Fellowship
• 1993, Harvard Medical School Joint Program in Neonatology Research Grant
• 1994, Strong Memorial Hospital Children’s Research Center Grant
• 2001, Awardee: National Vision Grant from the Pre-eclampsia Foundation, for the “Prospective Study to Evaluate the Role of CD3-zeta Expression in Preeclampsia Compared to Normotensive Pregnant Controls”.
1. Martin G, Hose J, Lam G, et al. Organization of Hematopoietic tissue in the Intermolt Lobster. Journal of Morphology. 1993; 216: 65-78. doi: 10.1002/jmor.1052160108
2. Lam G, Stafford R, Thorp JM, Moise KJ, Cairns BC. Use of Nitric Oxide for Primary Pulmonary Hypertension in Pregnancy. Obstet Gynecol. 2001; 98: 895-898.
3. Lam G, Kuller J, McMahon M. Efficacy of MRI and Ultrasound for the Antenatal Diagnosis of Placenta Accreta. J SocGynecolInvestig. 2002; 9: 8-12.
4. Gercel-Taylor C, OConnor S, Lam G, Taylor DD. Shed Membrane Fragment Modulation of CD-3 Zeta during Pregnancy: Link with Induction of Apoptosis. J ReprodImmunol. 2002; 56:29-44. doi: http://dx.doi.org/10.1016/S0165-0378(02)00025-6
5. Lam G, Orton S, Subramanyam L, Farb R, Moise KJ. Minimizing Red Cell Contamination while Isolating Mononuclear Cells from Whole Blood – Next Step to Maternal Alloimmunization with Paternal Mononuclear Cells for the Treatment of Severe Hemolytic Disease of the Newborn. Am J Ob Gyn. 2003; 189: 1012-1016. doi: http://dx.doi.org/10.1067/S0002-9378(03)00813-5
6. Lam G, Whitecar PW, Orton S, Boggess K, Taylor DD. Evidence for Altered Immunoregulation in Preeclampsia. Am J Ob Gyn. 2003; 189: 843-847.
7. Sarsam S, Elliott J, Lam G. Management of Wound Complications from Cesarean Delivery. Obstet Gynec Surv. 2005; 60: 7-18.
8. Lam G, Johnson D, Robinson C, et al. Antepartum administration of digoxin immune Fab (Digibind) improves renal function in subjects with severe preeclampsia. Hypertens Pregnancy. 2008; 27(4): 422.
9. Adair CD, Buckalew VM, Graves SW, et al. Digoxin Immune Fab Treatment for Severe Preeclampsia. Am J Perinatol. 2010; 27(8): 655-662. doi: 10.1055/s-0030-1249762
10. Dildy GA, Belfort MA, Adair CD, et al. Initial Experience with a Dual-Balloon Catheter for the Management of Postpartum Hemorrhage. Am J ObstetGynecol. 2014; 210(2): 136: e1-e6. doi: 10.1016/j.ajog.2013.09.015
Department of Obstetrics and Gynecology
University of Tennessee College of Medicine
979 East Third Street, Suite C-725
Chattanooga, TN 37403, USA
Dr. Akinlaja is presently an Assistant Professor of Obstetrics and Gynecology at the University of Tennessee College of Medicine at Chattanooga and an attending Physician with UT-Erlanger Womens Health Specialists in Chattanooga, Tennessee. He received his medical education at Obafemi Awolowo University College of Health Sciences in Ile-Ife, Nigeria and thereafter completed an OBGYN residency at the Lagos University Teaching Hospital with an award of a fellowship of the West African College of Surgeons. He also completed residency training at Bronx Lebanon Hospital under the aegis of the Albert Einstein College of Medicine, NY. He is Board certified by the American Board of Obstetrics and Gynecology and a fellow of the American College of Obstetrics and Gynecology.
His Research interests include abnormal uterine bleeding, uterine fibroids, minimal invasive surgery, contraception, sexual dysfunction and preterm labor.
Honors and awards include Medical Student Teaching Awards from Albert Einstein College of medicine, NY.
His research interest include: Obstetrics and Gynecology.
Honors and Awards
• FACOG-Fellow of American College of Obstetricians and Gynecologists.
• Board certification, American board of Obstetrics and gynecology, Dec 2009.
• Award for excellence, competence, dedication and outstanding service in the Dept. of OBGYN, Bronx Lebanon Hospital graduating class of 2008.
• FWACS-Fellow of West African College of Surgeons. Jan 2007.
• Best OBGYN resident award, Bronx Lebanon Hospital. Dec 2006
• Award of excellence in medical student teaching. Albert Einstein College of medicine 2004, 2005, 2006 and 2007.
• Certificate of Merit and service, Lagos University teaching hospital, association of resident doctors-2001, 2002 and 2003.
• Certificate of Meritorious performance, National youth service corps, Nigeria-1997.
• Member, American Medical Association.
• Fellowship, American college of Obstetricians and gynecologists.
• (2006-present): Member, American association of gynecological laparoscopists.
1. Akinlaja OA. Postcoital Vaginal Vault Dehiscence- 4 months Post Total laparoscopic Hysterectomy. Austin J Obstet Gynecol. 2014; 1(2): 2. doi: http://dx.doi.org/10.1016/j.jmig.2014.08.517
2. Sherrow S, Akinlaja O, Shaker M. Endometrioma of the Vulva after Episiotomy- a Case Report. Austin J Obstet Gynecol. 2014; 1(4): 1.
3. Yoon AJ, Song J, Megalla S, et al. Left Ventricular Torsional Mechanics in Uncomplicated Pregnancy. Clinical Cardiology. 2011; 34(9): 543-548. doi: 10.1002/clc.20942.
4. Akinlaja O, Anorlu R. Outcome of Labor in Twin Gestation at a Tertiary Institution in a Developing Nation : A 15-year Review. Obstet Gynecol Cases Rev. 2014; 1: 001.
5. Feng AB, Muppuri S, Akinlaja OA, et al. Predictors of Admission to Intensive care unit and outcomes among Obstetric patients in an inner city Hospital: A case control study. ACOCP Chest. 2008; 134(4): p125001. doi: 10.1378/chest.134.4_MeetingAbstracts.p125001
6. Akinlaja OA, Anorlu RI. Knowledge of cervical cancer, awareness and attitude to screening among patients at a cytology clinic. Austin J. Obstet Gynecol. 2014; (1): 4.
7. Akinlaja O, Sherrow S. Postablation Tubal Sterilization Syndrome- a Case Report. Austin J Obstet Gynecol. 2014; 1(1): 2.
8. Akinlaja OA. Ectopic gestation a month after Abdominoplasty. A case report on Laparoscopic management. Journal of minimally invasive Gynecology. 14(6): S109.
9. Akinlaja OA. Ectopic pregnancy with three prior Cesarean deliveries. A case report on Laparoscopic management. Journal of minimally invasive Gynecology. 14(6): S109-S110.
10. Simons M, Ebrahimi H, Sedlacek L, et al. Cytology Cervical intraepithelial Abnormalities in an Inner-City minority adolescent population. Obstetrics and Gynecology. 2008; 11(4): 1S-113S.
11. Akinlaja O. Nausea and vomiting in pregnancy-the bump in the road of motherhood. Gynecol Obstet Res Open J. 2015; 2(4): 85-88. doi: 10.17140/GOROJ-2-119
Assistant Professor of Urology
Department of Urology
Weill Cornell Medical College
New York Presbyterian Hospital
425 East 61st Street, 12th Floor
New York, NY 10065, USA
Weill Cornell Medical Center is pleased to introduce Dr. Chughtai as an Assistant Professor of Urology. Dr. Chughtai specializes in Voiding Dysfunction, Female Urology, and Neurourology.
Dr. Chughtai treats the body as a cohesive system with a focus on Urological care. As such, it’s just as important to address the immediate symptoms as it is to examine the underlying causes of the Urological complaint. Dr. Chughtai engages his patients in a manner that improves their present Urological needs as well as actively involves them in their future wellbeing. His treatment focuses on introducing daily healthy habits and hones in on preventing future Urological conditions. The effectiveness of his medical and surgical treatment relies heavily on strong doctor/patient relationships and on the patient’s resolve to make healthy changes. As his patient, you are promised a passionate and supportive partnership to understand your Urological condition.
Prior to his arrival, Dr. Chughtai completed his Residency in General Surgery and Urology at Albany Medical Center, followed by a Fellowship in Female Urology, Neurourology, and Voiding Dysfunction at Weill Cornell Medical Center and Memorial Sloan Kettering Cancer Center. He earned his Doctor of Medicine at State University of New York at Stony Brook after graduating Magna cum Laude from New York University with a major in Biological Sciences.
Dr. Chughtai is also an active researcher. He has served as primary & co-investigator in numerous studies. He has also published over 70 peer-reviewed articles, authored chapters and books, and has presented at numerous prestigious national meetings.
Dr. Chughtai maintains a successful Urological practice in both men and women. If you are interested in a consultation with Dr. Chughtai, please call to set up an appointment at (646) 962-4811.
His research interests include: Urology, Urogynecology, General Urology.
• National Association for Continence, Project Advisory Council, 2012 - present
• Catheter Associated UTI Committee, Committee Member, 2013 – present
• (June 2005 – present): Member American Urological Association
• (July 2010 - present): Associate Faculty Member of Faculty of 1000
• (July 2012 - present): National Association for Continence, Project Advisory Council
• (July 2013 - present): Member of NY Section AUA
• (July 2013 - present): Member of SUFU
1. Jarvis T, Chughtai B, Kaplan S. Testosterone and benign prostatic hyperplasia. Asian Journal of Andrology. 2014; 16: 1-5. doi: 10.4103/1008-682X.140966
2. Chughtai B, Kaplan SA. Surgical Treatment of Benign Prostatic Hyperplasia. Urology Practice. 2014; 45-48. doi: http://dx.doi.org/10.1016/j.urpr.2014.02.007
3. Otto B, Barbieri C, Lee R, et al. Incidental Prostate Cancer in Transurethral Resection of the Prostate Specimens in the Modern Era. Advances in Urology. 2014; 2014: 627290. doi: 10.1155/2014/627290
4. Laudano M, Jamzadeh A, Dunphy C, et al. Pathologic Outcomes following Urethral Diverticulectomy in Women. Advances in Urology, 2014; 2014: 861940. doi: 10.1155/2014/861940
5. Weissbart S, Coutinho K, Elterman D, Chughtai B. New Medical and Injectable Treatments for LUTS/ BPH – Anticholinergics, PDE-5, and Botox. Curr Bladder Dysfunct Rep. 2014; 9: 114–121. doi: 10.1007/s11884-014-0227-x
6. Blankstein U, Chughtai B, Elterman D. Relationship Between the Metabolic Syndrome and BPH-Related Voiding Dysfunction. Curr Bladder Dysfunct Rep 2014; 9: 122–128. doi: 10.1007/s11884-014-0230-2
7. Elterman DS, Chughtai B. Alpha-blocker and apoptosis. Cent European J Urol. 2013; 662: 195. doi: 10.5173/ceju.2013.02.art20.
8. Chughtai B, Elterman D, Vertosick E, Maschino A, Eastham JA, Sandhu JS. Changes in Pelvic Organ Prolapse Surgery in the Last Decade among United States Urologists. J Urol. 2013; 191(4): 1022-1027 doi: 10.1016/j.juro.2013.10.076.
9. Elterman DS, Chughtai B, Lee R, Te AE, Kaplan SA. Re: Noninvasive methods to evaluate bladder obstruction in men Int Braz J Urol. 2013; 395: 758-759. doi: http://dx.doi.org/10.1590/S1677-5538.IBJU.2013.01.02
10. Hueber PA, Liberman D, Ben-Zvi T, et al. 180 W vs 120 W Lithium TriboratePhotoselective Vaporization of the Prostate for Benign Prostatic Hyperplasia: A Global, Multicenter Comparative Analysis of Perioperative Treatment Parameters. Urology. 2013; 825: 1108-1113. doi: 10.1016/j.urology.2013.03.059
11. Chughtai B, Kavaler E, Lee R, Te A, Kaplan SA, Lowe F. Use of herbal supplements for overactive bladder. Rev Urol. 2013; 153: 93-96.
12. Elterman DS, Chughtai B, Kaplan SA, Barkin J. Tolterodine for the treatment of urge urinary incontinence. Expert Opin Pharmacother. 2013; 1414: 1987-1991. doi: 10.1517/14656566.2013.823158
13. Elterman D, Chughtai B. Long-term Outcomes Following Abdominal Sacrocolpopexy for Pelvic Organ Prolapse. Urology. 2013; 824: 757-758.
14. Chughtai B, Lee R, Sandhu J, Te A, Kaplan S. Conservative treatment for postprostatectomy incontinence. Rev Urol. 2013; 152: 61-66. doi: 10.1001/jama.2010.1972.
15. Seklehner S, Laudano MA, Te AE, Kaplan SA, Chughtai B, Lee RK. A cost-effectiveness analysis of retropubicmidurethral sling versus transobturatormidurethral sling for female stress urinary incontinence. NeurourolUrodyn. 2013 . doi: 10.1002/nau.22483
16. Seklehner S, Laudano MA, Chughtai B, et al. Trends in the utilization of percutaneous and open nephrolithotomy in the treatment of renal calculi. J Endourol. 2013; 278: 984-988. doi: 10.1089/end.2013.0112.
17. Jamzadeh AE, Xie D, Laudano M, et al. Urodynamic characterization of lower urinary tract symptoms in men less than 40 years of age. World J Urol. 2013. doi: 10.1007/s00345-013-1134-z
18. Seklehner S, Laudano MA, Jamzadeh A, Del Pizzo JJ, Chughtai B, Lee RK. Trends and Inequalities in the Surgical Management of Ureteral Calculi in the United States. BJU Int. 2013. doi: 10.1111/bju.12372.
19. Laudano MA, Seklehner S, Chughtai B, et al. Cost-effectiveness analysis of tension-free vaginal tape vs burchcolposuspension for female stress urinary incontinence in the USA. BJU Int. 2013; 1122: E151-E158. doi: 10.1111/bju.12180.
20. Chughtai B, Kaplan SA. Medical and Surgical Management of Bladder Outlet Obstruction. Renal and Urology News. 2013.
21. Weissbart S, Chughtai B, Elterman D, Sandhu J. Management of Anastomotic Stricture afterArtificial Urinary Sphincter Placement in Patients Who Underwent Salvage Prostatectomy. Urology. 2013. doi: 10.1016/j.urology.2013.03.012
22. Chughtai B, Lee RK, Elterman DS, et al. Comparison of 80 W versus 120 W 532 nm Laser Prostatectomy for BPH. Open Journal of Urology. 2013.
23. Chughtai B, Laudano MA, Lee RK, et al. Use of the bulbocavernosus reflex system in assessing voiding dysfunction. World J Urol. 2013. doi: 10.1007/s00345-013-1063-x
24. Chughtai B, Te AE. BPH in 2012: Novel agents in treatment of BPH. Nat Rev Urol. 2013; 10: 72-73. doi: 10.1038/nrurol.2012.250.
25. Chughtai B, Elterman DS, Lee RK, Te AE, Kaplan SA. Non-invasive methods to diagnose bladder outlet obstruction in men. International Brazilian Journal of Urology. 2012; 38: 512-517. doi: http://dx.doi.org/10.1016/S0022-5347(06)00570-2
26. Xie D, Chughtai B, Elterman D, et al. The Link between Benign Prostatic Hyperplasia and Sexual Dysfunction. Curr Bladder Dys funct Rep. 2013. doi: 10.1007/s11884-013-0187-6
27. Chughtai B, Te AE. Update on BPH Therapy. AUA News. 18(1): 9-13. 28. Chughtai B, Elterman D, Lee R, Te A, Kaplan SA. Experience with the combination of dutasteride and tamsulosin in the long-term management of benign prostatic hyperplasia. Ther Adv Urol. 2012; 00: 1– 6. doi: 10.1177/1756287212457115
29. Elterman DS, Chughtai B, Sandhu JS. Treatment options for male stress urinary incontinence. European Urological Review 2012; 72: 127-131. doi: 10.1038/nrurol.2010.26.
