Editorial Board


Dentistry - Open Journal

Mohammed Mustafa, BDS, MDS, FPFA, FADI (USA), FICD


Assistant Professor and Head of Endodontic Division
Department of Conservative Dental Sciences, College of Dentistry
Prince Sattam bin AbdulAziz University, P.O.BOX: 153
AlKharj - 11942, Kingdom of Saudi Arabia.

BiographyResearch InterestScientific ActivitiesPublications

Mohammed Mustafa, is an Assistant Professor and Head of Endodontic Division, Department of Conservative Dental Sciences, and also holds an additional responsibility of being College Coordinator (Quality & Development), College of Dentistry, Prince Sattam Bin AbdulAziz University, AlKharj, Saudi Arabia. Dr. Mustafa has more than 20 scientific papers published in well recognized and peer reviewed journals. He is also in editorial board for some national and international reputed journals. Dr. Mustafa holds a BDS (Bachelor of Dental Surgery) and MDS (Master of Dental Surgery) with specialization in Conservative Dentistry and Endodontics. He has also been honored with fellowships i.e. Fellowships in Pierre Fauchard Academy (FPFA), Fellowship in Academy of Dentistry International (FADI, USA) and also Fellowship in International College of Dentists (FICD).

His research interest inclides Endodontics; Restorative & Esthetic Dentistry; Oral microbiology; Oral and Dental Public Health.

1. Restoring esthetics by interdisciplinary approach. EC Dental Science. 2016; 6(5): 1395-1402. 2. Comparison of the solubility of conventional luting cements with that of the polyacid modified composite luting cement and resin modified glass ionomer cemen. J Contemp Dent Pract. 2016; 17(12): 1016-1021. 3. Mustafa M. Historical perspective in surgical endodontics. Adv Dent Oral Health. 2016; 3(5): 55603. doi: 10.19080/ADOH.2016.02.555603
4. Mustafa M. Endodontic surgery-A challenge to an endodontist. J Orthod Endod. 2016; 2(4): 1-3. doi: 10.21767/2469-2980.100031
5. Mustafa M, AlJeaidi Z, AlAajam WH, Dafaalla Mohammed KA. The study of caries prevalence in miswak and non-miswak users: A prospective study. J Contemp Dent Pract. 2016; 17(11): 926-929. doi: 10.5005/jp-journals-10024-1955
6. Mustafa M, Mahmood S, Al Jeaidi ZA. An analysis of root canal treatments in student clinics of a saudi university. J Pak Dent Assoc. 2016; 25(2): 67-70. Web site. http://jpda.com.pk/wp-content/uploads/2016/11/7-Shahid-Mahmood.pdf
7. Mustafa M. Antibacterial efficacy of neem (Azadirachta indica) extract against enterococcus faecalis: An in vitro study. J Contemp Dent Pract. 2016; 17(10): 791-794. doi: 10.5005/jp-journals-10024-1932
8. Microscope in endodontics–you can treat better what you see and you won’t what you don’t. EC Dental Science ECO. 2016; 1: 38-40.
9. Daokar S, Siddiqui S, AlJeaidi ZA, Mustafa M, Mapari PS, Nadeem F. Assessment of oxidative stress induced by various restorative materials: An in vivo biochemical study. J Int Oral Health. 2016; 8(6): 670-74. doi: 10.2047/jioh-08-06-05
10. Mahmoud AS, Dafaalla KA, Ustad F, Mustafa M. Medical and dental rehabilitation of esthetic and biologicallly compromised case. J Int Oral Health. 2016; 8(3): 38-40. doi: 10.2047/jioh-08-03-19
11. Mustafa M. Knowledge, attitude and practice of general dentists towards sterilization of endodontic files: A cross-sectional study. Indian J Science Technology. 2016; 9(11): 1-4. doi: 10.17485/ijst/2016/v9i11/81086
12. A note on endodontic mishap. American J Advances Med Sci. 2015; 3(4): 21-23.
13. Contemporary management of a clinical case by multidisciplinary approach–a case report. Oral Health Dent Manag. 2015; 14(6): 438-44.
14. Knowledge, attitude and practice of medical students towards hepatitis B infection. American J Advances Med Scie. 2015; 3(3): 34-38.
15. Management of an endodontic-periodontal lesion of a maxillary lateral incisor with palatoradicular groove: A case report. Saudi Endodontic J. 2014; 4(2); 83-86.
16. Evaluating the efficiency of operating microscope in detecting and negotiating the second mesiobuccal canal in maxillary first molars: An in-vitro study. Egyptian Dental J. 2013; 59(2); 01-11.
17. Microleakage evaluation in restorations using different resin composite insertion techniques and liners in preparations with high c-factors - an in vitro study. King Saud University J Dental Sci. 2013; 2(4): 57-64.
18. Chair side rapid disinfection of gutta-percha cones with three different commonly used chemical agents: An ex-vivo study. Egyptian Dental J. 2013; 59: 845-853.
19. Restore to success - the posterior composite resin restoration: A case report. Tanta Dental J. 2012; 8(1): 80-85.
20. Anatomical position of mental foramen: A review of literature. Global J Med Public Health. 2012; 1(1): 61-64.
21. Role of calcium hydroxide in endodontics: A review of literature. Global J Med Public Health. 2012; 1(1): 66-70.
22. Comparing the mercury manometer with oscillometric devices: Clinical implications. Journal of Dental Practice & Medical Sciences. 2012; 1(1):
23. Management of bio-waste in dental clinics. Journal of Rural Dental Practice. 2012; 1(1): 48-52.

Dr.Saurabh Gupta, MDS


Oral and Maxillofacial Surgeon
Bangalore, India

BiographyResearch InterestScientific ActivitiesPublications

Dr.Saurabh Gupta holds Masters Degree in Oral & Maxillofacial Surgery and has been in surgical practice since 2014. He is also trained in multiple allied surgical disciplines including Implantology and Laser dentistry. He is involved in cosmetic dentistry including smile design (Certified in ClearPath, botox & fillers). He has published his papers in various National and International journal publications and magazines like Dentistry today(U.S), Access(U.S) etc. He is an editorial board member for many national and international journals. He is also working as a Medical Academic writer & Research Scientist since 2010 at one of the renowned freelancing sites www.freelancer.com

His research interest include Dental Implants, Laser Dentistry, Oral and Maxillofacial Surgery, Dental pain.

1. Dentistry Today (USA): http://www.dentistrytoday.com/news/todays-dental-news/item/645-laser-dentistry-requires-bright-practice-management
2. Saurabh G, Rubina K. Implant Stability Measure: Critical Review of Various Methods. Dent Implants Dentures. 2016; 1(1): 1-4. Web site. http://www.omicsgroup.org/journals/implant-stability-measure-critical-review-of-various-methods-did-1000110.php?aid=77888
3. Gupta S, Khatoon R. Laser-assisted cosmetic dentistry. J Dental Lasers. 2016; 10(1): 16-18. Web site. http://www.jdentlasers.org/article.asp?issn=2321-1385;year=2016;volume=10;issue=1;spage=16;epage=18;aulast=Gupta;type=0
4. Gupta S, Mahapatra N. A Review of Perimplantitis and Lasers. J Dental Medical Sciences. 2015; 14(1): 1-Web site. http://www.iosrjournals.org/iosr-jdms/papers/Vol14-issue3/Version-1/A014310104.pdf
5. Gupta S, Khatoon R. An Update on Safety Measures in Laser Dentistry. J Dental Medical Sciences. 2015; 14(11): 123-126. Web site. http://www.iosrjournals.org/iosr-jdms/papers/Vol14-issue11/Version-8/X014118123126.pdf
6. Gupta S, Khatoon R. Hair Loss- An analysis and Updated Treatment. J Dental Medical Sciences. 2015; 14(7): 77-81. Web site. http://www.iosrjournals.org/iosr-jdms/papers/Vol14-issue7/Version-2/P014727781.pdf
7. Sweeney C. Laser safety in dentistry. Gen Dent. 2008; 56(7): 653-659. Web site. http://www.thefreelibrary.com/Laser+safety+in+the+dental+office.-a0450695553
8. Jain H, Rao D, Sharma S, Gupta S. Assessment of speech in primary cleft palate by two-layer closure (Conservative management). J Surg Tech Case Rep. 2012; 4(1): 6-9. Web site. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3461783/
9. Shewale V, Deshmukh A, Sorathia R, Shinde S, Baonerkar H. Unicystic Ameloblastoma: A Case Report. Inter J Health Scie Research. 2014; 4(7): 313-316. Web site. http://journals.indexcopernicus.com/abstract.php?icid=1148731
10. A Recent Updates on Zirconia Implants: A Literature Review Gupta, Dent Implants Dentures 2016, 1: 1.
11. Gupta S. Zirconia Vs Titanium Implants - Deciding Factors Zirconia Vs Titanium Implants – Deciding Factors. J Dent Oral Disord Ther. 2016; 4(4): 1-2.
12. Gupta S. A recent updates on zirconia implants: A literature review. Dent Implants Dentures. 2016; 1:1. Web site. https://www.omicsgroup.org/journals/a-recent-updates-on-zirconia-implants-a-literature-review-.php?aid=82588
13. Gupta S. Zirconia Vs Titanium Implants – Deciding Factors. J Dent Oral Disord Ther. 2016; 4(4): 1-2. Web site. https://symbiosisonlinepublishing.com/dentistry-oraldisorders-therapy/dentistry-oraldisorders-therapy66.pdf

Barbara J. O’Kane, PhD

Associate Professor
Co-Director Oral Biology Graduate Program
Department of Oral Biology
Creighton University
School of Dentistry
Omaha, NE 68178, USA

BiographyResearch InterestScientific ActivitiesPublications

Dr. O’Kane is an Associate Professor in the Department of Oral Biology at Creighton University School of Dentistry in Omaha NE. She is currently Course Director for the D1 Neuroscience and also teaches in the D1 Gross Anatomy and Head and Neck courses. Prior to joining the faculty at Creighton University, Dr. O’Kane was at the University of Nebraska Medical Center in Omaha NE where she taught in the Gross Anatomy and Histology courses for first year medical students and conducted research in several areas of adult stem cells. Dr. O’Kane received her PhD from the University of Nebraska Medical Center. Her PhD Dissertation was entitled Bone Marrow Metastases in Breast Cancer.

Her research interests include: Mesenchymal stem cells, hematopoietic stem cells and tumor stem cells.

MEMBERSHIPS AND OFFICES IN PROFESSIONAL SOCIETIES


• International Society of Experimental Hematology
• International Society for Hematology and Genetic Engineering
• American Association of Clinical Anatomy
• American Association of Anatomists
• American Dental Education Association
• International Association for Dental Research


AWARDS


• UNMC Alvin Earle Outstanding Excellence in Teaching Award finalist 2005

PEER REVIEWED JOURNALS


1. OKane BJ, DeVetten MD, Jackson JL, Lacy JP, Farrell TL, Sharp JG. Multipotential mesenchymal stromal cells (MMSC) ameliorate graft versus host disease in a mouse model, but major suppression of GVHD permits leukemic relapse. Stem Cell Discovery. 2014; 4: 27-43. doi: 10.4236/scd.2014.42004
2. Farrell TL, McGuire TR, Bilek LD, et al. Changes in the frequencies of human hematopoietic stem and progenitor cells with age and site. Experimental Hematology. 2014; 42: 146-154. doi: doi: 10.1016/j.exphem.2013.11.003.
3. Partha M, Farrell TL, et al. Heterogeneity of functional properties of Clone 66 murine breast cancer cells expressing various stem cell phenotypes. PLOS ONE. 2013; 8(11): 1-15. doi: 10.1371/journal.pone.0078725
4. Tuljaputkar S, Jackson J, Brusnahan S, OKane B, Sharp J. Characterization of a mesenchymal stem cell line that differentiates to bone and provides niches supporting mouse and human hematopoietic cells. Stem Cell Discovery. 2012; 2(1): 5-14. doi: 10.4236/scd.2012.21002
5. Tuljapurkar SR, Brusnahan SK, Garvin KL, et al. Changes in human bone marrow fat content associated with changes in hematopoietic stem cell numbers and cytokine levels with aging. Journal of Anatomy. 2011; 219(5): 574-581. doi: doi: 10.1111/j.1469-7580.2011.01423.x
6. McGuire TR, Brusnahan SK, Bilek LD, et al. Inflammation Associated with Obesity: Relationship with Blood and Bone Marrow Endothelial Cells. Obesity. 2011; 19(11). doi: doi: 10.1038/oby.2011.246
7. Brushnahan SK, McGuire TR, Jackson JD, et al. Human blood and marrow side population stem cell numbers decline with age, with an increase in quality of surviving stem cells: Correlation with cytokines. Mechanisms of Ageing and Development. 2010; 131: 718-722.
8. Jackson JD, Mann SL, Murphy BO, Perry GA, Anderson RW, Crouse DA, Sharp JG. Modulation of hematopoiesis in recipients of factor producing transformed Iymphohematopoietic stromal cells. Leukemia Review International. 1983; 1: 188-189.
9. Sharp JG, Udeaja GC, Jackson JD, Mann SL, Murphy BO, Crouse DA. Transplantation of adherent cells from murine long term bone marrow cultures. In: Gale RP, et al, eds. For: Leukemia: Recent Advances in Biology and Treatment. New York, USA: Alan Liss; 1985.
10. Crouse DA, Murphy BO, Sharp JG. Characteristics of submucosal Iymphoid tissue located in the proximal colon of the rat. J. Anat. 1989; 162: 53-65.
11. OKane Murphy B, Jackson J, Dicke K. Analysis of variations in cryomedium and methods of freezing on human bone marrow stem cells. In: Worthington White DA, Gee A, Gross S, eds. Bone Marrow Purging and Processing. New York, USA: Wiley Liss; 1991: 361-366.
12. Kessinger A, OKane Murphy Bj, Jackson J, Ward B, Kloster T, Dicke K. A comparison of different cryomedia and methods of freezing human hematopoietic stem cells obtained from bone marrow and peripheral blood for storage. Int. J. Cell Cloning. 1991; 10(Suppl 1 ).
13. Knoop FC, Owens M, Marcus JN, Murphy B. Elevation of calcium in rat enterocytes by Escherichia coli Heat stable (Sta) enterotoxin. Current Microbiol. 1991; 23: 291-296. doi: 10.1007/BF02092033
14. Dicke KA, OKane Murphy BJ, Kessinger A, Jackson J. Influence of short term incubation of hematopoietic cells with growth factors on production of progenitor cells. Int. J. Cell Cloning. 1991; 10(Suppl 1): 50-52. doi: 10.1002/stem.5530100718
15. Alter R, OKane Murphy BJ, Korth D, et al. Characterization of hematopoietic stem cells in human cord blood. In: Worthington White DA, Gee A, Gross S, eds. Bone Marrow Purging and Processing. New York, USA: Wiley Liss; 1994; 393-398.
16. Jackson JD, Letheby B, OKane Murphy B, et al. Kinetics of low and high dose granulocyte/macrophage colony stimulating factor mobilization of peripheral blood stem cells. In: Worthington White DA, Gee A, Gross S, eds. Bone Marrow Purging and Processing. New York, USA: Wiley Liss; 1994: 643-647.
17. OKane Murphy BJ, Jackson J, et al. CD34 analysis in EPO mobilized peripheral blood stem cells. In: Worthington White DA, Gee A, Gross S, eds.Bone Marrow Purging and Processing. New York, USA: Wiley Liss; 1994: 371-376. 18. Kessinger A, Bishop MR, Jackson JD, et al. Erythropoietin for mobilization of circulating progenitor cells in patients with previously treated relapsed malignancies. Exp. Hematol. 1995; 23: 609-612.
19. Bishop MR, Jackson JD, Tarantolo SR, et al. Ex vivo treatment of bone marrow with phosphorothioate oligonucleotide OL(1)p53 for autologous transplantation in acute myelogenous leukemia and myelodysplastic syndrome. J Hemat. 1997; 6: 441-446.
20. Traystman MD, Cochran GT, Hake SJ, et al. Comparison of molecular cytokeratin 19 reverse transcriptase polymerase chain reaction (CK19 RT-PCR) and immunocytochemisrty detection of micrometastatic breast cancer cells in hematopoietic harvests. J Hematotherapy. 1997; 6: 551-561. doi: 10.1089/scd.1.1997.6.551
21. Sharp JG, Kessinger A, Clause SR, Mann SL, OKane Murphy BJ. Concurrent partial body irradiation prevents cytokine mobilization of blood progenitor cells: An effect mediated by a circulating factor. J Hematotherapy. 1998; 7: 343-349.
22. Schneiderman MH, Jackson JD, Joshi SS, Clark-Pierce L, Murphy BJ, Schniederman GS. Radiation Research. 1998; 149: 147-154.
23. Mata JE, Joshi SS, Tracewell WG, et al. Pharmacokinetics and in vivo effects of a six base oligodeoxynucleotide with anticancer and hematopoietic activities in swine. J Hematotherapy and Stem Cell Research. 2000; 9: 205-214.
24. Kessinger A, Mann S, OKane Murphy B, Jackson J, Sharp JG. Circulating factors may be responsible for strain-specific responses to mobilizing cytokines. Experimental Hematology. 2001; 29(6): 775-778. doi: 10.1016/S0301-472X(01)00642-7
25. Sharp JG, McGuire TR, Mann SL, Murphy B, Kessinger A. Plasma from poorly mobilizing subjects inhibits cytokine-induced murine blood stem cell mobilization. Cytotherapy. 2002; 4(4): 365-373. doi: 10.1080/146532402760271154
26. OKane Murphy BJ, Joshi S, Kessinger A, Reed E, Sharp JG. A murine model of bone marrow micrometastases in breast cancer. Clinical and Experimental Metastasis. 2002; 19(7): 561-569.
27. Reed E, Kessinger A, Murphy B, Tarantolo S, Traystman M, Sharp JG. Occult tumor cells detected in autologous blood stem cell harvests have no impact on five year outcomes for 4-9 node positive breast cancer patients treated with adjuvant high dose therapy and stem cell transplantation. Bone Marrow Transpl. 2003; 31: 571-574. doi: 10.1038/sj.bmt.1703878
28. Sharp JG, OKane Murphy BJ, Jackson JD, Brusnahan SK, Kessinger MA, Neff JR. Promises and pitfalls of stem cell therapy for promotion of bone healing. Clinical Orthopedics and Related Research. 2005; 435: 52-61.
29. Kessinger A, OKane Murphy BJ, Jackson JD, Sharp JG. An ex vivo model of hematopoietic stem cell mobilization. Cytotherapy. 2005; 7(6): 463-469.

Gururaj Arakeri, BDS, MDS

Senior Faculty
Department of Oral and Maxillofacial Surgery
Navodaya Dental College and Hospital
Raichur, Karnataka, India

BiographyResearch InterestScientific ActivitiesPublications

Dr. Arakeri completed his undergraduate from AME’s Dental college of Gulbarga university and post-graduate specialization from Bapuji Dental College and Hospital, Davangere of Rajiv Gandhi University of Health sciences Bangalore, India. Initially, he served as a general practitioner for six years in Shahapur, a remote place in Karnataka. During his general practice, he has conducted various treatment and awareness Dental health camps in rural areas of Shahapur town. He is a renowned Kannada dental health writer in Karnataka and has got more than 100 Kannada dental health articles published in leading newspapers and magazines. He has done a significant work on Oral Submucous Fibrosis which is well appreciated in the medical field. He has given various techniques and theories to the field of maxillofacial surgery. Currently, he is involved in many Oral submucous fibrosis human and animal studies in Hyderabad – Karnataka region of Karnataka.
Dr. Arakeri is associated with the department of oral and maxillofacial surgery of Navodaya Dental College and Hospital Raichur Karnataka.

His research interests include Oral Submucous Fibrosis, Oral cancer, TMJ ankylosis and orthognathic surgeries.

INTERNATIONAL STUDY AWARD:

•(2011) British Association of Oral and Maxillofacial Surgeon (BAOMS) Personal Research Grant award for a study on oral Sub mucous fibrosis in Yadgir district of INDIA. (Only Indian to receive the grant from BAOMS)
•(2012) BAOMS personal Research Grant award for the second part of study on oral Sub mucous fibrosis in Yadgir district of INDIA. (Only Indian to receive the grant from BAOMS second time)
•(2013) The Paul Toller Research Prize British Association of Oral and Maxillofacial Surgery (BAOMS) October 2013. (Only Indian to receive the prize from BAOMS)


MEMBERSHIP:

• The British Association of Oral and Maxillofacial Surgeons
• AOCMF
• Association of Oral and Maxillofacial Surgeons of India

1. Arakeri G, Arali V. Tooth section technique and pain upon elevation in third molar removal. International Journal of Oral and Maxillofacial Surgery. 2010; 39(1): 98-99. doi: 10.1016/j.ijom.2009.10.007
2. Arakeri G, Arali V. A new hypothesis of cause of syncope: Trigeminocardiac reflex during extraction of teeth. Medical Hypotheses. 2010; 74(2): 248-251. doi: 10.1016/j.mehy.2009.09.027.
3. Arakeri G. Autologous saliva transfusion: Treatment for HIV? Medical Hypotheses.2010; 74(5): 772-776. doi: 10.1016/j.mehy.2009.12.016
4. Arakeri G, Arali V, Brennan PA. Cleft lip and palate: An adverse pregnancy outcome due to undiagnosed maternal and paternal coeliac disease. Medical Hypotheses. 2010; 75(1): 93-98. doi: 10.1016/j.mehy.2010.01.047.
5. Arakeri G. Wire loop technique for retrieval and reduction of the displaced condylar fragment. British Journal of Oral and Maxillofacial Surgery. 2010; 48(6): 486-487. doi: 10.1016/j.bjoms.2010.05.012.
6. Kusanale A, Mackenzie N, Arakeri G, Mcleod N, Peter A, Brennan PA . A summary of trauma and trauma-related papers published in BJOMS during 2008-2009. British Journal of Oral and Maxillofacial Surgery. 2010; 48: 455-458. doi: 10.1016/j.bjoms.2010.05.014.
7. Arakeri G, Raghuram C.G, Reddy S, Arali V. Arakeris Reflex: An Alternative Pathway for Dento-Cardiac Reflex Mediated Syncope. Dental Hypotheses. 2010; 1(1).
8. Rai KK, Arakeri G, Khaji SI. A bony landmark RAI triangle to prevent misplaced and misdirected medial cut in SSRO. Journal of Maxillofacial and Oral Surgery. 2011; 10(1): 90-92. doi: 10.1007/s12663-010-0042-7.
9. Arakeri G, Brennan PA. Trigeminocardiac Reflex: Potential Risk Factor for Syncope in Exodontia? Journal of Oral and Maxillofacial Surgery. 2010; 68: 292. doi: 10.1016/j.joms.2010.05.094.
10. Arakeri G, Kusanale A, Zaki GA, Peter A. Pathogenesis of post-traumatic ankylosis of the temporomandibular joint: a critical review Brennan. British Journal of Oral and Maxillofacial Surgery. 2012; 50: 8-12. doi: 10.1016/j.bjoms.2010.09.012.
11. Arakeri G, Brennan PA. Inadvertent injection of formalin mistaken for local anesthetic agent: report of a case. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology. 2012; 113(5): 581-582. doi: 10.1016/j.tripleo.2011.04.017
12. Arakeri G, Brennan PA. Using Ferguson mouth gag to improve the visibility and surgical access in TMJ surgery (Arakeris TMJ Technique). International Journal of Oral and Maxillofacial Surgery. 2011; 40: 1004. doi: 10.1016/j.ijom.2011.04.012.
13. Arakeri G, Brennan PA. Povidone-iodine: An anti-oedematous agent? International Journal of Oral and Maxillofacial Surgery. 2011; 40: 173-176. doi: 10.1016/j.ijom.2010.09.012
14. Arakeri G, Brennan PA. The role of concomitant mandibular fractures in disc displacement and development of TMJ ankylosis secondary to sagittal fractures of the mandibular condyle. International Journal of Oral and Maxillofacial Surgery. 2011; 40: 1333-1335. doi: 10.1016/j.ijom.2011.04.018.
15. Arakeri G, Brennan PA. Accidental injection of formalin into oral soft tissue: are medications the only treatment? Journal of Oral and Maxillofacial Surgery. 2012; 70(4): 755-756. doi: 10.1016/j.joms.2011.12.038.
16. Arakeri G, Brennan PA. Dose-dependent sustained local release of dexamethasone from biodegradable thermosensitive hydrogel of PEG-PLGA-PEG Triblock copolymers in the possible prevention of TMJ re-ankylosis (Arakeris TMJ release technique). Medical Hypotheses. 2012; 78(5): 682-686. doi: 10.1016/j.mehy.2012.02.010.
17. Arakeri G, Rai KK, Shivakumar HR, Jayade B. A randomized clinical trial to compare the efficacy of submucosal Aprotinin injection and intravenous Dexamethasone in reducing pain and swelling after third molar surgery: A prospective study. Journal of Maxillofacial and Oral Surgery. doi: 10.1007/s12663-012-0364-8.
18. Arakeri G, Colbert S, Rosenbaum G, Brennan PA. Full length articles published in BJOMS during 2010-11- An analysis by sub-specialty and study type. British Journal of Oral and Maxillofacial Surgery. 2012; 50(8): 749-756. doi: 10.1016/j.bjoms.2012.08.017.
19. Arakeri G, Brennan PA. Oral submucous fibrosis: an overview of the pathogenesis, aetiology, classification, and principles of management. British Journal of Oral and Maxillofacial Surgery. 2013; 51(7): 587-593. doi: 10.1016/j.bjoms.2012.08.014
20. Arakeri G, Brennan PA. Dietary copper: A novel predisposing factor for oral submucous fibrosis? Medical Hypotheses. 2012; 43(6): 1004-1007. doi: 10.1016/j.mehy.2012.11.038.
21. Patil RS, Chakravarthy C, Sunder S, Arakeri G. Large Maxillary Cystic Lesion Causes Nasal Obstruction: A Case Report. Clinical dentistry. 2012; 23-26.
22. Arakeri G, Patil SG, Ramesh DNSV, Hunasgi S, Brennan PA. Evaluation of the possible role of copper ions in drinking water in the pathogenesis of oral submucous fibrosis: a pilot study. Journal of Oral and Maxillofacial Surgery. 2014; 52(1): 24-28. doi: 10.1016/j.bjoms.2013.01.010.
23. Arakeri G, Brennan PA. Povidone–iodine and hydrogen peroxide mixture soaked gauze pack: A novel haemostatic technique. Journal of Oral and Maxillofacial Surgery. 2013; 71(11): 1833.e1-1833.e3. doi: 10.1016/j.joms.2013.07.025.
24. Waghray S, Asif SM, Arakeri G. Streptomycin-Lidocaine injections for the treatment of Post Herpetic Neuralgia: Report of 3 cases with literature review. European Journal of Dentistry. 2013; 7(Suppl 1): S105.

Michelle A. (Kurpakus) Wheater, PhD

Associate Professor with Tenure
Director of Research
Department of Biomedical and Diagnostic Sciences
University of Detroit Mercy School of Dentistry
2700 Martin Luther King Jr. Blvd.
Detroit, MI 48208-2576, USA

BiographyResearch InterestScientific ActivitiesPublications

Dr. Wheater received a Ph.D. in Biochemistry from Lowa State University, Ames, Iowa, and conducted postdoctoral research at Northwestern University Medical School, Chicago, Illinois. She is currently the Director of Research and Student Academic Leadership Development and Division Director of Biomedical Sciences at University of Detroit Mercy School of Dentistry, Detroit, Michigan. Dr. Wheater is a member of the American Dental Education Association and AADR/IADR.

Her research interests include: An investigation of the effect of polyphenols and other natural molecules as anti-inflammatory and wound healing agents.

PROFESSIONAL ORGANIZATIONS:

•(1982-1992) American Society for Cell Biology
•(1989-2004) Association for Research in Vision and Ophthalmology
•(1998-2000) Member, Womens Affairs Committee
•(2004-Present) American Dental Education Association
•(2006-2010) Liaison, ADEA CCI
•(2008-2012) Member, Council of Faculties
•(2009-2013) MedEdPortal Advisory Board
•(2009-2010) Leadership Institute Fellow
•(2012-2013) Chair, Basic Science Caucus
•(2011-2012) Secretary, Anatomical Sciences Section
•(2012-2013) Chair-Elect, Anatomical Science Section
•(2013-2014) Chair, Anatomical Sciences Section
•(2005-Present) International Association for Dental Research


ACADEMIC SERVICE:

School of Dentistry

•(2005-2007) Advisor to Dental Hygiene Class of 2007
•(2009-2013) Advisor to Dental Class of 2013
•(2005) Chair, Search Committee, Faculty, Diagnostic Sciences
•(2013) Search Committee, Faculty, Department of Endodontics
•(2014) Search Committee, Faculty, Department of Periodontics
•(2014) Chair, Search Committee, Faculty, Department of Biomedical and Diagnostic Sciences


School of Dentistry Standing Committees

•(2005-2009) Dental Hygiene Curriculum Committee
•(2005-Present) Academic Performance Committees
•(2005-2008) Faculty Development Committee
•(2006-2008) Chair
•(2008-Present) Ex officio
•(2005-2007) Committee on Committees
•(2013-2015) Committee on Committees
•(2006-2007) Research Committee
•(2007-Present) Ex officio


School of Dentistry Ad Hoc Committees

•(2008-2009) Strategic Planning Committee
•(2010-2013) Implementation Committee
•(2010-2014) CODA Compliance Committee
•(2012-Present) SoTL Curriculum and Innovation Initiative Committee
•(2012-2014) SOD PreDoctoral Dental Self-Study Steering Committee
•(2012-2014) AdHoc Committee 2 for Self Study
•(2012-2014) AdHoc Committee 9 for Self Study, Chair
•(2013) CODA Narrative Group


University Standing Committees

•(2006-Present) Institutional Review Board (Secretary)
•(2008-2010) Faculty Development Team


University Ad Hoc Committees

•(2010-Present) OSPRA Advisory Committee
•(2011-Present) Conflict of Interest Committee
•(2013-Present) Grants Review Team


COMMUNITY SERVICE

•(2008, 2011) UDM School of Dentistry Community Open House
•(2009) MIDOR Michigan Day of Oral Health
•(2010, 2012) Give Kids a Smile Day
•(2012) ADEA Online Career Fair Academic Dentistry Booth Monitor
•(2014) Reviewer for AAMC Medical Education meeting programming
•(2011-2014) Reviewer for ADEA programming (workshops, seminars, posters)


HONORS:

•(1989-1991) NIH/National Eye Institute National Research Service Award (1989-1991)
•(1992) Association for Research in Vision and Ophthalmology Travel Fellowship
•(1997, 2000) Wayne State University School of Medicine College Teaching Award
•(2004, 2005) UDMSOD Outstanding Didactic Faculty Member
•(2005, 2006) Whos Who in America
•(2005) AcademicKeys Whos Who in Medical Sciences Education

