Editorial Board


Gastro - Open Journal

Shreyas Saligram, MD, MRCP

Department of of Interventional Gastroenterology
Moffitt Cancer Center
Department of Gastroenterology
Kansas University Medical Center
235 Ward Parkway, Apt 307
Kansas City, MO-64112, USA

BiographyResearch InterestScientific ActivitiesPublications

Dr. Saligram graduated from Sri Devaraj Urs Medical School in India in 2003. Thereafter, he moved to England and completed his residency in Internal Medicine from Royal Liverpool University Hospital. During his sub-specialization training in Gastroenterology from Poole Hospital of Wessex Deanery, he received his membership from the prestigious Royal College of Physicians (MRCP) in March, 2009.
On receiving his MRCP in England, Dr. Saligram moved to USA in July, 2009 and underwent training in Internal Medicine from University of Pittsburgh Medical Center. He started his Sub-specialization in Gastroenterology from Kansas University Medical Center and has decided to pursue a career in Interventional Gastroenterology in Moffitt Cancer Center.
During his training, he developed an interest in academic medicine. He has presented in various international conferences like Digestive Disease Week and American College of Gastroenterology. He has several published articles in high impact journals including New England Journal of Medicine.
The published articles are of different kinds which range from original articles, review articles, newspaper articles and book chapters.

His research interest include: Pathogenesis of Barretts esophagus, Endoscopic therapy of Barretts esophagus like Endoscopic Mucosal Resection, Radio Frequency Ablation and also advanced imaging studies like Narrow band imaging of the gastrointestinal tract evaluating Barretts esophagus and colon polyps.

AWARDS


• (2010) 1st prize for poster presentation by American College of Physicians
• (2010) 3rd prize for poster presentation by Pennsylvania Society of Gastroenterology


PROFESSIONAL SOCIETIES AND AFFILIATIONS


• (2013) American Society for Gastrointestinal Endoscopy
• (2013) American College of Gastroenterology
• (2009) American College of Physicians
• (2009) Royal College of Physicians, UK

ARTICLES PUBLISHED


1. Saligram S, Rastogi A. Tools for Polyp Histology Prediction. Gastrointestinal Endoscopy Clinics of North America. 2015; 25(2): 261-286. doi: 10.1016/j.giec.2014.11.009
2. Alahdab F, Saligram S. Acute colonic pseudo-obstruction. N Engl J Med. 2015; 372(4): e5. doi: 10.1056/NEJMicm1311399
3. Bielefeldt K, Saligram S, Zickmund SL, Dudekula A, Olyaee M, Yadav D. Cholecystectomy for biliary dyskinesia: how did we get there?. Digestive diseases and sciences. 2014; 59(12): 2850-2863. doi: 10.1007/s10620-014-3342-9
4. Saligram S, McGrath K. The safety of a strict wire-guided dilation protocol for eosinophilic esophagitis. European journal of gastroenterology & hepatology. 2014; 26(7): 699-703. doi: 10.1097/MEG.0000000000000103
5. Alahdab F, Saligram S. Gastrointestinal amyloidosis and multiple myeloma. J Gen Intern Med. 2015; 30(2): 261-262. doi: 10.1007/s11606-014-2897-7
6. Saligram S, Vennalaganti P, Sharma P. Endoscopic eradication therapy for Barretts esophagus. Gastroenterology and Endoscopy News. 2014.
7. Saligram S, Bielefeldt K. The two sides of Opioids in Cyclical Vomiting Syndrome. North American Journal of Medical Sciences. 2014; 6 (3): 114-118. doi: 10.4103/1947-2714.128472.
8. Saligram S, Fan F, Oropeza-Vail M, Gholami P, Olyaee M. Accuracy of endoscopic ultrasound guided fine needle aspiration in diagnosing solid pseudopapillary tumor. North American Journal of Medical Sciences. 2013; 5(12): 716-720. doi: 10.4103/1947-2714.123270
9. Saligram S, Vennalaganti P, Sharma P. Endoscopic eradication therapy for Barretts esophagus. Gastroenterology and Endoscopy News. 2013.
10. Saligram S, Chennat J, Hu H, Davison JM, Fasanella KE, McGrath K. Endotherapy for superficial adenocarcinoma of the esophagus: an American experience. Gastrointest Endosc. 2013; 77(6): 872-876. doi: 10.1016/j.gie.2013.01.014
11. Saligram S, Lo D, Saul M, Yadav D. Analyses of hospital administrative data that use diagnosis codes overestimate the cases of acute pancreatitis. Clin Gastroenterol Hepatol. 2012; 10(7): 805-811.e1. doi: 10.1016/j.cgh.2012.03.025
12. Saligram S, Williams EJ, Masding MG. Raised liver enzymes in newly diagnosed Type 2 diabetes are associated with weight and lipids, but not glycaemic control. Indian J Endocrinol Metab. 2012; 16(6): 1012-1014. doi: 10.4103/2230-8210.103027
13. Nathaniel S, Saligram S, Innasimuthu AL. Aortic stenosis: An update. World J Cardiol. 2010; 2(6): 135-139. doi: 10.4330/wjc.v2.i6.135
14. Saligram S, Madan R, Olyaee M. Endoscopic ultrasound diagnosis of perianal rhabdomyosarcoma. Gastro Open J. 2015; 1(3): 71-73. doi: 10.17140/GOJ-1-112
15. Saligram S, Levintha DJ, Bielefeldt K. Coalescent cyclical vomiting: a manifestation of narcotic bowel syndrome?. Gastro Open J. 2015; 1(5): 111-113. doi: 10.17140/GOJ-1-119
16. Saligram S, Desai M, Baidoo L. Management of inflammatory bowel diseases in jehovah’s witness. Gastro Open J. 2015; 1(5): 114-118. doi: 10.17140/GOJ-1-120


BOOK CHAPTERS PUBLISHED


1. Saligram S, Rastogi A. Tools for Polyp Histology Prediction. Gastrointestinal Endoscopy Clinics of North America. 2015; 25(2): 261-286. doi: 10.1016/j.giec.2014.11.009

Hiroyuki Yoshida, PhD

Director of 3D Imaging Research
Department of Radiology
Massachusetts General Hospital
Associate Professor of Radiology
Harvard Medical School
USA

BiographyResearch InterestScientific ActivitiesPublications

Dr. Yoshida received his BS and MS degrees in physics and a PhD degree in Information Science from the University of Tokyo, Japan. He previously held an Assistant Professorship in the Department of Radiology at the University of Chicago. He was a Tenured Associate Professor when he left the University and joined the Massachusetts General Hospital (MGH) and Harvard Medical School (HMS), where he is currently the Director of 3D Imaging Research in the Department of Radiology, MGH and an Associate Professor of Radiology at HMS. He also received two industrial awards on his work on system developments: 2012 Innovation Award from Microsoft Health Users Group and Partners in Excellence award from Partners Health Care. He is an author or co-author of more than 170 journal and proceedings papers and 16 book chapters, an author, co-author, or editor of 14 books, and inventor and co-inventor of seven issued patents.

His research interest include: Computer-aided diagnosis, Quantitative imaging and Imaging biomarkers for the diagnosis of abdominal cancers.

HONORS AND PRIZES


• (2000) Cum Laude Radiological Society of North America
• (2002) Honorable Mention SPIE Medical Imaging
• (2002) Excellence in Design Radiological Society of North America
• (2004) Certificate of Merit Radiological Society of North America
• (2006) Certificate of Merit Radiological Society of North America
• (2008) Certificate of Merit Radiological Society of North America
• (2009) Cum Laude Radiological Society of North America
• (2009 Editors Recognition Award for Reviewing with Distinction Radiological Society of North America
• (2010) Excellence in Design Radiological Society of North America
• (2011) Magna Cum Laude Radiological Society of North America
• (2011) Certificate of Merit Radiological Society of North America
• (2012) Innovation Award Microsoft Health Users Group
• (2012) Partners in Excellence Partners HealthCare System
• (2014) Gold medal, CyPos Award Japan Radiology Congress
• (2015) Honorable Mention SPIE Medical Imaging


PROFESSIONAL SOCIETIES/MEMBERSHIPS


• (1989) Information Processing Society of Japan (IPSJ), Member
• (1989) The Institute of Electronics, Information and Communication Engineers (IEICE), Member
• (1990) Association for Computing Machinery (ACM), Member
• (1994) International Society for Optical Engineering (SPIE), Member
• (1996) Institute of Electrical and Electronics Engineers (IEEE), Member
• (1996) American Association on Physicists in Medicine (AAPM), Member
• (2005) Radiological Society of North America (RSNA), Member
• (2005) American Roentgen Ray Society (ARRS), Member
• (2008) International Society and Conference Series on Medical Image Computing and Computer-Assisted Intervention, Member
• (2009) Japanese CT Colonography Society, President

PEER REVIEWED PUBLICATIONS IN PRINT OR OTHER MEDIA


1. Saito S, Yoshida H, Kunii T. The CrossoverNet LAN system using an intelligent head end. IEEE Transactions on Computers. 1989; 38: 1076-1085. doi: 10.1109/12.30863
2. Yoshida H. Network protocol specification with a visual language. Academic Report of TIP. 1989; 12: 26-50.
3. Yoshida H. Face image synthesis with distributed computing. Academic Report of TIP. 1990; 13: 10-19.
4. Yoshida H, Takahara T. A production system based on the distributed artificial intelligence. Academic Report of TIP. 1991; 14: 13-21.
5. Muto K, Ohno H, Yoshida H, Tsuda M. High speed 3 dimensional reconstruction of medical images based on the optimized granularity. Medical Imaging Technology. 1992; 10: 261-262.
6. Ohno H, Muto K, Yoshida H, Tsuda M. High speed image generation based on the loosely coupled distributed system. Academic Report of TIP. 1993; 15: 10-20.
7. Yoshida H, Doi K, Nishikawa RM, Muto K, Tsuda M. Application of the wavelet transform to automated detection of clustered microcalcifications in digital mammograms. Academic Report of TIP. 1994; 16: 24-37.
8. Muto K, Yoshida H, Tsuda M. Parallelization of the wavelet transform using a loosely coupled distributed system. Academic Report of TIP. 1995; 17: 38-49.
9. Yoshida H, Doi K. Fundamentals of wavelet transform and its applications to computer aided diagnosis I. Japanese Journal of Radiological Technology. 1996; 52: 18-26.
10. Yoshida H, Doi K. Fundamentals of wavelet transform and its applications to computer aided diagnosis II. Japanese Journal of Radiological Technology. 1996; 52: 374-383.
11. Yoshida H, Doi K, Nishikawa RM, Giger ML, Schmidt RA. An improved CAD scheme using wavelet transform for detection of clustered microcalcifications in digital mammograms. Academic Radiology. 1996; 3: 621-627.
12. Zhang W, Yoshida H, Nishikawa RM, Doi K. Optimally weighted wavelet transform based on supervised training for detection of microcalcifications in digital mammograms. Medical Physics. 1998; 25: 949-956.
13. Anastasio MA, Yoshida H, Nishikawa RM, Doi K. A genetic algorithm based method for optimizing the performance of a computer aided diagnosis scheme for detection of clustered microcalcifications in mammograms. Medical Physics. 1998; 25: 1559-1566.
14. Yoshida H. Matching pursuit with optimally weighted wavelet packets for extraction of microcalcifications in mammograms. Applied Signal Processing (Special issue on biomedical signal processing). 1999; 5: 127-141.
15. Nakamura K, Yoshida H, Engelmann R, et al. Computerized analysis of the likelihood of malignancy in solitary pulmonary nodules using artificial neural networks. Radiology. 2000; 214: 823-830. doi: 10.1148/radiology.214.3.r00mr22823
16. Li Q, Kantsuragawa S, Ishida T, et al. Contralateral subtraction: a novel technique for detection of asymmetric abnormalities on digital chest radiographs. Medical Physics. 2000; 27: 47-55.
17. Yoshida H, Keserci B. Bayesian wavelet snake for computer aided diagnosis of lung nodules. Journal of Integrated Computer Aided Engineering (Special issue on industrial applications of the wavelet transform). 2000; 7: 253-269.
18. Masutani Y, Yoshida H, MacEneaney P, Dachman AH. Automated segmentation of colonic walls for computerized detection of polyps in CT colonography. Journal of Computer Assisted Tomography. 2001; 25: 629-638.
19. Yoshida H, Näppi J. Three dimensional computer aided diagnosis scheme for detection of colonic polyps. IEEE Transactions on Medical Imaging. 2001; 20: 1261-1274. doi: 10.1109/42.974921
20. Yoshida H, Masutani Y, MacEneaney P, Rubin D, Dachman AH. Computerized detection of colonic polyps at CT colonography on the basis of volumetric features: pilot study. Radiology. 2002; 222: 327-336. doi: 10.1148/radiol.2222010506
21. Näppi J, Yoshida H. Automated detection of polyps in CT colonography: evaluation of volumetric features for reduction of false positives. Academic Radiology. 2002; 9: 386-397.
22. Yoshida H, Näppi J, MacEneaney P, Rubin D, Dachman AH. Computer-aided diagnosis scheme for the detection of polyps in CT colonography. RadioGraphics. 2002; 22: 963-979. doi: 10.1148/radiographics.22.4.g02jl16963
23. Yoshida H. Registration methods for computer aided diagnosis schemes. Medical Imaging Technology. 2002; 20: 23-28.
24. Yoshida H. Screening of colon cancer with virtual colonoscopy: current status and future potential. Stomach and Intestine. 2002; 37: 1379-1386.
25. Näppi J, Dachman AH, MacEneaney P, Yoshida H. Knowledge guided automated segmentation of colon for computer-aided detection of polyps in CT colonography. Journal of Computer Assisted Tomography. 2002; 26: 493-504.
26. Keserci B, Yoshida H. Computerized detection of pulmonary nodules in chest radiographs based on morphological features and wavelet snakes. Medical Image Analysis. 2002; 6: 431-447. doi: 10.1016/S1361-8415(02)00064-6
27. Yoshida H. Multiscale edge guided wavelet snake model for delineation of pulmonary nodules in chest radiographs. Journal of Electronic Imaging. 2003; 12: 69-80. doi: 10.1117/1.1526496
28. Yoshida H. CAD for the detection of colonic polyps in CT colonography. Medical Imaging Technology. 2003; 21: 34-40.
29. Näppi J, Yoshida H. Feature guided analysis for reduction of false positives in CAD of polyps for CT colonography. Medical Physics. 2003; 30: 1592-1601.
30. Yoshida H, Casalino D, Keserci B, Coskun A, Ozturk O, Savranlar A. Wavelet packet based texture analysis for differentiation between benign and malignant liver tumors in ultrasound images. Physics in Medicine and Biology. 2003; 48: 3735-3753.
31. Dachman AH, Glick S, Yoshida H. CT colonography and colon cancer screening. Seminars in Roentgenology. 2003; 38: 54-64.
32. Yoshida H. Local contralateral subtraction based on bilateral symmetry of chest for computerized detection of pulmonary nodules. IEEE Transactions on Biomedical Engineering. 2004; 51: 778-789. doi: 10.1109/TBME.2004.824136
33. Näppi J, Frimmel H, Dachman A, Yoshida H. Computerized detection of colorectal masses in CT colonography based on fuzzy merging and wall-thickening analysis. Medical Physics. 2004; 31: 860-872.
34. Yoshida H, Dachman AH. Computer-aided diagnosis for CT colonography. Seminars in Ultrasound, CT and MRI. 2004; 25: 419-431.
35. Dachman AH, Schumm P, Heckel B, Yoshida H, LaRiviere P. Effect of reconstruction kernel on conspicuity of polyps in CT colonography. AJR American Journal of Roentgenology. 2004; 183: 1349-1353.
36. Frimmel H, Näppi J, Yoshida H. Fast and robust computation of colon centerlines in CT colonography. Medical Physics. 2004; 31: 3046-3056.
37. Yoshida H. CT colonography with multi-detector CT: feasibility for screening of early colorectal cancers. Early Colorectal Cancer. 2004; 8: 507-514.
38. Yoshida H, Dachman AH. CAD techniques, challenges, and controversies in computed tomographic colonography. Abdominal Imaging. 2005; 30: 26-41. doi: 10.1007/s00261-004-0244-x
39. Näppi J, Frimmel H, Yoshida H. Virtual endoscopic visualization of the colon by shape scale signatures. IEEE Transactions on Information Technology in Biomedicine. 2005; 9: 120-131.
40. Näppi J, Okamura A, Frimmel H, Dachman AH, Yoshida H. Region-based supine-prone correspondence for the reduction of false-positive CAD polyp candidates in CT colonography. Academic Radiology. 2005; 12: 695-707. doi: 10.1109/TITB.2004.837834
41. Frimmel H, Näppi J, Yoshida H. Centerline based segmentation of colon in CT colonography. Medical Physics. 2005; 32: 2665-2672.
42. Perumpillichira JJ, Yoshida H, Sahani DV. Computer-aided detection for virtual colonoscopy. Cancer Imaging. 2005; 23: 11-16. doi: 10.1102/1470-7330.2005.0016
43. Suzuki K, Yoshida H, Näppi J, Dachman AH. Massive-training artificial neural network (MTANN) for reduction of false positives in computer-aided detection of polyps: suppression of rectal tubes. Medical Physics. 2006; 33: 3814-3824.
44. Dachman AH, Dawson DO, Lefere P, et al. Comparison of routine and unprepped CT colonography augmented by low fiber diet and stool tagging: a pilot study. Abdominal Imaging. 2007; 32: 96-104. doi: 10.1007/s00261-006-9044-9
45. Cai W, Harris GJ, Yoshida H. Computation of vesselness in CTA images for fast and interactive vessel segmentation. International Journal of Image and Graphics. 2007; 1: 159-176. doi: 10.1142/S021946780700260X
46. Näppi J, Yoshida H. Fully automated three-dimensional detection of polyps in fecal-tagging CT colonography. Academic Radiology. 2007; 14: 287-300. doi: /10.1016/j.acra.2006.11.007
47. Yoshida H, Näppi J. CAD in CT colonography without and with fecal tagging: progress and challenges. Journal of Computerized Medical Imaging and Graphics. 2007; 31: 267-284. doi: 10.1016/j.compmedimag.2007.02.011
48. Cai W, Holalkere N-S, Harris GJ, Sahani D, Yoshida H. Dynamic-threshold level set method for volumetry of porcine kidney in CT images: in-vivo and ex-vivo assessment of the accuracy of volume measurement. Academic Radiology. 2007; 14: 890-896. doi: 10.1016/j.acra.2007.03.005
49. Yoshida H. Analysis of the effect of computer-aided diagnosis and electronic cleansing on screening CT colonography. Early Colorectal Cancer. 2008; 12: 143-154.
P50. Suzuki K, Yoshida H, Näppi J, Armato III SG, Dachman AH. Mixture of expert 3D massive-training ANNs for reduction of multiple types of false positives in CAD for detection of polyps in CT colonography. Medical Physics. 2008; 35: 694-703. doi:10.1118/1.2829870
51. Cai W, Zalis ME, Näppi J, Yoshida H. Structure-analysis method for electronic cleansing in cathartic and non-cathartic CT colonography. Medical Physics. 2008; 35: 3259-3277. doi:
52. Näppi J, Yoshida H. Adaptive correction of the pseudo-enhancement of CT attenuation for fecal-tagging CT colonography. Medical Image Analysis. 2008; 12: 413-426. doi: 10.1016/j.media.2008.01.001
53. Yoshida H. Influence of computer-aided detection of polyps on screening of colon cancer with CT colonography. IEICE Transactions on Information and Systems. 2008; J91-D: 1730-1743.
P54. Nagata K, Okawa T, Honma A, Endo S, Kudo SE, Yoshida H. Full-laxative versus minimum-laxative fecal-tagging CT colonography using 64-detector row CT: prospective blinded comparison of diagnostic performance, tagging quality, and patient acceptance. Academic Radiology. 2009; 16: 780-789. doi: 10.1016/j.acra.2008.12.027
55. Nagata K, Yoshida H. Effect of screening strategies for colorectal cancer with CT colonography. Intestine. 2009; 13: 119-127.
56. Nagata K, Singh AK, Jagtiani MC, et al. Comparative evaluation of the quality of fecal-tagging in CT colonography-barium vs. iodinated oral contrast agent. Academic Radiology. 2009; 16: 1393-1399.
57. Cai W, Kassarjian A, Bredella MA, et al. Tumor burden in patients with neurofibromatosis types 1 and 2 and schwannomatosis: determination on whole-body MR images. Radiology. 2009; 250: 665-673. doi: 10.1148/radiol.2503080700
58. Tsagaan B, Näppi J, Yoshida H. Nonlinear regression-based method for pseudo-enhancement correction in CT colonography. Medical Physics. 2009; 36: 3596-606. doi: 10.1118/1.3147201
59. Näppi J, Yoshida H. Virtual tagging for laxative-free CT colonography. Medical Physics. 2009; 36: 1830-1838. doi: 10.1118/1.3113893
60. Cai W, Tabbara M, Takata N, et al. MDCT for automated detection and measurement of pneumothoraces in trauma patients. AJR Am J Roentgenol. 2009; 192: 830-836. doi: 10.2214/AJR.08.1339
61. Awad M, Motai Y, Näppi J, Yoshida H. A clinical decision support framework for incremental polyps classification in virtual colonoscopy. Algorithms. 2010; 3: 1-20. doi: 10.3390/a3010001
62. Cai W, Yoshida H, Zalis M, Näppi J, Harris G. Electronic cleansing for non-cathartic CT colonography - A structure-analysis scheme. Radio Graphics. 2010; 3: 585-602. doi: 10.1148/rg.303095154
63. Cai W, Lee J-G, Zalis M, Yoshida H. Mosaic decomposition: an electronic cleansing method for inhomogeneously tagged regions in non-cathartic CT colonography. IEEE Transactions on Medical Imaging. 2011; 30: 559-574. doi: 10.1109/TMI.2010.2087389
64. Cai W, Lee EY, Vij A, Mahmood SA, Yoshida H. MDCT for computerized volumetry of pneumothoraces in pediatric patients. Academic Radiology. 2011; 18: 315-323.
65. Xu Y, Cai W, Näppi J, Yoshida H. Fecal-tagging CT colonography with structure-analysis electronic cleansing for detection of colorectal flat lesions. European Journal of Radiology. 2012; 81: 1712-1716.
66. Zalis ME, Blake MA, Cai W, et al. Diagnostic accuracy of laxative-free computed tomographic colonography for detection of adenomatous polyps in asymptomatic adults: a prospective evaluation. Annals of Internal Medicine. 2012; 156: 692-702. doi: 10.7326/0003-4819-156-10-201205150-00005

OTHER PEER-REVIEWED PUBLICATIONS


67. Cai W, Lee JG, Fikry K, Yoshida H, Novelline R, de Moya M. MDCT quantification is the dominant parameter in decision-making regarding chest tube drainage for stable patients with traumatic pneumothorax. Computerized Medical Imaging and Graphics. 2012; 36: 375-386.
68. Motai Y, Yoshida H. Principal composite kernel feature analysis: Data-dependent kernel approach. IEEE Transactions on Knowledge and Data Engineering. 2013; 25: 1863-1875. doi: 10.1109/TKDE.2012.110
69. Cai W, Kim S-H, Lee J-G, Yoshida H. Dual-energy electronic cleansing for fecal-tagging CT colonography. RadioGraphics. 2013; 33: 891-912. doi: 10.1148/rg.333125039
70. Cai W, Zhang D, Shirai Y, Lee J-G, Kim S-H, Yoshida H. Dual-energy index value of luminal air in fecal-tagging CT colonography: Findings and impact on electronic cleansing. Journal of Computer Assisted Tomography. 2013; 37: 183-194. doi: 10.1097/RCT.0b013e31827bc266
71. Huo Z, Summers RM, Paquerault S, et al. Quality assurance and training procedures for computer-aided detection and diagnosis systems in clinical use. Medical Physics. 2013; 40: 077001. doi: 10.1118/1.4807642.
72. Petrick N, Sahiner B, Armato SG 3rd, et al. Evaluation of computer-aided detection and diagnosis systems. Medical Physics. 2013; 40: 087001. doi: 10.1118/1.4816310
73. Hayano K, Lee SH, Yoshida H, Zhu AX, Sahani DV. Fractal analysis of CT perfusion images for evaluation of vascular heterogeneity change induced by antiangiogenic treatment and prediction of survival in hepatocellular carcinoma. Academic Radiology. 2014; 21: 654-60.
74. Hayano K, Yoshida H, Zhu AX, Sahani DV. Fractal analysis of tumor enhancement on contrast-enhanced computed tomography for the prediction of clinical outcome in HCC patients treated with sunitinib. Dig Dis Sci. 2014; 59: 1996-2003. doi: 10.1007/s10620-014-3064-z.
75. Cai W, Lee JG, Zhang D, Kim SH, Zalis M, Yoshida H. Electronic cleansing in dual-energy fecal-tagging CT colonography based on material decomposition and virtual colon tagging. IEEE Transactions on Biomedical Engineering. 2015; 62: 754-765. doi: 10.1109/TBME.2014.2364837


OTHER PEER-REVIEWED PUBLICATIONS


1. Yoshida H, Doi K, Nishikawa RM. Automated detection of clustered microcalcifications in digital mammograms using wavelet transform techniques. Proc SPIE. 1994; 2167: 868-886. doi: 10.1117/12.175126
2. Yoshida H, Xu X, Kobayashi T, Giger ML, Doi K. Computer aided diagnosis scheme for detecting pulmonary nodules using wavelet transform. Proc SPIE. 1995; 2434: 621-626.
3. Yoshida H, Zhang W, Cai W, Doi K, Nishikawa RM, Giger ML. Optimizing wavelet transform based on supervised learning for detection of microcalcifications in digital mammograms. Proc IEEE International Conference on Image Processing (ICIP95). 1995: 152-155.
4. Yoshida H, Doi K, Nishikawa RM, Giger ML. Computer aided diagnosis in mammography: Detection of clustered microcalcifications based on multiscale edge representation. Proc CAR—Computer Assisted Radiology. 1996: 390-395.
5. Katsuragawa S, Doi K, MacMahon H, Ishida T, Yoshida H. CAD schemes for detection and characterization of interstitial disease in digital chest radiographs. Proc CAR-Computer Assisted Radiology. 1996: 380-383.
6. Yoshida H, Nishikawa RM, Giger ML, Doi K. Optimally weighted wavelet packet transform for detection of clustered microcalcifications in digital mammograms. Digital Mammography. 1996; 96: 317-322.
7. Yoshida H, Doi K, Nishikawa RM, Giger ML. Signal/background separation by wavelet packets for detection of microcalcifications in mammograms. Proc SPIE. 1996; 2825: 805-811. doi: 10.1117/12.255304
8. Yoshida H, Katsuragawa S, Amit Y, Doi K. Wavelet snake for classification of nodules and false positives in digital chest radiographs. Proc IEEE Engineering in Medicine and Biology (EMBS97). 1997; 509-512. doi: 10.1109/IEMBS.1997.757657
9. Yoshida H, Katsuragawa S. Amit Y, Doi K. Wavelet based deformable contour and its application to detection of pulmonary nodules on chest radiographs. Proc SPIE. 1997; 3169: 328-337.
10. Yoshida H, Keserci B, Doi K. Computer aided diagnosis of pulmonary nodules in chest radiographs: a wavelet based snake approach. Proc Eleventh IEEE Symposium on Computer Based Medical Systems (CBMS98). 1998: 258-263.
11. Yoshida H. Removal of normal anatomic structures in radiographs using wavelet based non-linear variational method for image matching. Proc SPIE. 1998; 3458: 174-181.
12. Yoshida H, Keserci B, Doi K. Computer aided diagnosis of pulmonary nodules in chest radiographs: distinction of nodules from false positives based on wavelet snake and artificial neural network. Computer Aided Diagnosis in Medical Imaging: Proc First International Workshop on Computer-Aided Diagnosis. Elsevier International Congress Series. 1999; 1182: 45-50.
13. Yoshida H, Anastasio A, Nagel R, Nishikawa R, Doi K. Computer aided diagnosis for detection of clustered microcalcifications in mammograms: automated optimization of performance based on genetic algorithm. Computer Aided Diagnosis in Medical Imaging: Proc First International Workshop on Computer-Aided Diagnosis. Elsevier International Congress Series. 1999: 247-252.
14. Yoshida H, Keserci B, Casalino D, Coskun A, Ozturk O, Savranlar A. Segmentation of liver tumors in ultrasound images based on scale space analysis of the continuous wavelet transform. Proc IEEE International Ultrasonics Symposium. 1999: 100-104.
15. Yoshida H. Simultaneous registration and segmentation of images in wavelet domain. Proc SPIE. 1999; 3813: 591-597.
16. Yoshida H. Multiresolution non-rigid image registration method and its application to removal of normal anatomic structures in chest radiographs. Proc IEEE International Conference on Image Processing (ICIP99). 1999; 3: 440-445.
17. Yoshida H, Doi K. Computerized detection of pulmonary nodules in chest radiographs: reduction of false positives based on bilateral symmetry of lungs. Proc SPIE. 2000; 3979: 97-102.
18. Yoshida H, Doi K. Classification of liver lesions in ultrasonic images. Proc SPIE. 2000; 3982: 252-256.
19. Yoshida H, Doi K, MacMahon H. Computerized detection of pulmonary nodules in chest radiographs: reduction of false positives based on radiologists visual analysis strategy. Proc CARS-Computer Assisted Radiology and Surgery. 2000: 809-813.
20. Yoshida H. Local contralateral subtraction based on simultaneous segmentation and registration method for computerized detection of pulmonary nodules. Proc SPIE. 2001; 4322: 426-430.
21. Yoshida H, Masutani Y, MacEneaney P, Dachman AH. Computer aided detection of polyps in CT colonography based on geometric features. Proc SPIE. 2001; 4321: 53-57.
22. Näppi J, MacEneaney P, Dachman AH, Yoshida H. Computer aided detection of polyps in CT colonography: evaluation of volumetric features in differentiating polyps from false positives. Proc CARS-Computer Assisted Radiology and Surgery. 2001; 635-640.
23. Yoshida H, Näppi J, Frimmel H, Dachman AH. Computer aided diagnosis in CT colonography: detection of polyps based on geometric and texture features. Proc SPIE. 2002; 4684: 1235-1245.
24. Näppi J, MacEneaney P, Dachman AH, Yoshida H. Effect of knowledge guided colon segmentation in automated detection of polyps in CT colonography. Proc SPIE. 2002; 4683: 222-229. doi: 10.1117/12.463586
25. Näppi J, Yoshida H. Computer aided detection of polyps in CT colonography: effect of feature guided polyp segmentation. Proc CARS-Computer Assisted Radiology and Surgery. 2002: 749-755.
26. Yoshida H. New technologies in 3D CAD for virtual colonoscopy. Proc International Conference on Diagnostic Imaging and Analysis. 2002: 29-34.
27. Dachman AH, Yoshida H. Virtual colonoscopy: past, present, and future. The Radiologic Clinics of North America. 2003; 41: 377-393.
28. Frimmel H, Näppi J, Yoshida H. Fast and robust method to compute colon centerline in CT colonography. Proc SPIE. 2003; 5031: 381-387.
29. Näppi J, Frimmel H, Yoshida H. Computer aided detection of polyps and masses for CT colonography. Proc SPIE. 2003; 5032: 860-868.
30. Näppi J, Frimmel H, Dachman AH, Yoshida H. A new high-performance CAD scheme for the detection of polyps in CT colonography. Proc SPIE. 2004; 5370: 839-348. doi: 10.1117/12.536127
31. Dachman AH, Yoshida H. CAD for CT colonography: importance and controversies. Proc CARS-Computer Assisted Radiology and Surgery. 2004; 1268: 973-977. doi: 10.1016/j.ics.2004.03.363
32. Yoshida H, Dachman AH. CAD for CT colonography: current status and future. Proc CARS-Computer Assisted Radiology and Surgery. 2004; 1268: 973-977.
33. Näppi J, Frimmel H, Okamura A, Dachman AH, Miller FH, Dalal KA, Yoshida H. Region-based supine-prone correspondence for reduction of false positives in CAD of CT colonography. Proc CARS-Computer Assisted Radiology and Surgery. 2004; 1268: 993-998. doi: 10.1016/j.ics.2004.03.248
34. Okamura A, Dachman AH, Parsad N, Näppi J, Yoshida H. Evaluation of the Effect of CAD on observers performance in detection of polyps in CT colonography. Proc CARS-Computer Assisted Radiology and Surgery. 2004; 1268: 989-992. doi: 10.1016/j.ics.2004.03.174
35. Näppi J, Yoshida H. Ranking of polyp candidates for CAD in CT colonography. Proc SPIE. 2005; 5746: 432-439. doi: 10.1117/12.596432
36. Cai W, Dachille F, Harris GJ, Yoshida H. Vesselness propagation-a fast interactive vessel structure segmentation method. Proc SPIE. 2006; 6144: 614447-1-8.
37. Cai W, Näppi J, Zalis ME, Harris GJ, Yoshida H. Digital bowel cleansing for computer-aided detection of polyps in fecal-tagging CT colonography. Proc SPIE. 2006; 6144: 614422-1-9.
38. Näppi J, Frimmel H, Yoshida H. Centerline-based colon segmentation for CAD of CT colonography. Proc SPIE. 2006; 6144: 61445H-1-8.
39. Cai W, Yoshida H, Harris GJ. Dynamic-thresholding level set: a novel computer-aided volumetry method for liver tumors in hepatic CT images. Proc SPIE. 2007; 65142W-1-8.
40. Näppi J, Yoshida H, Zalis M, Cai W, Lefere P. Pseudo-enhancement correction for computer-aided detection in fecal-tagging CT colonography. Proc SPIE. 2007; 6514: 65140A-1 -1-8.
41. Nagata K, Näppi J, Cai W, Yoshida H. Minimum-invasive early diagnosis of colorectal cancer with CT colonography: techniques and clinical value. Expert Opin Med Diagn. 2008; 2: 1233-1246. doi: 10.1517/17530059.2.11.1233
42. Cai W, Zalis M, Yoshida H. Mosaic decomposition method for detection and removal of inhomogeneously tagged regions in electronic cleansing for CT colonography. Proc SPIE. 2008; 6915: 69150D-1-8.
43. Cai W, Zalis ME, Yoshida H. Reduction of electronic-cleansing artifacts in cathartic and non-cathartic fecal-tagging CT colonography. Proc MICCAI 2008 Workshop on Computational and Visualization Challenges in the New Era of Virtual Colonoscopy. 2008: 70-77.
44. Näppi J, Yoshida H. Automated scheme for preparation-independent detection of colorectal lesions in CT colonography. Proc MICCAI 2008 Workshop on Computational and Visualization Challenges in the New Era of Virtual Colonoscopy. 2008: 127-135.
45. Seghouane A-K, Näppi J, Yoshida H. Feature selection with BIC and PCA for polyp detection in CT colonography. Proc MICCAI 2008 Workshop on Computational and Visualization Challenges in the New Era of Virtual Colonoscopy. 2008: 64-69.
46. Yoshida H, Näppi J. CAD in CT colonography: past, present, and future. Proc MICCAI 2008 Workshop on Computational and Visualization Challenges in the New Era of Virtual Colonoscopy. 2008: 19-21.
47. Cai W, Yoshida H, Zalis M. Electronic fecal tagging: reduction of inhomogeneous tagging for detection of polyps in non-cathartic CT colonography. Proc SPIE. 2009; 6915: 69150D-1-8.
48. Näppi J, Cai W, Yoshida H. Computer-aided detection of colorectal lesions for cathartic-free CT colonography. Proc Sixth IEEE International Symposium on Biomedical Imaging (ISBI09). 2009: 911-914.
49. Yoshida H, Näppi J, Cai W. Computer-aided detection of polyps in CT colonography: performance evaluation in comparison with human readers based on large multicenter clinical trial cases. Proc Sixth IEEE International Symposium on Biomedical Imaging (ISBI09). 2009: 919-922.
50. Singh AK, Yoshida H, Sahani DV. Advanced postprocessing and the emerging role of computer-aided detection. Radiologic Clinics of North America. 2009; 47: 59-77. doi: 10.1016/j.rcl.2008.11.004
51. Cai W, Liu, B, Yoshida H. Dual-energy electronic cleansing for non-cathartic CT Colonography: a phantom study. Proc SPIE. 2010; 7624: 76240C-1-8.
52. Sainani NI, Näppi J, Sahani DV, Yoshida H. Computer-aided detection of small bowel strictures in CT enterography. Proc SPIE. 2011; 7963: 79632J-1-6.
53. Näppi J, Regge D, Yoshida H. Probabilistic method for context-sensitive detection of polyps in CT colonography. Proc SPIE. 2011; 7963: 79631D-1-6.
54. Cai W, Yoshida H. Electronic cleansing in CT colonography: past, present, and future. Virtual Colonoscopy and Abdominal Imaging 2010, Lecture Notes in Computer Science. 2011; 6668: 1-8. doi: 10.1007/978-3-642-25719-3_1
55. Näppi J, Lee J-G, Fletcher JG, Yoshida H. Computer-assisted diagnosis for quantitative image-based analysis of Crohns disease in CT enterography. Virtual Colonoscopy and Abdominal Imaging 2010, Lecture Notes in Computer Science. 2011; 6668: 84-90.
56. Lee J-G, Cai W, Singh A, Yoshida H. Estimation of necrosis volumes in focal liver lesions based on multi-phase hepatic CT images. Virtual Colonoscopy and Abdominal Imaging 2010, Lecture Notes in Computer Science. 2011; 6668: 60-67.
57. Sainani N, Näppi J, Sahani DV, Yoshida H. Computer-aided detection of small bowel strictures for emergency radiology in CT enterography. Virtual Colonoscopy and Abdominal Imaging 2010, Lecture Notes in Computer Science. 2011; 6668: 91-97. doi: 10.1007/978-3-642-25719-3_13
58. Cai W, Lee J-G, Kim S-H, Yoshida H. Dual-energy electronic cleansing for artifact-free visualization of the colon in fecal-tagging CT colonography. Abdominal Imaging 2011, Lecture Notes in Computer Science. 2012; 7029: 8-17. doi: 10.1007/978-3-642-28557-8_2
59. Näppi J, Regge D, Yoshida H. Comparative performance of random forest and support vector machine classifiers for detection of colorectal lesions in CT colonography. Abdominal Imaging 2011, Lecture Notes in Computer Science. 2012; 7029: 27-34. doi: 10.1007/978-3-642-28557-8_4
60. Näppi J, Regge D, Yoshida H. Ensemble detection of colorectal lesions for CT colonography. Abdominal Imaging 2011, Lecture Notes in Computer Science. 2012; 7029: 60-67. doi: 10.1007/978-3-642-28557-8_8
61. Näppi J, Gryspeerdt S, Lefere P, Zalis M, Yoshida H. Automated detection of colorectal lesions in non-cathartic CT colonography. Abdominal Imaging 2011, Lecture Notes in Computer Science. 2012; 7029: 68-75.
62. Näppi J, Sahani DV, Fletcher JG, Yoshida H. Automated detection and diagnosis of Crohns disease in CT enterography. Abdominal Imaging 2011, Lecture Notes in Computer Science. 2012; 7029: 84-90.
63. Näppi J, Kim S-H, Yoshida H. Automated detection of colorectal lesions with dual-energy CT colonography. Proc SPIE. 2012; 7963: 79632J-1-6.
64. Cai W, Kim S-H, Lee J-G, Yoshida H. Virtual colon tagging for electronic cleansing in dual-energy fecal-tagging CT colonography. Proc IEEE Eng Med Biol Soc. 2012; 2012: 3736-3739.
65. Näppi J, Kim S-H, Yoshida H. Volumetric detection of colorectal lesions for noncathartic dual-energy computed tomographic colonography. Proc IEEE Eng Med Biol Soc. 2012; 2012: 3740-3743.
66. Yoshida H, Wu, Y, Cai W. Scalable, high-performance 3D image computing platform: system architecture and application to virtual colonoscopy. Proc IEEE Eng Med Biol Soc. 2012; 2012: 3994-3997.
67. Näppi J, Kim S-H, Yoshida H. Adaptive volumetric detection of lesions for minimal-preparation dual-energy CT colonography. Abdominal Imaging 2012, Lecture Notes in Computer Science. 2012; 7601: 30-39.
68. Näppi J, Imuta M, Yamashita Y, Yoshida H. Computer-aided detection for ultra-low-dose CT colonography. Abdominal Imaging 2012, Lecture Notes in Computer Science. 2012; 7601: 40-48.
69. Näppi J, Rockey D, Regge D, Yoshida H. Application of CT acquisition parameters as features in computer-aided detection for CT colonography. Abdominal Imaging 2012, Lecture Notes in Computer Science. 2012; 7601: 69-77. doi:10.1007/978-3-642-33612-6_8
70. Lee S-H, Näppi J, Yoshida H. Comparative performance of state-of-the-art classifiers in computer-aided detection for CT colonography. Abdominal Imaging 2012, Lecture Notes in Computer Science. 2012; 7601: 78-87. doi: 10.1007/978-3-642-33612-6_9
71. Cai W, Lee J-G, Zhang D, Piel C, Yoshida H. Piecewise structural diffusion defined on shape index for noise reduction in dual-energy CT images. Abdominal Imaging 2012, Lecture Notes in Computer Science. 2012; 7601: 88-96.
72. Lee S-H, Cai W, Yoshida H. Tracer kinetic modeling by Morales-Smith hypothesis in hepatic perfusion CT. Abdominal Imaging 2012, Lecture Notes in Computer Science. 2012; 7601: 292-302. doi: 10.1007/978-3-642-33612-6_31
73. Näppi J, Kim S-H, Yoshida H. Volumetric detection of flat lesions for minimal-preparation dual-energy CT colonography. Proc SPIE. 2013; 8670: 86702E-1-6.
74. Cai W, Zhang D, Lee J-G, Yoshida H. Low-dose dual-energy electronic cleansing for fecal-tagging CT colonography. Proc SPIE. 2013; 8670: 86700W-1-9. doi: 10.1117/12.2008127
75. Näppi JJ, Do S, Yoshida H. Computer-aided detection of colorectal lesions with super-resolution CT colonography: Pilot evaluation. Abdominal Imaging 2013, Lecture Notes in Computer Science. 2013; 8198: 73-80. doi: 10.1007/978-3-642-41083-3_9
76. Do S, JJ. Näppi, Yoshida H, Iterative reconstruction for ultra-low-dose laxative-free CT Colonography. Abdominal Imaging 2013, Lecture Notes in Computer Science. 2013; 8198: 99-106.
77. Ryu Y, Näppi JJ, Phan M, Yoshida H. Computer-aided detection of non-polypoid flat lesions in CT colonography: Observer performance study. Abdominal Imaging 2013, Lecture Notes in Computer Science. 2013; 8198: 81-88. doi: 10.1007/978-3-642-41083-3_10
78. Lee SH, Ryu Y, Hayano K, Yoshida H. Continuous-time flow-limited modeling by convolution area property and differentiation product rule in 4-phase liver dynamic contrast-enhanced CT. Abdominal Imaging 2013, Lecture Notes in Computer Science. 2013; 8198; 259-269. doi: 10.1007/978-3-642-41083-3_29
79. Lee SH, Hayano K, Sahani D, Yoshida H. Use of tracer kinetic model-driven biomarkers for monitoring antiangiogenic therapy of hepatocellular carcinoma in first-pass perfusion CT. Abdominal Imaging 2013, Lecture Notes in Computer Science. 2013; 8198: 270-279. doi: 10.1007/978-3-642-41083-3_30
80. Yoshida H, Wu Y, Cai W. Analysis of scalability of high-performance 3D image processing platform for virtual colonoscopy. Proc Soc Photo Opt Instrum Eng. 2014; 9039: 90390U. doi: 10.1117/12.2043869
81. Näppi J, Ryu Y, Yoshida H. Progressive region-based colon extraction for computer-aided detection and quantitative imaging in cathartic and non-cathartic CT colonography. Proc Soc Photo Opt Instrum Eng. 2014; 9035: 90352X. doi: 10.1117/12.2043890
82. Lee SH, Hayano K, Sahani D, Zhu A, Yoshida H. Parameter comparison between fast-water-exchange-limit-constrained standard and water-exchange-modified dual-input tracer kinetic models for DCE-MRI in advanced hepatocellular carcinoma. ABDI 2014, Lecture Notes in Computer Science. 2014; 8676: 33-47. doi: 10.1007/978-3-319-13692-9_4
83. Lee SH, Hayano K, Sahani D, Zhu A, Yoshida H. Kinetic Textural Biomarker for Predicting Survival of Patients with Advanced Hepatocellular Carcinoma after Antiangiogentic Therapy by Use of Baseline First-Pass Perfusion CT. ABDI 2014, Lecture Notes in Computer Science. 2014; 8676: 48-61. doi: 10.1007/978-3-319-13692-9_5
84. Lee SH, Yasuji Ryu, Hayano K, Yoshida H. Feasibility of single-input tracer kinetic modeling with continuous-time formalism in liver 4-phase dynamic contrast-enhanced CT. ABDI. 2014, Lecture Notes in Computer Science. 2014; 8676: 62-73. doi: 10.1007/978-3-319-13692-9_6
85. Näppi J, Tachibana R, Regge D, Yoshida H. Information-preserving pseudo-enhancement correction for non-cathartic low-dose dual-energy CT colonography. Abdominal Imaging. 2014, Lecture Notes in Computer Science. 2014; 8676: 159-168.
86. Tachibana R, Näppi J, Yoshida H. Application of pseudo-enhancement correction to virtual monochromatic CT colonography. ABDI 2014, Lecture Notes in Computer Science. 2014; 8676: 169-178.
87. Näppi J, Regge D, Yoshida H. Context-specific method for detection of soft-tissue lesions in non-cathartic low-dose dual-energy CT colonography. Proc Soc Photo Opt Instrum Eng. 2015; 9414: 94142Y.
88. Tachibana R, Näppi J, Kim SH, Yoshida H. Electronic cleansing for dual-energy CT colonography based on material decomposition and virtual monochromatic imaging. Proc Soc Photo Opt Instrum Eng. 2015; 9414: 94140Q. doi: 10.1117/12.2082375
89. Nasirudin RA, Tachibana R, Näppi JJ, et al. A comparison of material decomposition techniques for dual-energy CT colonography. Proc Soc Photo Opt Instrum Eng. 2015; 9412: 94122E-1-6. doi: 10.1117/12.2081982