30. Chughtai B, Lee R, Te AE, Kaplan SA. Combination therapy in themanagement of LUTS – is thisthe future? Drug Discovery Today: Therapeutic Strategies. 2012; 9(1): 1740-1744. doi: 10.1016/j.ddstr.2012.03.001
31. Chughtai B, Elterman DS, Lee R, Te AE, Kaplan SA. Experience with the combination of dutasteride and tamsulosin in the long-term management of benign prostatic hyperplasia. Ther Adv Urol. 2012; 45: 267-272. doi: 10.1177/1756287212457115
32. Weissbart S, Chughtai B, Elterman DS, Lee RK, Te AE, Kaplan SA. Acetylcholine for male LUTS. Current Urology Rep. 2012; 136: 413-419. doi: 10.1007/s11934-012-0276-7.
33. Tewari AK, Ali A, Ghareeb G, et al. Improving time to continence after robot-assisted laparoscopic prostatectomy: augmentation of the total anatomic reconstruction technique by adding dynamic detrusor cuff trigonoplasty and suprapubic tube placement. J Endourol. 2012; 2612: 1546-1552. doi: 10.1089/end.2012.0544.
34. Matsushita K, Chughtai B, Maschino AC, Lee RK, Sandhu JS. International variation in artificial urinary sphincter use. Urology. 2012; 803: 667-672. doi: 10.1016/j.urology.2012.04.065
35. Green DA, Rink M, Cha EK, et al. Cost Effective treatment of low-risk carcinoma not invading bladder muscle. BJU Int. 2012. doi: 10.1111/j.1464-410X.2012.11454.x
36. Spettel S, Chughtai B, Feustel P, Kaufman A, Levin RM, De E. A prospective randomized double-blind trial of grape juice antioxidants in men with lower urinary tract symptoms. Neurourol Urodyn. 2012. doi: 10.1002/nau.22289
37. Chughtai B, Sheth S, Lee R, Tyagi R, Kavaler E. The use of synthetic mesh and the management of mesh extrusion in vaginal surgery. Expert Review Med Devices. 2012; 94: 437-442. doi: 10.1586/erd.12.20.
38. Srivastava A , Chopra S, Pham A, et al. Effect of a Risk-stratified Grade of Nerve-sparing Technique on Early Return of Continence After Robot-assisted Laparoscopic Radical Prostatectomy. European Urology. 2012; 10: 1016. doi: 10.1016/j.eururo.2012.07.009
39. Matsushita K, Ginsburg L, Mian B, et al. Pubovesical Fistula: A Rare Complication After Treatment of Prostate Cancer. Urology. 2012 . doi: 10.1016/j.urology.2012.04.036.
40. Lee R, Chughtai B, Te AE, Kaplan SA. Sexual function in men with metabolic syndrome. Urol Clin North Am. 2012; 391: 53-62. doi: 10.1016/j.ucl.2011.09.008.
41. Lee RK, Chung D, Chughtai B, Te AE, Kaplan SA. Central obesity as measured by waist circumference is predictive of severity of lower urinary tract symptoms. BJU Int. 2012; 1104: 540-545.
42. Chughtai B, Lee RK, Te AE, Kaplan SA. Metabolic syndrome and sexual dysfunction. Curr Opin Urol. 2011; 216: 514-518. doi: 10.1097/MOU.0b013e32834b8681.
43. Blaivas J, Chughtai B, Tsui J, Laudano M. Management of Bladder Diverticula. Current Bladder Dysfunction Report. 2011; 6: 198-210.
44. Lee R, Chughtai B, Herman M, Shariat SF, Scherr DS. Cost-analysis comparison of robot-assisted laparoscopic radical cystectomy RC; vs open RC. BJU Int. 2011; 1086(2): 976-983. doi: 10.1111/j.1464-410X.2011.10468.x
45. Chughtai B, Lee R, Te A, Kaplan SA. Role of inflammation in benign prostatic hyperplasia. Rev Urology 2011; 123: 147-150.
46. Chughtai B, Te A. Photoselective vaporization of the prostate for treating benign prostatic hyperplasia. Expert Rev Med Devices. 2011; 85: 591-595. doi: 10.1586/erd.11.25.
47. Chughtai B, Sandhu J. Surgical Management of Post Prostatectomy Incontinence. Arab Health. 2011; 2: 42-44.
48. Chughtai B, Sandhu J. Take Home Message: BPH/LUTS AUA 2011. AUA News. 2011; 16(7): 10-11.
49. Chughtai B, Lee R, Te A, Kaplan S. Inflammation and Benign Prostatic Hyperplasia: Clinical Implications. Curr Urol Rep. 2011. doi: 10.1007/s11934-011-0191-3
50. Chughtai B, Sandhu J. Incontinence: Conservative treatment of postprostatectomy incontinence. Nature Rev Urology. 2011. doi:
51. Pentyala S, Jalali S, Park J, et al. Urologic Problems in Multiple Sclerosis. The Open Andrology Journal. 2010; 2: 37-41.
52. Chughtai B, Sciullo D, Khan S, Rehman R, Mohan E, RehmanJ. Etiology, Diagnosis & Management of Hypersexuality: A Review. The Internet Journal of Urology. 2010; 6: 2.
53. Chughtai B, Sciullo D, Khan S, Rehman R, Mohan E, Rehman J. In-Situ Catheterizable Bladder Tube withSubmucosal Tunneling Catherizable Channel as Continent Mechanism For Urinary Diversion: A Technique. The Internet Journal of Urology. 2010; 6: 2.
54. Chughtai B, Sciullo D, Khan S, Rehman R, Mohan E, Rehman J. Ultrasound Guided Peri-Prostatic Neurovascular Infiltration For Biopsy And Minimally Invasive Prostate Surgery. The Internet Journal of Urology. 2010; 6: 2.
55. Chughtai B, Samadi D, Guru K, Frischer Z, Rehman J. Granulocytic sarcoma of the adrenal gland. Canadian Journal of Urology. 2009; 164: 4760-4761.
56. Rehman J, Chughtai B, Guru K, Shabsigh R, Samadi DB. Management of an enlarged median lobe with ureteral orifices at the margin of bladder neck during robotic-assisted laparoscopic prostatectomy. Canadian Journal of Urology. 2009; 161: 4490-4494.
57. Chughtai B, Mian BM. High risk prostate cancer: evolving definition and approach to management. Canadian Journal of Urology. 2008; 156: 4375-4380.
58. Rehman J, Chughtai B, Guru K, Khan S, Adler H, Miller F. Wilms Tumor during Pregnancy: Case Report of Laparoscopic Removal and Review of Literature. Canadian Journal of Urology 2008; 154: 4180-4183.
59. Samadi D, Chughtai B, Akhavan A, Guru K, Rehman J. Incidental Seminal Vesicle Smooth Muscle Neoplasm of Unknown Malignancy Following Robotic Assisted Laparoscopic Prostatectomy. Canadian Journal of Urology. 2008; 153: 4109-4111.
60. Rehman J, Guru K, Chughtai B, Shabsigh R, Samadi D. Robotic Radical Prostatectomy in Patients with Preexisting Inflatable Penile Prosthesis IPP. Canadian Journal of Urology. 2008; 155: 4263-4265.
61. Rehman J, Chughtai B, Guru K, Samadi D, Khan S. Laparoscopic Extravesical Ureteroneocystostomy by a New Y Flap Technique. Journal of Endourology. 2008; 228: 1701-1703. doi: 10.1089/end.2007.0346.
62. Chughtai B, Abraham C, Finn D, Rosenberg S, Yarlagadda B, Perrotti M. Fast Track Open Partial Nephrectomy: Reduced Post Operative Length of Stay with a Goal Directed Pathway Does Not Compromise Outcome. Advances in Urology. 2008. doi: 10.1155/2008/507543.
63. Chughtai B, De E, Levin R. Choice of Anti-Muscarinic Agents for Overactive Bladder in the Older Patient- Focus on Darifenacin. Clinical Interventions in Aging. 2008; 33: 503-509. doi: http://dx.doi.org/10.2147/CIA.S3414
64. Rehman J, Yildirim G, Khan SA, Chughtai B, Nezhat F. A Case of Successful Laparoscopic Resection of Adrenal Gland Endometriosis. Fertility and Sterility. 2008; 905: e7-e9. doi: 10.1016/j.fertnstert.2008.01.006
65. Rehman J, Chughtai B, Schulsinger D, Adler H, Khan SA, Samadi D. A Percutaneous Subcostal Approach to the Intercostal Stone: A Technique. Journal of Endourology. 2008; 223: 497-502. doi: 10.1089/end.2007.0263.
66. Rehman J, Chughtai B, Sukkarich T, Khan SA. Extraperitoneal Laparoscopic Removal of Eroded Mid-Urethral Sling: A New Technique. Journal of Endourology. 2008; 222: 365-368. doi: 10.1089/end.2007.0008
67. Levin RM, Chughtai B, Mannikarottu A, et al. Ischemic Etiology of Incontinence in Women: A Theory and a Review. The Open Urology & Nephrology Journal. 2008; 1(1): 1-8.
68. Rehman J, Boglia J, Chughtai B, et al. High Body Mass Index in Muscular Patients and Flank Position are Risk Factors for Rhabdomyolysis: Case Report after Laparoscopic Live-Donor Nephrectomy. Journal of Endourology. 2006; 209: 646-650. doi: 10.1089/end.2006.20.646.
69. Rehman J, Khan S, Sukkarieh T, Chughtai B, Samadi D, Waltzer W. Extraperitoneal Laparoscopic Prostatectomy for Obstructing Benign Prostatic Hyperplasia: Transvesical and Transcapsular Millin; Techniques. Journal of Endourology. 2005; 194: 491-496. doi: 10.1089/end.2005.19.491.
70. Malley R, Chughtai B, Sukkarieh T, et al. Case and Management of Incidentalomas in Patients with Von Hippel-Lindau Disease. Urologica Internationalis. 2005; 752: 189-191. doi: 10.1159/000087178
71. Rehman J, Rizkala ER, Chughtai B, Khan SA. Hypoechoic Testicular Mass: A Case of Testicular and Epididymal Sarcoidosis. Urology. 2005; 663: 657. doi: http://dx.doi.org/10.1016/j.urology.2005.03.008
72. Chughtai B, Sawas A, O Malley R, Pentyala S, Khan S. A Neglected Gland: A Review of Cowpers Gland. International Journal of Andrology. 2005; 282: 74-77. doi: 10.1111/j.1365-2605.2005.00499.x
73. Riordan T, Seischab LB, Ying Q, et al. Antiprotease Function of Airway Secretions in Purulent Tracheobronchitis. Chest. 2005; 1285: 3167-3176. doi:
74. Rehman J, Ragab M, Venkatesh R, et al. Smooth Muscle Regeneration after Electrosurgical Endopyelotomy in a Porcine Model as Confirmed by Electron Microscopy. Journal of Endourology. 2004; 1810: 982-988. doi: 10.1378/chest.128.5.3167
75. Chughtai B, O Riordan T. Potential Role of Inhibitors of Neutrophil Elastase In Treating Diseases Of The Airway. Journal of Aerosol Medicine. 2004; 174: 289-298. doi: 10.1089/jam.2004.17.289.
Research Assistant Professor
Department of Obstetrics and Gynaecology
The Chinese University of Hong Kong
Tai Po Road, Sha Tin
New Territories, Hong Kong
• 2005-2008: Ph.D Department of Obstetrics & Gynaecology, The Chinese University of Hong Kong, Hong Kong
• 2001-2004: M.Sc Department of Biochemistry & Molecular Biology, Nankai University, Tianjin, P.R. China
• 1996-2000: B.Sc. Department of Biology, Liaoning University, Liaoning, P.R. China
• 2013.04 - Present: Research Assistant Professor, Department of Obstetrics & Gynaecology, The Chinese University of Hong Kong
• 2011.08 - 2013.04: Research Assistant, Department of Obstetrics & Gynaecology, The Chinese University of Hong Kong
• 2010.07 - 2011.07: Research Assistant, Department of Orthopaedics & Traumatology, The Chinese University of Hong Kong
• 2009.07 - 2010.07: Post Doctorial Fellow, Department of Orthopaedics & Traumatology, The Chinese University of Hong Kong
• 2009.01 - 2009.07: Research Assistant, Department of Orthopaedics & Traumatology, The Chinese University of Hong Kong
• 2004.09 - 2005.06: Manager, Tianjin walkman biomaterial CO., LTD. in Tianjin, P.R. China
His research interests include: Cervical cancer, RNAi based cancer therapy strategy.
MEMBERSHIPS IN PROFESSIONAL SOCIETIES
• 2011 - Present: The Hong Kong Society of Medical Genetics (HKSMG)
• 2010 - Present: International Chinese Hard Tissue Society
• 2007 - 2008: American Association for Cancer Research
EDITORIAL BOARD MEMBER
• 2013 - Present: editor for Medical Journal of Obstetrics and Gynecology
• 2014 - Present: editor for Austin Journal of Obstetrics and Gynecology
• 2014 - Present: eminent editor for Journal of Andrology & Gynaecology
• 2014 - Present: associate editor of International Journal of Medical Therapy & Therapeutics
• 2014 - Present: Reviewer in Cancer Research Frontiers
1. Deng Y, Wang CC, Choy KW, et al. Therapeutic potentials of gene silencing by RNA interference: Principles, challenges, and new strategies. Gene. 2014; 538: 217-227. doi: 10.1016/j.gene.2013.12.019.
2. Guo B, Zhang B, Zheng L, et al. Therapeutic RNA interference targeting CKIP-1 with a cross-species sequence to stimulate bone formation. Bone. 2014; 59: 76-88. doi: 10.1016/j.bone.2013.11.007.
3. Chen S, Lau P, Lei M, et al. Segmental composite porous scaffolds with either osteogenesis or anti-bone resorption properties tested in a rabbit ulna defect model. Journal of Tissue Engineering and Regenerative Medicine. 2013. doi: 10.1002/term.1828.
4. Yan L, Raphael AP, Zhu X, et al. Nanocomposite-Strengthened Dissolving Microneedles for Improved Transdermal Delivery to Human Skin. Adv Healthc Mater. 2013. doi: 10.1002/adhm.201300312.
5. Tang T, Wong HK, Gu W, et al. MicroRNA-182 plays an onco-miRNA role in cervical cancer. Gynecol Oncol. 2013; 129: 199-208. doi: 10.1016/j.ygyno.2012.12.043.
6. Wang X, Guo B, Li Q, et al. miR-214 targets ATF4 to inhibit bone formation. Nat Med. 2012. doi: 10.1038/nm.3026.
7. Zhang G, Guo B, Wu H, et al. A delivery system targeting bone formation surfaces to facilitate RNAi-based anabolic therapy. Nat Med. 2012; 18(2): 307-314. doi: 10.1038/nm.2617.
8. He YX, Liu Z, Pan XH, et al. Deletion of estrogen receptor beta accelerates early stage of bone healing in a mouse osteotomy model. Osteoporos Int. 2012; 23(1): 377-389. doi: 10.1007/s00198-011-1812-x.
9. Tang T, Zhang G, Carol Lau PY, et al. Effect of water soluble P-chitosan and S-chitosan on human primary osteoblasts and giant cell tumor of bone stromal cells. Biomed Mater. 2011; 6(1): 015004. doi: 10.1088/1748-6041/6/1/015004.
10. Chan SY, Choy KW, Tsao SW, et al. Authentication of nasopharyngeal carcinoma tumor lines. Int J Cancer. 2008; 122(9): 2169-2171. doi: 10.1002/ijc.23374.