1. Klatte DH, Kurpakus MA, Grelling KA, Jones JCR. Immunochemical characterization of three components of the hemidesmosome and their expression in cultured epithelial cells. J Cell Biol. 1989; 109: 3377-3390.
2. Kurpakus MA, Stock EL, Jones JCR. Expression of the 55-kD/64-kD corneal keratins in ocular surface epithelium. Invest Ophthalmol Vis Sci. 1990; 31: 448-456.
3. Kurpakus MA, Stock EL, Jones JCR. Analysis of wound healing in an in vitro model: early appearance of laminin and a 125x103 Mr polypeptide during adhesion complex formation. J Cell Sci. 1990; 96: 651-660.
4. Kurpakus MA, Jones JCR. A novel hemidesmosomal plaque component: tissue distribution and incorporation into assembling hemidesmosomes in an in vitro model. Exp Cell Res. 1991; 194: 139-146. doi: 10.1016/0014-4827(91)90143-I
5. Jones JCR, Kurpakus MA, Cooper HM, Quaranta V. A function for the integrin alpha6beta4 in the hemidesmosome. Cell Reg. 1991; 2: 427-438.
6. Lichtor T, Kurpakus MA, Guerney M. Differential expression of insulin-like growth factor in human meningiomas. Neurosurg. 1991; 29: 405-410.
7. Kurpakus MA, Quaranta V, Jones JCR. Surface relocation of alpha6beta4 integrins and assembly of hemidesmosomes in an in vitro model of wound healing. J Cell Biol. 1991; 115: 1737-1750.
8. Stock EL, Sambol BJ, Kurpakus MA, Jones JCR. Adhesion complex formation after small keratectomy wounds in the cornea. Invest. Ophthalmol Vis Sci. 1992; 33: 304-313.
9. Kurpakus MA, Stock EL, Jones JCR. The role of basement membrane in differential expression of keratin proteins in epithelial cells. Dev Biol. 1992; 150: 243-255. doi: 10.1016/0012-1606(92)90239-D
10. Lichtor T, Kurpakus MA, Guerney ME. Expression of insulin-like growth factors and their receptors in human meningiomas. J Neuro-Oncol. 1993; 17: 183-190.
11. Kurpakus MA, Esco M, Maniaci MT. Expression of keratins K12, K4 and K14 during development of the mouse eye. Curr Eye Res. 1994; 13: 805-814.
12. Smithson MW, Kurpakus MA. Localization of a corneal basement membrane glycoconjugate in bovine eye. Curr Eye Res. 1995; 14: 959-968.
13. Hazlett LD, Masinick S, Mezger B, Kurpakus M, Barrett R, Garrett M. Ultrastructural, immunohistological and biochemical characterization of cultured mouse corneal epithelial cells. Ophthalmic Res. 1996; 28: 50-56.
14. Vassallo JC, Kurpakus MA. Nuclear matrix proteins of bovine corneal and conjunctival epithelium. Curr Eye Res. 1996; 15: 899-904.
15. Fujii JT, Su F, Woodbury DJ, Kurpakus MA, Hu XT, Pourcho RI. Plasma membrane calcium ATPase immunoreactivity in synaptic terminals of chick Edinger-Westphal nucleus. Brain Res. 1996; 734: 193-202.
16. Wu X, Kurpakus M, Hazlett LD. Some P. aeruginosa pilus-binding proteins of human corneal epithelium are cytokeratins. Curr Eye Res. 1996; 15: 782-791.
17. Gassner H, Esco M, Smithson MW, Kurpakus MA. Differential effects of transforming growth factors on localization of adhesion complex proteins following corneal epithelial cell wounding. Curr Eye Res. 1997; 16: 387-395.
18. Qin P, Piechocki M, Lu S, Kurpakus MA. Localization of basement membrane-associated protein isoforms during development of the ocular surface of mouse eye. Dev Dyn. 1997; 209: 367-376. doi: 10.1002/(SICI)1097-0177(199708)209:4<367::AID-AJA4>3.0.CO;2-G
19. Qin P, Kurpakus MA. The role of laminin-5 in TGF/EGF-mediated corneal epithelial cell motility. Exp Eye Res. 1998; 66: 569-579. doi: 10.1006/exer.1997.0455
20. Kurpakus MA, Lin L. The lack of extracellular laminin 2 chain deposition correlates to the loss of conjunctival epithelial keratin K4 localization in culture. Curr Eye Res. 1999; 18: 28-38.
21. Kurpakus MA, Daneshvar C, Davenport J, Kim A. Human corneal epithelial cell adhesion to laminins. Curr Eye Res. 1999; 19: 106-116.
22. Invited Review: Kurpakus-Wheater M, Kernacki KA, Hazlett LD. Corneal cell proteins and ocular surface pathology. Biotech & Histochem. 1999; 74: 146-159.
23. Lin L, Kurpakus-Wheater M. Differential rapid adhesion of bovine ocular surface epithelial cells to laminin isoforms. Curr Eye Res. 1999; 19: 293-299.
24. Invited Review: Kurpakus-Wheater M, Kernacki KA, Hazlett LD. How the “window” stays clear. Prog Histochem Cytochem. 2001; 36: 185-259.
25. Lin L, Daneshvar C, Kurpakus-Wheater M. Evidence for differential signaling in human conjunctival epithelium adherent to laminin isoforms. Exp Eye Res. 2000; 70: 537-546.
26. Kurpakus-Wheater M. Laminin-5 is a component of preserved human amniotic membrane. Curr Eye Res. 2001; 22: 353-357.
27. Esco MA, Wang Z, McDermott ML, Kurpakus-Wheater M. Potential role for laminin-5 in hypoxia-mediated apoptosis of human corneal epithelial cells. J Cell Sci. 2001; 114: 4033-4040.
28. Lin L, Kurpakus-Wheater M. Laminin alpha5 chain adhesion and signaling in conjunctival epithelial cells. Invest. Ophthalmol. Vis Sci. 2002; 43: 2615-2621.
29. Sosne G, Hafeez S, Greenberry AL, Kurpakus-Wheater M. Thymosin alpha4 promotes human conjunctival epithelial cell migration. Curr Eye Res. 2002; 24: 268-273.
30. Esco MA, Hazlett LD, Kurpakus-Wheater M. Pseudomonas aeruginosa binds to extracellular matrix deposited by human corneal epithelial cells. Invest Ophthalmol Vis Sci. 2002; 43: 3654-3659.
31. Wang Z, Kurpakus-Wheater M. Decreased plasminogen activator inhibitor-1 secretion in hypoxic corneal epithelial cells results in increased urokinase plasminogen activator activity. Int J Biochem & Cell Biol. 2003; 35: 339-348.
32. Kurpakus-Wheater M, Sexton R, McDermott ML, Mrock LK, Sosne G. Caspase-9 activation in hypoxic human corneal epithelial cells. Apoptosis. 2003; 8: 681-689.
33. Sosne G, Xu L, Prach L, et al. Thymosin beta 4 stimulates laminin-5 production independent of TGF-beta. Exp Cell Res. 2004; 293: 175-183. doi: 10.1016/j.yexcr.2003.09.022
34. Dowgiert J, Sosne G, Kurpakus-Wheater M. Laminin-2 stimulates the proliferation of epithelial cells. Cell Proliferation. 2004; 37: 161-175. doi: 10.1111/j.1365-2184.2004.00292.x
35. Sosne G, Siddiqi A, Kurpakus-Wheater M. Thymosin beta 4 inhibits corneal epithelial cell apoptosis following ethanol exposure in vitro. Invest Ophthalmol Vis Sci. 2004; 45: 1095-1100. doi: 10.1167/iovs.03-1002
36. Wang Z, Sosne G, Kurpakus-Wheater M. Plasminogen activator inhibitor-1 (PAI-1) stimulates human corneal epithelial cell adhesion and migration in vitro. Exp Eye Res. 2005; 80: 1-8. doi: 10.1016/j.exer.2004.06.006
37. Sosne G, Albeiruti A, Hollis B, Siddiqi A, Ellenberg D, Kurpakus-Wheater M. Thymosin beta 4 inhibits benzalkonium chloride-mediated apoptosis in corneal and conjunctival epithelial cells in vitro. Exp Eye Res. 2006; 83: 502-507. doi: 10.1016/j.exer.2006.02.001
38. Sosne G, Qiu P, Christopherson PL, Wheater MK. Thymosin beta 4 suppression of corneal NFkB: a potential anti-inflammatory pathway. Exp Eye Res. 2007; 84: 663-669. doi: 10.1016/j.exer.2006.12.004
39. Qiu P, Wheater MK, Sosne G. Matrix metalloproteinase activity is necessary for thymosin beta 4 promotion of epithelial cell migration. J Cell Physiol. 2007; 212: 165-173. doi: 10.1002/jcp.21012
40. Sosne, G, Qiu, P, Kurpakus-Wheater M. Thymosin beta 4 and the eye: I can see clearly now the pain is gone. Ann NY Acad Sci. 2007; 1112: 114-122. doi: 10.1196/annals.1415.004
41. Sosne G, Qiu P, Kurpakus-Wheater M. Thymosin beta 4: a novel corneal wound healing and anti-inflammatory agent. Clin Ophthalmol. 2007; 1: 1-7.
42. Reti R, Kwon E, Qiu P, Wheater M, Sosne G. Thymosin beta 4 is cytoprotective in human gingival fibroblasts. Eur J Oral Sci. 2008; 116: 424-430. doi: 10.1111/j.1600-0722.2008.00569.x.
43. Zhang J, Kumar A, Wheater M, Yu FSX. Lack of MD2 expression in human corneal epithelial cells is an underlying mechanism of lipopolysaccharide (LPS) unresponsiveness. Immunol Cell Biol. 2009; 87: 141-148. doi: 10.1038/icb.2008.75.
44. Sosne G, Qui P, Goldstein AL, Wheater M. Biological activities of thymosin 4 defined by active sites in short peptide sequences. FASEB J. 2010; 24: 2144-2151. doi: 10.1096/fj.09-142307
45. Sosne G, Qui P, Wheater M. Thymosin beta 4 and corneal wound healing: vision of the future. Ann NY Acad Sci. 2010; 1194: 190-198. doi: 10.1111/j.1749-6632.2010.05472.x.
46. John V, Papageorge M, Jahangiri L, et al. Recruitment, development, and retention of dental faculty in a changing environment. J Dent Ed. 2011; 75: 82-89.
47. Damas BA, Wheater M, Bringas J, Hoen M. Cytotoxicity comparison of mineral trioxide aggregates and endosequence bioceramic root repair materials. J Endo. 2011; 37: 372-375. doi: 10.1016/j.joen.2010.11.027
48. Qiu P, Wheater M, Sosne G. Thymosin beta 4 inhibits TNF--induced NFB activation, IL-8 expression, and the sensitizing effects by its partners PINCH-1 and ILK. FASEB J. 2011; 25: 1815-1826. doi: 10.1096/fj.10-167940
49. Gao N, Kumar A, Guo H, Wheater M, Yu F-S. Topical flagellin-mediated innate defense against Candida albicans keratitis. Invest Opthalmol Vis Sci. 2011; 52: 3074-3082. doi: 10.1167/iovs.10-5928
50. Hirschman W, Wheater M, Bringas J, Hoen M. Cytotoxicity comparison of three direct pulp capping materials with a new bioceramic root repair putty. J Endo. 2012; 38: 385-388.
51. Wheater MA, Falvo J, Ruiz F, Byars M. Chlorhexidine, ethanol, LPS and nicotine do not enhance the cytotoxicity of a calcium hydroxide pulp capping material. Int Endo J. 2012; 45: 989-995. doi: 10.1111/j.1365-2591.2012.02057.x.
52. Balasundaram A, Shah P, Bringas. Comparison of Cone-Beam Computed Tomography and Periapical Radiography in predicting treatment decision for periapical lesions – A clinical study. Int J Dentistry. 2012; 2012: 920815. doi: 10.1155/2012/920815.
53. Kwon E, Cabanilla Jacobs L, Wheater M. Gingival Crevicular Fluid Levels of Thymosin beta4 in Periodontal Health and Disease. J Adv Oral Res. 2013; 4(1): 1-6.
54. Chang K-CJ, Wheater MA, Cabanilla Jacobs L, Litonjua L. Interleukins in Gingival Crevicular Fluid in Patients with Definitive Full Coverage Restorations. Compend Contin Educ Dent. 2014; 35(4): e18-24.
55. Ahmad M, Williams J, Al-Aboussi R, Wheater M. Substance P concentration in saliva of patients who report dental pain. J Adv Oral Res. 2014; 5(2): 1-10.
56. Wheater MA, Mouabbi A. Effects of cotinine on human gingival fibroblast migration. Dent Open J. 2(1): 25-31. doi: 10.17140/DOJ_2_106

Muy-Teck Teh, PhD

Senior Lecturer in Head and Neck Cancer
Centre for Clinical and Diagnostic Oral Sciences
Barts and The London School of Medicine and Dentistry
Queen Mary University of London
The Blizard Institute
4, Newark Street, London, E1 2AT, UK

BiographyResearch InterestScientific ActivitiesPublications

Dr. Teh received his Biomedical Science degree (B.Sc. Hons, 1996) and PhD in Molecular Physiology (2000) from Kings College London, UK. Following two postdoctoral trainings funded by Wellcome Trust and Cancer Research UK. He is currently a tenured Senior Lecturer (Associate Professor) in Head and Neck Cancer at the Barts and the London School of Medicine and Dentistry, Queen Mary University of London, leading a clinical translational research group investigating cancer biomarker discovery, molecular diagnostics, molecular reprogramming of adult epithelial stem cell renewal, differentiation, and senescence. Overall, he aims to translate basic science into clinical applications and towards personalised medicine based on a combination of patients genetic, epigenetic, exosomal and gene expression signatures. Dr. Teh has published papers in high impact journals such as Nature Genetics, Cancer Research, Journal of Cell Science, American Journal of Human Genetics, Molecular Cancer, Genes Chromosomes and Cancer and International Journal of Cancer. He is also on editorial boards of several reputed international peer-reviewed journals and acted as grant reviewers for various UK and EU funding bodies and charities. Dr. Teh has international collaborators from USA, Norway, Switzerland, Sri Lanka, Malaysia and China on clinical translation of molecular diagnostics for early detection of head & neck cancer.

His research interests include: Finding new biomarker genes for predicting early oral cancer formation.

AWARDS


• Molecule of the Year (2010) for his pioneering research on FOXM1 in human cancer initiation

PEER-REVIEWED ARTICLES


1. Sugden D, Pickering H, Teh MT, Garratt PJ. Melatonin receptor pharmacology: Toward subtype specificity. Biol. Cell. 1997; 89: 531-537.
2. Davis DJ, Garratt PJ, Tocher DA, et al. Mapping the melatonin receptor 5. Melatonin agonists and antagonists derived from tetrahydrocyclopent[b]indoles, tetrahydrocarbazoles and hexahydrocyclo-hept[b]indoles. Differences in binding affinity and biological activity between enantiomers. J. Med. Chem. 1998; 41: 451-467.
3. Teh M-T, Sugden D. Comparison of the structure-activity relationships of melatonin receptor agonists and antagonists: lengthening the N-acyl side-chain has differing effect on potency on Xenopus melanophores. Naunyn-Schmiedebergs Arch. Pharmacol. 1998; 358: 522-528.
4. Teh M-T, Sugden D. The putative melatonin receptor antagonist GR128107 is a partial agonist on Xenopus laevis melanophores. Br. J. Pharmacol. 1999; 126: 1237-1245.
5. Sugden D, Yeh L-K, Teh MT. Design of subtype selective melatonin receptor agonists & antagonists. Reprod. Nutr. Dev . 1999; 39: 335-344.
6. Garratt PJ, Jones R, Yeh LK, et al. Mapping the melatonin receptor 6. Melatonin agonists and antagonists derived from 6H-Isoindolo[2,3-a]indoles, 5,6-Dihydroindolo-[2,1-a]isoquinolines and 6,7-Dihydro-5H-benzo[3,4]azepino[1,2-a]indoles. J. Med. Chem. 2000; 43: 1050-1061.
7. Teh M-T, Sugden D. An endogenous 5-HT7 receptor mediates pigment granule dispersion in Xenopus laevis melanophores. Br. J. Pharmacol. 2001; 132: 1799-1807.
8. Teh MT, Sugden D. Desensitization of pigment granule aggregation in Xenopus leavis melanophores: Melatonin degradation rather than receptor down-regulation is responsible. J. Neurochem. 2002; 81: 719-727.
9. Teh MT, Wong ST, Neill GW, Ghali LR, Philpott MP, Quinn AG. FOXM1 is a downstream target of Hedgehog signalling in basal cell carcinomas. Cancer Research. 2002; 62: 4773-4780.
10. Davies DJ, Faust R, Garratt PJ, et al. Binding affinity and biological activity of oxygen and sulfur isosteres at melatonin receptors as a function of their hydrogen bonding capability. Bioorg. Chem. 2004; 32: 1-12.
11. Sugden D, Davidson K, Hough KA, Teh M-T Melatonin, melatonin receptors and melanophores: A moving tale. Pigment Cell Res. 2004; 17: 454-460.
12. Kelsell DP, Norgett EE, Unsworth H, et al. Mutations in ABCA12 underlie harlequin ichthyosis, the most severe congenital ichthyosis. Am J. Hum. Genet. 2005; 76: 794-803.
13. Teh M-T, Blaydon D, Tracy Chaplin, et al. Genome-wide SNP Microarray Mapping in Basal Cell Carcinomas Unveils Uniparental Disomy as a Key Somatic Event. Cancer Res. 2005; 65: 8597-8603.
14. Tsotinis A, Vlachou M, Papahatjis DP, et al. Mapping the melatonin receptor. 7. Subtype selective ligands based on beta-substituted N-acyl-5-methoxytryptamines and beta-substituted N-acyl-5-methoxy-1-methyltryptamines. J. Med. Chem. 2006; 49: 3509-3519.
15. Blaydon D, Ishii Y, O’Toole1 EA, et al. R-spondin 4 (RSPO4), a secreted protein implicated in Wnt signalling, is mutated in inherited anonychia. Nat. Genet.2006; 38: 1245-1247.
16. Teh M-T, Blaydon D, Ghali LR, et al. Role for non-canonical WNT16B in human epidermal keratinocyte proliferation and differentiation. J. Cell Sci. 2007; 120: 330-339.
17. Purdie KJ, Lambert SR, Teh M-T, et al. Allelic Imbalances and Chromosome 9p Microdeletion Demonstrated in Cutaneous Squamous Cell Carcinomas Using Single Nucleotide Polymorphism Microarray Analysis. Genes Chromosomes Canc. 2007; 46: 661-669
18. Faust R, Garratt PJ, Trujillo Perez MA, et al. 7-Substituted-melatonin and 7-substituted-1-methylmelatonin analogues: Effect of substituents on potency and binding affinity. Bioorg Med Chem. 2007; 15: 4543-4545.
19. Lalli A, Tilakaratne WM, Ariyawardena A, et al. An altered keratinocyte phenotype in oral submucous fibrosis: correlation of keratin K17 expression with disease severity. J. Oral Pathol. Med. 2008; 37: 211-220. doi: 10.1111/j.1600-0714.2007.00609.x
20. Tilakaratne WM, Iqbal Z, Teh M-T, et al. Up regulation of HIF-J. Oral Pathol. Med. 2008; 37: 372-377.
21. Teh M-T, Tilakaratne WM, Chaplin T, et al. Fingerprinting Genomic Instability in Oral Submucous Fibrosis J. Oral Pathol. Med. 2008; 37: 430-436. doi: 10.1111/j.1600-0714.2008.00643.x.
22. Gemenetzidis E, Bose A, Riaz MA, et al. FOXM1 Upregulation is an Early Event in Human Squamous Cell Carcinoma and it is Enhanced by Nicotine during Malignant Transformation. PLoS ONE. 2009; 4(3): e4849. doi: 10.1371/journal.pone.0004849
23. Teh M-T, Gemenetzidis E, Chaplin T, et al. Upregulation of FOXM1 Induces Genomic Instability in Human Keratinocytes. Mol Cancer. 2010; 9(1): 45. doi: 10.1186/1476-4598-9-45
24. Wang H, Teh M-T, Ji YM, et al. EPS8 Upregulates FOXM1 Expression, Enhancing Cell Growth and Motility. Carcinogenesis. 2010; 31(6): 1132-1141. doi: 10.1093/carcin/bgq058
25. Waseem A, Ali M, Odell EW, Fortune F, Teh M-T. Downstream Targets of FOXM1: CEP55 and HELLS are Cancer Progression Markers of Head and Neck Squamous Cell Carcinoma. Oral Oncology. 2010; 46: 536-542. doi: 10.1016/j.oraloncology.2010.03.022
26. Gemenetzidis E, Elena-Costea D, Parkinson EK, Waseem A, Wan H, Teh M-T. Induction of Human Epithelial Stem/Progenitor Expansion by FOXM1. Cancer Res. 2010; 70(22): 9515-9526. doi: 10.1158/0008-5472.CAN-10-2173
27. Tsang SM, Liu L, Teh M-T, et al. Desmoglein 3, via an interaction with E-cadherin, is associated with activation of Src. PLoS ONE. 2010; 5(12): e14211. doi: 10.1371/journal.pone.0014211
28. Teh M-T, Parkinson EK, Thurlow JK, Liu F, Fortune F, Wan H. A molecular study of desmosomes identifies a desmoglein isoform switch in head and neck squamous cell carcinoma. J. Oral Pathol. Med. 2011; 40(1): 67-76. doi: 10.1111/j.1600-0714.2010.00951.x
29. Pitiyage G, Lim KP, Gemenitzidis E, et al. Increased secretion of tissue inhibitors of metalloproteinases 1 and 2 (TIMPs -1 and -2) in fibroblasts are early indictors of oral sub-mucous fibrosis and ageing. J. Oral Pathol. Med. 2012.
30. Teh M-T, Gemenetzidis E, Patel D, et al. FOXM1 Induces a Global Methylation Signature that Mimics the Cancer Epigenome in Head and Neck Squamous Cell Carcinoma. PLoS ONE. 2012; 7(3): e34329. doi: 10.1371/journal.pone.0034329
31. Bose A, Teh M-T, Hutchison IL, Leigh IM, Wan H, Waseem A. Two Mechanisms Regulate Keratin 15 in Keratinocytes: Role of PKC/AP-1 and FOXM1 Mediated Signalling. PLoS ONE. 2012; 7(6): e38599. doi: 10.1371/journal.pone.0038599
32. Teh M-T. Cells Brainwashed by FOXM1: Do they have potential as Cells Brainwashed by FOXM1: Do they have potential as biomarkers of cancer?. Biomark Med. 2012; 6(4): 499-501. doi: 10.2217/bmm.12.33
33. Teh M-T. FOXM1 coming of age: Time for translation into clinical benefits? Front. Oncol. 2012; 2: 146. doi: 10.3389/fonc.2012.00146
34. Teh M-T, Hutchison IL, Costea DE, et al. Exploiting FOXM1-Orchestrated Molecular Network for Early Squamous Cell Carcinoma Diagnosis and Prognosis. Int. J. Cancer. 2013; 132(9): 2095-2106.
35. Bose A, Teh M-T, Mackenzie IC, Waseem A. Keratin 15 as a biomarker of epidermal stem cells. Int J Mol Sci. 2013; 14: 19385-19398. doi: 10.3390/ijms141019385
36. Hwang SJ, Mahadevan S, Qadir F, et al. Identification of FOXM1-induced epigenetic markers for head and neck squamous cell carcinomas. Cancer. 2013; 119: 4249-4258. doi: 10.1002/cncr.28354
37. Philpott M, Pantazi E, Gemenetzidis E, et al. GLI2 induces genomic instability in human keratinocytes by inhibiting apoptosis. Cell Death Diseases. 2014; 5: e1028. doi: 10.1038/cddis.2013.535
39. Parker MO, Annan L, Brocka AJ, et al. Moderate alcohol exposure during early brain development increases stimulus-response habits in adulthood. Addiction Biol. 2014. doi: 10.1111/adb.12176
40. Parker MO, Annan L, Kanellopoulous et al. The Utility of Zebrafish to Study the Mechanisms by which Ethanol Affects Social Behavior and Anxiety During Early Brain Development. Prog Neuro psycho pharmacol Biol Psychiatry. 2014. doi: 10.1016/j.pnpbp.2014.03.011
41. Teh MT. Is salivary exosome the answer to early detection of oral cancer? Dent Open J. 2015; 2(2): e3-e4. doi: 10.17140/DOJ-2-e002

Fei Liu, DDS, PhD

Assistant Professor
Division of Prosthodontics
Department of Biologic and Materials Sciences
University of Michigan: School of Dentistry
Ann Arbor, MI 48109, USA

BiographyResearch InterestScientific ActivitiesPublications

Dr. Liu earned his BS, MS and DDS degree from West China School of Stomatology, Sichuan University. Subsequently, he completed a PhD in the Skeletal, Craniofacial and Oral Biology Program and a specialty certificate in Prosthodontics, both from the University of Connecticut Health Center. Dr. Liu is a Diplomate of the American Board of Prosthodontics and fellow of American College of Prosthodontists (ACP). He is also an active member of American Society for Bone and Mineral Research, American Academy of Fixed Prosthodontics (AAFP), American Association of Dental Research (AADR), International Association of Dental Research (IADR). Currently, Dr. Liu serves as the Chair of Stanley Tylman Research Committee of AAFP and member of ACP Research Committee.

His research interests include: Mechanisms that regulate physiological and pathological bone metabolism, skeletal and craniofacial bone development and diseases.

HONORS AND PROFESSIONAL AWARDS

•(1990-1995) Excellent student awards, West China School of Stomatology, Si Chuan University
•(1997) First place of Xuan Rui Ling dental graduate student scholarship, West China School of Stomatology, Si Chuan University
•(1998) First place of DENTSPLY dental graduate student scholarship, West China School of Stomatology, Si Chuan University
•(1999-2003) Graduate student fellowship, University of Connecticut Health Center
•(2004) Young Investigator Award, Advances in Skeletal Anabolic Agents for the Treatment of Osteoporosis (American Society for Bone and Mineral Research)
•(2004) ASBMR Young Investigator Award, American Society for Bone and Mineral Research
•(2004) First place of Remo Sinibaldi Memorial Table Clinic Competition, American College of Prosthodontists
•(2010) Fellow, American College of Prosthodontists


MEMBERSHIPS IN PROFESSIONAL AND RESEARCH SOCIETIES

•(2003-Present) American Society for Bone and Mineral Research
•(2007-Present) American Society of Fixed Prosthodontics
•(2009-Present) International Chinese Musculoskeletal Research Society
•(2010-Present) American College of Prosthodontists
•(2013-Present) American Association of Dental Research
•(2013-Present) International Association of Dental Research

1. Xian S, Liu F, Gong P, et al. Three dimensional finite element analysis of a blade and natural teeth supported free end fixed partial denture(I. Stress distribution under concentrated loading). Chinese Journal of Oral Implantology. 1997; 2(3): 101-105.
2. Liu F, Gong P, Mao XY, et al. Three dimensional finite element analysis of a blade and natural teeth supported free end fixed partial denture(II. Stress analysis under dispersed loading). Chinese Journal of Oral Implantology. 1997; 2(3): 105-107.
3. Gong P, Liu F, Xian S, et al. Three dimensional finite element analysis of a blade and natural teeth supported free end fixed partial denture(III. Effect of the elastic modulus of framework on the stress distribution). Chinese Journal of Oral Implantology. 1997; 2(3): 107-109.
4. Liu F, Gong P, Mao XY. Implant and Natural Teeth Combined Fixed Denture. Chinese Journal of Oral Implantology. 1997; 2(4).
5. Liu F, Zhao YF, Li MZ. Establishment of In Situ Hybridization Method for the Expression of Type I Collagen in Rat Periodontal Ligament. Journal of Clinical Stomatology. 2000; 16(3): 135-137
6. Zhao YF, Liu F, Li MZ. Effect of lost bite force on the expression of bFGF in rat molar periodontal ligament. Chinese Journal of Stomatology. 2000; 35(5): 353-355.
7. Liu F, Zhao YF. Effect of Increased Bite Force on the Expression of bFGF in rat molar periodontal ligament. Journal of Modern Stomatology. 2001; 15(1): 3-5.
8. Liu F, Zhao YF. Expression of type I collagen mRNA in rat molar periodontal ligament under normal bite force. West China Journal of Stomatology. 2001; 19(2): 74-76.
9. Liu F, Zhao YF, Li MZ, Liu W, Wang H. Effect of increased and decreased bite force on morphology of periodontal tissues. Journal of West China University of Medical Sciences. 2001; 32(1): 77-79, 82.
10. Liu F, Zhao YF. Effect of decreased bite force on the temporal and spatial expression of type I collagen mRNA in rat molar periodontal ligament. Journal of West China University of Medical Sciences. 2001; 32(2): 267-270.
11. Liu F, Zhao YF. Effect of increased bite force on the temporal and spatial expression of type I collagen mRNA in rat PDL. Journal of Comprehensive Stomatology. 2002; 18(2): 77-79
12. Liu F, Woitge HW, Braut A, et al. Expression and activity of osteoblast-targeted Cre recombinase transgenes in murine skeletal tissues. International Journal of Development Biology. 2004; 48: 645-653.
13. Liu F, Huang YF, Kream BE. Cloning and identification of novel CREM isoforms expressed by osteoblasts. Calcified Tissue International. ; 77(2): 91-95.
14. Liu F, Lee S-K, Adams DJ, Gronowicz GA, Kream BE. CREM deficiency in mice blunts the anabolic effect of intermittent PTH treatment on bone mass acquisition.Bone. 2007; 40(4): 1135-1143.
15. Chandhoke TK, Huang Y-F, Liu F, et al. Osteopenia in transgenic mice with osteoblast-targeted expression of the inducible cAMP early repressor. Bone. 2008; 43(1): 101-109. doi: 10.1016/j.bone.2008.03.012.
16. Liu F, Kohlmeier S, Wang C-Y. Wnt signaling and skeletal development. Cellular Signaling. 2008; 20(6): 999-1009.
17. Liu F, Lee JY, Wei H-J, et al. FIP200 is required for the cell-autonomous maintenance of fetal hematopoietic stem cells. Blood. 2010; 116(23): 4806-4814. doi: 10.1182/blood-2010-06-288589.
18. Liu F, Guan J-L. FIP200, an essential component of mammalian autophagy is indispensable for fetal hematopoiesis. Autophagy. 2011; 7(2): 54-55.
19. Guan J-L, Simon AN, Prescott M, et al. Autophagy in stem cells. Autophagy. 2013; 9(6): 830-849.
20. Chang J, Liu F, Lee M, et al. NF-B inhibits osteogenic differentiation of mesenchymal stem cells by promoting β-catenin degradation, Proceedings of the National Academy of Sciences of the United States of America. 2013; 110(23): 9469-9474. doi: 10.1073/pnas.1300532110.
21. Ma F, Molusky MM, Liu F, et al. Autophagy deficiency by hepatic FIP200 deletion uncouples steatosis from liver injury in NAFLD. Molecular Endocrinology. 2013; 27(10): 1643-1654. doi: 10.1210/me.2013-1153.
22. Liu F, Fang F, Yuan H, et al. Suppression of autophagy by FIP200 deletion leads to osteopenia in mice through the inhibition of osteoblast terminal differentiation. Journal of Bone and Mineral Research. 2013; 28(11): 2414-2430. doi: 10.1002/jbmr.1971.
23. Chen Y, Wei H, Liu F, Guan J-L. Hyper-activation of mTORC1 Promotes Breast Cancer Progression through Enhancing Glucose Starvation-induced Autophagy and Akt Signaling. Journal of Biological Chemistry. 2014; 289(2): 1164-1173. doi: 10.1074/jbc.M113.526335.
24. Liu F, Kwok V, Agar J. Water aerosol protective device used during tooth preparation for maxillectomy patients. Journal of Prosthetic Dentistry. 2014; 111: 169-170. doi: 10.1016/j.prosdent.2013.08.008
25. Barndt P, Zhang H, Liu F. Immediate loading: from biology to biomechanics. report of the committee on research in fixed prosthodontics of the american academy of fixed prosthodontics. Journal of Prosthetic Dentistry. 2014; S0022-3913(14)00422-3. doi: 10.1016/j.prosdent.2014.08.011
26. Wang L, Mishina Y, Liu F. Osterix-Cre transgene causes craniofacial bone development defect. Calcified Tissue International. 2015; 96(2):129-37. doi: 10.1007/s00223-014-9945-5
27. Fang F, Sun S, Wang L, et al. Neural crest-specific TSC1 deletion in mice leads to sclerotic craniofacial bone lesion. Journal of Bone and Mineral Research. 2015. doi: 10.1002/jbmr.2447
28. Liu F, Masri R. A Technique to Obtain and Transfer Jaw Relation Records from Conventional Complete Denture to Implant-supported Complete Denture. Dentistry Open Journal. 2015; 2(1): 44-46. doi: 10.17140/DOJ_2_109

Tamer Abdel-Azim, DDS

Assistant Professor of Prosthodontics
Department of Oral Health and Rehabilitation
University of Louisville School of Dentistry
Louisville, KY 40202, USA

BiographyResearch InterestScientific ActivitiesPublications

Dr. Abdel-Azim is an Assistant Professor of Prosthodontics at the University of Louisville School of Dentistry. He obtained his Prosthodontics Certificate at the University of Rochester. Dr. Abdel-Azim maintains a private practice limited to implant and Esthetic Dentistry. He is a fellow of the International Team for Implantology, a member of the American Dental Association and the American College of Prosthodontists. Dr. Abdel-Azim has lectured nationally and internationally on dental implants, complex rehabilitations and digital dentistry. He has several publications in peer-reviewed journals in the fields of prosthodontics and implant dentistry. He maintains a private practice limited to implants, esthetic dentistry and prosthodontics.

His research interests include: Implant and Digital Dentistry.

PROFESSIONAL MEMBERSHIPS

• Member, American College of Prosthodontists
• Member, American Academy of Maxillofacial Prosthetics
• Member, American Dental Education Association
• Member, World Federation of Orthodontists
• Fellow, International Team for Implantology
• Reviewer, Center for Evidence-based Dentistry, American Dental Association
• Reviewer, Journal of Oral Implantology
• Reviewer, Journal of Dental Education
• Reviewer, Journal of Operative Dentistry
• Reviewer, Clinical, Cosmetic and Investigational Dentistry
• Reviewer, International Journal of General Medicine
• Reviewer, Journal of Health Care Leadership
• Editorial Review Board Member, Anaplastology


HONORS AND AWARDS

•(2011-2012) William R Wolfe Award, Outstanding full-time faculty, University of Louisville School of Dentistry
•(2012) Participant, Evidence-based Dentistry Champions Conference, Chicago, IL
•(1999-2002) Very Good with Honors in all dental school years, Cairo University
•(1999-2002) Deans List in dental school
•(2002) Egyptian Dental Association Award for Academic Excellence

1. Zandinejad A, Atarodi M, Abdel-Azim T, Leonhart RM, Morton D. Complete oral rehabilitation of a patient with hereditary gingival fibromatosis: A clinical report. J Prosthet Dent. 2014; S0022-3913(14): 00381-00383. doi: 10.1016/j.prosdent.2014.07.013.
2. Abdel-Azim T, Zandinejad A, Elathamna E, Lin WS, Morton D. The influence of digital fabrication options on the accuracy of dental implant-based single units and complete arch frameworks. Int J Oral Maxillofac Implants. 2014. doi: 10.11607/jomi.3577.
3. Khan Z, Abdel-Azim T. A direct technique to fabricate an intraoral shield for unilateral head and neck radiation. J Prosthet Dent. 2014;112(3):689-91. doi: 10.1016/j.prosdent.2014.01.013.
4. Metz MJ, Miller CJ, Lin WS, Abdel-Azim T, Zandinejad A, Crim G. Dental student perception and assessment of their clinical knowledge in educating patients about preventive dentistry. Eur J Dent Educ. 2014. doi: 10.1111/eje.12107.
5. Geminiani A, Abdel-Azim T, Ercoli C, Changyong F, Meirelles L, Massironi D. In Vitro Comparison of the Use of Oscillating vs. Rotating Instruments for Teeth Preparation on Finish Line Surface Roughness. J Prosthet Dent. 2014;112(1):51-58. doi:
6. Metz MJ, Abdel-Azim T, Miller CJ, et al. Implementation of a Laboratory Quality Assurance Program: The Louisville Experience. J Dent Educ. 2014;78(2):195-205. doi:
7. Zandinejad A, Abdel-Azim T, Lin WS, Morton D. Fabrication of a fixed multipurpose template retained by existing dental implants. J Prosthet Dent. 2013;110(2):144-146. doi: 10.1016/S0022-3913(13)60356-X.
8. Abdel-Azim T, Fantuzzo J, Batalocco G, Cho S, Ercoli C, Morton D. Oral rehabilitation of an edentulous patient using two-segment Le fort I repositioning and implant-supported fixed prostheses. Int J Oral Maxillofac Implants. 2013;28(2):e106-e111. doi: 10.11607/jomi.2575.