REVIEWS, CHAPTERS, MONOGRAPHS AND EDITORIALS


1. Yoshida H. Explicit derivation of Gauss Bonnet combination from string theories. University of Tokyo, Elementary Particle Physics Laboratory (EPPL) Technical Report. 1986: UT 481.
2. Liang JZ, Higgins WE, Summers RM, Yoshida H. Introduction to the special section on virtual endoscopy. Editorial. IEEE Transactions on Medical Imaging. 2004; 23: 1333-1334.
3. Yoshida H, Svoboda AC, and Orton CG. Within the next five years CT colonography will make conventional colonoscopy obsolete for colon cancer screening. Point/Counterpoint. Medical Physics. 2006; 33: 2679-2682.
4. Yoshida H. Wavelet transform. In: Uchida S, Odera Y, Fujita H, editors, Digital Diagnostic Radiology. Ohmu-Sya. 1998; 19-30.
5. Yoshida H, Katsuragawa S, Amit Y, Doi K. Wavelet-based deformable contour and its application to detection of pulmonary nodules on chest radiographs. In: Ritter GX, ed. Selected SPIE Papers on CD-ROM. Mathematical Imaging and Vision. The International Society for Optical Engineering. 1999; 8.
6. Yoshida H. Neural network for classification of focal liver lesions in ultrasound images. In: Jain LC De Wilde P, eds. Practical Applications of Soft Computing Techniques. Kluwer Academic Publishers. 2001; 355-378.
7. Yoshida H. Wavelets for computer-aided diagnosis in medical imaging. In: Petrosian AA, Meyer FG, eds. Wavelets in Signal and Image Analysis. Kluwer Academic Publishers; 2001; 418-452.
8. Summers RM, Yoshida H. Future directions of CT colonography: computer-aided diagnosis. In Dachman AH editor. Atlas of Virtual Colonoscopy. Springer; 2003; 55-62.
9. Dachman AH, Glick S, Yoshida H. Colon cancer screening: the potential role of virtual colonoscopy. In: DeVita VT, Hellman S, Rosenberg SA, eds. Progress in Oncology. Jones and Bartlett, Massachusetts. 2003; 298-313.
10. Summers RM, Yoshida H. Future directions: computer-aided diagnosis. In: Dachman AH, ed. Fundamentals of Virtual Colonoscopy. Springer; 2005; 79-89.
11. Dachman AH, Yoshida H. Virtual endoscopic imaging. In: Weinstein W, Hawkey CJ, Bosch J, eds. Gastroenterology and hepatology: the modern clinicians guide. Elsevier Science, London, UK; 2005. 129: 955-962.
12. Yoshida H. Chapter 11: The future: computer-aided detection. In: Lefere P, Gryspeerdt S, eds. Virtual colonoscopy: a practical guide. Springer. 2005; 137-151.
13. Yoshida H. Computer-aided diagnosis for virtual colonoscopy. In: Zharkova V, Jain L, eds. Artificial intelligence in recognition and classification of astrophysical and medical images. Springer. 2007; 302-338.
14. Yoshida H, Dachman AH. Computer Aided Diagnosis: Clinical Applications in CT Colonography. In: Neri E, Caramella D, Bartolozzi C, editors. Image Processing in Radiology: Current Applications. Springer. 2007; 375-392.
15. Singh AK, Harris GJ, Cai W, Sahani D.V, Yoshida H. Chapter 24: Principles of 3D post-processing, Abdominal Imaging. In: Sahani D, Samir A, eds. Elsevier: Saunders. 2010; 159-170.
16. Singh AK, Harris GJ, Sahani DV, Cai W, Yoshida H. Chapter 25: Advanced applications of post-processing, Abdominal Imaging. In: Sahani D, Samir A, eds. Elsevier: Saunders; 2010; 171-182.
17. Singh AK, Harris GJ, Yoshida H, Sahani DV. Chapter 60: CT of the liver, Abdominal Imaging. In: Sahani D, Samir A, eds. Elsevier: Saunders; 2010; 517-528.
18. Yoshida H, Cadi M. CAD, Coloscopie virtuelle. In: Cadi M, ed. Lavoisier. 2010; 106-128.
19. Yoshida H. Chapter 14: The future: computer-aided detection. In: Lefere P, Gryspeerdt S, eds. Virtual colonoscopy: a practical guide (2nd revised edition). Springer; 2010; 175-189.


BOOKS/TEXTBOOKS FOR THE MEDICAL OR SCIENTIFIC COMMUNITY


1. Yoshida H, Takahara T. Windows magic, Koei Publishing Company; 1992.
2. Yoshida H, Takahara T. authors. The best guide to NeXT computers. Koei Publishing Company; 1992.
3. Yoshida H, editor. Introduction to the BASIC programming language. Fuji Software Inc.; 1992.
4. Yoshida H, editor. Essential LAN terminology 100. Koei Publishing Company; 1993.
5. Yoshida H, editor. The best guide to the World Wide Web. Koei Publishing Company; 1996.
6. Yoshida H, editor. Essential network terminology 100. Koei Publishing Company; 1997.
7. Yoshida H, editor. The internet dictionary, Koei Publishing Company; 1997.
8. Yoshida H, Jain A Ichalkaranje A, Jain LC. Advanced Computational Intelligence Paradigms in Healthcare . Springer; 2007.
9. Vaidya S, Jain LC, Yoshida H. Advanced Computational Intelligence Paradigms in Healthcare. Springer; 2007.
10. Toriwaki J, Yoshida H. Fundamentals of Three-dimensional Digital Image Processing. Springer; 2009.
11. Yoshida H, Cai W. Virtual Colonoscopy and Abdominal Imaging: Computational Challenges and Clinical Opportunities (Second International Workshop, Held in Conjunction with MICCAI 2010, Beijing, China, September 2010, Revised Selected Papers), Lecture Notes in Computer Science. Springer. 2011; 6668: 141.
12. Yoshida H, Sakas G, Linguraru M. Abdominal Imaging: Computational and Clinical Applications (Third International Workshop, Held in Conjunction with MICCAI 2011, Toronto, Canada, September 2011, Revised Selected Papers), Lecture Notes in Computer Science. Springer. 2012; 7029: 274.
13. Yoshida H, Hawkes D, Vannier, M. Abdominal Imaging: Computational and Clinical Applications (Fourth International Workshop, Held in Conjunction with MICCAI 2012, Nice, France, October 2012, Proceedings), Lecture Notes in Computer Science. 2012; 7601: 318.
14. Yoshida H, Warfield S, Vannier M. Abdominal Imaging: Computational and Clinical Applications (5th International Workshop, Held in Conjunction with MICCAI 2013, Nagoya, Japan, September, 2013, Proceedings), Lecture Notes in Computer Science. 2013; 8198: 300.
15. Yoshida H, Näppi JJ, Saini S. Abdominal Imaging: Computational and Clinical Applications (6th International Workshop, ABDI 2014, Held in Conjunction with MICCAI 2014, Cambridge, MA, USA, September 14, 2014), Lecture Notes in Computer Science. 8676: 296.


LETTERS TO THE EDITOR


1. Evancho AM, Yoshida H, Dachman A. Computer aided diagnosis: blessing or curse? Radiology. 2002; 225: 606-607.
2. Cai W, Lee JG, Yoshida H, Kim SH. Respond to Dual-energy CT for diagnostic CT colonography. Radiographics. 2014; 34: 848.

Jessie Qiaoyi Liang, PhD

Research Assistant Professor
Department of Medicine and Therapeutics
Faculty of Medicine
Shenzhen Research Institute
The Chinese University of Hong Kong
Rm 707, Lika Sheng Medical Sciences Building
Prince of Wales Hospital, Hong Kong

BiographyResearch InterestScientific ActivitiesPublications

Dr. Liang has been involved in the identification and characterization of cancer-related genes since 2004. Whilst completing her PhD in Oncology at the Cancer Institute of Zhejiang University, she identified and designated three novel cancer-related genes, including HERV-HX, HERV-H4p15, and psiTPTE22-HERV. Upon completion of her doctorate, Dr. Liang devoted one year to establishing rapid prenatal diagnosis methods, one of which has been granted with patent number ZL 2010 1 0019380.5. Dr. Liang’s research now focuses on cancer genomics, metagenomics, human endogenous retroviruses in cancers, and functional studies on cancer-related genes. Her work has resulted in publication of 20 peer-reviewed research articles, of which 12 are as first or corresponding author. She is now principal investigator for two projects supported by the National Natural Science Foundation of China, three projects supported by municipal funding, and co-investigator to 5 other projects.

Her research interests include: Gastrointestinal cancers, Biomarkers, Human endogenous retrovirus.

Research Awards

• 2014, AACR Travel Prize, AACR
• 2013, Poster of Distinction, Digestive Disease Week 2013, Orlando, US
• 2013, Annual Research Excellence Award, Shenzhen Municipal Science and Technology Innovation Council
• 2012/13, Research Fellowship Scheme, The Chinese University of Hong Kong
• 2012, Annual Research Excellence Award, Shenzhen Municipal Science and Technology Innovation Council
• 2011/12, Research Fellowship Scheme, The Chinese University of Hong Kong


Professional Society Membership

• 2014 Nov-present Member, American Association for Cancer Research (AACR)
• 2012 April-prenent Member, The Chinese Cancer Genome Consortium (CCGC)

Selected Publications

1. Liang Q, Yao X, Tang S, et al. Integrative Identification of Epstein-Barr Virus-associated Mutations and Epigenetic Alterations in Gastric Cancer. Gastroenterology. 2014; 147(6): 1350-1362.e4. doi: 10.1053/j.gastro.2014.08.036
2. Xie X, Liang Q. Establishment of a 10-plex Quantitative Fluorescent-PCR Assay for Rapid Diagnosis of Sex Chromosome Aneuploidies. PLoS One. 2014; 9(9): e106307. doi: 10.1371/journal.pone.0106307
3. Yu J, Wu WK, Li X, et al. Novel Recurrently Mutated Genes and a Prognostic Mutation Signature in Colorectal Cancer. Gut. 2014; gutjnl-2013-306620. doi: 10.1136/gutjnl-2013-306620
4. Yu C, Yu J, Yao X, et al. Discovery of biclonal origin and a novel oncogene SLC12A5 in colon cancer by single-cell sequencing. Cell research.2014; 24(6): 701-712. doi: 10.1038/cr.2014.43
5. Zhang N, Chu ES, Zhang J, et al. Peroxisome Proliferator Activated Receptor Alpha Inhibits Hepatocarcinogenesis through Mediating NF-κB Signaling Pathway. Oncotarget.2014; 5(18): 8330-8340.
6. Yu J, Liang Q, Wang J, et al. Zinc-Finger Protein 331, a novel putative tumor suppressor, suppresses growth and invasiveness of gastric cancer. Oncogene. 2013; 32(3): 307-317. doi: 10.1038/onc.2012.54
7. Zhao J, Liang Q, Cheung KF, et al. Genome-wide identification of Epstein-Barr virus-driven promoter methylation profiles of human genes in gastric cancer cells. Cancer. 2013; 119(2): 304-312. doi: 10.1002/cncr.27724
8. Liang Q, Xu Z, Xu R, Wu L, Zheng S. Expression patterns of non-coding spliced transcripts from human endogenous retrovirus HERV-H elements in colon cancer. PLoS One. 2012; 7(1): e29950. doi: 10.1371/journal.pone.0029950
9. Liang Q, Ding J, Xu R, Xu Z, Zheng S. The novel human endogenous retrovirus-related gene, psiTPTE22-HERV, is silenced by DNA methylation in cancers. Int J Cancer. 2010; 127(8): 1833-1843. doi: 10.1002/ijc.25213.
10. Liang Q, Ding J, Xu R, Xu Z, Zheng S. Identification of a novel human endogenous retrovirus and promoter activity of its 5 U3. Biochem Biophys Res Commun. 2009; 382(2): 470-474. doi: 10.1016/j.bbrc.2009.03.058

Meir Mizrahi, MD

Division of Gastroenterology
Center for Advanced Endoscopy
Beth Israel Deaconess Medical Center and Harvard Medical School
330 Brookline Ave, Boston, MA 02215, USA

BiographyResearch InterestScientific ActivitiesPublications
Education

• 09/1998 - 07/2004: Bologna, Medicine (81697)
• 06/2005 - 05/2006: Internship, Hadassah Medical Center (Jerusalem, Israel)
• 09/2006 - 08/2010: Residancy training, Internal Medicine A, Hadassah Medical Center (Jerusalem, Israel)
• 01/2011 - 01/2013: Fellowship training, Gastroenterology, Hadassah Medical Center (Jerusalem Israel)
• 02/2013 - 03/15: Senior physician, Gastroenterology, Hadassah Medical Center (Jerusalem Israel)
• 03/2015- present: Advanced Endoscopy Research Fellowship, Advanced Endoscopy unit, Beth Israel Deaconess Medical Center


Appointments at the Hebrew University

• 01/2009 - 07/2013: Academic Instructor, Hebrew University - Hadassah Medical School
• 07/2013 - Present: Lecturer in Internal Medicine- Hebrew University-Hadassah School of Medicine

His research interests include: Liver diseases and immunology, Hepitocellular Carcinoma, Liver surgery, Cirrhosis

Professional Membership

• 01/2008 - ongoing: Member Israeli association for the study of liver
• 01/2009 - ongoing: Member Israeli gastroenterology association
• 01/2010 - ongoing : Member of the American association for the study of liver disease
• 01/2012 - ongoing: Member of the American gastroenterology association (AGA)
• 05/2013 - ongoing: Member of the American society of gastrointestinal endoscopy (ASGE)


Awards & Recognitions

• 08/2004: Graduated medical school with honor
• 04/2009: European Association for the Study of the Liver (EASL) - Copenhagen 2009 convention - Young investigator research award
• 04/2010: European Association for the Study of the Liver (EASL) - Vienna 2010 convention - Young investigator research award
• 11/2011: Hebrew University, School of Medicine, Faculty prize for "Distinction in Clinical Work" 2011
• 01/2012: Israeli Gastroenterology association - Best work presentation

Original Papers in Peer Reviewed Journals

1. Mizrahi M, Lalazar G, Ben Yaacov A, et al. Beta-glycoglycosphingo lipid-induced augmentation of the anti-HBV immune response is associated with altered CD8 and NKT lymphocyte distribution: a novel adjuvant for HBV vaccination. Vaccine. 2008; 26(21): 2589-2595. doi: 10.1016/j.vaccine.2008.03.026
2. Mizrahi M, Lalazar G, Adar T, Raz I, Ilan Y. Assessment of insulin resistance by a 13C glucose breath test: a new tool for early diagnosis and follow-up of high-risk patients. Nutr J. 2010; 27(9): 25. doi: 10.1186/1475-2891-9-25.
3. Mizrahi M, Roemi L, Shouval D, et al. Bacteremia and Endotipsitis Following Trans-Jugular Intrahepatic Portosystemic Shunting (TIPS): A multivariate Analysis of Risk Factors. World J Hepatol. 2011; 3(5): 130-136. doi: 10.4254/wjh.v3.i5.130
4. Adar T, Ben Yaacov A, Lalazar G, et al. Oral administration of IgG-enhanced colostrum alleviates insulin resistance and liver injury and is associated with alterations NKT cells. Clinical and Experimental Immunology. 2012; 167(2): 252-260. doi: 10.1111/j.1365-2249.2011.04511.x.


Case Reports

5. Mizrahi M, Lalalzar G, Horwich Y, Adar T, Safadi R. Benign recurrent intrahepatic cholestasis type II- a rare cause of direct hyperbilirubinemia exacerbation with hepatic fibrosis. Harefua. 2008; 147(5): 381-383.
6. Adar T, Rubinger D, Lalalzar G, Levi L, Mizrahi M, Bogot RN. Nephrogenic systemic fibrosis. Harefua. 2008; 147(10): 801-803, 837.
7. Samuel N, Lalazar G, Shuvy M, et al. Successful use of streptokinase for the treatment of empyema thoracis during advanced pregnancy: A case report. Respiratory Medicine CME. 2009; 2(1): 21-24. doi: 10.1016/j.rmedc.2008.10.004
8. Adar T, Mizrahi M, Pappo O, Scheiman-Elazary A, Shibolet O. Adalimumab-induced autoimmune hepatitis. J Clin Gastroenterol. 2010; 44(1): e20-e22. doi: 10.1097/MCG.0b013e3181a745e7.
9. Mizrahi M, Adar T, Ilan Y. Idiopathic right sided endocarditis an uncommon manifestation of pulmonary cavitations. Harefua. 2009; 148(4): 233-234, 277.
10. Mizrahi M, Ben- Chetrit E. Relapsing macrophage activating syndrome in a young patient with Stills disease. J Med Case Reports. 2009; 13: 138. doi: 10.1186/1752-1947-3-138
11. Mizrahi M, Adar T, Orenbuch-Harroch E, Elitzur Y. Non-ST Elevation Myocardial Infraction after High Dose Intravenous Immunoglobulin Infusion. Case Report Med. 2009; 2009: 861370. doi: 10.1155/2009/861370
12. Mizrahi M. The hypercoagulability of intravenous immunoglobulin. Clinical Advances in Hematology & Oncology. 2011; 9(1): 49-50.
13. Mizrahi M, Almogy G, Adar T, Lysy J. Dumping syndrome following Nissen fundoplication in an adult patient diagnosed By BreathID® continuous online 13C-octanoide acid breath test a case report. BMC Gastroenterol. 2011; 11: 98. doi: 10.1186/1471-230X-11-98
14. Adar T, Mizrahi M. Dapsone induced eosinophilic pneumonia. Eur Ann Allergy Clin Immunol. 2012; 44(3): 144-146.
15. Adar T, Mizrahi M. Inguinal hernia - A possible pitfall in diagnosing ascites. Liver International. 2013; 33(9): 1449. doi: 10.1111/liv.12180.


Reviews

16. Mizrahi M, Adar T, Shouval D, Bloom AI, Shibolet O. Endotipsitis-persistent infection of transjugular intrahepatic portosystemic shunt: pathogenesis, clinical features and management. Liver Int. 2010; 30(2): 175-183. doi: 10.1111/j.1478-3231.2009.02158.x
17. Mizrahi M, Ilan Y. The gut mucosa as a site for induction of regulatory T cells. Curr Pharm Des. 2009; 15(11): 1191-1202. doi: 10.2174/138161209787846784
18. Mizrahi M, Ben Yaacov A, Ilan Y. Gastric stimulation for losing weight loss. World J Gasroentrol. 2012; 18(19): 2309-2319. doi: 10.3748/wjg.v18.i19.2309


Editorial

1.. Benson AA, Mizrahi M. Endoscopy: from diagnosis to therapeutics. Gastro Open J. 2015; 1(2): e1-e3.
2. Khoury T, Rmeileh AA, Cohen J, Mizrahi M. A double-edged sword and swinging pendulum: the evolving role of percutaneous endoscopic gastrostomy tubes in patients with advanced dementia. Gastro Open J. 2015; 1(4): e4-e6. doi: 10.17140/GOJ-1-e002

Jacintha O. Sullivan, PhD

Associate Professor
Department of Surgery
Institute of Molecular Medicine
Trinity Centre for Health Sciences
St James Hospital
Dublin 8, Ireland

BiographyResearch InterestScientific ActivitiesPublications

Dr. O Sullivan was appointed as Associate Professor in the Department of Surgery, St. Jamess Hospital / TCD in 2010. Jacintha graduated from University College Dublin in 1995 with a first class honours degree in Cell Biology and Molecular Genetics. She then carried out her PhD. training at the Adrinodack Biomedical Research Institute, Lake Placid, New York and at the University of Notre Dame, Indiana in cancer cell biology. In 2000, she moved to the University of Washington, Seattle as a NIH funded fellow where she investigated how genomic instability events are crucial in driving disease progression in inflammatory diseases. In 2003, Jacintha returned to Dublin to the Centre for Colorectal Disease, St. Vincents University Hospital as a senior scientist to work with a multidisciplinary colorectal cancer team and to establish a translational colorectal cancer research program. Currently she directs two upper GI research programs in Barretts Oesophagus and Colorectal Cancer in the Department of Surgery, St. Jamess Hospital / TCD in collaboration with her surgical and clinical colleagues.

Her research interests include: Cellular instability and GI disease progression, Drug screening to search for new therapeutics, The role of the tumour micro environment in modulating disease progression and treatment sensitivity in GI cancers.

She has received grant funding from the Health Research Board, Irish Cancer Society and Science Foundation Ireland and from different industry sponsors. She has acted as a council member of the Irish Association for Cancer Research (IACR) from 2008-2012 and has been elected as honorary secretary for (2012-2015). She has supervised many MD, master and PhD thesis to completion.

Dr. O Sullivan has established a strong scientific track record in the field of gastrointestinal cancers and inflammatory conditions with publications (66 in total) in high impact journals such as Nature Genetics, Human Molecular Genetics and Journal of Clinical Oncology.


RECENT PUBLICATIONS


1. Phelan JJ, O’Hanlon C, Reynolds JV, O’Sullivan J. The role of energy metabolism in driving disease progression in inflammatory, hypoxic and angiogenic microenvironments. Gastro Open J. 2015; 1(2): 44-58. doi: 10.17140/GOJ-1-108

Varayu Prachayakul, MD

Assistant Professor
Division of Gastroenterology
Department of Internal Medicine
Faculty of Medicine, Siriraj Hospital, Mahidol University
Bangkok 10700, Thailand

BiographyResearch InterestScientific ActivitiesPublications

After complete the Clinical fellowship training in advanced therapeutic endoscopy (ERCP) and Endosonography at Interdisciplinary endoscopic unit, University of Hamburg-Eppendorf, Hamburg Germany in 2008, Dr. Prachayakul, been working on advanced therapeutic endoscopy at Siriraj GI Endoscopy center, Siriraj hospital, Mahidol university. He had published some case reports, case series and articles regarded; gastrointestinal bleeding, colon cancer screening, endoscopic ultrasound (EUS) in both diagnosis and therapeutic procedures, endoscopic retrograde cholangiopan creatography (ERCP) which also included cholangioscopy / pancreatoscopy and single balloon assisted enteroscopy. Dr. Prachayakul, currently work on all the treatments and procedures mentioned above. His personal interest are the development of new techniques and accessories to aid the treatments in advanced therapeutic procedures; such as a self-made Teflon catheters for graded dilatation used in EUS guided biliary drainage.

His research interests include: Gastrointestinal bleeding, gastrointestinal malignancy (such as cholangiocarcinoma and pancreatic cancer), ERCP and EUS techniques and instruments, enteroscopy, colon cancer and colon cancer screening.

HONORS

• Award for the outstanding medical student, 1993
• Medical degree with second class honor, 1993

1. Prachayakul V, Jarasjareunwittaya P, Pongprasopchai S, et al. Comparison of clinical, biochemical, virological and histopathological characteristics between chronic hepatitis C infected patients with respect to genotype 1 and 3. Thai J Gastroenterol. 2005; 6: 72-80.
2. Akaraviputh T, Sriprayoon T, Prachayakul V, Sakiyalak P. Endoscopic diagnosis of secondary aortoesophageal fistula. Endoscopy. 2008; 40(Suppl 2): E90.
3. Pongprasobchai S, Jianjaroonwong V, Charatcharoenwitthaya P, et al. Erythrocyte sedimentation rate and C-reactive protein for the prediction of severity of acute pancreatitis. Pancreas. 2010; 39(8): 1226-1230.doi: : 10.1097/MPA.0b013e3181deb33e
4. Prachayakul V, Aswakul P, Kachinthorn U. Spraying N-butyl-2-cyanoacrylate (Histoacryl) as a rescue therapy for gastrointestinal malignant tumor bleeding after failed conventional therapy. Endoscopy. 2011; 43(Suppl 2): E227-E228. doi: 10.1055/s-0030-1256350
5. Prachayakul V, Aswakul P, Kachinthorn U. Tapered-tip Teflon catheter: another device for sequential dilation in endoscopic ultrasound-guided hepaticogastrostomy. Endoscopy. 2011; 43(Suppl 2): E213-E214. doi: 10.1055/s-0030-1256395
6. Prachayakul V, Aswakul P, Kachintorn U. Bleeding hepaticojejunostomy anastomotic varices successfully treated with Histoacryl injection, using single-balloon enteroscopy. Endoscopy. 2011; 43(Suppl 2): E153. doi: 10.1055/s-0030-1256233
7. Prachayakul V, Aswakul P, Kachintorn U. EUS-guided choledochoduodenostomy for biliary drainage using tapered-tip plastic stent with multiple fangs. Endoscopy. 2011; 43(Suppl 2): E109-E110. doi: 10.1055/s-0030-1256140.
8. Prachayakul V, Aswakul P, Kachintorn U. Atypical clinical presentation of typical endoscopic finding of Bouverets syndrome. Endoscopy. 2011; 43(Suppl 2): E55-E56. doi: 10.1055/s-0030-1256059
9. Prachayakul V, Aswakul P, Kachintorn U. Common bile duct stone removal with overtube-assisted direct peroral cholangioscopy, without balloon inflation, using an ultra-slim gastroscope following electrohydraulic lithotripsy. Endoscopy. 2011; 43(Suppl 2): E273-E274. doi: 10.1055/s-0030-1256351
10. Prachayakul V, Aswakul P, Kachintorn U. Overtube-assiste direct peroral pancreatoscopy using an ultraslim gastroscope in a patient suspected of having and intraductal papillary mucinous neoplasm. Endoscopy. 2011; 43(Suppl 2): E279-E280. doi: 10.1055/s-0030-1256351
11. Prachayakul V, Aswakul P, Kachintorn U. Complete obstructive esophageal cancer with esophagopleural fistula successfully treated by combined antegrade and retrograde rendezvous technique. Endoscopy. 2011; 43(Suppl 2): E354-E355. doi: 10.1055/s-0030-1256858
12. Prachayakul V, Aswakul P, Limsrivilai J, et al. Benefit of “transparent soft-short-hood on the scope” for colonoscopy among experienced gastroenterologists and gastroenterologist trainee: a randomized, controlled trial. Surg Endosc. 2012; 26(4): 1041-1046. doi: 10.1007/s00464-011-1992-7
13. Prachayakul V, Aswakul P, Kachintorn U. Incidental removal of distal common bile duct adenoma after plastic stent placement. Endoscopy. 2012; 44(Suppl 2): E11-E12. doi: 10.1055/s-0031-1291497
14. Prachayakul V, Aswakul P, Kachintorn U. Duodenal perforation due to plastic stent migration successfully treated by endoscopy. Gastrointest Endosc. 2012; 75(6): 1265-1266. doi: 10.1016/j.gie.2012.01.036
15. Prachayakul V, Aswakul P, Kachintorn U. EUS guided fine needle aspiration cytology of liver nodules suspicious for malignancy: yields, complications and impact on management. J Med Assoc Thai. 2012; 95(Suppl 2): S56-S60.
16. Prachayakul V, Aswakul P, Pongprasobchai S, et al. Clinical characteristics, endosonographic findings and etiologies of gastroduodenal subepithelial lesions: a Thai referral single center study. J Med Assoc Thai. 2012; 95(Suppl 2): S61-S67.
17. Prachayakul V, Sriprayoon T, Asawakul P, Pongprasobchai S, Pausawasdi N, Kachintorn U. Repeated endoscopic ultrasound guided fine needle aspiration (EUS-FNA) improved diagnostic yield of inconclusive initial cytology for suspected pancreatic cancer and unknown intra-abdominal lymphadenopathy. J Med Assoc Thai. 2012; 95(Suppl 2): S68-S74.
18. Prachayakul V, Aswakul P, Apisarnthanarak P, Pongprasobchai S. Diffuse type autoimmune pancreatitis: the first case report in Thailand. J Med Assoc Thai. 2012; 95(Suppl 2): S261-4.
19. Aswakul P, Prachayakul V, Lohsiriwa V, Bunyaarunnate T, Kachintorn U. Screening colonoscopy from a large single center of Thailand-something needs to be changed? Asian Pac J Cancer Prev. 2012; 13(4): 1361-1364.
20. Prachayakul V, Aswakul P, Leelakusolvong S. Endoscopic ultrasound-guided transgastric biliary metal stent placement after dukatuib with tapered-tip Tefkib catgeters abd marking with a clip. Endoscopy. 2012; 44(Suppl 2): E329-E330. doi: 10.1055/s-0032-1309857
21. Prachayakul V, Aswakul P. Successful endoscopic treatment of iatrogenic biloma as a complication of endosonographygiuded hepaticogastrostomy: The first case report. J Interv Gastroenterol. 2012; 2: 202-204.
22. Phisalprapa P, Prachayakul V. Ascariasis as an unexpected cause of acute pancreatitis with cholangitis: a rare case report from urban area. JOP. 2013; 14(1): 88-91. doi: 10.6092/1590-8577/1257.
23. Prachayakul V, Aswakul P, Deesomsak M, Pongpaibul A. Gastric pancreatic heterotopia: an unusual cause of upper gastrointestinal bleeding. Endoscopy. 2013; 45(Suppl 2): E7-E8. doi: 10.1055/s-0032-1326120
24. Prachayakul V, Aswakul P, Leelakusolvong S. Massive gastric antral vascular ectasia successfully treated by endoscopic band ligation as the initial therapy. World J Gastrointest Endosc. 2013; 5(3): 135-137. doi: 10.4253/wjge.v5.i3.135
25. Prachayakul V, Chaisayan S, Aswakul P, Deesomsak M. Clinical characteristics and treatment outcomes of patients with unresectable cholangiocatrcinoma in Thailand: are there differences dependent on stent type? Asian Pac J Cancer Prev. 2013; 14(1): 529-532.
26. Sirimontaporn N, Aswakul P, Junyangdikul P, Prachayakul V. Early neoplasia of the common bile duct diagnosed and completely removed using multiple endoscopic modalities. Endoscopy. 2013; 45(Suppl 2): E102-E103. doi: 10.1055/s-0032-1326278.
27. Prachayakul V, Aswakul P, Deesomsak M, pongpaibul A. Multifocal plasmacytoma presenting with upper gastrointestinal bleeding, chronic diarrhea, and multiple sites of small-bowel intussusception. Endoscopy. 2013; 45(Suppl 2): E84-E85. doi: 10.1055/s-0032-1326262
28. Pongprasobchai S, Lertwattanarak R, Pausawasdi N, Prachayakul V. Diagnosis and localization of insulinoma in Thai patients: performance of endoscopic ultrasonography compared to computed tomography and magnetic resonance imaging. J Med Assoc Thai. 2013; 96(Suppl 2): S187-S193.
29. Aswakul P, Prachayakul V. Tropical sprue: two cases report and review of literature. Has anything changed in the past 40 years? J Med Assoc Thai. 2013; 96(Suppl 2): S266-S269.
30. Prachayakul V, Aswakul P. Successful endoscopic treatment of iatrogenic biloma as a complication of endosonography guided hepaticogastrostomy: The first case report. J Interv Gastroenterol. 2012; 2(4): 202-204.
31. Prachayakul V, Aswakul P, Chantarojanasiri T, Leelakusolvong S. Factors influencing clinical outcomes of Histoacryl(R) glue injection-treated gastric variceal hemorrhage. World J Gastroenterol. 2013; 19(15): 2379-2387.doi: 10.3748/wjg.v19.i15.2379.
32. Prachayakul V, Aswakul P. Failure of sequential biliary stenting for unsuccessful common bile duct stone removal. World J Gastrointest Endosc. 2013; 5(6): 288-292. doi: 10.4253/wjge.v5.i6.288.
33. Prachayakul V, Deesomsak M, Aswakul P, Leelakusolvong S. The utility of single-balloon enteroscopy for the diagnosis and management of small bowel disorders according to their clinical manifestations: a retrospective review. BMC Gastroenterol. 2013; 13(1): 1-7. doi: 10.1186/1471-230X-13-103
34. Aswakul P, Janyangdikul P, Prachayakul V. Thickened esophagus as an unusual manifestation of eosinophilic esophagitis. Dis Esophagus. 2013. doi: 10.1111/dote.12044
35. Prachayakul V, Aswakul P. A novel technique for endoscopic ultrasound-guided biliary drainage. World J Gastroenterol. 2013; 19(29): 4758-4763. doi: 10.3748/wjg.v19.i29.4758.
36. Prachayakul V, Thamtorawat S, Siripipattanamongkol C, Thanathanee P. Bleeding left hepatic artery pseudoaneurysm: a complication of endoscopic ultrasound-guided hepaticogastrostomy. Endoscopy. 2013; 45 (Suppl 2): E223-E224. doi: 10.1055/s-0033-1344064
37. Prachayakul V, Aswakul P, Deesomsak M, Pongpaibul A. Gastric somatostatinoma: an extremely rare cause of upper gastrointestinal bleeding. Clin Endosc. 2013; 46(5): 582-585. doi: 10.5946/ce.2013.46.5.582
38. Prachayakul V, Aswakul P. Tapered-tip catheter dilatation: a safe technique for EUS-guided transesophageal drainage of peripancreatic fluid collections. J Interv Gastroenterol. 2013; 3(1): 31-33.
39. Prachayakul V, Aswakul P, Kachintorn U. Electrohydraulic lithotripsy as an highly effective method for complete large common bile duct stone clearance. J Interv Gastroenterol. 2013; 3(2): 59-63.
40. Prachayakul V, Phisalprapa P, Aswakul P. Infected Walled-Off Pancreatic Necrosis following EUS-Guided Drainage Successfully Treated Using Multiple Stents in Different Sites Technique. Case Rep Gastroenterol. 2013; 7(3): 404-408. doi: 10.1159/000355347
41. Deesomsak M, Aswakul P, Junyangdikul P, Prachayakul V. Rare adult gastric duplication cyst mimicking a gastrointestinal stromal tumor. World J Gastroenterol. 2013; 19(45): 8445-8448. doi: 10.3748/wjg.v19.i45.8445
42. Prachayakul V. Current Status of Endoscopic Treatment of Advanced Hilar Cholangiocarcinoma. J Gastroint Dig Syst. 2014; 4: 168. doi: 10.4172/2161-069X.1000168
43. Deesomsak M, Sawanyawisuth K, Prachayakul V. An unusual cause of chronic diarrhoea. Trop Biomed. 2014; 31(1): 187-189.
44. Prachayakul V, Aswakul P, Bhunthumkomol P, Deesomsak M. Diagnostic yield of endoscopic ultrasonography in patients with intermediate or high likelihood of choledocholithiasis: a retrospective study from one university-based endoscopy center. BMC Gastroenterol. 2014; 14: 165. doi: 10.1186/1471-230X-14-165