Associate Professor and Director of Ovarian Screening Research Program
UK Gynecologic Oncology
Markey Cancer Center
University of Kentucky
331 E. Whitney-Hendrickson Womens Cancer Facility
800 Rose St., Lexington, KY 40536-0293, USA
Dr. Pavlik is a graduate of the University of Denver, and received his PhD from the University of Tennessee, Knoxville. He received a NCI Public Health Service Fellowship at the University of Illinois, Champaign-Urbana, Illinois and was a Visiting Assistant Professor, Department of Physiology and Biophysics at the University of Illinois, Champaign-Urbana. He is an active lecturer in the College of Medicine and organizes and mentors summer intern research including students from Denison University, Penn State University, Transylvania University, Centre College, Vassar College, the University of North Carolina, Eastern Kentucky University and the University of Kentucky. He is a member of the Graduate College and serves on dissertation committees for the PhD degree. Dr. Pavlik is an author on over 100 peer reviewed publications, has presented at a number of prestigious international conferences, and has been funded by the NCI, the ACS and the VA. His research focus is on ovarian cancer screening and factors that affect screening accuracy and performance.
His research interests include: Ovarian cancer, cancer screening, tumor imaging.
AWARDS AND HONORS
• Keynote speaker - 4th Annual Advances in Gynaecological Oncology, The Royal Prince Albert Hospital & the Sydney Gynaecologic Oncology Group, Sydney AU, October 19, 2007
PROFESSIONAL ACTIVITY AND PUBLIC SERVICE
• Ad hoc Reviewer Cancer, JAMA, Endocrine
• Journal Editorial Board Member: Journal of Gynecology and Obstetrics, the Journal of Medical Oncology, the Imaging Journal of Clinical and Medical Sciences.
1. Pavlik EJ, Coulson PB. Hydroxylapatite Batch assay for estrogen receptor Increased sensitivity over present assays. J Steroid Biochem. 1976; 7: 357-368.
2. Pavlik EJ, Coulson PB. Modulation of estrogen receptors in four different target tissues: Differential effects of estrogen and progesterone. J Steroid Biochem. 1976; 7: 369-376. doi: 10.1016/0022-4731(76)90096-0
3. Hill JO, Pavlik EJ, Smith GL, Burghardt GM, Coulson PB. Species-characteristic response to catnip by undomesticated felids. J Chem Ecol. 1976; 2: 239-253. doi: 10.1007/BF00987747
4. Coulson PB, Pavlik EJ. Effects of estrogen and progesterone on cytoplasmic estrogen receptor and rates of protein synthesis in rat uterus. J Steroid Biochem. 1977; 8: 205-212. doi: 10.1016/0022-4731(77)90052-8
5. Pavlik EJ, Katzenellenbogen BS. Human endometrial cells in primary tissue culture: Estrogen interactions and modulation of cell proliferation. J Clin Endocrinol and Metab. 1978; 47: 333-343. doi: http://dx.doi.org/10.1210/jcem-47-2-333
6. Pavlik EJ, Rutledge S, Eckert R, Katzenellenbogen BS. Localization of estrogen-receptors in the nucleus: An appraisal of translocation. Experimental Cell Res. 1979; 123: 177-189. doi: 10.1016/0014-4827(79)90434-8
7. Pavlik EJ, Katzenellenbogen BS. The stability of the uterine estrogen receptor when complexed with estrogens or antiestrogens. Molecular Pharmacology. 1980; 18: 406-412.
8. Pavlik EJ, Rutledge S. Estrogen-binding properties of cytoplasmic and nuclear estrogen receptors in the presence of Triton X-100: Differences between cytoplasmic and nuclear receptors. J Steroid Biochem. 1980; 13: 1433-1441.
9. Katzenellenbogen BS, Pavlik EJ, Robertson DW, Katzenellenbogen JA. Interaction of a high affinity antiestrogen(4-pyrrolidinoethocy) phenyl-4-hydroxy-nitrostilbene, CI628M) with uterine estrogen receptors. J Biol Chem. 1981; 256: 2908-2915.
10. Van Nagell JR, Donaldson ES, Hanson MB, Gay EC, Pavlik EJ. Biochemical markers in the plasma and tumors of patients with gynecologic malignancies. Cancer. 1981; 48: 495-503. doi: 10.1002/1097-0142(19810715)48:1+3.0.CO;2-F
11. Pavlik EJ, Katzenellenbogen BS. The intranuclear distribution of rat uterine estrogen receptors determined after nuclease treatment and chromatin fractionation. Molecular and Cellular Endoc. 1982; 26: 201-216. doi: 10.1016/0303-7207(82)90017-X
12. Pavlik EJ, Van Nagell JR, Hanson MB, Donaldson ES, Powell DE, Kenady DE. Sensitivity to anticancer agents in vitro: Standardizing the cytotoxic response and characterizing the sensitivities of a reference cell line. Gynecologic Oncology. 1982; 14: 243-261. doi: http://dx.doi.org/10.1016/0090-8258(82)90097-X
13. Pavlik EJ, Van Nagell JR, Donaldson ES, Hanson MB. Some practical aspects of the separation of estrogen and progesterone receptors by size exclusion high performance liquid chromatography which are relevant to quantitation. J Steroid Biochem. 1982; 17: 553-558. doi: 10.1016/0022-4731(82)90015-2
14. Pavlik EJ, Kenady DE, Van Nagell JR, et al. Properties of anticancer agents relevant to in vitro determinations of human tumor cell sensitivity. Cancer Chemotherapy Pharmacol. 1983; 11: 8-15. doi: 10.1007/BF00257408
15. Pavlik EJ, Flanigan RC, Van Nagell JR, Swanson, L, Keaton, K, Kenady DE. The effect of different agars, agaroses and methyl cellulose on the in vitro proliferation of a human urinary transitional cell carcinoma cell line. J Urology. 1983; 129: 1254-1257.
16. Pavlik EJ, Kenady DE, Van Nagell JR, Keaton, K, Donaldson ES, Hanson MB, Flanigan RC. The proliferation of human tumor cell lines in the presence of different agars, agaroses and methyl cellulose. In Vitro. 1983; 19: 538-550. doi: 10.1007/BF02619602
17. Pavlik EJ, Kenady DE, Van Nagell JR, et al. The stability of doxorubicin in relation to chemosensitivity determinations: loss of lethality and retention of antiproliferative activity. Cancer Investigation. 1984; 2(6): 449-458. doi: 10.3109/07357908409048518
18. Pavlik EJ, Nelson K, Van Nagell JR, et al. VISICALC and VISIPLOT software routines and the analysis of data routinely encountered in steroid biochemistry. Steroids. 1984; 43: 393-405.
19. Casper, S, Van Nagell JR, Pavlik EJ, et al. Immunohistochemical Localization of tumor markers in epithelial ovarian cancer. Am J Obst & Gyn. 1984; 149: 154-158.
20. Pavlik EJ, Flanigan RC, Van Nagell JR, et al. Esterase activity, exclusion of propidium iodide and proliferation in tumor cells exposed to anticancer agents: phenomena relevant to chemosensitivity determinations. Cancer Investigation. 1985; 3(4): 413-426. doi: 10.3109/07357908509039802
21. Pavlik EJ, Nelson K, Van Nagell JR, et al. Steroid receptor analysis by size exclusion HPLC: considerations for the clinical laboratory. Clinical Chemistry. 1985; 31: 537-545.
22. Hanson MB, Van Nagell JR, Powell DE, et al. The prognostic significance of lymph-vascular space invasion in stage I endometrial cancer. Cancer. 1985; 55: 1753-1757.
23. Flanigan, Robert C, Pavlik EJ, et al. Growth of urinary transitional cell carcinoma cell lines in agar, agarose, and methyl cellulose. J Urology. 1985; 134: 985-990.
24. Pavlik EJ, Flanigan, Robert C, et al. Programming for DNA analysis of FCM data on an IBM microcomputer. Cytometry. 1985; 7: 93-97.
25. Janina B-K, Pavlik EJ, et al. Dichloro(6-aminoethylaminopurine)platinum II and its hydroxy analogues: synthesis and preliminary evaluation. Inorganica Chimica Acta. 1985; 108: 91-98.
26. Pavlik EJ, Van Nagell JR, Nelson K, Gallion H, Donaldson ES, Kenady DE. Antagonism to estradiol in the mouse : Reduced entry of receptors complexed with 3H-4OH-tamoxifen into a Mg-soluble chromatin fraction. Endocrinology. 1986; 118: 1924-1934. doi: http://dx.doi.org/10.1210/endo-118-5-1924
27. Flanigan, R, C, Pavlik EJ, Van Nagell JR, Keaton K, Kenady DE. Proliferation, esterase activity, and propidium iodide exclusion in urologic tumor cells after in vitro exposure to chemotherapeutic agents. J Urology. 1986; 135: 1091-1100.
28. Pavlik EJ, Nelson K, Gallion, H, et al. The effects of treatment with cytotoxic anticancer agents on the capacity for subsequent hormonal responses in the mouse uterus. J Steroid Biochemistry. 1986; 25: 231-237.
29. Cibull ML, Thompson ME, Pavlik EJ, et al. Marked hypodiploidy in blast phase chronic myelogenous leukemia: report of a case and review of the literature. Am J Hematol. 1987; 24: 293-299.
30. Pavlik EJ, Nelson K, Van Nagell JR, et al. Extensive in situ activation of nuclear estrogen receptors after exposure of murine uteri to [3H]-Estradiol or [3H]-4-Hydroxytamoxifen. Endocrinology. 1987; 120: 1608-1614. doi: http://dx.doi.org/10.1210/endo-120-4-1608
31. Baranowska-Kortylewicz J, Nelson K, Pavlik EJ, et al. Identification of a very large nuclear estrogen receptor complex. Endocrinology. 1987; 120: 2189-2191. doi: http://dx.doi.org/10.1210/endo-120-5-2189
32. Nelson K, Van Nagell JR, Gallion HH, Donaldson ES, Pavlik EJ. Estrogens and antiestrogens mediate contrasting transitions in estrogen receptor conformation which determine chromatin access: A review and synthesis of recent observations. Prog Clin Biol Res. 1987; 262: 85-104.
33. Rowley KC, Gallion HH, Donaldson ES, et al. Prognostic factors in early vulvar cancer. Gynecologic Oncology. 1988; 31: 43-49.
34. Van Nagell JR, Powell DE, Gallion HH, et al. Small cell carcinoma of the uterine cervix. Cancer. 1988; 62: 1586-1593.
35. Gallion HH, Van Nagell JR, Powell DF, et al. Stage I Serous Papillary Carcinoma of the Endometrium. Cancer. 1989; 63: 2224-2228.
36. Higgins RV, Van Nagell JR, Donaldson ES, et al. Transvaginal sonography as a screening method for ovarian cancer. Gynecologic Oncology. 1989; 34: 402-406.
37. Higgins RV, Van Nagell JR, Donaldson ES, Gallion HH, Pavlik EJ, Kryscio RJ. The efficacy of laser therapy in the treatment of cervical intraepithelial neoplasia. Gynecologic Oncology. 1990; 36: 79-81. doi: http://dx.doi.org/10.1016/0090-8258(90)90112-X
38. Van Nagell JR, Higgins RV, Donaldson ES, et al. Transvaginal Sonography as a Screening Method for Ovarian Cancer: A Report of the First 1000 Cases Screened. Cancer. 1990; 65: 573-577.
39. Pavlik EJ, Nelson K, Gallion HH, et al. Characterization of High Specific Activity [16alpha-123]Iodo-estradiol 17, beta as an Estrogen Receptor Specific Radioligand Capable of Imaging Estrogen Receptor-Positive Tumors. Cancer Research. 1990; 50: 7799-7805.
40. Higgins RV, Van Nagell JR, Donaldson ES, Gallion HH, Pavlik EJ, Endicott B and Woods CH. Transvaginal sonography as a screening method for ovarian cancer. Maturitas. 1990; 12(1): 75-76.
41. Higgins RV , Van Nagell JR, Donaldson ES , et al. Transvaginal sonography as a screening method for ovarian cancer. International Journal of Gynecology & Obstetrics. 1990; 31(4): 381.
42. Van Nagell JR, DePriest PD, Puls LE, et al. Ovarian Cancer Screening in Asymptomatic Postmenopausal Women by Transvaginal Sonography. Cancer. 1991; 68: 458-462. doi: 3.0.CO;2-3>
43. Pavlik EJ, Nelson K, Van Nagell JR, et al. The growth response of BG-1 ovarian carcinoma cells to estradiol, 40H-tamoxifen and tamoxifen: Evidence for intrinsic antiestrogen activation. Gynecologic Oncology. 1991; 42: 245-249. doi: 10.1016/0090-8258(91)90166-3
44. Pavlik EJ, Nelson K, Srinivasan S, et al. Resistance to tamoxifen with persisting sensitivity to estrogen: Possible mediation by excessive antiestrogen binding site activity. Cancer Research. 1992; 52: 4106-4112.
45. Van Nagell JR, De Priest PD, Gallion HH, Pavlik EJ. Ovarian Cancer Screening. Cancer. 1993; 71: 1523-1528.
46. Puls LE, Davey DD, De Priest PD, et al. Immunohistochemical Staining for CA-125 in Fallopian Tube Carcinomas. Gynecologic Oncology. 1993; 48: 360-363. doi: http://dx.doi.org/10.1006/gyno.1993.1063
47. De Priest PD, Shenson D, Pavlik EJ, et al. A morphology index based on sonographic findings in ovarian cancer. Gynecologic Oncology. 1993; 51: 7-11. doi: http://dx.doi.org/10.1006/gyno.1993.1238
48. DePriest PD, Van Nagell JR, Gallion HH, et al. Ovarian cancer screening in asymptomatic postmenopausal women. Gynecologic Oncology. 1993; 51: 205-209. doi: http://dx.doi.org/10.1006/gyno.1993.1273
49. Kenady DE, Pavlik EJ, Nelson K, et al. Images of estrogen receptor(ERc)--positive breast tumor produced by 16 alpha [123I]-Estradiol. Archives of Surgery. 1993; 128: 1373-1381. doi: 10.1001/archsurg.1993.01420240081016
50. Pavlik EJ, Nelson K, Srinivasan S, et al. The pure antiestrogen ICI-164384 interacts with estrogen receptors and non-estrogen receptor molecules in rodent and human preparations. Endocrine. 1993; 1: 147-155.
51. Pavlik EJ, Van Nagell JR, De Priest PD, et al. Participation in transvaginal ovarian cancer screening: compliance, correlation factors, and costs. Gynecologic Oncol. 1995; 57: 395-400. doi: http://dx.doi.org/10.1006/gyno.1995.1161
52. Van Nagell JR, Gallion HH, Pavlik EJ, DePriest PD. Ovarian Cancer Screening. Cancer. 1995; 76: 2086-2091.
53. DePriest P, Buckley S, Bailey C, et al. Transvaginal sonaography as a screening method for the detection of early ovarian cancer. Gynecologic Oncol. 1995; 56: 129.
54. Pavlik EJ, Nelson K, DePriest PD. quality labeling of gels using transparency mounted photographs and word processing software. BioTechniques. 1996; 21: 1126-1127.