Luis Eduardo Almeida, DDS, MS, PhD

Assistant Professor
Department of Surgical Sciences – Oral Surgery
School of Dentistry
Marquette University
1801 W Wisconsin Ave
Milwaukee, WI 53233, USA

BiographyResearch InterestScientific ActivitiesPublications
EDUCATIONAL QUALIFICATION:

• 1993 - Doctor in Dental Surgery ( DDS) - Federal University - Parana State -Brazil
• 1998 - Certificate in Oral and Maxillofacial Surgery - Federal University - Parana State -Brazil
• 2003 - Residency in Oral and Maxillofacial Surgery - Northwestern University -Chicago -USA
2006 - Master of Science -Pontifical Catholic University of Parana - Brazil
• 2013 - PhD - Pontifical Catholic University of Parana - Brazil


PROFESSIONAL EXPERIENCE

• (2013 - present): Clinical Assistant Professor, Surgical Sciences - Oral Surgery Marquette University - School of Dentistry
• (2004 - 2013): Professor, Specialization in Oral & Maxillofacial Surgery Brazilian Dental Association -Parana State, Credit Hours: 20-week
• (2004 - 2013): Professor, Continuing Education in Ambulatory Oral Surgery Brazilian Dental Association -Parana State, Credit Hours: 10-week
• (2005 - 2013): Assistant Program Director -Residency Program in Oral & Maxillofacial Hospital Universitário Evangélico de Curitiba
• (2003 - 2013): Oral & Maxillofacial Surgeon private practice

His research interests include: Temporomandibular Joint and Orthognathic Surgery.

PROFESSIONAL MEMBERSHIPS

• American Dental Association
• Wisconsin Dental Association
• American Dental Society of Anesthesiology
• Brazilian Dental Association
• Latin American association of Oral and Maxillofacial Surgeons

1. Almeida LE, Doetzer A, Camejo F, Bosio J. Operative management of idiophaticmyositis ossificans of lateral pterygoid muscle: Case report and review of literature. Int J Surg Case Rep. 2014; 5(11): 796-799.
2. Almeida LE, Caporal K, Ambros V, et al. Immunohistochemical expression of matrix metalloprotease-2 and matrixmetalloprotease-9 in the disks of patients with temporomandibular joint dysfunction. J Oral Pathol Med. 2014. doi: 10.1111/jop.12213.
3. de AlcantaraCamejo F, Almeida LE, Doetzer AD, et al. FasL expression in articular discs of human temporomandibular joint and association with osteoarthrosis. J Oral Pathol Med. 2013. doi: 10.1111/jop.12089.
4. Sicurezza E, Loreto C, Almeida LE, et al. Expression of β-defensin 4 on temporomandibular joint discs with anterior displacement without reduction. J Craniomaxillofac Surg. 2013; S1010-182(13): 00052-0058. doi: 10.1016/j.jcms.2013.01.036.
5. Caltabiano R, Leonardi R, Musumeci G, et al. Apoptosis in temporomandibular joint disc with internal derangement involves mitochondrial-dependent pathways. An in vivo study. Acta Odontol Scand. 2013; 71(3-4): 577-83. doi: 10.3109/00016357.2012.700060.
6. Loreto C, Galanti C, Almeida LE, et al. Expression and localization of aquaporin-1 temporomandibular joint disc with internal derangement. J Oral Pathol Med. 2012; doi: 10.1111/j.1600-0714.2012.01156.x.
7. Carla L, Almeida LE, Paula T, Rosalia L. Apoptosis in displaced temporomandibular joint disc with and without reduction: an immunohistochemical study. Journal of Oral Pathology & Medicine. 2011; 40: 103-110. doi: 10.1111/j.1600-0714.2010.00920.x.
8. Rosialia L, Almeida LE , Mugurel R, Edoardo S, Giuseppe P, Carla L. Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Expression Correlates to Temporomandibular Joint Disk Degeneration. The Journal of Craniofacial Surgery. 2011; 22: 504-508. doi: 10.1097/SCS.0b013e3182087394.
9. Rosialia L, Almeida LE, Carla L. Lubricinimmunohistochemical expression in human temporomandibular joint disc with internal derangement. Journal of Oral Pathology & Medicine. 2011. doi: 10.1111/j.1600-0714.2011.01012.x.
10. Almeida LE, Filho d-O, Antonio M. Giant Mandibular Condyle Osteoma. The Journal of Craniofacial Surgery. 2011; 22: 1147-1149. doi: 10.1097/SCS.0b013e318210baee.
11. Rosialia L, Almeida LE, Paula TC, Carla L. Occurrence and regional distribution of TRAIL and DR5 on temporomandibular joint discs: comparison of disc derangement with and without reduction. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontics. 2010; 109: 244-251. doi: 10.1016/j.tripleo.2009.09.028.
12. Rosialia L, Rita MM, Almeida LE, Paula TC, Carla L. Limited Fatty Infiltration Due to Apoptosis in Human Degenerated Temporomandibular Joint Disks. The Journal of Craniofacial Surgery. 2010; 21: 1508-1511. doi: 10.1097/SCS.0b013e3181ef2dc9.
13. Carla L, Almeida LE, Rita MM, Rosialia L. TRAIL, DR5 and caspase 3-dependent apoptosis in vessels of diseased human temporomandibular joint disc. An immunohistochemical study. European Journal of Histochemistry. 2010; 54: 175-179.
14. Almeida L, Baioni C, Martins A, et al. Histologic and histomorphometric analysis of posterior region of the human temporomandibular disc. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontics. 2008; 105: e6-e11. doi: 10.1016/j.tripleo.2007.10.004.
15. Oliveira Filho MA, Almeida LE, Pereira J. Plasma ricoemplaquetas de coelhos: introduçãoa um modelo animal experimental. ABCD. Arquivos Brasileiros de Cirurgia Digestiva. 2008; 21: 175-179.
16. Ritto F, Almeida LE, Kallal R. Traumatic neuroma following sagittal split osteotomy of the mandible. International Journal of Oral and Maxillofacial Surgery. 2007; 36: 11.
17. Wang K, Almeida LE, Olsson A. Volume Analysis of the Proximal Tibial Metaphysis. Journal of Oral and Maxillofacial Surgery. 2007; 65: 2425-2429.
18. Oliveira Filho MA, Almeida LE, Pereira J. Sialolito Gigante Associado à ístulaCutanea. RBC. Revista Internacional de Cirurgia e Traumatologia Bucomaxilofacial. 2007; 8: 35-38.
19. Almeida LE, Wang K. Treatment of the proeminet mandibular Angle by uisng a custom made surgical implant. Journal of Oral and Maxillofacial Surgery. 2005; 63: 1052-1056.
20. Almeida LE, Fabio B. Hiperplasia de condilo mandibular: Relato de quatrocasos. Revista Brasileira de Odontologia. 2005; 13: 36-40.
21. Almeida LE, Oliveira Filho MA. Hipertrofia de Musculo Temporal: Relato de caso. RBPO. Revista Brasileira de Patologia Oral. 2005; 4: 114-118.
22. Almeida LE. Mandible Cleft: Report of a case and Review of the Literature. Journal of Oral and Maxillofacial Surgery EstadosUnidos. 2002; 60: 681-684.
23. Almeida LE. CondromatoseSinovial da Articulação Temporomandibular - Relato de caso. Revista ABO Nacional, Brasil. 2002; 10(5): 305-308.

Pradeep Bhagavatula, BDS, MPH, MS

Assistant Professor
Program in Dental Public Health
Department of Clinical Services
Marquette University School of Dentistry
1801 W Wisconsin Ave
Milwaukee, WI 53233, USA

BiographyResearch InterestScientific ActivitiesPublications

Dr. Bhagavatula is currently an Assistant Professor in Program in Dental Public Health at Marquette University School of Dentistry, Milwaukee, Wisconsin. He received his Bachelor of Dental Surgery from Bapuji Dental College and Hospital, Davangere, India, Master of Public Health from University of Alabama at Birmingham and Master of Science in Dental Public Health from University of Iowa. His primary research interest is in examining the role of social determinants of oral disease and dental care utilization.

His research interests include: Dental Health Services Research, Epidemiology of Oral Diseases.

HONORS AND AWARDS

•(2014) Omicron Kappa Upsilon, Xi Chapter
•(2012) Wisconsin Seal-A-Smile 2010-11. 100% Achievement Award. Milwaukee Children’s Oral Health Program. Children’s Health Alliance of Wisconsin and The Wisconsin Department of Health Services Oral Health Program
•(2009) Marquette University Research Development Program Award


PROFESSIONAL MEMBERSHIPS:

• International Association of Dental Research
• American Association of Dental Research
• American Association of Public Health Dentistry
• American Dental Education Association
• American Public Health Association
• Indian Dental Association

1. Bhagavatula P, Xiang Q, Eichmiller F, Szabo A, Okunseri C. Racial/ethnic disparities in provision of dental procedures to children enrolled in Delta Dental insurance in Milwaukee. Wisconsin. 2014; 74(1): 50-56. doi: 10.1111/j.1752-7325.2012.00366.x.
2. Bhagavatula P, Xiang Q, Szabo A, Eichmiller F, Kuthy RA, Okunseri CE. Rural-urban differences in dental service use among children enrolled in a private dental insurance plan. Wisconsin: analysis of administrative data. 2012; 12: 58. doi: 10.1186/1472-6831-12-58.
3. Gundersen DF, Bhagavatula P, Pruszynski JE, Okunseri CE. Dental Students Perceptions and Readiness to Provide Care for the Underserved Population. J Dent Educ. 2012; 76(9):1175-1182.


PEER-REVIEWED PUBLICATIONS (PRE-MARQUETTE):

4. Kataram M, Bhagavatula P, et.al. Infectivity enhanced adenovirus mediated melanoma differentiation associated gene-7(mda-7) therapy for ovarian cancer CA Leath 3rd. Gynecologic Oncology. 2004; 94(2):352-362.

Pouran Famili, DMD, MDS, MPH, PhD

Professor
Department of Periodontics
School of Dental Medicine
University of Pittsburgh
4200 Fifth Ave
Pittsburgh, PA 15260, USA

BiographyResearch InterestScientific ActivitiesPublications

Dr. Famili is Full Professor in the Department of Periodontics and Preventive Dentistry and Chair of the Department since 2005, with a secondary appointment as Full Professor in the University of Pittsburghs Clinical and Translational Science Institute. She graduated from the Periodontics Residency Program and received her Masters degree in Dental Science from the University of Pittsburgh, followed by the DMD, and then earned her MPH (2000) and the PhD in the field of Epidemiology in 2005. She has been a member of the Periodontics Faculty since 1986 and has served the University and the Profession with Distinction, becoming a Diplomate in both Periodontics and Implantology, and a fellow in the International Congress of Oral Implantologists, the American College of Dentists, and the International College of Dentists, among many others. She is active in both the local and national chapters of the Dental Honorary OKU, and in 2005 was a finalist for the Chancellors Distinguished Teaching Award. In addition to several publications on both topics, she has received financial grant support to study the relationship between dental implant placement and osteoporosis from the International Congress of Oral Implantologists and from NobelBiocare. She is a member of both the American Academy for Dental Research and the International Academy for Dental Research and has presented her research nationally and internationally. Dr. Famili has taken great pleasure in working to actively mentor the careers of periodontics residents and dental students throughout her own career at the University of Pittsburgh, and has produced many publications, presentations, and service learning opportunities, presented to peer-reviewed national and international dental and implantology meetings. She regularly peer-reviews research funding proposals for the National Institutes of Health, curriculum tools for the Med Ed Portal knowledge website (sponsored jointly by the Association of American Medical Colleges and ADEA), and scholarly articles for many different journals in the dental press. She is very active in academic dentistry, participating in the American Dental Education Associations Womens Affairs and Minority Affairs Committees, often presenting symposium topics regarding implantology, mentoring, or the first professional education of young dentists. Dr. Famili practices periodontics exclusively in the University of Pittsburgh faculty practice.


EDUCATION

University of Pittsburgh, certificate in periodontics 1979
University of Pittsburgh, M.D.S. 1980
University of Pittsburgh, D.M.D. 1985
University of Pittsburgh, MPH 2000
University of Pittsburgh, PhD 2005

Her research interests include: The relationship between Periodontal disease and Osteoporosis, and subsequently the effects of Osteoporosis on Dental Implant Survival.

MEMBERSHIPS IN PROFESSIONAL AND SCIENTIFIC SOCIETIES

•(1977- Present) American Academy of Periodontology
•(1977- Present) Pittsburgh Academy of Periodontology
•(1977-Present) Womens Dental Association, University of Pittsburgh
•(1977- Present) American Dental Association
•(1984-Present) Pennsylvania Dental Association
•(1984-Present) Western Pennsylvania Dental Association
•(1990-Present) American Academy Board of Periodontology
•(1992-Present) IADR (International Association for Dental Research)
•(1992-Present) Omicron Kappa Upsilon
•(1996-Present) Pennsylvania Academy of Periodontology
•(1998-Present) American College of Dentists
•(1998-Present) American Association of Dental Schools
•(2001) Fellow, American College of Dentists
•(2003-Present) Fellow, International College of Dentists
•(2008-Present) Fellow, International College of Oral Implantologists


HONORS

•(1987) Clinical Instructor of the Year, School of Dental Medicine, University of Pittsburgh
•(1987, 1988) Best Instructor in Periodontics, School of Dental Medicine, Department of Periodontics
•(1989, 1990) Honored Faculty, University of Pittsburgh Honors Convocation
•(1990) Marshall for Diploma Ceremony, School of Dental Medicine
•(1992) Membership, Omicron Kappa Upsilon, Beta Chapter, University of Pittsburgh, School of Dental Medicine
•(1998) Fellowship, American College of Dentists
•(2000) Selected by senior dental students as one of three faculty who were most effective teachers, School of Dental Medicine, University of Pittsburgh
•(2003) Fellowship, International College of Dentists
•(2005) Finalist, Chancellors Distinguished Teaching Award

1. Famili P. Effects of general cancer on the mouth. Journal of Iranian Dentistry. 1972.
2. Ceravolo FJ, Famili P, Li S. Alveolar ridge augmentation utilizing collagen wound dressing. International Journal of Oral Implantology. 1987; 4(2): 15-18.
3. Adams CKS, Famili P. Study of the effects of the drug FK506 on gingival tissues. Transplantation Proceedings. 1991; 23(6): 3193-3194.
4. Tupta-Veselicky L, Famili P, Ceravolo F, Zullo T. Evaluation of an electronic constant force periodontal probe. Journal of Periodontology. 1994; 65(6): 616-622.
5. Famili P, Mozayanfar K. Advancement of rapidly progressive periodontitis in patients without maintenance: A case report. Journal of Periodontology. 1995.
6. Weyant R, Pearlstein M, Chuark P, Forrest K, Famili P. Cauley JA. The association between osteopenia and periodontal attachment loss in older women. Journal of Periodontology. 1999; 70(9): 982-991.
7. Famili P, Cauley JA, Weyant R, Suzuki JB. Longitudinal analyses of the relationship between periodontal disease, tooth loss, and the rate of bone loss in older women. Journal of Periodontology. 2005; 76(1): 11-15.
8. Famili P, Suzuki JB. A prostate cancer therapy as a risk factor of osteoporosis and periodontitis. Journal of Practical Hygiene. 2006; 7-10.
9. Famili P, Cauley JA, Greenspan SL. Effect of androgen deprivation therapy on periodontal disease in men. Journal of Urology. 2007; 177(3): 921-924.
10. Famili P. Oral bone loss may be influenced by infection and osteoporosis. Journal of Evidence-based Dental Practice. 2009; 9(2): 99-100. doi: 10.1016/j.jebdp.2009.03.009.
11. Famili P, Short E. Compliance to periodontal maintenance at the University of Pittsburgh: Retrospective analysis of 315 cases. General Dentistry. 2010; e42-e47.
12. Ozturk A, Famili P, Vieira AR. The antimicrobial peptide DEFB1 is associated with caries. Journal of Dental Research. 2010; 89(6): 631-636. doi: 10.1177/0022034510364491.
13. Famili P, Mosher TA, Quigley S. Survival of dental implants among post-menopausal female dental-school patients taking oral bisphosphonates: A retrospective study. Compendium of Continuing Education in Dentistry. 2011; 32(6): e106-e109.
14. Heinrichs EP, Famili P. Dental school faculty teaching the periodontal-systemic connection to medical school students: A pilot mini-elective. Journal of Dental Education. 2011; 75(10): 1293-1407.
15. Famili P. Persons living with HIV may be more likely to seek preventive dental care if financial barriers to care are removed, if they are actively taking HIV medications, and if they are satisfied with their overall oral health. Journal of Evidence-Based Dental Practice. 2012; 12(3): 169-170. doi: 10.1016/j.jebdp.2012.07.002.
16. Famili P, Akmal O. Successful dental implant placement in a liver transplant survivor: literature review and report of a case. Oral Health Journal. 2013; (8): 42-45.
17. Famili P. Oral bisphosphonates and relationship to ONJ and dental implants. Dentistry. 2013; 4(1): 188.

Brian C. Muzyka, DMD, MS, MBA

Associate Professor
East Carolina University School of Dental Medicine
600 Moye Blvd., Greenville
North Carolina 27834, USA

BiographyResearch InterestScientific ActivitiesPublications

Dr. Muzyka is an Associate Professor at East Carolina University School of Dental Medicine in Greenville, North Carolina. Dr. Muzyka is also the Director of Hospital Dentistry for Vidant Medical Center, a 909 bed level 1 trauma center and tertiary care facility. He practices general dentistry and oral medicine at the Hospital Dentistry Dental Practice. Dr. Muzyka received his DMD from Temple University School of Dentistry, certificate in Oral Medicine from the University of Pennsylvania School of Dental Medicine, and his Master of Healthcare Management and Masters of Business Administration degrees from the University of New Orleans. He is the author of over 50 peer-reviewed articles, books, book chapters and monographs dealing with issues related to oral healthcare, healthcare management and business. His research centers on oral health, oral medicine and the delivery of dental care to medically complex patients. His most current research deals with tobacco cessation and prevention, salivary gland and signaling changes in Sjogrens syndrome and oral mucositis. He has lectured locally, nationally, and internationally on these subjects.

His research interests include: Tobacco cessation and prevention and salivary gland and signaling changes in Sjogrens syndrome.

PROFESSIONAL ASSOCIATIONS

• American Academy of Oral Medicine
• American Board of Oral Medicine
• American Dental Association
• North Carolina Dental Association
• Eastern North Carolina Dental Association


OFFICES AND POSITIONS

•(2001-2003) Secretary/Treasurer, Faculty Assembly, Louisiana State University Health Science Center, School of Dentistry
•(2000-2003) Delegate, Faculty Assembly, Louisiana State University Health Science Center, School of Dentistry


HONORS AND AWARDS

•(2000) Omicron Kappa Upsilon, National Dental Honor Society
•(2000) Sigma Iota Epsilon, National Business Honor Society

1. Imanguli M, Muzyka BC, Porter J, Meneray M. The effects of 5-fluorouracil on the mucosa of the rat. Oral Surg Oral Med Oral Pathol. 2003; 95: 418.
2. Dehler KR, Brannon R, Muzyka BC. Biopsied oral lesions in a geriatric population. Oral Surg Oral Med Oral Pathol. 2003; 95: 417.
3. Haralambidis C, Muzyka BC, Glick M. Incidence of Dental Disease in Adult Male HIV+ and HIVCohorts: A Descriptive Study. Oral Surg Oral Med Oral Pathol. 1995; 80: 422-423.

Ahmed El-Angbawi, BDS, MSc, PhD, MOrth (RCS Ed), FHEA

Clinical Lecturer in Orthodontics
University of Glasgow
Sauchiehall Street 378
Glasgow G2 3JZ, UK

BiographyResearch InterestScientific ActivitiesPublications

Dr. Ahmed El-Angbawi is a Clinical Lecturer in Orthodontics in the University of Glasgow, United Kingdom. Dr. El-Angbawi graduated from the Faculty of Dentistry, Alexandria University (Egypt) in 1999. He studied Orthodontics in Alexandria University, where he graduated with a Master Degree in Orthodontics. Dr. El-Angbawithen moved to the University of Glasgow, where he was appointed as a clinical lecturer in Orthodontics in 2009. He was awarded his PhD in Orthodontics from the University of Dundee in 2013, and upon completion of his CCST in Orthodontics in the University of Glasgow he was awarded MOrth from the Royal College of Surgeons in Edinburgh.
Dr. El-Angbawi is involved extensively in orthodontic undergraduate teaching and postgraduate programs in the United Kingdom and overseas. He holds a Certificate in Academic Practice (PGCAP) from the University of Glasgow, and his is also a Fellow of the Higher Education Academy in the United Kingdom.
Dr. El-Angbawi has a special interest in research related to effective orthodontic treatment and 3D prediction planning for orthognathic treatment. He published several articles in international journals and presented his research outcome in several national and international scientific meetings and conferences. He is a reviewer in several peer reviewed scientific journals.

His research interests includes: Effectiveness of orthodontic treatment, Randomised clinical trials, Systematic reviews, Orthodontically Induced Inflammatory Root Resorption (OIIRR).

AWARDS


• The Orthodontic Department was awarded the “Best Taught Undergraduate Subject” across the University of Glasgow in 2013
• The udergraduate periodontology prize at Alexandria University in 1999


OTHER SCIENTIFIC ACTIVITIES


• Reviewer in several scientific journals including: Journal of Dentistry and The Scientific World Journal
• Member of editorial board in the Dentistry and Medical Research Journal


MEMBERSHIP IN PROFESSIONAL SOCIETIES


•(2013) Higher Education Academy
•(2013) Royal College of Surgeons in Edinburgh
•(2011-Present) British Orthodontic Society
•(2009-Present) Glasgow Orthodontic Society
•(2008-Present) Tayside Orthodontic Society
•(2004-Present) Egyptian Orthodontic Society
•(1998-2004) International Association of Dental Research

1. El-Angbawi A, McIntyre GT, Bearn DR, Fleming PS. Non-surgical adjunctive interventions for accelerating tooth movement in patients undergoing fixed orthodontic treatment Protocol. Cochrane Database of Systematic Reviews. 2013; 12: CD010887.
2. Fleming PS, Pandis N, Johal A, El-Angbawi A, Fedorowicz Z. Adjunctive surgical procedures for accelerating tooth movement in patients undergoing orthodontic treatment (Protocol). Cochrane Database of Systematic Reviews. 2013; 6: CD010572.
3. Cross D, El-Angbawi A, McLaughlin P, et al. Developments in autotransplantation of teeth. Surg J R Coll Surg Edinb Irel. 2013; 11(1): 49-55. doi: 10.1016/j.surge.2012.10.003.
4. El-Angbawi A, McIntyre G, Bearn D, Thomson D. Film and digital periapical radiographs for the measurement of apical root shortening. J Clin Exp Dent. 2012; 4(5): e281-e285. doi: 10.4317/jced.50872.
5. El-Angbawi A, Cross D, Short L. Effectiveness of Twin Block appliance in the reduction of overjet in Class II div 1 malocclusion in Glasgow Dental Hospital & School. British Orthodontic Society Clinical Effectiveness Bulletin. 2012.
6. El-Angbawi AMF. Accelerating orthodontic treatment: a continuous challenge. Dent Open J. 2015; 2(3): 98-99. doi: 10.17140/DOJ-2-118

Yang Yanqi, BDS, MOrth RCS (Edin), PhD, FDS RCS (Edin

Clinical Assistant Professor in Orthodontics
Faculty of Dentistry
University of Hong Kong
Hong Kong

BiographyResearch InterestScientific ActivitiesPublications

Dr. Yang is the Clinical Assistant Professor in Orthodontics, Undergraduate Programme Director in Orthodontics in Faculty of Dentistry, the University of Hong Kong. She supervises the clinical and research work of MDS students and research of PhD students. She completed her orthodontic specialty training in Peking University and got doctoral degree in 2003. She was awarded Fellowship of Royal College of Surgeons of Edinburgh in 2013. She is the member of World Federation of Orthodontists, Hong Kong Society of Orthodontists, Hong Kong Dental Association, International Association of Dental Research, American Association of Orthodontists and European Orthodontic Society. She is the reviewer of International Journal of Dentistry, Journal of Investigative and Clinical Dentistry, The Angle Orthodontist, Scientific Research and Essays, European Journal of Orthodontics, Oral Health and Preventive Dentistry, Journal of Industrial & Engineering Chemistry, Regulatory Peptides, Phytotherapy Research, etc.

Her research interests include: Bone biology, Mechanism of orthodontic tooth movement, Orthodontics and Quality of Life, Obstructive Sleep Apnea, 3-D models in dental e-learning.

PRIZES AND AWARDS

•(2013) The 2nd prize of Poster Presentation Award, 24th South-East Asia Association for Dental Education (SEAADE) Annual Meeting
•(2013) Faculty Knowledge Exchange (KE) Award 2013, Faculty of Dentistry “Improving childrens oral health and development by terminating poor oral habits and promoting healthy ones”
•(2013) Outstanding Teaching Award (OTA) Team "PBL 2.0: E-learning for Problem-based Learning (PBL) at the Faculty of Dentistry"
•(2012) Best Poster Presentation Award, 23rd South-East Asia Association for Dental Education (SEAADE) Annual Meeting
•(2011) Best Poster Presentation Award, 22nd South-East Asia Association for Dental Education (SEAADE) Annual Meeting
•(2010) Honourable Mention Award of poster presentation, Hong Kong International Dental Expo and Symposium
•(2010) Houston Poster Award, Congress of the European Orthodontic Society


PROFESSIONAL QUALIFICATION

•(2013) Fellowship in Dental Surgery, the Royal College of Surgeons of Edinburgh (by virtue of being a holder of the specialty membership in orthodontics)
•(2012) Membership, European Orthodontic Society
•(2011) Membership, American Association of Orthodontists
•(2011) Membership, International Association for Dental Research
•(2009) Membership, Chinese Orthodontic Society (COS) (Registration No. of the specialty membership in COS: COS01094)
•(2008) Membership, Hong Kong Dental Association
•(2005) Fellowship, World Federation of Orthodontists
•(2005) Membership, Hong Kong Society of Orthodontists
•(2005) Diploma of Membership, the Royal College of Surgeons of Edinburgh
•(2013) Reviewer, Phytotherapy Research 2012- Reviewer, European Journal of Orthodontics2012- Reviewer, Oral Health and Preventive Dentistry
•(2012) Reviewer, Regulatory Peptides
•(2012) Reviewer, Journal of Industrial & Engineering Chemistry
•(2012) Reviewer, Scientific Research and Essays
•(2011) Reviewer, Chinese Medical Journal
•(2010) Reviewer, The Angle Orthodontist
•(2009) Reviewer, Journal of Investigative and Clinical Dentistry
•(2009) Reviewer, International Journal of Dentistry

1. Teh SK, Zheng W, Li S, et al. Multimodal nonlinear optical microscopy improves the accuracy of early diagnosis of squamous intraepithelial neoplasia. Journal of Biomedical Optics. 2013; 18(3): 036001. doi: 10.1117/1.JBO.18.3.036001.
2. Wenden A, Yang Y, Chai L, Wong RW. Salvia Miltiorrhiza Induces VEGF Expression and Regulates Expression of VEGF Receptors in Osteoblastic Cells. Phytotherapy Research. 2013; 19. doi: 10.1002/ptr.5031
3. Yang Y, Chin A, Zhang L, Lu J, Wong RW. The Role of Traditional Chinese Medicines in Osteogenesis and Angiogenesis. Phytotherapy Research. 2013. doi: 10.1002/ptr.4959.
4. Yang YQ, Tan YY, Wong R, Wenden A, Zhang LK, Rabie ABM. The role of vascular endothelial growth factor in ossification. International Journal of Oral Science. 2012; 4(2): 64-68. doi: 10.1038/ijos.2012.33
5. Zhan X, Zhang C, Dissanayaka WL, et al. Storage media enhance osteoclastogenic potential of human periodontal ligament cells via RANKL-independent signaling. Dental Traumatology. 2012; 29(1): 59-65. doi:10.1111/j.1600-9657.2012.01138.x
6. Wang W, Zeng XL, Zhang CF, Yang YQ. Malocclusions in Xia Dynasty in China. Chinese Medical Journal (English). 2012; 125(1): 119-122.
7. Zheng W, Li D, Li S, Zeng Y, Yang Y, Qu JY. Diagnostic value of nonlinear optical signals from collagen matrix in the detection of epithelial precancer. Optics Letters. 2011; 36(18): 3620-3622. doi: 10.1364/OL.36.003620.
8. Chin A, Yang Y, Chai L, Wong RWK, Rabie ABM. Effects of medicinal herb salvia miltiorrhiza on osteoblastic cells in vitro. Journal of Orthopaedic Research. 2011; 29(7): 1059-1063. doi:10.1002/jor.21376.
9. Yang Y, Yang YQ, Li XT, et al. Functional analysis of core binding factor a1 and its relationship with related genes expressed by human periodontal ligament cells exposed to mechanical stress. European Journal of Orthodontics. 2010; 32(6): 698-705. doi: 10.1093/ejo/cjq010.
10. Tan YY, Yang Y, Chai L, Wong RWK, Rabie ABM. Effects of Vascular Endothelial Growth Factor (VEGF) on MC3T3-E1. Orthodontics and Craniofacial Research. 2010; 13(4): 223-228. doi: 10.1111/j.1601-6343.2010.01498.x.
11. Yang YQ, Li XT, Rabie ABM, Fu MK, Zhang D. Human periodontal ligament cells express osteoblastic phenotypes under intermittent force loading in vitro. Frontiers in Bioscience. 2006; 11(1): 776-781.
12. Ng AF, Yang YQ, Wong RW, Hagg EU, Rabie AB. Factors regulating condylar cartilage growth under repeated load application. Frontiers in Bioscience. 2006; 11(1): 949-954.
13. Zhang D, Yang YQ, Li XT, Fu MK. The expression of osteoprotegerin and the receptor activator of nuclear factor kappa B ligand in human periodontal ligament cells cultured with and without 1α, 25-dihydroxyvitamin D3. Archives of Oral Biology. 2004; 49(1): 71-76. doi: http://dx.doi.org/10.1016/S0003-9969(03)00201-2
14. Chee D, Ren C, Yang Y. An overview on interproximal enamel reduction.Dent Open J. 2014; 1(1): 14-18. doi: 10.17140/DOJ-1-104

Wenyuan Shi, PhD

Professor and Chair of Oral Biology
UCLA School of Dentistry
Professor of Microbiology, Immunology and Molecular Genetics
UCLA School of Medicine
Le Conte Avenue 10833, Los Angeles, CA 90095 1668, USA

BiographyResearch InterestScientific ActivitiesPublications

Dr. Shi is a chairman and professor of Oral Biology at UCLA Schools of Dentistry. His laboratory has been using multidisciplinary approaches to study oral microbial pathogenesis with a specific focus on microbial biofilm, inter-species interaction and signal transduction. In addition, his laboratory is actively involved in the development of next generation of diagnostic and therapeutic tools against oral microbial infections, including instant chairside detection of oral pathogens and peptide based targeted antimicrobial therapeutics. These translational research efforts have resulted in novel technologies that are licensed and developed by major pharmaceutical, dental and biotech companies. Dr. Shi is also the founding scientist, chief science officer, and chairman of the scientific advisory board of C3 Jian Inc.
Dr. Shi obtained his BS degree from Fudan University (Shanghai) in 1984, acquired his Ph.D degree from University of Wisconsin-Madison in 1991 and fulfilled his postdoctoral training at University of California-Berkeley during 1992-1995. He is co-author and co-inventor of over 200 scientific articles and patents.

His research interests include: Multidisciplinary approaches to study oral microbial pathogenesis with a specific focus on microbial biofilm, inter-species interaction and signal transduction.