S. Houssam Mardini, MD, MBA, MPH

Assistant Professor of Medicine, Clinical Title Series Director of Endoscopy
Division of Gastroenterology
Department of Internal Medicine
UK HealthCare
University of Kentucky College of Medicine
800 Rose Street, Room MN649
Lexington, KY 40536, USA

BiographyResearch InterestScientific ActivitiesPublications
PROFESSIONAL/GRADUATE

• (09/1986-09/1992): Diploma of Doctor in Medicine (MD), Damascus University School of Medicine, Damascus, Syria
• (08/2002-04/2003): Master of Public Health (MPH), University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA
• (08/2008-12/2010): Master of Business Administration (MBA), University of Kentucky Gatton College of Business and Economics , Lexington, KY
• (01/2013-12/2013): Master of Business Administration (MBA), Marshall University Lewis College of Business, Huntington, WV


POST-GRADUATE

• (02/1995-12/1996): House Officer, Damascus University Cardiovascular Surgery Center, Damascus, Syria
• (01/1997-06/1997): International Scholarship, The Cleveland Clinic Foundation, Cardiovascular Surgical Unit, Cleveland, OH, Temple University at Frankford Hospital, Philadelphia, PA
• (07/1998-06/1999): Internship, Transitional Year, University of Pittsburgh Medical Center Hospitals, Department of Internal Medicine, Pittsburgh, PA
• (07/1999-04/2000): Internship, Internal Medicine, University of Pittsburgh Medical Center Hospitals, Department of Internal Medicine, Pittsburgh, PA
• (05/2000-04/2002): Residency, Internal Medicine, University of Kentucky Medical Center, Division of Digestive Diseases and Nutrition, Lexington, KY
• (07/2003-06/2006): Fellowship, Gastroenterology, Medical University of South Carolina, Division of Gastroenterology and Hepatology, Charleston, SC
• (07/2011-12/2011): Advanced Endoscopy Training


PROFESSIONAL EXPERIENCES

• Syrian Army and Armed Forces, 82nd Armored Brigade, 3rd Armored Division, Al-Qutayfah, Syria
• (11/1992-01/1995): Lieutenant and Medical Unit Director, University of Kentucky College of Medicine, Division of Digestive Diseases and Nutrition, Lexington, KY
• (07/2006-10/2008): Assistant Professor of Medicine, Mardini & Associates, MD, PSC, Ashland, KY
• (11/2008-10/2013): Gastroenterologist and Owner, Medical University of South Carolina, Division of Gastroenterology and Hepatology, Charleston, SC
• (07/2011-12/2011): Instructor of Medicine, Marshall University Joan C. Edwards School of Medicine, Department of Internal Medicine, Huntington, WV
• (04/2012-06/2013): Associate Professor of Medicine, Cabell Huntington Hospital, Huntington, WV
• (02/2013-08/2013): Director of Endoscopy, Lexington VA Medical Center, Lexington, KY
• (11/2013-Present): Staff Gastroenterologist (Part-time), University of Kentucky College of Medicine, Division of Digestive Diseases and Nutrition, Lexington, KY
• (12/2013- Present): Assistant Professor of Medicine (Part-time), University of Kentucky Healthcare System, Lexington, KY
• (08/2014 – Present): Director of Endoscopy


ACADEMIC APPOINTMENTS

• University of Kentucky College of Medicine, Division of Digestive Diseases and Nutrition, Lexington, KY
• (07/2006-10/2008): Assistant Professor of Medicine, Medical University of South Carolina, Division of Gastroenterology and Hepatology, Charleston, SC
• (07/2011-12/2011): Instructor of Medicine, Marshall University Joan C. Edwards School of Medicine, Department of Internal Medicine, Huntington, WV
• (04/2012-06/2013): Associate Professor of Medicine, University of Kentucky College of Medicine, Division of Digestive Diseases and Nutrition, Lexington, KY
• (12/2013-Present): Assistant Professor of Medicine (Part-time)

His research interests include: Endoscopy including advanced and interventional endoscopy, pancreatic disease and Inflammatory Bowel Disease.

HONORS & AWARDS

• 01/1997, The Cleveland Clinic Foundation International Scholarship (4 months)
• 05/2000, Intern of the Year, University of Pittsburgh Medical Center, Shadyside
• 05/2001, Investing in the Future: AGA/Wyeth-Ayerst Resident and Fellows Reporter Program
• 05/2002, Senior Resident of the Year, University of Pittsburgh Medical Center, Shadyside
• 10/2003, American College of Gastroenterology / Centocor IBD Abstract Award
• 03/2004, 14th Annual North American Conference award of Gastroenterology Fellows (NACGF)
• 04/2004, Ninth Annual Young Investigators award Conference in Digestive Diseases
• 10/2004, American College of Gastroenterology / Centocor IBD Abstract Award
• 02/2010, Americas Top Physician: Consumers Research Counsel
• 09/2012, Caring Spirit All Stars Award: Cabell Huntington Hospital
• 05/2013, Academic Citizenship Excellence Award: Marshall University School of Medicine


COMMITTEES:

• 2014-Present: American College of Gastroenterology Minority Affairs and Cultural Diversity Committee
• 2014-Present: University of Kentucky HealthCare System Endoscopy Executive Committee


MEMBERSHIPS

• 2006-Present Fellow of the American College of Physicians (FACP)
• 2008-Present Member of the European Society of Gastrointestinal Endoscopy
• 2012-Present Member of the International Association of Medical Science Educators
• 2013-Present Fellow of the American Society for Gastrointestinal Endoscopy (FASGE)
• 2013-Present Fellow of the American College of Gastroenterology (FACG)
• 2014-Prenent Fellow of the American Gastroenterological Association (AGAF)

PEER-REVIEWED ORIGINAL RESEARCH IN PROFESSIONAL, SCIENTIFIC OR EDUCATIONAL JOURNALS

1. Mardini HE, Arnold GL. Barretts esophagus-associated polypoid dysplasia: a case report and review of the literature. Digestive Diseases and Sciences. 2002; 47(8): 1897-1900. doi: 10.1111/j.1572-0241.2000.02414.x
2. Regueiro MD, Mardini H. Determination of thiopurine methyltransferase genotype or phenotype optimizes initial dosing of azathioprine for the treatment of Crohns disease. Journal of Clinical Gastroenterology. 2002; 35(3): 240-244. doi: 10.1097/00004836-200209000-00008
3. Mardini HE, Arnold GL. Utility of measuring 6-methylmercaptopurine and 6-thioguanine nucleotide levels in managing inflammatory bowel disease patients treated with 6-mercaptopurine in a clinical practice setting. Journal of Clinical Gastroenterology. 2003; 36(5): 390-395.
4. Mardini H, Regueiro MD. Treatment of Perianal Fistulizing Crohns Disease With Infliximab Alone or As An Adjunct To Exam Under Anesthesia. Inflammatory Bowel Diseases. 2003; 9(2): 98-103.
5. Mardini HE, Kip KE, Wilson JW. Crohns Disease: A Two-Year Prospective Study of the Association Between Psychological Distress and Disease Activity. Digestive Diseases and Sciences. 2004; 49(3): 492-497. doi: 10.1023/B:DDAS.0000020509.23162.cc
6. Tabas GH, Beaves MR, Wang J, Friday PJ, Mardini H, Arnold GL. Paroxetine to Treat Irritable Bowel Syndrome Not Responding to High-Fiber Diet: A Double-Blind, Placebo-Controlled Trial. The American Journal of Gastroenterology. 2004; 99(5): 914-920. doi: 10.1111/j.1572-0241.2004.04127.x
7. Pena LR, Mardini HE, Nickl NJ. Development of an instrument to assess and predict satisfaction and poor tolerance among patients undergoing endoscopic procedures. Digestive Diseases and Sciences.2005; 50(10): 1860-1871. doi: 10.1007/s10620-005-2952-7
8. Mardini HE, Gregory K, Nasser M, et al. Gastroduodenal Crohns Disease is Associated with NOD2/CARD15 Gene Polymorphisms Particularly L1007P Homozygosity. Digestive Diseases and Sciences.2005; 50(12): 2316-2322. doi: 10.1007/s10620-005-3054-2
9. Pena LR, Mardini HE, Nickl N. An Instrument to Predict Endoscopy Tolerance: A Prospective Randomized Study. Digestive Diseases and Sciences.2007; 52(10): 2888-2891. doi: 10.1007/s10620-007-9797-1
10. Knopp TC, Mardini HE, Pena LR. Wireless Capsule Endoscopy Indication as a Predictor of Study Quality. Digestive Diseases and Sciences.2009; 53(7): 1898-1901. doi: 10.1007/s10620-007-0091-z
11. Mardini HE, Grigorian AY, Selby LA, Barrett TA. Anti-TNF Agents Prevent Endoscopic and Clinical Recurrence of Crohns Disease after Surgical Resection: A Systematic Review and A Meta-Analysis. American Journal of Digestive Disease.2014; 1(1): 50-61.
12. Mardini HE, Grigorian AY. Probiotic Mix VSL#3 is Effective Adjunctive Therapy for Mild to Moderately Active Ulcerative Colitis: A Meta-Analysis. Inflammatory Bowel Diseases.2014; 20(9): 1562-1567. doi: 10.1097/MIB.0000000000000084

Francesco Cellini, MD

Assistant Professor
Department of Radioterapia Oncologica
University Campus Bio-Medico
Rome, Italy

BiographyResearch InterestScientific ActivitiesPublications

Dr. Cellini was graduated in 2001 at Medicine Faculty of Universita Cattolica del S.Cuore in Roma, Italy; In 2001 he attended for a period of study the Radiotherapy Department of M.D. Anderson Cancer Centre in Huston, Texas, USA; He has completed his residency in Radiotherapy between 2001- 2005 at Radiotherapy Department of Universita Cattolica del S.Cuore in Roma, Italy. During the residency in Radiotherapy was involved as secretary of the Quality Assurance Program at Radiotherapy Department of Universita Cattolica del S.Cuore in Roma, Italy; In 2004, he attended for a period of study the Radiotherapy Department of the Loyola University in Chicago, Illinois, USA. Since 2005 he is Assistant Professor at Department of Radiation Oncology of Universita Campus Bio-Medico, Roma, Italy.

His research interests include: Gastrointestinal tumours, Gynaecological tumours; Palliative treatments; Trends in Radiotherapy management; new technologies in Radiotherapy; Biological Targeted therapies associated to Radiotherapy; Radiological imaging associated to Radiotherapy.

In the year 2004, Dr. Cellini was a teacher in national and residential courses on Radiotherapy.
Dr. Cellini, since 2005 was involved as teacher at the Medicine Faculty, Residency School of Radiotherapy, and Faculty for Radiation Technologist of University Campus-Bio-Medico in Rome, Italy. He was also involved in tutoring and supervision of medical students, fellows and technologist students.
In 2010 he was a member of the teaching faculty in a Course organized by the International Atomic Energy Agency (IAEA) and African Regional Cooperative Agreement for Research, Development and Training (AFRA): Regional Training Course on Evidence Based Treatment of Head and Neck Cancer (Accra, Ghana)
He is a active member of the European Society for Radiotherapy and Oncology (ESTRO); in 2012 he gained the ESTRO Fellowship as well as in 2012 was selected for the ESTRO Agor - Future Leader Retreat, provided by ESTRO to promote the involvement of young European scientists in the European Society of Radiotherapy.
Dr. Cellini is also active in the Scientific Research; he was involved as investigator at national and international trials. He has authored more than 60 publications; Editor of 2 published books and author of 6 book chapters.
He spent the year 2011-2012 working at Radiotherapy Department of the Maastro Clinic, Maastricht, The Netherlands, in developing research projects on the implementation of imaging modalities for developing predictive assays in Radiotherapy.

1. Cellini F, Morganti AG, Di Matteo FM, Mattiucci GC, Valentini V. Clinical management of gastroesophageal junction tumors: past and recent evidences for the role of radiotherapy in the multidisciplinary approach. RadiatOncol. 2014; 9(1): 45. doi: 10.1186/1748-717X-9-45
2. Cerezo L, Ciria JP, Arbea L, et al. Current treatment of rectal cancer adapted to the individual patient. Reports Of Practical Oncology And Radiotherapy doi: 10.1016/j.rpor.2013.08.005
3. Cellini F, Valentini V. Targeted Therapies in Combination with Radiotherapy in Oesophageal and Gastroesophageal Carcinoma. Current Medicinal Chemistry. 2013; doi: 10.2174/09298673113209990236
4. Morganti AG, Di Castelnuovo A, Massaccesi M, et al. Planning comparison between standard and conformal 3D techniques in post-operative radiotherapy of gastric cancer: a systematic review. British Journal of Radiology. 2013; doi: 10.1259/bjr.20130274
5. Chiesa S, Balducci M, Azario L, et al. Development of a Modelling to Correlate Site and Diameter of Brain Metastases with Hippocampal Sparing Using Volumetric Modulated Arc Therapy. Biomed Research International. 2013; doi: 10.1155/2013/568597
6. Cellini F, Vincenzi B. The variation in treating colorectal cancer between Europe and America. Colorectal Cancer. 2013; 2: 177-180.
7. Valentini V, Cellini F, Gambacorta MA. Preoperative treatment for locally advanced rectal cancer: is there enough evidence to define the preferable radiotherapy schedule? Colorectal Cancer. 2013; 2: 379-382.
8. Del Vescovo R, Trodella LE, Sansoni I, et al. MR imaging of rectal cancer before and after chemoradiation therapy. La Radiologia Medica. 2012; 117: 1125-1138.
9. Ramella S, Trodella L, Ippolito E, et al. Whole-breast irradiation: a subgroup analysis of criteria to stratify for prone position treatment. Medical Dosimetry. 2012; 37: 186-191. doi: 10.1016/j.meddos.2011.06.010
10. Cellini F, Valentini V. Sphincter preservation in the treatment of locally advanced rectal cancers. Oncology-New York. 2012; 26: 872
11. Valentini V, Cellini F. Management of local rectal cancer: evidence, controversies and future perspectives in radiotherapy. Colorectal Cancer. 2012; 1: 163-177. doi: 10.2217/crc.12.6
12. Cellini F, Valentini V. Current perspectives on preoperative integrated treatments for locally advanced rectal cancer: a review of agreement and controversies. Oncology-New York. 2012; 26: 730.
13. Valentini V, Cellini F, Barba MC, van Stiphout R. Do Different Populations of Rectal Cancer Exist? Multidisciplinary Management of RectalCancer. 2012; 49-55 doi: 10.1007/978-3-642-25005-7_6
14. Balducci M, Chiesa S, Manfrida S, et al. Impact of radiotherapy on pain relief and recalcification in plasma cell neoplasms: long-term experience. Strahlentherapie Und Onkologie. 2011; 187: 114-119. doi: 10.1007/s00066-010-2155-9
15. Ramella S, Trodella L, Mineo TC, et al. Beams arrangement in Non Small Cell Lung Cancer (NSCLC) according to PTV and dosimetric parameters predictive of pneumonitis. Medical Dosimetry. 2010. doi: 10.1016/j.meddos.2009.05.003
16. Ramella S, Trodella L, Mineo TC, et al. Adding ipsilateral V20 and V30 to conventional dosimetric constraints predicts radiation pneumonitis in NSCLC stage IIIA-B treated with combined modality therapy. International Journal of Radiation Oncology Biology Physics. 2010. doi: 10.1016/j.ijrobp.2009.01.036
17. Valentini V, Cellini F, Minsky BD, et al. Survival after radiotherapy in gastric cancer: systematic review and meta-analysis of published literature. Radiotherapy and Oncology. 2009; 92(2): 176–183 doi: 10.1016/j.radonc.2009.06.014
18. Ciresa M, Angelillo RMD, Ramella S, et al. Molecularly targeted therapy and radiotherapy in the management of localized gastrointestinal stromal tumor (GIST) of the rectum: a case report. Tumori. 2009.
19. Annibali O, Nobile C, Greco R, et al. The combination topotecan, temozolomide and dexamethasone associated with radiotherapy as treatment of central nervous system myeloma relapse. International Journal of Hematology. 2009; doi: 10.1007/s12185-009-0277-6
20. Piermattei A, Fidanzio A, Azario L, et al. In patient dose reconstruction using a cine acquisition for dynamic arc radiation therapy. Medical and Biological Engineering and Computing. 2009; doi: 10.1007/s11517-009-0456-x
21. Valentini V, Cellini F. Surgery: neoadjuvantchemoradiation and sphincter preservation. Nature reviews. Gastroenterology and Hepatology. 2009; 6: 327-329. doi: 10.1038/nrgastro.2009.83
22. Angelillo RMD, Trodella L, Ciresa M, et al. Multimodality Treatment of Stage III Non-small Cell Lung Cancer - Analysis of a Phase II Trial Using Preoperative Cisplatin and Gemcitabine with Concurrent Radiotherapy. Journal of Thoracic Oncology. 2009; doi: 10.1097/JTO.0b013e3181b9e860
23. Valentini V, Maurizi F, Tagliaferri L, et al. Spider: Managing clinical data of cancer patients treated through a Multidisciplinary Approach by a Palm Based System. Italian Journal of Public Health. 2008; 5: 154-164.
24. Valentini V, Barba MC, Cellini F, Gambacorta MA. Integrated treatment of non surgical neoplasms of rectum. Italian Journal Of Digestive Endoscopy. 2008; 31: 11-17.
25. Angelillo RMD, Trodella L, Ramella S, et al. Novel prognostic groups in thymic epithelial tumors: assessment of risk and therapeutic strategy selection. International Journal of Radiation Oncology Biology Physics. 2008; doi: 10.1016/j.ijrobp.2007.10.006
26. Fidanzio A, Mameli E, Placidi F. et al. Epid cine acquisition mode for in vivo dosimetry in dynamic arc radiation therapy. Nuclear Instruments and Methods in Physics Research. Section B, Beam Interactions with Materials and Atoms. 2008; doi: http://dx.doi.org/10.1016/j.nimb.2007.11.038
27. Piermattei A, Stimato G, Gaudino D, et al. Dynamic conformal arc therapy: transmitted signal in vivo dosimetry. Medical Physics. 2008;
28. Valentini V, Cellini F. The L shape of survival curve in gastric cancer. Tumori. 7: s40-s42. 2008;
29. Piermattei A, Fidanzio A, Azario L, et al. Application of a practical method for the isocenter point in vivo dosimetry by a transit signal. Physics in Medicine and Biology. 2007; doi: 10.1088/0031-9155/52/16/026
30. Caricato M, Ausania F, DeDominicis E, et al. Tumor regression in mesorectallymphnodes after neoadjuvantchemoradiation for rectal cancer. European Journal of Surgical Oncology. 2007; doi: http://dx.doi.org/10.1016/j.ejso.2007.01.023
31. Valentini V, Cellini F. Radiotherapy in gastric cancer: a systematic review of literature and new perspectives. Expert Review of Anticancer Therapy. 2007; 7(10): 1379-1393. doi: 10.1586/14737140.7.10.1379
32. Trodella L, De Marinis F, Angelillo RMD, et al. Induction cisplatin-gemcitabine-paclitaxel plus concurrent radiotherapy and gemcitabine in the multimodality treatment of unresectable stage IIIB non-small cell lung cancer. Lung Cancer. 2006; 54(3):331-338. doi: http://dx.doi.org/10.1016/j.lungcan.2006.07.020
33. Trodella L, Dangelillo RM, Ramella S, Cellini F, Ciresa M, Fiore M. Radiation Oncology: Yesterday, Today and Tomorrow. Medic Teaching Methodology And Innovation Clinic 2006; 14: 95-102.
34. Trodella L, Angelillo RMD, Ramella S, et al. Chemo-radiotherapy in non-small cell lung cancer: the role of gemcitabine. Annals of Oncology. 2006; 17 Suppl 5: v52-v54.doi: 10.1093/annonc/mdj950
35. Mantini G, Manfrida S, Cellini F, et al. Impact of dose and volume on radiation-induced mucositis. Rays. 2005; 30: 137-144.
36. Cellini F, Ramella S, Ciresa M, et al. Role of induction therapy in esophageal cancer. Rays. 2005; 30: 329-333.
37. Valentini V, Cellini F and Angelillo RMD. Combined treatments in gastric cancer: radiotherapy. I Supplementi Di Tumori. 2003; 2: s39-s44
38. Cellini F, Valentini V, Pacelli F, et al. Preoperative radiotherapy in gastric cancer: CTV definition for conformal therapy according to tumor location. Rays. 2003; 28: 317-329.
39. Cellini N, Luzi S, Morganit AG, et al. Biological factors and therapeutic modulation in prostate cancer radiotherapy. Rays. 2002; 27: 205-214.
40. V. Valentini, C. Coco, A. Picciocchi, et al. Does downstaging predict improved outcome after preoperative chemoradiation for extraperitoneal locally advanced rectal cancer? A long-term analysis of 165 patients. International Journal of Radiation Oncology Biology Physics. 2002; 53(3):664-674. doi: http://dx.doi.org/10.1016/S0360-3016(02)02764-5
41. Valentini V, Piermattei A, Marchetti M, et al. Quality handbook in radiotherapy: personal experience. Rays. 2001; 26(3): 205-8.

Ivo Boškoski, MD, PhD

Gastroenterology & Digestive Endoscopy
Digestive Endoscopy Unit
Catholic University of Rome
Largo A. Gemelli, 00168 Roma, Italy

BiographyResearch InterestScientific ActivitiesPublications

Dr. Boškoski has qualified MD at the University of Perugia, Italy, in 2005. He completed his Residency in Gastroenterology and Digestive Endoscopy at the Campus Bio-Medico University of Rome in 2009 and he undertook PhD training on Endoscopic Treatment of Obesity on the Catholic University of Rome, which he completed in 2012. Since 2007, He trained diagnostic and operative gastrointestinal endoscopy and biliopancreatic endoscopy with a fellowship at the Digestive Endoscopy Unit of the Catholic University of Rome, directed by Professor Guido Costamagna, where present he is Instructor and Member of the faculty of the European Endoscopy Training Center. His particular interest is in inventing and development of simulators for diagnostic and operative ERCP and new endoscopic devices. He has authored and co-authored many peer reviewed publications, text book chapters and abstracts, and he has lectured at many national and international meetings. He is also co-investigator of fifteen clinical trials at the Catholic University of Rome, Italy.

His research interests include: Biliopancreatic endoscopy and ERCP, including the endoscopic management of post-operative complications, biliopancreatic malignancy, chronic pancreatitis and its complications and biliopancreatic extracorporeal shock wave lithotripsy.

MEMBERSHIP

• Medical Council of Latina, Italy
• European Society of Gastrointestinal Endoscopy (ESGE)
• Italian Society of Digestive Endoscopy (SIED)
• Italian Society of Young Gastroenterologists (AGGEI)
• Italian Society of Ultrasonology in Medicine and Biology (SIUMB)

1. Lacopini F, Bizzotto A, Boskoski I, Bulajic M, Costamagna G. Epidemiology and management of diverticular disease of the colon. Aging Health. 2007; 3(4): 551-566 doi: 10.2165/00002512-200421040-00001
2. Urgesi R, Riccioni ME, Spada C, Boskoski I, Costamagna G. Video capsule endoscopy in patients with suspected small bowel stenosis. GIED. 2007; 30(3): 253-258
3. Tringali A, Boskoski I, Costamagna G. The role of endoscopy in the therapy of chronic pancreatitis. Best Pract Res Clin Gastroenterol. 2008; 22(1): 145-65. doi: 10.1016/j.bpg.2007.10.021
4. Caviglia R, Boskoski I, Cicala M. Long-term treatment with infliximab in inflammatory bowel disease: safety and tolerability issues. Expert Opin Drug Saf. 2008; 7 (5): 617-32. doi: 10.1517/14740338.7.5.617
5. Caviglia R, Boskoski I, Cicala M. Maintenance treatment with infliximab for the management of Crohns disease in adults. Biologics: Targets & Therapy. 2009; 3: 39-49 doi: http://dx.doi.org/10.2147/BTT.S3663
6. Boskoski I, Tringali A, Familiari P, Mutignani M, Costamagna G. Self-expandable metallic stents for malignant gastric outlet obstruction. Adv Ther. 2010; 27(10): 691-703. doi: 10.1007/s12325-010-0061-2
7. Boskoski I, Costamagna G. What to do when a sphincterotomy bleeds? GIED. 2010; 33(4): 309-311
8. Boskoski I, Tringali A, Familiari P, Costamagna G. An unusual post-ERCP pneumoperitoneum. Dig Liver Dis. 2011; 43(7): 579. doi: 10.1016/j.dld.2011.02.004
9. Perri V, Familiari P, Tringali A, Boskoski I, Costamagna G. Plastic biliary stents for benign biliary diseases. Gastrointest Endosc Clin N Am. 2011; 21(3): 405-33. doi: 10.1016/j.giec.2011.04.012
10. Familiari P, Boskoski I, Marchese M, Perri V, Costamagna G. Endoscopic treatment of obesity. Expert Rev Gastroenterol Hepatol. 2011; 5(6): 689-701.
11. Familiari P, Costamagna G, Blero D, et al. Transoral gastroplasty for morbid obesity: a multicenter trial with a 1-year outcome. Gastrointest Endosc. 2011; 74(6): 1248-58. doi: 10.1016/j.gie.2011.08.046
12. Costamagna G, Masci E , Boskoski I, Mangiavillano B. Malignant biliary strictures Giornale Italiano di Endoscopia Digestiva. 2012; 35(1): 97-100.
13. Costamagna G, Boskoski I, Familiari P, Tringali A, Cesaro P, Perri V. Update in biliary endoscopy. Dig Dis. 2011; 29(Suppl 1): 3-8. doi: 10.1159/000331118
14. Familiari P, Hervoso C, Boskoski I, Costamagna G. Doctor, I have a long, sausage-shaped lump in my abdomen. Gastrointest Endosc. 2012; 75(5): 1100-1101. doi: 10.1016/j.gie.2012.01.018
15. Perri V, Boskoski I, Tringali A, et al. Fully covered self-expandable metal stents in biliary strictures caused by chronic pancreatitis not responding to plastic stenting: a prospective study with 2 years of follow-up. Gastrointest Endosc. 2012; 75(6): 1271-7. doi: 10.1016/j.gie.2012.02.002
16. Costamagna G, Boskoski I. Stonebreakers: the era of pancreatic stones treatment. Expert Rev Gastroenterol Hepatol. 2012; 6(5): 521-3. doi: 10.1586/egh.12.41
17. Perri V, Boskoski I, Tringali A, et al. Prospective evaluation of the partially covered nitinol ComVi stent for malignant non hilar biliary obstruction. Dig Liver Dis. 2013; 45(4): 305-9. doi: 10.1016/j.dld.2012.11.001
18. Costamagna G, Boskoski I. To Drain or Not to Drain? That Is the Question. Dig Dis Sci. 2013; doi: 10.1007/s10620-013-2633-x.
19. Costamagna G, Boskoski I. Needle-knife electrocautery: Give me a lever and I will move the world. Gastrointest Endosc. 2013; 77(5): 759-60. doi: 10.1016/j.gie.2013.02.026
20. Boskoski I, Tringali A, Landi R, et al. Endoscopic retrieval of a duodenal perforating teaspoon. World J Gastrointest Endosc. 2013; 5(4): 186-8. doi: 10.4253/wjge.v5.i4.186
21. Costamagna, G, Boskoski. I Current treatment of benign biliary strictures. Annals of Gastroenterology. 2013; 26(1):37-40
22. Bove V, Tringali A, Boskoski I, Gigante G, Costamagna G. ESWL-assisted removal of a calcified pancreatic stent. Endoscopy. 2013; 45(Suppl 2): E163 doi: 10.1055/s-0032-1326642
23. Familiari P, Marchese M, Boskoski I, Costamagna G. Peroral endoscopic myotomy safety data. Techniques in Gastrointestinal Endoscopy. 2013; 15(3): 144-148. doi: 10.1016/j.tgie.2013.04.003
24. Familiari P, Marchese M, Gigante G, et al. Peroral endoscopic myotomy for the treatment of achalasia in children. J Pediatr Gastroenterol Nutr. 2013; 57(6): 794-7 doi: 10.1097/MPG.0b013e3182a803f7
25. Boskoski I, Volkanovska A, Tringali A, et al. Endoscopic resection for gastrointestinal neuroendocrine tumors. Expert Rev Gastroenterol Hepatol. 2013; 7(6): 559-69. doi: 10.1586/17474124.2013.816117
26. Scaldaferri F, Gerardi V, Lopetuso LR, et al. Gut microbial flora, prebiotics, and probiotics in IBD: their current usage and utility. Biomed Res Int. 2013; 2013: 435268 doi: 10.1155/2013/435268
27. Familiari P, Boskoski I, Bove V, Costamagna G. ERCP for biliary strictures associated with chronic pancreatitis. Gastrointest Endosc Clin N Am. 2013; 23(4): 833-45. doi: 10.1016/j.giec.2013.06.007.
28. Familiari P, Marchese M, Gigante G, et al. Peroral endoscopic myotomy for the treatment of achalasia in children: Report of 3 cases. Journal of Pediatric Gastroenterology and Nutrition. 2013; 794-797. doi: 10.1097/MPG.0b013e3182a803f7
29. Laterza L, Scaldaferri F, Bruno G, et al. Pancreatic function assessment. Eur Rev Med Pharmacol Sci. 2013; 17(Suppl 2): 65-71.
30. Boskoski I, Tringali A, Familiari P, Bove V, Perri V, Costamagna G. Endoscopic Removal of an Esophageal Stent After Diffuse Hyperplastic Tissue Ingrowth. Video Journal and Encyclopedia of GI Endoscopy .2014;
31. Tringali A, Blero D, Boskoski I, et al. Difficult removal of fully covered Self Expandable Metal Stents (SEMS) for benign biliary strictures: The SEMS in SEMS technique. Dig Liver Dis. 2014; doi: 10.1016/j.dld.2014.02.018
32. Boskoski I, Costamagna I. Walled-off pancreatic necrosis: where are we? Annals of Gastroenterology. 2014; 27: 93-94
33. Familiari P, Gigante G, Marchese M, et al. EndoFLIP system for the intraoperative evaluation of peroral endoscopic myotomy. United European Gastroenterology Journal. 2014; Vol. 2(2): 77-83. doi: 10.1177/2050640614521193

Renato Caviglia, MD, PhD

Consultant
Departemnt of Gastroenterology and Digestive Endoscopy
Jewish Hospital of Rome, Rome, Italy

BiographyResearch InterestScientific ActivitiesPublications
EDUCATIONAL QUALIFICATION:

1993 MD: 110/110 cum laude.
1999 Fellowship in Gastroenterology and Digestive Endoscopy
2004 PhD in Hepato-Gastroenterology


Clinical experience abroad

1993: Department of Medicine: Division of Gastroenterology, Mount Sinai School of Medicine, New York, NY, USA.
1994: St. Bartholomew’s Hospital and Homerton Hospital, London, UK.
2010: Visiting physician at IBD center, Dpt of Gastroenterology and Digestive Endoscopy, Tel Aviv Sourasky Medical Center Israel.


Clinical activity

May 2001-May 2009: Assistant Professor at Department of Digestive Diseases and Endoscopy Unit, University Campus Bio-Medico of Rome, Italy. Responsible Outpatient Clinic for Inflammatory Bowel Disease.
Since May 2009: Consultant at Department of Gastroenterology and Digestive Endoscopy, The Jewish Hospital of Rome, Italy


RESEARCH PROJECTS PERFORMED WITH FINANCIAL GRANTS FROM PHARMACEUTICAL INDUSTRIES:

1. Modification of the expression of the component of GH/IGF1 axis in patients affected by Crohn’s disease: role of the gastrointestinal inflammation and reversibility of the GH/IGF1 axis blockade by anti-TNF treatment.
2. Quantitative analysis with a mathematic model of the MRI post-contrastographic enhancement curves kinetics in Crohn’s disease patients, pre and post anti TNF-α treatment. 3. Evaluation of the bFGF and VEGF epithelial receptor modification with immunochemistry and molecular analysis (PCR), in patients affected by ileal Crohn’s disease treated with anti TNF-α.

His research interests include: Autoimmune disorders of the GI tract; Inflammatory Bowel Disease: diagnosis and treatment with immunosuppressive and biologic anti-TNF α agents; Digestive Endoscopy (Diagnostic and Operative); Peptic ulcer disease and Helicobacter pylori infection; Gastro-oesophageal reflux disease.

ORAL PRESENTATION AT INTERNATIONAL MEETINGS:

1. American Gastroenterology Association: Distinguished abstract plenary session
2. American Gastroenterology Association: Research forum
3. Pancreas Cancer Forum 2008.


SERVED AS CONSULTANT AND SPEAKER FOR THE FOLLOWING PHARMACEUTICAL COMPANIES:

• Schering Plough Corp.
• Abbott
• Sofar
• Giuliani SpA: Member of Indipendent Safety commitee for Fase I GED-301 study: A Phase I, ascending dose, safety/pK study of 7 days oral administration of an oligonucleotide (GED 0301) in patients with Crohn’s disease.

1. Annunziata ML, Caviglia R, Papparella LG, Cicala M. Upper Gastrointestinal Involvement of Crohns Disease: A Prospective Study on the Role of Upper Endoscopy in the Diagnostic Work-Up. Dig Dis Sci. 2012; 57(6):1618-1623. doi: 10.1007/s10620-012-2072-0
2. Caviglia R, Boskoski I, Cicala M. Maintenance treatment with infliximab for the management of Crohns disease in adults. Biologics: Targets & Therapy. 2009: 3 39-34. Review.
3. Guarino MP, Carotti S, Morini S, et al. Decreased number of activated macrophages in gallbladder muscle layer of cholesterol gallstone patients following ursodeoxycholic acid. Gut. 2008; 57(12): 1740-1741. doi: 10.1136/gut.2008.160333.
4. Ribolsi M, Perrone G, Caviglia R, et al. Intercellular space diameters of the oesophageal epithelium in NERD patients: head to head comparison between light and electron microscopy analysis. Dig Liver Dis. 2009; 41(1): 9-14. doi: 10.1016/j.dld.2008.07.318
5. Caviglia R, Boskoski I, Cicala M. Long-term treatment with infliximab in inflammatory bowel disease: safety and tolerability issues. Expert Opin Drug Saf. 2008; 7(5): 617-632. doi: doi: 10.1517/14740338.7.5.617
6. Caviglia R, Ribolsi M, Rizzi M, Emerenziani S, Annunziata ML, Cicala M. Maintenance of remission with infliximab in inflammatory bowel disease: efficacy and safety long-term follow-up. World J Gastroenterol. 2007; 13(39): 5238-5244. doi: 10.3748/wjg.v13.i39.5238.
7. Emerenziani S, Sifrim D, Habib FI, et al. Presence of gas in the refluxate enhances reflux perception in non-erosive patients with physiological acid exposure of the oesophagus. Gut. 2008; 57(4): 443-447.
8. Del Vescovo R, Sansoni I, Caviglia R, et al. Dynamic contrast enhanced magnetic resonance imaging of the terminal ileum: differentiation of activity of Crohns disease. Abdom Imaging. 2008; 33(4): 417-424. doi: 10.1007/s00261-007-9267-4
9. Emerenziani S, Cicala M, Zhang X, et al. Effect of oesophagitis on proximal extent of gastro-oesophageal reflux. Neurogastroenterol Motil. 2007; 19(6): 459-464. doi: 10.1111/j.1365-2982.2006.00868.x
10. Caviglia R, Ribolsi M, Gentile M, et al. Dilated intercellular spaces and acid reflux at the distal and proximal oesophagus in patients with non-erosive gastro-oesophageal reflux disease. Aliment Pharmacol Ther. 2007; 25(5): 629-636. doi: 10.1111/j.1365-2036.2006.03237.x
11. Emerenziani S, Habib FI, Ribolsi M, et al. Effect of hiatal hernia on proximal oesophageal acid clearance in gastro-oesophageal reflux disease patients. Aliment Pharmacol Ther. 2006; 23(6): 751-757. doi: 10.1111/j.1365-2036.2006.02816.x
12. Merola E, Mattioli E, Minimo C, et al. Immunohistochemical evaluation of pRb2/p130, VEGF, EZH2, p53, p16, p21waf-1, p27,and PCNA in Barretts esophagus. J Cell Physiol. 2006; 207(2): 512-519. doi: 10.1002/jcp.20590
13. Vespasiani Gentilucci U, Caviglia R, Picardi A, et al. Infliximab reverses growth hormone resistance associated with inflammatory bowel disease. Aliment Pharmacol Ther. 2005; 21(9): 1063-1071. doi: 10.1111/j.1365-2036.2005.02449.x
14. Caviglia R, Ribolsi M, Maggiano N, et al. Dilated intercellular spaces of esophageal epithelium in non-erosive reflux disease patients with physiological esophageal acid exposure. Am J Gastroenterol. 2005; 100(3): 543-548. doi: 10.1111/j.1572-0241.2005.40978.x
15. Cicala M, Gabbrielli A, Emerenziani S, et al. Effect of endoscopic augmentation of the lower oesophageal sphincter (Gatekeeper reflux repair system) on intra-oesophageal dynamic characteristics of acid reflux. Gut. 2005; 54(2): 183-186.
16. Cicala M, Emerenziani S, Caviglia R, et al. Intra-oesophageal distribution and perception of acid reflux in patients with non-erosive gastro oesophageal reflux disease. Aliment Pharmacol Ther. 2003 15; 18(6): 605-613. doi: 10.1046/j.1365-2036.2003.01702.x
17. Annovazzi A, Biancone L, Caviglia R, et al. 99mTc-interleukin-2 and (99m)Tc-HMPAO granulocyte scintigraphy in patients with inactive Crohns disease. Eur J Nucl Med Mol Imaging. 2003; 30(3): 374-382. doi: 10.1007/s00259-002-1069-x
18. Fracasso P, Caviglia R, Grassi A, et al. Turcot syndrome: case report and nosological aspects. J Exp Clin Cancer Res. 1997; 16(4): 433-435.
19. Caviglia R, Di Castro A, Cannaviello C, Lippi B. Fistulizing Crohn’s disease complicated by hidden retroperitoneal abscess: a case report and review of the literature. Gastro Open J. 2014; 1(1): 3-6.