55. De Priest PD, Buckley SL, Bailey CL, et al. Transvaginal Sonography as a Screening Method for the Detection of Early Ovarian Cancer. Gynecol Oncol. 1997; 65: 408-414. doi: http://dx.doi.org/10.1016/S0020-7292(98)90458-1
56. Pavlik EJ, Johnson II TL, De Priest PD, et al. Continuing participation supports ultrasound screening for ovarian cancer. Ultrasound in Obstetrics & Gynecology. 2000; 15: 354-364. doi: 10.1046/j.1469-0705.2000.00069.x
57. Reedy M, Ueland F, Pavlik EJ, De Priest PD, Kryscio RJ, Van Nagell JR. The efficacy of transvaginal sonographic screening in asymptomatic women at risk for ovarian cancer. Gynecologic Oncol. 2000; 77: 350-356. doi: http://dx.doi.org/10.1006/gyno.2000.5816
58. Pavlik EJ, De Priest PD, Gallion HH, et al. Ovarian Volume Related to Age. Gynecologic Oncol. 2000; 77: 410-412. doi: http://dx.doi.org/10.1006/gyno.2000.5783
59. Pavlik EJ, Chengan L, De Priest PD, et al. Relating Ovarian Size to Age, Menopausal Status, and Use of Hormones. Gynecologic Oncol. 2001; 80: 333-334. doi: http://dx.doi.org/10.1006/gyno.2000.6114
60. Wilder JL, Pavlik EJ, Straughn JM, et al. Clinical Implications of a rising serum Ca-125 Within the normal range in patients with epithelial ovarian cancer. Gynecologic Oncology. 2003; 89: 233-235. doi: http://dx.doi.org/10.1016/S0090-8258(03)00051-9
61. Modesitt SC, Pavlik EJ, Ueland FR, De Priest PD, Kryscio RJ, Van Nagell JR, Jr. Risk of malignancy in unilocular ovarian cystic tumors less than 10 cm in diameter. A long-term follow-up study. Obstetrics and Gynecology. 2003; 102: 594-599.
62. Ueland FR, DePriest PD, Pavlik EJ, et al. Preoperative Differentiation of Malignant from Benign Ovarian Tumors: The Efficacy of Morphology Indexing and Doppler Flow Sonography. Gynecologic Oncology. 2003; 91: 46-50. doi: http://dx.doi.org/10.1016/S0090-8258(03)00414-1
63. Pavlik EJ. On those who care for women. Gynecologic Oncology. 2004; 95: 242.
64. Salsman J, Pavlik EJ, Boerner L, Andrykowski M. Clinical, demographic, and psychological characteristics of new, asymptomatic participants in a transvaginal ultrasound screening program for ovarian cancer. Preventive Medicine. 2004; 39: 315-322. doi: 10.1016/j.ypmed.2004.04.023
65. Andrykowski M, Boerner A, Laura M, John M, Pavlik EJ. Psychological Response to Test Results in an Ovarian Cancer Screening Program: A Prospective, Longitudinal Study. Health Psychology. 2004; 23(6): 622-630 doi: http://dx.doi.org/10.1037/0278-622.214.171.1242
66. Ueland FR, DePriest PD, Pavlik EJ, et al. The accuracy of examination under anesthesia and transvaginal sonography in evaluating ovarian size. Gynecologic Oncology. 2005; 99: 400-403. doi: http://dx.doi.org/10.1016/j.ygyno.2005.06.030
67. Dietrich CS III, Modesitt SC, Depriest PD, et al. The efficacy of adjuvant platinum-based chemotherapy in Stage I uterine papillary serous carcinoma(UPSC). Gynecol Oncol. 2005; 99: 557-563. doi: http://dx.doi.org/10.1016/j.ygyno.2005.07.104
68. Gaugler JE, Pavlik EJ, Salsman JM, Andrykowski MA. Psychological and behavioral impact of receipt of a normal ovarian cancer screening test. Preventive Medicine. 2006; 42(6): 463-470 69. DeSimone, CP, Van Ness JS, Cooper, AL, et al. The treatment of lateral T1 and T2 squamous cell carcinomas of the vulva confined to the labium majus or minus. Gynecologic Oncology 2007; 104(2): 390-395. doi: http://dx.doi.org/10.1016/j.ygyno.2006.08.035
70. Dietrich CS III, DeSimone, CP, Modesitt SC, et al. Primary appendiceal cancer: Gynecologic manifestations and treatment options. Gynecologic Oncology. 2007; 104: 602-606. doi: http://dx.doi.org/10.1016/j.ygyno.2006.09.014
71. Michael A. Andrykowski, Mei Zang, Pavlik EJ, Richard Kryscio. Factors Associated with Return for Routine Annual Screening in an Ovarian Cancer Screening Program. Gynecologic Oncology. 2007; 104: 695-701. doi: http://dx.doi.org/10.1016/j.ygyno.2006.10.044
72. Lykins ELB, Pavlik EJ, Andrykowski MA. Validity of self-reports of return for routine repeat screening in an ovarian cancer screening program. Cancer Epidemiol Biomarkers Prev. 2007; 16(3): 490-493. doi: 10.1158/1055-9965.EPI-06-0433
73. John R, Van Nagell JR, DePriest PD, et al. Ovarian cancer screening with annual transvaginal sonography: Findings of 25, 000 women screened. Cancer. 2007; 109(9): 1887-1896. doi: 10.1002/cncr.22594 74. Ryan PY, Graves KD, Pavlik EJ, Andrykowski, MA. Abnormal ovarian cancer screening test result: Womens informational, psychological and practical needs. Journal of Psychosocial Oncology. 2007; 25: 1-18. doi: 10.1300/J077v25n04_01
75. Pavlik EJ, Saunders, Brook A, et al. The Search for Meaning --- Symptoms & TVS Screening for Ovarian Cancer: Predicting Malignancy. Cancer. 2009; 115: 3689-3698. doi: 10.1002/cncr.24407
76. Cooper AL, Nelson DF, Pavlik EJ, et al. Long-Term Survival and Cost of Treatment in Patients With Stage IIIC Epithelial Ovarian Cancer. Current Womens Health Reviews. 2009; 5(1): 44-50. doi: 10.2174/157340409787721294
77. McDonald JM, Doran S, DeSimone CP, et al. Predicting risk of malignancy in adnexal masses. Obstet Gynecol. 2010; 115(4): 687-694. doi: 10.1097/AOG.0b013e3181d44053
78. Saunders BA, Podzielinski I, Pavlik EJ, et al. Risk of Malignancy in Sonographically Confirmed Septated Cystic Ovarian Tumors. Gynecol Oncol. 2010; 118(3): 278-82. doi: 10.1016/j.ygyno.2010.05.013
79. Floyd A, Steffens RF, Pavlik EJ, Andrykowski MA. Receipt of a False Positive Test Result During Routine Screening for Ovarian Cancer: A Teachable Moment? J Clin Psychol Med Settings. 2011; 18: 70–77. doi: 10.1007/s10880-011-9226-7
80. Van Nagell JR, Miller RW, DeSimone CP, et al. Long-Term Survival of Women With Epithelial Ovarian Cancer Detected by Ultrasonographic Screening. Obstetrics & Gynecology 2011; 118: 1212-1221. doi: 10.1097/AOG.0b013e318238d030.
81. Van Nagell JR , Pavlik EJ. Ovarian cancer screening. Clin Obstet Gynecol. 2012; 55(1): 43-51.
82. Pavlik EJ, van Nagell JR. Ovarian Cancer Screening What Women Want. Int J Gynecol Cancer. 2012; 22(Suppl 1): S21-S23. doi: 10.1097/IGC.0b013e318251cbc2.
83. Pavlik EJ, Ueland FR, Miller RW, et al. Frequency and disposition of ovarian abnormalities followed with serial transvaginal ultrasonography. Obstet Gynecol. 2013; 122(2 Pt 1): 210-7. doi: 10.1097/AOG.0b013e318298def5
84. Pavlik EJ, Hoff J, Woolum D, et al. Metrics of the gynecologic oncology literature focused on cited utilization and costs. Gynecologic oncology. 2014; 132(2): 423-427. doi: 10.1016/j.ygyno.2013.12.008
85. Ryan PY, Graves KD, Pavlik EJ, Andrykowski MA. Abnormal ovarian cancer screening test result: womens informational, psychological and practical needs. Journal of psychosocial oncology. 2014; 25(4): 1-18. doi: 10.1300/J077v25n04_01
Wellcome Trust Sparks Research Training Fellow in Maternal & Fetal Medicine
Prenatal Cell and Gene Therapy Group
UCL Institute for Womens Health
86-96 Chenies Mews
WC1E 6HX, London, UK
Panicos is a trainee in Obstetrics and Gynaecology and a PhD Candidate at UCL, in Prenatal Cell and Gene Therapy Group, under the supervision of Dr Anna David and Professor Paolo De Coppi. He graduated from The Royal College of Surgeons in Ireland (RCSI) in 2005. He then moved to Manchester to complete his foundation years. He successfully applied and secured a job in the Obstetrics and Gynaecology training program at the London Deanery in 2007. In 2009 he took a year out of program, to undertake a masters degree at UCL, in Prenatal Genetics and Fetal Medicine. His research project was on “Cell proliferation in the uterine arteries of pregnant sheep, transduced with adenovirus VEGF-D”, under the supervision of Dr Anna David. He was awarded, January 2011 with a CDRC/UCLH Charities Entry Level Fellowship and in June 2012, with a joint Wellcome Trust Sparks RTF to start a PhD on the project “Can we treat congenital blood disorders by transplantation of stem cells to the fetus?”.
His research interests include: Stem cell research, Fetal medicine in utero stem cell transplantation in utero gene therapy, Prenatal therapy and Fetal intervention.
• University College London, MSc in Prenatal Genetics and Fetal Medicine (Distinction with 90% in the research project) London, November (2010)
• Society of Gynaecologic Investigation (SGI) Award for Best Investigator Poster Presentation Orlando, Florida, March (2013)
• Society of Gynaecologic Investigation (SGI) SGI Presidents Presenter Awards. This award conveys a $1,000.00 research grant. The award was made possible by a grant from Pfizer, Florence, Italy March (2014)
• UCLs institute for Womens Health Best PhD/MD Poster Presentation, May (2014 International Fetal Medicine and Surgery Society (IFMSS): $1000 Travel Award & $1500 Vandenberghe-Storz Award for the best oral presentation by a trainee, Chatham, MA, USA, September (2014)
• June (2009) The A.G. Leventis Foundation Scholarship, £5,000 to cover the fees for the UCL Institute for Womens Health MSc Prenatal Genetics and Fetal Medicine, during the academic year (2009-2010)
• February (2011) UCLH Charities Clinical Research and Development Committee Entry-Level Fellowship: fund a PhD An in utero stem cell transplantation gene therapy approach for prenatal therapy of thalasseamia, £89417
• December (2011) Bogue Travel Fellowship, £1548, to visit Professor Ryans laboratory at UAB to study a humanized mouse model of thalassemia
• July (2012) Wellcome Trust, SPARKS Research Training Fellowship, March (2013-2015) to complete the project: Can we treat genetic blood disorders by transplantation of stem cells to the fetus?. £181,169
1. Pipino C, Panicos S, Elisa R, et al. Placenta as a Reservoir of Stem Cells: An Underutilized Resource? British Medical Bulletin. 2012; 105: 1-25. doi: 10.1093/bmb/lds033
2. Shaw SW, Blundell MP, Pipino C, et al. Sheep CD34+ Amniotic Fluid Cells Have Haematopoietic Potential and Engraft after Autologous in Utero Transplantation.Stem Cells (Dayton, Ohio). 2014. doi: 10.1002/stem.1839
3. Maghsoudlou P, Georgiades F, Tyraskis A, et al. Preservation of Micro-Architecture and Angiogenic Potential in a Pulmonary Acellular Matrix Obtained Using Intermittent Intra-Tracheal Flow of Detergent Enzymatic Treatment. Biomaterials. 2013; 34(28): 6638-6648. doi: 10.1016/j.biomaterials.2013.05.015
4. Mehta V, Abi-Nader KN, Shangaris P, et al. Local Over-Expression of VEGF-DΔNΔC in the Uterine Arteries of Pregnant Sheep Results in Long-Term Changes in Uterine Artery Contractility and Angiogenesis. PLOS One. 2014; 9(6): e100021. doi: 10.1371/journal.pone.0100021.
5. Pipino C, Mukherjee S, David AL, et al. Trisomy 21 Mid-Trimester Amniotic Fluid Induced Pluripotent Stem Cells Maintain Genetic Signatures During Reprogramming: Implications for Disease Modeling and Cryobanking. Cellular Reprogramming. 2014; 16(5): 1-14. doi: 10.1089/cell.2013.0091
6. Selo-Ojeme D, Rogers C, Mohanty A, et al. Is Induced Labour in the Nullipara Associated with More Maternal and Perinatal Morbidity? Archives of Gynecology and Obstetrics. 2011; 284(2): 337-341. doi: 10.1007/s00404-010-1671-2
Research Assistant Professor
Department of Obstetrics & Gynecology
Carve college of Medicine
The University of Iowa
MERF 3234, 375 Newton Road
Iowa City, IA, 52242, USA
• 1985-1990 B.A. Biochemistry , Beijing Normal University, Beijing, China
• 1995-1998 Ph.D. Molecular Biology & Biochemistry, Beijing Institution of Radiation Medicine, Beijing, China
• 1993-1995 Research Associate, Dept. of Radiotoxicology and Radiation Protection, Institute of Radiation, Medicine, Beijing, China
• 1995- 2000 Research Associate, Dept. of Biochemistry, Beijing Institute of Radiation
• 2000- 2003 Postdoctoral fellow, Dept. of Molecular Genetics & Microbiology, University of New Mexico, School of Medicine
• 2002 Young investigator travel award, in 49th Annual Meeting of the Radiation Research Society, Reno, Nevada.
• 2003 Travel Award, Graduate/Postdoctoral Travel Fellowships, ASBMB (American Society for Biochemistry and Molecular Biology), San Diego, CA.
• 2003- 2005 Scientist, Dept. of Molecular Genetics & Microbiology, University of New Mexico School of Medicine
• 2006-2009 Scientist, Dept. of Pathology, University of New Mexico School of Medicine
• 2009-Present Research Assistant Professor, Dept. of OB & GYN, University of Iowa Carver College of Medicine
His research interests include: Mechanistic studies of drug resistance in cancers partnered with translational studies to identify targeted therapies to overcome drug resistance.His study recently made the novel discovery that MTDH acts as an RNA binding protein to alter translation of many genes involved in DNA damage repair. These observations indicate MTDH function as the potential target to overcome drug resistance.
New prognosis biomarkers and potential therapeutic targets in gynecology; Synthetic lethal studies in gynecology; Mitotic Catastrophe induction in ovarian and endometrial cancer
1. Meng X, Yuan Y, Maestas A, ShenZ. Recovery from DNA damage-induced G2-arrest requires the actin binding protein filamin-A/ABP-280. J Biol Chem. 2004; 279(7): 6098-6105. doi: 10.1074/jbc.M306794200
2. Meng X, Brachova P, Yang S, et al. Knockdown MTDH Sensitizes Endometrial Cancer Cells to Cell Death Induction by Death Receptor Ligand TRAIL and HDAC inhibitor LBH589 Co-Treatment. PLoS ONE. 2011; 6(6):e20920. doi: 10.1371/journal.pone.0020920
3. Meng X, Zhu D, Yang S, et al. Cytoplasmic MTDH provides a survival advantage under conditions of stress by acting as an RNA binding protein. J Biol Chem. 2012; 287(7): 4485-91. doi: 10.1074/jbc.C111.291518.