OTHER PROFESSIONAL ACTIVITIES

• Member of UCLA Dental Research Institute
• Member of UCLA Jonsson Cancer Center
• Editorial board, Applied and Environmental Microbiology
• Editorial board, Journal of Dental Research
• Editorial board, International Journal of Oral Biology
• Editorial board, Chemotaxis and Migration
• Editorial board, The Open Dentistry Journal
• Ad Hoc Reviewers for Nature, Science, PNAS, Mol. Micro. Current Biology, etc
• Regular member of NIH PCMB study section
• NSF grant ad hoc reviewer
• Ad Hoc reviewer of several other NIH study sections and different journals
• Chair of special panel reviewer for Chinese NSFC (Microbiology)

1. Adler J, Shi W. Galvanotaxis in bacteria. Cold Spring Harbor Symposia on Quantitative Biology. 1988; LIII: 23-25. doi: 10.1101/SQB.1988.053.01.006
2. Shi W, Zhou Y, Wild J, Adler J, Gross CA. DnaK, DnaJ, GrpE are required for flagellar synthesis in Escherichia coli. J Bacteriol. 1992; 174: 6256-6263.
3. Li C, Louise C, Shi W, Adler J. Adverse conditions which cause lack of flagella in Escherichia coli. J Bacteriol. 1993; 175: 2229-2235.
4. Shi W, Li C, Louise C, Adler J. Mechanism of adverse conditions causing lack of flagella in Escherichia coli. J Bacteriol. 1993; 175: 2236-2240.
5. Shi W, Lentz MJ, Adler J. Behaviorial responses of Escherichia coli to changes in temperature caused by electric shock. J of Bacteriol. 1993; 175: 5785-5790.
6. Shi W, Zusman DR. The two motility systems of Myxococcusxanthus show different selective advantages on various surfaces. Proc Natl Acad Sci USA. 1993; 90: 3378-3382. doi: 10.1073/pnas.90.8.3378
7. Shi W, Zusman DR. Fatal attraction. Nature. 1993; 366: 414-415. doi: 10.7554/eLife.05259.
8. Shi W, Kohler T, Zusman DR. Chemotaxis plays a role in the social behavior of Myxococcusxanthus. Mol Microbiol. 1993; 9: 601-611. doi: 10.1111/j.1365-2958.1993.tb01720.x
9. Shi W, Bogdanov M, Dowhan W, Zusman DR. The pss and psd genes are required for motility and chemotaxis in Escherichia coli. J Bacteriol. 1993; 175: 7711-7714.
10. Shi W, Kohler T, Zusman DR. Isolation and phenotypic characterization of Myxococcusxanthus mutants which are defective in sensing negative stimuli. J Bacteriol. 1994; 176: 696-701.
11. Shi W, Zusman DR. Sensory adaptation during negative chemotaxisin Myxococcusxanthus. J Bacteriol. 1994; 176: 1517-1520.
12. Shi W, Kohler T, Zusman DR. Motility and chemotaxis in Myxococcusxanthus. Methods in Molecular Genetics. 1994; 3: 258-269.
13. Shi W, Zusman DR. Sensor/response in Myxococcusxanthus to attractants and repellents requires the frz signal transduction system. Res Microbiol. 1994; 145: 431-435. doi: 10.1016/0923-2508(94)90091-4
14. Acuna G, Shi WK. Trudeau and Zusman DR. The “CheA” and “CheY” domains of MyxococcusxanthusFrzE function independently in vitro as a kinase and a phosphotase, respectively. FEBS letters. 1995; 358: 31-33. doi: http://dx.doi.org/10.1016/0014-5793(94)01389-I
15. Shi W, Zusman DR. Methionine inhibits developmental aggregation of Myxococcusxanthus by blocking the biosynthesis of S-adenosyl methionine. J Bacteriol. 1995; 177: 5346-5349.
16. Shi W, Stocker BAD, Adler J. Effect of the surface composition of motile Escherichia coli and motile Salmonella species on the direction of galvanotaxis. J Bacteriol. 1996; 178: 1113-1119.
17. Shi W, Zusman DR. Cell density dependent cellular reversal frequency controls the fruiting body formation. Proc Natl Acad Sci USA. 1996; 93: 4142-4146.
18. Han YW, Shi W. Developing genetic tools to study oral bacterial pathogenesis. Internat J Oral Biol. 1997; 22: 13-20.
19. Yang Z, Geng Y, Shi W. A DnaK homolog in Myxococcusxanthus is involved in social motility and fruiting body formation. J Bacteriol. 1998; 180: 218-224.
20. Shi W, Yang Z, Geng Y, Wolinsky LE, Lovett M. Chemotaxis in Borreliaburgdorferi. J Bacteriol. 1998; 180: 231-235.
21. Geng Y, Yang Z, Downard J, Zusman D, Shi W. Methylation of FrzCD defines a discrete step in the developmental program of Myxococcusxanthus. J Bacteriol. 1998; 180: 5765-5768.
22. Shi W, Jewett A, Hume WR. Rapid and quantitative detection of Streptococcus mutans with species-specific monoclonal antibodies. Hybridoma. 1998; 17: 365-371.
23. Yang Z, Geng Y, Xu D, Kaplan H, Shi W. A new set of chemotaxis homologs is essential for Myxococcusxanthus social motility. Mol Microbiol. 1998; 30: 1123-1130. doi: 10.1046/j.1365-2958.1998.01160.x
24. Han YW, Uhl MA, Han SJ, Shi W. Expression of bvgas of Bordetella pertussis represses flagellar biosynthesis of Escherichia coli. Arch Microbiol. 1999; 171: 127-130.
25. Hong S, Yang Z, Shi W. Effect of Cellular Filamentation on adventurous and social gliding motility of Myxococcusxanthus. Proc Natl Acad Sci USA. 1999; 96: 15178-15183. doi: 10.1073/pnas.96.26.15178
26. Jewett A, Hume WR, Le H, et al. Induction of apoptotic cell death in peripheral blood mononuclear cells and polymorphonuclear cells by an oral bacterium Fusobacteriumnucleatum. Infect Immun. 2000; 68: 1893-1898. doi: 10.1128/IAI.68.4.1893-1898.2000
27. Yang Z, Guo F, Bowden MG, Tong L, Kaplan HB, Shi W. The MyxococcusxanthuswbgB gene encodes a glycosyltransferase homologue required for lipopolysaccharide O-antigen biosynthesis. Arch Microbiol. 2000; 174: 399-405.
28. Yang Z, Ma X, Tong L, Kaplan HB, Shimkets LJ, Shi W. Myxococcusxanthusdif genes are required for biosynthesis of cell surface fibrils essential for social motility. J Bacteriol. 2000; 182: 5793-5798.
29. Tsai JP, Shi W. Analysis of gene expression in Treponemadenticola with differential display PCR. Oral Microbiol Immun. 2000; 15: 305-308.
30. Hong S, Zusman D, Shi W. Type IV pilus of Myxococcusxanthus is a motility apparatus controlled by the frzchemotaxis homologs. Current Biology. 2000; 10: 1143-1146. doi: http://dx.doi.org/10.1016/S0960-9822(00)00705-3
31. Han YW, Shi W, Huang G, et al. Interactions between periodontal bacteria and human oral epithelial cells: Fusobacteriumnucleatum adheres to and invades epithelial cells. Infect Immun. 2000; 68: 3140-3146. doi: 10.1128/IAI.68.6.3140-3146.2000
32. Lux R, Moter A, Shi W. Chemotaxis in pathogenic spirochetes: directed movement toward targeting tissues? J Mol Microbiol Biotechnol. 2000; 2: 355-364.
33. Shi W, Yang Z, Sun H, Lancero H, Tong L. Phenotypic analyses of frz and dif double mutants of Myxococcusxanthus. FEMS Microbiology Letters. 2000; 192: 211-215.
34. Merritt J, Anderson M, Park NH, Shi W. Bacterial biofilm and dentistry. CDA Journal. 2001; 29: 355-360.
35. Sun H, Shi W. Genetic studies of mrp, a locus essential for cellular aggregation and sporulation of Myxococcusxanthus. J Bacteriol. 2001; 183: 4786-4795.
36. Chen L, Ma L, Park NH, Shi W. Cariogenic actinomyces identified with a beta-glucosidase dependent green color reaction to Gardenia jasminoides extract. J Clin Microbiol. 2001; 39: 3009-3012.
37. Lux R, Miller JN, Park NH, Shi W. Tissue penetration of oral epithelial cell layers by Treponemadenticola is motility and chemotaxis dependent. Infect Immun. 2001; 69: 6276-6283. doi: 10.1128/IAI.69.10.6276-6283.2001
38. Sun H, Shi W. Analyses of mrp genes during Myxococcusxanthus development. J Bacteriol. 2001; 183: 6733-6739.
39. Shi W, Sun H. Type IV pili dependent motility and its possible role in bacterial pathogenesis. Infect and Immun. 2002; 70: 1-4. doi: 10.1128/IAI.70.1.1-4.2002
40. Lancero H, Brofft JE, Downard J, et al. Mapping of Myxococcusxanthus social motility dsp mutations to the difgenes. J Bacteriol. 2002; 184: 1462-1465.
41. Lux R, Sim J-H, Tsai JP, Shi W. Construction and characterization of a cheA mutant of Treponemadenticola. J Bacteriol. 2002; 184: 3130-3134.
42. Gu F, Lux R, Anderson MH, et al. Analyses of Streptococcus mutans in saliva with species-specific monoclonal antibodies. Hybridoma and Hybridomics. 2002; 21: 225-232. doi: 10.1089/153685902760213822.
43. Bellenger K, Ma X, Shi W, Yang Z. A cheW homologue is required for Myxococcusxanthus fruiting body development, social gliding motility, fibril biogenesis. J Bacteriol. 2002; 184: 5654-5660.
44. Gu F, Ma X, Lux R, Shi W. Production and characterization of species-specific monoclonal antibodies against Actinomycesnaeslundii and Lactobacillus case i. Hybridoma and Hybridomics. 2002; 21: 469-478. doi: 10.1089/153685902321044007
45. Merritt J, Qi F, Goodman S, Anderson MH, Shi W. Mutation of luxS affects biofilm formation in Streptococcus mutans. Infect and Immun. 2003; 71: 1972-1979. doi: 10.1128/IAI.71.4.1972-1979.2003
46. Li Y, Sun H, Ma X, et al. Extracellular polysacchrides mediate pilus retraction during social motility of Myxococcusxanthus. Proc Natl Acad Sci USA. 2003; 100: 5443-5448. doi: 10.1073/pnas.0836639100
47. Wang Y, Shi W, Chen W, Chen C. Type IV pilus homologs pilABCD are required for the natural transformation in Actinobacillusactinomycetemcomitans. Gene. 2003; 312: 249-255. doi: 10.1016/S0378-1119(03)00620-6
48. Qi F, Merritt J, Lux R, Shi W. Inactivation of the ciaH Gene in Streptococcus mutans Diminishes Mutacin Production and Competence Development, Alters Sucrose-Dependent Biofilm Formation, Reduces Stress Tolerance. Infect Immun. 2004; 72: 4795-4899. doi: 10.1128/IAI.72.8.4895-4899.2004
49. Kreth J, Merritt J, Bordador C, Shi W, Qi F. Transcriptional analysis of mutacin I (mutA) gene expression in planktonic and biofilm cells of Streptococcus mutansusing fluorescent protein and glucuronidase reporters. Oral Microbiol Immun. 2004; 19: 252-256. doi: 10.1111/j.1399-302X.2004.00148.x
50. Lux R, Shi W. Chemotaxis guided movements in bacteria. Critical Rev. Oral Biol Med. 2004; 15: 207-220. doi: 10.1177/154411130401500404
51. Li Y, Zhou X, Ho C-M, et al. Interleukin 6 and interleukin 8 as potential biomarkers for oral cavity and oropharyngeal squamous cell carcinoma. Arch Otolaryngol Head Neck Surg. 2004; 130: 929-935. doi: 10.1001/archotol.130.8.929
52. Lancero H, Caberoy NB, Castaned S, et al. Characterization of a Myxococcusxanthus mutant that is defective for adventurous motility and social motility. Microbiology. 2004; 150: 4085-4093. doi: 10.1099/mic.0.27381-0
53. Kreth J, Hagerman E, Tam K, et al. Quantitative analysis of Streptococcus mutans biofilms with quartz crystal microbalance, microjet impingement and confocal microscopy. Biofilms 2004; 1: 277-284. doi: 10.1017/S1479050504001516
54. Lux R, Li Y, Lu A, Shi W. Detailed three-dimensional analysis of structural features of Myxococcusxanthus fruiting bodies using confocal laser scanning microscopy. Biofilms. 2004; 1: 293-303.
55. Lu A, Cho K, Duan X, et al. Exopolysaccharide biosynthesis genes required for social motility in Myxococcusxanthus. Mol Microbiol. 2005; 55: 206-220. doi: 10.1111/j.1365-2958.2004.04369.x
56. Merritt J, Qi F, Shi W. A unique nine-gene comY operon in Streptococcus mutans. Microbiology. 2005; 151: 157-166. doi: 10.1099/mic.0.27554-0
57. Li Y, Pelling AE, Lux R, Gimzewski JK, Shi W. Analysis of type IV pilus and its associated motility in Myxococcusxanthususing an antibody reactive with native pilin and pili. Microbiology. 2005; 151: 353-360. doi: 10.1099/mic.0.27614-0
58. Li Y, Bustamante VH, Lux R, Zusman DR, Shi W. Divergent regulatory pathways control A- and S-motility in Myxococcusxanthus through FrzE, a CheA-CheY fusion protein. J Bacteriol. 2005; 187: 1716-1723.
59. Lancero H, Castaned S, Caberoy NB, Ma X, Garza AG, Shi W. Analyzing protein-protein interactions of the MyxococcusxanthusDif signaling pathway using yeast two-hybrid system. Microbiology. 2005; 151: 1535-1541.
60. Merritt J, Kreth J, Qi F, Sullivan R, Shi W. Non-disruptive, real time analysis of the metabolic status and viability of Streptococcus mutans cells in response to anti-microbial treatments. J Microbiol Methods. 2005; 61: 161-170. doi: 10.1016/j.mimet.2004.11.012
61. Pelling AE, Li Y, Shi W, Gimzewski JK. Nanoscale visualization and characterization of Myxococcusxanthuscells with atomic force microscopy. Proc Natl Acad Sci USA. 2005; 102: 6484-6489. doi: 10.1073/pnas.0501207102
62. Sim J-H, Shi W, Lux R. Protein-protein interactions in the chemotaxis signaling pathway of Treponemadenticola. Microbiology. 2005; 151: 1801-1807. doi: 10.1099/mic.0.27622-0
63. Gu F, Lux R, Du-Thumm L, et al. In situ and non-invasive detection of specific bacterial species in oral biofilms using fluorescently labeled monoclonal antibodies. J Microbiol Meth. 2005; 62: 145-160. doi: 10.1016/j.mimet.2005.02.013
64. Kreth J, Merritt J, Shi W, Qi F. Coordinated bacteriocin production and competence development: A possible mechanism for uptaking DNA from neighboring species. Mol Microbiol. 2005; 57: 392-404. doi: 10.1111/j.1365-2958.2005.04695.x
65. Merritt J, Kreth J, Shi W, Qi F. LuxS controls bacteriocin production in Streptococcus mutans through a novel regulatory output. Mol Microbiol. 2005; 57: 960-969. doi: 10.1111/j.1365-2958.2005.04733.x
66. St John MAR, Li Y, Zhou X, et al. Interleukin 6 and interleukin 8 as potential biomarkers for oral cavity and oropharyngeal squamous cell carcinoma. Arch Otolaryngol Head Neck Surg. 2004; 130: 929-935. doi: 10.1001/archotol.130.8.929
67. Chen L, Chen X, Ma L, et al. Inhibition of Growth of Streptococcus mutans, Methicillin-Resistant Staplhylococcusaureus, Vancomycin-Resistant Enterococci by Kurarinone, a Bioactive Flavonoid Isolated from Sophoraflavescens. J Clin Microbiol. 2005; 43: 3574-3575. doi: < 10.1128/JCM.43.7.3574-3575.2005/a>
68. Kaplan C, Lux R, Huynh T, Jewett A, Shi W, Haake SK. Fusobacteriumnucleatum apoptosis inducing outer membrane protein. J Dent Res. 2005; 84: 700-704. doi:
10.1177/154405910508400803
69. Kreth J, Merritt J, Shi W, Qi F. Competition and co-existence between Streptococcus mutans and Streptococcussanguinis in the dental biofilm. J Bacteriol. 2005; 187: 7193-7203.
70. Qi F, Kreth J, Levesque C, et al. Peptide pheromone Induced Cell Death of Streptococcus mutans. FEMS Microbiology Lett. 2005; 251: 321-326.
71. Li Y, Denny C-M, Ho C, et al. The oral fluid MEMS/NEMS chip (OFMNC): Diagnostic and translational applications. J Dent Res. 2005; 18: 3-5. doi: 10.1177/154407370501800102
72. Lux R, Shi W. A novel bacterial signaling system with a combination of a Ser/Thr kinase cascade and a His/Asp two-component system. Mol Microbiol. 2005; 58: 345-348. doi: 10.1111/j.1365-2958.2005.04856.x
73. Yang C, Brooks E, Li Y, et al. Detection of picomolar levels of interleukin-8 in human saliva by SPR. Lab Chip. 2005; 5: 1017-1023. doi: 10.1039/B504737D
74. Tsang , Merritt J, Nguyen T, Shi W, Qi F. Identification of genes associated with mutacin I production in Streptococcus mutans using random insertional mutagenesis. Microbiology. 2005; 151: 3947-3955. doi: 10.1099/mic.0.28221-0
75. Nguyen T, Tsang, Shi W and Qi F. Dental caries and chemical warfare within the mouth. Journal of CDA. 2005; 33: 947-950.
76. Fung A, Yang CY, Freire S, et al. Fluorescent detection of oral pathogens by a solid-phase immunoassay on PDMS. ConfProc IEEE Eng Med Biol Soc. 2005; 3: 2630-2633. doi: 10.1109/IEMBS.2005.1617009
77. Cross SE, Kreth J, Zhu L, et al. Atomic force microscopy study of the structure-function relationships of the biofilm-forming bacterium Streptococcus mutans. Nanotechnology. 2006; 7: S1-S7. doi: 10.1088/0957-4484/17/4/001.
78. Pelling AE, Li Y, Castaned S, Shi W, Gimzewski JK. Self-organized and highly ordered domain structures within swarms of Myxococcusxanthus. Cell Motil Cytoskeleton. 2006; 63: 141-148. doi: 10.1002/cm.20112
79. Massoth D, Massoth G, Massoth IR, et al. The effect of xylitol on Streptococcus mutans in children. J Calif Dent Assoc. 2006; 34: 231-234.
80. Merritt J, Qi F, Shi W. Milk helps to build strong teeth and to promote oral health for life. J Calif Dent Assoc. 2006; 34: 361-366.
81. He J, Chen L, Heber D, Shi W, Lu Q-Y. Antibacterial compounds from Glycyrrhizauralensis. J Nat Prod. 2006; 69: 121-124. doi: 10.1021/np058069d
82. Eckert R, Qi F, Yarbrough DK, et al. Adding selectivity to antimicrobial peptides: rational design of a multidomain peptide against Pseudomonas spp. Antimicrob Agents Chemother. 2006; 50: 1480-1488. doi: 10.1128/AAC.50.4.1480-1488.2006
83. Anderson M H, Shi W. A probiotic approach to caries management. Pediatric dentistry. 2006; 28: 151-153.
84. Tsang , Qi F, Shi W. Medical approach to dental caries: fight the disease, not the lesion. Pediatric dentistry. 2006; 28: 188-191.
85. Tsang , Merritt J, Shi W, Qi F. IrvA-dependent and IrvA-independent pathways for mutacin gene regulation in Streptococcus mutans. FEMS Microbiol Lett. 2006; 261: 231-234. doi: 10.1111/j.1574-6968.2006.00351.x
86. Zhu L, Kreth J, Cross SE, Gimzeski JK, Shi W, Qi F. Functional characterization of cell-wall-associated protein WapA in Streptococcus mutans. Microbiology. 2006; 152: 2395-2404. doi: 10.1099/mic.0.28883-0
87. Eckert R, Brady KM, Greenberg EP, et al. Enhancement of antimicrobial activity against Pseudomonas aeruginosa by coadministration of G10KHc and tobramycin. Antimicrob Agents Chemother. 2006; 50: 3833-3838. doi: 10.1128/AAC.00509-06
88. Tsang , Qi F, Huwig AK, Anderson MH, Wesley D, Shi W. A medical approach to the diagnosis and treatment of dental caries. AHIP Cover. 2006; 47: 38-42.
89. Eckert R, He J, Yarbrough DK, Qi F, Anderson MH, Shi W. Targeted killing of Streptococcus mutans by a pheromone-guided "smart" antimicrobial peptide. Antimicrob Agents Chemother. 2006; 50: 3651-3657. doi: 10.1128/AAC.00622-06
90. Tong H, Zhu N, Chen W, Qi F, Shi W, Dong X. Establishing a genetic system for ecological studies of Streptococcus oligofermentans. FEMS Microbiol Lett. 2006; 264: 213-219. doi: 10.1111/j.1574-6968.2006.00453.x
91. Gu F, Qi F, Anderson MH, Shi W. Comparative analysis of a monoclonal antibody-based Streptococcus mutans detection method with selective culture assays using polymerase chain reaction as a gold standard. Hybridoma. 2006; 25: 372-377. doi: 10.1089/hyb.2006.25.372
92. Kreth J, Merritt J, Zhu L, Shi W, Qi F. Cell density- and come-dependent expression of a group of mutacin and mutacin-like genes in Streptococcus mutans. FEMS Microbiol Lett. 2006; 265: 11-17. doi: 10.1111/j.1574-6968.2006.00459.x
93. Chariva M, Cao N, Le K, et al. b-D-Allose inhibits fruiting body formation and sporulation in Myxococcusxanthus. J Bacteriol. 2007; 189: 169-178.
94. Chalmers N I, Palmer RJ, Jr Du-Thumm L, et al. Use of quantum dot luminescent probes to achieve single cell resolution of human oral bacteria in biofilms. Appl Environ Microbiol. 2007; 73: 630-636. doi: 10.1128/AEM.02164-06
95. Tong H, Chen W, Merritt J, Qi F, Shi W, Dong X. Streptococcus oligofermentans inhibits Streptococcus mutans through conversion of lactic acid into inhibitory H2O2: a possible counteroffenstive strategy for interspecies competition. Mol Microbiol. 2007; 63: 872-880. doi: 10.1111/j.1365-2958.2006.05546.x
96. Shi W, Lux R. Focal adhesion – getting a grasp on myxobacterial gliding. Nature Chemical Biology. 2007; 3: 205-206. doi: 10.1038/nchembio0407-205
97. He J, Eckert R, Pharm T, et al. Novel synthetic antimicrobial peptides against Streptococcus mutans. Antimicrob. Agents Chemother. 2007; 51: 1351-1358. doi: 10.1128/AAC.01270-06
98. Merritt J, Tsang, Zheng L, Shi W, Qi F. Construction of a counterselection based in frame deletion system for genetic studies of Streptococcus mutans. Oral Microbiol Immunol. 2007; 22: 95-102. doi: 10.1111/j.1399-302X.2007.00329.x
99. Merritt J, Zheng L, Shi W, Qi F. Genetic characterization of the hdrRM operon: a novel high-cell-density-responsive regulator in Streptococcus mutans. Microbiology. 2007; 153: 2765-2773. doi: 10.1099/mic.0.2007/007468-0
100. Kreth J, Hung DC, Merritt J, et al. The response regulator ComE in Streptococcus mutans functions both as a transcription activator of mutacin production and repressor of CSP biosynthesis. Microbiology. 2007; 153: 1799-1807. doi: 10.1099/mic.0.2007/005975-0
101. Tam K, Kinsinger N, Ayala, Qi F, Shi W, Myung NV. Real-time monitoring of Streptococcus mutans biofilm formation using a quartz crystal microbalance. Caries Research. 2007; 41: 474-483. doi: 10.1159/000108321
102. Cross SE, Kreth J, Zhu L, et al. Nanomechanical properties of glucans and associated cell-surface adhesion of Streptococcus mutans probed by atomic force microscopy under in situ conditions. Microbiology. 2007; 153: 3124-3132. doi: 10.1099/mic.0.2007/007625-0
103. Eckert R, McHardy I, Yarbrough DK, et al. Stability and activity in sputum of G10KHc, a potent anti-Pseudomonas antimicrobial peptide. Chem Biol Drug Des. 2007; 70: 456-460. doi: 10.1111/j.1747-0285.2007.00580.x
104. Kuramitsu H K, He X, Lux R, Anderson MH, Shi W. Interspecies interactions within oral microbial communities. Microbiol Mol Biol Rev. 2007; 71: 653-670. doi: 10.1128/MMBR.00024-07
105. Kreth J, Kim D, Nguyen M, et al. The antimicrobial effect of silver ion impregnation into endodontic sealer against Streptococcus mutans. The Open Dentistry Journal. 2008; 2: 18-23. doi: 10.2174/1874210600802010018
106. Kreth J, Zhu L, Merritt J, Shi W, Qi F. Role of sucrose in the fitness of Streptococcus mutans. Oral Microbiol Immunol. 2008; 23: 213-219. doi: 10.1111/j.1399-302X.2007.00413.x.
107. Ruby JD, Lux R, Shi W, Charon NW, Dasanayake A. Effect of glucose on Treponemadenticola cell behavior. Oral Microbiol Immunol. 2008; 23: 234-238. doi: 10.1111/j.1399-302X.2007.00417.x.
108. Tong H, Chen Wg, Shi W, Qi F, Dong X. SO-LAAO, a novel L-amino acid oxidase that enables Streptococcus oligofermentans to outcomepeteStreptococcus mutans by generating H2O2 from peptone. J Bacteriol. 2008; 190: 4716-4721. doi: 10.1128/JB.00363-08
109. He X, Wu C, Yarbrough D, et al. The ciaoperon of Streptococcus mutans encodes a unique component required for calcium-mediated authoregulation. Mol Microbiol. 2008; 70: 112-126. doi: 10.1111/j.1365-2958.2008.06390.x.
110. Kaplan CW, Lux R, Haake SK, Shi W. The Fusobacteriumnucleatumouter membrane protein RadD is an arginine-inhibitableaddhesin required for inter-species adherence and the structured architecture of multispecies biofilm. Mol Microbiol. 2009; 71: 35-47. doi: 10.1111/j.1365-2958.2008.06503.x
111. Palsdottir H, Remis JP, Schaudinn C, et al. Three-dimensional macromolecular organization of cryofixedMyxococcusxanthus biofilms as revealed by electron microscopic tomography. J Bacteriol. 2009; 191: 2077-2082.
112. He J, Eckert R, Anderson MH, Shi W. Design and activity of a "dual-targeted" antimicrobial peptide. Int J of Antimicrob Agents. 2009; 33: 532-537. doi: 10.1016/j.ijantimicag.2008.11.013
113. Hsu CC, Chung HY, Hagerman EM, et al. Effects of hardness and elastic modulus for DSS-8 peptide treatment on remineralization of human dental tissues. Mate Res Soc Symp Proc. 2009; 1132: Z09-05. doi: 10.1557/PROC-1132-Z09-05.
114. Nguyen T, Zhang Z, Huang IH, et al. Genes involved in the repression of mutacin I production in Streptococcus mutans. Microbiology. 2009; 155: 551-556. doi: 10.1099/mic.0.021303-0.
115. Gu F, Li Y, Zhou C, et al. Bacterial 16S rRNA/rDNA profiling in the liquid phase of human saliva. Open Dent J. 2009; 3: 80-84.
116. He X, Shi W. Oral microbiology: Past: resent and future. Int J Oral Sci. 2009; 1: 47-58. doi: 10.4248/ijos.09029
117. Nguyen T, Zhang Z, Huang IH, et al. Genes involved in the repression of mutacin I production in Streptococcus mutans. Microbiology. 2009; 155: 551-556. doi: 10.1099/mic.0.021303-0
118. He X, Lux R, Kuramitsu HK, Anderson MH, Shi W. Achieving probiotic effects via modulating oral microbial ecology. Advances in dental research. 2009; 21: 53-56. doi: 10.1177/0895937409335626
119. Cross SE, Kreth J, Wali RP, Sullivan R, Shi W, Gimzewski JK. Evaluation of bacteria-induced enamel demineralization using optical profilometry. Dent Mater. 2009; 25: 1517-1526. doi: 10.1016/j.dental.2009.07.012
120. Sondej M, Denny A, Xie Y, et al. Glycoprofiling of the human salivary proteome. Clin Proteomics. 2009; 5: 52-68 doi: 10.1007/s12014-008-9021-0
121. Black WP, Xu Q, Cadieux CL, Suh SJ, Shi W, Yang Z. Isolation and characterization of a suppressor mutation that restores Myxococcusxanthusexopolysaccharide production. Microbiology. 2009; 155: 3599-3610. doi: 10.1099/mic.0.031070-0
122. Li L, He J, Eckert R, et al. Design and characterization of an acid-activated antimicrobial peptide. ChemBiol Drug Des. 2010; 75: 127-132. doi: 10.1111/j.1747-0285.2009.00904.x
123. Yarbrough DK, Hagerman E, Eckert R, et al. Specific binding and mineralization of calcified surfaces by small peptides. Calcif Tissue Int. 2010; 86: 58-66. doi: 10.1007/s00223-009-9312-0
124. Liu F, Shi W, Zhu W. Vaccination targeting surface FomA of Fusobacteriumnucleatum against bacterial co-aggregation: Implication for treatment of periodontal infection and halitosis. Vaccine. 2010; 28: 3496-3505. doi: 10.1016/j.vaccine.2010.02.047
125. Li L, Guo L, Lux R, et al. Targeted antimicrobial therapy against Streptococcusmutans establishes protective non-cariogenic oral biofilms and reduced subsequent infection. Int J Oral Sci. 2010; 2: 66-73. doi: 10.4248/IJOS10024.
126. Yang Z, Lux R, Hu W, Hu C, Shi W. PilA localization affects extracellular polysaccharide production and fruiting body formation in Myxococcusxanthus. Mol Micro. 2010; 76: 1500-1513. doi: 10.1111/j.1365-2958.2010.07180.x.
127. Li L, Finnegan MB, Özkan S, et al. In vitro study of biofilm formation and effectiveness of antimicrobial treatment on various dental material surfaces. Mol Oral Microbiol. 2010; 25: 384-90. doi: 10.1111/j.2041-1014.2010.00586.x.
128. Pan C, Harper S, Ricci-Nittel D, Lux R, Shi W. In-vitro evidence for efficacy of antimicrobial mouthrinses. J Dent. 2010; 38(Suppl 1): S16-20. doi: 10.1016/S0300-5712(10)70006-3.
129. He J, Yarbrough DK, Kreth J, Anderson MH, Shi W, Eckert R. Systematic approach to optimizing specifically targeted antimicrobial peptides against Streptococcus mutans. Antimicrob Agents Chemother. 2010; 54: 2143-2151. doi: 10.1128/AAC.01391-09
130. Shi W, Zhou X. Interspecies interactions within human oral microbial communities. West China J Stomatol. 2010; 28: 1-4. doi: 10.1128/MMBR.00024-07
131. Zhou X, Shi W. Human oral microbiome and plaque biofilms. West China J of Stomatol. 2010; 28: 115-118.
132. Li L, Kim Y, Su Y, et al. Evaluation of different cleansers for their efficacy against Candida biofilm on denture surfaces. Int J of Oral Med. 2010; 37: 157-160.
133. He X, Yan T, Lux R, McLean J, Yu G, Shi W. Using DGGE profiling to develop a novel culture medium suitable for oral microbial communities. Mol Oral Microbiol. 2010; 25: 357-67. doi: 10.1111/j.2041-1014.2010.00585.x.
134. He X, Yan T, Guo L, Lux R, Zusman DR, Shi W. In vitro communities derived from oral and gut microbial floras inhibit the growth of bacteria of foreign origins. Microb Ecol. 2010; 60: 665-76. doi: 10.1007/s00248-010-9711-9.
135. He X, Yan T, Guo L, Lux R, Zusman DR, Shi W. Oral-derived bacterial flora defends its domain by recognizing and killing intruders-a molecular analysis using Escherichia coli as a model intestinal bacterium. Microb Ecol. 2010; 60: 655-64. doi: 10.1007/s00248-010-9708-4
136. Mchardy I, Keegan V, Sim JH, Shi W, Lux R. Transcriptional profiles of Treponemadenticola in response to environmental conditions. PLoS One. 2010; 5: e13655. doi: 10.1371/journal.pone.0013655.
137. Kaplan CW, Ma X, Aranjpe A, et al. Fusobacteriumnucleatum outer membrane proteins Fap2 and RadD induce cell death in human lymphocytes. Infect Immun. 2010; 78: 4773-4778. doi: 10.1128/IAI.00567-10.
138. Hsu CC, Chung HY, Yang JM, Shi W, Wu B. Influence of 8DSS Peptide on Nano-mechanical Behavior of Human Enamel. J Dent Res. 2010; 90: 88-92. doi: 10.1177/0022034510381904
139. Hu C, He J, Eckert R, et al. Development and Evaluation of a safe and effective sugar-free herbal lollipop that kills cavity-causing bacteria. Int J Oral Sci. 2011; 3: 13-20. doi: 10.4248/IJOS11005.
140. Hu W, Hossain M, Lux R, et al. Exopolysaccharide-independent sociall motility of Myxococcus Xanthus. PLoS One. 2011; 6: e16102. doi: 10.1371/journal.pone.0016102.
141. Wang J, Hu W, Lux R, He X, Li Y, Shi W. Natural transformation of Myxocuccus Xanthus. J Bacteriol. 2011; 193: 2122-32. doi: 10.1128/JB.00041-11
142. Wang R, He X, Hu W, et al. Analysis of interspecies adherence of oral bacteria using a membrane binding assay coupled with polymerase chain reaction-denaturing gradient gel electrophoresis profiling. Int J Oral Sci. 2011; 3: 90-97. doi: 10.4248/IJOS11033.
143. Zhe Y, Hu W, Chen K, et al. Alanine 32 in PilA is important for PilA stability and type IV pili function in Myxococcus Xanthus. Microbiology. 2011; 157: 1920-1928. doi: 10.1099/mic.0.049684-0.
144. Hung DC, Downey JS, Ayala EA, et al. Characterization of DNA Binding Sites of the ComE Response Regulator from Streptococcus mutans. J Bacteriol. 2011; 193: 3642-3652. doi: 10.1128/JB.00155-11
145. Kaplan CW, Sim JH, Shah KR, et al. Selective Membrane Disruption: Mode of Action of C16G2, a Specifically Targeted Antimicrobial Peptide. Antimicrob Agents Chemother. 2011; 55: 3446-52. doi: 10.1128/AAC.00342-11
146. Qu X, Wang M, Shi W, Zhou X. Analysis of the Chinese Dental Insurance Development. West China J Stomatol. 2011; 29: 106-110. doi: 10.3969/j.issn.1000-1182.2011.01.027
147. Hendrata M, Yang Z, Lux R, Shi W. Experimentally guided computational model discovers important elements for social behavior in Myxobacteria. PLoS One. 2011; 6. doi: 10.1371/journal.pone.0022169
148. Chugal N, Wang JK, Wang R, et al. Molecular characterization of the microbial flora residing at the apical portion of infected root canals of human teeth. J Endod. 2011; 37: 1359-64. doi: 10.1016/j.joen.2011.06.020
149. Yarbrough DK, He j, Hagerman E, et al. Rapid probing of biological surfaces with a sparse-matrix peptide library. PLoS One. 2011; 6: e23551. doi: 10.1371/journal.pone.0023551
150. Sullivan R, Santarpia, Lavender S, et al. Clinical efficacy of a specifically targeted antimicrobial peptide mouth rinse: targeted elimination of streptococcus mutans and prevention of demineralization. Caries Res. 2011; 45: 415-28. doi: 10.1159/000330510
151. Huynh T, Kapur RB, Kaplan CW, et al. The role of aggregation in Fusobacteriumnucleatum-induced immune cell death. J Endod. 2011; 37: 1531-5. doi: 10.1016/j.joen.2011.06.034
152. He X, Hu W, Guo L, Lux R, Shi W. Community-based interference against integration of Pseudomonas aeruginosa into human salivary microbial biofilm. Mol Oral Microbiolo. 2011; 26: 337-52. doi: 10.1111/j.2041-1014.2011.00622.x
153. Hu W, Yang Z, Lux R, et al. Direct visualization of the interaction between pilin and exopolysaccharides of Myxococcus Xanthus with eGFP-fused PilA protein. FEMS MicrobiolLett. 2011; 326: 23-30. doi: 10.1111/j.1574-6968.2011.02430.x.
154. Cao Y, Zhou X, Shi W. New progress in research of Granulicatella species. Hua Xi Kou Qiang Yi XueZaZhi. 2011; 29: 665-9. doi: 10.3969/j.issn.1000-1182.2011.06.027
155. He X, Hu W, Kaplan C, Guo L, Shi W, Lux R. Adherence to Streptococci facilitates Fusobacteriumnucleatum integration into into an oral microbial community. Microbial Ecology. 2012; 63: 532-42. doi: 10.1007/s00248-011-9989-2.
156. Kaplan A, Wang R, Lux R, Shi W, He X. The influence of iron availability on the composition of human salivary microbial community. Microb Ecol. 2012; 64: 152-61. doi: 10.1007/s00248-012-0013-2
157. Hu W, Wang J, McHardy I, et al. Effects of Exopolysaccharide Production on Liquid Vegetative Growth, Stress Survival and Stationary Phase Recovery in Myxococcus Xanthus. J Microbiol. 2012; 50: 241-8. doi: 10.1007/s12275-012-1349-5
158. Zhang G, Zhang F, Ding G, et al. Acyl homoserine lactone-based quorum sensing in a methanogenicarchaeon. ISME. 2012; 6: 1336-44.
159. Hung DC, Downey JS, Kreth J, et al. Oligomerization of the response regulator ComE from Streptococcus mutans is affected by phosphorylation. J Bacteriol. 2012; 194: 1127-35. doi: 10.1128/JB.06565-11
160. McLean JS, Fansler SJ, Majors D, et al. Identifying low pH active and Lactate-utilizing taxa within oral microbiome communities from healthy children using stable isotope probing techniques. PLoS One. 2012; 7: e32219. doi: 10.1371/journal.pone.0032219
161. Eckert R, Sullivan R, Shi W. Targeted antimicrobial treatment to re-establish a healthy microbial flora for long-term protection. Adv Dent Res. 2012; 24: 94-7. doi: 10.1177/0022034512453725.
162. Pan H, Luan J, He X, Lux R, Shi W. The ClpB gene is involved in the stress response of Myxococcus Xanthus during vegetative growth and development. Microbiology. 2012; 158: 2326-43. doi: 10.1099/mic.0.060103-0.
163. Hu W, Li L, Sharma S, et al. DNA builds and strengthens the extracellular matrix in Myxococcusxanthus biofilms by interacting with exopolysaccharides. Plos One. 2012; 7(12): e51905. doi: 10.1371/journal.pone.0051905
164. Hu W, Lux R, Shi W. Analysis of Exopolysaccharides in Myxococcus Xanthus using confocal laser sacanning microscopy. Methods in Molecular Biology. 2013; 966: 121-31. doi: 10.1007/978-1-62703-245-2_8.
165. Guo L, Shi W. Salivary biomarkers for caries risk assessment. J Calif Dent Assoc. 2013; 41: 107-118.
166. Guo L, Hu W, He X, Lux R, McLean J, Shi W. Investigating Acid Production by treptococcus mutans with a Surface-Displayed pH-Sensitive Green Fluorescent Protein. PLoS One. 2013; 8(2): e57182. doi: 10.1371/journal.pone.0057182
167. Guo L, Wu t, Hu W, et al. Phenotypic characterization of the foldase homologue PrsA in Streptococcus mutans. Mol Oral Microbiol. 2013; 28: 154-65. doi: 10.1111/omi.12014
168. Gibiansky ML, Hu W, Dahmen KA, Shi W, Wong GC. Earthquake-like dynamics in Myxococcusxanthus social motility. PNAS-USA. 2013; 110: 2330-5. doi: 10.1073/pnas.1215089110
169. Wu T, Hu W, Guo L, et al. Development of a new model system to study microbial colonization on denture. J Prosthodont. 2013; 22(5): 344-50. doi: 10.1111/jopr.12002
170. Zheng X, Zhang K, Zhou X, et al. Involvement of gshAB in the Interspecies Competition within Oral Biofilm. J Dent Res. 2013; 92(9): 819-24. doi: 10.1177/0022034513498598
171. Pan H, He X, Lux R, Luan J, Shi W. Killing of Escherichia coli by Myxococcusxanthus in Aqueous Enviorments Requires Exopolysaccharide-Dependent Physical Contact. Microb Ecol. 2013; 66(3): 630-8. doi: 10.1007/s00248-013-0252-x
172. Le S, He X, Tan Y, et al. Mapping the tail fiber as the receptor binding protein responsible for differential host specificity of Pseudomonas aeruginosa bacteriophages PaP1 and JG004. PLoS One. 2013; 8(7): e68562. doi: 10.1371/journal.pone.0068562
173. Lillehoj PB, Kaplan CW, He J, Shi W, Ho CM. Rapid, Electrical Impedance Detection of Bacterial Pathogens Using Immobilized Antimicrobial Peptides. J Lab Autom. 2014; 19(1): 42-9 doi: 10.1177/2211068213495207
174. He X, McLean JS, Guo L, Lux R, Shi W. The social structure of microbial community involved in colonization resistance. ISME J. 2014; 8(3): 564-74. doi: 10.1038/ismej.2013.172
175. Edlund A, Yang Y, Hall AP, et al. An in vitro biofilm model system maintaining a highly reproducible species and metabolic diversity approaching that of the human oral microbiome. Microbiome. 2013; 1(1): 25. doi: 10.1186/2049-2618-1-25
176. Le S, Yao X, Lu S, et al. Chromosomal DNA deletion confers phage resistance to Pseudomonas aeruginosa. Sce Rep. 2014; 4: 4738. doi: 10.1038/srep04738
177. Guo L, He X, Shi W. Intercellular communications in multispecies oral microbial communities. Front Microbiol. 2014. doi: 10.3389/fmicb.2014.00328
178. Kaplan A, Kaplan CW, He X, McHardy I, Shi W, Lux R. Characterization of aid1, a novel gene involved in Fusobacteriumnucleatum interspecies interactions. Microb Ecol. 2014. doi: 10.1007/s00248-014-0400-y
179. Wang Y, Xue J, Zhou X, et al. Oral microbiota distinguishes acute lymphoblastic leukemia pediatric hosts from healthy populations. PLoS One. 2014; 9(7): e102116. doi: 10.1371/journal.pone.0102116
180. Sarkar J, McHardy IH, Simanian EJ, Shi W, Lux R. Transcriptional responses of Treponemadenticola to other oral bacterial species. 2014; 9(2): e88361. doi: 10.1371/journal.pone.0088361
181. Tu Q, He Z, Li Y, et al. Development of HuMichip for functional profiling of human microbiomes. PLoS One. 2014; 9(3): e90546. doi: 10.1371/journal.pone.0090546
182. Li Y, He J, He Z, et al. Phylogenetic and functional gene structure shifts of the oral microbiomes in periodontitis patients. ISME J. 2014. doi: 10.1038/ismej.2014.28
183. Sharma S, Lavender S, Woo J, et al. Nanoscale characterization of effect of L-arginine on S. mutans biofilm adhesion by Atomic Force Microscopy. Microbiology. 2014. doi: 10.1099/mic.0.075267-0
184. Xu X, He J, Xue J, et al. Oral cavity contains distinct niches with dynamic microbial communities. Environ Microbiol. 2014. doi: 10.1111/1462-2920.12502.
185. Yang Y, Lv XP, Shi W, et al. 8 DSS-Promoted Remineralization of Initial Enamel Caries in Vitro. J Dent Res. 2014; 93(5): 520-524. doi: 10.1177/0022034514522815.