Alexandros Charalabopoulos, MD, PhD, FRCS

Consultant Upper GI & General Surgeon
Mid Essex Hospital Services NHS Trust
Broomfield Hospital
Broomfield, Chelmsford
Essex CM1 7ET, UK

BiographyResearch InterestScientific ActivitiesPublications
Consultant Upper GI & General Surgeon with an interest in Minimally Invasive Oesophagogastric Cancer Surgery.

Broomfield Hospital, Mid Essex Hospital Services NHS Trust


Permanent full time post from December 2013

As an Upper GI & General Surgery Consultant with a major interest in oesophagogastric cancer resection surgery, I perform all the operations in the spectrum of upper gastrointestinal surgery and mainly in the field of upper GI cancer surgery and its minimally invasive treatment. Broomfield Hospital is a high volume and the regional oesophagogastric cancer center in which more than 100 oesophagogastric resections per year are performed. I perform all types of oesophagectomies with the majority being laparoscopic assisted Ivor-Lewis oesophagogastrectomies and all the types of gastrectomies. Most of the elective operations I perform are laparoscopic. I perform upper GI and general surgical operations like laparoscopic incisional and inguinal (TEP and TAPP) hernia repair, laparoscopic cholecystectomy and CBD exploration, laparoscopic fundoplication, and laparoscopic Heller’s myotomy. I perform robotic upper GI surgery and especially robotic assisted Heller’s myotomy, robotic gastric resections and robotic gastric pacing. I also have a special interest in the treatment of gastroparesis and I am one of the two surgeons in the region who specializes in gastric pacing. I do general surgical on calls in a 1 in 8 rota. I perform upper GI diagnostic and therapeutic endoscopy and do upper GI and general surgical clinics. I am also a key member of the upper GI cancer MDT meetings.
As an Upper GI Surgeon I have been extensively trained in all types of oesophagectomies (Ivor-Lewis, McKeown, transhiatal, thoracoabdominal, minimal invasive), gastrectomies with extensive lymph node dissections (D1, D2 and even D3), bariatric surgery (gastric bypass, sleeve gastrectomy, gastric band, intragastric balloon) and laparoscopic benign upper GI disease. I have received expert training in Upper GI surgery from internationally renowned units. Specifically, cancer resections through fellowships from Broomfield Hospital in Chelmsford, National Cancer Centre Hospital in Tokyo, St Thomas’ Hospital in London and upper GI advanced laparoscopic procedures including bariatric surgery from St Thomas’ and St George’s Hospitals in London. I have also had advanced training in general surgery (mainly HPB, colorectal, endocrine, vascular) and was awarded an MSc and a PhD for my research in experimental acute pancreatitis and gastrointestinal carcinogenesis respectively. So far I have participated in about 3000 operations, the great majority of which is in the field of Upper GI surgery, having performed more than 1800 of those.

His research interests include: oesophagogastric cancer resection surgery, treatment of gastroparesis

INVITED SPEAKER

1. Bariatric surgery. Operations and pitfalls. Chairman: Mr A Botha. FY2/CT/SHO Surgical Education Day. Guys and St Thomas Education Centre, London, UK. 07 Feb 2013
2. Complications of bariatric surgery. Round table. Chairman: Dr S Chong. South Thames Gut Club Meeting. Post Grad Lecture Theatre, St Helier Hospital. London, UK. 24 Nov 2011.
3. Round Table: The role of adhesion molecules in cancer. New useful tools. Topic: Cadherins. 15th Scientific Congress of Greek Medical School Students & 3rd International Forum of Medical Students and Young Doctors of Greece. Thessaloniki, Greece, 8-10 May 2009.
4. Surgical anatomy of the liver and types of hepatectomies. Higher Surgical Training Meeting of University of Athens. Attikon University Hospital, Athens, Greece. June 2009.

5. Respiratory failure and its prevention in the surgical patient. Higher Surgical Training Meeting of University of Athens. Attikon University Hospital, Athens, Greece. Feb 2008.
6. Oesophageal resection with colonic interposition. Round table. Chairman: Prof Liakakos. 1st Joined Meeting of the Travelling Surgical Society of Great Britain and Northern Ireland and the Third Academic Department of Surgery of the University of Athens. Attikon University Hospital, Athens, Greece. Sept 2008.
7. Spontaneous kidney rupture. A&E East Anglia Meeting. Peterborough Hospital, Peterborough, UK. April 2006.
8. Surgical pathology of liver and spleen. Basic Surgical Training Meeting. Post graduate center, Peterborough Hospital, Peterborough, UK. July 2005.

8. Surgical pathology of liver and spleen. Basic Surgical Training Meeting. Post graduate center, Peterborough Hospital, Peterborough, UK. July 2005.
9. Sore throat. ENT East Anglia Meeting. Peterborough Hospital, Peterborough, UK. Oct 2005.
10. Sensorineural hearing loss. ENT East Anglia Meeting. Peterborough Hospital, Peterborough, UK. Jan 2006.
11. Management of surgical infection. Basic Surgical Training Meeting. Post graduate center, Peterborough Hospital, Peterborough, UK. July 2005.


MEMBER OF COMMITTEES/SOCIETIES

Member of AUGIS - Association of Upper Gastrointestinal Surgeons of Great Britain & Ireland
Member of BOMMS - British Obesity & Metabolic Surgery Society
Member and Fellow of RCSEng - The Royal College of Surgeons of England
Member of EA-HPB-A - European-African Hepato-Pancreato-Biliary Association
Member of HPB-HS - The Hepato-Pancreato-Biliary Hellenic Society

PUBLICATIONS IN PEER REVIEWED INTERNATIONAL JOURNALS IN THE LAST 5 YEARS INCLUDE:

1. Charalabopoulos A, Golias C. E-cadherin expression in Barretts esophagus and esophageal carcinoma. Esophagus. 2014.
2. Charalabopoulos A, Lambropoulou M, Papalois A, Papachristou F, Simopoulos C, Tsaroucha A. Does apigenin exert a prophylactic effect in acute pancreatitis An experimental study evaluating pancreatic TNF- expression. J Surg Res. 2013.
3. Charalabopoulos A, Botha AJ. Laparoscopic cholecystectomy in the presence of lumboperitoneal shunt. Case Rep Surg. 2013; doi: 10.1155/2013/929082.
4. Machairas A, Tsapralis D, Samaras VD, et al. Basaloid squamous cell carcinoma of the rectum. A rare entity. J Med Cases. 2013; 4(8): 535-539.
5. Machairas A, Petropoulos K, Machairas N, Charalabopoulos A, Misiakos EP. Image of the month. Choledochocele. Arch Surg. 2011; 146(10): 1213-1214. doi: 10.1001/archsurg.2011.263-a.
6. Golias C, Batistatou A, Bablekos G, et al. Physiology and pathophysiology of selectins, integrins, and IgSF cell adhesion molecules focusing on inflammation. A paradigm model on infectious endocarditis. Cell Commun Adhes. 2011; 18(3): 19-32. doi: 10.3109/15419061.2011.606381.
7. Misiakos EP, Siama E, Schizas D, et al. Massive Uterine Leiomyoma in a Patient with Friedreichs Ataxia: Is There a Possible Association. Case Report Med. 2011; 2011:648217. doi: 10.1155/2011/648217.
8. Charalabopoulos K, Makris G, Charalabopoulos A, Golias C, Athanasiou K. Public knowledge, beliefs and practices in Greece about cancer etiology and prevention. East Mediterr Health J. 2011; 17(5): 392-397.
9. Charalabopoulos K, Krivan S, Machairas N, Misiakos , Machairas. Endopancreatic bile duct cholangiocarcinoma in a patient with Peutz-Jeghers syndrome. HPB Surgery. 2011; 2011: 364570. doi: 10.1155/2011/364570.
10. Charalabopoulos , Macheras , Krivan S, Petropoulos K, Misiakos , Macheras A. Arteriovenous malformation of the pancreas. Case Reports Med. 2011; 2011: 612657.
11. Charalabopoulos A, Misiakos E, Macheras A. Colocutaneous fistula complicating sigmoid diverticulitis. Int J Surg Case Rep. 2011; 2: 68-70.
12. Batistatou A, Charalabopoulos A, Charalabopoulos K. Molecular basis of colorectal cancer. N Engl J Med. 2010; 362(13): 1246.
13. Tsapralis D, Charalabopoulos A, Karamitopoulou E, et al. Pancreatic intraductal papillary mucinous neoplasm with concomitant heterotopic pancreatic cystic neoplasia of the stomach: a case report and review of the literature. Diagn Pathol. 010; 5: 4. doi: 10.1186/1746-1596-5-4.
14. Charalampopoulos A, Charalabopoulos A, Batistatou A, et al. Parathormone and 1,25(OH)2D3 but not 25(OH)D3 serum levels, in an inverse correlation, reveal an association with advanced stages of colorectal cancer. Clin Exp Med. 2010; 10(1): 69-72. doi: 10.1007/s10238-009-0069-6.
15. Charalabopoulos A, Misiakos EP, Foukas P, et al. Localized peripancreatic plasma cell Castleman disease. Am J Surg. 2010; 199(5): 51-3. doi: 10.1016/j.amjsurg.2009.05.020.
16. Yiotakis I, Georgolios A, Charalabopoulos A, et al. Primary localized laryngeal amyloidosis presenting with hoarseness and dysphagia: a case report. J Med Case Reports. 2009; 3: 9049. doi: 10.4076/1752-1947-3-9049.
17. Charalabopoulos K, Kotsalos A, Batistatou A, et al. Serum and tissue selenium levels in gastric cancer patients and correlation with CEA. Anticancer Res. 2009; 29(8):3465-7.
18. Batistatou A, Charalabopoulos A, Charalabopoulos K. Molecular basis of metastasis. N Engl J Med. 2009; 360(16): 1679. doi: 10.1056/NEJMra0805239.
19. Charalampopoulos A, Macheras A, Charalabopoulos A, Fotiadis C, Charalabopoulos K. Iliopsoas bscesses: diagnostic, aetiologic and therapeutic approach in five patients with a literature review. Scand J Gastroenterol. 2009; 44(5): 594-599. doi: 10.1080/00365520902745054.
20. Rashid F, Charalabopoulos A, Iftikhar SY. A multicenter UK study on trainee involvement in clinical audit: is it an effective contribution to service quality improvement or a portfolio generating activity? Gastro Open J. 2015; 1(4): 129-132. doi: 10.17140/GOJ-1-122

Cristina Marfinati Hervoso, MD

Physician and Gastroenterologist /Endoscopist
CAM – Centro Analisi Monza (MB)
Via Martiri delle Foibe, 1
Monza Monza e della Brianza, Italy

BiographyResearch InterestScientific ActivitiesPublications

Graduated in Medicine and specialized in Gastroenterology and Digestive Endoscopy at UNIFESP, Sao Paulo, Brazil, from 1994 to 2004, subsequently having convalidated the medical titles by the Italian Ministry of Health, I started my carreer abroad working for some of the most considerable and efficient hospitals in Italy, including a one-year period of fellowship in ERCP in Policlinico Gemelli, Rome, with Prof. Costamagna. During all these years I have developed several skills in diagnostic and operative digestive endoscopy (from participation in the national colorectal cancer screening program to the perfomance of several operative procedures, including deployment of gastrointestinal stents, mucosectomies, ESD and dealing with emergency endoscopic procedures as for some examples) and had the possibility to cooperate with clinics specialized in gastrointestinal motor disorders, celiac disease and IBD, which broadened my horizons.

Her research interests include: Esophageal reflux disease, Esophageal motor disorders, Endoscopic procedures, New technologies in Endoscopic Imaging

TRAINING EVENTS, CONGRESS AND ABSTRACTS

2003

• UEGW Submission of the abstract Performance of the different models of needles for the diagnosis of pancreatic lesions solid allEUS Endoscopy 2003, 35 (Suppl II) A87, Madrid, Spain


2004

• Participation in the Theoretical and Practical Course of Diagnostic and Operative Endosonography: from theoretical foundations to advanced techniques, Turin, Italy
• Participation in the National Congress Course Pre-Congress of the Italian Association for Gastroenterology and Endoscopy of the Hospital Sector and the Italian Society of Gastroenterology: Lymphoma in Gastrointestinal Diseases. An unexpected risk, Turin, Italy;
• Participation in the X National Congress of Digestive Diseases Italian Federation of Digestive System Diseases, Turin, Italy;
• Participation in the Course Post-Congress of the Italian Society of Digestive Endoscopy: Colon Cancer: Genetics from the Palliative Care, Turin, Italy


2005

• Presentation of the abstract Focal Chronic Pancreatitis: Contribution of endoscopic ultrasound in the diagnosis of PAAF associated with pancreatic cancer at the XVII Brazilian Seminar of Digestive Endoscopy, Victoria - Espirito Santo, Brazil
• Submission of the abstract in DDW The Role of Endoscopic Ultrasound with Fine Needle Aspiration in the differencial diagnosis of focal chronic pancreatitis and pancreatic adenocarcinoma, astrointestinal Endoscopy, V.61, No. 5, AB270, Chicago, USA
• Participation in the Theoretical and Practical Course Endoscopic treatment of early and advanced cancers of the digestive tract, Turin, Italy


2006

• UEGW - Participation in the fourteenth United European Gastroenterology Week, Berlin, Germany and Submission of the Endoscopic Injection of Fibrin Glue with standard needle injection sclerosis is effective in the submucosa before resection mucosa. A Comparative Study with Double-needle Channel Gut, 55:5 (2006 Oct), A158-A158
• Participation in the Third Joint Workshop on therapeutic endoscopy MI-TO EUS 1st International IEC live course, Turin, Italy


2007

• American College of Gastroenterology 72nd Annual Scientific Meeting of the American College of Gatroenterology, Philadelphia, USA
• DDW Submission of abstracts A Prospective Study of Narrow Band Imaging versus comparison Chromoendoscopy with Indigo Carmine versus White Light Colonoscopy in the detection of Adenomatous Colonic Lesions andTreatment of acute malignant colorectal obstruction with colonic stents WallFlex: a prospective study, Gastrointestinal Endoscopy, 65:5 (Apr), AB351, Washington DC, USA
• Participation in the Course ERCP - Prosthetics for stenosis of the digestive system, Rozzano, Milan, Italy
• Participation in the Course The Gastrointestinal Stent, Rozzano, Milan, Italy
• Participation in the 5th International Meeting - The patient: A comprehensive Approach, Florence, Italy
• National Congress - Submission of abstracts Narrow-Band Imaging Endoscopy-as-a novel tool To assess mucosal angiogenesis in vivo in Inflammatory Bowel Disease: A preliminary report, A prospective study comparison of NBI versus Chromoendoscopy with Indigo Carmine versus White Light colonscopy in the detection of adenomatous colonic lesions and Wallflex colonic stents in the treatment of acute malignant colorectal obstruction Digestive and Liver Diseases Vol 39, Suppl. 2, Palermo, Italy


2008

• UEGW - Participation in the sixteenth United European Gastroentrology and Submission of the Week Hydroxy-propyl-methyl-cellulose is a safe and effective lifting agent for endoscopic mucosal resection of large colorectal polyps P1298, Vienna, Austria
• SIED-aigo-GETS Participation in the XI Training Course Triregionale, Stresa, Italy
National Congress - Presentation abstracts of fully equipped IT Knife-2 for the treatment of colorectal flat lesions larger than 3 cm: Preliminary results of the first application of this device in the lesions of the colon, Digestive and Liver Diseases Vol 40, suppl 1, S31;
• ORTC: A new endoscopic large clip for improved tissue compression and bleeding control, for digestive tract defects closure and transgastric endoscopic surgery Digestive and Liver Disease Vol 40, suppl 1, S74-75;
• Hydrxy-Propyl-Methyl-Cellulose is a safe and effective lifting agent for endosocpic mucosal resection of large colorectal polyps, Digestive and Liver Diseases, Vol 40, suppl1, S98, Rimini, Italy
• Participation in the Nexus 2008 - Update in Gastroenterology, Turin, Italy


2009

• Participation at the International Symposium on complications in GI-Endoscopy, Hannover, Germany and Submission of Perforation after polipectomy in chronic ischemic colitis: Are monopolar coagulation and diathermic loop with epinephrine infiltration safe?
• SIED - aigo-SIGE - FISMAD Participation in the XII Inter-regional Training Course, New Technologies: New Issues in Gastroenterology, Milan, Italy,
• Participation in the nineteenth UEGW United European Gastroenterology Week / WCOG, London, England
Participation in GERD: the weight of a disease, Milan, Italy


2010

• Participation in the Course Advanced Cardiac Life Support - ACLS course of 24 hours at the San Gerardo Hospital in Monza, Monza, Italy
• SIED - Aigo - Aigo GETS Participation in the Symposium SIED GETS Lombardy 2010 - Emergencies in Gastroenterology - The problem of the patient in oral anticoagulation and / or antiplatelet, Milan, Italy
• Participation in the Congress Esophagus and Stomach: An Often intriguing relationship, Parma, Italy
• Attendance at the event Great Masters of Gastroenterology, University of Bologna, Italy
• Participation in the Course Whats New in Gastroenterology and Digestive Endoscopy: From Theory to Practice, held at the Hospital Valduce Como, Milan and San Paolo Hospital in Milan, Italy


2011

• Masters Degree in Operative Endoscopy at the Catholic University of the Sacred Heart, Rome, Italy, and courses as follow:
• Biliopancreatic Endoscopy: Advanced Course Theoretical and Practical
• Endoscopic treatment of Digestive Bleeding: Advanced Course Theoretical and Practical
• Theoretical and Practical Advanced Course: Endoscopy biliopancreatic - COOK
• Theoretical and Practical Advanced Course: Techniques of polypectomy, EMR and ESD of (Endoscopic treatment of superficial neoplastic lesions of the digestive tract)
• Participation in the Full-Time Training Period as Advanced ERCP in Yellow, Policlinico Gemelli, Rome, Italy


2012

• SIED Participation in the Annual Meeting SIED Lazio, Advanced Course: Endoscopy in the identification and management of polyps and non-polypoid lesions of the colon-rectum, Congress SIED - Lazio, Rome, Italy
• Participation allEndoLiveRoma 2012 - Policlinico Gemelli, Rome, Italy
• National Congress Submission of abstracts Endoscopic interventions through the minor duodenal papilla in patients with pancreas normally fused,and Minor papilla sphincterotomy in patients with pancreas divisum, Digestive and Liver Diseases, Vol 44, suppl2 (March) S75, Naples, Italy
• DDW Submission of abstracts Endoscopic interventions through the minor papilla duodenal papilla in patients with pancreas normally fused and Minor papilla sphincterotomy in patients with pancreas divisum, Gastrointestinal Endoscopy, Vol 75, 4, suppl, (Apr) AB 311, San Diego , USA
• UEGW Submission of abstracts sphincterotomy of the minor papilla in patients with symptomatic pancreas divisum and pancreatic diseases and ERCP through the minor papilla in patients with pancreas normally fused. Indications, techniques and outcomes , Amsterdam, Netherlands
• Participation in EndoCampus - Residential Course Theoretical and Practical
• The endoscopic resection of superficial neoplastic lesions - From the study of the patient in the management of complications - Theory and Practice of animal models in EMR and ESD, Irpino Ariano, Avellino, Italy
• Participation in the Course New Frontiers and New Realities in Digestive Endoscopy Poliambulanza Foundation, Brescia, Italy


2013

• Participation allEndoLiveRoma 2013 - Policlinico Gemelli, Rome, Italy
• UEGW Participation in the twenty-first United European Gastroenterology Week, Berlin, Germany
• Participation in the IX Update in Gastroenterology - Specialists in children and adults in comparison as a speaker, Udine, Italy

2004

1. Thuler FP, Di Sena VO, Hervoso CM, Della Libera E, Ferrari AP. How many procedures are necessary to Achieve competency in colonoscopy? Arq Gastroenterol. 2004; 41 (4): 211-214. doi: http://dx.doi.org/10.1590/S0004-28032004000400002


2006

1. Spinelli P, Calarco G, Mancini A, Ni XG. Metal stents for malignant colorectal obstructionMinimally invasive therapy & allied technologies. Mitat official journal of the Society for Minimally Invasive Therapy. 2006; 15(6): 331-338. doi: 10.1080/13645700601038036


2007

1. Repici A, Conio M, De Angelis C, et al. Insulated-Tip Knife Endoscopic Mucosal Resection of Large Colorectal Polyps Unsuitable for Standard polypectomy. Am J Gastroenterol. 2007; 102(8): 1617-1623 doi: 10.1111/j.1572-0241.2007.01198.x
2. Repici A, Fregonese D, Costamagna G, et al. Ultraflex precision colonic stent placement for palliation of malignant colonic obstruction: a prospective multicenter study. Gastrointest Endosc. 2007; 66(5): 920-927. doi: http://dx.doi.org/10.1016/j.gie.2007.03.1042


2008

1. Repici A, Barbon V, De Angelis C, et al. Acute small-bowel perforation secondary to capsule endoscopy. Gastrointest Endosc. 2008; 67(1):180-183. doi: http://dx.doi.org/10.1016/j.gie.2007.05.044


2009

1. Arezzo A, Pagano N, Romeo F, et al. Hydroxy-propyl-methyl-cellulose is a safe and effective lifting agent for endoscopic mucosal resection of large colorectal polyps. Surg Endosc. 2009; 23(5): 1065-1069. doi: 10.1007/s00464-008-0133-4
2. De Caro G, Pagano N, Malesci A, et al. Endoclipping for gastric perforation secondary to second session of EMRC in locally residual early gastric cancer: A case report. Dig Liver Dis. 2009; 41(7): e32-e34. doi: 10.1016/j.dld.2008.04.004


2012

1. Doctor, I Have A Long Sausage-Shaped Lump In My Abdomen. Gastrointest Endosc. 2012; 75(5): 1100-1102. doi: 10.1016/j.gie.2012.01.018

Atilla Ertan, MD, FACP, AGAF, MACG

Director of the Ertan Digestive Disease Center and GI Center of Excellence, MHPB-Texas Medical Center
Professor at the University of Texas Medical School Gastroenterology & Hepatology Division
6400 Fannin, Suite 1400
Houston, Texas 77030, USA

BiographyResearch InterestScientific ActivitiesPublications

Dr. Ertan earned his medical degree in 1963 from the Ankara University Medical School in Turkey. Following completion of his fellowship in Gastroenterology at the Hospital of the University of Pennsylvania in 1971, he was professor of medicine at the Tulane University School of Medicine in New Orleans from 1980-90 where he was named Chief of the Gastroenterology Section from 1984-90 and Interim Chairman of Medicine Department from 1988-90. Then, he was Chief of the Gastroenterology Section at the Methodist Hospital/ Baylor College of Medicine (BCM) from 1990 to 2001. He is a Clinical Professor of Medicine at both BCM as well as Weill-Cornell Medical College. He is now professor at the University of Texas Health Science Center and Director of the Ertan Digestive Disease Center and Gastroenterology Center of Excellence at the Memorial Hermann Hospital-Texas Medical Center.

Dr. Ertan has a special interest and experience in the diagnosis and management of patients with inflammatory bowel diseases including Crohn’s disease, ulcerative colitis, various microscopic colitides; biliary/pancreatic benign and malignant disorders, Barrett’s esophagus with dysplasia and early cancer plus these patients’ need for various advanced GI endoscopic diagnostic/therapeutic modalities. More information from: www.atillaertan.com.

Dr. Ertan has achieved national and international recognition as an outstanding clinical scientist, educator, researcher, and administrator in the field of gastroenterology. He has published over 160 articles in peer review journals, book chapters, books, and has received numerous awards and honors. He received the Medicine Science Award of 1992 by the Turkish Science and Technology Research Assembly, 1996 Best Gastroenterologist Award by the Crohns and Colitis Foundation of America, and the 2003 Distinguished Clinician Award by the American Gastroenterology Association (AGA). In October 2003; he received the Master in Gastroenterology Award from the American College of Gastroenterology (ACG) and the Fellow by AGA in 2007. He has been named to the Top Doctors in Houston and in the U.S. since 1995.
Dr. Ertan has been active in various national and international gastroenterology societies. For many years he served on the AGAs Education Committee (1994-97), the International Liaison Committee (1999-03), the ACGs International Relations Committee (Chair, International GI Training Subcommittee, 1994-98) and the Educational Affairs Committee (Chair 1999-01). He currently serves on the Editorial Boards of five different medical journals.

SELECTED PUBLICATIONS

Articles (*Peer Reviewed): In Turkish. Summary in English:

1. Ertan A, Gokay E, Buharali S, et al. Multiple myeloma. The Journal of the Faculty of Medicine University of Ankara. 1966; 10: 330-346.
2. Ertan A. The diagnostic values of beta-glucuronidase activity of gastric juice in the cases with gastric carcinoma. The Journal of the Faculty of Medicine University of Ankara. 1967; 20: 552-570.
3. Ertan A. The chemotherapy in the malignant diseases of gastrointestinal system. The Journal of the Faculty of Medicine University of Ankara. 1968; 21: 1247-1265.
4. Ertan A, Ozkan K, Turkvan M. The significance of serum beta-glucuronidase activity in patients with liver diseases. The Journal of the Faculty of Medicine University of Ankara. 1970; 18: 110-124.
5. Gokok, HN, Ertan A. Surgical treatment in patients with ulcerative colitis. Blue Bulletin. 1970; 2: 117121.
6. Ertan A. The clinical significance of the endogenous release of cholecystokinin-pancreozymine (CCK). The Journal of the Faculty of Medicine University of Ankara. 1973; 16( Supp.72): 1-61,.
7. Ertan A, Paykoc Z, Aktan H. The clinical course and prognosis in patients with acute pancreatitis. The Journal of the Faculty of Medicine University of Ankara. 1974; 17: 248-260.
8. Ertan A, Brooks FP. Mechanism of pancreatic exocrine secretion. Bulletin of Turkish Medical Academy. 1974; 9: 29-31.
9. Ertan A, Kandilci U, Aktan H, Berk U. Pancreatic carcinoma. The Journal of the Faculty of Medicine University of Ankara. 1975; 28: 125-133.
10. Ertan A, Kandilci U, Aktan H, Paykoc Z. The clinical course and prognosis of ulcerative colitis. The Journal of the Faculty of Medicine University of Ankara. 1975 28: 651-660.
11. Paykoc Z, Mentes NK, Ertan A, et al. The social and economical aspects of gastroenterology Postgraduate education of gastroenterology in Turkey. The Journal of the Faculty of Medicine University of Ankara. 1976; 29(Suppl.349): 1-70.
12. Ertan A. Candidates of gastrointestinal hormones. Contemporary Medical Journal. 1976; 3: 656-662.
13. Ertan A. Neuro-endocrine aspects of gastrointestinal system. Contemporary Medical Journal. 1976; 3: 724-728.
14. Koker E, Ertan A. Recent concepts in the radiological examinations of upper gastrointestinal tract. Bulletin of GATA 1977; 19: 383-389.
15. Ertan A: Endoscopic retrograde cholangiopancreatography. Bulletin of GATA. 1977; 19: 359-369.
16. Ertan A, Kandilci U, Danisoglu V, et al. Chiba Percutaneous transhepatic cholangiography. Bulletin of GATA. 1977; 19: 445-456.
17. Ertan A. Diet in patients with peptic ulcer disease. Contemporary Medical Journal. 1978; 27: 1187-1189.

Tatiana Goretsky (Zagranichnaya), PhD

Assistant Professor
Division of Digestive Diseases and Nutrition
Department of Internal Medicine
University of Kentucky
Lexington, KY 40506, USA

BiographyResearch InterestScientific ActivitiesPublications

Dr. Goretsky received her MS degree from Lomonosov (Moscow State) University and Ph.D. from Russian Academy of Science. She worked as a postdoctoral researcher at the University of Chicago in and at Northwestern University. Currently she is working as a Assistant Professor in the Department of Internal Medicine, Division of Digestive Diseases and Nutrition of the University of Kentucky at Lexington. She has extensive experience in the biochemical analysis of both human and mouse intestinal crypt cell populations. She was studying a controversial role of nicotine in the origin and progression of ulcerative colitis and Chrons disease. She has interest in epigenetic regulation of β-catenin signaling.
Inflammation induced intestinal stem cells activation. β-catenin signaling and post-translation modifications. Origin and progression of the inflammatory bowel disease.

Her research interests include: Interrogate the role of β-Catenins post translation modifications in transcriptional activation of intestinal epithelial stem cells.

She is working to evaluate a role of TNF-induced PI3K (p85α) signaling in nuclear translocation of β-catenin in colitis and colon cancer.

1. Goretsky T, Dirisina R, Managlia E, Lee G, Katzman RB, Barrett TA. Mechanisms of TNF-induced crypt cell apoptosis in colitis. Am J of Path. 2012; 181(4): 1306-1315.
2. Dirisina R, Katzman RB, Goretsky T, et al. P53 and PUMA independently regulate apoptosis of intestinal epithelial cells in patients and mice with colitis. Gastroenterology. 2011; 141(3): 1036-1045. doi: 10.1053/j.gastro.2011.05.032.
3. Brown JB, Cheresh P, Goretsky T, et al. Epithelial phosphatidylinositol-3-kinase signaling is required for beta-catenin activation and host defense against Citrobacterrodentium infection. Infect Immun. 2011; 79(5): 1863-1872. doi: 10.1128/IAI.01025-10
4. Lee G, Goretsky T, Managlia E, et al. Phosphoinositide 3-kinase signaling mediates β-catenin activation in intestinal epithelial stem and progenitor cells in colitis. Gastroenterology. 2010; 139(3): 869-81, 881. e1-e9. doi: 10.1053/j.gastro.2010.05.037.
5. Tang Y, Clayburgh DR, Goretsky T, et al. Epithelial NF-kappaB enhances transmucosal fluid movement by altering tight junction protein composition after T cell activation. Am J Pathol. 2010; 176(1): 158-167. doi: 10.2353/ajpath.2010.090548.
6. Brown JB, Lee G, Goretsky T, et al. Mesalamine inhibits epithelial beta-catenin activation in chronic ulcerative colitis. Gastroenterology. 2010; 138(2): 595-605, 605.e1-605.e3. doi: 10.1053/j.gastro.2009.10.038.


ADDITIONAL PUBLICATIONS (IN CHRONOLOGICAL ORDER)

1. Birukova AA, Zagranichnaya T, Alekseeva E, Bokoch GM, Birukov KG. Epac/Rap and PKA are novel mechanisms of ANP-induced Rac-mediated pulmonary endothelial barrier protection. J Cell Physiol. 2008; 215(3): 715-724.
2. Birukova AA, Zagranichnaya T, Fu P, et al. Prostaglandins PGE(2) and PGI(2) promote endothelial barrier enhancement via PKA- and Epac1/Rap1-dependent Rac activation. Exp Cell Res. 2007; 313(11): 2504-2520. doi: 10.1016/j.yexcr.2007.03.036
3. Zagranichnaya T, Wu X, Villereal ML. Endogenous TRPC1, TRPC3, and TRPC7 proteins combine to form native store-operated channels in HEK-293 cells. J Biol Chem. 2005; 280(33): 29559-29569.
4. Zagranichnaya T, Wu X, Danos A, Villereal ML. Gene expression profiles in HEK-293 cells with low or high store-operated calcium entry: can regulatory as well as regulated genes be identified? Physiol Genomics. 2005; 21(1): 14-33.
5. Villereal ML, Wu X, Zagranichnaya TK. A TRPC1/TRPC3-mediated increase in store-operated calcium entry is required for differentiation of H19-7 hippocampal cells. Faseb Journal. 2005; 19(4): A677-A677 Part 1 Suppl. S
6. Wu X, Zagranichnaya T, Gurda GT, Eves EM, Villereal ML. A TRPC1/TRPC3-mediated Increase in Store-operated Calcium Entry Is Required for Differentiation of H19-7 Hippocampal Neuronal Cells. J Biol Chem. 2004; 279: 43392 – 43402.
7. Babnigg G, Zagranichnaya T, Wu X, Villereal ML. Differential Tyrosine Phosphorylation of Plasma Membrane Ca2+-ATPase and Regulation of calcium pump activity by Carbacol and Bradykinin. J Biol Chem. 2003; 278(17): 14872-14882.
8. Villereal M, Zagranichnaya T, Wu X. Role of store-operated Ca2+ channels in regulating gene expression. Faseb Journal. 2003; 17(4): A45-A45 Part 1 Suppl. S.
9. Wu X, Babnigg G, Zagranichnaya T, Villereal ML. The role of human transient receptor potential protein 4(Htrp4) in thapsigargin-, carbachol- and diacylglycerol-stimulated calcium entry in HEK-293 cells. J Biol Chem. 2002; 277(16): 13597-13608.
10. Kulaeva ON, Zagranichnaya TK, Brovko FA, et al. New family of cytokinin receptors from Cereales. FEBS Letters. 1998; 423(2): 239-242.
11. Brovko FA, Zagranichnaya TK. Two methods to remove phenolic compounds from a plant extract. Plant Physiology and Biochemistry. 1998; 36: 10-16.
12. Zagranichnaya TK, Brovko FA, Shepelyakovskaya AO, Boziev KhM, Lipkin VM. Monoclonal antibodies to a 70-kD cytokinin-binding protein from etiolated maize seedlings. Russ J Plant Physiol. 1997; 44: 1-5.
13. Zagranichnaya TK, Brovko FA, Lipkin VM, Karavaiko NN, Selivankina SYu, Kulaeva ON. Monoclonal antibodies against new cytokinin-binding protein 70 kD from etiolated maize coleoptiles. J Plant Physiology and Biochemistry. 1996; (200).
14. Brovko FA, Zagranichnaya TK, Boziev KhM, et al. Isolation and characterization of a cytokinin-binding protein from etiolated maize seedlings. Russ J Plant Physiol. 1996; 43: 467-479.

Mohamed M El Kalaawy, MBChB, MS, MD, MRCSEd

Honorary Senior Lecturer
Division of Surgery & Interventional Science
University College London
Gower St, London WC1E 6BT, UK

BiographyResearch InterestScientific ActivitiesPublications
EDUCATIONAL QUALIFICATIONS

• 1991 : MB ChB (Alexandria)
• 1997: MS Surgery (Alexandria)
• 2005: MD Surgery (London-Alexandria)
• (April 2007): MRCSEd


CURRENT APPOINTMENT

• Bariatric Surgeon, University College London Hospital NHS Trust. UK
• Honorary Senior Lecturer, Division of Surgery & Interventional Science. University College London. UK
• Consultant and Senior Lecturer of Surgery, University of Alexandria. Egypt


PREVIOUS APPOINTMENTS

• (May 06 - Jun 2008): Senior Clinical Fellow in Bariatric Surgery. UCL NHS Trust, Department of Bariatric surgery.
• (Sep 05 - May 2006): Honorary Senior Fellow in Bariatric Surgery. St. Georges Healthcare NHS Trust, Department of Upper GI Surgery. (Post - Doctoral Grant Sponsored by the Egyptian Ministry of Higher Education)
• (Jan 04 - Aug 05): Consultant surgeon & Lecture, Department Of Surgery. Medical Research Institute, Alexandria University, Egypt
• (Aug 01 - Dec 03): Assistant Lecturer, Department of Surgery. Medical Research Institute, Alexandria University, Egypt
• (July 99 - July 01): Research Fellow, General Surgery. Academic Department of Surgery, St. Georges Hospital Medical School, London University

His research interests includes: Gastrointestinal services, The UCLH centre for weight loss, metabolic and endocrine surgery, General surgery.

CLINICAL RESEARCH

• Master Degree Thesis: Alexandria University in August 1996-1998
Title: “The role of Tranexamic Acid on Some Local Wound Complications after Modified Radical Mastectomy for Breast Cancer’’
• MD (Doctorate Degree) Thesis: Joint project between London University and Alexandria University in October 1999- 2003
Title: “Cholelithiasis: Relationship to Acute Pancreatitis”
Research included Clinical and immunological laboratory work on Trypsinogen Actiavtion in Pancreatitis patients.
• He has contributed in supervising the following research projects:
‘’Fast Track Gall Bladder Surgery’’ MS Thesis
Thesis was accepted by Alexandria University in June 2005.
• Current Academic Research Projects:
He contributed in supervising the MD project entitled “Liver Transplantation in End Stage Liver Disease Due to Hepatitis C Virus”. Joint project between University of Alexandria, Egypt and University of Massachusetts, USA.