4. Meng, X, Yue, J, Liu, Z and Shen Z. Abrogation of the transactivation activity of p53 by BCCIP down-regulation. J BiolChem. 2007; 282(3): 1570-6. doi: 10.1074/jbc.M607520200
5. Meng X, Fan J and Shen Z. Roles of BCCIP in chromosome stability and cytokinesis. Oncogene. 2007; 26(43): 6253-60. doi: 10.1038/sj.onc.1210460
6. Meng X, Liu J, Shen Z. Inhibition of G1 to S cell cycle progression by BCCIPβ. Cell Cycle. 2004; 3(3): 343-348. doi: 10.4161/cc.3.3.672
7. Meng X, Lu H, ShenZ. BCCIP functions through p53 to regulate the expression of p21Waf1/Cip1. Cell Cycle. 2004; 3(11): 1457-1462. doi: 10.4161/cc.3.11.1213
8. Lu H, Guo X, Meng X, et al. The BRCA2-interacting protein BCCIP functions in RAD51 and BRCA2 focus formation and homologous recombinational repair. Mol Cell Biol. 2005; 25(5): 1949-57. doi: 10.1128/MCB.25.5.1949-1957.2005
9. Russell T, Oliver JM, Wilson BS, Winter SS, Meng X. Ikaros splice variants in monozygotic twins with MLL-rearranged precursor-B acute lymphoblastic leukemia. J. Pediatric Hematology Oncology. 2008; 30(12): 941-4. doi: 10.1097/MPH.0b013e318180bbf5
10. Meng X, Martinez MA, Raymond-Stintz MA, Winter SS, Wilson BS. IKK Inhibitor Bay 11-7082 Induces Necroptotic Cell Death In Precursor-B Acute Lymphoblastic Leukaemic Blasts. Br J Haematol. 2009; 148(3): 487-90. doi: 10.1111/j.1365-2141.2009.07988.x
11. Luo W, Wu F, Beck BB, et al. Amifostine enhancement of the anti-cancer effects of paclitaxel in endometrial cancer is TP53-dependent. Int J Oncol. 2010; 37(5): 1187-94. doi: 10.3892/ijo_00000770
12. Meng X, Matlawska-Wasowska KM, Girodon F, et al. GSI-I (Z-LLNle-CHO) inhibits gamma-secretase and the proteosome to trigger cell death in precursor-B acute lymphoblastic leukemia. Leukemia. 2011; 25(7): 1135-46. doi: 10.1038/leu.2011.50
13. Yang S, Xiao X, Meng X, Leslie KK. A mechanism for synergy with combined mTOR and PI3 kinase inhibitors. PLoS One. 2011; 6(10): e26343. doi: 10.1371/journal.pone.0026343.
14. Milhem MM, Knutson T, Yang S, et al. Correlation of MTDH/AEG-1 and HOTAIR expression with metastasis and response to treatment in sarcoma patients. J Cancer SciTher. 2011; S5: 004. doi: 10.4172/1948-5956.S5-004
15. Meng X, Laidler LL, Kosmacek EA, et al. Induction of mitotic cell death by overriding G2/M checkpoint in endometrial cancer cells with non-functional p53. GynecolOncol. 2013; 128(3): 461-9. doi: 10.1016/j.ygyno.2012.11.004
CRI Developmental Vascular Biology Program
Translational Biomedical Research Center
Medical College of Wisconsin
Department of Pediatrics
8701 Watertown Plank Road
P.O. Box 26509, Milwaukee, WI 53226, USA
Dr. Ramchandran received his PhD from the Georgia Regents University, Augusta, Georgia, USA in 1997. Currently, he is a tenured Professor at the Medical College of Wisconsin, Milwaukee, WI. He is the Patrick J. and Margaret G. McMahon Professor in Obstetrics and Gynecology, and Vice Chair for Research in the Department of Obstetrics and Gynecology, in addition to his responsibilities as the Director of the Developmental Vascular Biology Program, and Director of the Zebrafish Drug Screening Core. His research has included investigation of the basic mechanisms of blood vessel formation in vertebrates, and how those vessels contribute to diseases. His lab studies developing zebrafish and mouse embryos to gain insights into vascular conditions associated with children, such as hemangiomas and solid tumors. In addition to studying blood vessel formation, his lab is also developing tools for performing drug screens using zebrafish embryos, which will identify targets and potential drug leads for treating pediatric vascular conditions.
Based on this research and fellowship training he/she has received several awards and honors. Some of them include the 2002 NCI Scholar Award, and the 2013 Distinguished Alumnus Award at Georgia Regents University. He serves on the editorial board of Vascular Cell, Indian Journal of Clinical Medicine and PLoS ONE journals, and is an expert reviewer for several leading journals including Cancer Research, FASEB, Journal of Biological Chemistry, Nature, Blood, PNAS, Circulation Research, and Nature Communications. He has authored 49 research articles/books, and is a member of the American Association of Cancer Research, American Association of Anatomists, American Heart Association, the North American Vascular Biology Association and the Society for Developmental Biology.
His research interests include: Developmental Vascular Biology: Vasculogenesis and Angiogenesis Mechanisms in Zebrafish and Mice, Vessel and Axon Guidance, Zebrafish Chemical Biology, Translational Models of Disease, Tumor Metastasis.
AWARDS AND HONORS:
• 1990- Batliboi Scholarship Award (Bachelors)
• 1991- Batliboi Scholarship Award (Masters)
• 1992- Tata Memorial Scholarship Award (Higher studies in U.S.), Graduate Research Assistantship Award (PhD)
• 1997 Third place, Sigma XI, Named in Whos Who Among Students in American Universities and Colleges, Special Recognition Award from Student Government Association, MCG
• 2001- Ruth L. Kirchstein NRSA Award
• 2002- NCI Scholar Award
• 2004- Nominated for Outstanding Mentor Award, NCI, NIH
• 2006- Named in Madison Whos Who of business leaders and professionals,Cash Performance Award, NIH
• 2007- Two Year Complimentary Membership to American Association of Anatomist (successful nomination of a Bensley Award Recipient)
• 2010- Donald and Judith Alstadt Research Foundation Award
• 2012- Clinical & Translational Science Institute – In Recognition of Outstanding Contributions to the Master of Science Program in Clinical & Translational Science
• 2013- Distinguished Alumnus Award, Georgia Regents University, Nominated for Diversity Award, Medical College of Wisconsin
• 2014- Community of Innovators Awards – Research, Medical College of Wisconsin
MEMBERSHIPS AND PROFESSIONAL SCIENTIFIC SOCIETIES:
• Past- American Association for the Advancement of Science, American Association for Cancer Research, American Society of Gene Therapy
• Current- American Association of Anatomists, Association for Laboratory Automation, North American Vascular Biology Association, Society for Developmental Biology
1. Dhanabal M, Ramchandran R, Volk R, et alEndostatin: yeast production, mutants, and antitumor effect in renal cell carcinoma. Cancer Res. 1999; 59: 189-197.
2. Ramchandran R, Dhanabal M, Volk R, et al. Anti-angiogenic activity of Restin, NC10 domain of human Collagen XV: Comparison to Endostatin. Biochem. and Biophys. Res Comm. 1999; 255: 735-739. doi: 10.1006/bbrc.1999.0248
3. Dhanabal M, Volk R, Ramchandran R, Simons M, Sukhatme VP. Cloning, expression, and in vitro activity of human Endostatin. Biochem and Biophys Res Comm. 1999; 258: 345-352. doi: 10.1006/bbrc.1999.0595
4. Lu H, Dhanabal M, Volk R, et al. Kringle 5 causes cell cycle arrest and apoptosis of endothelial cells. Biochem and Biophys Res Comm. 1999; 258: 668-673. doi: 10.1006/bbrc.1999.0612
5. Dhanabal M, Ramchandran R, Waterman MJF, et al. Endostatin induces endothelial cell apoptosis. J Biol Chemistry. 1999; 274: 11721-11726. doi: 10.1074/jbc.274.17.11721
6. Kamphaus GD, Colorado PC, Panka DJ, et al. Canstatin: A novel matrix-derived inhibitor of angiogenesis and tumor growth. J Biol Chemistry. 2000; 275: 1209-1215. doi: 10.1074/jbc.275.2.1209
7. Ramchandran R, Bengra C, Whitney B, Lanclos K, Tuan D. A (GATA)7 motif located in the 5 boundary area of the human b-globin locus control region exhibits conditional silencer activity. Am J of Hematology 2000; 65: 14-24. doi: 10.1002/1096-8652(200009)65:1<14::AID-AJH3>3.0.CO;2-F
8. Hanna NN, Seetharam S, Mauceri HJ, et al. Antitumor interaction of short-course endostatin and ionizing radiation. Cancer J. 2000; 6: 287-293.
9. Karumanchi SA, Jha V, Ramchandran R, et al. Cell surface glypicans are low-affinity endostatin receptors. Molecular Cell. 2001; 7: 811-822. doi: http://dx.doi.org/10.1016/S1097-2765(01)00225-8
10. Hanai JJ, Gloy J, Karumanchi SA, et al. Endostatin is a potential inhibitor of Wnt signaling. J Cell Biology. 2002; 158: 529-539. doi: 10.1083/jcb.200203064
11. Hanai JJ, Dhanabal M, Karumanchi SA, et al. Endostatin causes G1 arrest of endothelial cells through inhibition of cyclin D1. J Biol Chemistry. 2002; 277: 16464-16469. doi: 10.1074/jbc.M112274200
12. Chan B, Sinha S, Cho D, Ramchandran R, Sukhatme VP. Critical roles of CD146 in zebrafish vascular development. Dev Dynamics. 2005; 232: 232-244. doi: 10.1002/dvdy.20220
13. Bedell V, Yeo SY, Park KW, et al. Roundabout4 is essential for angiogenesis in vivo. PNAS. 2005; 102: 6373-78. doi: 10.1073/pnas.0408318102
14. Kaur S, Castellone, MD, Bedell VM, Konar M, Gutkind JS, Ramchandran R. Robo4 signaling in endothelial cells imply attraction guidance mechanisms. J Biol Chemistry. 2006; 281 (16): 11347-11356. doi: 10.1074/jbc.M508853200
15. Hu G, Tang J, Zhang B, et al. HSPA12B is essential in zebrafish vascular development. J Cell Science. 2006; 119, 4117-4126.
16. Arbiser JL, Kau T, Konar M, et al. Solenopsin, the alkaloidal component of the fire ant (Solenopsis invicta), is a naturally occurring inhibitor of phosphatidylinositol-3-kinase signaling and angiogenesis. Blood. 2007. 109(2): 560-565. doi: http://dx.doi.org/10.1182/blood-2006-06-029934
17. Kanungo J, Li BS, Goswami M, Zheng YL, Ramchandran R, Pant HC. Cloning and characterization of zebrafish (Danio rerio) Cyclin dependent kinase 5. Neurosci Lett. 2007; 412 (3): 233-238. doi: 10.1016/j.neulet.2006.11.016
18. Isenberg JS, Jia Y, Field L, et al. Modulation of Angiogenesis by Dithiolethione-modified NSAIDs and Valproic Acid. Br J Pharmacol. 2007; 151(1): 63-72. doi: 10.1038/sj.bjp.0707198
19. Kaur S, Abu-Abab MS, Singla S, Yeo SY, Ramchandran R. Expression pattern for unc5b, an axon guidance gene in embryonic zebrafish development. Gene Expression. 2007; 13(6): 321-327. doi: http://dx.doi.org/10.3727/000000006781510714
20. Garnaas MK, Liu M, Marx R, et al. Syx, a novel Rho A guanine exchange factor, is essential for angiogenesis in vivo. Circulation Research. 2008; 103(7):710-716. doi: 10.1161/CIRCRESAHA.108.181388
21. Kaur S, Samant GV, Pramanik K, et al. Silencing of directional migration in robo4 knockdown endothelial cells. BMC Cell Biology. 2008; 39: 61. doi: 10.1186/1471-2121-9-61
22. Makky K, Duvnjak P, Pramanik K, Ramchandran R, Mayer AN. A whole-animal microplate assay for metabolic rate using zebrafish. Journal of Bio Molecular Screening. 2008; 13(10): 960-967. doi: 10.1177/1087057108326080
23. Pramanik K, Chun CZ, Garnaas MK, et al. Dusp-5 and Snrk-1 coordinately function during vascular development and disease. Blood. 2009; 113 (5): 1184-1191. doi: 10.1182/blood-2008-06-162180
24. Kanungo J, Zhen, Y, Amin N, Kaur S, Ramchandran R, Pant H. Specific inhibition of cyclin-dependent kinase 5 activity induces motor neuron development in vivo. Biochem and Biophys. Res. Comm. 2009; 386: 263-267. doi: 10.1016/j.bbrc.2009.06.038
25. Chun CZ, Kaur S, Samant GV, et al. Snrk-1 is involved in multiple steps of angioblast development and acts via notch signaling pathway in artery-vein specification in vertebrates. Blood. 2009; 113(5): 1192-1199. doi: 10.1182/blood-2008-06-162156
26. Jia Y, Wu S-L, Isenberg JS, et al. Thiolutin inhibits endothelial cell adhesion by perturbing Hsp27 interactions with the actin cytoskeleton. Cell Stress Chaperones. 2010; 15(2): 165-181. doi: 10.1007/s12192-009-0130-0.
27. Li K, Blum Y, Verma A, et al. A noncoding antisense RNA at the tie-1 locus regulates tie-1 transcript levels function in vivo. Blood. 2010; 115(1): 133-139. doi: 10.1182/blood-2009-09-242180
28. Verma A, Bhattacharya R, Remadevi I, et al. Ecscr promotes angioblast migration during vasculogenesis and enhances kdr sensitivity. Blood. 2010; 115(22): 4614-4622. doi: 10.1182/blood-2009-10-248856
29. Zhao B, Chun C, Liu Z, et al. Nogo-B receptor is essential for angiogenesis in vivo via Akt pathway. Blood. 2010; 116(24):5423-5433. doi: 10.1182/blood-2010-02-271577
30. Chun CZ, Remadevi I, Schupp M, et al. Fli+ etsrp+ hemato-vascular progenitor cells proliferate at the lateral plate mesoderm during vasculogenesis in zebrafish. PLoS One. 2011; 6(2): e14732. doi: 10.1371/journal.pone.0014732.
31. Lakshmikanthan S, Sobczak M, Chun CZ, et al. Rap1b regulates angiogenesis by an endothelial cell-autonomous mechanism involving integrin αvβ3-dependent VEGFR2 activation. Blood. 2011; 118(7): 2015-2026.
32. SamantGV, SchuppMO, François M, et al. Sox factors transcriptionally regulate robo4 expression in the developing vasculature in zebrafish. J Biol Chem. 2011; 286(35): 30740-30747. doi: 10.1074/jbc.M111.220665
33. Patra C, Kim J, Pramanik K, et al. Reactive oxygen species driven angiogenesis by inorganic nanorods. Nano Lett. 2011; 11(11): 4932-14938. doi: 10.1021/nl2028766
34. Wickramasekera N, Gebremedhin D, Carver K, et al. Role of dual-specificity protein phosphatase-5 (DUSP-5) in modulating myogenic response in rat cerebral arteries. Paper : JAPPL-01026-2011R3. J Appl Physiol. 2013; 114(2): 252-261. doi: 10.1152/japplphysiol.01026.2011
35. Kilari S, Remadevi I, Zhao B, et al. Endothelial cell-specific chemotaxis receptor (ECSCR) enhances vascular endothelial growth factor (VEGF) receptor-2/kinase insert domain receptor (KDR) activation and promotes proteolysis of internalized KDR. J Biol Chem. 2013; 288(15): 10265-10274. doi: 10.1074/jbc.M112.413542
36. Span EA, Goodsell DS, Ramchandran R, Franzen M, Hemran T, Sem DS. Protein structure in context: The molecular landscape of angiogenesis. Biochem Mol Biol Educ. 2013; 41(4): 213-23. doi: 10.1002/bmb.20706.
37. Leigh NR, Schupp MO, Li K, et al. Mmp17b and its putative substrate Reck are essential for neural crest migration in vivo. PLoS ONE. 2013; 8(10): e76484. doi: 10.1371/journal.pone.0076484
38. Wang L, Cossette SM, Rarick KR, et al. Astrocytes directly influence tumor cell invasion and metastasis in vivo. PLoS ONE. 2013; 8(12): e80933. doi: 10.1371/journal.pone.0080933.