David Earl Simmons, DDS

Assistant Professor
Department of Periodontics
LSUHSC - School of Dentistry
1100 Florida Avenue Box 138
New Orleans, Louisiana 70119, USA

BiographyResearch InterestScientific ActivitiesPublications
EDUCATION:

•(1963) Professional School: Loyola of the SouthSchool of Dentistry, New Orleans, Louisiana, D.D.S. Degree


MILITARY SERVICE:

•(1960-1967) United States Navy - Lieutenant JR Dental Corps


EMPLOYMENT

PRIVATE PRACTICE/ WORK EXPERIENCE:

•(1998-Present) Faculty -Louisiana State University School of Dentistry
•(1965-1998) Private Practice New Orleans Louisiana


ACADEMIC APPOINTMENTS:

•(2005-Present) Assistant Professor of Clinical Periodontics
•(2002-2005) Clinical Assistant Professor of Periodontics
•(2001-2002) Instructor, Dental Morphology –RDH
•(1998-2001) Instructor/Department of Prosthodontics

His research interest include: Periodontics.

MEMBERSHIPS AND OFFICES

•(1963) American Dental Association Life Member from
•(1963) Louisiana Dental Association, Life Member from Past Vice-president
•(1963) New Orleans Dental Association Life Member from New Orleans Conference Chairman 1978
•(1987) International College of Dentists
•(1979-2002)American Academy of Esthetic Dentistry, Director 1983-1986
•(1984-1989) Louisiana State Board of Dentistry; President 1988-1989
•(1984-1989) National Association of Dental Examiners
•(1977) Co-founder National Conference of Dental Meetings
•(2013-Present) American Academy of Dental Research Member

1. Maney P, Simmons D, Kee E. Reliability of Soft Tissue Model Based Implant Surgical Guides. Journal of Oral Implantology. 2012; 38(6): 723-727.

Federico Foschi, PhD, FHEA

Program Director Endodontics MSc
Kings College London - Dental Institute
Strand, London WC2R 2LS, UK

BiographyResearch InterestScientific ActivitiesPublications

Dr. Foschi is the Endodontics MSc Program Director at the Kings College London. He graduated cum laude at the Alma Mater Studiorum, University of Bologna. He accomplished a Ph.D. in Endodontic Microbiology awarded by the University of Bologna, in collaboration, as visiting student fellow, with The Forsyth Institute, Harvard University in Boston. He subsequently carried out a postdoctoral program in Photodynamic Therapy applied to Endodontics. He completed a five-year training in Restorative Dentistry (Prosthodontics, Periodontology and Endodontology) at Kings College London. He is registered as Endodontic specialist in UK. He maintains active clinical practice limited to Endodontics. He is member of the British Endodontic Society. He received the Pulp Biology Award. He acts as referee for several endodontic journals.

His research interests include: Microscopic aspect of root canal dentine following shaping, endodontic microbiology, photodynamic therapy and means to eradicate endodontic biofilms.

MEMBERSHIPS:

• Member of the British Endodontic Society


AWARDS:

• Pulp Biology Award

1. Prati C, Foschi F, Nucci C, Montebugnoli L, Marchionni S. Appearance of the root canal walls after preparation with NiTi rotary instruments: a comparative SEM investigation. Clin Oral Investig. 2004; 2: 102-110. doi:10.1007/s00784-004-0253-8
2. Foschi F, Nucci C, Montebugnoli L, et al. SEM evaluation of canal wall dentine following use of Mtwo and ProTaper NiTi rotary instruments. Int Endod J. 2004; 12: 832-839. doi: 10.1111/j.1365-2591.2004.00887.x
3. Foschi F, Nucci C, Marchionni S, Prati C. Ultrastruttura della Dentina Trattata Endodonticamente. Italian Journal of Operative Dentistry. 2004; 2: 21-28.
4. Marangoni A, Sambri V, Cavrini F, et al. Treponema denticola infection is not a cause of false positive Treponema pallidum serology. New Microbiol. 2005; 28: 215-221.
5. Cavrini F, Sambri V, Moter A, et al. Molecular detection of Treponema denticola and Porphyromonas gingivalis in carotid and aortic atheromatous plaques by FISH: report of two cases. J Med Microbiol. 2005; 54: 93-96. doi: 10.1099/jmm.0.45845-0
6. Foschi F, Cavrini F, Montebugnoli L, Stashenko P, Sambri V, Prati C. Detection of bacteria in endodontic samples by polymerase chain reaction assays and association with defined clinical signs in Italian patients. Oral Microbiol Immunol. 2005; 5: 289-295. doi: 10.1111/j.1399-302X.2005.00227.x
7. Pirani C, Chersoni S, Foschi F, et al. Does hybridization of intraradicular dentin really improve fiber post retention in endodontically treated teeth? J Endod. 2005; 12: 891-894.
8. Foschi F, Izard J, Sasaki H, et al. Treponema denticola in disseminating endodontic infections. J Dent Res. 2006; 85: 761-765. doi:10.1177/154405910608500814
9. Soukos NS, Chen PS, Morris JT, et al. Photodynamic therapy for endodontic disinfection. J Endod. 2006; 32: 979-984. doi: http://dx.doi.org/10.1016/j.joen.2006.04.007
10. Foschi F, Fontana CR, Ruggiero K, et al. Photodynamic inactivation of Enterococcus faecalis in dental root canals in vitro. Lasers Surg Med. 2007; 39: 782-787. doi: 10.1002/lsm.20579
11. Cavrini F, Pirani C, Foschi F, Montebugnoli L, Sambri V, Prati C. Detection of Treponema denticola in root canal systems in primary and secondary endodontic infections. A correlation with clinical symptoms. New Microbiol. 2008; 31: 67-73.
12. Pirani C, Bertacci A, Cavrini F, et al. Recovery of Enterococcus faecalis in root canal lumen of patients with primary and secondary endodontic lesions. New Microbiol. 2008; 31: 235-240.
13. Fimple JL, Fontana CR, Foschi F, et al. Photodynamic treatment of endodontic polymicrobial infection in vitro. J Endod. 2008; 34: 728-734. doi:10.1016/j.joen.2008.03.011
14. Pagonis TC, Chen J, Fontana CR, et al. Nanoparticle-based endodontic antimicrobial photodynamic therapy. J Endod. 2010; 36: 322-328. doi: 10.1016/j.joen.2009.10.011
15. Foschi F, Conserva E, Pera P, Canciani B, Cancedda R, Mastrogiacomo M. Graft Materials and Bone Marrow Stromal Cells in Bone Tissue Engineering. J Biomater Appl. 2011; 1-14. doi: 10.1177/0885328210393046
16. De Carlo B, Sauro S, Deb S, et al. Porosity, Micro-Hardness and Morphology of White and Gray Portland Cements in Relation to Their Potential in the Development of New Dental Filling Materials. J Adhesion Science Tech. 2011; 1-8.
17. Sauro S, Di Renzo S, Castagnola R, et al. Comparison between water and ethanol wet bonding of resin composite to root canal dentin. Am J Dent. 2011; 24(1): 25-30.

Otto Lok Tao Lam, BSc, BDS, PhD

Clinical Assistant Professor
Oral Rehabilitation of the Faculty of Dentistry
The University of Hong Kong
Pokfulam, Hong Kong, China

BiographyResearch InterestScientific ActivitiesPublications

Dr. Lam received his PhD from Oral Rehabilitation, Faculty of Dentistry, The University of Hong Kong (HKU). He also previously received his BDS at HKU, and his BSc (microbiology) at The University of Victoria, British Columbia, Canada. He is currently a Clinical Assistant Professor at the Faculty of Dentistry, HKU, and his research interests include oral rehabilitation of patients following stroke, geriatric dentistry, and oral microbiology of medically compromised patients. He is currently engaged in research studies involving oral health promotion interventions among patients following stroke, and elders under long- term institutional care.

His research interests include: Cerebrovascular disease, gerodontology, oral microbiology, oral health promotion.

AWARDS:

•(2011) International Association for Dental Research - Lion Dental Research Award for Junior Investigators
•(2012) Postgraduate Research Output Prize (Faculty of Dentistry, HKU)

1. Lam OL, Zhang W, Samaranayake LP, Li LS, McGrath C. A systematic review of the effectiveness of oral health promotion activities among patients with cardiovascular disease. International journal of cardiology. 2011; 151(3): 261-267. doi: 10.1016/j.ijcard.2010.11.014.
2. Lam OL, McGrath C, Li LS, Samaranayake LP. Effectiveness of oral hygiene interventions against oral and oropharyngeal reservoirs of aerobic and facultatively anaerobic gram-negative bacilli. American journal of infection control. 2012; 40(2): 175-182. doi: 10.1016/j.ajic.2011.03.004.
3. Lam OL, McGrath C, Bandara HM, Li LS, Samaranayake LP. Oral health promotion interventions on oral reservoirs of Staphylococcus aureus: a systematic review. Oral diseases. 2012; 18(3): 244-254. doi: 10.1111/j.1601-0825.2011.01874.x.
4. Lam OL, Bandara HM, Samaranayake LP, McGrath C, Li LS. Oral health promotion interventions on oral yeast in hospitalised and medically compromised patients: a systematic review. Mycoses. 2012; 55(2): 123-142. doi: 10.1111/j.1439-0507.2011.02062.x.
5. Lam OL, McMillan AS, Samaranayake LP, Li LS, McGrath C. Effect of oral hygiene interventions on opportunistic pathogens in patients after stroke. American journal of infection control. 2012; 40: 175-182. doi:10.1016/j.ajic.2012.02.020.
6. Bandara HM, Lam OL, Watt RM, Jin LJ, Samaranayake LP. Bacterial lipopolysaccharides variably modulate in vitro biofilm formation of Candida species. Journal of Medical Microbiology. 2010; 59(Pt 10): 1225-1234. doi: 10.1099/jmm.0.021832-0.
7. McGrath C, Lam O, Lang N. An evidence-based review of patient-reported outcome measures in dental implant research among dentate subjects. Journal of clinical periodontology. 2012; 39(Suppl 12): 193-201. doi: 10.1111/j.1600-051X.2011.01841.x.
8. Bandara HM, Lam OL, Jin LJ, Samaranayake L. Microbial chemical signaling: a current perspective. Critical reviews in microbiology. 2012; 38(3): 217-249. doi: 10.3109/1040841X.2011.652065
9. Lam OL, McMillan AS, Samaranayake LP, Li LS, McGrath C. Randomized clinical trial of oral health promotion interventions among patients following stroke. Archives of Physical Medicine and Rehabilitation. 2013; 94: 435-443. doi: 10.1016/j.apmr.2012.10.024
10. Lam OL, McMillan AS, Samaranayake LP, Li LS, McGrath C. Predictors of oral health-related quality of life in patients following stroke. Journal of Rehabilitation Medicine. 2014; 46(5): 520-526. doi: 10.2340/16501977-1806
11. Dai R, Lam OL, Lo ECM, Li LSW, Wen Y, McGrath C. A systematic review and meta-analysis of clinical, microbiological, and behavioural aspects of oral health among patients with stroke. Journal of Dentistry. 2014. doi: 10.1016/j.jdent.2014.06.005.
12. Dai R, Lam OL, Lo ECM, Li LSW, Wen Y, McGrath C. Orofacial functional impairments among patients following stroke: a systematic review. Oral Diseases. 2014. doi: 10.1111/odi.12274
13. Chen Z, Feng S, Pow EH, Lam OL, Mai S, Wang H. Organic anion composition of human whole saliva as determined by ion chromatography. Clinica Chimica Acta. 2014; 438C: 231-235. doi: 10.1016/j.cca.2014.08.027

Ismael Khouly, DDS, MS, PhD

Diplomate, International Congress of Oral Implantologists
Clinical Assistant Professor, Department of Oral and Maxillofacial Surgery
Clinical Research Coordinator, Bluestone Center for Clinical Research
NYU College of Dentistry
421 First Avenue, 2nd Floor
New York, NY 10010-4086, USA

BiographyResearch InterestScientific ActivitiesPublications

Dr. Khouly is currently a Clinical Assistant Professor in the Department of Oral and Maxillofacial Surgery and clinical research coordinator and investigator at the Bluestone Center for Clinical Research at New York College of Dentistry (NYUCD). He received his DDS from Spain from the University of Granada, College of Dentistry, and he also spent some time studying at the dental institutes of the University of Oslo, Norway and Queen Marys University of London in the United Kingdom. After receiving the DDS, he obtained a Masters Degree in Tissue Engineering from the School of Medicine at the University of Granada. Then he relocated his career path to the United States and completed a three-year advanced program in implant and comprehensive dentistry at NYUCD. In addition to that, he received his PhD in Biomedicine (sinus augmentation using growth factors and collagen membranes) and International Doctorate Certification from University of Granada School of Medicine in Granada and NYUCD in 2013. He has several years of research experience and he has been involved in several randomized clinical trials, systematic reviews, and case reports, mainly in periodontics, implant dentistry and oral cancer. He is currently reviewer for the Journal of Periodontology.

His research interests include peridontology, implant and aesthetic dentistry.

MEMBERSHIPS

• International Congress of Oral Implantologists
• American Academy of Periodontology


VOLUNTEER PROFESSIONAL EXPERIENCE

•(2009) OUTREACH in Ruinas de Copan- General Dentistry. Honduras. (New York University College Of Dentistry)
•(2007) OUTREACH in Chihuahua General Dentistry. University of Chihuahua, Mexico


SERVICE ACTIVITIES/FACULTY RESEARCH MENTORING

•(2014-Present) CTSI Mentor Development Program, New York University School of Medicine
•(2013-Present) Clinical Research Mentoring, Bluestone Center for Clinical Research, New York University College of Dentistry

1. Garcia P, Khouly I, Loomer P. Effectiveness of systemic antimicrobial therapy in combination with scaling and root planing compared with therapy based on only scaling and root planing in the treatment of periodontitis: A systematic review. 2014.
2. Froum ST, Cho SC, Khouly I, et al. The Use of a Xenogeneic Collagen Matrix as a Soft Tissue Graft at the time of Implant Placement to Thicken Soft Tissue Buccal to the Implant. 2014.
3. Khouly I,Froum SJ, Gallego D, Khouly S, Cho SC. Treatment Options for the Atrophic Posterior Maxilla. J Act Med. 2014.
4. Froum SJ, Cho SC, Rosenberg E, et al. Radiographic Comparison of Different Concentrations of Recombinant Human Bone Morphogenetic Protein with Allogenic Bone Compared to the Use of 100% Mineralized Cancellous Bone Allograft in Maxillary Sinus Grafting. Int J Periodontics Restorative Dent. 2014.
5. Froum SJ, Cho SC, Wallace S, et al. Histomorphometric Comparison of Different Concentrations of Recombinant Human Bone Morphogenetic Protein with Allogenic Bone Compared to the Use of 100% Mineralized Cancellous Bone Allograft in Maxillary Sinus Grafting. Int J Periodontics Restorative Dent. 2013; 33(6): 721-730.
6. Froum SJ, Wallace S, Cho SC, et al. A Histomorphometric Comparison of Bio-Oss Alone Versus Bio-Oss and Platelet-Derived Growth Factor for Sinus Augmentation: A Postsurgical Assessment. Int J Periodontics Restorative Dent. 2013; 33(3): 269-279.
7. Froum S, Khouly I, Favero G, Cho SC. Effect of Maxillary Sinus Membrane Perforation of Vital Bone Formation. J Periodontol. 2013; 84(8): 1094-1099.
8. Khouly I, Froum SJ, Munoz C. A Human Histologic and Radiographic Report of a Spontaneous Bone Formation Without Bone Graft After Reentry of Sinus Floor Augmentation. 2013.
9. Khouly I, Froum SJ, Katz M, Corby P. Challenges to Recruitment of a Randomized Clinical Trial Using Bilateral Dental Implants. 2013.
10. Pardinas S, Froum SJ, Khouly I. Histological and Histomorphometrical analysis of biopsy haversted 10 years after maxillary sinus floor augmentation with deproteinized bovine and PRGF. 2013.
11. Floriano PN, Kerr AR, Schmidt BL, et al. Results of a 950-patient phase 2/3 clinical characteriz ation-as sociation study to classify patients with Potentially Malignant Oral Disorders (PMODs) using a non-invasive Lab-On-a -Chip (LOC) approach. J Oral Oncology. 2013; 49: S70-S70.
12. Khouly I, Froum S, Wright L, Cho SC. Complications in Maxillary Sinus Augmentation Procedures That May Lead To Sinus Reentry. 2013.
13. Froum S, Cho SC, Cayarga R, Khouly I. Osteotome-Assited Sinus Augmentation Procedure for Single Implant Palcement in the Atrophic Posterior Maxilla. Dental Learning. 2012;
14. Khouly S, Gonzalez-Costa V, Khouly I, de la Cruz J. Introduccion a la filosofia de MTB. Ortodoncia Espanola. 2011; 51(1): 17-23.
15. Khouly I, Brook J, Cho SC, Froum S, Bloom M. New Surgical Approach for Implant Placement In Atrophic Posterior Maxillary. Post Graduate Resident Research in Periodontics and Implant Dentistry. New York, USA: New York University College of Dentistry, Research Day; 2011.
16. Wright L, Khouly I, Cho SC, Elian N, Froum S, Tarnow DP. The Sinus Lift Complications. Post Graduate Resident Research in Periodontics and Implant Dentistry. New York, USA: New York University College of Dentistry, Research Day; 2010.

Daniel Kazachkov, DMD

Dental Arts of Westwood
Dentist Serving Westwood
Needham, Dedham, Norwood, MA, USA

BiographyResearch InterestScientific ActivitiesPublications
EDUCATION

• (2004-2008) D.M.D. degree Tufts University School of Dental Medicine
• (2000-2004) 4 year accelerated Biology/Chemistry program with BS in Biology with honors - University of Massachusetts


WORK EXPERIENCE & PROFESSIONAL DEVELOPMENT

•(2014-Present) Dental Arts of Westwood, Dentist Serving Westwood, Needham, Dedham, Norwood, MA, USA
•(2013-2014) Boston University School of Dental Medicine Restorative Faculty teaching students
•(2010-Present) Advanced Dentistry at Dental Arts of Westwood as Owner and Sole Proprietor, performing general dentistry, advanced cosmetic/prosthetic dentistry and the full scope of Oral Surgery and Endodontic Procedures.
•(2011-Present) General Dentistry Oral Surgery and Endodontics at International Place Dental Associates
•(2010-Present) General Dentistry Oral Surgery and Endodontics at All Smiles Dental Inc. in Lowell, MA where I developed a large referral base
•(2008-2010) General Dentistry at Family Dental with cosmetic dentistry and a developed Endodontics and Oral Surgery referral base as well as impacted wisdom tooth removal.
•(2008-2009) General Dentistry at Gentle Dental with experience in Prosthodontics, Endodontics, Operative Dentistry and Oral Surgery
•(2007-2008) Student Teacher in the Tufts Dental Lab TA program for Paula Callahan
•Implantology Fellow from the American Dental implant Association run by Dr. Arun Garg from The Miami Implant Institute
•Volunteer work at Native American Reservations in Arizona doing dentistry in the desert.
To know more about Dr. Kazachkov, please visit his personal website:
http://www.dentalartsofwestwood.com/Meet_The_Dentist.html

His research interests include: General Dentistry, Oral Surgery and Pharmacology

CONTINUING EDUCATION AND RESEARCH: (OVER 300 C.E. HOURS)

•(2012) Opioid Prescribing Course mandated by Mass Dental Board along with all Clinical Emergency classes mandated by the dental board for the new equirements and an ACTIVE Massachusetts License
•(2014) CPR Certification through
• Fellow and Member of the American Dental Implant Association with 120 CE course classroom hours attained through continuum course with Dr. Arun Garg and additional didactic experience of placement abroad
• Dr. Frank Spears esthetics in crown and bridge and Veneer work on Ant. and Posterior teeth
• Dr. Lowe’s restorative dentistry seminars and the utilization of stain to give natural dentition
• Course on H1N1 Virus awareness and its methods of potential spread in a dental environment
• Extensive Endodontic CE courses with Dr. Buchanan, with focus on multiple areas; including retreats, apicoectomies, and vertical condensation
• Extensive Oral Surgery courses in Wisdom tooth impactions and possible complications, frenectomies, bone grafting and flap design
•(2001-2004) Organic Chemistry Lab at the University of Massachusetts working with highly reactive metals and metalloids, and the effects of inert gases on the control of highly unstable reactions, in order to determine ideal conditions for synthesis of new, more stable and controlled reactions. Dr. Adams of the Organic Chemistry Honors Department
•(2001-2004) Microbiology Lab at the University of Massachusetts studying the mutations responsible for the antibiotic resistance of Staph. aureus (MARS) and the effects of antibiotic overuse in modern medicinal treatments Under Dr. Brian O’Connor of the Biology Department


ACCOMPLISHMENTS, HONORS & AWARDS:

• Graduate of Tufts University School of Dental Medicine with a High Endodontic, Prosthodontic, and Operative grades of 90% and above
• Graduate of the Commonwealth Honors College from the University of Massachusetts
• 8 Semesters of Deans List Honors with State recognition for excellence in education
• WREB Certification with an 89.3% total score
•(2014 and 2015) Won best of Westwood Massachusetts 2 years running now

1. Kazachkov D. You still use dycal? Dent Open J. 2015; 2(1): e1-e2. doi: 10.17140/DOJ_2_e00l
2. Kazachkov D. Implantology have forever changed dentistry. Dent Open J. 2015; 2(4): e5-e7. doi: 10.17140/DOJ_2_e003

Boyd E. Robinson, DDS, MEd

Interim Dean
Universitiy of Florida College of Dentistry
PO Box 100412
Gainesville, FL 32610, USA

BiographyResearch InterestScientific ActivitiesPublications

Dr. Robinson is a Clinical Associate Professor and currently the Interim Dean University of Florida College of Dentistry. He is a graduate of the University of the Pacific, School of Dentistry. He comes to the University of Florida after serving 26 years in the United States Navy. During his active duty time in the Navy he received a certificate in Comprehensive Dentistry from the Naval Postgraduate Dental School.
His Navy career afforded him many opportunities. He had the distinct honor to be the dentist to the President of the United States. He served for both President Reagan and Bush (senior). He also had several leadership roles as Director of the Naval Postgraduate Dental School and as Commanding Officer of the Naval Dental Center Northeast. He spent time at sea aboard the aircraft carrier, USS Carl Vinson and with the Marines at Camp Pendleton, California.
Dr. Robinson is a Diplomate and past President of the Federal Services Board of General Dentistry, and a Diplomate to the American College of General Dentistry. He is a fellow of the International College of Dentists, American College of Dentists, and the Academy of General Dentistry. He is currently on the editorial board for the Journal of Operative Dentistry.
Dr. Robinson is married to the former Janis Marie Poppin.