1. ElKalaawy M, Saad A, ElAkkary E, Mansour M. Delayed Primary Closure of Pilonidal Sinus Disease. JMRI. 2005; 26(2): 161-164.
2. ElKalaawy M, AbouDiba M, Dowidar N, Ramadan M, El-Rowainy M. Fast Track Surgery for Optimizing Standard Postoerative Surgical care. JMRI. 2005; 26(2): 137-142.
3. Yousseif A, Emmanuel J, ElKalaawy M, et al. Differential Effects of Laparoscopic Sleeve Gastrectomy and Laparoscopic Gastric Bypass on Appetite, Circulating Acyl-ghrelin, Peptide YY3-36 and Active GLP-1 Levels in Non-diabetic Humans. Obesity Surgery. 2014; 24(2): 241-252. doi: 10.1007/s11695-013-1066-0.
4. Manning S, Carter N, Elkalaawy M, et al. Age- and sex-specific effects on weight loss outcomes in a comparison of sleeve gastrectomy and Roux-en-Y gastric bypass: a retrospective cohort study. BMC Obesity. 2014; 1: 12. doi: 10.1186/2052-9538-1-12
5. Manning S, Pucci A, Elkalaawy M, et al. Early postoperative weight loss predicts maximal weight loss after sleeve gastrectomy and Roux-en-Y gastric bypass. Surgical Endoscopy. 2014.

Jinghong Chen, PhD

Assistant Professor
Division of Gastroenterology (Visceral Pain Center)
Department of Internal Medicine
University of Texas Medical Branch at Galveston
Galveston, TX 77555, USA

BiographyResearch InterestScientific ActivitiesPublications
EDUCATION

• 9/1995-9/1998: Ph.D. of Neuroscience specializing in neurophysiology Neurophysiology of Brain Research Institute in China Medical Univ
• 9/1988-7/1991: M.S. of Pharmacy specializing in Pharmacology Shenyang Pharmaceutical University, China
• 9/1981-7/1985: B.S. of Pharmacy specializing in pharmaceutics Pharmacy Department of Neimeng Medical University, China


PROFESSIONAL WORK HISTORY AND TEACHING EXPERIENCE:

• 1/2010-present: Assistant Professor, University of Texas Medical Branch, Department of Internal Medicine, in Galveston, Texas, Investigate for the molecular and cellular mechanism behind Gut-Brain axis activation, motility and behavioral changes; Central Neuromodulation of Gastrointestinal Pain Reflexes; inflammatory pain-related plasticity and gender differences
• 12/2006-1/2010: Research scientist in Pharmacology Research of Pharmacy at UT, M.D. Anderson Cancer Center for anticancer drugs pharmacology study
• 5/2002 -12/2006: Postdoctoral Fellow, Dept. of Anesthesiology & Pain Medicine at UT M.D. Anderson Cancer Center to study mechanism of neuropathic pain/ hyperalgesia and synaptic transmission using patch-clamp techniques, biochemical & behavioral methods
• 8/1998-4/2002: Postdoctoral Fellow, Beijing Institute of Pharmacology and Toxicology for Neuropharmacological pain research for visceral hyperalgesia and morphine tolerance8/1995-6/1991: Pharmacology group leader, Tianjin Amino Acid Therapeutic Co., China. Director for drug examination, research, develop new method
• 9/1988-7/1991: Teaching Assistant and Lecturer, Neimeng Medical College, China. • Teaching experience: Teaching college courses of pharmacology and pharmacological experiment, Neurophysiology (China Medical University), tutoring medical students

Her research interests include: Neurophysiology of visceral pain, Brain–Gastrointestinal Axis (Neuronal excitability, synaptic transmission and plasticity from inflammatory bowel disease); visceral hyperalgecia/pain and psychological stress, anxiety/ depression behavioral change; Gender differences or ion channels receptors in colon pain modulation.

MEMBERSHIP IN SCIENTIFIC SOCIETIES/PROFESSIONAL ORGANIZATIONS:

• Editorial Board member in Journal of Pain & Relief, JSM Gastroenterology and Hepatology
• Member of American Society of Neuroscience
• Member of American Society and Association for Study of Pain
• Member of Chinese Pharmacological Society
• The reviewer for the J Pain Res and BMC Medical Genomics


HONORS:

• Recipient of Servier Young Investigator Prize in Pharmacology awarded by the Institute de Researches Internationales Servier, France and Chinese Pharmacological Society, May 2002.
• Excellent English lecture award in the Chinese Young Pharmacologists Symposium. Chinese Pharmacological Society, Jan. 2002.
• Excellent paper award in the 4th East-West International Pain Conference. Apr. 2000.
• Excellent paper in Annual Academic Conference of Chinese Academy of Military Medical Science. Jan. 2001.
• Excellent PhD Dissertation, Oct. 2000.
• Excellent paper in the Annual Academic Conference of Chinese Academy of Military Medical Science. Jan. 1999
• Employee recognition award (MD Anderson Cancer Center), May 2008
• Editor’s review of Chinese Science Bulletin: A new evidence of pain specific theory from Dr. Chen (1998, 43: 1467~1471) for her important publishing in the journal.

PUBLISHED: https://www.researchgate.net/profile/JingHong_Chen/publications
PEER-REVIEWED JOURNALS:

1. Yuan S, Shi Y, Chen J, et al. Gp120 in the pathogenesis of human HIV-associated pain. Annals of Neurology. 2014; doi: 10.1002/ana.24139
2. Winston J, Chen J, Shi X-Z, Sarna SK. Inflammation induced by mast cell deficiency rather than the loss of interstitial cells of Cajal causes smooth muscle dysfunction in W/Wv mice. Frontiers. 2014; 5:22.
3. Chen J, Winston J, Sarna SK. Neurological and cellular regulation of visceral hypersensitivity induced by chronic stress and colonic inflammation. Neuroscience. 2013; 248C: 469-478. doi: 10.1016/j.neuroscience.2013.06.024
4. Chen J, Gong ZH, Yan H, Qin BY. Neuroplastic alteration of TTX-resistant sodium channel with visceral pain and morphine-induced hyperalgesia. J Pain Research. 2012; 5: 491-502 doi: 10.2147/JPR.S27751
5. Choi K, Chen J, Mitra S, Sarna SK. Impaired integrity of DNA after recovery from inflammation causes persistent dysfunction of colonic smooth muscle. Gastroenterology. 2011; 141(4): 1293-301. doi: 10.1053/j.gastro.2011.06.074
6. Chen J, Winston J, Sarna SK. Ulcerative Colitis-Like DSS Inflammation Primes Afferent Nerves to Exaggerate Visceral Hypersensitivity to Colorectal Distension by Chronic Stress. Gastroenterology. 2011; 140(5): S-535
7. Smith JA, Chen J, Gaikwad A, et al. Evaluation of letrozole for the prevention and inhibition of tumor growth in human cervical cancer xenograft mouse models. Cancer Prevention Research. 2011; 4(10): Suppl1: B78
8. Mach CM, Chen JH, Mosley SA, Kurzrock R, Smith JA. Evaluation of Liposomal curcumin cytochrome P450 metabolism. Anticancer Research. 2010; 3: 126-132.
9. Weng HR, Chen JH, Pan ZZ. Glial glutamate transporter 1 regulates the spatial and temporal coding of glutamatergic synaptic transmission in spinal lamina II neurons. Neuroscience. 2007; 149(4): 898-907. doi: 10.1016/j.neuroscience.2007.07.063
10. Chen JH, Saucier JM, Gaikwad A, Brown J, Smith JA. Evaluation of the impact of treatment delays and dose reductions in human ovarian cancer xenograft models. Reproductive Sciences. 2008; Suppl 15: Abs 860
11. Weng HR, Chen JH, Dougherty PM. Inhibition of glutamate uptake in the spinal cord induces mechanical hyperalgesia and increased responses of spinal dorsal horn neurons to peripheral afferent stimulation. Neuroscience. 2006; 138(4): 1351-1360. doi: 10.1016/j.neuroscience.2005.11.061
12. Cata JP, Weng HR, Chen JH, Dougherty PM. Altered discharges of spinal wide dynamic range neurons and down-regulation of glutamate transporter expression in rats with paclitaxel-induced hyperalgesia. Neuroscience. 2006; 138(1): 329-38. doi: 10.1016/j.neuroscience.2005.11.009
13. Chen JH, Liu Y, Gong ZH. Colitis pain model induced by colonic submucosal injection of bee venom in rats. Chin J Pharmacol & Toxicol. 2006; 20(1): 71-75.
14. Weng HR, Cata JP, Chen JH, Shaw AD, Dougherty PM. Spinal glial glutamate transporters downregulate in rats with taxol-induced hyperalgesia. Neurosci Lett. 2005; 386(1): 18-22. doi: 10.1016/j.neulet.2005.05.049
15. Chen JH, Weng HR, Dougherty PM. Sensitization of dorsal root reflexes in vitro and hyperalgesia in neonatal rats produced by capsaicin. Neuroscience. 2004; 126(3): 743- IF:2.88 doi: 10.1016/j.neuroscience.2004.04.021
16. Kong Q, Chen JH, Gong ZH. The effect on NG108-15 Ca+ concentration in morphine treatment of L-nitryl arginine methoester. Dizocilpine and Nifedipin Chinese Journal of Pharmacology and Toxicology. 2004; 18(4): 264-268.
17. Chen JH, Liu Y, Gong ZH. A new model of rat spinal DRG and dorsal horn neuron culture. Bulletin of the Academy of Military Medical Sciences. 2004; 28: 395-396.
18. Chen JH, Liu Y, Gong ZH, Qin BY. Related neural mechanisms between visceral hyperalgesia and morphine tolerance. Chinese Journal of Pharmacology and Toxicology. 2002; 16(5): 321-327.
19. Chen JH, Teng GX. Dye-coupling and gap-junction after intraneuronal injection of neurobiotin on the visceral nociceptive neurons in somatosensory cortex of cat. Neuroscience Bulletin. 2000; 16(1): 1-4.
20. Chen JH, Teng GX. Electrophysiological and morphological properties of nociceptive neurons. Chinese Journal of Pain Medicine. 2000; 6: 53-55.
21. Jinghong Chen, Teng GX. Characterization of Morphologies and Intracellular Responses of Somatosensory Cerebral Cortex Neurons to Noxious Visceral Stimulation in Cat. Brain Research Gene expression patterns. 1999; 846(2): 243-256.
22. Chen JH, Teng G X. Intracellular electrophysiological characteristics of visceral nociceptive neurons in cortex SI area of cats. Acta Physiologica Sinica. 1999; 51(1): 31-37. 23. Chen JH, Teng GX. Electrophysiological and morphological characteristics of visceral nociceptive neurons in cortex SII area of cat. Acta Physiologica Sinica. 1999; 51(4): 344-349.
24. Chen JH, Teng GX. Comparison of the membrane electrophysiological characteristics of the visceronociceptive and nor-nociceptive neurons in cortical SI area. Chinese science bulletin. 1998; 43(14): 1467-1471.
25. Chen JH and Teng GX. Sensation and conduction of visceral pain in central nervous system. Progress of Anatomical Sciences. 1998; 4(2): 119-126.
26. Chen JH, Teng G X. Membrane properties of the visceral nociceptive neurons in cortex SI area of cat. Acta Biophysica Sinica. 1998; 14(2): 282-288.
27. Chen JH, Liu CM, Wang QZ. The studies on the analgesic effect of the scorpion analgesic peptide(SAP). Chinese Journal of Pain Medicine. 1997; 4: 211-222.
28. Chen JH, Zhang RD, Ma XL, et al. Analgesic effect of scorpion venom(Buthus Martensii Karsch Liaonin) on visceral pain in cats. J Chin Med Univ. 1997; 16(4): 10-14.
29. Wang Q Z and Chen JH. The separate, purification and analgesic action of the scorpion analgesic peptide. J Shenyang Pharm Univ. 1994; 11(4): 273-277.
30. Chen JH. The physiological and pharmacological research of part renin-angiotensin system. Chin Pharma Bulletin. 1990. 6(6): 344-347.

Pradeep K. Dudeja, PhD

Professor of Physiology & Director of Research
Division of Gastroenterology & Hepatology, Dept. of Medicine, UIC
Senior Research Career Scientist, Jesse Brown VAMC
Medical Research Service (600/151)
820 South Damen Avenue
Chicago, IL 60612, USA

BiographyResearch InterestScientific ActivitiesPublications
EDUCATION

Postgraduate Training:
Ph.D. Biochemistry

• 1978-1983 Postgraduate Institute of Medical Education and Research, Chandigarh (India)
• 1975-1978 M.S. Biochemistry, G.B. Pant University of Agriculture &Technology, Nainital (India)


Postdoctoral Training:

• 1983-1988 Research Associate, Department of (GI Physiol./Biochem.) Medicine, Section of Gastroenterology, Univ. of Chicago, Chicago, IL


ACADEMIC APPOINTMENTS

University Appointments

• Director of Research, Section of Digestive Diseases & Nutrition, 2010-present
• Director, Intestinal Transport Group, UIC & JBVAMC 2010-present
• Professor of Physiology in Medicine (tenured), 2002-present
• Digestive and Liver Diseases, University of Illinois at Chicago, Chicago, IL • Associate Professor of Physiology in Medicine, 1996-2002
• Digestive and Liver Diseases, University of Illinois at Chicago, Chicago, IL • Assistant Professor of Physiology in Medicine, 1991-1996
• Digestive and Liver Diseases, University of Illinois at Chicago, Chicago, IL • Assistant Professor (Research), Department of Medicine, 1988-1991
• Gastroenterology Division, Michael Reese Hospital & The University of Chicago, Pritzker, School of Medicine, Chicago, IL
• Research Associate, Gastroenterology, Michael Reese 1983-1988
• Hospital & Medical Center, Univ. of Chicago, Chicago, IL
• Tutor, Department of Biochemistry, Postgraduate 1981-1983
• Institute of Medical Education and Research, Chandigarh, India

Dr. Dudejas’ research group primarily focuses on the investigations of the molecular mechanisms of NaCl and short chain fatty acid absorption in the human intestine in health and disease. The long-term goal is to understand the cellular and molecular mechanisms underlying Pathophysiology of diarrhea associated with inflammatory bowel diseases or with bacterial infections and to develop strategies and tools for better treatment of diarrheal disorders. The approaches utilized include purified plasma membranes prepared from organ donor intestines, cell culture models and molecular biology techniques to provide an integrated in-vitro and in-vivo investigational model to examine the ion transport processes. Some specific projects include understanding mechanisms of modulation of sodium-hydrogen exchangers and chloride-bicarbonate exchangers in response to infection by an important food borne pathogen Enteropathogenic E. coli. Another project involves investigating the role of probiotics (lactobacillus species) in enhancing salt and water absorption in the mammalian intestine and mechanisms underlying these beneficial effects of probiotics. Other studies focus on understanding the role of monocarboxylate transporters in human colonic short chain fatty acid absorption. Since short chain fatty acids e.g butyrate and propionate play important roles as antineoplastic and anti-inflammatory agents as well as being the preferred nutrients for colonocytes, these ongoing studies have great significance in maintenance of epithelial integrity and disease prevention in colon. The hallmark of these studies is the direct investigation of the human intestine ion transport utilizing organ donors. These studies provide great training opportunities in the area of epithelial ion and nutrient absorption, host-microbe interactions, and approaches utilizing cell culture and animal models as well as the use of cutting edge molecular and imaging technologies.
Recently our group has also initiated studies to identify novel aspects related to gut microbiome in pathophysiological basis of inflammatory bowel diseases and to identify nanomedicine based therapeutic approaches to treat the diarrhea associated with IBD. We also have strong interest in defining the mechanisms of differentiation of intestinal stem cells into intestinal endocrine L cells as it relates to the direct effect of dietary fiber derived short chain fatty acids, which have potential in treatment of diabetes and metabolic syndrome.
Dr. Dudeja proposes to continue to work more in the direction of finding novel therapeutics for diarrheal diseases and take my work into translational arena. In addition, the role of stem cell-derived L- cells in metabolic syndrome and the utilization of nanomedicine based therapeutic approaches for diarrheal diseases and IBD are more exciting to pursue in the coming years.

SCIENTIFIC SOCIETIES (Memberships):

• American Physiological Society
• American Gastroenterological Association
• New York Academy of Sciences, New York


Role on Professional Societies:

• Member, Awards Committee, American Physiological Society, 1/1/02-12/31/04
• Member, Gastrointestinal Research Committee, American Gastroenterology Association, • Bethesda, MD, May 2000- May 2003.
• Chair, American Gastroenterological Association (AGA), Sponsored Research Symposia • Awards Committee of the GI Research Committee, (May 2002 – May 2003) Bethesda, MD.
• Member, American Gastroenterological Association, Abstract Selection Committee for • “Epithelial Transport” and “Signal Transduction” Subgroups December-2002
• Chair, Abstract Selection Committee for American Gastroenterological Association, • “Epithelial Transport” and “Signal Transduction” Subgroups December-2003
• Member: Steering Committee, American Physiological Society, GI & Liver Section, July 2011
• Chair, Nominating Committee for the Election of President of American Physiological Society, • GI & Liver Section, 2011
• Chair: Awards Committee, American Physiological Society, GI & Liver Section, July 2012- 2015
• Chair: AGA Abstract Review Committee for “Epithelial Junctions, Barrier Function & Wound • Repair” December 2013

MEMBERSHIP IN COMMITTEES/ADMINISTRATIVE RESPONSIBILITIES:

• Member, Campus Research Board, UIC, Clinical Sciences: Study Section: 7/1/00-6/30/04
• Chairman, Safety Sub-Committee, Jesse Brown VAMC, Chicago, IL., 1992- 1997
• Member, Safety Sub-Committee, Jesse Brown VAMC, Chicago, IL.2002-2006.
• Chairman, Safety Sub-Committee, Jesse Brown VAMC, Chicago, IL., 2006-2008
• Member, Board of Directors, West Side Institute for Science and Education, Chicago, IL., 1996- • 2008.
• Member: Space Allocation Subcommittee, Jesse Brown VAMC, Chicago, IL.2004-2008
• Member, Research and Development Committee, Jesse Brown VAMC, Chicago, IL., 1994- • Present.
• Member, Human Investigation Committee, Jesse Brown VAMC, Chicago, IL., 1992- 1994.
• Member, Animal Care & Use Committee, Jesse Brown VAMC, Chicago, IL., 1992- 1995, • 2001-2004
• Coordinator, Stephen L. Winter Memorial Library of the Section of Digestive and Liver • Diseases, Department of Medicine, Univ. of Illinois at Chicago, 1994-present.
• Coordinator, Research Conferences of the Section of Digestive and Liver Diseases, Department • of Medicine, Univ. of Illinois at Chicago, 1995-1996 and 2001-2002, 2003-2004.
• Chair, R & D Institutional Biosafety sub-committee, 4-2011-Present
• Member, R & D Advisory Panel (RDAP)-4-2011-Present
• Member, University of Illinois Senate, 2013-Present

ORIGINAL SCIENTIFIC PUBLICATIONS

Selected Publications (from a list of 195 publications in peer reviewed journals)

Most relevant to the current application:

1. Borthakur A, Bhattacharyya S, Alrefai WA, Tobacman JK, Ramaswamy K, Dudeja PK. Platlet activating factor-induced NF-kB activation and IL-8 production in intestinal epithelial cells are Bcl10 dependent. Inflamm. Bowel Diseases. 2010; 16(4): 593-603. doi: 10.1002/ibd.21092.
2. Bhattacharyya S, Dudeja PK, Tobacman JK. Tumor necrosis factor alpha-induced inflammation is increased but apoptosis is inhibited by common food additive carrageenan. J Biol Chem. 2010; 285(50): 39511-22. doi: 10.1074/jbc.M110.159681
3. Bhattacharyya S, Borthakur A, Tyagi S, et al. B-cell CLL/lymphoma 10 (BCL10) is required for NF-kappaB production by both canonical and noncanonical pathways and for NF-kappaB-inducing kinase (NIK) phosphorylation. J Biol Chem. 2010; 285(1): 522-30. doi: 10.1074/jbc.M109.050815
4. Bhattacharyya S, Dudeja PK, Tobacman J. ROS, Hsp27, and IKK? mediate dextran sodium sulfate (DSS) activation of IkBa, NfkB and IL-8. Inflammatory Bowel Diseases. 2009; 15(5): 673-683. doi: 10.1002/ibd.20821
5. Bhattacharyya S, Dudeja PK and Tobacman J. ROS, Hsp27, and IKK? mediate dextran sodium sulfate (DSS) activation of IkBa, NfkB and IL-8. Inflammatory Bowel Diseases. 2009; 15(5): 673-683. doi: 10.1002/ibd.20821


Additional recent publications of importance to the field (in chronological order):

6. Saksena S, Gill RK, Tyagi S, et al. Involvement of c-Src and PKC? in the Inhibition of Cl-/OH- Exchange Activity in Caco-2 Cells by Serotonin. J. Biol. Chem. 2005; 280 (12): 11859-11868. doi: 10.1074/jbc.M411553200
7. Gill RK, Saksena S, Tyagi S, et al. Serotonin inhibits Na+/H+ exchange activity via 5-HT4 Receptors and Activation of PKCa in Caco-2 Cells. Gastroenterology. 2005; 128: 962-974. doi: http://dx.doi.org/10.1053/j.gastro.2005.02.011
8. Alrefai WA, Wen X, Jiang W, et al. Molecular cloning and promoter analysis of downregulated in adenoma (DRA). Am J Physiol Gastrointest Liver Physiol. 2007; 293(5): G923-34. doi: 10.1152/ajpgi.00029.2007
9. Bhattacharyya S, Gill R, Chen ML, et al. Toll-like receptor 4 mediates induction of Bcl10-NFkappaB-IL-8 inflammatory pathway by Carrageenan in human intestinal epithelial cells. J. Biol. Chem. 2008; 283(16): 10550-10558. doi: 10.1074/jbc.M708833200.
10. Tobacman J, Bhattacharyya S, Borthakur A, Dudeja PK. The carrageenan diet: not recommended. Science. 2008; 321: 1040-1041. doi: 10.1126/science.321.5892.1040d
11. Walker NM, Simpson JE, Brazill JM, et al. Role of Down-regulated in adenoma anion exchanger in HCO3- secretion across murine duodenum. Gastroenterology. 2009; 136(3): 893-901. doi: 10.1053/j.gastro.2008.11.016
12. Walker NM, Simpson JE, Yen PF, et al. Down-regulated in adenoma Cl/HCO3 exchanger couples with Na/H exchanger 3 for NaCl absorption in murine small intestine. Gastroenterology. 2008; 135(5) 1645-1653. doi: 10.1053/j.gastro.2008.07.083
13. Gill RK, Borthakur A, Hodges K, et al. Mechanism(s) underlying inhibition of intestinal apical Cl/OH exchange following infection with enteropathogenic E. coli. J. Clin. Invest. 2007; 117: 428-437. doi: 10.1172/JCI29625
14. Tobacman J, Bhattacharyya S, Borthakur A, Dudeja PK. The carrageenan diet: not recommended. Science. 2008; 321: 1040-1041. doi: 10.1126/science.321.5892.1040d
15. Liu H, Singla A, Ao M, et al. Calcitonin receptor (CTR)-mediated CFTR activation in human intestinal epithelial cells (IECs). J Cell Mol Med. 2011; 20: 1582-4934. doi: 10.1111/j.1582-4934.2011.01264.x

Ajay Goel, PhD

Director, Gastrointestinal Cancer Research
Director, Cancer Genomics
Baylor Research Institute
Baylor University Medical Center
3500 Gaston Avenue, Suite H-250
Dallas, TX 75246, USA

BiographyResearch InterestScientific ActivitiesPublications

Dr. Goel, PhD is an Investigator (equiv. to Professor), Director of Epigenetics & Cancer Prevention, and Director, Cancer Genomics at Baylor Research Institute, Baylor University Medical Center in Dallas, TX. He is one of the top scientists in the world investigating botanical interventions.
Dr. Goel has spent 20 years researching cancer and has been the lead author or contributor to over 200 scientific articles published in peer reviewed international journals and several book chapters. He is currently researching the prevention of gastrointestinal cancers by developing disease biomarkers for the early detection of gastrointestinal cancers, and by using integrative and alternative approaches, including botanical products.
Dr. Goel is a member of the American Association for Cancer Research and the American Gastroenterology Association and is on the international editorial boards of Gastroenterology, Clinical Cancer Research, PLoS One, Digestive Diseases and Sciences, World Journal of Gastroenterology and World Journal of Gastrointestinal Oncology. Dr. Goel also performs peer reviewing activities for more than 100 international scientific journals, as well serves on various grant funding committees of the National Institutes of Health (NIH), Veterans Affairs Medical Centers, and other international funding agencies from Austria, UK, Czech Republic, Hungary, Australia and South Africa. His current research activities are actively funded by the National Cancer Institute and other federal and private research foundations.


Education and Training


• BS (Honors) (1985) Biophysics, Panjab University, Chandigarh, India
• MS. (Honors) (1988) Biophysics, Panjab University, Chandigarh, India
• PhD 1996; Biophysics, Panjab University, Chandigarh, India
• Post-doctoral fellowship: (1996-1998) Department of Biophysics and Physiology, University of Virginia, Charlottesville, VA
• Post-Doctoral fellowship: (1998-2001) Department of Medicine, University of California San Diego, La Jolla, CA

Gastrointestinal Cancer


His research interests include: The genetics and epigenetic basis of gastrointestinal cancers, Familial cancers and polyposis syndromes, Cancer epigenetics, including the role of DNA methylation, Non‐coding RNA and microRNAs and their role in cancer pathogenesis, Molecular pathology and diagnostics for gastrointestinal cancers, Prognostic and predictive biomarkers for colorectal cancer, Cancer disparities among different racial/ethnic populations, Personalized medicine for gastrointestinal cancers, Chemoprevention, using complementary and alternative approaches.

HONORS AND AWARDS


• (1988) Ministry of Education, Govt. of India, National Merit Scholarship during the course of M.S (Honors)
• (1990) Panjab University Gold medal for securing first position in the M.S. (Honors) in Biophysics
• (1991) Indian Council of Medical Research (ICMR) Junior Research Fellowship Award
• (1994) International Federation of Societies for Electron Microscopy (IFSEM) IFSEM-MSA-MAS scholarship
• (1999) American Association for Cancer Research - Pharmacia & Upjohn Young Investigator Award
• (1999) American Gastroenterological Association Poster of Distinction Award
• (2000) American Gastroenterological Association Poster of Distinction Award
• (2001) American Gastroenterological Association Poster of Distinction Award
• (2002) American Gastroenterological Association Distinguished Abstract Plenary Session Speaker
• (2002) American Gastroenterological Association Poster of Distinction Award
• (2002) Union of European Gastroenterology Federations Distinguished Researcher Award
• (2003) American Gastroenterological Association Poster of Distinction Award
• (2004) University of Hokkaido and Japanese Society of Pathology competitive travel grant to attend Second International Meeting on Polyomaviruses and Human disease
• (2009) American Gastroenterological Association Poster of Distinction Award
• (2011) American Gastroenterology Association Poster of Distinction Award
• (2012) Fellow, American Gastroenterological Association, USA
• (2012) American Association for Cancer Research, One of top five most cited article in 2010, in Cancer Biomarkers Epidemiology and Prevention
• (2014) Haydn Williams Visiting Professorship, Curtin University, Perth, Australia
• (2014) American Gastroenterological Association Poster of Distinction Award


MEMBERSHIP IN PROFESSIONAL ORGANIZATIONS


• (1998-present) American Gastroenterology Association (AGA)
• (1998-present) American Association for Cancer Research (AACR)
• (1994-1996) Microscopy Society of America (MSA)
• (1993 -present) Electron Microscopy Society of India (EMSI)
• (1989 -present) Association of Medical Physicists of India (AMPI)


OTHER PROFESSIONAL SERVICES AND ACTIVITIES


• (2005) Member, Gastrointestinal Oncology (GI-ONC) section of American Gastroenterological Association
• (2006) Member, Abstract Review Committee for Annual American Gastroenterological Association- Digestive Diseases Week meetings
• (2007) Member, Abstract Review Committee for Annual American Gastroenterological Association- Digestive Diseases Week meetings
• (2007) Chaired, Epigenetics and Colorectal Cancer Research Forum session at the AGA-DDW meeting, Washington, DC
• (2008) Member, Abstract Review Committee for Annual American Gastroenterological Association- Digestive Diseases Week meetings
• (2008) Chaired, Mechanisms of metastasis and Invasion of Gastrointestinal cancers Research Forum session at the AGADDW meeting, San Diego, CA
• (2009) Member, Abstract Review Committee for Annual American Gastroenterological Association- Digestive Diseases Week meetings
• (2009) Chaired, Epigenetics in colorectal cancer Oral symposium session at the Liver and Colorectal cancer: Molecular Biology and Clinical Research CIBERehd meeting, Barcelona, Spain
• (2009) Chaired, Epigenetics of GI Cancers Research Forum session at the AGA-DDW meeting, Chicago, IL
• (2009) Chaired Oncogenomics and Epigenomics in Human Cancers Research Symposium session at AGA-DDW meeting, Chicago, IL
• (2010) Member, Abstract Review Committee for Annual American Gastroenterological Association- Digestive Diseases Week meetings
• (2010) Chaired, Tumor microevironment and GI Cancers Research Forum session at the AGA-DDW meeting, New Orleans, LA
• 2011) Member, Abstract Review Committee for Annual American Gastroenterological Association- Digestive Diseases Week meetings
• (2011) Member, Research Policy Committee, American Gastroenterological Association (AGA), USA
• (2011) Expert member, World Health Organization (WHO) and International Agency for Research in Cancer (IARC) for monograph compilation on the role of polyomaviruses and cancer
• (2011) American Gastroenterological Association Research Policy Committee representative for the working group to review guidelines on colorectal cancer screening for African-Americans
• (2012 Member, Abstract Review Committee for Annual American Gastroenterological Association-Digestive Diseases meetings
• (2012) Member, Selection Committee for the Pancreas (PAN) Section Research Mentor Award Recipient of the American Gastroenterological Association DDW meeting 2012
• (2012) Member, Institutional Biosafety Committee, Department of Veterans Affairs, North Texas Health Care System, Dallas, TX
• (2012) Member, Subcommittee on Research Safety, Department of Veterans Affairs, North Texas Health Care System, Dallas, TX
• (2013) Member, American Gastroenterological Association (AGA) Student Research Fellowship Review Panel
• (2013) Chair, American Gastroenterological Association Institutes (AGAIs) abstract review committee for DDW 2014 meeting
• (2014) Member, Selection Committee for the AGAs Research Service Award panel
• (2014) Member, Selection Committee for the AGAs Research Mentor Awards
• (2014) Member, Program Committee on microRNAs and Noncoding RNAs section for the annual American Association for Cancer Research (AACR) meeting
• (2014) Chaired, Session on Non-Coding RNAs in Cancer at the Gene Silencing and Epigenetics, Genomics 2014 meeting, San Francisco, April 29-30,2014
• (2014) Chaired Epigenetics and Gastrointestinal Cancers Research Symposium session at AGA-DDW meeting, Chicago, IL