39. Zhou X, Fan LX, Li K, Ramchandran R, Calvet JP, Li X. SIRT2 regulates ciliogenesis and contributes to abnormal centrosome amplification caused by loss of polycystin-1. Hum Mol Genet. 2014; 23(60): 1644-1655. doi: 10.1093/hmg/ddt556
40. Schupp MO, Waas M, Chun CZ, Ramchandran R. Transcriptional inhibition of etv2 expression is essential for embryonic cardiac development. Dev Biol. 2014; Pii: S0012-1606(14)00315-7. doi: 10.1016/j.ydbio.2014.06.019
Professor, Psychiatry and Ob/Gyn
Director, Behavioral Medicine
Wayne State University SOM
CS Mott Center, 275 E. Hancock
Detroit, MI 48201, USA
• (1969-1975)- University of Michigan, Department of Psychology, M.A. in Clinical Psychology, 1973 and Ph.D. in Clinical Psychology, 1975
• (1965-1969)- University of Chicago, B.A. in Psychology, 1969
• (2000-present )- Associate, Department of Internal Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, Wayne State, University School of Medicine.
• (1993-present)- Professor, Department of Obstetrics and Gynecology, Wayne State University School of Medicine.
• (1989-present)- Professor, Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine.
• (1989-present)- Adjunct Professor, Department of Psychology, Wayne State University
• (1987-present)- Faculty, Program in Cellular and Clinical Neurobiology, Wayne State University School of Medicine (Founding Member)
• (1984-present)- Faculty, Neuroscience Program, Wayne State University School of Medicine
• (1983-1989)- Associate Professor, Departments of Psychology (Adjunct) and Psychiatry, Wayne State University
• (1976-1983)- Adjunct Assistant Professor, Department of Psychology, Wayne State University
His research interests include: Menopause, hot flashes, thermoregulation and sleep.
HONORS AND AWARDS:
• Student Paper Award, International Congress of Sleep Research, Edinburgh, 1975
• Academy of Behavioral Medicine Research, elected 1981
• Presidential Citation Award, Society of Behavioral Medicine, 1983
• Who’s Who in Science and Technology, 1983
• Who’s Who in the Midwest, 1983
• Claude Bernard Club, elected 1984
• Outstanding Paper Award, Biofeedback Society of America, 1985
• Citation Paper Award, Biofeedback Society of America, 1987
• Men of Achievement, 1987
• Who’s Who in the Biobehavioral Sciences, 1987
• American Men and Women of Science, 1988
• Research Recognition Award, Biofeedback Society of America, 1988
• Citation Paper Award, Biofeedback Society of America, 1988
• Certificate of Appreciation, United Scleroderma Foundation, 1988
• Citation Paper Award, Association for Applied Psychophysiology and Biofeedback, 1989
• Certificate of Commendation, National Institute of Mental Health, 1991
• Elected Fellow, Society of Behavioral Medicine, 1991
• Citation Paper Award, Association for Applied Psychophysiology, 1992
• Outstanding Paper Award, Association for Applied Psychophysiology, 1993
• Citation Poster Award, Society of Behavioral Medicine, 1993
• Citation Paper Award, Society of Behavioral Medicine, 1993
• Invited Citation Lecture, Association for Applied Psychophysiology, 1994
• Best Free Communication Award, North American Menopause Society, 1994
• Who’s Who in the World, 1995
• Citation Paper Award, Society of Behavioral Medicine, 1995, 1996
• Best Free Communication Award, North American Menopause Society, 1995
• Outstanding Paper Award, Association for Applied Psychophysiology, 1996
• NIH Merit Award, National Institute on Aging, 1996
• Who’s Who in Medicine and Health Care, 1996
• Citation Paper Award, Association for Applied Psychophysiology, 1999
• Citation Poster Award, Society of Behavioral Medicine, 1999
• Outstanding Basic Scientist Award, Wayne State University School of Medicine, 2000
• Vasomotor Symptoms Research Award, North American Menopause Society, 2002
• Best Poster Award, Michigan Society for Neuroscience, 2006
• Who’s Who in America, 2006
• International Journal of Women’s Health, Honorary, 2008, 2009
• Open Access Journal of Contraception, Honorary, 2009
• Mentor, North American Menopause Society, 2009, 2010, 2011
• Academic Keys Who’s Who in Medicine Higher Education, 2011
MAJOR PROFESSIONAL SOCIETIES:
• American Association for the Advancement of Science
• American Heart Association Council on Basic Cardiovascular Sciences
• American Physiological Society
• American Psychological Association
• American Psychosomatic Society
• Association for the Psychophysiological Study of Sleep
• Biofeedback Society of America
• North American Menopause Society (Founding Member)
• Society of Behavioral Medicine
• Society for Psychophysiological Research
1. Freedman RR. Menopausal hot flashes: Mechanisms, endocrinology, treatment. The Journal of Steroid Biochemistry and Molecular Biology. 2013. doi: 10.1016/j.jsbmb.2013.08.010.
2. Diwadkar V, Murphy ER, Freedman RR. Temporal sequencing of brain activations during naturally occurring thermoregulatory events. Cerebral Cortex. 2013. doi: 10.1093/cercor/bht155.
3. Archer DF, Studee DW, Baber R, et al. Menopausal hot flushes and night sweats: Where are we now? Climacteric. 2011; 14(5): 515-528. doi: 10.3109/13697137.2011.608596.
4. Freedman RR, Kruger ML, Tancer ME. Escitalopram treatment of menopausal hot flashes. Menopause. 2011; 18(8): 893-896. doi: 10.1097/gme.0b013e31820ccae9.
5. Freedman RR, Kruger ML, Wasson SL. Heart rate variability in menopausal hot flashes during sleep. Menopause. 2011; 18(8): 897-900. doi: 10.1097/gme.0b013e31820ac941.
6. Freedman RR. Objective or subjective measurement of hot flushes in clinical trials: Quo vadis. Maturitas. 2010; 67(2): 99-100. doi: 10.1016/j.maturitas.2010.06.011
7. Freedman RR. Treatment of menopausal hot flashes with 5-hydroxytryptophan. Maturitas. 2010; 65(4): 383-385. doi: 10.1016/j.maturitas.2009.11.025.
8. Freedman RR. Patient satisfaction with miniature, ambulatory, postmenopausal hot flash recorder. The Open Medical Devices Journal.2009; 1: 1-2.
9. Utian WH, Archer DF, Bachmann GA, et al. North American Menopause Society. Estrogen and progestogen use in postmenopausal women: July 2008 position statement of The North American Menopause Society. Menopause. 2008; 15(4 Pt 1): 584-602. doi: 10.1097/gme.0b013e31817b076a.
10. Freedman RR. Biochemical mechanisms of menopausal hot flushes. British Journal of Sexual Medicine. 2007; 30(1): 8-10.
11. Freedman RR. How much of a difference does it take to make a difference? Fertility and Sterility. 2007; 87(6): 1497-1498. doi: http://dx.doi.org/10.1016/j.fertnstert.2007.01.138
12. Freedman RR, Roehrs TA. Sleep disturbance in menopause. Menopause. 2007; 14(5): 826-829. doi:
13. Freedman RR, Wasson S. Miniature, hygrometric hot flash recorder. Fertility and Sterility. 2007; 88(2): 494-496. doi: http://dx.doi.org/10.1016/j.fertnstert.2006.11.184
14. Freedman RR, Roehrs TA. Effects of REM sleep and ambient temperature on hot flash-induced sleep disturbance. Menopause. 2006; 13(4): 576-583. doi: 10.1097/01.gme.0000227398.53192.bc
15. Freedman RR, Benton MD, Genik RJ, Graydon FX. Cortical activation during menopausal hot flashes. Fertility and Sterility. 2006; 85(3): 674-678. doi: http://dx.doi.org/10.1016/j.fertnstert.2005.08.026
16. Freedman RR, Johanson C.-E, Tancer ME. Thermoregulatory effects of 3,4-methylene-dioxymethamphetamine (MDMA) in humans. Psychopharmacology. 2005; 183(2): 248-256.
17. Furspan PB, Chatterjee S, Mayes M, Freedman RR. Cooling-induced contraction and protein tyrosine kinase activity of isolated arterioles in secondary Raynauds phenomenon. Rheumatology. 2005; 44(4): 488-494. doi:10.1093/rheumatology/keh517
18. Freedman RR, Subramanian M. Effects of symptomatic status and the menstrual cycle on hot flash-related thermoregulatory parameters. Menopause. 2005; 12(2): 156-159.
19. Furspan PB, Chatterjee, S, Freedman RR. Increased tyrosine phosphorylation mediates the cooling- induced contraction and increased vascular reactivity of Raynauds disease. Arthritis and Rheumatism. 2004; 50(5): 1578-1585. doi: 10.1002/art.20214
20. Freedman RR, Roehrs, T.A. Lack of sleep disturbance from menopausal hot flashes. Fertility and Sterility. 2004; 82(1): 138-144. doi: http://dx.doi.org/10.1016/j.fertnstert.2003.12.029
21. Carpenter, J.S, Gilchrist, J.M, Chen, K, Gautam, S, Freedman RR. Hot flashes, core body temperature and metabolic parameters in breast cancer survivors. Menopause. 2004; 11(4): 375-381.
22. Freedman RR. Core body temperature variation in symptomatic and asymptomatic postmenopausal women. Menopause. 2002; 9(6): 399-401.
23. Leidy Sievert L, Freedman RR, Garcia JZ, et al. Measurement of hot flashes by sternal skin conductance and subjective hot flash report in Puebla, Mexico. Menopause. 2002; 9(5): 367-376.
24. Freedman RR, Blacker CM. Estrogen raises the sweating threshold in postmenopausal women with hot flashes. Fertility and Sterility. 2002; 77(3): 487-490. doi: http://dx.doi.org/10.1016/S0015-0282(01)03009-6
25. Middaugh, SJ, Haythornthwaite JA, Thompson B, et al. The Raynauds treatment study: Biofeedback protocols and acquisition of temperature biofeedback skills. Applied Psychophysiology and Biofeedback. 2001; 26(4): 251-278.
26. Furspan PB, Mayes MD, Freedman RR. Effect of temperature and modulators of protein tyrosine kinase activity on the reactivity of isolated venules in secondary Raynauds phenomenon. Journal of Rheumatology. 2001; 28(10): 2263-2268.
27. Carpenter J, Gautam S, Freedman RR, Andrykowski M. Circadian rhythm of objectively recorded hot flashes in postmenopausal breast cancer survivor. Menopause. 2001; 8(3): 181-188.
28. Freedman RR, Girgis R, Mayes MD. Abnormal responses to endothelial agonists in Raynauds phenomenon and scleroderma. Journal of Rheumatology. 2001; 28(1): 119-121.
29. Freedman RR. Physiology of hot flashes. American Journal of Human Biology. 2001; 13(4): 453-464.
30. Freedman RR, Dinsay R. Clonidine raises the sweating threshold in symptomatic but not asymptomatic postmenopausal women. Fertility and Sterility. 2000; 74(1): 20-23. doi: http://dx.doi.org/10.1016/S0015-0282(00)00563-X
31. Freedman RR, Girgis R. Effects of menstrual cycle and race on peripheral vascular alpha-adrenergic responsiveness. Hypertension. 2000; 35(3): 795-799. doi: 10.1161/01.HYP.35.3.795
32. RTS Study Group. Comparison of sustained-release nifedipine and temperature biofeedback for primary Raynauds phenomenon: Results from a randomized clinical trial with one-year follow-up. Archives of Internal Medicine. 2000; 160: 1101-1108. doi: 10.1001/archinte.160.8.1101.
33. Freedman RR, Girgis R, Mayes M. Endothelial and adrenergic dysfunction in Raynauds phenomenon and scleroderma. Journal of Rheumatology. 1999; 26(11): 2386-2388.
34. Freedman RR, Girgis R, Mayes M. Acute effect of nitric oxide on Raynauds phenomenon in scleroderma. Lancet. 1999; 354(9180): 739. doi:10.1016/S0140-6736(99)03557-6
35. Jennings JR, Canner J, Thompson B, et al. A thermal vascular test for distinguishing between patients with Raynauds phenomenon and healthy controls. Health Psychology. 1999; 18(4): 421-426. doi: http://dx.doi.org/10.1037/0278-6126.96.36.1991
36. Carpenter JS, Andrykowksi MA, Freedman RR, Munn R. Feasibility and psychometrics of an ambulatory hot flash monitoring device. Menopause. 1999; 6(3): 209-215.
37. Freedman RR, Krell W. Reduced thermoregulatory null zone in postmenopausal women with hot flashes. American Journal of Obstetrics and Gynecology. 1999; 181(1): 66-70.
38. Thompson B, Geller NL, Hunsberger S, et al. Behavioral and pharmacologic interventions: the Raynauds Treatment Study. Controlled Clinical Trials. 1999; 20(1): 52-63. doi: 10.1016/S0197-2456(98)00046-4
39. Freedman RR. Biochemical, metabolic, and vascular factors in menopausal hot flashes. Fertility and Sterility. 1998; 70(2): 332-337.
40. Furspan P, Freedman RR. Effects of protein tyrosine kinase activity on gender-related differences in vascular reactivity at reduced temperature. Journal of Cardiovascular Pharmacology. 1998; 32(5): 728-735.
41. Song J, Ram JL, Furspan PB, Freedman RR. Differences in α2 -adrenoceptormodulation of calcium channels in vascular smooth muscle cells of male and female rats. Pflugers Archives-European Journal of Physiology. 1996; 433(1-2): 212-214.
42. Freedman RR, Mayes M. Familial aggregation of primary Raynauds disease. Arthritis and Rheumatism. 1996; 39(7): 1189-1191.
43. Freedman RR, Woodward S. Core body temperature during menopausal hot flashes. Fertility and Sterility. 1996; 65(6): 1141-1149.
44. Freedman RR, Woodward S, Brown B, Javaid J, Panday G. Biochemical and thermoregulatory effects of behavioral treatment for menopausal hot flashes. Menopause. 1996; 2(4): 211-218.
45. Freedman RR, Woodward S. Altered shivering threshold in postmenopausal women with hot flashes. Menopause. 1995; 2(3): 163-168.
46. Freedman RR, Baer RP, Mayes M. Blockade of vasospastic attacks by α2-adrenergic, but not α1-adrenergic antagonists in idiopathic Raynauds disease. Circulation. 1995; 92(6): 1448-1451.
47. Freeman K, Farrow S, Schmaier A, Freedman RR, Schork T, Lockette W. Genetic polymorphism of the alpha 2-adrenergic receptor is associated with increased platelet aggregation, baroreceptor sensitivity, and salt excretion in normotensive humans. American Journal of Hypertension. 1995; 8(9): 863-869. doi: 10.1016/0895-7061(95)00155-I
48. Freedman RR, Norton D, Woodward S. Core body temperature and circadian rhythm of hot flushes in menopausal women. Journal of Clinical Endocrinology and Metabolism. 1995; 80(8): 2354-2358. doi:http://dx.doi.org/10.1210/jcem.80.8.7629229
49. Woodward S, Greville H, Freedman RR. Ventilatory response during menopausal hot flashes. Menopause. 1995; 2(2): 81-88. doi:
50. Freedman RR, Moten M. Gender differences in modulation of peripheral vascular adrenoceptors. Annals of Behavioral Medicine. 1995; 17(1): 15-18. doi: 10.1007/BF02888802.
51. Freedman RR, Moten M. Venodilation in Raynauds disease. Lancet. 1994; 343(8898): 678-679.
52. Freedman RR, Woodward S, Mayes M. Non-neural mediation of digital vasodilation during menopausal hot flushes. Gynecologic and Obstetric Investigation. 1994; 38(3): 206-209.