His research interests include: Restorative dentistry and Clinical practice.

VOLUNTEER

• (2006 –Present)- Alachua County Organization for Rural Needs Board Member, president elect of the board
• (2006, 2007, 2008)- Lead a team of Students (21-26) to Honduras for a dental mission trip (Christian Dental Society)
• (2005 - Present)- Amazon Vision Ministries, Board of Directors
• (2003 -Present)- We Care Clinic, Santa Fe Community College
• (2003, 2004, 2005)- Minority Mentor Program (Univ. of Florida)
• (1997 -1998)- Church Interim Youth Minister
• (1989 -1990)- Church -Chair Personnel Committee
• (1986)- Medical/Dental Mission
• Hospital de la Familia
• Nuevo Progresso, Guatemala


PROFESSIONAL LECTURES/PRESENTATIONS/COURSE DIRECTOR

• Course Director for:
• DEN7017 & DEN8018 Professionalism in Patient Care and Practice Management
• DEN8290 Dental Photographic and Imaging Techniques
• Treatment Planning “Essentials”, Presented to General Practice Residents, VA Hospital, Gainesville, FL Aug 2009.2010, 2011, 2012
• Treatment Planning “From School to Practice”, Presented to the Naval Dental Center Pensacolas Yearly Symposium, April 2008
• Treatment Planning “From School to Practice”, Integral Parts Seminar and Clinical Case Presentations. Naval Postgraduate Dental School, Bethesda, Maryland, May 2007
• Update on Dentistry and Ethics-Presented to the Montgomery-Bucks County Dental Association, Pennsylvania, January 2006
• Bleaching & Whitening; Cements, Bases and Liners; and Acid Etched Resin Bonded Bridges-Presented at the Naval Dental Center Pensacolas Yearly Symposium, April 2004
• Bleaching Agents-Presented to the Foreign Trained Dentist Program, UF College of Dentistry, October 2002
• Class V Preparations-Presented to the Foreign Trained Dentist Program, UF College of Dentistry, September 2002
• Acid Etched Resin Bonded Retainers-Presented to the Foreign Trained Dentist Program, UF College of Dentistry, March 2002
• Acid Etched Resin Bonded Retainers-Presented to the Advanced Education in General Dentistry Program, New London, February 2001.
• Educational Opportunities in the Navy and challenges in Higher Education in the future-Presented to the Tri-Service Dental Education Conference, January 1999.
• Developed and taught the Dental Ethics Course-Naval Postgraduate Dental School, 1997 -2000.
• A Competency Based Curriculum -Presented to Faculty Forum, August 1998.
• Resin Dentistry and whats new with glass ionomer cements -Presented to the Lafayette, LA Dental Society, May 1998.
• Bases, Cements and Liners -Presented to the Greater Charleston Dental Society, April 1992 and the Rappenhanock Dental Society, September 1992.
• Total Quality Management -Presented to the Operating Forces Management Seminar, April 1990 & 1991.
• Dentinal Bonding Agents -Presented to the Alpha Omega Dental Society, Washington, DC, March 1984.

Bapanaiah Penugonda, BDS, MS, FADM

Associate Professor
Group Practice Director
Department of Cariology and Comprehensive Care
New York University College of Dentistry
New York, USA

BiographyResearch InterestScientific ActivitiesPublications
EDUCATION

•(1985-1987) Advanced Study in Dentistry for Foreign Trained Dentists, New York University College of Dentistry, 345 East, 24th St, New York, New York 10010, USA
•(1980-1982) MS, Master of Science (Dental Materials Science), New York University Graduate School of Arts and Sciences, New York University College of Dentistry, New York, New York 10010, USA
•(1969-1974) BDS, Bachelor of Dental Surgery, Institute of Medical Sciences, Osmania Medical College
Hyderabad, India


PROFESSIONAL EXPERIENCE


PRIVATE PRACTICE

• (1987-Present) General & Cosmetic Dentistry, 19 West 44th Street, Suite 400, New York, New York 10036, USA
•(1977-1980) Dentist to the Government of Belize, General Dentistry, Belmopan, Belize, Central America
•(1977-1980) Private Practice, General Dentistry, Belmopan, Belize, Central America
•(1975-1977) Associate Dentist, General Dentistry, Hyderabad, Andhra Pradesh, India


HOSPITAL TRAINING

•Resident, General Dentistry, Institute of Medical Sciences, Osmania Medical College, Hyderabad, India
•(1974-1975) Rotations in Oral Surgery, Oral Diagnosis, Oral Radiology, Orthodontics, Endodontics, Operative Dentistry, Prosthodontics & Periodontics

His research interests include: Characterization of wear resistance of restorative materials, Active-passive anodic polarization behavior of palladium-based alloys, Metal-to-tooth resin cements.

HONORS AND AWARDS

•(1997-Present) Omicron Kappa Upsilon Dental Honor Society
•(1984-2002) Fellow Academy of Dental Materials – FADM


PROFESSIONAL SOCIETIES

•(1993-Present) President: Sigma Xi, The Scientific Research Society
•(1997-Present) Member: OKU Organizing Committee
•(1988-Present )Executive & Life Member: Indian Dental Association (USA)
•(1987-2006)Member: American Dental Association
•(1987-2006) Member: Dental Society of the State of New York
•(1987-2006) Member: First District Dental Society of the State of New York
•(1987-1997) Member: National Society of Dental Practitioners
•(1984-Present) Member: International Association for Dental Research
•(1984-Present) Member: American Association for Dental Research
•(1982-1996) Member: International Association for Calcified Tissue Research Group
•(1977-1980) Member: Belize Medical and Dental Association
•(1975-Present ) Life Member: Andhra Pradesh Dental Association, India

1. Congiusta M, Hyun D, Penugonda B. Papillion-Lefevre Syndrome: A Case Report. International Journal of Experimental Dental Science (IJEDS). 2013.
2. Penugonda B, Patel V, Patel A, Silver J, Congiusta M. Infection Control for Air-Borne Hazards-Masks and Respirators for Health Care Providers. Journal of the New York State Academy of General Dentistry Fall. 2011; 8.
3. Penugonda B, Kaplan J, Goddard G. Chronically Retained Acupuncture Needles Medical Acupuncture Journal. 2011; 23(2).
4. Penugonda B, Margulis M, Almas K. Contact Allergy to materials used in Dental practice; An update. Pakistan Oral and Dental Journal .2004; 24(1): 99-104.
5. Penugonda B, Margulis M. Allergy to Dental Materials. A Literature Review, 17th Annual Dental Convention, Souvenir Journal, Indian Dental Association(USA). 2001.
6. Penugonda B, Alhindi F. Glass Ionomer Cement.17th Annual Dental Convention, Souvenir Journal Indian Dental Association(USA). 2001.
7. Cohen B, Penugonda B. Use of inductively coupled plasma-emission spectroscopy and mercury vapor analyses to evaluate elemental release from a high-copper dental amalgam: A pilot study. The Journal of Prosthodontic Dentistry. 2001; 84(1): 409-412. doi: http://dx.doi.org/10.1067/mpr.2001.114013
8. Cohen B, Penugonda B, Pagnillo M K, Schulman A, and Hittelman E. EdD Torsional resistance of crowns cemented to composite core involving three stainless steel endodontic post designs. The Journal of Prosthodontic Dentistry.2000; 84(1): 38-42. doi: http://dx.doi.org/10.1067/mpr.2000.107915
9. Mantanaos S, Penugonda B. Use of custom plastic stent over periodontally compromised teeth to prevent extraction during final impressions for immediate dentures. 16th Annual Dental Convention, Souvenir Journal, Indian Dental Association (USA). 2000; 31-32.
10. Cohen B, Ph.D., Penugonda B, Pagnillo MK. Comparison of the Micro hardness of Five core buildup materials. Oral Health Journal, Canada. 1999; 25-33.
11. Settembrini L, Penugonda B, Scherer W, Strassler H, Hittelman E. Alcohol-containing Mouthwashes: Effect on Composite Color. Operative Dentistry. 1995; 20: 14-17.
12. Sullivan R J, Fletcher R, Bachman R, Penugonda B, LeGeros RZ. Intra-Oral Comparison and Evaluation of the Ability of Fluoride Dentifrices to Promote the Re-Mineralization of Caries-Like Lesions In Dentin And Enamel. Journal of Clinical Dentistry. 1995; 4.
13. Penugonda B. Review of Posterior Composite Resins.10th Annual Dental Convention, Souvenir Journal, Indian Dental Association. 1994.
14. Penugonda B, Settembrini L, Scherer W, Hittelman E, Strassler H. Alcohol-containing MouthWashes: Effect on Composite Hardness. The Journal of Clinical Dentistry. 1994; 5(2): 60-62.
15. Penugonda B, Fischer E. Dentifrice Abrasiveness on Microfill Composite Resin and Dentin: A Comparative Study. The Journal of Clinical Dentistry. 1993; 4(2): 55-60.
16. Stoner D, Scherer W, Loretta J, Penugonda B. Bonding Composite to Glass Ionomer with Adhesive Resin Cements. Journal of Esthetic Dentistry. 1992; 4: 13-15.
17. Scherer W, Penugonda B, Allan K, Ruiz M, Poveda C. Bonding Amalgam to Tooth Structure: A Scanning Electron Microscope Study. Journal of Esthetic Dentistry. 1992; 4: 199-210.
18. Cooper H, Scherer W, Penugonda B, Koifman V, Kokoletsos N. Bonding Porcelain to Nickel Chromium Alloy and Enamel. Esthetic Dentistry Update. 1992; 3(6): 40-141.
19. Penugonda B. Is Mercury Safe? And How Does It Affect the Dental Environment. 8th Annual Dental Convention, Souvenir Journal, Indian Dental Association (USA). 1992. 20. Penugonda B, Scherer W, Cooper H, Kokoletsos N, Koifman V. Bonding Ni-Cr Alloys to Tooth Structure with Adhesive Resin Cements. Journal of Esthetic Dentistry. 1992; (Suppl 4): 26-29.
21. Yankowitz D, Penugonda B, Meeker H. Evaluation of Endodontic Accomplishments of Students in the CCAPA Program.Journal of the Indian Dental Association. 1992; 63(9).
22. Kubota K, Golden B, Penugonda B. Root Canal Filling Materials for Primary Teeth: A Review of Literature. Journal of Dentistry for Children.1992; 59(3): 225-227.
23. Park K, Penugonda B. Pit and Fissure Sealant: Current Status.The New York State Dental Journal. 1992; 58(4): 27-29.
24. Scherer W, Penugonda B, Styner D, Georgescu M. At Home Vital Bleaching: Effects on Stained Enamel and Dentin. Practical Periodontics and Esthetic Dentistry. 1992; 4(2): 11-15.
25. Waknine S, Gable P, Penugonda B, Schulman A. Bond-Strength Characterization of an Experimental Series of Dentin Adhesives. Journal de Biomaterial Dentaire Annual. 1992; 5: 25-38.
26. Goldstein G, Barnhard B, Penugonda B. Profilometer, SEM, and Visual Assessment of Porcelain Polishing Methods. The Journal of Prosthetic Dentistry. 1991; 65(5): 628-634.
27. Zelnigher J, Ravinett S, Penugonda B. Mounting a Maxillary Cast Transversely Horizontal and Constructing a Plane of Occlusion Bilaterally Symmetrical. Compendium. 1990; 11(4): 194-206.
28. Scherer W, Kaim JM, Penugonda B, Ferretti A, Ehrlich B. Reinforced Glass Ionomer Cement vs. Zinc Phosphate Cement. An Interface Study: The New York State Dental Journal. 1990; 56(1): 19-20.
29. Zelnigher J, Penugonda B, Ravinett S. A Method to Identify and Correct Overextended Denture Borders. Compendium. 1989; 10(12): 678-680.
30. Vaidyanathan T K, Penugonda B, Shish K, Vaidyanathan K. Active Passive Anodic Polarization Behavior of Palladium Based Binary Alloys. Canadian Metallurgical Quarterly. 1986; 25: 123-129. doi: http://dx.doi.org/10.1016/S0109-5641(05)80039-9
31. LeGeros RZ, Penugonda B. Biomaterials for Alveolar Ridge Maintenance and Augmentation. New York State Dental Journal. 1983; 49(8): 570-575.

Joseph P. Graskemper, DDS, JD, DABMM

Associate Clinical Professor
Stonybrook School of Dental Medicine
General Practice Program (GPP)
State University of New York, School of Dental Medicine
Stony Brook, New York, USA

BiographyResearch InterestScientific ActivitiesPublications

Dr. Graskemper currently practices full-time in Bellport, New York. He graduated from Xavier University, attended Case Western Reserve Graduate School, obtained his dental degree from Ohio State University in 1977 and his law degree from Thomas Jefferson School of Law in San Diego, California in 1987. After dental school, where he was awarded a Navy Dental Scholarship, he was stationed at Camp Pendleton with the 1st Fleet Marine Division as a Lieutenant, U.S. Navy Dental Officer. He has been awarded Fellowships from the Academy of General Dentistry, American Endodontic Society, International Congress of Oral Implantologists, American Society of Osseointegration, and The American College of Legal Medicine. Recently, Dr Graskemper became a Diplomat in the American Board of Medical Malpractice.
Besides practicing dentistry full-time, he also is an Associate Clinical Professor in the 4th year General Practice Program at Stonybrook School of Dental Medicine, and teaches the Professionalism and Ethics in Dentistry course for residents and Dental Law at the 2nd, 3rd, and 4th year dental students. He was the past Director of Professional Responsibility courses and past Editor-in-Chief of the Stonybrook School of Dental Medicine GPR Literature Review Journal. Currently, he is the faculty advisor to the Student Professionalism and Ethics Association Club at Stonybrook. He belongs to many professional organizations and has served as a consultant to several state dental boards. He is a Board member of the International Dental Ethics and Law Society and the American Board of Medical Malpractice. Dr. Graskemper has authored many peer-reviewed articles, has lectured and published nationally and internationally. He recently published a book, “Professional Responsibility in Dentistry: A Guide to Law and Ethics”.
Prior to moving to Long Island to be closer to family, Dr. Graskemper was the previous sole owner of a fee-for-service multi-specialty group practice in La Jolla, California, having an Endodontist, Periodontist, Oral Surgeon, Prosthodontist, Orthodontist, Implantologist, and a General Dentist. He also was the President of Dentcom Advertising. While in California, he was also the owner of Sorrento Valley Ceramic Arts, a full service dental lab, and Chief of the Scripps Memorial Hospital Dental Staff.
He is very active in his community by being a Past President of the Patchogue Kiwanis Club, Past Chairman of the Board of Trustees of Maryhaven Center of Hope, a large Long Island wide agency serving the severely mentally and physically handicapped individuals of all ages. He currently is active in the Patchogue and the Bellport Chambers of Commerce; and, a past Chamber Member of the Year in Bellport. Recently, he was elected to the Board of Directors of the Suffolk County Dental Society.

His research interests includes: Professional Responsibility (Dental Law, Ethics, Professionalism), Risk Management, Practice Management, Oral Reconstruction/Rehabilitation.

HONORS

•(1975) Full Navy Scholarship for Dental School
•(1983) Fellowship – American Endodontic Society
•(1985) Fellowship – Academy of General Dentistry
•(1992) Fellowship – International Congress of Oral Implantologists
•(1992) Fellowship – American Society of Osseointegration
•(2007) Fellowship – American College of Legal Medicine, Diplomat – American Board of Medical Malpractice
•(2012) American College of Legal Medicine , Certificate of Distinction


PROFESSIONAL SERVICE OUTSIDE UNIVERSITY

•(1989-1992) Consultant to the California Board of Dental Examiners
•(1989-Present) Dental Consultant/Expert Witness
•(1996) Assist in identification of TWA Flight 800 victims
•(1996-1999) Suffolk County Dental Society, Speaker’s Bureau Committee
•(1996-Present) Consultant to dentists in practice transitions, transfers, and mentor students on professional career choices in pursuing dual degrees, practice location, associateships, and practice purchase.
•(1997-1999) Suffolk County Dental Society, Ethics Committee
•(1997-1999) Suffolk County, Young Dentists Committee
•(2005) Consultant to the Wisconsin Board of Dentistry
•(2010-Present) Suffolk County Dental Society Board of Directors
•(2012-Present) Suffolk County Dental Society Peer Review
•(2012-Present) American Board of Medical Malpractice Board of Directors
•(2012-Present) International Dental Law and Ethics Society Board of Directors
•(2013) Journal of Maxillofacial and Oral Surgery Editorial Board
•(2013) International Journal of Dental Science Editorial Board
•(2014) Austin Journal of Dentistry (Melbourne, Australia) Editorial Board


PROFESSIONAL SOCIETY MEMBERSHIP

•(1977-Present) American Dental Association
•(1977-Present) Academy of General Dentistry
•(1978-Present) American Endodontic Society
•(1979-1996) San Diego Dental Society
•(1979-1996) California Dental Association
•(1991-1996) American Academy of Implant Prosthodontics
•(1991-1996) International Congress of Oral Implantologists
•(1991-1996) American Society of Osseointegration
•(1996-Present) Suffolk County Dental Society, Board of Directors
•(1996-Present) New York State Dental Association
•(2006-Present) International Dental Ethics and Law Society, Board of Directors
•(2007-Present) American College of Legal Medicine
•(2007-Present) American Society for Dental Ethics
•(2007-Present) American Dental Educators Association
•(2014-Present) American College of Legal Medicine, Board of Directors

ORIGINAL ARTICLES

1. Graskemper JP. The wonderful world of independent contractors. Dental Economics. 1995; 85: 75-77, 79 - 83, 85: 75 – 77, 79 – 83, 85.
2. Graskemper JP. Setting up shop: employment status. Dentistry Today. 2000; 19(7): 49 - 53.
3. Graskemper JP. Starting/buying a practice. Dentistry Today. 2000; 19(8): 30 -33.
4. Graskemper JP. How to market a successful dental practice. Dentistry Today. 2000; 19(9): 28-31.
5. Graskemper JP. How to sell a treatment plan: co-diagnosing. Dentistry Today. 2000; 19(10): 41 - 43.
6. Graskemper JP. Employee management. Dentistry Today. 2000; 19(11): 36 -38.
7. Graskemper JP. Risk management. Dentistry Today. 2000; 19(12): 32 –37.
8. Graskemper JP. A new perspective on dental malpractice. The Journal of the American Dental association. 2002; 133(6): 752 – 757. doi: 10.14219/jada.archive.2002.0273
9. Graskemper JP. The standard of care in dentistry. The Journal of the American Dental Association. 2004; 35: 1449 - 1455.
10. Graskemper JP. Informed consent: a stepping stone in risk management. The Compendium. 2005; 26: 286 – 290.
11. Graskemper JP. Risk management 101, basic doctrines and definitions. Expert Series for Dentists.
Special Report website: http://www.berningaffiliates.com/.
12. Graskemper JP. Risk management 102, a primer on what to do to prevent a lawsuit. Expert Series for Dentists.
Special Report website: www.berningaffiliates.com.
13. Graskemper JP. Risk management 103, informed consent - how to do it right. Expert Series for Dentists.
Special Report website: www.berningaffiliates.com.
15. Graskemper JP. Risk management 104, the standard of care – what does it really mean. Expert Series for Dentists.
Special Report website: www.berningaffiliates.com.
16. Graskemper JP. Ethical advertising in dentistry. Journal of the American College of Dentists. 2009; 76( 1): 44 – 49.
17. Graskemper JP. The multi-specialty practice – how it began and you can do it too. Featured article DentistryIQ. com. 2009.
18. Graskemper JP. Dental Ethics with a New Emphasis: Reflections on the Curriculum. Bulletin of the International Dental Ethics and Law Society. 2009; 9(2): 38 - 40.
19. Graskemper JP. Ethics is how you respond to life. Journal of the American College of Dentists. 2011; 78( 3): 14 -17.
20. Graskemper JP. Professional responsibility in dentistry: what it is and how it works, Ethics in Biology; Engineering & Medicine. An International Journal. 2011; 2(2): 171-174 .
21. Graskemper JP. Elder abuse: time for dentists to be aware. Oral Health Journal. 2012; 14 -19.
22. Graskemper JP. Tips on how to improve your dental treatment consent form a legal perspective. Featured Article. 2013.
website: www.surgicalrestorative.com .

Rafael Arcesio Delgado-Ruiz, DDS, MSc, PhD

Assistant Professor
Prosthodontics and Digital Technology
1103 Westchester Hall
Stony Brook, NY 11794-8712, New York, USA

BiographyResearch InterestScientific ActivitiesPublications
HIGHER EDUCATION

• 1996- DDs, National University of Colombia, Bogotá, Colombia
• 1998- Specialist, Complutense University, Madrid, Spain, Specialist in Preventive Programs for the Oral Health at Public and Private Level
• 1999- Specialist, Oral Medicine, Complutense University, Madrid, Spain, Specialist in Oral Medicine
• 2000- Accreditation, Direction of Radio diagnosis Facilities, Cartagena, Spain, Director of Radio diagnosis Facilities
• 2007- Fellowship, Granada University, Granada, Spain, Animal Experimentation and Animal Research
• 2008- Postgraduate, Valencia University, Valencia, Spain, Prosthodontics
• 2009- PhD., Murcia University, Murcia, Spain Doctor of Philosophy, Summa Cum Laude
• 2011- MSc., Murcia University, Murcia, Spain, Implant Dentistry


PROFESSIONAL EXPERIENCE

CLINICAL

• 1996-1997 Chief of Oral Health Deparment, Health Department of Guainia, Colombia
• 1998-2012 Private Practice, focused on implant dentistry and implant prosthodontics, Spain


TEACHING

• 2007-2012 Associate Professor of Restorative Dentistry, Faculty of Medicine and Dentistry, Murcia University, Murcia, Spain
• 2007-2012 Associate Professor of Clinical Dentistry, Faculty of Medicine and Dentistry, Murcia University, Murcia, Spain
• 2009-2012 Assistant Professor of “Master in Clinical Dentistry, Implant Dentistry and Biomaterials”, Murcia University, Murcia, Spain.
• 2013-Present Assistant Professor, Prosthodontics and Digital Technology, Stony Brook University, New York, USA

His research interests includes: Biomaterials, Dental Implants, Bone substitutes, Cell Behavior, Zirconia and Melatonin as inductor of bone differentiation

HONORS

• 2013 First Prize, Best Scientific work, The Royal Academy of Medicine, Granada, Spain
• 2012 First Prize, Best Poster, EAO Meeting, Oslo, Norway
• 2011 First Prize, Research, The Royal Academy of Medicine and Surgery, Murcia, Spain
• 2010 First Prize, Poster, VII National Meeting, Spanish Society of Oral surgery
• 2010 Second Prize, Research, Best published paper, Dental Gazette, Madrid, Spain
• 2010 First Prize, Research, The Royal Academy of Medicine and Surgery, Murcia, Spain
• 2009 First Prize, Poster, Third International Congress of Bone Regeneration, Madrid, Spain
• 2008 First Prize, Oral Communications, Second International Congress of Bone Regeneration, Madrid, Spain
• 2007 First Prize, Clinical Case, First International Congress of Bone Regeneration, Madrid, Spain
• 2007 First Prize, Oral Communication, First International Congress of Bone Regeneration, Madrid, Spain
• 2007 First Prize, Oral Communication, Annual Meeting, Dental Research Center, Third Region, Valencia, Spain
• 1997 Governors Award, Guainía, Colombia

1. Orentlicher G, Horowitz A, Goldsmith D, Delgado-Ruiz R, Abboud M. Cumulative Survival Rate of Implants Placed Fully Guided Using CT-Guided Surgery: A 7-Year Retrospective Study. Compend Contin Educ Dent. 2014; 35(8): 590-597.
2. Calvo-Guirado JL, Maté-Sánchez JE, Delgado-Ruiz RA, Romanos GE, De Aza-Moya P, Velazquez P. Bone neo-formation and mineral degradation of 4Bone. Part II: histological and histomorphometric analysis in critical size defects in rabbits. 2014. doi: 10.1111/clr.12465
3. Calvo-Guirado JL, Aguilar Salvatierra A, Gargallo-Albiol J, Delgado-Ruiz RA, Mate Sanchez JE, Satorres-Nieto M. Zirconia with laser-modified microgrooved surface vs. titanium implants covered with melatonin stimulates bone formation. Experimental study in tibia rabbits. 2014. doi: 10.1111/clr.12472
4. Rafael Arcesio DR, Marcus A, Georgios R, Antonio AS, Gerardo GM, Jose Luis CG. Peri-implant bone organization surrounding zirconia-microgrooved surfaces circularly polarized light and confocal laser scanning microscopy study. Clin Oral Implant Res.2014. doi: 10.1111/clr.12461.
5. Calvo-Guirado JL, Aguilar-Salvatierra A, Gomez-Moreno G, Guardia J, Delgado-Ruiz RA. Mate-Sanchez de Val JE. Histological, radiological and histomorphometric evaluation of immediate vs. non-immediate loading of a zirconia implant with surface treatment in a dog model. Clin Oral Implant Res. 2014; 25(7): 826-30. doi: 10.1111/clr.12145
6. Calvo-Guirado JL, Satorres M, Negri B, et al. Biomechanical and histological evaluation of four different titanium implant surface modifications: an experimental study in the rabbit tibia. Clin Oral Investig. 2014; 18(5): 495-505. doi: 10.1007/s00784-013-1120-2
7. Delgado-Ruiz RA, Calvo-Guirado JL, et al. Porous titanium granules in critical size defects of rabbit tibia with or without membranes. Int J Oral Sci. 2014; 6(2): 105-110. doi: 10.1038/ijos.2014.6
8. Calvo-Guirado JL, Garces M, Delgado-Ruiz RA, Ramirez Fernandez MP, Ferres-Amat E, Romanos GE. Biphasic Beta-TCP mixed with silicon increases bone formation in critical site defects in rabbit calvaria. Clin Oral Implant Res. 2014. doi: 10.1111/clr.12413.
9. MatéSánchez de Val JE, CalvoGuirado JL, Delgado Ruiz RA, Gómez Moreno G, RamírezFernández MP, Romanos GE. Bone neo-formation and mineral degradation of 4Bone. Part I: material characterization and SEM study in critical size defects in rabbits. Clin Oral Implant Res. 2014. doi: 10.1111/clr.12420.
10. Fickl S, Fischer KR, Negri B, et al. Tissue response following papilla-sparing and sulcular incisions in oral surgery--an experimental study. Clin Oral Investig. 2014; 18(4): 1313-1317. doi: 10.1007/s00784-013-1069-1
11. Delgado-Ruiz RA, Calvo-Guirado JL, Romanos GE. Critical size defects for bone regeneration experiments in rabbit calvariae: systematic review and quality evaluation using ARRIVE guidelines. Clin Oral Implant Res. 2014. doi: 10.1111/clr.12406
12. Calvo-Guirado JL, Satorres-Nieto M, Aguilar-Salvatierra A, et al. Influence of surface treatment on osseointegration of dental implants: histological, histomorphometric and radiological analysis in vivo. Clin Oral Investig. 2014. doi: 10.1007/s00784-014-1241-2
13. Maté-Sánchez de Val JE, Mazón P, et al. Comparison of three hydroxyapatite/beta-tricalcium phosphate/collagen ceramic scaffolds: an in vivo study. J Biomed Mater Res A.2014; 102(4): 1037-1046. doi: 10.1002/jbm.a.34785.
14. Calvo-Guirado JL, López-López PJ, MatéSánchez de Val JE, Mareque-Bueno J, Delgado-Ruiz RA, Romanos GE. Influence of collar design on peri-implant tissue healing around immediate implants: A pilot study in Foxhound dogs. Clin Oral Implant Res. 2014. doi: 10.1111/clr.12374
15. Boquete-Castro A, Gómez-Moreno G, Aguilar-Salvatierra A, Delgado-Ruiz RA, Romanos GE, Calvo-Guirado JL. Influence of the implant design on osseointegration and crestal bone resorption of immediate implants: a histomorphometric study in dogs. Clin Oral Implant Res. 2014. doi: 10.1111/clr.12381
16. Calvo-Guirado JL, Gómez-Moreno G, Maté-Sánchez JE, López-Marí L, Delgado-Ruiz R, Romanos GE. New bone formation in bone defects after melatonin and porcine bone grafts: experimental study in rabbits. Clin Oral Implant Res. 2014. doi: 10.1111/clr.12364
17. Calvo-Guirado JL, Gómez-Moreno G, Delgado-Ruiz RA, MatéSánchez de Val JE, Negri B, RamírezFernández MP. Clinical and radiographic evaluation of osseotite-expanded platform implants related to crestal bone loss: a 10-year study. Clin Oral Implant Res. 2014; 25(3): 352-358. doi: 10.1111/clr.12134.
18. Calvo-Guirado JL, Boquete-Castro A, Negri B, Delgado Ruiz R, Gómez-Moreno G, Iezzi G. Crestal bone reactions to immediate implants placed at different levels in relation to crestal bone. A pilot study in Foxhound dogs. Clin Oral Implant Res. 2014; 25(3): 344-351. doi: 10.1111/clr.12110.
19. Calvo-Guirado JL, Delgado-Peña J, Maté-Sánchez JE, MarequeBueno J, Delgado-Ruiz RA, Romanos GE. Novel hybrid drilling protocol: evaluation for the implant healing - thermal changes, crestal bone loss, and bone-to-implant contact. Clin Oral Implant Res. 2014. doi: 10.1111/clr.12341
20. . Negri B, CalvoGuirado JL, MatéSánchez de Val JE, Delgado Ruíz RA, RamírezFernández MP, Barona Dorado C. Peri-implant tissue reactions to immediate nonocclusal loaded implants with different collar design: an experimental study in dogs. Clin Oral Implant Res. 2014; 25(2): e54-63. doi: 10.1111/clr.12047.
21. Calvo-Guirado JL, Gómez-Moreno G, Aguilar-Salvatierra A, Guardia J, Delgado-Ruiz RA, Romanos GE. Marginal bone loss evaluation around immediate non-occlusalmicrothreaded implants placed in fresh extraction sockets in the maxilla: a 3-year study. Clin Oral Implant Res. 2014. doi: 10.1111/clr.12336
22. Negri B, Calvo-Guirado JL, MatéSánchez de Val JE, Delgado Ruiz RA, et al. Biomechanical and bone histomorphological evaluation of two surfaces on tapered and cylindrical root form implants: an experimental study in dogs. Clin Implant Dent Relat Res. 2013; 15(6): 799-808. doi: 10.1111/j.1708-8208.2011.00431.x
23. Calvo-Guirado JL, Aguilar-Salvatierra A, Delgado-Ruiz RA, et al. Histological and Histomorphometric Evaluation of Zirconia Dental Implants Modified by Femtosecond Laser versus Titanium Implants: An Experimental Study in Fox Hound Dogs. Clin Implant Dent Relat Res. 2013. doi: 10.1111/cid.12162
24. Delgado-Ruiz RA, Calvo-Guirado JL, Abboud M, et al. Connective Tissue Characteristics around Healing Abutments of Different Geometries: New Methodological Technique under Circularly Polarized Light. Clin Implant Dent Relat Res. 2013. doi: 10.1111/cid.12161
25. Calvo-Guirado JL, López-López PJ, Mate Sanchez JE, GargalloAlbiol J, Velasco Ortega E, Delgado Ruiz R. Crestal bone loss related to immediate implants in crestal and subcrestal position: a pilot study in dogs. Clin Oral Implant Res. 2013. doi: 10.1111/clr.12267.
26. Calvo-Guirado JL, Ramírez-Fernández MP, Delgado-Ruíz RA, Maté-Sánchez JE, Velasquez P, de Aza PN. Influence of Biphasic β-TCP with and without the use of collagen membranes on bone healing of surgically critical size defects. A radiological, histological, and histomorphometric study. Clin Oral Implant Res. 2013. doi: 10.1111/clr.12258
27. Velasquez P, Luklinska ZB, Meseguer-Olmo L, Mate-Sanchez de Val JE, et al. alpha TCP ceramic doped with dicalcium silicate for bone regeneration applications prepared by powder metallurgy method: in vitro and in vivo studies. J Biomed Mater Res A. 2013; 101(7): 1943-1954. doi: 10.1002/jbm.a.34495.
28. Marković A, Calvo-Guirado JL, Lazić Z, et al. Evaluation of primary stability of self-tapping and non-self-tapping dental implants. A 12-week clinical study. Clin Implant Dent Relat Res. 2013; 15(3): 341-349. doi: 10.1111/j.1708-8208.2011.00415.x.
29. Ramírez-Fernández MP, Calvo-Guirado JL, Delgado-Ruiz RA, Maté-Sánchez del Val JE, Negri B, Diago MP. Ultrastructural study by backscattered electron imaging and elemental microanalysis of biomaterial-to-bone interface and mineral degradation of bovine xenografts in maxillary sinus floor elevation. Clin Oral Implant Res. 2013; 24(6): 645-651. doi: 10.1111/j.1600-0501.2012.02439.x.
30. Ramírez-Fernández MP, Calvo-Guirado JL, Maté-Sánchez Del Val JE, Delgado-Ruiz RA, Negri B, Barona-Dorado C. Ultrastructural study by backscattered electron imaging and elemental microanalysis of bone-to-biomaterial interface and mineral degradation of porcine xenografts used in maxillary sinus floor elevation. Clin Oral Implant Res. 2013; 24(5): 523-530. doi: 10.1111/j.1600-0501.2011.02414.x.
31. Delgado-Ruiz RA, Calvo-Guirado JL, Abboud M, et al. Histologic and Histomorphometric Behavior of MicrogroovedZirconia Dental Implants with Immediate Loading. Clin Implant Dent Relat Res. 2013. doi: 10.1111/cid.12069
32. CalvoGuirado JL, RamírezFernández MP, Negri B, Delgado Ruiz RA, MatéSánchez de-Val JE, Gómez-Moreno G. Experimental model of bone response to collagenizedxenografts of porcine origin (OsteoBiol mp3): a radiological and histomorphometric study. . Clin Implant Dent Relat Res. 2013; 15(1): 143-151. doi: 10.1111/j.1708-8208.2011.00337.x.
33. Gómez-Moreno G, Aguilar-Salvatierra A, Guardia J, et al. The efficacy of a topical sialogogue spray containing 1% malic acid in patients with antidepressant-induced dry mouth: a double-blind, randomized clinical trial. Depress Anxiety. 2013; 30(2): 137-142. doi: 10.1002/da.22017
34. Ramírez-Fernández MP, Calvo-Guirado JL, de-Val JE. Melatonin promotes angiogenesis during repair of bone defects: a radiological and histomorphometric study in rabbit tibiae. Clin Oral Investig. 2013; 17(1): 147-158. doi: 10.1007/s00784-012-0684-6
35. Borgonovo AE, Censi R, Vavassori V, et al. Evaluation of the success criteria for zirconia dental implants: a four-year clinical and radiological study. Int J Dent. 2013. doi: 10.1155/2013/463073
36. Maté-Sánchez de Val JE, Calvo-Guirado JL, Delgado-Ruiz RA, et al. Physical properties, mechanical behavior, and electron microscopy study of a new α-TCP block graft with silicon in an animal model. J Biomed Mater Res A. 2012; 100(12): 3446-3454. doi: 10.1002/jbm.a.34259
37. Calvo-Guirado JL, Delgado-Ruíz RA, Ramírez-Fernández MP, Maté-Sánchez JE, Ortiz-Ruiz A, Marcus A. Histomorphometric and mineral degradation study of Ossceram: a novel biphasic B-tricalcium phosphate, in critical size defects in rabbits. Clin Oral Implant Res. 2012; 23(6): 667-675. doi: 10.1111/j.1600-0501.2011.02193.x.
38. Negri B, Calvo-Guirado JL, Pardo-Zamora G, Ramírez-Fernández MP, Delgado-Ruíz RA, Muñoz-GuzónF. Peri-implant bone reactions to immediate implants placed at different levels in relation to crestal bone. Part I: a pilot study in dogs. Clin Oral Implant Res. 2012; 23(2): 228-235. doi: 10.1111/j.1600-0501.2011.02290.x.
39. Calvo-Guirado JL, Aguilar-Salvatierra A, Guardia J, et al. Evaluation of periimplant bone neoformation using different scanning electron microscope methods for measuring BIC. A dog study. Clin Exp Dent. 2012; 4(1): e8-e13. doi: 10.4317/jced.50624
40. Scepanovic M, Calvo-Guirado JL, Markovic A, et al. A 1-year prospective cohort study on mandibularoverdentures retained by mini dental implants. Eur J Oral Implantol. 2012; 5(4): 367-379.
41. Ramírez-Fernández M, Calvo-Guirado JL, Delgado-Ruiz RA, Maté-Sánchez del Val JE, Vicente-Ortega V, Meseguer-Olmos L. Bone response to hydroxyapatites with open porosity of animal origin (porcine [OsteoBiol mp3] and bovine (Endobon)): a radiological and histomorphometric study. Clin Oral Implant Res. 2011; 22(7): 767-773. doi: 10.1111/j.1600-0501.2010.02058.x
42. Ramírez-Fernández MP, Calvo-Guirado JL, Delgado-Ruiz RA, Maté-Sánchez del Val JE, Gómez-Moreno G, Guardia J. Experimental model of bone response to xenografts of bovine origin (Endobon): a radiological and histomorphometricstudy. Clin Oral Implant Res. 2011; 22(7): 727-734. doi: 10.1111/j.1600-0501.2010.02052.x.
43. Calvo-Guirado JL, Mate-Sanchez J, Delgado-Ruiz R, Ramirez-Fernández MP, Cutando-Soriano A, Pena M. Effects of growth hormone on initial bone formation around dental implants: a dog study. Clin Oral Implant Res. 2011; 22(6): 587-593. doi: 10.1111/j.1600-0501.2010.02007.x
44. Calvo-Guirado JL, Maté-Sánchez JE, Delgado-Ruiz R, Ramírez-Fernández MP. Med Oral Patol Oral Cir Bucal. Calculation of bone graft volume using 3D reconstruction system. Med Oral Patol Oral Cir Bucal. 2011; 16(2): e260-e264.
45. Delgado-Ruíz RA, Calvo-Guirado JL, Moreno P, et al. Femtosecond laser microstructuring of zirconia dental implants. J Biomed Mater Res B Appl Biomater. 2011; 96(1): 91-100. doi: 10.1002/jbm.b.31743.
46. Calvo-Guirado JL, Ramírez-Fernández MP, Gómez-Moreno G, et al. Melatonin stimulates the growth of new bone around implants in the tibia of rabbits. J Pineal Res. 2010; 49(4): 356-363. doi: 10.1111/j.1600-079X.2010.00801.x
47. Calvo-Guirado JL, Ortiz-Ruiz AJ, López-Marí L, et al. Immediate maxillary restoration of single-tooth implants using platform switching for crestal bone preservation: a 12-month study. Int J Oral Maxillofac Implants. 2009; 24(2): 275-281.