ORIGINAL PEER-REVIEWED RESEARCH ARTICLES/INVITED REVIEWS/EDITORIAL/BOOK CHAPTERS


1. Dhawan D, Goel A, Karkara K. Effects of carbontetrachloride and Liv-52 on the clearance rate of 131I-Rose Bengal in rat liver. AMPI Medical Physics Bulletin. 1991; 16(4): 27.
2. Dhawan D, Goel A, Singh K. Effects of carbontetrachloride on the clearance of 131I-Rose Bengal in rat liver. Medical Science Research. 1991; 19: 81.
3. Goel A, Dhawan D, Gautam CS. Influence of Liv-52 on carbontetrachloride induced hepatotoxicity: A biochemical study. Indian Journal of Pharmacology. 1991; 23: 182.
4. Goel A, Dhawan D. Preventive effects of Liv-52 on the activities of Cytochrome P-450 and NADPH-Dependent lipid peroxidation in liver of carbontetrachloride intoxicated rats. Medical Science Research. 1991; 19(4): 113.
5. Dhawan D, Singh B, Goel A, Chanan M, Sanyal SN. Effects of long term lead and lithium treatment on the uptake of radiolabeled nutrients in rat brain. Journal of Neurochemistry. 1992; 59(S): 530.
6. Dhawan D, Goel A, Gautam CS. Effects of zinc intake on liver enzymes in carbontetrachloride induced liver injury. Medical Science Research. 1992; 20: 55.
7. Singh B, Dhawan DK, Mangal PC, Goel A. The influence of lead toxicity on the biological half-life of 131I Rose Bengal in rat liver. Medical Science Research. 1992; 20(17): 623.
8. Goel A, Dhawan D, Kheruka S. Evaluation of zinc in the regulation of serum T3 and T4 levels and hepatic functions in carbontetrachloride intoxicated rats. Biological Trace Element Research. 1994; 41(1-2): 59.
9. Dhawan D, Goel A. (Hepatoprotective effects of Liv-52 and its indirect influence on the regulation of thyroid hormones in carbontetrachloride induced rat liver toxicity. Research In Experimental Medicine. 1994; 194(3): 203.
10. Dhawan D, Goel A. Protective role of zinc on rat liver function in long-term toxicity induced by carbon tetrachloride. Journal of Trace Elements In Experimental Medicine. 1994; 7: 1.
11. Goel A, Dhawan D, Sharma ML. Ultra structural studies of liver following zinc supplementation in carbontetrachloride intoxicated rats. Electron Microscopy. 1994; 3: 1233.
12. Dhawan DK, Goel A, Sharma ML. Hepatoprotective role of Liv-52 in toxic conditions of liver-an ultrastructural study. Electron Microscopy. 1994; 3: 1243.
13. Goel A. Biophysical and Biochemical studies on chlorpyrifos toxicity in liver-Evaluation of role of zinc. PhD Thesis, Panjab University, Chandigarh, India. 1996; 1-148.
14. Sharma ML, Goel A, Sharma RK. Biological specimen preparation for Electron Microscopy. In: Advances in Biological Sciences. Sobti RC. Roxana Publishers, India). 1995; 278-329.
15. Dhawan D, Goel A. Further evidence for zinc as a hepatoprotective agent in rat liver toxicity. Experimental Molecular Pathology. 1996; 63(2): 110-117.
16. Horikawa Y, Goel A, Somlyo AP, Somlyo AV. Mitochondrial calcium in the relaxed and tetanized myocardium. Biophysical Journal. 1998; 74: 1579.
17. Goel A, Chauhan D, Dhawan D. Protective effects of zinc in chlorpyrifos induced hepatotoxicity: A biochemical and trace elemental study. Biological Trace Element Research. 2000; 74(2): 171-183.
18. Chang DK, Ricciardiello L, Goel A, Chang CL, Boland CR. Steady- State regulation of the Human DNA Mismatch Repair system. Journal of Biological Chemistry. 2000; (24): 18424-184231.
19. Ricciardiello L, Chang DK, Laghi L, Goel A, Chang CL, Boland CR. Mad-1 is the exclusive JC virus strain present in the human colon, and its transcriptional control region has a deleted 98-base-pair sequence in colon cancer tissues. Journal of Virology. 2001; 74(4): 1996-2001.
20. Goel A, Boland CR, Chauhan DP. Specific inhibition of cyclooxygenase-2 expression by curcumin in HT-29 human colon cancer cells. Cancer Letters. 2001; 172(2): 111-118.
21. Goel A, Dhawan D. Zinc supplementation prevents liver injury in chlorpyrifos treated rats. Biological Trace Element Research. 2001; 82 (1-3): 185-200.
22. Gasche C, Chang CL, Rhees J, Goel A, Boland CR. Oxidative stress increases frameshift mutations in human colorectal cancer cells. Cancer Research. 2001; 61(20): 7444-7448.
23. Goel A, Arnold CN, Boland CR. Multistep progression of colorectal cancer in the setting of microsatellite instability: new details and novel insights. Gastroenterology. 2001; 121(6): 1497-1502.
24. Boland CR, Goel A. A rat virus visits the clinic: translating basic discoveries into clinical medicine in 21st century. Gut. 2003; 52(1): 8-9.
25. Goel A, Chang DK, Ricciardiello L, Gasche C, Boland CR. A novel mechanism for aspirin-mediated growth inhibition of human colon cancer cells. Clinical Cancer Research. 2003; 9(1): 383-390.
26. Heon LS, Chang DK, Goel A, et al. Microsatellite instability and suppressed DNA repair enzyme expression in rheumatoid arthritis. Journal of Immunology. 2003; 170 (4): 2214-2220.
27. Gasche C, Chang CL, Natarajan L, et al. Identification of Frameshift Intermediate Mutant Cells in Human Colorectal Cancer. Proceedings of National Academy of Sciences USA. 2003; 100(4): 1914-1919. doi: 10.1073/pnas.0437965100
28. Ricciardiello L, Goel A, Mantovani V, et al. Frequent loss of hMLH1 by promoter hypermethylation leads to microsatellite instability in adenomatous polyps of patients with a single firstdegree member affected by colon cancer. Cancer Research. 2003; 63(4): 787-792.
29. Goel A, Arnold CN, Niedzwiecki D, et al. Characterization of colon cancer by patterns of genomic instability. Cancer Research. 2003; 63: 1608-1614.
30. Tassone P, Tagliaferri P, Perricelli A, et al. BRCA1 expression modulates chemosensitivity of BRCA1-defective HCC1937 human breast cancer cells. British Journal of Cancer. 2003; 88(8): 1285-1291.
31. Chang DK, Goel A, Ricciardiello L, et al. Effect of H2O2 on Cell Cycle and Survival in DNA Mismatch RepairDeficient and Proficient Cell Lines. Cancer Letters. 2003; 195(2); 243-251. 32. Goel A, Arnold CN, Boland CR. The Role of hMLH1 Promoter Role of hMLH1 promoter hypermethylation in drug resistance to 5-fluorouracil in colorectal cancer. International Journal of Cancer. 2003; 106(1); 66-73.
33. Tassone P, Tagliaferri P, Goel A, et al. Zoledronic acid induces anti-proliferative and apoptotic effects in human pancreatic cancer cells in vitro. British Journal of Cancer. 2003; 88(12): 1971-1978.
34. Ricciardiello L, Baglioni M, Goel A, et al. Induction of chromosomal instability in colonic cells by the human polyomavirus JC virus. Cancer Research. 2003; 63(21): 7256-7262.
35. Boland CR, Goel A. The silence of the genes: Matching mismatch repair defects with tumors. Cancer. 2003; 98(10): 2091-2094.
36. Goel A, Arnold CN, Compton C, et al. Evaluation of microsatellite instability, hMLH1 expression and hMLH1 promoter hypermethylation in defining the phenotype of colorectal cancer. Cancer Biology and Therapy. 2004; 3(1): 73-78.
37. Carethers JM, Smith JE, Goel A, et al. Use of 5-Fluorouracil and survival in patients with microsatellite unstable colorectal cancer. Gastroenterology. 2004; 126(2): 394-401.
38. Goel A, Arnold CN, Niedzwiecki D, et al. Frequent inactivation of PTEN by promoter hypermethylation and its association with microsatellite instabilityhigh (MSI-H) in sporadic colorectal cancers. Cancer Research. 2004; 64(9): 3014-3021.
39. Goel A, Arnold CN, Tassone P, et al. Epigenetic inactivation of RUNX3 is an important event in TGF- mediated signaling in microsatellite unstable sporadic colon cancers-results from CALGB 9865. International Journal of Cancer. 2004; 112(5): 754-759.
40. Goel A, Arnold CN, Niedzwiecki D, et al. APC Promoter Hypermethylation Contributes Strongly to the Loss of APC Expression in Colorectal Cancers with Allelic Loss on 5q. Cancer Biology and Therapy. 2004; 3(10): 960-964.
41. Niv Y, Goel A, Boland CR. JC Virus and colorectal cancer-a possible trigger in the chromosomal instability pathway. Current Opinions in Gastroenterology. 2005; 21(1): 85-89.
42. Gasche C, Goel A, Natarajan L, Boland CR. Mesalazine improves replication fidelity in colorectal cells. Cancer Research. 2005; 65 (10): 3993-3997.
43. Ashktorab H, Smoot DT, Goel A, et al. Clinicopathological features and MSI in colorectal cancers from African Americans. International Journal of Cancer. 2005; 116(6): 914-919.
44. Boland CR, Luciani MG, Gasche C, Goel A. Recent advances in Basic Science: “Infection, Inflammation and GI Cancer”. Gut. 2005; 54(9): 1321-1331.
45. Goel A, Gasche C, Boland CR. Chemoprevention goes gourmet: different flavors of NO-aspirin. Molecular Interventions. 005; 5(4): 207-210.
46. Boland CR, Goel A. Somatic evolution of cancer cells. Seminars in Cancer Biology. 2005; 15(6): 436-450.
47. Goel A, Dani V, Dhawan DK. Protective effects of zinc on lipid peroxidation, antioxidant enzymes and hepatic histoarchitecture in chlorpyrifos induced toxicity. Chemico-Biological Interactions. 2005; 156: 131-140.
48. Arnold CN, Goel A, Boland CR. Molecular pathogenesis for colorectal cancer: Implications for molecular diagnosis. Cancer. 2005; 104(10): 2035-2047.
49. Goel A, Dani V, Dhawan DK. Chlorpyrifos induced alterations in the activities of carbohydrate metabolizing enzymes in rat liver. The role of zinc. Toxicology Letters. 2006; 163: 235-241.
50. Goel A, Dani V, Dhawan DK. Role of zinc in mitigating the toxic effects of organophosphate insecticide chlorpyrifos on hematological alterations and electron microscopic observations in rat blood. Biometals. 2006; 19(5): 483-492.
51. Goel A, Fuerst F, Hotchkiss E, Boland CR. Selenomethionine induces p53 mediated cell cycle arrest and apoptosis in human colon cancer cells. Cancer Biology and Therapy. 2006; 5(5): 529-535.
52. Shin SK, Shu LM, Goel A, et al. Oncogenic T-antigen of JC virus is frequently present in the human gastric cancers. Cancer. 2006; 107(3): 481-488.
53. Goel A, Shu LM, Nagasaka T, et al. Association of JC virus T-antigen expression with the methylator phenotype in sporadic colorectal cancers. Gastroenterology. 2006; 130(7): 1950-1961.
54. Nagasaka T, Goel A, Matsubara N, Tanaka N. Detection of fecal DNA methylation for colorectal neoplasia: Does it lead to an optimal screening test? . Acta Medica Okayama. 2006; 60 (5): 249-256.
55. Goel A, Nagasaka T, Arnold CN, et al. The CpG Island Methylator Phenotype and chromosomal instability are inversely correlated in sporadic colorectal cancer. Gastroenterology. 2007; 132(10): 127-138.
56. Goel A, Dani V, Dhawan DK. Zinc mediates normalization of hepatic drug metabolizing enzymes in chlorpyrifos-induced toxicity. Toxicology Letters. 2007; 169: 26-33.
57. Nishida N, Nagasaka T, Goel A, Kashiwagi K, Boland CR. High copy amplification of the Aurora-A gene is associated with chromosomal instability phenotype in human colorectal cancers. Cancer Biology and Therapy. 2007; 6(4): 525- 533.
58. Boland CR, Goel A, Ricciardiello L. Infection, inflammation and cancerthe future. Chapter 23, In: Intestinal Inflammation and Colorectal Cancer. (Falk symposium 158), Editors: C. Gasche, J.M. Herrerias, M. Gassull and E. Monterio. Springer, Dordrecht, Netherlands. 2007; 259-268.
59. Goel A, Ricciardiello L, Boland CR. DNA tumor viruses and colorectal cancer. Current Colorectal Cancer Reports. 2007; 3(2); 76-81. 60. Nishida N, Nishimura T, Nagasaka T, Ikai I, Goel A, Boland CR . Extensive methylation tightly associates with -catenin mutations in hepatocellular carcinoma: evidence for two distinct pathways of human hepatocarcinogenesis. Cancer Research. 2007; 67 (10): 4586-4594.
61. Dani V, Goel A, Vaiphei K Dhawan D. Chemopreventive potential of zinc in experimentally induced colon carcinogenesis. Toxicology Letters. 2007; 171(1-2): 10-18.
62. Shin SK, Nagasaka T, Goel A, et al. Epigenetic and genetic alterations in Netrin-1 receptors UNC5C and DCC in human colon cancer. Gastroenterology. 2007; 133(6): 1849-1857.
63. Goel A, Kunnumakkara AB Aggarwal BB . Curcumin as Curecumin: From kitchen to clinic. Biochemical Pharmacology. 2008; 75(4): 787-809.
64. Ogino S, Goel A. Molecular classification and correlates in colorectal cancer. Journal of Molecular Diagnostics. 2008; 10(1): 13-27. doi: 10.2353/jmoldx.2008.070082.
65. Tae JW, Li MS, Goel A, Boland CR. JC Virus T-antigen expression in sporadic adenomatous polyps of the colon. Cancer . 2008; 112(5): 1028- 1036. doi: 10.1002/cncr.23266.
66. Nishida N, Nishimura T, Goel A , Nagasaka T, Ikai I, Boland CR. Aberrant methylation of multiple tumor suppressor genes in aging liver, chronic hepatitis and hepatocellular carcinoma. Hepatology. 2008; 47(3): 908-918. 67. Nagasaka T, Goel A, Notohara K, et al. Matsubara NMethylation profile of O6- methylguanine-DNA methyltransferase gene in the large intestine: relationship of methylation pattern with tumor progression. International Journal of Cancer. 2008; 122(11): 2429-2436.
68. Goel A, Jhurani S, Aggarwal BB. Multi-targeted therapy with curcumin: How spicy is it? Molecular Nutrition and Food Research. 2008; 52(9): 1010- 1030. doi: 10.1002/mnfr.200700354.
69. Selgrad M, Malfertheiner P, Goel A, Fini L, Boland CR, Ricciardiello L. The role of viral and bacterial pathogens in gastrointestinal cancer. Journal of Cellular Physiology. 2008; 216(2): 378-388. doi: 10.1002/jcp.21427.
70. Goel A, Shin SK. CpG island methylator phenotype in colorectal cancer: the current perspective. Current Colorectal Cancer Reports. 2008; 4(2): 77-83. doi: 10.1158/0008-5472.CAN-12-4306.
71. Ahn KS, Sethi G, Sung B, Goel A, Ralhan R, Guggulsterone A. A farnesoid X receptor (FXR) antagonist, inhibits constitutive and inducible STAT3 activation through activation of a protein tyrosine Phosphatase SHP-1. Cancer Research. 2008; 68: 4406-4415. doi: 10.1158/0008-5472.CAN-07-6696.
72. Nagasaka T, Koi M, Goel A, et al. Mutations in both KRAS and BRAF may contribute to the methylator phenotype in colon cancer. Gastroenterology. 2008; 134(7): 1950-1960. doi: 10.1053/j.gastro.2008.02.094.
73. Brim H, Mokarram P, Goel A, et al. Impact of BRAF, MLH1 on the incidence of microsatellite instability high colorectal cancer in population based study. Molecular Cancer. 2008; 7(1): 68. doi: 10.1186/1476-4598-7-68.
74. Arnold CN, Nagasaka T, Goel A, et al. Molecular characteristics and predictors of survival in patients with malignant neuroendocrine tumors. International Journal of Cancer. 2008; 123(7): 1556-1564. doi: 10.1002/ijc.23690.
75. Haugen AC, Goel A, Yamada K, et al. Genetic instability caused by loss of MSH3 in human colorectal cancer; the molecular basis of MSI-L and EMAST tumors. Cancer Research. 2008; 68(20): 8465-8472. doi: 10.1158/0008-5472.CAN-08-0002.
76. Selgrad M, Koornstra JJ, Goel A, et al. JC virus infection in colorectal neoplasia developed after liver transplantation. Clinical Cancer Research. 2008; 14(20): 6717-6721.
77. Selgrad M, De Georgio R, Goel A, et al. JC Virus infects the enteric glia of patients with Chronic Idiopathic Intestinal Pseudo Obstruction. Gut. 2009; 58: 25-32. doi: 10.1136/gut.2008.152512.
78. Vilkin A, Niv Y, Goel A , et al. Microsatellite instability, MLH1 promoter methylation and BRAF mutation analysis in sporadic colorectal cancers of different ethnic groups in Israel. Cancer. 2009; 115(4): 760-769. doi: 10.1002/cncr.24019.
79. Boland CR, Komarova N, Goel A. Chromosomal instability and cancer: not just one CINgle mechanism. Gut. 2009; 58: 163-164. doi: 10.1136/gut.2008.160143.
80. Baba Y, Nosho K, Goel A, et al. AURKA (Aurora-A) overexpression is independently associated with chromosomal instability in colorectal cancer. Neoplasia. 2009; 11(5); 418-425.
81. Boland CR, Goel A . Polyp Biology. In: Colonoscopy: Principles and Practice, Editors: Waye JD, Rex DK and Williams CB. Wiley-Blackwell Publishing, UK. 2009; 349-357.
82. Boland CR, Shin SK, Goel A . Promoter methylation in the genesis of gastrointestinal cancer. Yonsei Medical Journal. 2009; 50(3): 309-321. doi: 10.3349/ymj.2009.50.3.309.
83. Giros A, Grzybowski A, Goel A, et al. Regulation of colorectal cancer cell apoptosis by the n-3 polyunsaturated fatty acids docosahexaenoic (DHA) and eicosapentaenoic (EPA) acid. Cancer Prevention Research. 2009; 2(8): 732-742. doi: 10.1158/1940-6207.CAPR-08-0197
84. Nagasaka T, Tanaka N, Goel A, et al. Analysis of fecal DNA methylation for detecting gastrointestinal neoplasia. Journal of National Cancer Institute. 2009; 101(18): 1244-1258.
85. Goel A, Mittal A, Evstatiev R, et al. In vivo effects of mesalazine and E. Coli Nissile 1917 on microsatellite instability and chromosomal instability in ulcerative colitis. Alimentary Pharmacology and Therapeutics. 2009; 30: 634-642.
86. Link A, Shin SK, Goel A, et al. JC Virus T-antigen mediates invasion and migration, and is frequently expressed in colorectal metastasis. PLoS One. 2009; 4(12): e8146: 1-12. doi: 10.1371/journal.pone.0008146.
87. Jung B, Gomez J, Goel A, et al. Activin signaling in microsatellite stable (MSS) colon cancers is disrupted by a combination of genetic and epigenetic mechanisms. PLoS One. 2009; 4(12): e8308: 1-8. doi: 10.1371/journal.pone.0008308.
88. Goel A, Boland CR . Recent insights into the pathogenesis of colorectal cancer. Current Opinions in Gastroenterology. 2010; 26(1): 47-52.
89. Boland CR, Ricciardiello L, Goel A. Involvement of the polyomavirus, JCV, in colorectal cancer. In: Viral Oncology: Basic to clinical perspectives. Editors: Jeang KT and Khalili K. Wiley-Blackwell Publishing, NJ. 2010; 113-228.
90. Goel A, Nagasaka T, Hamelin R, Boland CR. An optimized pentaplex PCR for detecting mismatch repair-deficient colorectal cancers. PLoS One. 2010; 5(2): e9393: 1-9. doi: 10.1371/journal.pone.0009393.
91. Goel A. DNA Methylation-based fecal biomarkers for the noninvasive screening of gastrointestinal cancers. Future Oncology. 2010; 6(3): 333-336.
92. Nagasaka T, Rhees J, Goel A, et al. Somatic hypermethylation of MSH2 is frequent event in Lynch syndrome colorectal cancers. Cancer Research. 2010; 70(8): 3098-3108. doi: 10.1158/0008-5472.CAN-09-3290
93. Arostegui JI, Saldana MDL, Goel A, et al. A somatic NLRP3 mutation as a cause of sporadic case of CINCA/NOMID syndrome. Novel evidences of the role of low-level mosaicism as pathophysiological mechanism underlying Mendelian inherited diseases. Arthritis and Rheumatism. 2010; 62(4): 1158-1166. doi: 10.1002/art.27342
94. Goel A, Xicola RM, Nguyen TP, et al. Aberrant DNA methylation in hereditary non-polyposis colorectal cancer without mismatch repair deficiency. Gastroenterology. 2010; 138: 1854-1862.
95. Boland CR, Goel A . Microsatellite instability in colorectal cancer. Gastroenterology. 2010; 138: 2073-2087.
96. Boland CR, Goel A. Clearing the air on smoking and colorectal cancer. Journal of National Cancer Institute. 2010; 102 (14): 996-997. doi: 10.1093/jnci/djq241
97. Paradise WA, vesper BJ, Goel A, et al. Nitic oxide: Perspectives and emerging studies of a well-known cytotoxin. International Journal of Molecular Sciences. 2010; 11: 2715-2745.
98. Link A, Balaguer F, Goel A, et al. Fecal microRNAs: novel biomarkers for colon cancer screening. Cancer Epidemiology Biomarkers and Prevention. 2010; 19(7): 1766-1774.
99. Balaguer F, Link A, Goel A , et al. Epigenetic silencing of miR-137 is an early event in colorectal carcinogenesis. Cancer Research. 2010; 70(16): 6609-6618. doi: 10.1158/0008-5472.CAN-10-0622
100. Goel A, Aggarwal BB. Curcumin, the golden spice from Indian saffron, is a chemosensitizer and radiosensitizer for tumors; and chemoprotector and radioprotector for normal organs. Nutrition and Cancer. 2010; 62(7): 919-930. doi: 10.1080/01635581.2010.509835
101. Link A, Balaguer F, Goel A. Cancer Chemoprevention by dietary polyphenols: Promising role for epigenetics. Biochemical Pharmacology. 2010; 80: 1771- 1792. doi: 10.1016/j.bcp.2010.06.036
102. Gupta S, Ashfaq R, Goel A, et al. Sporadic microsatellite instability may be uncommon among individuals of Hispanic origin with colorectal cancer. Cancer. 2010; 116(21): 4965-4972.
103. Goel A, Nagasaka T, Spiegel J, et al. Low frequency of Lyynch syndrome among young patients with nonfamilial colorectal cancer. Clinical Gastroenterology and Hepatology. 2010; 8(11): 966- 971.
104. Kraus S, Goel A, Arber N. Blood-based peptide, genetic, and epigenetic biomarkers for diagnosing gastrointestinal cancers. Expert Opinions on Medical Diagnostics. 2010; 4(6): 1-13.
105. Giraldez MD, Balaguer F, Goel A, et al. Frequency of hereditary syndromes in early-onset nonpolyposis colorectal cancer. Clinical Cancer Research. 2010; 16(22); 5402-5413.
106. Goel A, Nguyen TP, Leung HE, et al. De novo constitutional MLH1 epimutation confer early-onset colorectal cancer in two new sporadic Lynch syndrome cases, with derivation of the epimutation on the paternal allele in one. International Journal of Cancer. 2011; 128(4): 869-878. doi: 10.1002/ijc.25422
107. Goel A. Somatostatin methylation as a biomarker for gastric cancer: Ready for “prime time” or for further validation? Digestive Diseases and Sciences. 2011; 56(1): 1-3.
108. Goel A,Balaguer F. Serrated pathway to colorectal neoplasia: A molecular perspective. Current Colorectal Cancer Reports . 2011; 7: 42-49.
109. Chadha VJ, Goel A, Dhawan D. Regulatory role of zinc in the biokinetics and biodistribution of 65Zn during the initiation of experimentally induced colon cancer. Nutrition and Cancer. 2011; 63(2): 212-217. doi: 10.1080/01635581.2011.523167
110. Jover R, Nguyen TTP, Goel A, et al. Colorectal cancers with the CpG island methylator phenotype do not benefit from 5-fluorouracil-based adjuvant chemotherapy. Gastroenterology. 2011; 140(4): 1174-1181.
111. Carethers JM, Goel A. Our new AGA institute president- C. Richard Boland, M.D. Gastroenterology. 2011; 140: 1675-1679.
112. Takahashi M, Koi M, Balaguer F, Boland CR, Goel A. MSH3 mediates sensitization of colorectal cancer cells to cisplatin, oxaliplatin and a poly(ADPribose) polymerase inhibitor. Journal of Biological Chemistry. 2011; 286(14); 12157- 12165. doi: 0.1074/jbc.M110.198804
113. Reuter S, Gupta SC, Park B, Goel A, Aggarwal BB. Epigenetic changes by curcumin and related spice-derived nutraceuticals. Genes and Nutrition. 2011; 6(2): 93- 108.
114. Gasche JA, Hoffmann J, Boland CR, Goel A. Interleukin-6 promotes tumorigenesis by altering DNA methylation patterns in oral cancer cells. International Journal of Cancer. 2011; 129(5): 1053-1063.
115. Nishida N, Goel A. Genetic and epigenetic signature of hepatocellular carcinoma: a systematic review. Current Genomics. 2011; 12: 130-137.
116. Mori Y, Olaru AV, Goel A, et al. Methylation microarray-based scanning identifies novel colorectal cancer biomarkers. Endocrine Related Cancer. 2011; 18(4): 465-478.
117. Balaguer F, Moreira L, Goel A, et al. Lynch syndrome colorectal cancers display a unique miRNA profiles. Clinical Cancer Research. 2011; 17(19): 6239-6249.
118. Ramamoorthy S, Deveraj B, Miyai K, et al. JC virus T-antigen expression in anal carcinoma. Cancer. 2011; 117: 2379-2385.
119. Goel A. Colorectal cancer: Sailing with a T cell EMAST. Digestive Diseases and Sciences. 2012; 57(1): 1-3.
120. Toiyama Y, Goel A. The diagnostic, prognostic and predictive potential of microRNA biomarkers in colorectal cancer. Current Colorectal Cancer Reports. 2012; 8(1): 22-31.
121. Toiyama Y, Yasuda H, Saigusa S, et al. Co-expression of hepatocyte growth factor (HGF) and c-Met predicts peritoneal dissemination established by autocrine HGF/c-Met signaling in gastric cancer. International Journal of Cancer. 2012; 130(15): 2912-2921.
122. Garcia M, Choi C, Kim HR, et al. Moderate levels of microsatellite instability are associated with recurrent distant metastasis in stage II and III primary colorectal cancers. Gastroenterology. 2012; 143(1): 48-50.
123. Yurgelun MB, Goel A, Hornick JL, et al. Microsatellite instability and DNA mismatch repair protein deficiency in Lynch syndrome colorectal polyps. Cancer Prevention Research. 2012; 5(4): 574-582.
124. Shen Y, Takahashi M, Byun HM, et al. Boswellic acid modulates DNA methylation status in colorectal cancer cells. Cancer Biology and Therapy. 2012; 13(7): 542-552. doi: 10.4161/cbt.19604
125. Nishida N, Kudo M, Nagasaka T, Ikai I, Goel A. Characteristic patterns of DNA methylation alterations predict emergence of human hepatocellular carcinoma. Hepatology. 2012; 56(3): 994-1003.
126. Bouvard V, Bann RA, Grosse Y, et al. Carcinogenicity of malaria and some of the polyomaviruses. Lancet Oncology. 2012; 13(4): 339-340.
127. Brim H, Lee E, Abu-Asab MS, et al. Genomic aberrations in an african American colorectal cancer cohort reveal a MSI-specific profile and an amplification of chromosome X in male patients. PLoS One. 2012; 7(8); e40392.
128. Hur K, Han TS, Jung EJ, et al. Upregulated expression of sulfatases (Sulf-1 and Sulf-2) as prognostic and metastasis predictive markers in human gastric cancer. Journal of Pathology. 2012; 228(1); 88-98. doi: 10.1002/path.4055
129. Link A, Becker V, Goel A, Wex T, Malfertheiner P. Potential of fecal miRNAs as novel biomarkers for pancreatic cancer screening. PLoS One. 2012; 7(8); e42933.
130. Chandran B, Goel A. A randomized, pilot study to assess the efficacy and safety of curcumin compared to diclofenac sodium in the management of patients with active rheumatoid arthritis. Phytotherapy Research. 2012; 26(11): 1719- 1725. doi: 10.1002/ptr.4639
131. Antelo M, Balaguer F, Shia J, et al. High degree of LINE-1 hypomethylaiton is a unique feature of early-onset colorectal cancer. PLoS One. 2012; 7(9): e45357.
132. Takahashi M, Cuatrecasas M, Balaguer F, et al. The clinical significance of miR-148a as a predictive biomarker in patients with colorectal cancer. PLoS One. 2012; 7(10): e46684.
133. Takahashi M, Cuatrecasas M, Balaguer F, et al. The clinical significance of miR-148a as a predictive biomarker in patients with colorectal cancer. PLoS One. 2012; 7(10): e46684.
134. Gasche J, Goel A. Epigenetic mechanisms in oral carcinogenesis. Future Oncology. 2012; 8(11): 1407-1425.
135. Takahashi M, Sung B, Shen Y, et al. Boswellic acid exerts anti-tumor effects in colorectal cancer cells by modulating the expression of let-7 and miR-200 family of microRNAs. Carcinogenesis. 2012; 33(12): 2441-2449. doi: 10.1093/carcin/bgs286
136. Goel A, Boland CR. Epigenetics of colorectal cancer. Gastroenterology. 2012; 143: 1442-1460.
137. Hur K, Takahashi M, Balaguer F, et al. MicroRNA-200c modulates epithelial-to-mesenchymal transition (EMT) in human colorectal cancer metastasis. Gut. 2013; 62(9): 1315-1326.
138. Shakibaei M, Mobasheri A, Busch F, Lueders C, Goel A. Curcumin enhances the effect of chemotherapy against colorectal cancer cells by abrogation of NF-kB and Src protein kinase signaling pathway. PLoS One. 2013; 8(2): e57218. doi: 10.1371/journal.pone.0057218
139. Link A, Balaguer F, Shen Y, et al. Curcumin modulates DNA methylation in colorectal cancer cells. PLoS One. 2013; 8(2): e57709. doi: 10.1371/journal.pone.0057709
140. Toiyama Y, Takahashi M, Hur K, et al. Serum miR-21 as a promising biomarker for early detection and prognosis of colorectal cancer. Journal of National Cancer Institute. 2013; 105(12): 849-859. doi: 10.1093/jnci/djt101
141. Wodarz D, Boland CR, Goel A, Komarova N. Relationship between CIMP status and the de novo methylation kinetics in colorectal cancer cell lines. Biology Direct. 2013; (8): 14.
142. Nishida N, Kudo M, Nishimura T, et al. Unique association between global DNA hypomethylation and chromosomal alterations in human hepatocellular carcinoma. PLoS One. 2013; 8(9): e72312. doi: 10.1371/journal.pone.0072312
143. Ashktorab H, Wansley D, Rahi H, et al. Towards a comprehensive and systematic methylome signature in colorectal cancer. Epigenetics. 2013; 8(8): 807-815. doi: 10.4161/epi.25497
144. Toiyama Y, Yasuda H, Saigusa S, et al. Increased expression of slug and vimentin as novel predictive biomarkers for lymph node metastasis and poor prognosis in colorectal cancer patients. Carcinogenesis . 2013; 34(11): 2548-2557. doi: 10.1093/carcin/bgt282
145. Sadamori H, Yagi, T, Shigeyasu K, et al. Advanced hepatocellular carcinoma with lymph node metastasis showing epithelial to mesenchymal transition effectively treated with systemic chemotherapy: A case report. Hepatology Research. 2013; 43(12): 1368-1373. doi: 10.1111/hepr.12080
146. Sanmukhani J, Satodia V, Trivedi J, et al. Efficacy and safety of curcumin in major depressive disorder. Phytotherapy Research. 2014; 28(4): 579-585. doi: 10.1002/ptr.5025
147. Hur K, Cejas P, Feliu J, Moreno-Rubio J, et al. Hypomethylation of long interspersed nuclear element-1 (LINE-1) leads to activation of proto-oncogenes in human colorectal cancer metastasis. Gut. 2014; 63(4): 635-646.
148. Shakibaei M, Buhrmann C, Kraehe P, Shayan P, Lueders C, Goel A. Curcumin chemosensitizes 5-fluorouracil resistant MMR-deficient human colon cancer cells in high density cultures. PLoS One. 2014; 9(1): e85397. doi: 10.1371/journal.pone.0085397
149. Toiyama Y, Hur K, Tanaka K, et al. Serum miR-200c is a novel prognostic and metastasis-predictive biomarker in patient with colorectal cancer. Annals of Surgery . 2014; 259(4): 735-743.
150. Yamada A, Minamiguchi S, Sakai Y, et al. Colorectal advanced neoplasms occur through dual carcinogenesis pathways in individuals with coexisting serrated polyps. PLoS One. 2014; 9(5): e98059.
151. Ashktorab H, Daremipouran M, Goel A, et al. DNA methylome profiling identifies novel methylated genes in African American patients with colorectal neoplasia. Epigenetics. 2014; 9(4): 503-512. doi: 10.4161/epi.27644
152. Link A, Balaguer F, Nagasaka T, Boland CR, Goel A. MicroRNA miRJ1- 5p as a potential biomarker for JC virus infection in the gastrointestinal tract. PLoS One. 2014; 9(6): e100036.
153. Shigeyasu K, Tanakaya K, Nagasaka T, et al. Early detection of metachronous bile duct cancer in a patient with Lynch syndrome. Surgery Today. 2014. doi: 10.1007/s00595-013-0669-3
154. Okugawa Y, Toiyama Y, Goel A. An update on microRNAs as colorectal cancer biomarkers: Where are we and whats next? Expert Opinions on Medical Diagnostics. 2014; 14(8): 999-1021. doi: 10.1586/14737159.2014.946907
155. Perez-Carbonell L, Balaguer F, Toiyama Y, et al. IGFBP3 methylation is a novel diagnostic and predictive marker in colorectal cancer. PLoS One. 2014; 9(8): e104285.
156. Butcher LD, Garcia M, Ueno H, Goel A, Boland CR. Immune response to JC Virus T antigen in patients with and without colorectal neoplasia. Gut Microbes. 2014; 5(4): 468-475.
157. Shigeyasu K, Tazawa H, Hashimoto Y, et al. Fluorescent virus-guided capturing system of human colorectal circulating tumor cells for non-invasive companion diagnostics. Gut. 2014. doi: 10.1136/gutjnl-2014-306957
158. Buhrmann C, Kraehe P, Lueders C, Shayan P, Goel A, Shakibaei M. Curcumin suppresses crosstalk between colon cancer stem cells and stromal fibroblasts in the tumor microenvironment. Potential role of EMT PLoS One. 2014; e107514.
159. Toiyama Y, Okugawa Y, Goel A. DNA methylation and microRNA biomarkers for noninvasive detection of gastric and colorectal cancer. Biochemical Biophysical Research Communications. 2014. doi: 10.1016/j.bbrc.2014.08.001
160. Okugawa Y, Toiyama Y, Hur K, et al. Metastasis-associated long noncoding RNA drives gastric cancer development and promotes peritoneal metastasis. Carcinogenesis. 2014.
161. Toiyama Y, Tanaka K, Kitajima T, et al. Elevated serum angiopoietin-like protein 2 correlates with the metastatic properties of colorectal cancer: a serum biomarker for early diagnosis and recurrence. Clinical Cancer Research. 2014.
162. Toden S, Goel A. The importance of diets and epigenetics in cancer prevention: A hope and promise for the future?. Alternative Therapies In Health and Medicine. 2014; 20(2): 6-11.

James Wei Tatt Toh, BSc, MBBS, FRACS

Conjoint Lecturer
University of Western Sydney
University of New South Wales
James Ruse Dr, Parramatta NSW 2150
Sydney NSW 2052, Australia

BiographyResearch InterestScientific ActivitiesPublications

Dr. James Toh is a Surgeon and Lecturer at University of Western Sydney and University of New South Wales. He is on the Editorial Board of several international journals. He is also widely published in gastroenterology and colorectal topics.

His research interests include: Minimally invasive laparoscopic and endoscopic techniques with an interest in robotic techniques, and with a research focus in oncology, physiology and education.

PROFESSIONAL MEMBERSHIPS

• (2014 -Present): Colorectal Surgical Society Australia New Zealand (CSSANZ)
• (2014 ): GESA accreditation for colonoscopy
• (2014 -Present): Editorial Board of World Medical Student Journal
• (2014 -Present): Editorial Board of Journal of Clinical Medicine
• (2010 -Present): General Surgeons Australia (GSA)
• (2000-2005): National Rural Health Alliance (NRHA) member, friend of the NRHA since 2006
• (2000-2005): John Flynn Scholar – Bush Community Outreach programs, Aboriginal Medical Service programs, Flying Doctor service
• (2000-2005): Member of AMA


AWARDS AND SCHOLARSHIPS

• 2013 , University of New South Wales Clinical Associate Dean Teaching Award, Sydney South West Area Health Service Liverpool Hospital Best Registrar with Training Potential Award
• 2010, Sydney South West Area Health Service Communication and Customer Service Excellence Award
• 2000-2005, John Flynn Medicine Rural Scholarship
• 2004, Finalist in the Australian National Institute of Poetry, published in 2004 Anthology of Verse
• 1999, Premiers Trophy for HSC All-round Achievement
• 1999, Ross Medal for 3U English – top student in James Ruse; top 15 in NSW
• 1999, Castle Hill Police Station “Outstanding Youth in Excellence”
• 1999, Rio Tinto National Youth Science Forum
• 1999, Australian Institute of Agriculture Science and Technology Medal
• 1998, Premiers Award for top student in NSW in 3U Agriculture
• 1998, Baulkham Hills Shire “Outstanding Achiever in Excellence” for most outstanding youth in the Hills Shire 18-25 years at Orange Blossom Festival
• 1998, Integral Energy Science and Technology Award for Research Excellence
• 1998, Queens Trust Scholarship, Caltex Best All-Rounder in James Ruse
• 1997,Queens Trust Scholarship, Caltex Best All-Rounder in James Ruse
• University of Sydney Award for top student in School Certificate in NSW
• Prizes in Australian Maths Competitions, Medal in American Maths Competition, multiple school awards including bronze awards, head teacher awards, principals medal

1. Toh J, Yabe E, Ong E, Chapuis P, Bokey L. Management of sub-5mm rectal carcinoids with lymph node metastases. Oxford Journals Gastroenterology Report. 2014; gou073
2. Toh J, Gibson K, Vanlioglu B, Ang S, Ong E. Rapid progression from perianal abscess to Fourniers gangrene. ANZ Journal of Surgery. 2014. : 10.1111/ans.12811.
3. Toh J, Ong E, Wilson R. Hypomagnesaemia associated with Long Term Use of Proton Pump Inhibitors. Oxford Journals Gastroenterology Report. 2014; gou054
4. Toh J, Chen Z, Morris D, Chen C. Near fatal 5-FU toxicity – remarkable effects of high dose sucralfate. Journal of Chemotherapy. 2014.
5. Mackay G, Morgan M, Toh J, et al. Improved short-term outcomes of laparoscopic versus open resection for colon and rectal cancer in an area health service: a multicenter study. Dis Colon Rectum. 2012; 5(1):42-50. doi: 10.1097/DCR.0b013e318239341f.
6. Toh JWT, Rahman K, Kozman D. Mucinous tumour in ileal pouch post restorative proctocolectomy and ileal pouch anal anastomosis for Familial Adenomatous Polyposis. Gastro Open J. 2015; 1(2): 59-60. doi: 10.17140/GOJ-1-109

Kaushal Kishor Prasad, MD, PDC, CFN, MAMS, FICPath

Additional Professor and Chief
Division of GE Histopathology
I/C Division of GE Enzymology
Department of Superspeciality of Gastroenterology
Postgraduate Institute of Medical Education and Research
Chandigarh (UT) -160 012, INDIA

BiographyResearch InterestScientific ActivitiesPublications

Dr. Kaushal Kishor Prasad (KKP) is Additional Professor (Division of Gastrointestinal Histopathology) in the Department of Superspeciality of Gastroenterology at Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India. KKP is in the panels of experts for the World Association of Societies of Pathology and Laboratory Medicine (WASPaLM) and SAARC Academy of Cytopathology & Histopathology (SACH). KKP has modified the Marsh-Oberhuber classification of celiac disease, coined the term “Follicular esophagitis” for a novel histopathological entity in esophagus and developed the rice based gluten-free composite flour cookies for celiac disease patients in collaboration with food technologist. KKP is reviewer for the extramural and intramural research project proposals especially on celiac disease. His main research areas of interest are celiac disease, microscopic colitis, extrahepatic portal vein obstruction and inflammatory bowel disease. He published sixteen articles on celiac disease in international journals of high repute and three articles in national journal. KKP is international editorial board member for more than 20 international journals and reviewer for more than 50 international journals. He travelled across the world and delivered invited lectures and presented more than 160 scientific papers in more than 100 scientific meetings. He is life member/ member of 12 international and 10 national professional societies. KKP also holds several key positions in various national and international scientific societies. KKP has received 26 awards in international and national scientific forums including prestigious ISG-SR Naik award and V R Khanolkar award for his original work. KKP has authored 75 widely cited papers and has contributed in more than 10 books in the field of Gastroenterology. He is also iconic achiever for “The International Plato Award for Educational Achievement, International Hippocrates Award for Medical Achievement, Da Vinci Diamond – For Inspirational Accomplishment” etc. More information about KKP is available at http://pgimer.edu.in/PGIMER_PORTAL/PGIMERPORTAL/Department/Global/JSP/home_dept.jsp?CP=Eng&deptid=d15&B2=GO

His research interests include: Celiac disease, Microscopic colitis, EHPVO, IBD, IBS, Alcohol & gut, Helicobacter pylori.