53. Freedman RR, Woodward S, Norton D. Circadian rhythm of menopausal hot flashes and body temperature in menopausal women. Advances in Pharmacological Sciences. 1994; 317-324. doi: http://dx.doi.org/10.1210/jcem.80.8.7629229
54. Freedman RR. Alternative therapies for menopausal symptoms. Menopause Management. 1994; 3(6): 24-27.
55. Woodward S, Freedman RR. The thermoregulatory effects of menopausal hot flashes on sleep. Sleep. 1994; 17(6): 497-501.
56. Freedman RR, Moten M, Migaly P, Mayes M. Cold-induced potentiation of α2-adrenergic vasoconstriction in primary Raynauds disease. Arthritis and Rheumatism. 1993; 36(5): 685-690.
57. Freedman RR, Keegan D, Rodriguez J, Galloway MP. Plasma catecholamine levels during temperature biofeedback training in normal subjects. Biofeedback and Self-Regulation. 1993; 18(2): 107-114.
58. Freedman RR, Sabharwal SC, Moten M, Migaly P. Local temperature modulates α1 and α2 -adrenergic vasoconstriction in man. American Journal of Physiology: Heart and Circulatory Physiology. 1992; 263(4 pt 2): H1197-1200.
59. Freedman RR. α2-adrenergic function in Raynauds disease. Archives of Internal Medicine. 1992; 152(9): 1929-1933.
60. Freedman RR, Woodward S. Behavioral treatment of menopausal hot flashes: Evaluation by ambulatory monitoring. American Journal of Obstetrics & Gynecology. 1992; 167(2): 436-439.
61. Freedman RR, Woodward S, Norton D. Laboratory and ambulatory monitoring of menopausal hot flushes: Comparison of symptomatic and asymptomatic women. Journal of Psychophysiology. 1992; 6(2): 162-166.
62. Freedman RR, Keegan D, Migaly P, Galloway MP, Mayes M. Plasma catecholamines during behavioral treatments for Raynauds disease. Psychosomatic Medicine. 1991; 53(4): 433-439.
63. Freedman RR. Physiological mechanisms of temperature biofeedback. Biofeedback and Self-Regulation.1991; 16(2): 95-115.
64. Freedman RR. Raynauds phenomenon, lack of neurological influence. British Journal of Rheumatology. 1990; 29(6): 492-493. doi: 10.1093/rheumatology/29.6.492
65. Freedman RR. Ambulatory monitoring of peripheral vascular disorders. Journal of Psychophysiology. 1990; 4: 303-311.
66. Freedman RR, Embury J, Migaly P, et al. Stress-induced desensitization of α2-adrenergic receptors in human platelets. Psychosomatic Medicine. 1990; 52(6): 624-630.
67. Freedman RR, Woodward S, Sabharwal SC. Alpha 2-adrenergic mechanism in menopausal hot flushes. Obstetrics and Gynecology. 1990; 76(4): 573-578.
68. Freedman RR. Raynauds syndrome. British Medical Journal. 1990; 300(6732): 1138.
69. Freedman RR, Woodward S. Provocation, detection and ambulatory monitoring of hot flashes. Annals of the New York Academy of Sciences. 1990; 592: 476-478.
70. Woodward S, Freedman RR. Increased menopausal hot flashes in slow wave sleep. Annals of the New York Academy of Sciences. 1990; 592: 479-480.
71. Freedman RR, Mayes M, Sabharwal S. Induction of vasospastic attacks despite digital nerve block in Raynauds disease and phenomenon. Circulation. 1989; 80(6): 859-862. doi: 10.1161/01.CIR.80.4.859
72. Freedman RR. Temperature biofeedback for Raynauds syndrome. Journal of the American Medical Association. 1989; 262(19): 2681. doi:10.1001/jama.1989.03430190061018.
73. Freedman RR. Laboratory and ambulatory monitoring of menopausal hot flashes. Psychophysiology. 1989; 26(5): 573-580.
74. Freedman RR, Mayes M, Sabharwal S. Digital nerve blockade in Raynauds disease. Circulation. 1989; 80(6): 1923-1924.
75. Freedman RR. Quantitative measurements of finger blood flow during temperature feedback. Psychophysiology. 1989; 26(4): 437-441.
76. Freedman RR, Sabharwal S, Desai N, Weing P, Mayes M. Increased alpha-adrenergic responsiveness in idiopathic Raynauds disease. Arthritis and Rheumatism. 1989; 33(1): 61-65.
77. Freedman RR, Sabharwal S, Ianni P, Desai N, Weing P, Mayes M. Non-neural beta-adrenergic vasodilating mechanism in temperature biofeedback. Psychosomatic Medicine. 1988; 50(4): 394-401.
78. Freedman RR, Morris, M, Norton D, Masselink D, Sabharwal SC, Mayes M. Physiological mechanism of digital vasoconstriction training. Biofeedback and Self-Regulation. 1988; 13(4): 299-305.
79. Freedman RR, Sabharwal C, Desai N. Sex differences in peripheral vascular adrenergic receptors. Circulation Research. 1987; 61(4): 581-585. doi: 10.1161/01.RES.61.4.581
80. Freedman RR. Long-term effectiveness of behavioral treatments for Raynauds disease. Behavior Therapy. 1987; 18: 387-399.
81. Freedman RR. Chronic insomniacs: replication of Monroes findings. Psychophysiology. 1987; 24(6): 721-722.
82. Freedman RR. EEG power spectra in sleep-onset insomnia. Electroencephalography and Clinical Neurophysiology. 1986; 63(5): 408-413.
83. Freedman RR, Ianni P, Ettedgui E, Puthezhath N. Ambulatory monitoring of panic disorder. Archives of General Psychiatry. 1986; 42: 244-248.
84. Freedman RR. Vascular reactivity and panic attacks. Journal of the American Medical Association. 1985; 2054(17): 2411. doi: 10.1001/jama.1985.03360170051020.
85. Freedman RR, Ianni P. Effects of general and thematically relevant stressors in Raynauds disease. Journal of Psychosomatic Research. 1985; 29(3): 274-280.
86. Freedman RR, Ianni P, Weing P. Behavioral treatment of Raynauds disease: long-term follow up. Journal of Consulting and Clinical Psychology. 1985; 53(1): 136. doi: http://dx.doi.org/10.1037/0022-006X.53.1.136
87. Freedman RR, Ianni P, Weing P. Behavioral treatment of Raynauds phenomenon in scleroderma. Journal of Behavioral Medicine. 1984; 7(4): 343-353.
88. Germaine L, Freedman RR. Behavioral treatment of menopausal hot flashes: evaluation by objective methods. Journal of Consulting and Clinical Psychology. 1984; 52(6): 1072-1079.
89. Freedman RR, Ianni P, Ettedgui E, Pohl R, Rainey JM. Psychophysiological factors in panic disorder. Psychopathology. 1984; 17(Suppl. 1): 66-73.
90. Rainey JM Jr, Frohman CE, Freedman RR, Pohl RB, Ettedgui E, Williams M. Specificity of the lactate model of anxiety. Psychopharmacology Bulletin. 1984; 20: 45-49.
91. Freedman RR. EEG power spectra of insomniacs and normal sleepers. Sleep Research. 1984; 12: 247.
92. Freedman RR. Physiological factors in insomnia and pseudo insomnia. Sleep Research. 1983; 11: 145.
93. Freedman RR. Cognitive hyperactivity not found in sleep-onset insomnia. Sleep Research. 1983; 11: 146.
94. Freedman RR, Ianni P. Role of cold and emotional stress in Raynauds disease and scleroderma. British Medical Journal Clinical Research Edition. 1983; 287(6404): 1499-1502.
95. Freedman RR, Ianni P. Self-control of digital temperature: physiological factors and transfer effects. Psychophysiology. 1983; 20(6): 682-689.
96. Freedman RR, Ianni P, Weing P. Behavioral treatment of Raynauds disease. Journal of Consulting and Clinical Psychology. 1983; 51(4): 539-549.
97. Freedman RR, Ianni P. Treatment of peripheral vascular disease. British Medical Journal Clinical Research Edition. 1983; 286(6383): 2063.
98. Freedman RR, Sattler HL. Physiological and psychological factors in sleep-onset insomnia. Journal of Abnormal Psychology. 1982; 91(5): 380-389.
99. Freedman RR, Czertko G. A comparison of twice weekly LAAM and daily methadone in employed heroin addicts. Drug and Alcohol Dependence. 1981; 8(3): 215-222. doi: http://dx.doi.org/10.1016/0376-8716(81)90064-8
100. Freedman RR, Lynn SJ, Ianni P, Hale PA. Biofeedback treatment of Raynauds disease and phenomenon. Biofeedback and Self-Regulation. 1981; 6(3): 355-365.
101. Freedman RR, Hauri P. Behavioral treatment of insomnia. Sleep Research. 1978; 7: 179.
102. Freedman RR, Hauri P, Coursey R, Frankel B. Behavioral treatment of insomnia: a collaborative study. Biofeedback and Self-Regulation. 1978; 3: 208-209.
103. Freedman RR, Hauri P. Biofeedback treatment of insomnia: an explanation of discrepant findings. Sleep Research. 1977; 6: 135.
104. Freedman RR, Papsdorf J. Biofeedback and progressive relaxation treatment of sleep-onset insomnia: a controlled all night investigation. Biofeedback and Self-Regulation. 1976; 1: 253-271.
105. Freedman RR. Psychological and physiological characteristics of sleep-onset insomniacs. Sleep Research. 1976; 5: 170.
106. Czertko G, Keegan J, Schooff K, Freedman RR. Primary propoxyphene dependence. Problems of Drug Dependence. 1976; 38: 26-30.
107. Freedman RR, Papsdorf J. Biofeedback and progressive relaxation treatment of sleep-onset insomnia. Sleep Research. 1975; 4: 216.
108. Freedman RR, Suter K. The development of feelings of detachment in elementary school children. Psychology in the Schools. 1969; 6: 83-88.
Ob/Gyn and Maternal Fetal Medicine
Department of Perinatology
EtlikZubeydeHanim Women’s Health and Teaching Hospital
• 1995-2001: Hacettepe UniversitySchool of Medicine, Ankara, Turkey
• 2002-2007: Hacettepe University, Ob/Gyn Residency
• 2011-2014: EtlikZubeydeHanim Women’s Health and Teaching Hospital, Maternal Fetal Medicine Fellowship
• 2014: Associate Professor, Ob/Gyn and Maternal Fetal Medicine
His research interests include: Fetal Echocardiography, Fetal Carditopography, IUGR, Multiple Pregnancies, and Pelvic Floor Disorders.
• International Society of Ultrasound in Obstetrics and Gynecology (ISUOG)
• Turkish Society of Obstetrics and Gynecology
1. Guven ES, Guven SS, Esin A, et al. Recurrent extraperitoneal low grade leiomyosarcoma with unusual localization. Eur J GynaecolOncol. 2004; 25(3): 381-383.
2. Ayhan A, Esin S, Guven S, Salman C, Ozyuncu O. The Manchester operation for uterine prolapse. Int J Gynaecol Obstet. 2006; 92(3): 228-233. doi: http://dx.doi.org/10.1016/j.ijgo.2005.12.002
3. Ayhan A, Dursun P, Gultekin M, Esin S. Pfannenstiel vs. midline incision for early stage endometrial carcinoma. Int J Gynaecol Obstet. 2006; 93(1): 67-69. doi: http://dx.doi.org/10.1016/j.ijgo.2005.12.029
4. Salman MC, Cil B, Esin S, Deren O. Late postpartum hemorrhage due to von Willebrand disease managed with uterine artery embolization. Obstet Gynecol. 2008; 111(2(2)): 573-575. doi: 10.1097/01.AOG.0000292091.68304.f1.
5. Esin S, Harmanli O. Large vesicovaginal fistula in women with pelvic organ prolapse: the role of colpocleisis revisited. IntUrogynecol J Pelvic Floor Dysfunct. 2008; 19(12): 1711-1713. doi: 10.1007/s00192-008-0636-5.
6. Esin S, Culha ZK, Kara OF, Yildirim H. A simple clinical maneuver to reduce laparoscopy-induced shoulder pain: a randomized controlled trial. Obstet Gynecol. 2008; 112(2(1)): 380. doi: 10.1097/AOG.0b013e318182cb6e.
7. Esin S, Yildirim H and Tanzer F. Laparoscopic management of a primary omental pregnancy after clomiphene induction. FertilSteril. 2009; 92(1): 392: e1-e3. doi: http://dx.doi.org/10.1016/j.fertnstert.2009.02.026
8. Ayhan A, Aksan G, Gultekin M, et al. Prognosticators and the role of lymphadenectomy in uterine leiomyosarcomas. Arch Gynecol Obstet. 2009; 280(1): 79-85. doi: 10.1007/s00404-008-0876-0
9. Harmanli OH, Tunitsky E, Esin S, Citil A, Knee A. A comparison of short-term outcomes between laparoscopic supracervical and total hysterectomy. Am J ObstetGynecol. 2009; 201(5): 536: e1-e7. doi: 10.1016/j.ajog.2009.07.048
10. Tunitsky EA, Ayaz CR, Esin S, Knee A, Harmanli O. Does surgical volume influence short-term outcomes of laparoscopic hysterectomy? Am J Obstet Gynecol. 2010; 203(1): 24: e1-e6. doi: 10.1016/j.ajog.2010.01.070
11. Esin S, Baser E, Kucukozkan T, Magden HA. Ovarian gonadoblastoma with dysgerminoma in a 15-year-old girl with 46, XX karyotype: case report and review of the literature. Arch Gynecol Obstet. 2012; 285(2): 447-451. doi: 10.1007/s00404-011-2073-9
12. Esin S, Salman MC, Ozyuncu O, Durukan T. Surgical outcome of transobturator tape procedure in obese and non-obese women. J ObstetGynaecol. 2011; 31(7): 645-649. doi: 10.3109/01443615.2011.597461
13. Jones K, Harmanli O, Robinson CA, Esin S, Citil A, Knee A. Effect of concomitant oophorectomy on the perioperative outcomes of laparoscopic hysterectomy. Int J Gynaecol Obstet. 2012; 117(1): 84-85. doi: 10.1016/j.ijgo.2011.11.007
14. Esin S, Tarim E, Abali H, Kardes O, Kocer EN, Alkan O. Management of precursor B-lymphoblastic lymphoma/leukaemia of thoracic spine in a pregnancy presenting with acute paraplegia. J ObstetGynaecol. 2012; 32(5): 485-486. doi: 10.3109/01443615.2012.683213
15. Esin S, Baser E, Cakir C, et al. Chocolate or orange juice for non-reactive non-stress test (NST) patterns: a randomized prospective controlled study. J Matern Fetal Neonatal Med. 2013; 26(9): 915-919. doi: 10.3109/14767058.2013.766698
16. Esin S, Baser E, Okuyan E, Kucukozkan T. Comparison of sublingual misoprostol withlidocaine spray for pain relief in office hysteroscopy: a randomized, double-blind, placebo-controlled trial. J Minim Invasive Gynecol. 2013; 20(4): 499-504. doi: 10.1016/j.jmig.2013.01.021
17. Baser E, Erkilinc S, Esin S, et al. Adnexal masses encountered during cesarean delivery. Int J Gynaecol Obstet. 2013. doi: 10.1016/j.ijgo.2013.06.015
18. Esin S, Gyimadu A, Atak Z, et al. Pretermpremature rupture of membranes in singleton vs twin pregnancies: The latencyperiods and the clinical outcomes revisited. J ObstetGynaecol. 2014; 34(7): 593-597. doi: 10.3109/01443615.2014.920781
19. Aydemir O, Kavurt S, Esin S, Kandemir O, Bas AY, Demirel N. Fetal echogenicbowel in association with Zellweger syndrome. J ObstetGynaecol Res. 2014; 40(6): 1799-1802. doi: 10.1111/jog.12379
20. Gabbay BR, Esin S, Baschat AA. Incorporating first trimester analytes topredict delivery of a large for gestational infant in women with impaired glucosetolerance. J Perinat Med. 2014. doi: 10.1515/jpm-2014-0041
21. Esin S, Sahin EG, Sari S, et al. Increase in preference for female obstetricians and gynecologists in job advertisements in Turkey. Int J Gynaecol Obstet. 2014; 126(1): 94. doi: 10.1016/j.ijgo.2014.02.006.