Zhong Zheng, PhD

Assistant Professor, Adjunct Series
Dental and Craniofacial Research Institute and Section of Orthodontics
School of Dentistry
University of California 675 Charles E. Young Drive, South
Room 2641, MacDonald Medical Research Laboratory
CA 90095,Los Angeles, USA

BiographyResearch InterestScientific ActivitiesPublications

Dr. Zheng received his PhD from Department of Biological Sciences and Biotechnology at Tsinghua University in Beijing, China.Additionally, he received postdoctoral training from the Department of Surgery at USC, the Department of Orthopaedic Surgeryat UCLA,and the School of Dentistryat UCLA.He currently is an Adjunct Assistant Professor at the UCLA School of Dentistry and has been extensively engaged in research on developing functional biomaterials with applications for tissue engineering. He has been committed to using fibromodulin (FMOD) to manage skin wound healing processes and to using silver nanoparticle-based materials to improve orthopaedic and orthodonticsurgeries. Currently Dr. Zheng is focused on developing cell-based regenerative medicines for musculoskeletal tissue engineering.

His research interests includes: Biomaterials, Microbiology, Nano-materials, Nanotechnologies, Regeneration Medicine, Stem Cell, Tissue Engineering

HONORS AND AWARDS

• 2007 International Health Professional of the year University of Southern California
• 2004 DuPond Scholorship Tsinghua University, Beijing, P. R. China
• 2003 Guang-Hua Scholar Tsinghua University, Beijing, P. R. China
• 1996 1st Prize in Chinese National Biology Olympiad Xinhua High School, Tianjin, P. R. China
• 1996 2nd Prize in Tianjin Chemistry Olympics Contest Xinhua High School, Tianjin, P. R. China

1. Zheng Z, Lee K, Zhang X, et al. Fibromodulin-deficiency alters temporospatial expression patterns of transforming growth factor beta ligands and receptors during adult mouse skin wound healing. PLOS ONE. 2014;93: e90817. PMCID: PMC3948369. doi: 10.1371/journal.pone.0090817.
2. Jia Jian, Zheng Z, Zhang K, et al. Fibromodulin promoted in vitro and in vivo angiogenesis. Biochemical and Biophysical Research Communications. 2013; 436: 537-542. doi: 10.1016/j.bbrc.2013.06.005
3. Yi Liu, Zheng Z, Zara J, et al. The antimicrobial and osteoinductive properties of silver nanoparticle/polyDL-lactic-co-glycolic acid-coated stainless steel. Biomaterials. 2012; 33: 8745-8756. doi: 10.1016/j.biomaterials.2012.08.010
4. Zheng Z, Jian J, Zhang X, et al. Reprogramming of human fibroblasts into multipotent cells with a single extracellular matrix proteoglycan, fibromodulin. Biomaterials . 2012; 33: 5821-5831. 13. doi: 10.1016/j.biomaterials.2012.04.049.
5. XuanZou, Shen J, Chen F, et al. Nell-1 binds to APR3 affecting human osteoblast proliferation and differentiation. FEBS Letters. 2011;585: 2410-2418.PMCID: PMC3209538. 12 doi: 10.1016/j.febslet.2011.06.024.
6. Zhang X, Peault B, Chen W, et al. The Nell-1 growth factor stimulates bone formation by purified human perivascular cells. Tissue Engineering, Part A. 2011; 17: 2497-2509. doi: 10.1089/ten.TEA.2010.0705.
7. Zheng Z, Nguyen C, Zhang X, et al. Delayed wound closure in fibromodulin deficient mice is associated with increased TGF-alpha3 signaling. Journal of Investigative Dermatology . 2011; 131: 769-778.PMCID: PMC4073663. 19. doi: 10.1038/jid.2010.381.
8. Khorasani H, Zheng Z, Nguyen C, et al. A Quantitative Approach to Scar Analysis. American Journal of Pathology. 2011; 178: 621-628. doi: 10.1016/j.ajpath.2010.10.019
9. Zheng Z, Yinco W, Zara J, et al. The use of BMP-2 coupled-nanosilver-PLGA composite grafts to induce bone repair in grossly infected segmental defects. Biomaterials. 2010; 31 35: 9293-9300. doi: 10.1016/j.biomaterials.2010.08.041
10. Zheng Z, Ming L, Xue X, et al. Mutation on N-terminus of polyhydroxybutyrate synthase of Ralstoniaeutropha enhanced PHB accumulation. Applied Microbiology and Biotechnology . 2006; 725: 896-905. doi: 10.1007/s00253-006-0371-0
11. Zhong Leo Zheng, Li Z, et al. Molecular cloning and functional analysis of R 3 hydroxyacyl acyl carrier protein coenzyme A transacylase from Pseudomonas mendocina LZ. FEMS Microbiology Letters. 2005; 2522: 299-307. 4. doi: 10.1016/j.femsle.2005.09.006
12. Tao Liu, Chen J, Zheng Z, Wang T, Chen G. Construction of highly efficient E. coli expression systems containing low oxygen induced promoter and partition region. Applied Microbiology and Biotechnology. 2005; 63: 346-354. doi: 10.1007/s00253-005-1913-6
13. Zheng Z, Bei F, Tian V, Chen G. Effect of crystallization of polyhydroxyalkanoate blend on surface physicochemical properties and interactions with rabbit articular cartilage chondrocytes. Biomaterials. 2005; 26 17: 3537-3548. doi: 10.1016/j.biomaterials.2004.09.041
14. Tian S, Lai W, Zheng Z, Wang H, Chen G. Effect of over-expression of phasin gene from Aeromonashydrophila on biosynthesis of copolyesteres of 3-hydroxybutyrate and 3-hydroxyhexanoate. FEMS Microbiology Letters .2005; 2441: 19-25.
15. Chen G, Wu Q, Wang Y, Zheng Z. Application of microbial polyesters-polyhydroxyalkanoates as tissue engineering materials. Advanced Biomaterials VI: Key Engineering Materials . 2005; 288-289: 437-440. doi: 10.4028/www.scientific.net/KEM.288-289.437
16. Zheng Z, Chen J, Tian H, Bei F, Chen G. Specific identification of R-3-hydroxyacylACP:CoAtransacylase gene from Pseudomonas and Burkholderia strains by polymerase chain reaction. Sheng Wu Gong Cheng XueBao. 2005; 211: 19-24.
17. Zheng Z, Gong Q, Chen J. Novel method for production of 3-hydroxydecanoic acid by recombinant Escherichia coli and Pseudomonas putida. Chinese Journal of Chemical Engineering. 2004; 124: 550-555.
18. Zheng Z, Gong Q, Liu T, Deng Y, Chen G. Thioesterase II of Escherichia coli plays an important role in 3-hydroxydecanoic acid production. Applied and Environmental Microbiology . 2004; 707: 3807-3813. doi: 10.1128/AEM.70.7.3807-3813.2004
19. Chen J, Liu T, Zheng Z, Chen J, Chen G. Polyhydroxyalkanoate synthases PhaC1 and PhaC2 from Pseudomonas stutzeri 1317 had different substrate specificities. FEMS Microbiology Letters. 2004; 2342: 231-237.
20. Zheng Z, Zhang M, Zhang G, Chen G. Production of 3-hydroxydecanoic acid by recombinant Escherichia coli HB101 harboring phaG gene. Antonie van Leeuwenhoek International Journal of General and Molecular Microbiology. 2004; 852: 93-101.
21. Wu Q, Zheng Z, Xi J, Gao H, Chen G. Production of hydroxyalkanoate monomers by microbial fermentation. Journal of Chemical Engineering of Japan. 2003; 3610: 1170-1173.
22. Deng Y, Lin Y, Zheng Z, et al. Polyhydroxybutyrate co hydroxyhexanoate promoted production of extracellular matrix of articular cartilage chondrocytes in vitro. Biomaterials .2003; 24(23): 4273-4281. doi: 10.1016/S0142-9612(03)00367-3
23. Zheng Z, Deng Y, Lin X, Zhang L, Chen G. Induced production of rabbit articular cartilage-derived chondrocyte collagen II on polyhydroxyalkanoate blends. Journal of Biomaterials Science-Polymer Edition. 2003; 147: 615-624.
24. Zhao K, Tian G, Zheng Z, Chen J, Chen G. Production of D-3-hydroxyalkanoic acid by recombinant Escherichia coli. FEMS Microbiology Letters. 2003; 2181: 59-64.

Junichi Iwata, PhD, DDS

Assistant Professor
Departments of Diagnostic and Biomedical Sciences
School of Dentistry
The University of Texas Health Science Center
1941 East Road, BBS 4208, Houston, TX 77054, USA

BiographyResearch InterestScientific ActivitiesPublications

Dr. Iwata graduated from School of Dentistry, Kyushu University (Japan) in 2000 and received his PhD at the Graduate School of Dentistry, Kyushu University in 2004. He worked as an Assistant Professor at the Medical School, Juntendo University (Japan) through 2004 to 2007. He then worked at the School of Dentistry, University of Southern California from 2007 to 2013. Dr. Iwata is currently working at the School of Dentistry, University of Texas at Houston as an Assistant Professor. He has been involved in developmental biology research. His group focuses on understanding molecular mechanisms that cause craniofacial and brain developmental defects.

Dr. Iwata’s research focuses on understanding molecular mechanisms that cause craniofacial birth defects. His group is working on regulatory mechanisms of 1) exocytosis mediated by autophagy, 2) microRNAs, 3) cellular cholesterol metabolism, 4) WNT signaling, etc. More recently, his group has expanded their research into the area of stem cells and brain development. His group has generated new genetic mouse models and has been characterizing the molecular mechanism using multidisciplinary approaches including genetics, genomics, proteomics, and bioinformatics. His study tries to identify the novel mechanisms that control development and allows develop new therapeutic methods for birth defects and regeneration.

OTHER EXPERIENCE AND PROFESSIONAL MEMBERSHIPS

• 2007-Present Member, International Association for Dental Research
• 2007-Present Member, American Association for Dental Research
• 2013-Present Member, American Dental Education Association
• 2013-Present Editorial Board, Academic Editor, Progressive Science
• 2014-Present Editorial Board, Journal of Dentistry and Clinical Research
• 2014-Present Lead Guest Editor, BioMed Research International
• 2014-Present Editorial Board, Journal of Bioinformatics, Computational and Systems Biology


HONORS AND AWARDS

• 2000-2003 Scholarship, the Japan Scholarship Foundation
• 2003-2004 Research Fellow Award of the Japan Society for the Promotion Science
• 2009 Poster Presentation Award, USC Research Day 2009
• 2011 Travel Award for the FaceBase Annual Meeting, Denver, Colorado
• 2011 Poster Presentation Award, USC Research Day 2011
• 2011 Symposium Organizer, The 88th Annual Meeting of the Physiological Society of Japan, The 116th Annual Meeting of the Japanese Association of Anatomists
• 2012 Travel Award for the FaceBase Annual Meeting, Los Angeles, California
• 2012 Innovative Scientific Award from USC School of Dentistry
• 2013 Travel Award for the FaceBase Annual Meeting, Iowa City, Iowa
• 2013 Dean’s Research Award from USC School of Dentistry
• 2013 Poster Presentation Award, USC Research Day 2013
• 2013 “Papers of the Week” Award from J Biol Chem
• 2013 Cover image chosen for J Biol Chem. 288
• 2014 Award of “Best of the Year 2013” articles of J Biol Chem

PEER-REVIEWED PAPERS

1. Iwata J, Suzuki A, Yokota T, et al. TGFβ regulates epithelial-mesenchymal interactions via WNT signaling activity to control muscle development in the soft palate. Development. 2014; 141(4): 909-917. doi: 10.1242/dev.103093
2. Iwata J, Suzuki A, Pelikan RC, Ho TV, Sanchez-Lara PA, Chai Y. Modulation of lipid metabolic defects rescues cleft palate in Tgfbr2 mutant mice. Hum Mol Genetics. 2014; 23(1): 182-193. doi: 10.1093/hmg/ddt41
3. Iwata J, Suzuki A, Pelikan RC, Ho TV, Chai Y. Cranial neural crest cells regulate tongue muscle formation via TGFβ–mediated BMP and FGF signaling. J Biol Chem. 2013; 288: 29760-29770. doi:
4. Parada C, Li J, Iwata J, Suzuki A, Chai Y. CTGF mediates Smad-dependent transforming growth factor b signaling to regulate mesenchymal cell proliferation during palate development. Mol Cell Biol. 2013; 33(17): 3482-3493. doi: 10.1128/MCB.00615-13
5. Koike M, Tanida I, Nanao T, et al. Enrichment of GABARAP relative to LC3 in the axonal initial segments of neurons. PLoS One. 2013; 8(5): e63568. doi: 10.1371/journal.pone.0063568
6. Song ZC, Liu C, Iwata J, et al. Mice with Tak1-deficiency in neural crest lineage exhibit cleft palate associated with abnormal tongue development. J Biol Chem. 2013; 288(15): 10440-10450. doi: 10.1074/jbc.M112.432286
7. Iwata J, Suzuki A, Pelikan RC, et al. Smad4–Irf6 genetic interaction and TGFβ–mediated IRF6 signaling cascade are crucial for palatal fusion in mice. Development. 2013; 140(6): 1220-1230. doi: 10.1242/dev.089615.
8. Pelikan RC, Iwata J, Suzuki A, Chai Y, Hacia JG. Identification of candidate downstream targets of TGFβ signaling during palate development by genome-wide transcript profiling. J Cell Biochem. 2013; 114: 796-807. doi: 10.1002/jcb.24417
9. Iwata J, Hacia JG, Suzuki A, Sanchez-Lara PA, Urata M, Chai Y. Modulation of non-canonical TGF-β signaling prevents cleft palate in Tgfbr2 mutant mice. J Clin Invest. 2012; 122(3): 873-885. doi: 10.1172/JCI61498
10. Iwata J, Tung L, Urata M, et al. Fibroblast growth factor 9(FGF9)–pituitary homeobox 2(PITX2) pathway mediates transforming growth factor beta(TGFβ) signaling to regulate cell proliferation in palatal mesenchyme during mouse palatogenesis. J Biol Chem. 2012; 287(4): 2353-1363. doi: 10.1074/jbc.M111.280974
11. Okamoto K, Okamoto Y, Kawakubo T, et al. Role of the transcription factor Sp1 in regulating the expression of the murine cathepsin E gene. J Biochem. 2011; 151(3): 263-272. doi: 10.1093/jb/mvr135
12. Huang XF, Yokota T, Iwata J, Chai Y. TGF-β mediated FasL-Fas-caspase pathway is crucial during palatogenesis. J Dent Res. 2011; 90(8): 981-987. doi: 10.1177/0022034511408613
13. Ezaki J, Matsumoto N, Takeda-Ezaki M, et al. Liver autophagy contributes to the maintenance of blood glucose and amino acid levels. Autophagy. 2011; 7(7): 727-736. doi: 10.4161/auto.7.7.15371
14. Hochheiser H, Aronow BJ, Artinger K, et al. The FaceBase Consortium: A comprehensive program to facilitate craniofacial research. Dev Biol. 2011; 355(2): 175-182. doi:
15. Iwata J, Hosokawa R, Sanchez-Lara PA, Urata M, Slavkin H, Chai Y. Transforming growth factor-beta regulates basal transcriptional regulatory machinery to control cell proliferation and differentiation in cranial neural crest–derived osteoprogenitor cells. J Biol Chem. 2010; 285(7): 4975-4982. doi: 10.1074/jbc.M109.035105
16. Chung IH, Han J, Iwata J, Chai Y. Msx1 and Dlx5 function synergistically to regulate frontal bone development. Genesis. 2010; 48(11): 645-655. doi: 10.1002/dvg.20671
17. Hosokawa R, Oka K, Yamaza T, et al. TGF-β mediated FGF10 signaling in cranial neural crest cells controls development of myogenic progenitor cells through tissue-tissue interactions during tongue morphogenesis. Dev Biol. 2010; 341(1): 186-195. doi: 10.1016/j.ydbio.2010.02.030
18. Sou Y, Waguri S, Iwata J, et al. The Atg8 conjugation system is indispensable for proper development of autophagic isolation membranes in mice. Mol Biol Cell. 2008; 19(11): 4762-4775. doi: 10.1091/mbc.E08-03-0309.
19. Komatsu M, Waguri S, Koike M, et al. Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice. Cell. 2007; 131, 1149-1163. doi: http://dx.doi.org/10.1016/j.cell.2007.10.035
20. Kawakubo T, Okamoto K, Iwata J, et al. Cathepsin E prevents tumor growth and metastasis by catalyzing the proteolytic release of soluble TRAIL from tumor cell surface. Cancer Research. 2007; 67(22): 10869-10878. doi: 10.1158/0008-5472.CAN-07-2048
21. Shin M, Kadowaki T, Iwata J, et al. Association of cathepsin E with tumor growth arrest through angiogenesis inhibition and enhanced immune responses. Biol Chem. 2007; 388(11): 1173-1181. doi: 10.1515/BC.2007.154,
22. Komatsu M, Wang QJ, Holstein GR, et al. Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration. Proc Natl Acad Sci USA. 2007; 104(36): 14489-14494. doi: 10.1073/pnas.0701311104
23. Komatsu M, Waguri S, Chiba T, et al. Loss of autophagy in the central nervous system causes neurodegeneration. Nature. 2006; 441(7095): 880-884. doi: 10.1038/nature04723
24. Iwata J, Ezaki J, Komatsu M, et al. Excess peroxisomes are degraded by autophagic machinery in mammals. J Biol Chem. 2006; 281: 4035-4041. doi: 10.1074/jbc.M512283200
25. Komatsu M, Waguri S, Ueno T, et al. Impairment of starvation–induced and constitutive autophagy in Atg7–deficient mice. J Cell Biol. 2005; 169: 425-434. doi: 10.1083/jcb.200412022

Lakshman Samaranayake, DSc(Hon), DDS(Glas), FRCPath(UK), FDSRCSE(Hon), FHKCPath, FCDSHK

Professor of Oral Microbiomics and Infection
Dean Emeritus (Dentistry), University of Hong Kong
Head of School, School of Dentistry
The University of Queensland
200 Turbot St, Brisbane 4000
Australia

BiographyResearch InterestScientific ActivitiesPublications

Professor Sam Samaranayake is the Head, and the Professor of Oral Microbiomics and Infection at the University of Queensland, School of Dentistry. Prior to this he served as the Dean of the Faculty of Dentistry at the University of Hong Kong for a decade. He is also an Honorary Professor at the Eastman Dental Institute, London and many international universities including China, Saudi Arabia, India and Indonesia.
Professor Samaranayake earned his doctoral degree at the University of Glasgow, UK where he was a Consultant/ Senior Lecturer in Oral Medicine and Pathology. Then he served as an Associate Professor at the University of Alberta, Canada, and subsequently at the University of Hong Kong.
Prof Samaranayake, considered the foremost international authority in oral candidal infections and, has authored more than 400 publications cited in the literature over 12,000 times. For his research he has received a number of awards and honors including the Distinguished Scientist Award of the International Association for Dental Research, Washington, USA, and themuch covetedKing James IV Professorship ofthe Royal College of Surgeons of Edinburgh UK.
He has served as a World Bank Consultant in Problem Based Learning (PBL), a council member of the FDI and the Chair of its Science Commission. He is a much sought after speaker and lectured extensively in more than 40 countries, on the subjects of oral micriobiomics, infection control and dental education.

His research interests include Infections in medically compromised individuals, mainly oral candidiasis (more than 180 refereed papers), clinical oral microbiology, and infection control in dental practice.

HONORS AND AWARDS


UNIVERSITY OF HONG KONG


• Tam Wah-Ching Endowed Professor in Dental Science (2010 )
• Outstanding Researcher Award, The University of Hong Kong, Hong Kong, 2001
• Outstanding Research Student Supervisor Award, The University of Hong Kong, Hong Kong, 2001
• Research Output Prize, Faculty of Dentistry, 2009
• Research Output Prize, Faculty of Dentistry, 2010 (as a co-investigator)
• Primary Supervisor of Outstanding Research Postgraduate Student (Dr. C.J. Seneviratne), Faculty of Dentistry, 2009


OTHER UNIVERSITIES AND PROFESSIONAL BODIES


• Honorary Fellowship of the Royal Australasian College of Dental Surgeons, 2013-2014
• Distinguished Service Award by the International Association for Dental Research (SEA Division), 2013
• King James IV Professorship (2011) of the Royal College of Surgeons of Edinburgh, UK (The only Asian to have received this high honor either in Medicine or Dentistry)
• Distinguished Scientist Award (Oral Medicine and Pathology), International Association for Dental Research, 2010 (The only Asian to have received this honour)
• Doctor of Science: DSc (honoris causa), University of Peradeniya, Sri Lanka, 2005 (The first of two dental professionals in Sri Lanka to receive this high honour, from the oldest University in the country)
• Fellowship in Dental Surgery Royal College of Surgeons (FDSRCS) (ad hominem), UK, 2005
• Fellow of Oman Dental College. Oman (2012)
• Honorary Professor, Eastman Dental Institute, University College, London, UK (2004-2008)
• Honorary Professor, King Saud University School of Dntistry, Saudi Arabia (2013)
• Advisory Professor, Shanghai Jiao Tong University, School of Medicine, China (2007- )
• Visiting Professor, Guanghua College of Stomatology, Sun Yat-sen University, Guangzhou, China (2005)
• Adjunct Professor , Faculty of Dentistry, Univeritas Indonesia, Jakarta, Indonesia (2009- )
• Visiting Professor, Faculty of Dentistry, Thamasat University, Thailand (1999-2004)
• Honorary Member, American Dental Association, USA (2007)
• Honorary Member, Macau Dental Association, Macau, China (2003)
• Vice-Presidential nominee: International Association for Dental Research (IADR) – (2004, 2009)
• Expert Consultant and Key Opinion Leader for Asia Pacific, Colgate Company, USA – (2008, 2009)


PREVIOUS HONORARY APPOINTMENTS AND KEY POSITIONS


• Council member, International Dental Federation (FDI) (2003-2006)
• Chairman, Science Commission of the International Dental Federation (FDI) (2003-2007)
• External Examiner in basic biological sciences, Royal College of Surgeons, Edinburgh, UK (Hong Kong Diet 1999-2001)
• Chairman, Hatton Awards Committee, International Association for Dental Research, USA (2002-2004)
• World Bank Technical Consultant for the QUE (Quality Undergraduate Education) Project of the Faculty of Dentistry, University of Indonesia (2002-2004)
• Honorary Consultant to the Hong Kong Government `Quality Education Fund` for problem based learning in secondary schools (2002-2004)
• Ad-hoc consultant to the Danish Development Agency, AIDS Programme, Rural Health Project of Thailand, Hat Yai, Thailand (1994)
• Ad-hoc Consultant to the World Health Organisation (1993) and the Medical Research Council of Canada (1994) to review manuscripts and research proposals, respectively
• External Assessor to the following Promotion and Tenure Committees: Faculty of Dentistry, Ohio State University, USA (1992), University of Wales, UK (2000), University of Sydney (2002), University of Peradeniya, Sri Lanka (2006, 2008), University of Otago, New Zealand (2008), University of California, Los Angeles (2008)
• Ad-hoc Consultant in microbiology, Procter & Gamble Company, Ohio, USA (1992), Pharmacia Corporation, USA (2002-2004), Colgate Palmolive (many occasions), Johnson and Johnson (many occasions)
• Senior Medical Research Fellow, University of the Western Cape, South Africa (1989)
• Alberta Heritage Trust Visiting Fellow, University of Alberta, Edmonton, Canada (1988)