PROFESSIONAL AWARDS/ PRIZES/ HONORS/ SCHOLARSHIPS RECEIVED:


1. Awarded Gold Medal and Certificate of merit for getting first position in Final MBBS University Examination.
2. Text Book of Surgery for getting first position in 1st MBBS University Examination. 3. Achieved proficiency in IAP Quiz, held in 1989 by IAP at PMC, Dhanbad.
4. Winner in Clinical Review VI, held on 25th Jan 1992 by the Deptt. of Medicine,JLNMCH, Bhagalpur.
5. Special State Merit Scholarship from 1984 to 1991.
6. Wrote Foreword for booklet Clinical Assist “Quick Reference Disease Management Guide” by CMP Medica Asia.
7. Contributed multiple choice questions (MCQs) to NIMSET database for MD, MS, DM & MCh entrance exam of Nizam’s Institute of Medical Sciences, Hyderabad.
8. Contributed multiple choice questions (MCQs) to AIIMS database for DM Gastroenterology entrance exam of All India Institute of Medical Sciences, New Delhi.
9. Contributed multiple choice questions (MCQs) to PGIMER database for screening of Senior resident Gastroenterology of Postgraduate Institute of Medical Education & Research, Chandigarh.
10. External examiner in Pathology (Undergraduate [MBBS]): Ranchi University, Patna University, Kumaon University.
11. External examiner in Pathology (Postgraduate [MD, DCP]): Patna University, Santosh University, Rohilkhand University.
12. Pathological and microbiological changes in small intestinal mucosa of alcoholic liver disease with cirrhosis. Presented at midterm conference of INASL held in association with 45th annual conference of ISG at Jaipur in Oct 2004 and awarded the ‘Best paper award in plenary session’.
13. Intestinal mucosal enzyme activities in celiac disease – a preliminary study. Presented in 53rd Annual conference of IAPM at Pune in Nov 2004 and awarded the ‘Best poster award in poster session’.
14. Association of cervical esophageal web and celiac disease. Presented in 46th annual conference of ISG at Visakhapatanam in Nov 2005 and awarded the ‘ISG – Win-medicare poster session award - 2005’
15. Brush border enzyme profiles in patients with celiac disease. Presented in 46th annual conference of ISG at Visakhapatanam in Nov 2005 and awarded the ‘ISG - Systopic poster session award - 2005’.
16. Small intestinal mucosal changes in alcoholics with chronic pancreatitis. Presented in 46th annual conference of ISG at Visakhapatanam in Nov 2005 and awarded the ‘ISG - Systopic poster session award - 2005’.
17. Celiac disease in Chandigarh: A population survey. Presented in 46th annual conference of ISG at Visakhapatanam in Nov 2005 and awarded the ‘ISG – Systopic poster session award - 2005’.
18. Histologic lesion variability of the duodenal mucosa in pediatric celiac disease. Presented in Indo-British Ped Con 2006 at New Delhi in Oct 2006 and awarded the text book ‘Rudolph’s Paediatrics’ for outstanding research work.
19. Microscopic colitis and serum serotonin levels. Presented in 56th Annual conference of IAPM at Chandigarh in Nov 2007 and awarded the ‘Best poster award in poster session’
20. Study of duodenal mucosal enzyme activities and morphological changes in irritable bowel syndrome awarded the “United States and Canadian Academy of Pathology (USCAP) Bursary” at $ 1,000 USD to attend 27th IAP International Congress (IAP 2008) at Athens, Greece in Oct 2008.
21. Terminal ileal mucosal morphology in microscopic colitis awarded the “United European Gastroenterology Federation (UEGF) Travel Grant for Basic Scientists” at € 1,000 Euro to attend 16th UEGW 2008 at Vienna, Austria in Oct 2008.
22. Correlation of serology to histopathology in celiac disease. Presented in 18th National Conference of Pediatric Gastroenterology, Hepatology and Nutrition at Navi Mumbai in Oct-Nov 2008 and awarded the ‘Best paper award in pediatric gastroenterology session’.
23. (i) Lymphocytic gastritis and celiac disease: evidence of a positive relationship; and (ii) Diagnostic value of duodenal bulb biopsy in patients with celiac disease awarded the “Royal college of Pathologists of Australasia (RCPA) Quality Assurance Programs Pty Limited Congress Grant” to attend XXV World Congress of Pathology and Laboratory Medicine at Sydney, Australia in Mar 2009.
24. Correlation of growth hormone analysis with linear growth in extrhepatic portal vein obstruction in children. Presented in National Mid-Term Conference of IAP; Pediatric Gastroenterology Subspeciality Chapter at Jaipur in Apr 2009 and awarded the ‘2nd Best paper award in pediatric gastroenterology session’.
25. Histomorphologic parameters of terminal ileal mucosa in microscopic colitis.Awarded the Rs. 60,000 INR as “Indian Society of Gastroenterology (ISG) Travel Fellowship for Asia Pacific Digestive Week 2009” at Taipei, Taiwan in Sept 2009.
26. Growth retardation in extrahepatic portal vein obstruction: Digestive orendocrine abnormality? awarded the “United European Gastroenterology Federation (UEGF) Travel Grant for Basic Scientists” at € 1,000 Euro to attend GASTRO 2009 - UEGW/WCOG at London, United Kingdom in Nov 2009.
27. (i) Lymphocytic esophagitis in children with celiac disease: A novel finding; and (ii) Prevalence of eosinophilic esophagitis in pediatric population: Singlecenter experience in Northwestern India awarded the “Canadian pediatric Grant” to attend 26th IPA Congress of Pediatrics, Johannesburg, South Africa in Aug 2010.
28. Conferred the Fellow of Indian College of Pathologists (FICPath) in year 2010 by Indian College of Pathologists, an academic wing of Indian Association of Pathologists and Microbiologists (IAPM).
29. Elected the Member of National Academy of Medical Sciences (MAMS) in year 2010 in recognition of significant contribution for the advancement of Medical Sciences.
30. Prevalence of cagA and vacA genotypes of H. Pylori as a putative virulence marker in dyspeptic patients. Presented in 51st annual conference of ISG at Hyderabad in Nov 2010 and awarded the 2nd Best paper award of ‘ISG – Winmedicare poster session award - 2010’
31. Spectrum of esophageal mucosal lesions in pediatric celiac disease: a prospective controlled study. Presented in 51st annual conference of ISG at Hyderabad in Nov 2010 and awarded the 2nd Best paper award of ‘ISG – Winmedicare poster session award - 2010’.
32. ICMR expert group on celiac disease: “Sensitization of medical teachers in India towards celiac disease.”
33. Spectrum of esophageal mucosal lesions in pediatric celiac disease: a prospective controlled study. Presented in International CME in Pathology – Histopathology and Cytopathology at Goa in Feb 2011 and awarded the 3rd Best faculty oral paper award – 2011.
34. Evaluation of PCR using MPB64 primers for rapid diagnosis of Mycobacterium tuberculosis in endoscopic biopsy specimens of gastrointestinal tuberculosis. Presented in 3rd biennial conference of GISI at Manipal in May 2011 and awarded the Best faculty poster award – 2011.
35. ISG-SR Naik Award (2011) for the best published work in the field of diseases of the digestive tract and liver, and other sciences as related to these areas in 2009-2010. The award carried a certificate of honour and a cash of Rs. 20,000 INR and awarded during ISGCON 2011 at Coimbatore in Nov 2011.
36. Proinflammatory cytokines and IL-10 profile in ulcerative colitis patients. Presented in 38th Annual conference of ACBI (ACBICON 2011) at Gwalior in Dec 2011 and awarded the M.G.I.M.S. (Sewagram) Award’.
37. Invited by Finnish Coeliac Society to present the work on celiac disease in 26th AOECS General Assembly & International Coeliac Disease Scientific Conference at Helsinki, Finland in Sept 2012.
38. Effect of shunt surgery on small intestinal morphological and functional alterations in patients with EHPVO awarded the “International Academy of Pathology (IAP) Bursary” at $ 1,200 USD to attend 29th IAP International Congress (IAP 2012) at Cape Town, South Africa in Sept-Oct 2012.
39. V R Khanolkar Award (2011) for the best published research work. The award carried a certificate of honour and awarded during APCON 2013 at Aurangabad in Dec 2013.
40. Microscopic colitis - a missed diagnosis in irritable bowel syndrome. Presented in International CME in Pathology – Histopathology and Cytopathology at Goa in Feb-Mar 2014 and awarded the Best faculty Poster paper award – 2014.
41. Panels of experts in SAARC Academy of Cytopatology & Histopathology (SACH).
42. Panels of experts for the World Association of Societies of Pathology and Laboratory Medicine (WASPaLM): Education and Visiting Lecturer Program (EVLP) .

ORIGINAL ARTICLES / *SHORT COMMUNICATIONS

International:

1. Mohindra S, Yachha SK, Srivastava A, et al. Celiac disease in Indian children: Assessment of clinical, nutritional and pathologic characteristics. J Health Popul Nutr.2001; 19(3): 204-8.
2. Agarwal G, Prasad KK, Kar DK, Krishnani N, Pandey R, Mishra SK. Indian primary hyperparathyroidism with parathyroid carcinoma do not differ in clinicoinvestigative characteristics from those with benign parathyroid pathology. World J Surg. 2006; 30(5): 732-42. doi: 10.1007/s00268-005-0366-5
3. Kaur S, Vaishnavi C, Prasad KK, Ray P, Kochhar R. Comparative role of antibiotic and proton pump inhibitor in experimental Clostridium difficile infection in mice. Microbiol Immunol. 2007; 51(12): 1209-14.
4. Prasad KK, Thapa BR, Sharma AK, Nain CK, Singh K. Reassessment of diagnostic value of antral nodularity for Helicobacter pylori infection in children. Minerva Gastroenterol Dietol. 2008; 54(1): 1-6.
5. Sinha SK, Nain CK, Udawat HP, et al. Cervical esophageal web and celiac disease. J Gastroenterol Hepatol. 2008; 23(7 Pt 1): 1149-52. doi: 10.1111/j.1440-1746.2008.05452.x.
6. Bhonchal S, Nain CK, Prasad KK, et al. Functional and morphological alterations in small bowel mucosa of chronic alcoholics. J Gastroenterol Hepatol. 2008; 23(7 Pt 2): e43-8. doi: 10.1111/j.1440-1746.2007.05080.x
7. Prasad KK, Thapa BR, Nain CK, Sharma AK, Singh K. Brush border enzymeactivities in relation to histologic lesion in pediatric celiac disease. J Gastroenterol Hepatol. 2008; 23(8 Pt 2): e348-52. doi: 10.1111/j.1440-1746.2007.05248.x
8. Prasad KK, Thapa BR, Lal S, Sharma AK, Nain CK, Singh K. Lymphocytic gastritis and childhood celiac disease: evidence of a positive relation. J Pediatr Gastroenterol Nutr. 2008; 47(5): 568-72.
9. Prasad KK, Thapa BR, Nain CK, Singh K. Assessment of the diagnostic value of duodenal bulb histology in patients with celiac disease, using multiple biopsy sites. J Clin Gastroenterol. 2009; 43(4): 307-11. doi: 10.1097/MCG.0b013e31815b9d11.
10. Rana SV, Sharma S, Sinha SK, Kaur J, Prasad KK, Singh K. Influence of previously ingested wheat on fasting breath hydrogen in celiac patients. Dig Dis Sci. 2009; 54(6): 1276-9. doi: 10.1007/s10620-008-0496-3.
11. Bhatia T, Sharma RK, Prasad KK, Prasad K. Studies on some physical properties of protein rich legume (Lens esculantus) splits. Asian J Chem. 2009; 21(10): S103-7.
12. Sikander A, Rana SV, Sinha SK, et al. Serotonin transporter promoter variant: Analysis in Indian IBS patients and control population. J Clin Gatroenterol. 2009; 43(10): 957-61. doi: 10.1097/MCG.0b013e3181b37e8c.
13. Masoodi I, Kochhar R, Dutta U, et al. Fecal lactoferrin, myeloperoxidase and serum C-reactive are effective biomarkers in the assessment of disease activity and severity in patients with idiopathic ulcerative colitis. J Gastroenterol Hepatol. 2009; 24(11): 1768-74. doi: 10.1111/j.1440-1746.2009.06048.x.
14. Sikander A, Rana SV, Sharma SK, et al. Association of alpha 2A adrenergic receptor gene (ADR_lpha2A) polymorphism with irritable bowel syndrome, microscopic & ulcerative colitis. Clin Chim Acta. 2010; 411(1-2): 59-63. doi: 10.1016/j.cca.2009.10.003.
15. Prasad KK, Thapa BR, Nain CK, Singh K. The frequency of histologic lesion variability of the duodenal mucosa in children with celiac disease. World J Pediatr. 2010; 6(1): 60-4 doi: 10.1007/s12519-010-0008-3.
16. Kaur S, Vaishnavi C, Ray P, Kochhar R, Prasad KK. Effect of biotherapeutics on cyclosporin-induced Clostridium difficile infection in mice. J Gastroenterol Hepatol. 2010; 25(4): 832-8. doi: 10.1111/j.1440-1746.2009.06135.x.
17. Prasad K, Janve B, Sharma RK, Prasad KK. Compositional characterization of traditional medicinal plants: Chemo-metric approach. Arch Appl Sci Res. 2010; 2(5): 1-10.
18. Sidhu GS, Thapa BR, Rawal P, et al. Brush border enzymes and absorptive capacity in extrahepatic portal venous obstruction in children. Hepatol Int. 2010; 4: 762-6. doi: 10.1007/s12072-010-9211-5.
19. Rawal P, Thapa BR, Prasad R, Prasad KK, Nain CK, Singh K. Zinc supplementation to patients with celiac disease – Is it required? J Trop Pediatr. 2010; 56(6): 391-7. doi: 10.1093/tropej/fmq011.
20. Rawal P, Thapa BR, Nain CK, Prasad KK, Singh K. Changing clinical spectrum of celiac disease in India. Iran J Pediatr. 2010; 20(4): 459-65.
21. Prasad K, Prakash P, Prasad KK. Some studies on formulation of rice based functional cookies for celiac. World Journal of Dairy & Food Sciences. 2010; 5(2): 164-72.
22. Masoodi I, Kochhar R, Dutta U, et al. Evaluation of Fecal Myeloperoxidase as a Biomarker of Disease Activity and Severity in Ulcerative Colitis. Dig Dis Sci. 2012; 57(5): 1336-40. doi: 10.1007/s10620-012-2027-5.
23. Kochhar R, Sachdev S, Kochhar R (Jr), et al. Prevalence of coeliac disease in healthy blood donors: A study from North India. Dig Liver Dis. 2012; 44(6): 530-2. doi: 10.1016/j.dld.2012.01.004.
24. Handu AT, Prasad KK, Thapa BR, Menon P, Batra YK, Rao KL. A prospective study comparing histology and enteric enzyme function of patients with extrahepatic portal vein obstruction before and after shunt surgery. Eur J Gastroenterol Hepatol. 2012; 24(10): 1219-26. doi: 10.1097/MEG.0b013e3283567ca3.
25. Rana SV, Sharma S, Malik A, et al. Small Intestinal Bacterial Overgrowth and Orocecal Transit Time in Patients of Inflammatory Bowel Disease. Dig Dis Sci.2013; 58(9): 2594-8. doi: 10.1007/s10620-013-2694-x.
26. Sharma K, Sinha SK, Sharma A, et al. Multiplex PCR for Rapid Diagnosis of Gastrointestinal Tuberculosis. J Glob Infect Dis. 2013; 5(2): 49-53.27. doi: 10.4103/0974-777X.112272.
27. Rana SV, Sharma S, Kaur J, et al. Relationship of cytokines, oxidative stress and GI motility with bacterialovergrowth in ulcerative colitis patients. J Crohns Colitis. 2014; S1873-9946(14): 00011-7. doi: 10.1016/j.crohns.2014.01.007


National:


1. Wagholikar GD, Sikora SS, Pandey R, et al. Morphological changes in bile ducts following preoperative biliary stenting. Indian J Gastroenterol. 2003; 22(5): 166-9.
2. Rana SV, Sharma S, Sinha SK, Prasad KK, Bhasin DK, Singh K. Orocecal transit time in patients with celiac disease from North India: a case control study. Trop Gastroenterol. 2008; 29(2): 98-100.
3. Noor MT, Kochhar R, Prasad KK, Goenka MK, Vaiphei K, Singh K. Portal hypertensive vasculopathy: Endoscopic and histological appearances in the rectosigmoid in portal hypertension of diverse aetiology. J Dig Endosc. 2010; 1(2): 42-9.
4. Kaur S, Vaishnavi C, Prasad KK, Ray P, Kochhar R. Effect of Lactobacillus acidophilus and epidermal growth factor in experimentally induced Clostridium difficile infection. Indian J Med Res. 2011; 133(4): 434-41.
5. Kaur S, Vaishnavi C, Kochhar R, Prasad KK, Ray P. Effect of biotherapeutics on antitoxin IgG in experimentally induced Clostridium difficile infection. Indian J Med Microbiol.2012; 30(4): 431-6. doi: 10.4103/0255-0857.103764.
6. Kochhar R, Jain K, Thapa BR, et al. Clinical presentation of celiac disease among pediatric compared to adolescent and adult patients. Indian J Gastroenterol.2012; 31(3): 116-20. doi: 10.1007/s12664-012-0198-9.
7. Rana SV, Sharma S, Sinha SK, Prasad KK, Malik A, Singh K. Pro-inflammatory antinflammatory cytokine response in diarrhoea-predominant irritable bowel syndrome patients. Trop Gastroenterol. 2012; 33(4): 251-6. doi: http://dx.doi.org/10.7869/tg.2012.66
8. Rana SV, Sharma S, Prasad KK, Sinha SK, Singh K. Role of oxidative stress & antioxidant defence in ulcerative colitis patients from north India. Indian J Med Res. 2014; 139(4): 568-71.

Xiaofang Huo, MD, PhD

Instructor
Department of Internal Medicine
UT Southwestern Medical Center
VA North Texas Health Care System-Dallas
4500 South Lancaster Road
Dallas, Texas 75216, USA

BiographyResearch InterestScientific ActivitiesPublications

Dr. Huo obtained M.D. from North China Coal Medical College (1999) and Ph.D. from Peking Union Medical College (2005). After completing Ph.D, she completed her postdoctoral training in Internal Medicine- Liver and Digestive Diseases at the University of Texas Southwestern Medical Center at Dallas (2007-2012). She now works as Instructor at Internal Medicine department. For the past several years, she has worked closely with Drs. Rhonda Souza and Stuart Spechler to study the molecular mechanism of reflux diseases and the development and progression of Barrett’s esophagus. During this time period, she has published 11 original manuscripts, an editorial, and she has presented numerous abstracts at the annual meeting of the American Gastroenterological Association.

Her research interests include the early pathophysiology of Gastroesophageal reflux disease (GERD) at the cellular and molecular levels so that new medical treatments can be developed to improve symptom control, to eliminate inflammation, and to prevent the development of Barrett’s esophagus and esophageal adenocarcinoma.

HONORS AND AWARDS

• (2009) First Place of Poster, VA North Texas Health Care System, Dallas
• (2010) Fellow Travel Award, Gastroenterology Research Group
• (2011) Poster of Distinction, Digestive Diseases Week, San Diego


PROFESSIONAL SOCIETIES

• (2010-Present) American Gastroenterological Association Committees Fellowships
• (2010) Gastroenterology Research Group

1. Souza RF, Huo X, Mittal V, et al. Gastroesophageal reflux might cause esophagitis through a cytokine-mediated mechanism rather than caustic acid injury. Gastroenterology. 2009; 137(5): 1776-84. doi: 10.1053/j.gastro.2009.07.055
2. Huo X, Zhang HY, Zhang X, et al. Acid and Bile Salt-Induced CDX2 expression differs In in Esophageal Squamous Cell from GERD Patients with and without Barretts Esophagus. Gastroenterology. 2010; 139: 194-203. doi: 10.1053/j.gastro.2010.03.035
3. Zhang X, Yu C, Wilson K, et al. Malignant transformation of non-neoplastic Barretts epithelial cells through well-defined genetic manipulations. PLoS One. 2010; 5(9). doi: 10.1371/journal.pone.0013093
4. Zhang HY, Zhang Q, Zhang X, et al. Cancer-Related Inflammation and Barretts Carcinogenesis: Interleukin-6 and STAT3 Mediate Apoptotic Resistance in Transformed Barretts Cells. Am J PhysiolGastrointest Liver Physiol. 2011; 300(3): G454-60. doi: 10.1152/ajpgi.00458.2010
5. HuoX, Juergens S, Zhang X, et al. Deoxycholic acid causes DNA damage while inducing apoptotic resistance through NF-κB activation in benign Barretts epithelial cells. Am J PhysiolGastrointest Liver Physiol. 2011; 301(2): G278-86. doi: 10.1152/ajpgi.00092.2011
6. Zhang X, Cheng E, Huo X, et al. Omeprazole blocks STAT6 binding to the eotaxin-3 promoter in eosinophilic esophagitis cells. PLoS One. 2012; 7(11): e50037. doi: 10.1371/journal.pone.0050037
7. Yu C, Zhang Q, Zhang HY, et al. Targeting the intrinsic inflammatory pathway: honokiol exerts proapoptotic effects through STAT3 inhibition in transformed Barretts cells. Am J PhysiolGastrointest Liver Physiol. 2012; 303(5): G561-9. doi: 10.1152/ajpgi.00033.2012
8. Cheng E, Zhang X, Huo X, et al. Omeprazole blocks eotaxin-3 expression by oesophageal squamous cells from patients with eosinophilicoesophagitis and GORD. Gut. 2013; 62(6): 824-32. doi: 10.1136/gutjnl-2012-302250
9. Huo X, Zhang X, Yu C, et al. In oesophageal squamous cells exposed to acidic bile salt medium, omeprazole inhibits IL-8 expression through effects on nuclear factor-κB and activator protein-1. Gut. 2013; doi: 10.1136/gutjnl-2013-305533
10. Zhang Q, Yu C, Peng S, et al. . Gastroenterology. 2014; 146(2): 461-472. e6. doi: 10.1053/j.gastro.2013.10.011
11. Peng S, Huo X, Rezaei D, et al. In Barretts Esophagus Patients and Barretts Cell Lines, Ursodeoxycholic Acid Increases Antioxidant Expression and Prevents DNA Damage by Bile Acids. Am J Physiol Gastrointest Liver Physiol. 2014. 10.1152/ajpgi.00085.2014
12. Huo X. Therapeutic and chemopreventive effects of ursodeoxycholic acid (UDCA): potential role in patients with barrett’s esophagus. Gastro Open J. 2015; 1(4): 89-93. doi: 10.17140/GOJ-1-115

Jennifer L. Seminerio, MD

Assistant Professor of Medicine
Division of Gastroenterology
Medical University of South Carolina
25 Courtenay Drive, ART 7100A MSC 290
Charleston, SC 29425, USA

BiographyResearch InterestScientific ActivitiesPublications

Dr. Seminerio completed her residency in Internal Medicine at the Mayo Clinic in Rochester, MN and fellowship in Gastroenterology and Hepatology at University of Pittsburgh Medical Center in Pittsburgh, PA. Her clinical focus is in Inflammatory Bowel Disease (IBD) with interest in obesity and its effect on the gastrointestinal tract. Dr. Seminerio’s professional experience includes membership in the CCFA, IBD REACH, as well as recent participation as a fellow representative in the Cornerstones Best of DDW in IBD. During fellowship training, she had a specific focus in IBD having spent training in outpatient IBD clinic as well as inpatient IBD service.

Her research interests have focused on obesity and its effects on IBD as well as grant funded research on obesity and GI hormones.

HONORS AND AWARDS

• DDW Fellow Representative: Cornerstones Best of DDW (2014)
• Fellowship2Leadership Salix Fellows Program (2013)
• ACG Abstract Award Winner: Obesity and IBD (2012)
• T32 research award recipient (2012-2014)
• Young Alumni Award: Heidelberg University (2012)
• American Society for Clinical Pathology Award (2006)
for Academic Excellence and Achievement
• American Journal of Clinical Pathology (2006)
Award of excellence
• Clyde Lamb Award Winner (2003)
Heidelberg University
• All Conference and Academic All Conference (2000-2003)
Ohio Athletic Conference
Womens Track and Field
Heidelberg University
• All Region/All Ohio Soccer First Team (2002-2003)
Heidelberg University
• Verizon Academic All-American (2002)
Track and Field
Heidelberg University
• First Team Academic Conference Team (2002)
and First Team All-Conference
Womens Soccer
Heidelberg University
• Academic All Conference (2001)
Womens Basketball
Heidelberg University

MEMBERSHIP IN PROFESSIONAL AND SCIENTIFIC SOCIETIES


• AGA: American Gastroenterological Association (2013-present)
• WE Care (2013-present)
• American Society of Gastrointestinal Endoscopy (2011-present)
• American College of Gastroenterology (2011-present)
• American College of Physicians (2008-present)
• American Society of Clinical Pathologists (2005-2008)
• American Medical Association (2003-present)
• American Medical Student Association (2003-2008)
• American Medical Womens Association (2003-2008)

REFEREED ARTICLES

1. Jennifer L, Seminerio S, Keefe O. Jejunal Feeding in Patients With Pancreatitis. Nutr Clin Pract. 2014. doi: 10.1177/0884533614529164
2. Jennifer L, Seminerio S,Kevin M, et al. Singhi Medication-associated lesions of the GI tract. Gastrointestinal Endoscopy. 2014 : 79(1): 140-150. doi: 10.1016/j.gie.2013.08.027
3. Jennifer L, Seminerio S. Crohns Disease in the Malnourished Pregnant Female: A Case Presentation and Review of Literature. Pitt Digest. 2013; 5-6.
4. Jennifer L, Seminerio S,Edward V, et al. Infliximab for Crohns Disease: The First 500 Patients Followed Up Through 2009. Digestive Diseases Sciences. 2013; 58(3): 797-806. doi: 10.1007/s10620-012-2405-z
5. Jennifer L, Seminerio S, Aggarwal G,Sweetser S. 26-Year-Old Man with Recurrent Urinary Tract Infections. Mayo Clinic Proceedings. 2011; 86(6): 557-560. doi: 10.4065/mcp.2010.0600
6. Sandrine V, Yang C, Yuan Z, et al. Ouabain triggers preconditioning through activation of the Na,K-ATPase signaling cascade in rat hearts. CVR. 2007; 73: 488-496. doi: http://dx.doi.org/10.1016/j.cardiores.2006.11.003
7. Inman S, Davis N, Olson K, Lukaszek V, McKinley M, Seminerio S. Rapamycin preserves renal function compared with cyclosporine A after ischemia reperfusion injury. Urology. 2003; 62: 750-754. doi: 10.1016/S0090-4295(03)00475-8

Weibiao Cao, MD

Surgical and Gastrointestinal Pathologist
Associate Professor of Pathology and Laboratory Medicine
Associate Professor of Medicine
Department of Pathology & Medicine
Rhode Island Hospital and The Warren Alpert Medical School of Brown University
593 Eddy St, APC 12, Providence, RI 02903, USA

BiographyResearch InterestScientific ActivitiesPublications

Dr. Cao graduated from Zhejiang University School of Medicine, Hangzhou, China in 1986 and obtained an MD degree. He became a resident and attending physician from 1986 to 1994. From 1996 to 2007, he worked as a research associate and an assistant professor in Rhode Island Hospital and The Warren Alpert Medical School of Brown University, Providence, RI, USA. From 2007 to 2012 he finished his residency and GI fellowship training in pathology in Rhode Island Hospital and Brown University. Now he is an attending pathologist and associate professor in Department of Pathology and Medicine, Rhode Island Hospital and The Warren Alpert Medical School of Brown University, Providence, RI, USA.

His research interest includes: signal transduction pathway of the progression from Barretts Esophagus to esophageal adenocarcinoma, mechanisms of tumorigenesis from inflammatory bowel disease, smooth muscle contractility, calcium signaling, NADPH oxidases, bile acid receptors and signal transduction pathways.

POSTGRADUATE HONORS AND AWARDS

• Young Investigator Award Finalist (Clinical Science Category), Lifespan – Rhode Island Hospital 17th Annual Hospital Research Celebration, October 22, 2009
• Young Investigator Award Finalist (Basic Science Category), Lifespan – Rhode Island Hospital 9th Annual Hospital Research Celebration, October 25, 2001
• Young Investigator Award, 10th Biennial Meeting of the American Motility Society, Philadelphia, PA, 1998
• Second prize, National Scientific and Technological Advancement Award of China, 1998
• First Prize, Scientific Advancement, Ministry of Public Health, China, 1997
• Young Investigator Award, the 13th Asia Pacific congress on Diseases of Chest, Hong Kong, December 5-8, 1994
• First Prize, Academic Thesis, PUMC Hospital, Beijing, P.R. China, 1994
• Third Prize, Excellent Thesis, First National Endocrinological Conference by the Middle Aged and Youth of Chinese Medical Association (Thesis: Nitric oxide inhibits the production of endothelin-1 in vivo and in cultured endothelial cells), 1994
• First Prize, Clinical Achievements, PUMC Hospital, Beijing, P.R. China, 1994
• Second Prize, Clinical Achievements, PUMC Hospital, Beijing, P.R. China, 1993

ORIGINAL PUBLICATIONS IN PEER-REVIEWED JOURNALS

1. Zhang FC, Cao W. Fever, rash and diarrhea. Chinese Journal of Pathology. 1987; 16(2): 153-157.
2. Cao W, Li LY, Zhu YJ, Luo WC, ZG He. Fever, cough and pulmonary shadows. Chinese Journal of Tuberculosis and Respiratory Diseases. 1990; 13(5): 309-310.
3. Lu WX and Cao W. Pleural effusion and pulmonary shadows. Chinese Journal of Tuberculosis and Respiratory Diseases. 1991; 14(2): 114-115.
4. Cao W, Luo WC, Guo ZJ, YJ Zhu. Effects of methylene blue on acute hypoxic pulmonary hypertension in anesthetized dogs. National Medical Journal of China. 1992; 72(3): 165-166.
5. Cao W, Luo WC, Guo ZJ, Zhu YJ, XL Liu. Changes of plasma lipoperoxide during acute hypoxia. Basic Medical Sciences & Clinics. 1992; 12(2): 60.
6. Cao W, Luo WC, Guo ZJ, YJ Zhu. Methylene blue inhibits the decrease of the hypoxic pulmonary artery pressure produced by ligustrazine. Chinese Journal of Tuberculosis and Respiratory Diseases. 1993; 16(2): 105.
7. Cao W, Zeng ZP, Zhu YJ, Luo WC, BQ Cai. Inhibition of nitric oxide synthesis increases the secretion of endothelin-1 in vivo and in cultured endothelial cells. Chinese Medical Journal. 1994; 107(11): 822-826.
8. Cao W, Zhu YJ, Luo WC, Cai BQ, SY Xu. Inhibition of endogenous nitric oxide synthesis enhances acute hypoxic pulmonary vasoconstriction. Chinese Journal of Tuberculosis and Respiratory Diseases. 1994; 17(3): 148-151.
9. Cao W, Zhu YJ, Xu KF, Wang J, WC Luo. Pulmonary Nocardia infection. Chinese Journal of Internal Medicine. 1994; 33(10): 663-665.
10. Cao W, Zeng ZP, Luo WC, Zhu YJ, SY Xu. The effect of acute pulmonary alveolar hypoxia on canine plasma endothelin-1 levels. Acta Academinae Medicinae Sinicae. 1994; 16(5): 356-360.
11. Cao W, Luo WC, Guo ZJ, YJ Zhu. Effects of ligustrazine and nitroglycerine on acute hypoxic pulmonary hypertension in mongrel dogs. Acta Academinae Medicinae Sinicae. 1994; 16(2): 79-83.
12. Cao W, Zhu, YJ, Gao YL, WC Luo. A report of two cases with amyloidosis and pleural effusion. Acta Academinae Medicinae Sinicae. 1994; 16(5): 401-402.
13. Cao W, YJ Zhu. A report of one case with acute hypersensitivity pneumonitis induced by ofloxacin. Chinese Journal of Tuberculosis and Respiratory Diseases. 1994; 17(5): 300.
14. Sheng RY, Wang AX, Cao W, Zhu YJ, Y Yuan. Observation on efficacy of rulid in treatment of respiratory tract infections. Chinese Journal of New Drugs. 1994; 3(6): 42-44.
15. Li LY, Zhu YJ, Yu L, et al. The Effect of recombinant granulocyte colony-stimulating factor in treatment of neutropenia caused by chemotherapy. Chinese Journal of New Drugs. 1994; 3(1): 29-32.
16. Cao W, Zeng ZP, Zhu YJ, Luo WC, BQ Cai. Effect of NG-nitro-L-arginine methyl ester on the secretion of endothelin-1 in vivo and in cultured endothelial cells. National Medical Journal of China. 1995; 75(3): 164-166.
17. Cao W, Zhu YJ, Luo WC, Wang ZF, B Yao. Reversal of acute hypoxic pulmonary hypertension with inhalation of nitric oxide. Chinese Journal of Internal Medicine. 1995; 34(1): 9-12.
18. Cao W, Zeng ZP, Zhu YJ, Luo WC, ZF Wang. Effects of L-arginine on acute hypoxic pulmonary hypertension and production of endothelin-1 in vivo and in cultured endothelial cells. Acta Academinae Medicinae Sinicae. 1996; 18(3): 214: 218.
19. Sohn UD, Harnett KM, Cao W, et al. Acute experimental esophagitis activates a second signal transduction pathway in cat smooth muscle from the lower esophageal sphincter. J Pharmacol Exp Ther. 1997; 283(3): 1293-1304.
20. Cao W, Zeng ZP, Zhu YJ, WC Luo. Effects of calcium blockers and calmodulin inhibitors on the secretion of endothelin-1 in cultured endothelial cells. Acta Academinae Medicinae Sinicae. 1997; 19(6): 465-469.
21. Cao W, Zeng ZP, Naruse M, et al. Effects of tetramethylpyrazine, a Chinese medicine, on plasma endothelin-1 levels during acute pulmonary hypoxia in anesthetized dogs. J Cardiovasc Pharmacol. 1998; 31(Suppl 1): S456-S459. doi: 10.1097/00005344-199800001-00130
22. Kim N, Cao W, Song IS, Kim CY, Sohn UD, Biancani P. Leukotriene D4-induced contraction of cat esophageal and lower esophageal sphincter circular smooth muscle. Gastroenterology. 1998; 115(4): 919-928. doi: 10.1016/S0016-5085(98)70264-1
23. Cao W, Pricolo V, Zhang L, Behar J, Biancani P, MT Kirber. Gq-linked NK2 receptors mediate neurally induced contraction of human sigmoid circular smooth muscle. Gastroenterology. 2000; 119: 51-61. doi: 10.1053/gast.2000.8552
24. Cao W, Harnett KM, Chen Q, Jain MK, Behar J, Biancani P. Group I secreted PLA2 (sPLA2) and arachidonic acid metabolites in the maintenance of cat LES tone. Am J Physiology. 1999; 277(3 Pt 1): G585-G598. doi: 10.1053/gast.2000.19581
25. Cao W, Harnett KM, Behar J, Biancani P. Group I Secreted PLA2 in the Maintenance of Human Lower Esophageal Sphincter Tone. Gastroenterology. 2000; 119: 1243-1252. doi: http://dx.doi.org/10.1053/gast.2000.19581
26. Cao W, Chen Q, Sohn UD, et al. Ca++ induced contraction of cat esophageal circular smooth muscle cells. Am J Physiol Cell Physiol. 2001; 280: C980–C992.
27. Sohn UD, Cao W, Tang DC, et al. Myosin light chain kinase dependent and PKC dependent contraction of LES and esophageal smooth muscle. Am J Physiol Gastrointest Liver Physiol. 2001 Aug; 281(2): G467-G478.
28. Vrees MD, Pricolo VE, Potenti FM, Cao W. Abnormal motility in patients with ulcerative colitis: the role of inflammatory cytokines. Archives of Surgery. 2002; 137: 439-445. doi: 10.1001/archsurg.137.4.439.
29. Cao W, Harnett KM, Behar J, Biancani P. PGF2α- induced contraction of cat esophageal and lower esophageal sphincter circular smooth muscle. Am J Physiol Gastrointest Liver Physiol. 2002; 283: G282-G291. doi: 10.1152/ajpgi.00357.2001
30. Cao W, Sohn UD, Behar J, Biancani P, Harnett KM. Mitogen activated protein kinase mediates protein kinase C-dependent contraction of cat esophageal and lower esophageal sphincter circular smooth muscle. Am J Physiol Gastrointest Liver Physiol. 2003; 285: G86-G95.
31. Cao W, Vrees MD, Kirber MT, Fiocchi C, Pricolo VE. Hydrogen peroxide contributes to motor dysfunction in ulcerative colitis. Am J Physiol Gastrointest Liver Physiol. 2004; 286(5): G833-43. doi: 10.1152/ajpgi.00414.2003
32. Cao W, Vrees MD, Potenti FM, Harnett KM, Fiocchi C, Pricolo VE. Interleukin 1beta-induced production of H2O2 contributes to reduced sigmoid colonic circular smooth muscle contractility in ulcerative colitis. J Pharmacol Exp Ther. 2004; 311(1): 60-70. doi: 10.1124/jpet.104.068023
33. Kim N, Cao W, Song IS, et al. Distinct kinases are involved in contraction of cat esophageal and lower esophageal sphincter smooth muscles. Am J Physiol Cell Physiol. 2004; 287(2): C384-C394. doi: 10.1152/ajpcell.00390.2003
34. Cao W, Cheng L, Behar J, Fiocchi C, Biancani P, Harnett KM. Proinflammatory cytokines alter/reduce esophageal circular muscle contraction in experimental cat esophagitis. Am J Physiol Gastrointest Liver Physiol. 2004; 287(6): G1131-G1139. doi: 10.1152/ajpgi.00216.2004
35. Cheng L, Cao W, Behar J, Biancani P, Harnett KM. Inflammation induced changes in arachidonic acid metabolism in cat LES circular muscle. Am J Physiol Gastrointest Liver Physiol. 2005; 288(4): G787-G797. doi: 10.1152/ajpgi.00327.2004
36. Cao W, Harnett KM, Cheng L, Kirber M, Behar J, Biancani P. H2O2, a mediator of esophagitis-induced damage to calcium-release mechanisms in cat lower esophageal sphincter (LES). Am J Physiol Gastrointest Liver Physiol. 2005; 288(6): G1170-G1178. doi: 10.1152/ajpgi.00509.2004
37. Cheng L, Cao W, Fiocchi C, Behar J, Biancani P, Harnett KM. Platelet-activating factor and prostaglandin E2 impair esophageal ACh release in experimental esophagitis. Am J Physiol Gastrointest Liver Physiol. 2005; 289(3): G418-G428. doi: 10.1152/ajpgi.00024.2005
38. Cheng L, Cao W, Fiocchi C, Behar J, Biancani P, Harnett KM. In vitro model of acute esophagitis in the cat. Am J Physiol Gastrointest Liver Physiol. 2005; 289(5): G860-G869. doi: 10.1152/ajpgi.00260.2005
39. Cao W, Fiocchi C, Pricolo VE. Production of interleukin-1 {beta}, hydrogen peroxide, nitric oxide by colonic mucosa decreases sigmoid smooth muscle contractility in ulcerative colitis. Am J Physiol Cell Physiol. 2005; 289(6): C1408-C1416. doi: 10.1152/ajpgi.00260.2005
40. Cheng L, Harnett KM, Cao W, et al. Hydrogen peroxide reduces lower esophageal sphincter tone in human esophagitis. Gastroenterology. 2005; 129(5): 1675-1685. doi: http://dx.doi.org/10.1053/j.gastro.2005.09.008
41. Cheng L, Cao W, Fiocchi C, Behar J, Biancani P, Harnett KM. HCL-induced inflammatory mediators in cat esophageal mucosa and inflammatory mediators in esophageal circular muscle in an in vitro model of esophagitis. Am J Physiol Gastrointest Liver Physiol. 2006; 290(6): G1307-G1317. doi: 10.1152/ajpgi.00576.2005
42. Xiao ZL, Cao W, Biancani P, Behar J. Non-genomic effects of progesterone on the contraction of muscle cells from guinea pig colon. Am J Physiol Gastrointest Liver Physiol. 2006; 290(5): G1008-G1015. doi: 10.1152/ajpgi.00382.2005
43. Cao W, Harnett KM, Pricolo VE. NK2 receptor-mediated spontaneous phasic contractions in normal and ulcerative colitis human sigmoid colon. J Pharmacol Exp Ther. 2006; 317(3): 1349-1355. doi: 10.1124/jpet.105.097030
44. Fu F, Beer D, Behar J, Wands J, Lambeth D, Cao W. cAMP response element binding protein (CREB) is responsible for acid-induced NOX5 expression in Barretts esophageal adenocarcinoma cells. J Biol Chem. 2006; 281(29): 20368-20382. doi: 10.1074/jbc.M603353200
45. Cao W, Cheng L, Behar J, Biancani P, Harnett KM. IL-1 signaling in cat lower esophageal sphincter (LES) circular muscle. Am J Physiol Gastrointest Liver Physiol. 2006; 291(4): G672-G680. doi: 10.1152/ajpgi.00110.2006
46. Cheng L, Cao W, Behar J, Fiocchi C, Biancani P, KM Harnett. Acid induced release of PAF by human esophageal mucosa induces inflammatory mediators in circular smooth muscle. J Pharmacol Exp Ther. 2006; 319(1): 117-126. doi: 10.1124/jpet.106.106104
47. Si J, Fu X, Behar J, et al. NADPH oxidase NOX5-S mediates acid-induced cyclooxygenase-2 expression via activation of NF-kappa B in Barretts esophageal adenocarcinoma cells. J Biol Chem. 2007; 282(22): 16244-16555. doi: 10.1074/jbc.M700297200
48. Si J, Behar J, Wands J, et al. STAT5 mediates platelet-activating factor (PAF)-induced NADPH oxidase NOX5-S expression in barretts esophageal adenocarcinoma cells. Am J Physiol Gastrointest Liver Physiol. 2008; 294(1): G174- G183. doi: 10.1152/ajpgi.00291.2007
49. Cheng L, de la Monte S, Ma J, et al. HCl-activated neural and epithelial vanilloid receptors (TRPV1) in cat esophageal mucosa. Am J Physiol Gastrointest Liver Physiol. 2009; 297(1): G135-G143. doi: 10.1152/ajpgi.90386.2008
50. Hong J, Behar J, Wands J, et al. Role of a novel bile acid receptor TGR5 in the development of esophageal adenocarcinoma. Gut. 2010; 59(2): 170-180. doi: 10.1136/gut.2009.188375
51. Hong J, Behar J, Wands J, et al. Bile acid reflux contributes to development of esophageal adenocarcinoma via activation of phosphatidylinositol-specific phospholipase Cγ2 and NADPH oxidase NOX5-S. Cancer Res. 2010; 70(3): 1247-1255. doi: 10.1158/0008-5472.CAN-09-2774
52. Ma J, Harnett KM, Behar J, Biancani P, Cao W. Signaling in TRPV1 induced platelet activating factor (PAF) in human esophageal epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2010; 298(2): G233-G240. doi: 10.1152/ajpgi.00409.2009
53. Hong J, Resnick M, Behar J, et al. Acid-induced p16 hypermethylation contributes to development of esophageal adenocarcinoma via activation of NADPH oxidase NOX5-S. Am J Physiol Gastrointest Liver Physiol. 2010; 299(3): G697-G706. doi: 10.1152/ajpgi.00186.2010
54. Hong J, Resnick M, Behar J, Wands J, DeLellis RA, Cao W. Role of RAC1 in Regulation of NOX5-S Function in Barretts Esophageal Adenocarcinoma Cells. Am J Physiol Cell Physiol. 2011; 301(2): C413-C420. doi: 10.1152/ajpcell.00027.2011
55. Zhou X, Li D, Resnick M, Behar J, Wands J, Cao W. Signaling in H2O2-induced increase in cell proliferation In Barretts Esophageal Adenocarcinoma Cells. J Pharmacol Exp Ther. 2011; 339(1): 218-227. doi: 10.1124/jpet.111.182352
56. Ma J, Altomare A, Guarino M, et al. HCl-induced and ATP-dependent upregulation of TRPV1 receptor expression and cytokine production by human esophageal epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2012; 303(5): G635-G645. doi: 10.1152/ajpgi.00097.2012
57. Cao W, Tian W, Hong J, et al. Expression of bile acid receptor TGR5 in gastric adenocarcinoma. Am J Physiol Gastrointest Liver Physiol. 2013; 304(4): G322-G327. doi: 10.1152/ajpgi.00263.2012
58. Zhou X, Li D, Resnick M, Wands J, Cao W. NADPH oxidase NOX5-S and NF-κB1 mediate acid-induced microsomal prostaglandin synthase-1 (mPGES1) expression in barretts esophageal adenocarcinoma (EA) cells. Molecular Pharmacology. 2013; 83(5): 978-90. doi: 10.1124/mol.112.083287.
59. Lin YW, Ren LL, Xiong H, et al. Role of STAT3 and Vitamin D Receptor in EZH2-mediated invasion of human colorectal cancer. J Pathol. 2013; 230(3): 277-90. doi: 10.1002/path.4179.
60. Hong J, Li D, Wands J, Souza R, Cao W. Role of NADPH oxidase NOX5-S, NF-κB, DNMT1 in acid-induced p16 hypermethylation in Barretts cells. Am J Physiol Cell Physiol. 2013; 305(10): C1069-C1079. doi: 10.1152/ajpcell.00080.2013
61. Li D, Cao W. Role of Intracellular Calcium and NADPH Oxidase NOX5-S in Acid-Induced DNA Damage In Barretts Esophageal Adenocarcinoma Cells. Am J Physiol Gastrointest Liver Physiol. 2014; 306(10): G863-G872. doi: 10.1152/ajpgi.00321.2013
62. Weng YR, Yu YN, Ren LL, et al. Role of C9orf140 in the promotion of colorectal cancer progression and mechanisms of its upregulation via activation of STAT5, β-catenin and EZH2. Carcinogenesis. 2014; 35(6): 1389-1398. doi: 10.1093/carcin/bgu057
63. Sun T, Du W, Xiong H, Yu YN, et al. TMEFF2 deregulation contributes to gastric carcinogenesis and indicates poor survival outcome. Clin Cancer Res. 2014; doi: 10.1158/1078-0432.CCR-14-0315