22. Esin S. Factors that increase reactivity during fetal nonstress testing. CurrOpinObstet Gynecol. 2014; 26(2): 61-66. doi: 10.1097/GCO.0000000000000050.
23. Yalvac S, Esin S, Kocak O, Yirci B, Kandemir O. Effect of body mass index onlatency periods after history-indicated cervical cerclage. Aust N Z J ObstetGynaecol. 2014; 54(2): 121-125. doi: 10.1111/ajo.12185
24. Harmanli O, Esin S, Knee A, Jones K, Ayaz R, Tunitsky E. Effect of obesity on perioperative outcomes of laparoscopic hysterectomy. J Reprod Med. 2013; 58(11-12): 497-503. doi: http://dx.doi.org/10.1016/j.jmig.2010.08.629
25. Esinler D, Dede H, Yalvac S, Yirci B, Esin S, Kandemir O. Concordant spinabifida in a twin pregnancy. J ObstetGynaecol. 2014; 34(3): 275-276. doi: 10.3109/01443615.2013.853728
26. Esin S, Yalvac S, Kandemir O. Are female fetuses more reactive when mothereats chocolate? J Matern Fetal Neonatal Med. 2014; 27(8): 862. doi: 10.3109/14767058.2013.877439
27. Aksakal SE, Kandemir O, Altınbas S, Esin S, Muftuoglu KH. Fetal tyhmus sizeas a predictor of histological chorioamnionitis in preterm premature rupture of membranes. J Matern Fetal Neonatal Med. 2014; 27(11): 1118-1122. doi: 10.3109/14767058.2013.850666
Department of Public Health
No. 22 Xinling Road
• (2013.09-2016.06) PhD, Biostatistics and Epidemiology, Sun Yat-Sen University, Guangdong, China
• (2010.09-2013.06) Master, Biostatistics and Epidemiology, Shantou University, Guangdong, China
• (2006.09-2010.06) Bachelor, Statistics, Southern Medical University, Guangdong Province, China
His research interestd include: Penalized likelihood estimation method, Machine learning, SAS and R programming.
• Member of the International Biometric Society
• (2014.11) Guangdong Province outstanding Masters degree thesis
• (2014.09) National Postgraduate Scholarships (Doctoral candidate)
• (2013.05) Outstanding graduate student (Shantou University)
1. Pi Guo, Fangfang Zeng, Xiaomin Hu, et al. Improved Variable Selection Algorithm Using a LASSO-Type Penalty, with an Application to Assessing Hepatitis B Infection Relevant Factors in Community Residents. PLoS One. 2015; 10(7): e0134151. doi: 10.1371/journal.pone.0134151
2. P Guo, Z L Huang, P Yu, et al. Trends in cancer mortality in China: An update. Ann Oncol. 2012; 23(10): 2755-2762. doi: 10.1093/annonc/mds069
3. Pi Guo, Ke Li. Trends in esophageal cancer mortality in China during 1987-2009: Age, period and birth cohort analyzes. Cancer Epidemiol. 2012; 36(2): 99-105. doi: 10.1016/j.canep.2011.12.003
4. Pi Guo, Xijin Xu, Binliang Huang, et al. Blood Lead Levels and Associated Factors among Children in Guiyu of China: A Population-Based Study. PLoS One. 2014; 9(8): e105470. doi: 10.1371/journal.pone.0105470
5. Pi Guo, Youxi Luo, Guoqin Mai, et al. Gene Expression Profile based Classification Models of Psoriasis. Genomics. 2014; 103(1): 48-55. doi: 10.1016/j.ygeno.2013.11.001
6. Pi Guo, Qin Zhang, Zhenli Zhu, et al. Mining Gene Expression Data of Multiple Sclerosis. PLoS One. 2014; 9(6): e100052. doi: 10.1371/journal.pone.0100052
7. Pi Guo, Shun-Li Shen, Qin Zhang, et al. Prognostic Evaluation of Categorical Platelet- based Indices Using Clustering Methods Based on the Monte Carlo Comparison for Hepatocellular Carcinoma. APJCP. 2014; 15(14): 5721-5727. Web site http://www.apocpcontrol.org/page/apjcp_issues_view.php?sid=Entrez:PubMed&id=pmid:25081692&key=2014.15.14.5721 Accessed
8. Zeng L, Guo P, Li JG, et al. Prognostic score models for survival of nasopharyngeal carcinoma patients treated with intensity-modulated radiotherapy and chemotherapy. Oncotarget. 2015; 6(36): 39373-3983. doi: 10.18632/oncotarget.5781
9. Zhang W, Du Z, Tang S, Guo P, Ye X, Hao Y. Syphilis in the economic center of South China: Results from a real-time, web-based surveillance program. BMC Infect Dis. 2015; 15: 318. doi: 10.1186/s12879-015-1072-z
10. Tian H, Qin W, Wu W, et al. Effect of Traditional Chinese Medicine on Chemotherapy-Induced Myelosuppression and Febrile Neutropenia in Breast Cancer Patients. Evid Based Complement Alternat Med. 2015; 736197. doi: 10.1155/2015/736197
11. Sun KY, Xu JB, Chen SL, et al. Novel immunological and nutritional-based prognostic index for gastric cancer. World J Gastroenterol. 2015; 21(19): 5961-5971. doi: 10.3748/wjg.v21.i19.5961
12. Xu X, Chen X, Zhang J, et al. Decreased Blood Hepatitis B Surface Antibody Levels Linked to E-waste Lead Exposure in Preschool Children. J Hazard Mater. 2015; 298: 122-128. doi: 10.1016/j.jhazmat.2015.05.020
13. Ding Z, Guo P, Xie F, et al. Impact of diurnal temperature range on mortality in a high plateau area in southwest China: A time series analysis. Sci Total Environ. 2015; 526: 358-365. doi: 10.1016/j.scitotenv.2015.05.012
14. Ding D, Su D, Li X, et al. Serum Levels of Monocyte Chemoattractant Protein-1 and All-Cause an Cardiovascular Mortality among Patients with Coronary Artery Disease. PLoS One. 2015; 10(3): e0120633. doi: 10.1371/journal.pone.0120633
15. Chen SL, Gwee KA, Lee JS, et al. Systematic review with meta-analysis: Prompt endoscopy as the initial management strategy for uninvestigated dyspepsia in Asia. Aliment Pharmacol Ther. 2015; 41(3): 239-252. doi: 10.1111/apt.13028
16. Shen SL, Fu SJ, Chen B, et al. Preoperative Aspartate Aminotransferase to Platelet Ratio is an Independent Prognostic Factor for Hepatitis B-Induced Hepatocellular Carcinoma After Hepatic Resection. Ann Surg Oncol. 2014; 21(12): 3802-3809. doi: 10.1245/s10434-014-3771-x
17. Zhu Z, Zhang J, Liu Y, Chen M, Guo P, Li K. Efficacy and toxicity of external-beam radiation therapy for localised prostate cancer: A network meta-analysis. Br J Cancer. 2014; 110(10): 2396-2404. doi: 10.1038/bjc.2014.197
18. Ma Q, Luo Y, Guo P, et al. Clinical Effects of Xinmailong Therapy in Patients with Chronic Heart Failure. Int J Med Sci. 2013; 10(5): 624-633. doi: 10.7150/ijms.5779
19. Xu XH, Peng XH, Yu P, et al. Neoadjuvant chemotherapy for resectable esophageal carcinoma: a meta-analysis of randomized clinical trials. Asian Pac J Cancer Prev. 2012; 13(1): 103-110. Web site http://www.apocpcontrol.org/page/apjcp_issues_view.php?sid=Entrez:PubMed&id=pmid:22502650&key=2012.13.1.103 Accessed
20. Zhang D, Li Z, Zhang W, et al. Hand- Washing: The Main Strategy for Avoiding Hand, Foot and Mouth Disease. Int J Environ Res Public Health. 2016; 13(6). pii: E610. doi: 10.3390/ijerph13060610
21. Zan Ding, Liujiu Li, Ruqin Wei, et al. Association of cold temperature and mortality and effect modification in the subtropical plateau monsoon climate of Yuxi. China. Environ Res. 2016; 150: 431-437. doi: 10.1016/j.envres.2016.06.029
Consultant Obstetrician and Gynaecologist
University of Malta
Msida MSD 2080, Malta
• St. Aloysius College [Malta], University of Malta, University of Warwick [U.K.]. Furthered specialised medical training in British N.H.S South-West Hertsfordshire Region and the Cliniques Universitaires St. Raphael/Gasthuisberg [Leuven, Belgium]
• MD, Medical Doctorate [University of Malta, 1986]
• MRCOG, Member of the Royal College of Obstetricians & Gynaecologists [U.K., 1992]
• MRCPI, Member of the Royal College of Physicians of Ireland [Ireland, 1994]
• MIOG, Member of the Institute of Obstetricians & Gynaecologists [Ireland, 1992]
• PhD, Doctor of Medical Education [Warwick, U.K., 2002]
• FRCOG, Fellow of the Royal College of Obstetricians & Gynaecologists [U.K., 2004]
• FRCPI, Fellow of the Royal College of Physicians of Ireland [Ireland, 2009], Accreditation Certificate in Obstetrics-Gynaecology [S.A.C., Malta, 2003]
• Deputy Chairman Department of Obstetrics and Gynaecology, Mater Dei Hospital, Malta
• Consultant Obstetrician-Gynaecologist, Department of Health, Malta
• Associate Professor in the Department of Obstetrics & Gynaecology, Faculty of Medicine & Surgery, University of Malta
• Member of the Patient Safety and Quality Improvement Team (PaSQIT)-Mater Dei Hospital
• Founder member of SANDS Malta (Stillbirth and Neonatal Death Society), the ENDO Support Group (Endometriosis Malta Society), the Malta Peripheral Neurosensory Group
• Scientific Officer of Malta Osteoporosis Society and Malta College of Obstetricians and Gynaecologists
His research interests include: Gynaecological endocrinology, Connective tissue changes with menopause & climacteric, Bone metabolism, Endometriosis and menstrual disorders, Feto-maternal medicine, Premature labour, Shoulder dystocia, Caesarean section, Patient safety and quality improvement.
AWARDS AND HONORS
• 25th F.I.G.O Conference held in Copenhagen (1997)-Best basic science poster entitled carotid artery wall thickness in hormone treated and untreated postmenopausal women
• 4th European Congress on the menopause held in Vienna (1998)-Prize for Best Scientific Presentation. Entitled carotid artery wall thickness in hormone treated and untreated postmenopausal women and women on oestradiol implants
• Maltese Civil Service (1998) Token of appreciation for voluntary work supporting bereaved parents and founding SANDS (Stillbirth and Neonatal Death Society founded in 1994)
• Royal college of obstetricians and gynaecologists representative committee prize at the 5th Medical School Conference (2003) for best presentation entitled-intervertebral disc height in hormone treated and untreated postmenopausal women
• 30th British congress of obstetrics and gynaecology held in Glasgow (2004). Best poster prize-skin thickness and bone density-a screening test for osteoporotic fractures
• 6th Maltese Medical School Conference (2006) Best oral presentation entitled low intervertebral disc height in women with osteoporotic vertebral fractures compared to menstrual, hormone treated and untreated postmenopausal women
• 7th Maltese Medical School Conference (2009) Best poster presentation entitled a 30 year review on traumatic shoulder dystocia in the Maltese Islands (as Co-worker)
• COGI Congress on Controversies in Obstetrics and Gynaecology (2011) Best young scientist award to Nicholas Felice (co-author) entitled low intervertebral disc height in women with osteoporotic vertebral fractures compared to menstrual, hormone treated and untreated postmenopausal women
• 8th Maltese Medical School Conference (2012) Best oral presentation entitled thermographic studies of the pregnant uterus
• EBCOG Congress (2014) (European Board and College of Obstetricians and Gynaecologists) poster prize thermographic studies of the pregnant uterus
1. Muscat Baron Y. Why did humans develop a large brain think? University of Malta Journal. 2012; 2: 32-37.
2. Muscat Baron Y. Bipedalism and Obstetrics-An exercise in Darwinian Medicine. Proceedings of the first humanities and medical sciences joint meeting. 2012; 1: 10.
3. Muscat Baron Y, Craus J, Camilleri Agius R, Brincat M. Synergistic effect on the treatment of menorhagia by endometrial biopsy followed by contemporaneous insertion of levonorgestrel intrauterine system. Gynaecological Endocrinology. 2012; 28: 694-698. doi: 10.3109/09513590.2011.650932
4. Muscat Baron Y. Clinical practice guideline for antenatal surveillance and indications for induction of labour in the post-dates pregnancy. Department of Obstetrics and Gynaecology, UMMS, Malta 2011.
5. Muscat Baron Y, Brincat M, Galea R. Iliac vessel wall thickness in menstrual women, Hormone treated women and untreated women. Gynaecological Endocrinology. 2012; 28: 409-412. doi: 10.3109/09513590.2011.632790
6. Muscat Baron Y, Dingli M, Camilleri Agius R, Calleja N. Gastro-intestinal symptoms and dietary intolerance in women with endometriosis. Giornale Ostericia e Ginecologia. 2012; 2: 252-256.
7. Muscat Baron Y. A history of the menopause. UMMS, Malta 2013.
8. Muscat Baron Y. Improving the efficiency of the antenatal and gynaecological outpatients department at Mater Dei Hospital. 2013.
9. Muscat Baron Y. Hospital influenza initiative. Report to Patient Safety and Quality Improvement Team. 2014.
10. Muscat Baron Y, Hollins-Martin C, van den Akker, Martin C, Preedy V. Dietary intolerance in women diagnosed with endometriosis. Handbook of diet and nutrition in the menstrual cycle, conception, and fertility. Chapter 28. King’s College, London: Wageningen Academic Publishers; 2014: 449-470.
11. Muscat Baron Y, Hollins-Martin C, van den Akker, Martin C, Preedy V. Gastro-Intestinal symptoms in women with endometriosis. Handbook of Diet and Nutrition in the menstrual cycle, conception, and Fertility. Chapter 28. King’s College, London, UK: Wageningen Academic Publishers. 2014: 471-488.
12. Muscat Baron Y, Shaeffer E, Curley M. Functional, Gastrointestinal symptoms in women with pelvic endometriosis: Chapter in book entitled Dyspepsia. Chapter 9. 2014: 169-182.
13. Welch TM, Muscat Baron Y. Menorrhagia: Risk Factors, Diagnosis and Treatment. Chapter 1. 2015: 1-31.
14. Muscat Baron Y. Skin thickness and bone density changes in treated and untreated postmenopausal women and in women who have sustained osteoporotic fractures. Andrology and Gynaecology. 2015; 3: 3.
15. Muscat Baron Y. The effect of dexamethasone on the pre-eclamptic process. Critical Obstetrics and Gynaecology. 2015; 2: 1. doi: 10.21767/2471-9803.100010
16. Muscat Baron Y. Ovarian physiology and the short-term effects of the menopause. Andrology and Gynaecology. 2016; 4: 1.
17. Muscat Baron Y. Does the 10-15% Caesarean section rate threshold endorsed by the world health organization in 1985 still apply to modern obstetrics in developed countries? The ideal caesarean section rate and the stillbirth and the neonatal death perspective editorial critical care. Obstetrics and Gynaecology. 2016; 2: 13.
18. Muscat Baron Y. The case for extending hospital visiting hours. Health Systems and Policy Research. 2016; 3: 24.
19. Muscat Baron Y. Atherosclerosis and the menopause. Androl Gynecol Curr Res. 2016; S1.