Other peer-reviewed publications

1. Cao W, Luo WC. Vascular peptides and pulmonary circulation. GuoWai YiXue Huxi XiTong FenCe. 1992; 12(4): 175-178.
2. Cao W, Luo WC. Implications of angiotensin converting enzyme in serum and bronchial alveolar lavage fluid. Chinese Journal of Internal Medicine. 1992; 31(1): 55-57.
3. Harnett KM, Cao W, Kim N, Sohn UD, Rich H, Behar J , Biancani P. Signal transduction in esophageal and LES circular muscle contraction. Yale J. Biology and Medicine. 1999; 72: 153-168.
4. Harnett KM, Cao W, Biancani P. Signal-transduction pathways that regulate smooth muscle function I. Signal transduction in phasic (esophageal) and tonic (gastroesophageal sphincter) smooth muscles. Am J Physiol Gastrointest Liver Physiol. 2005; 288(3): G407-G416. doi: 10.1152/ajpgi.00398.2004
5. Fang D, Das KM, Cao W, et al. Barretts esophagus: progression to adenocarcinoma and markers. Ann N Y Acad Sci. 2011; 1232: 210-229. doi: 10.1111/j.1749-6632.2011.06053.x
6. Orlando RC, Paterson WG, Harnett KM, et al. Esophageal disease: updated information on inflammation. Ann N Y Acad Sci. 2011; 1232: 369-375. doi: 10.1111/j.1749-6632.2011.06064.x.
7. Cao W. Is acid reflux important in the Progression from Barretts Esophagus to Esophageal Adenocarcinoma? Journal of Gastrointestinal & Digestive System. 2012; 2(2): e108. doi: 10.4172/2161-069X.1000e108

Mohamad A. Mokadem, MD

Diplomate of the American Board of Obesity Medicine
Department of Internal Medicine
Division of Gastroenetrology and Hepatology
University of Iowa Health Care
200 Hawkins Drive, 4570 JCP
Iowa City, IA 52242, USA

BiographyResearch InterestScientific ActivitiesPublications

Dr. Mokadem is native of Lebanon, one the smallest but most dynamic countries in the Middle East. He finished his undergraduate studies as well as his medical degree from the American university of Beirut (AUB) in 2003. He did his initial residency training in Internal Medicine at the AUB-Medical center where he also served as the Medical Chief Resident during 2006-2007. Then, he moved to the United States for advanced training where he did another residency in Internal Medicine at Indiana University in Indianapolis, IN followed by fellowship training in Gastroenterology and Hepatology at the UT Southwestern University (UTSW) in Dallas, TX. During that same period (extending between 2010 and 2014) he also finished post-doctoral fellowship training in obesity and metabolism with a focus on understanding the mechanism behind the beneficial effects of bariatric surgery at the Center for Hypothalamic Research at UTSW under the supervision and guidance of Joel Elmquist DVM, PhD and Vincent Aguirre M.D, Ph.D. Dr. Mokadem was involved in developing a surgical model for gastric bypass in mice to apply to genetic mouse models in order to better comprehend the molecular mechanism underlying that operation. He recently moved to the University of Iowa Health Care to start my career in clinical gastroenterology and my investigational quest to better understand the pathophysiology of obesity as well at the mechanism underlying the most effective therapy available for it at the moment, meaning bariatric surgery.

His research interests include: Studying the mechanism of body weight and metabolic regulation after bariatric surgery in rodents (specifically Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG)). We have developed a reproducible model of RYGB in mice that recapitulates the human effects of RYGB on body weight, body composition, food intake, fecal calories, glucose homeostasis, and lipid homeostasis. We are interested in looking at the outflow messages delivered from the re-arranged gut (post-surgery) into other parts of the body (including the brain, liver, pancreas and fat tissue) communicating the dynamic energy status of luminal tract and exerting changes to rest the host’s energy balance. These messages can be in a form of hormones (like GLP-1 P-YY, CCK etc...) or neuronal signals (like the afferent fibers of the Vagus nerve). This is, of course, important given the implications of understanding the RYGB mechanisms on developing less-invasive alternative therapies for weight loss, diabetes, and other related metabolic conditions.

PROFESSIONAL SOCIETIES:

• (2003-Present): American College of Physicians
• (2010-Present): American Gastroenterology Association
• (2010-Present): American Society for Gastrointestinal Endoscopy
• (2012-Present): The Obesity Society
• (2012-Present): The American Society for Metabolic and Bariatric Surgery


AWARDS AND HONORS:

• (2008-2009): ACP Research Abstract competition Award, Indiana Chapter
• (2008-2009): Winner of Test your Knowledge competition at ACP meeting, Indiana Chapter

1. Li H, Chan L, Bartuzi P, et al. Copper Metabolism Domain-containing 1 Represses Genes that Promote Inflammation and Protects Mice From Colitis and Colitis-associated Cancer. Gastroenterology. 2014. doi: 10.1053/j.gastro.2014.04.007
2. Mokadem M, Zechner JF, Margolskee RF, Drucker DJ, Aguirre V. Effects of Roux-en-Y gastric bypass on energy and glucose homeostasis are preserved in two mouse models of functional glucagon-like peptide-1 deficiency. Mol Metab. 2013; 3(2): 191-201. doi: 10.1016/j.molmet.2013.11.010
3. Barada K, Bitar A, Mokadem MA, Hashash JG, Green P. Celiac disease in Middle Eastern and North African countries: a new burden? World J Gastroenterol. 2010; 16(12): 1449-1457. doi: 10.3748/wjg.v16.i12.1449.
4. Khashab M, Mokadem M, DeWitt J, et al. Endoscopic ultrasound-guided fine-needle aspiration with or without flow cytometry for the diagnosis of primary pancreatic lymphoma - a case series. Endoscopy. 2010; 42(3): 228-231. doi: 10.1055/s-0029-1243859

Nissar A. Darmani, PhD

Professor of Pharmacology
Associate Dean for Basic Medical Sciences and Research
Chair, Basic Medical Sciences
College of Osteopathic Medicine of the Pacific
Western University of Health Sciences
309 E. Second Street
Pomona, California, CA 91766-1854, USA

BiographyResearch InterestScientific ActivitiesPublications
EDUCATION

• Ph.D., Neuropharmacology, University of Wales, UWIST, UK, 1988
• M.S., Applied Pharmacology, University of Wales, UWIST, UK, 1984
• Medical Scientific Officer, Immunohematology Center, Cambridge, UK, 1979-1983
• B.S., Honors: Pharmacology & Biochemistry, Leeds University, England, UK, 1979


EDUCATION EXPERIENCE

• Postdoctoral Fellow, Neuropsychopharmacology, Department of Pharmacology, Medical College of Virginia, 1988-1991


TEACHING EXPERIENCE

• Associate Dean of BMS and Research, Western University of Health Sciences, COMP, 2011-present
• Assistant Dean of BMS and Research, Western University of Health Sciences, COMP, 2008-2011
• Chair, Department of Basic Medical Sciences, Western University of Health Sciences, COMP 2005-present
• Professor, Department of Pharmacology, Kirksville College of Osteopathic Medicine, Kirksville, MO, 2000-2005
• Associate Professor, Department of Pharmacology, Kirksville College of Osteopathic Medicine, Kirksville, MO, 1995-2000
• Assistant Professor, Department of Pharmacology, Kirksville College of Osteopathic Medicine, Kirksville, MO, 1991-1995
• Research Assistant Professor, Department of Pharmacology, Medical College of Virginia, 1991

His research interests include: Developmental effects of drugs of abuse on the newborn, Serotonergic mechanisms of cocaines actions, Mode of action of antidepressant drugs, Adaptive mechanisms of serotonergic 5-HT2 receptor functions, The role of delta-9 -THC and synthetic cannabinoids on chemotherapy- and radiotherapy-induced vomiting. His laboratory had the first opportunity to demonstrate the mechanisms of antiemetic actions of marijuana, Role of 5-HT3-, Dopamine D2/3-, Lekotriene CysLT1- and NK1- receptors in emesis and application of their antagonists as antiemetics.
Another of his research interests involves the role of osteopathic manipulative medicine on the blood levels of endogenous cannabinoid-like compounds and other pain markers in patients with back pain. He had been successful in obtaining several million dollars of research grants from numerous funding agencies including the Pharmaceutical industry, the National Institute of Drug Abuse, the National Institute of Cancer, the Department of Defense and the Environmental Protection Agency.

MEMBERSHIP IN PROFESSIONAL SOCIETIES

• (1991-present)- Society for Neuroscience
• (1994-present)- Afghan Physicians Association in America
• (1997-present)- ASPET and FASEB
• (2000-present)- International Cannabinoid Research Society
• (2013-present)- Member of the Editorial board of the European J. Pharmacology


HONORS

• 1984 - External Examiners Award for best M.S. Thesis
• 1987 - SRC (U.K.) Travel Award for Israel for the 6th International Catecholamine Symposium
• 1994 - Young Investigator Travel Award for IUPHAR
• 1994 - Member of the Editorial Board of APIA
• 1994 - Member of the Editorial Board of SRC Book Co.
• 1995 - Included in Whos Who in Science & Engineering
• 1996 - Included in Whos Who in Medicine & Health Care
• 1997 - Included in 2000 Outstanding People of the 20th Century by IBC
• 1999 - Sigma Xi Researcher of the Year
• 2005 - American Osteopathic Association- Korr Research award


RESEARCH

Dr. Darmani is recognized as a world leader in the area of emesis (vomiting) research with more than 50 publications in this research area alone. Vomiting is a debilitating condition caused by diverse diseases, many drugs including chemotherapeutics, bacterial and viral toxins. The available antiemetic drus are useful but there is a profound need for new agents that completely prevent vomiting. The often used laboratory animals such as mice and rats cannot vomit, while larger vomit competent species such as dogs, cats and ferrets are often kept as family pets and therefore the general public frown on their use in the laboratory. In 1998 Darmani introduced the smallest mammal, the least shrew (Cryptotisparva, adults weighing 3-6 grams each), that can vomit in response to chemotherapeutics and other emetogens. Since then his laboratory has fully characterized new as well as most of the known endogenous emetic neurotransmitter receptor systems in this vomit competent species. Through the years His research has been funded by the National Institute of Health in the USA as well as drug industry.
Although it was known in mid 1970s that marijuana can suppress vomiting caused by anticancer drugs in patients, in 2001 Darmani was the first researcher to identify that stimulation of the cannabinoid CB1 receptor is responsible for the antiemetic activity of the psychoactive component of the marijuana plant.
In 2009 in a seminal review in chemical reviews, Darmani challenged the well-established simple dogma of the neurotransmitter basis of chemotherapy-induced immediate and delayed phases of vomiting, and provided more a complex, multi-transmitter-mediated, gut-brain interactive circuits being involved in both phases of chemotherapy-induced vomiting.
In 2010 His laboratory identified a new class of endogenous chemicals, the Leukotrienes (induce asthma), cause profound vomiting, that can be specifically blocked by the clinically-used anti-asthmatic drug pranlukast.
In 2011 Darmani demonstrated that the antagonists (tropisetron and CP99994, respectively) of the major emetic transmitters (serotonin and substance P) in chemotherapy-induced vomiting, not only prevent vomiting when administered by themselves, but when combined they possess additive antiemetic efficacy when vomiting is caused by either serotonergic (e.g. 2-methylserotonin) or substance P-like (GR73632) agonists.
In 2014 His Laboratory introduced the clinically used antihypertensive L-type calcium channel blockers nifedipine and amlodipine as broad-spectrum anti-vomiting agents with potential clinical use against diverse causes of vomiting.
In 2014, the editor of European journal of Pharmacology invited Professor Darmani to guest edit and lead an international group of basic scientists and physicians to write a whole volume dedicated to “New vistas in the pharmacology and neurochemistry of diverse causes of nausea and vomiting” (see attached cover and preface documents).

1. Zhong W, Hutchinson TE, Chebolu S, Darmani NA. Serotonin 5-HT3 receptor-mediated vomiting occurs via the activation of Ca2+/CaMKII-dependent ERK1/2 signaling in the least shrew (Cryptotis parva). PLOS ONE. 2014; 9(8): e104718. doi: 10.1371/journal.pone.0104718
2. Al-Tikriti MS, Khamas W, Chebolu S, Darmani NA. Histopathology, immunohistochemistry of the lower esophageal sphincter (LES) of the least shrew (Cryptotis parva). Cells Tissues Organs. 2014. doi: 10.1159/000359999
3. Zhong W, Chebolu S, Darmani NA. Broad-spectrum antiemetic potential of the L-type calcium channel blocker amlodipine in the least shrew (Cryptotis parva). Pharmacol Biochem Behav. 2014; 120: 124-132. doi: 10.1016/j.pbb.2014.03.005
4. Darmani NA. Preface: New vistas in the pharmacology and neurochemistry of diverse causes of nausea and vomiting. Eur J Phatmacol. 2014; 722: 1. doi: 10.1016/j.ejphar.2013.12.012
5. Sharkey KA, Darmani NA, Parker LA. Regulation of nausea and vomiting by cannabinoids and the endicannabinoid system. Eur J Pharmacol. 722: 134-146. doi: . 10.1016/j.ejphar.2013.09.068
6. Darmani NA, Zhong W, Chebolu S, Vaezi M, Alkam T. Broad-spectrum antiemetic potential of the L-type calcium channel antagonist nifedipine and evidence for its additive antiemetic interaction with the 5-HT3 receptor antagonist palonosetron in the least shrew (Cryptotis parva). Eur J Pharmacol. 2014; 722: 2-22. doi: 10.1016/j.ejphar.2013.08.052
7. Alkam T, Chebolu S, Darmani NA. Cyclophosphamide causes activation of protein kinase A (PKA) in the brainstem of vomiting least shrews (Cryptotis parva). Eur J Pharmacol. 2014; 722: 156-164. doi: 10.1016/j.ejphar.2013.09.080
8. Darmani NA, Chebolu S, Zhong W, Trinh C, McClanahan B, Brar RS. Additive antiemetic efficacy of low-doses of the cannabinoid CB1/2 receptor agonist 9-THC with ultralow-doses of the vanilloid TRPV1 receptor agonist resiniferatoxin in the least shrew (Cryptotis parva). Eur J Pharmacol. 2014; 722: 147-155. doi: 10.1016/j.ejphar.2013.08.051
9. Darmani NA. New vistas in the pathophysiology of vomiting. Family Medicine Medical Science Res. 2013; 2: 1. doi: 10.4172/2327-4972.1000e105
10. Darmani NA, Dey D, Chebolu S, Amos BK, Pal R. Cisplatin causes over-expression of neurokinin NK1 receptors and increases ERK1/2- and PKA-phosphorylation during peak immediate- and delayed-phase emesis in the least shrew (Cryptotis parva) brainstem. Eur J Pharmacol. 2013; 698: 161-169. doi: 10.1016/j.ejphar.2012.09.008
11. Al-Tikriti MS, Khamas W, Chebolu S, Darmani NA. Distribition of serotonin-immunoreactive chromaffin cells in the gastrointestinal tract of the least shrew (Cryptotis parva). Int J Morphology. 2012; 30: 916-923.
12. Darmani NA, Chebolu S, Amos B, Alkam T. Synergistic antiemetic interactions between serotonergic 5-HT3 and tachykininergic NK1- receptor antagonists in the least shrew. Pharmacol Biochem Behav. 2011; 99: 573-579. doi: 10.1016/j.pbb.2011.05.025
13. Darmani NA. Cannabinoid-induced hyperemesis: a conundrum- from clinical recognition to basic science mechanisms. Pharmaceuticals. 2010; 3: 2163-2177. doi: 10.3390/ph3072163
14. Darmani NA. Mechanisms of broad-spectrum antiemetic efficacy of cannabinoids against chemotherapy-induced acute and delayed vomiting. Pharmaceuticals. 2010; 3: 2930-2955. doi: 10.3390/ph3092930
15. Hubbard S, Darmani NA, Thrush GR, et al. Zebrafish encoded 3-O-sulfotransferase-3 isoform mediates HSV-1 entry and spread. Zebrafish. 2010; 7: 181-187. doi: 10.1089/zeb.2009.0621.
16. King KS, Darmani NA, Adams KT, Pacak K. Exercise-induced nausea and vomiting: Another sign of pheochromocytoma and paraganglioma. Endocrine. 2010; 37: 403-407. doi: 10.1007/s12020-010-9319-3
17. Tiwari V, Darmani NA, Yue BYJT, Shukla D. In vitro antiviral activity of neem (Azardirachta indica L.) bark extract against herpes simplex virus type-1 infection. Phtotherapy Res. 2010; 24: 1132-1140. doi: 10.1002/ptr.3085.
18. Chebolu S, Wang Y, Ray AP, Darmani NA. Pranlukast prevents Cysteinyl Leukotriene-induced Vomiting in the Least Shrew (Cryptotis parva). Eur J Pharmacol. 2010; 628: 195-201. doi: 10.1016/j.ejphar.2009.11.030
19. Dey D, Abed J, Ray AP and Darmani NA. Differential temporal changes in brain and gut substance P mRNA expression throughout the time course of cisplatin-induced vomiting in the least shrew (Cryptotis parva). Brain Res. 2010; 1310: 103-112. doi: 10.1016/j.brainres.2009.11.005
20. Tiwari V, Darmani NA, Thrush GR, Shukla D. An unusual dependence of human herpesvirus 8 glycoproteins induced cell-to-cell fusion on heparin sulfate. Biochem Biophys Commun. 2009; 390: 382-387. doi: 10.1016/j.bbrc.2009.08.174
21. Ray AP, Chebolu S, Darmani NA. Selective agonists induce emesis and Fos expression in the brainstem and and enteric nervous system of the least shrew (cryptotis parva). Pharmacol Biochem Behav. 2009; 94: 211-218.
22. Darmani NA, Ray AP. Evidence for a re-evaluation of the neurochemical and anatomical bases of chemotherapy-induced vomiting. Chemical Rev. 2009; 109: 3158-3199. doi: 10.1021/cr900117p.
23. Ray AP, Griggs L, Chebolu S, Ramirez J, Darmani NA. Ablation of least shrew central neurokinin NK1 receptors reduces GR73632-induced vomiting. Behav Neuroscience. 2009; 123: 701-706. doi: 10.1037/a0015733.
24. Darmani NA, Crim JL, Janoyan JJ, Abed J, Ramirez J. A re-evaluation of the neurotransmitter basis of chemotherapy-induced immediate and delayed vomiting: evidence from the least shrew. Brain Research. 2009; 1248: 40-58. doi: 10.1016/j.brainres.2008.10.063
25. Wang Y, Ray Ap, McClanahan BA, Darmani NA. The antiemetic interaction of Δ9-Tetrahydrocannabinol when combined with tropisetron or dexamethasone in the least shrew. Pharmacol Biochem Behav. 2009; 91: 367-373. doi: 10.1016/j.pbb.2008.08.008
26. Ray AP, Griggs L, Darmani NA. Δ9-Tetrahydrocannabinol suppresses vomiting behavior and Fos expression in both acute and delayed phases of cisplatin-induced emesis in the least shrew. Behavioral Brain Res. 2009; 196: 30-36. doi: 10.1016/j.bbr.2008.07.028
27. Darmani NA, Wang Y, Abed J, Ray AP, Thrush GR, Ramirez J. Utilization of the least shrew as a rapid and selective screening model for the antiemetic potential and brain penetration of substance P and NK1 receptor antagonists. Brain Res. 2008; 1214: 58-72. doi: 10.1016/j.brainres.2008.03.077
28. Degenhardt BF, Darmani NA, Towns LC, et al. Osteopathic manipulation alters pain biomarkers in blood products of people with chronic low back pain. J American Osteopathic Association. 2007; 107: 387-400.
29. Ray AP, Darmani NA. A histologically-derived stereotaxic atlas and substance P immunohistochemistry in the Brain of the Least Shrew (Cryptotis Parva) support its role as model organism for emesis research. Brain Res. 2007; 1156: 99-111. doi: 10.1016/j.brainres.2007.04.061
30. Darmani NA, Janoyan JJ, Crim JL, Ramirez J. Receptor mechanism and antiemetic activity of structurally-diverse cannabinoids against radiation-induced emesis in the least shrew. Eur J Pharmacol Eur J Pharmacol. 2007; 563: 187-196. doi: 10.1016/j.ejphar.2007.01.093
31. Darmani NA, McClanahan BA, Trinh C, Petrosino S, Valenti M, Di Marzo V. Cisplatin increases brain 2-arachidonoylglycerol (2-AG) and concomitantly reduces intestinal 2-AG and anand amide levels in the least shrew. Neuropharmacology. 2005; 49: 502-513. doi: 10.1016/j.neuropharm.2005.04.007
32. Darmani NA, Izzo AA, Degenhardt B, et al. Implication of the cannabimimetic mediator, palmitoylethanolamide, in inflammatory or neuropathic conditions: A review of the available pre-clinical findings and first clinical data. Neuropharmacology. 2005; 48: 1154-1163.
33. Mock O, Casteel S, Darmani NA, et al. 1, 3-dinitrobenzene toxicity in the least shrew, Cryptotis parva. Environmental Toxicology and Chemistry. 2005; 24: 2519-2525. doi: 10.1897/04-676R.1
34. Darmani NA, Crim JL. Delta-9-tetrahydrocannabinol prevents emesis more potently than enhanced locomotor activity produced by chemically diverse dopamine D2/D3 receptor agonists in the least shrew. (Cryptotis parva) Pharmacol Biochem Behav. 2005; 80: 35-44.
35. Darmani NA, Johnson JC. Central and peripheral mechanisms contribute to the antiemetic actions of Δ9-THC against 5-hydroxytryptophan-induced emesis. Eur J Pharmacol. 2004; 488: 201-212.
36. Darmani NA, Janoyan JJ, Kumar N, Crim JL. Behaviorally active doses of the CB1 receptor antagonist SR141716A increase brain serotonin and dopamine levels and turnover. Pharmacol Biochem Behav. 2003; 75: 777-787. doi: 10.1016/S0091-3057(03)00150-3
37. Darmani NA, Sim-Selly LJ, Martin BR, et al. Antiemetic and motor depressive actions of CP55, 940: Cannabinoid CB1 receptor characterization, distribution and G-protein activation. Eur J Pharmacol. 2003; 459: 83-95. doi: 10.1016/S0014-2999(02)02815-7
38. Darmani NA. The potent emetogenic effects of the endocannabinoid, 2-AG (2-arachidonoylglycerol) are blocked by Δ9-tetrahydrocannabinol and other cannabinoids. J Pharmacol Exp Therap. 2002; 300: 34-42. doi: 10.1124/jpet.300.1.34
39. Janoyan J, Crim J, Darmani NA. Antagonism of SR 141716A-induced head-twitch and ear-scratch responses in mice by Δ9-THC and other cannabinoids. Pharmacol Biochem Behav. 2002; 71: 155-162. doi: 10.1016/S0091-3057(01)00647-5
40. Mock O, Casteel S, Darmani NA, Shaddy J, Besch-Williford C, Towns L. Anatomic and physiologic reference values in least shrews. Cryptotis parva J Comparative Medicine. 2001; 51: 534-537.
41. Darmani NA. The cannabinoid antagonist/inverse agonist SR 141716A reverses the antiemetic and motor depressant action of WIN 55, 212-2 in the least shrew. Eur J Pharmacol. 2001; 430: 49-58.
42. Tizabi Y, Russel LT, Jhonson M, Darmani NA. Nicotine attenuates DOI-induced head-twitch response in mice. Implications for Tourette Syndrome. Progress Neuro-Psychopharmacology and Biological Psychiatry. 2001; 25: 1445-1457. doi: :10.1016/S0278-5846(01)00194-4
43. Darmani NA. Delta-9-tetrahydrocannabinol differentially suppresses cisplatin-induced emesis and indeces of motor function via cannabinoid CB1 receptors in the least shrew. Pharmacol Biochem Behav. 2001; 69: 239-249. doi: 10.1016/S0091-3057(01)00531-7
44. Darmani NA. Cannabinoids of diverse structure inhibit two DOI-induced 5-HT2A receptor mediated behaviors in mice. Pharmacol Biochem Behav 68: 311-317. doi: 10.1016/S0091-3057(00)00477-9
45. Darmani NA. Δ9-Tetrahydrocannabinol and synthetic cannabinoids prevent emesis produced by the cannabinoid CB1 receptor antagonist/inverse agonist SR 141716A. Neuropsycho pharmacology. 2001; 24: 198-203. doi: 10.1016/S0893-133X(00)00197-4
46. Dukat M, Young R, Darmani NA, Ahmad B, Glennon RA. The 5-HT3 agent N-(3-chlorophenyl) guanidine (MD-354) serves as a discriminative stimulus in rats and displays partial agonist character in a shrew emesis model. Psychopharmacology 2000; 150: 200-207.
47. Darmani NA, Pandya DK. Involvement of other neurotransmitters in behaviors induced by the selective cannabinoid CB1 receptor antagonist/inverse agonist SR 141716A in naive mice. J Neural Trans. 2000; 107: 931-945.
48. Darmani NA, Ahmad B. Early postnatal cocaine exposure in mice causes sequential, dose-dependent, enduring but reversible supersensitivity in 5-HT2A receptor-mediated function during development. Neurotoxicol Teratol. 2000; 22: 61-69. doi: 10.1016/S0892-0362(99)00054-9
49. Darmani NA, Zhao W, Ahmad B. The role of D2 and D3 dopamine receptors in the mediation of emesis in Cryptotis parva (the least shrew ). J Neural Trans.1999; 106: 1045-1061. doi: 10.1007/s007020050222
50. Cox JL, Sexton PS, Green TJ, Darmani NA. Inhibition of B 16 melanoma metastasis by overexpression of the cysteine proteinase inhibitor cystatin C. Melanoma Res.1999; 9: 369-374. doi: 10.1097/00008390-199908000-00005
51. Darmani NA, Ahmad B. Long term sequential determination of behavioral ontogeny of 5-HT1A- and 5-HT2-receptor functions in the rat. J Pharmacol Exp Therap.1999; 288: 247-253.
52. Darmani NA. Serotonin 5-HT3 receptor antagonists prevent cisplatin-induced emesis in Cryptotis parva: a new experimental model of emesis. J Neural Trans.1998; 105: 1143-1154. doi: 10.1007/s007020050118
53. Darmani NA, Zhao W. Production of serotonin syndrome by 8-OH DPAT in Cryptotis parva. Physiol Behav.1998; 65: 327-331. doi: 10.1016/S0031-9384(98)00174-7
54. Darmani NA. The silent and selective 5-HT1A antagonist, WAY 100635, produces via an indirect mechanism, a 5-HT2A receptor-mediated behaviour in mice during the day but not at night. J Neural Trans.1998; 105: 635-643.
55. Darmani NA. Cocaine and selective monoamine uptake blockers (sertraline, nisoxetine and GBR 12935) prevent the d-fenfluramine-induced head-twitch response in mice. Pharmacol Biochem Behav.1998; 60: 83-90. doi: 10.1016/S0091-3057(97)00548-0
56. Darmani NA, Shaddy J, Elder EJ. Prolonged deficits in presynaptic serotonin function following withdrawal from chronic cocaine exposure as revealed by 5-HTP-induced head-twitch response in mice. J Neural Trans. 1997; 104: 1229-1247. doi: 10.1007/BF01294723
57. Darmani NA. Deficits in d-fenfluramine-sensitive pool of brain 5-HT following withdrawal from chronic cocaine exposure. Life Sciences. 1997; 61: 2575-2582. doi: 10.1016/S0024-3205(97)01012-6
58. Young R, Darmani NA, Elder EL, Dumas D, Glennon RA. Clobenzorax: Evidence for amphetamine-like behavior. Pharmacol Biochem Behav. 1997; 56: 311-316. doi: 10.1016/S0091-3057(96)00329-2
59. Darmani NA. Withdrawal from chronic cocaine administration causes prolonged deficits in L-tryptophan-induced head-twitch response in mice. Life Sci. 1997; 61: 1147-1158. doi: 10.1016/S0024-3205(97)00647-4
60. Malmusi L, Dukat M, Young R, et al. 1, 2, 3, 4-Tetrahydroisoquinoline anologs of phenylalkylamine designer drug MDMA. Med Chem Res. 1996; 6: 412-426.
61. Malmusi L, Dukat M, Young R, et al. 1, 2, 3, 4-Tetrahydroisoquinoline anologs of phenylalkylamine stimulants and hallucinogens. Med Chem Res. 1996; 6: 400-411.
62. Darmani NA. Differential potentiation of L-tryptophan-induced head-twitch response in mice by cocaine and sertraline. Life Sciences. 1996;59: 1109-1119. doi: 10.1016/0024-3205(96)00428-6
63. Darmani NA. Shaddy J, Gerdes CF. Differential ontogenic regulation of three DOI-induced behaviours in mice. Physiol Behav. 1996; 60: 1495-1500.
64. Darmani NA, Reeves SL. The stimulatory and inhibitory components of cocaines actions on the 5-HTP-induced 5-HT2A-receptor function. Pharmacol Biochem Behav. 1996; 55: 387-396. doi: 10.1016/S0091-3057(96)00108-6
65. Darmani NA, Reeves SL. The mechanism by which the silent and selective 5-HT1A receptor antagonist S-(-)UH 301 produces the 5-HT2A receptor-mediated head-twitch response in mice. Pharmacol Biochem Behav. 1996; 55: 1-10. doi: 10.1016/0091-3057(96)00072-X
66. Onaivi ES, Bishop-Robinson C, Darmani NA, Sand ers-Bush E. Behavioral effects of (±)-1-(2, 5-dimethoxy-4-iodphenyl)-2-aminopropane, (DOI) in the elevated plus-maze test. Life Sci. 1995; 57: 2455-2466. doi: 10.1016/0024-3205(95)02242-9
67. Darmani NA. Avicenna: "The prince of physicians and a giant in pharmacology ". JIMA. 1995; 27: 78-81.
68. Darmani NA, Gerdes CF. Temporal differential adaptation of head-twitch and ear-scratch responses following administration of challenge doses of DOI. Pharmacol Biochem Behav. 1995; 50(4): 545-550. doi: 10.1016/0091-3057(94)00340-8
69. Darmani NA. The effects of acute cocaine administration on the DOI-induced head-twitch response in reserpinized mice. Pharmacol Biochem Behav. 1994; 49: 229-232. doi: 10.1016/0091-3057(94)90481-2
70. Darmani NA, Mock O, Towns L, Gerdes C. The head-twitch response in the least shrew (Cryptotis parva) is a 5-HT2- and not a 5-HT1C-mediated phenomenon. Pharmacol Biochem Behav. 1994; 48: 383-396. doi: 10.1016/0091-3057(94)90542-8
71. Darmani NA. The role of the inhibitory adrenergic α2 and serotonergic 5-HT1A components of cocaines actions on the DOI-induced head-twitch response in 5-HT2-receptor supersensitive mice. Pharmacol Biochem Behav. 1993; 45: 269-274. doi: 10.1016/0091-3057(93)90238-O
72. Darmani NA. Further evidence for enigmas in adaptation mechanisms for the DOI-induced behaviors. Pharmacol Biochem Behav. 1992; 43: 765-770. doi: 10.1016/0091-3057(92)90406-6
73. Darmani NA, Schnoll SH, Pand ey U, Martin BR. Chronic prenatal methadone exposure alters central opiate u-receptor affinity in both fetal and maternal brain homogenates. Neurotoxicol and Teratol. 1992; 14: 265-271. doi: 10.1016/0892-0362(92)90006-V
74. Darmani NA, Martin BR, Glennon RA. Behavioral evidence for differential adaptation of the serotonergic system following acute and chronic treatment with (±)-1-(2, 5-Dimethoxy-4-lodophenyl)-2-Aminopropane (DOI) or ketanscerin. J Pharmacol Exp Therap. 1992; 262: 692-698.
75. Darmani NA, Martin BR, Glennon RA. Repeated administration of low doses of cocaine enhances the sensitivity of 5-HT2-receptor function. Pharmacol Biochem Behav. 1992; 41: 519-527. doi: 10.1016/0091-3057(92)90367-O
76. Glennon RA, Darmani NA, Martin BR. Multiple populations of serotonin receptors may modulate the behavioral effects of serotonergic agents. Life Sciences. 1991; 48: 2493-2498. doi: 10.1016/0024-3205(91)90603-9
77. Darmani NA, Saady J, Schnoll SH, Martin BR. Demonstration of physical dependence following chronic continuous methadone delivery via osmotic minipumps in pregnant rats. Neurotoxicol and Teratol. 1991; 13: 627-629.
78. Darmani NA, Sewell RDE, Nicholls RJ. Acute effects of beclamide on brain regional monoamine steady state concentrations and radioligand binding. J Pharm Pharmacol. 1991; 43: 425-429.
79. Darmani NA, Schnoll SH, Fuchs B, Martin BR. Does chronic prenatal methadone exposure affect B-receptor subtypes in placental, fetal and maternal brain homogenates. Neurotox Teratol. 1991; 13: 43-48.
80. Darmani NA, Martin BR, Pandey U, Glennon RA. Inhibition of 5-HT2-receptor mediated head-twitch response by cocaine via indirect stimulation of adrenergic α2 and serotonergic 5-HT1A receptors. Pharmacol Biochem Behav. 1991; 38: 353-357. doi: 10.1016/0091-3057(91)90290-I
81. Darmani NA, Martin BR, Glennon RA. Withdrawal from chronic treatment with (±)-DOI causes supersensitivity to 5-HT2 receptor induced head-twitch behaviour in mice. Eur J Pharmacol. 1990; 186: 115-118. doi: 10.1016/0014-2999(90)94066-7
82. Darmani NA, Martin BR, Pandey U, Glennon RA. Pharmacological characterization of ear-scratch response in mice as a behavioral model for selective 5-HT2 receptor agonists and evidence for 5-HT1B- and 5-HT2-receptor interaction. Pharmacol Biochem Behav. 1990; 37: 95-99. doi: 10.1016/0091-3057(90)90047-L
83. Darmani NA, Martin BR, Pandey U, Glennon RA. Do Functional relationships exist between 5-HT1A and 5-HT2 receptors. Pharmacol Biochem Behav. 1990; 36: 901-906. doi: 10.1016/0091-3057(90)90098-3
84. Darmani NA, Hadfield MG, Carter WH, Martin BR. Acute and chronic effects of cocaine on isolation-induced aggression. Psychopharmacology. 1990; 102: 37-40. doi: 10.1007/BF02245741
85. Darmani NA, Sewell RDE, Nicholls RJ. Comparison of the inhibitory action of aminobeclamide and beclamide on isolation-induced socially offensive behavior. J Pharm Pharmacol. 1990; 42: 447-449.
86. Darmani NA, Sewell RDE, Nicholls RJ. Dopamine mediated behavior following chronic treatment with B-HT 920. J Pharm Pharmacol. 1988; 40: 523-524. doi: 10.1111/j.2042-7158.1988.tb05294.x
87. Darmani NA, Sewell RDE, Nicholls RJ. Effects of beclamide on isolation-induced aggression and locomotor activity in mice. J Pharm Pharmacol. 1988; 40: 891-893.
88. Darmani NA, Broadley KJ. Actions and interactions of adenosine, theophylline and emprophylline on the guinea-pig spirally cut trachea. Eur J Pharmacol. 1986; 125: 353-362. doi: 10.1016/0014-2999(86)90791-0
89. Darmani NA, Zhong W. Role of calcium in vomiting: revelations from the least shrew model of emesis. Gastro Open J. 2015; 1(5): 119-128. doi: 10.17140/GOJ-1-121