PEER REVIEWED ORIGINAL RESEARCH ARTICLES

1. Wikramanayake TW, Samaranayake LP and Dissanayake S. Human cord blood and colostrum immunoglobulin levels. Ceylon Medical Journal. 1976; 21: 244-248.
2. Wikramanayake TW, Samaranayake LP and Dissanayake S. Socio economic status and the foeto placental unit. Ceylon Medical Journal. 1976; 22: 10-108.
3. Samaranayake LP, MacFarlane TW. An in vitro study of the adherence of Candida albicans to acrylic surfaces. Archives of Oral Biology. 1980; 25: 603-610. doi:10.1016/0003-9969(80)90075-8
4. Samaranayake LP, McCourtie J, MacFarlane TW. Factors affecting the adhesion of Candida albicans to acrylic surfaces. Archives of Oral Biology. 1980; 25: 611-615.
5. Samaranayake LP and MacFarlaneTW. The adhesion of the yeast Candida albicans to epithelial cells of human origin in vitro. Archives of Oral Biology. 1981; 26: 815-820.
6. Samaranayake LP, MacFarlane TW. A retrospective study of patients with recurrent chronic atrophic candidosis. Oral Surgery, Oral Medicine, Oral Pathology. 1981; 52: 150-153. doi: 10.1016/0030-4220(81)90312-1
7. Samaranayake LP, MacFarlane TW. Factors affecting the in vitro adhesion of the oral fungal pathogen Candida albicans to epithelial cells of human origin. Archives of Oral Biology. 1982; 27: 869-873. doi: 10.1016/0003-9969(82)90043-7
8. Samaranayake LP, MacFarlane TW. The effect of dietary carbohydrates on the in vitro adhesion of Candida albicans to human epithelial cells. Journal of Medical Microbiology. 1982; 15: 511-517. doi:10.1099/00222615-15-4-511
9. Samaranayake LP, Geddes DAM, Weetman DA, MacFarlane TW. Isotachophoretic analysis of short chain carboxylic acids produced by Candida albicans. Microbios. 1982; 35: 91-98.
10. Samaranayake LP, Geddes DAM, Weetman DA, MacFarlane TW. Carboxylic acids and pH of denture plaque in patients with denture stomatitis. Journal of Oral Pathology 1983; 12: 84-89. doi: 10.1111/j.1600-0714.1983.tb00321.x
11. Samaranayake LP, Geddes DAM, Weetman DA, MacFarlane TW. Growth and acid production of Candida albicans in carbohydrate sulemented media. Microbios 1983; 37: 105-115.
12. MacFarlane TW, McGill JC, Samaranayake LP. Angular cheilitis as a source of Staphylococcus aureus. Communicable Diseases Scotland. 1983; 17(37): 9-10.
13. Samaranayake LP, Hughes A, MacFarlane TW. The proteolytic potential of Candida albicans in human saliva sulemented with glucose. Journal of Medical Microbiology. 1984; 17: 13-22. doi: 10.1099/00222615-17-1-13
14. Samaranayake LP, Raeside J, MacFarlane TW. Factors affecting the phospholipase activity of Candida species in vitro. Sabouraudia. Journal of Medical and Veterinary Mycology. 1984; 22: 201-207. doi: doi: 10.1080/00362178485380331
15. Samaranayake LP, Calman C, Ferguson MM, MacFarlane TW and Main B. The oral carriage of yeasts and coliforms in patients on cytotoxic therapy. Journal of Oral Pathology. 1984; 13: 390-393. doi: 10.1111/j.1600-0714.1984.tb01438.x
16. Main B, Calman KC, Ferguson MM, et al. The effects of cytotoxic therapy on saliva and oral flora. Oral Surgery, Oral Medicine, Oral Pathology. 1984; 58: 545-548. doi: 10.1016/0030-4220(84)90077-X
17. MacFarlane TW, McGill JC, Samaranayake LP. Antibiotic sensitivity and phage typing of Staphylococcus aureus isolated from non hospitalised patients with angular cheilitis. Journal of Hospital Infection. 1984; 5: 444-446. doi: 10.1016/0195-6701(84)90015-X
18. Samaranayake LP, MacFarlane TW. Hypothesis: On the role of dietary carbohydrates in the pathogenesis of oral candidosis. FEMS Microbiology Letters. 1985; 527: 1-5.
19. Lamey PJ, MacFarlane TW, Patton DW, Samaranayake LP, Ferguson MM. Bacteraemia consequential to sialography. British Dental Journal. 1985; 158: 218-220. doi: 10.1038/sj.bdj.4805574
20. McCourtie J, MacFarlane TW, Samaranayake LP. Effect of chlorhexidine gluconate on the adherence of Candida species to acrylic surfaces. Journal of Medical Microbiology. 1985; 20: 97-104. doi: 10.1099/00222615-20-1-97
21. McCourtie J, MacFarlane TW, Samaranayake LP. Effect of saliva and serum on the adherence of Candida species to chlorhexidine treated denture acrylic. Journal of Medical Microbiology. 1986; 21: 209-213. doi: 10.1099/00222615-21-3-209
22. Williamson MI, Samaranayake LP, MacFarlane TW. Biotypes of oral Candida albicans and Candida tropicalis isolates. Journal of Medical and Veterinary Mycology. 1986; 24: 81-84. doi: doi:10.1080/02681218680000101
23. McCourtie J, MacFarlane TW,. Samaranayake LP. A comparison of the effects of chlorhexidine gluconate, amphotericin B and Nystatin on the adherence of Candida species to denture acrylic. Journal of Antimicrobial Chemotherapy. 1986; 17: 575-583. doi: 10.1093/jac/17.5.575
24. Samaranayake LP, Lamey PJ, Glass GWT, MacFarlane TW. Hepatitis B Vaccine and the Dental Practitioner. British Medical Journal. 1986; 292: 1050.
25. Samaranayake LP, Hughes A, Weetman DA, MacFarlane TW. Growth and acid production of Candida species in human saliva sulemented with glucose. Journal of Oral Pathology. 1986; 15: 251-254. doi: 10.1111/j.1600-0714.1986.tb00617.x
26. Williamson MI, Samaranayake LP, MacFarlane TW. Phospholipase activity as a criterion for biotyping Candida albicans. Journal of Medical and Veterinary Mycology. 1986; 24: 415- 417. doi: 10.1080/02681218680000631
27. Williamson MI, Samaranayake LP, MacFarlane TW. Biotypes of Candida albicans using the API 20C system. FEMS Microbiology Letters. 1986; 37: 27-29. doi: 10.1111/j.1574-6968.1986.tb01760.x
28. Samaranayake LP, MacFarlane TW, Lamey PJ, Ferguson MM. A comparison of oral rinse and imprint sampling techniques for the detection of yeast, coliform and Staphylococcus aureus carriage in the oral cavity. Journal of Oral Pathology 1986; 15: 386-388. doi: 10.1111/j.1600-0714.1986.tb00646.x
29. Lamey PJ, Boyle MA, MacFarlane TW, Samaranayake LP. Acute suurative parotitis in out patients: Microbiological and post treatment sialographic findings. Oral Surgery, Oral Medicine, Oral Pathology. 1987; 63: 37-41.
30. Samaranayake LP, MacFarlane TW, Williamson M. A Comparison of Sabouraud dextrose and Pagano Levin agar media for the detection and isolation of yeasts from clinical samples. Journal of Clinical Microbiology. 1987; 25: 162-164.
31. Samaranayake LP, Lamey PJ, MacFarlane TW, Glass GWJ. The attitudes of general dental practitioners towards the hepatitis B vaccine. Community Dentistry Oral Epidemiology. 1987; 15: 125-127.
32. Glass GWJ, Lamey PJ, Samaranayake LP. Communication between a specialist dental hospital department and referring general practitioners: An attempt at clinical audit. Community Dentistry Oral Epidemiology. 1987; 15: 277-278. doi: 10.1111/j.1600-0528.1987.tb00537.x
33. Tobgi RS, Samaranayake LP, MacFarlane TW. Adhesion of Candida albicans to buccal epithelial cells exposed to chlorhexidine gluconate. Journal of Medical and Veterinary Mycology. 1987; 25: 335-338.
34. Fisher BM, Lamey PJ, Samaranayake LP, MacFarlane TW and Frier BM. Carriage of Candida species in the oral cavity in diabetic patients: relationship to glycaemic control. Journal of Oral Pathology. 1987; 16: 282-284. doi: 10.1111/j.1600-0714.1987.tb01494.x
35. Williamson MI, Samaranayake LP, MacFarlane TW. A new simple method for biotyping Candida albicans. Microbios. 1987; 51: 159-167.
36. Sweet SP, MacFarlane TW , Samaranayake LP. Determination of cell surface hydrophobicity of oral bacteria using a modified hydrocarbon adherence method. FEMS Microbiology Letters. 1987; 48: 159-163. doi: 10.1111/j.1574-6968.1987.tb02534.x
37. McCartan BE, Samaranayake LP. Awareness and acceptance of hepatitis B vaccine by Irish Dental Practitioners. Irish Dental Journal. 1987; 33: 33-36.
38. Samaranayake LP, MacFarlane TW, Follett E. Prevalence and significance of Hepatitis B markers in a dental hospital: A retrospective study. Journal of Oral Medicine. 1987; 42: 205-207.
39. Samaranayake LP, Scully C, Dowell TB, et al. New data on the acceptance of hepatitis B vaccine by dental personnel in the United Kingdom. British Dental Journal. 1988; 164: 74-77. doi: 10.1038/sj.bdj.4806349
40. Lewis HL, Samaranayake LP, Lewis MAO, Lamey MK. Acceptance of hepatitis B vaccination by dental hygienists in the United Kingdom. Dental Health. 1988; 27: 7-11.
41. Tobgi RS, Samaranayake LP, MacFarlane TW. In vitro susceptibility of Candida species to Lysozyme. Oral Microbiology and Immunology. 1988; 3: 35-39. doi: 10.1111/j.1399-302X.1988.tb00603.x
42. Samaranayake LP, MacLaughlin L, MacFarlane TW. Adherence of Candida species to fibrin clots in vitro. Mycopathologia. 1988; 102: 135-138. doi: 10.1007/BF00437451
43. Sweet SP, MacFarlane TW, Samaranayake LP. An epifluorescence technique for studying the adherence of oral bacteria to buccal epithelial cells. Microbial Ecology in Health and Disease. 1988; 1: 221-226. doi:10.3402/mehd.v1i4.7419
44. Lamey PJ, Darawa AG, Fisher BM, Samaranayake LP, MacFarlane TW, Frier BM. Secretor status candidal carriage and oral candidal infection in patients with diabetes. Mellitus. Journal of Oral Pathology. 1988; 17: 354-357. doi: 10.1111/j.1600-0714.1988.tb01549.x
45. Samaranayake LP, Robertson AG, MacFarlane TW, et al. The effect of chlorhexidine and benzydamine mouthwashes on mucositis induced by therapeutic irradiation. Clinical Radiology. 1988; 39: 291-294. doi: 10.1016/S0009-9260(88)80538-5
46. Yaacob HB, Samaranayake LP. Awareness and acceptance of hepatitis B vaccine by dental practitioners in Malaysia. Journal of Oral Pathology and Medicine. 1989; 18: 236-239. doi: 10.1111/j.1600-0714.1989.tb00770.x
47. Sweet SP, MacFarlane TW, Samaranayake LP. An in vitro method to study the adherence of oral bacteria to HeLa cells. Microbios. 1989; 60: 15-22.
48. Samaranayake LP, Reid J and Evans D. The efficacy of rubber dam isolation in reducing atmospheric bacterial contamination ASDC. Journal of Dentistry for Children. 1989; 56: 442-444.
49. Samaranayake LP, Lamb AB, Lamey PJ, MacFarlane TW. Oral carriage of Candida species and coliforms in patients with burning mouth syndrome. Journal of Oral Pathology and Medicine. 1989; 18: 233-235.
50. Scully C, Pantlin L, Samaranayake LP, Dowell TB. Increasing acceptance of hepatitis B vaccine by dental personnel but reluctance to accept hepatitis B carrier patients. Oral Surgery, Oral Medicine, Oral Pathology. 1990; 69: 45-47. doi: http://dx.doi.org/10.1016/0030-4220(90)90267-V
51. Samaranayake LP, McDonald KC. Patient perception of cross infection prevention in dentistry. Oral Surgery, Oral Medicine, Oral Pathology. 1990; 69: 457-460. doi: 10.1016/0030-4220(90)90379-7
52. Sweet SP, MacFarlane TW, Samaranayake LP. An in vitro method to study the adherence of bacteria to saliva treated tooth enamel sections. Oral Microbiology and Immunology. 1990; 5: 24-28. doi: 10.1111/j.1399-302X.1990.tb00221.x
53. Samaranayake LP, Figueiredo HMJ, Rowland CA, Aitchison K. Comparison of the attitudes of hospital dentists and dental students in Glasgow and Los Angels, USA towards treatment of AIDS and hepatitis B patients. American Journal of Dentistry. 1990; 3: 9-14.
54. Flood T, Samaranayake LP, MacFarlane TW and MacKenzieDW. Bacteraemia following incision and drainage of dento alveolar abscesses. British Dental Journal. 1990; 69: 51-53.
55. McManners J , Samaranayake LP. Suurative oral candidosis: Review of the literature and report of a case. International Journal of Oral and Maxillofacial Surgery. 1990; 19: 257-259.
56. Darwazeh A, Lamey PJ, Samaranayake LP, et al. The relationship between colonisation, secretor status and in vitro adhesion of Candida albicans to buccal epithelial cells from diabetics. Journal of Medical Microbiology. 1990; 33: 43-49. doi:10.1099/00222615-33-1-43
57. Samaranayake LP, Hunjan M, and Jennings K. Carriage of oral flora on irreversible hydrocolloid and elastomeric impression materials. Journal of Prosthetic Dentistry. 1991; 65: 244-249.
58. Wilkieson,C, Samaranayake LP, MacFarlane TW, Lamey PJ, MacKenzie DW. Oral candidosis in the elderly in long term hospital care. Journal of Oral Pathology and Medicine. 1991; 20: 13-16. doi: 10.1111/j.1600-0714.1991.tb00880.x
59. Darwazeh AMG, Lamey PJ, Lewis MAO, Samaranayake LP. Systemic fluconazole therapy and in vitro adhesion of Candida albicans to human buccal epithelial cells. Journal of Oral Pathology and Medicine. 1991; 20: 17-19. doi: 10.1111/j.1600-0714.1991.tb00881.x
60. Lamey PJ, Darwazeh AMG, Muirhead J, Samaranayake LP, MacFarlane TW. Chronic hyperplastic candidosis and secretor status. Journal of Oral Pathology and Medicine. 1991; 20: 64-67. doi: 10.1111/j.1600-0714.1991.tb00891.x
61. Warnakulasuriya KAAS, Samaranayake LP, Peiris JSM. Angular cheilitis in a group of Sri Lankan adults: a clinical and microbiologic study. Journal of Oral Pathology and Medicine. 1991; 20: 172-175. doi: 10.1111/j.1600-0714.1991.tb00915.x
62. Jennings K, Samaranayake LP. The persistence of microorganisms on impression materials following disinfection. Journal of Prosthetic Dentistry. 1991; 4: 382-287.
63. McCartan BE, Samaranayake LP. Oral care of HIV infected patients: the knowledge and attitudes of Irish dentists. Journal of Irish Dental Association. 1991; 37: 41-43.
64. Hardie J, Samaranayake LP. A critique of HIV transmission during dental treatment. J. Can Dent Assoc. 1991; 57(6): 487-492.
65. Moola H, Samaranayake LP. Oral care of HIV infected patients: the knowledge and attitudes of Irish dentists. Journal of the Irish Dental Association 1992; 73: 304-306.
66. Darling M, Arendorf T, Samaranayake LP. Oral care of HIV-infected patients: the knowledge and attitude of South African dentists. Journal of the Dental Association of South Africa. 1992; 47: 399-402.
67. Samaranayake YH, MacFarlane TW, Samaranayake LP. The in vitro lysozyme susceptibility of Candida species cultured in sucrose sulemented media. Microbios. 1993; 74: 23-28.
68. Samaranayake YH, MacFarlane TW, Aitchison T, Samaranayake LP. The in vitro lysozyme susceptibility of Candida albicans cultured in carbohydrate sulemented media. Oral Microbiology and Immunology. 1993; 8: 177-181.
69. Nikawa H, Hayashi S, Nagata Y, Hamada M, Samaranayake LP. Interactions between denture lining material, protein pellicles and Candida albicans. Archives of Oral Biology. 1993; 38: 631-634. doi: http://dx.doi.org/10.1016/0003-9969(93)90132-6
70. Porter SR, Peake G, Scully C, Samaranayake LP. Attitudes to cross infection measures of UK and Hong Kong patients. British Dental Journal. 1993; 175: 254-257. doi: 10.1038/sj.bdj.4808292
71. Tsang P, Philipsen HP, Samaranayake LP. The attitudes and knowledge of a group of dental attenders in Hong Kong towards HIV infection. Hong Kong Practitioner. 1993; 15: 2904-2909.
72. Hashim BY, Samaranayake LP. The perception of acquired immunodeficiency syndrome among a group of patients and dentists. Hospital Dentistry (Tokyo). 1993; 5: 14-17.
73. Nikawa H, Samaranayake LP, Tenouvo J, Hamada T. The fungicidal effect of human lactoferrin on Candida albicans and Candida krusei. Archives of Oral Biology. 1993; 38: 1057-1063. doi: 10.1016/0003-9969(93)90167-K
74. Samaranayake LP, Tobgi RS, MacFarlane TW. Anti-Candida activity of murine broncho-alveolar lavage fluid. Journal of Medical Microbiology. 1994; 40: 350-357. doi: 10.1099/00222615-40-5-350
75. Sedgley C, Samaranayake LP. The oral prevalence of aerobic and facultative anaerobic gram negative rods and yeasts in Hong Kong Chinese. Archives of Oral Biology. 1994; 39: 459-466. doi:http://dx.doi.org/10.1016/0003-9969(94)90141-4
76. Samaranayake YH, MacFarlane TW, Samaranayake LP, Aitchison, T. The in vitro proteolytic and saccharolytic activity of Candida species in human saliva. Oral Microbiology and Immunology. 1994; 9: 229-235. doi: 10.1111/j.1399-302X.1994.tb00063.x
77. Samaranayake LP, Hamilton D, MacFarlane TW. The effect of indigenous bacterial populations on buccal epithlial cells on subsequent microbial adhesion in vitro. Oral Microbiology and Immunology. 1994; 9: 236-240. doi: 10.1111/j.1399-302X.1994.tb00064.x
78. Samaranayake YH, Wu PC, Samaranayake LP, Yuen KYM. So The adhesion and colonisation of Candida krusei on host surfaces. Journal of Medical Microbiology. 1994; 41: 250-258. doi: 10.1099/00222615-41-4-250
79. Samaranayake YH, Samaranayake LP. Candida krusei: biology, epidemiology. pathogenicity and clinical manifestations of an emerging pathogen. Journal of Medical Microbiology. 1994; 41: 295-310. doi: 10.1099/00222615-41-5-295
80. Reichart P, Schmi dt-Westhausen A, Samaranayake LP, Philipsen HP. Candida-associated palatal papillary hyperplasia in human immunodeficiency virus-infection. Journal of Oral Pathology and Medicine. 1994; 23: 403-405. doi: 10.1111/j.1600-0714.1994.tb00085.x
81. Nikawa H, Samaranayake LP, Tenouvo J, Hamada T. The effect of antifungal agents on the in vitro susceptibility of Candida albicans to apo-lactoferrin. Archives of Oral Biology. 1994; 39: 921-923. doi: http://dx.doi.org/10.1016/0003-9969(94)90026-4
82. Nikawa H, Nishimura H, Yamamoto Y, Hamada T, Samaranayake LP. A novel method to study the hyphal surface hydrophobicity of the dimorphic fungus Candida albicans. Oral Microbiology and Immunology. 1995; 10: 110-114.
83. Tsang PCS, Samaranayake LP, Philipsen HP, et al. Biotypes of oral Candida albicans isolates from diverse geographic locations. Journal of Oral Pathology and Medicine. 1995; 24: 32-36.
84. Nair R, Samaranayake LP, Bhatt M, Anil S. Attitudes and knowledge of Indian dental professionals about HIV infection and AIDS. Community Dentistry Oral Epidemiology. 1995; 23: 187-188. doi: 10.1111/j.1600-0528.1995.tb00227.x
85. Matee MI, Simon E, Christensen MF, et al. Association between carriage of oral yeasts and malnutrition among Tanzanian infants aged 6-24 months. Oral Diseases. 1995; 1: 37-42. doi: 10.1111/j.1601-0825.1995.tb00155.x
86. Dias AP, Samaranayake LP. Clinical, microbiological and ultrastructural features of angular cheilitis lesions in Southeren Chinese. Oral Diseases. 1995; 1: 43-48. doi: 10.1111/j.1601-0825.1995.tb00156.x
87. Xu YY, Samaranayake LP. Oral Candida albicans biotypes in Chinese patients with and without oral candidosis. Archives of Oral Biology. 1995: 40: 577-579. doi:10.1016/0003-9969(94)00196-I
88. Nikawa H, Samaranayake LP, Hamada T. Modulation of the anti-Candida activity of human lactoferrin by dietary sucrose and tunicamycin in-vitro. Archives of Oral Biology. 1995; 40: 581-584. doi: http://dx.doi.org/10.1016/0003-9969(94)00195-H
89. Lumikari LM, Johansson I, Vilja P, Samaranayake LP. Newer saliva collection methods and saliva composition: a study of two Salivette kits. Oral Diseases. 1995; 1: 86-91.
90. Reichart P, Philipsen HP, SchmidtWA, Samaranayake LP. pseudomembranous oral candidiasis in HIV infection: Ultrastructural findings. Journal of Oral Pathology and Medicine. 1995; 24: 276-281. doi: 10.1111/j.1600-0714.1995.tb01182.x
91. Chu CS, Chan TW, Hui HM, et al. The knowledge and attitude of Hong Kong secondary school teachers and students towards the human immunodeficiency virus infection. Community Dental Health. 1995; 12: 110-114.
92. Samaranayake LP, Wilkieson CA, Lamey PJ, MacFarlane TW. Oral disease in the elderly in long-term hospital care. Oral Diseases. 1995; 1: 147-151. doi: 10.1111/j.1601-0825.1995.tb00177.x
93. Matee MIN, Lyamuya EF, Simon EJH, et al. Clincial predictors of HIV-1 infection among pre-school children in Dar-Es-Salaam, Tanzania. East African Medical Journal. 1995; 72(11): 694-698.
94. Sedgley C, Samaranayake LP, Hu EHC, Lee MT. Oral prevalence of aerobic and facultative anaerobic gram negative rods and yeasts in hospitalised patients. Microbial Ecology in Health and Disease. 1995; 8: 225-234. doi: http://dx.doi.org/10.1016/S0003-9969(02)00201-7
95. Xu YY, Samaranayake LP. Biotypes of Candida albicans isolates in Chinese patients with and without oral candidosis. Chinese Journal of Stomatology. 1995: 30: 342-343.
96. Samaranayake YH, Wu PC, Samaranayake LP, So M, Yuen KY. Relationship between the cell surface hydrophobicity and adhesion of Candida krusei and Candid albicans to epithelial and denture acrylic surfaces. Acta Patholgica Microbiologica et Immunologica Scandinavica. 1995; 103: 707-713.
97. Nikawa, H, Nishimura T, Hamada, T, Samaranayake LP. The role of saliva and serum on Candida albicans biofilm formation on denture acrylic. Microbial Ecology in Health and Disease. 1996; 9: 35-48.
98. Nair RG, Samaranayake LP, Philipsen HP, Graham RGB, Itthagarun A. Prevalence of oral lesions in a selected Vietnamese population. Interantional Dental Journal. 1996; 46: 58-51.
99. Sedgley C, Samaranayake LP, Darvell BW. The adherence of oral isolates of enterobacteriaceae to HeLa cells. Acta Patholgica Microbiologica et Immunologica Scandinavica. 1996; 104: 39-46.
100. Wu T, Samaranayake LP, Cao BY, Wang J. In vitro proteinase production by Candida albicans isolates from individuals with and without HIV infection and its attenuation by antimycotics. Journal of Medical Microbiology. 1996; 44: 311-316. doi: 10.1099/00222615-44-4-311
101. Sedgley C, Chu CS, Lo ECM, Samaranayake LP. The oral prevalence of aerobic and facultative anaerobic gram negative rods and yeasts in semi-recluse human vegetarians. Archives of Oral Biology. 1996; 41: 307-309. doi: 10.1016/0003-9969(95)00125-5
102. Zee KY, Pang KM, Samaranayake LP. Bacterial morphotypes of 3-day old plaque in Chinese. Journal of Clinical Periodontology. 1996; 23: 403-406. doi: 10.1111/j.1600-051X.1996.tb00564.x
103. Anil S, Samaranayake LP, Nair RG, Beena VT. Gingival enlargement as a diagnostic indicator in leukaemia. Australian Dental Journal. 1996: 41: 235-237.
104. Nair R, Samaranayake LP. The effect of oral commensal bacteria on candidal adhesion to denture acrylic surfaces: an in vitro study. Acta Pathologica Microbiologica et Immunologica Scandinavica. 1996; 104: 339-349.
105. Nair R, Samaranayake LP. The effect of oral commensal bacteria on candidal adhesion to human buccal epithelial cells. Journal of Medical Microbiology. 1996; 179-185. doi: 10.1099/00222615-45-3-179
106. Matee MIN, Lyamuya EF, Simon EJH, et al. Detection of anti-HIV-1 IgG antibodies in whole saliva by Gacelisa and Western blot assays. East African Medical Journal. 1996; 73: 292-294.
107. Zee KY, Samaranayake LP, Attstrom R, Davies WIR. Predominant cultivable microflora of supragingival dental plaque in Chinese individuals. Archives of Oral Biology. 1996; 41: 647-653. doi: http://dx.doi.org/10.1016/S0003-9969(96)00065-9
108. Matee MIN, Samaranayake LP, Scheutz F, Lyamuya EF, Simon E, Mwinula J. Biotypes of Candida albicans isolates in a Tanzanian child population. Acta Pathologica Microbiologica et Immunologica Scandinavica. 1996; 104: 623-628. doi: 10.1111/j.1699-0463.1996.tb04922.x
109. Sedgley CM, Samaranayake LP, Darvell B. The influence of incubation conditions on the adherence of oral enterobacteriaceae to HeLa cells. Acta Pathologica Microbiologica et Immunologica Scandinavica. 1996; 104: 583-590. doi: 10.1111/j.1699-0463.1996.tb04915.x
110. Zee KY, Samaranayake LP, Attstrom R. Predominant cultivable microflora of supragingival plaque in Chinese `rapid` and `slow` plaque formers. Journal of Clinical Periodontology. 1996; 23: 1025-1031.
111. Cao B, Tsang PW, Samaranayake LP, Wang J. A disc plate assay for characterisation of the effect of interaction between polyenes and azoles on growth of Candida albicans. Microbios. 1996; 87: 161-167.
112. Cao B, Tsang PWK, Wu T, Samaranayake LP, Wang J. Adenine auxotrophic heterozygosity of Candida krusei. Journal of Medical and Veterinary Mycology. 1997; 35: 33-36.
113. Dias AP, Samaranayake LP. Miconazole lacquer in the treatment of denture stomatitis: clinical and microbiological findings in a Chinese cohort. Clinical Oral Investigations. 1997; 1: 47-52. doi: 10.1007/s007840050008
114. Sedgley CM, Samaranayake LP, Chan JCY, Wei SHY. A 4-year longitudinal study of the oral prevalence of aerobic Gram-negative rods and yeasts in Chinese children. Oral Microbiology and Immunology. 1997; 12: 183-188.
115. Scheutz F, Matee MIN, Simon E, Lyamuya EF, Mesengi AE, Samaranayake LP. Association between carriage of oral yeasts, malnutrition, and HIV-1 infection among Tanzanian children aged 18 months to 5 years. Community Dentistry Oral Epidemiology. 1997; 25: 193-198. doi: 10.1111/j.1600-0528.1997.tb00925.x
116. Axell T, Samaranayake LP, Reichart PA, Olsen I. A proposal for reclassification of oral candidosis. Oral Surgery Oral Medicine and Oral Pathology. 1997; 84: 111-112. doi: http://dx.doi.org/10.1016/S1079-2104(97)90049-4
117. Matee MIN, Mesengi AE, Simon E, et al. Nutritional status of under fives attending maternal and child health clinics in Dar-es-salaam, Tanzania. East African Medical Journal. 1997; 74: 368-371.
118. Samaranayake LP, Stassen LF, Still DM. A microbiological study of pre- and postoperative apicectomy sites. Clinical Oral Investigations. 1997; 1: 77-80. doi: 10.1007/s007840050015
119. Samaranayake YH, Samaranayake LP, Wu PC, So M. The antifungal effect of lactoferrin and lysozyme on Candida krusei and Candida albicans. Acta Pathologica Microbiologica Immunologica et Scandinavica. 1997; 105: 875-883.
120. Nikawa H, Nishimura H, Hamada T Kumagai H, Samaranayake LP. Effects of dietary sugars, and saliva and serum on Candida biofilm formation on acrylic surfaces. Mycopathologia. 1997, 139: 87-91.
121. Zee KY, Samaranayake LP. Attstrom R Scanning electron microscopy of microbial colonization of `rapid` and ` slow` plaque formers in vivo. Archives of Oral Biology. 1997; 42: 735-742.
122. Zee KY, Samaranayake LP, Attstrom R. Effect of delmopinol hydrochloride mouthrinse on plaque formation and gingivitis in `rapid` and `slow` plaque formers. Journal of Clinical Periodontology. 1997, 24: 486-491. doi: 10.1111/j.1600-051X.1997.tb00216.x
123. Leung WK, Jin LJ, Samaranayake LP, Chiu GKC. Subgingival microbiota of shallow periodontal pockets in individuals after head and neck irradiation. Oral Microbiology and Immunology. 1998; 13: 1-10. doi: 10.1111/j.1399-302X.1998.tb00743.x
124. Ellepola ANB, Samaranayake LP. The effect of limited exposure to antifungal agents on the germ-tube formation of oral Candida albicans. Journal of Oral Pathology and Medicine. 1998; 27: 213-219. doi: 10.1111/j.1600-0714.1998.tb01944.x
125. Panagoda GJ, Ellepola ANB, Samaranayake LP. Adhesion to denture acrylic surfaces and relative cell surface hydrophobicity of Candida parapsilosis and Candida albicans. Acta Pathologica Microbiologica Immunologica et Scandinavica. 1998; 106: 736-742. doi: 10.1111/j.1699-0463.1998.tb00220.x
126. Ellepola ANB, Samaranayake LP. Adhesion of oral Candida albicans to human buccal epithelial cells following limited exposure to antifungl agents. Journal of Oral Pathology and Medicine. 1998; 27: 325-332. doi: 10.1111/j.1600-0714.1998.tb01964.x
127. Sedgley CM, Samaranayake LP. Antimicrobial susceptibility of oral isolates of Enterobacter cloacae and Klebsiella pneumoniae from a Southern Chinese population. Oral Microbiology and Immunology. 1998; 13: 315-321. doi: 10.1111/j.1399-302X.1998.tb00713.x
128. Samaranayake YH, Wu PC, Samaranayake LP, Ho PL. The relative pathogenicity of Candida krusei and Candida albicans in the rat oral mucosa. Journal of Medical Microbiology. 1998; 47: 1047-1057. doi: 10.1099/00222615-47-12-1047
129. Fernanado PHP, Samaranayake LP. Chromosome length polymorphism in clinical isolates of Candida parasilosis. Acta Pathologica Microbiologica et Immunologica Scandinavica. 1998; 106: 941-946. doi: 10.1111/j.1699-0463.1998.tb00243.x
130. Ellepola ANB, Samaranayake LP. The effect of limited exposure to antimycotics on the relative cell surface hydrophobicity and the adhesion of oral Candida albicans to buccal epithelial cells. Archives of Oral Biology. 1998; 43: 879-887. doi: http://dx.doi.org/10.1016/S0003-9969(98)00064-8
131. Ellepola ANB, Samaranayake LP. The postantifungal effect of antimycotics on oral Candida albicans isolates and its impact on candidal adhesion. Oral Diseases. 1998; 4: 260-267. doi: 10.1111/j.1601-0825.1998.tb00290.x
132. Ellepola ANB, Samaranayake LP. Adhesion of oral Candida albicans isolates to denture acrylic following limited exposure to antifungl agents. Archives of Oral Biology. 1998; 43: 999-1007. doi: 10.1016/S0003-9969(98)00075-2
133. Panagoda JG, Samaranayake LP. The relationship between the cell length, adhesion to acrylic and relative cell srface hydrophobicity of Candida parapsilosis. Medical Mycology. 1998; 36: 373-378. doi: 10.1080/02681219880000591
134. Kuc IM, Samaranayake LP. Van Heyst EN Oral health and microflora in an institutionalised elderly population in Canada. International Dental Journal. 1999; 49: 33-40.
135. Ellepola ANB, Samaranayake LP. The in vitro post-antifungal effect of nystatin on Candida species of oral origin. Journal of Oral Pathology and Medicine. 1999; 28: 112-116. doi: 10.1111/j.1600-0714.1999.tb02007.x
136. Xu YY, Samaranayake YH, Samaranayake LP, Nikawa H. In vitro susceptibility of Candida species to lactoferrin. Medical Mycology. 1999; 37: 35-41. doi: 10.1046/j.1365-280X.1999.00198.x
137. Chen Q, Luo G, Li B, Samaranayake LP. Expression of p16 and CDK4 in oral premalignant lesions and oral squamous cell carcinomas: a semi-quantitative immunohistochemical study. Journal of Oral Pathology and Medicine. 1999; 28: 158-164. doi: 10.1111/j.1600-0714.1999.tb02016.x
138. Tsang PCS, Samaranayake LP. Oral manifestations of HIV infection in a group of predominantly ethnic Chinese cohort. Journal of Oral Pathology and Medicine. 1999, 28: 122-127. doi: 10.4103/0019-5154.60369
139. Yip HK, Samaranayake LP. The ultrastructural topography of the interface between sound and carious dentine after chemomechanical caries removal. Biomedical Letters. 1999: 59: 73-81.
140. Jin LJ, Soder PO, Leung WK, Corbet EF, Samaranayake LP, Davies WIR. Granulocyte elastase activity and PGE leveles in relation to the presence of subgingival periodontopathogens in Chinese adults with untreated periodontitis. Journal of Clinical Periodontology. 1999; 26: 531-540. doi: 10.1034/j.1600-0765.2003.00606.x
141. Wu T, Samaranayake LP, Leung WK, Sullivan PA. Inhibition of growth and secreted aspartyl proteinase production in Candida albicans by lysozyme. Journal of Medical Microbiology. 1999; 48: 721-730. doi: 10.1099/00222615-48-8-721
142. Wu T, Samaranayake LP. The expression of secreted aspartyl proteinase of Candida species in human saliva. Journal of Medical Microbiology. 1999; 48: 711-720. doi: 10.1099/00222615-48-8-711
143. PCS Tsang, Samaranayake LP. Salivary lysozyme and related parameters of HIV-infected individuals in Hong Kong. Oral Diseases. 1999; 5: 241-246. doi: 10.1111/j.1601-0825.1999.tb00308.x
144. Panagoda GJ. Samaranayake LP. A new semi-quantitative techniques for quantification of Candida adherence to denture acrylic surfaces. Mycoses. 1999; 42: 265-267.
145. Tsang PCS, Samaranayake LP. Factors affecting the adherence of Candida albicans to human buccal eothelial cells in human immunodeficiency virus infection. British Journal of Dermatology. 1999; 141: 1-8. doi: 10.1046/j.1365-2133.1999.03158.x
146. Chen Q, Samaranayake LP, Zhen X, Luo G, Nie M, Li B. Up-regulation of Fas ligand and down regulation of Fas expression in oral carcinogenesis. Oral Oncology. 1999; 35: 548-553. doi: http://dx.doi.org/10.1016/S1368-8375(99)00029-9
147. Ellepola ANB, Panagoda JG, Samaranayake LP. The adhesion of oral Candida species to human buccal epithelial cells following breif exposure to nystatin. Oral Microbiology and Immunology. 1999; 14: 358-363. doi: 10.1034/j.1399-302X.1999.140605.x
148. Ellepola ANB, Panagoda JG, Samaranayake LP. In vitro post-antifungal effect (PAFE) elicited by chlorhexidine gluconate on oral isolates of Candida albicans. Microbial Ecology in Health and Disease. 1999; 11: 129-142. doi: 10.1080/089106099435718
149. Nikawa H, Nishimura H, Makihira S, Hamada T, Samaranayake LP. Relationship between thigmotropism and Candida biofilm formation in vitro. Mycopathologia. 1999; 144: 125-129. doi: 10.1023/A:1007073930933
150. Fernanado PHP, Panagoda GJ, Samaranayake LP. The relationship between the acid and alkaline phosphatase activity and the adherence of Candida parapsilosis to human buccal epithelial cells. Acta Pathologica Microbiologica et Immunologica Scandinavica. 1999; 107: 1034-1042. doi: 10.1111/j.1699-0463.1999.tb01507.x
151. Nikawa H, Nishimura H, Hamada T,Yamashiro S, Samaranayake LP. The effect of modified pellicles on Candida biofilm formation on acrylic surfaces. Mycoses. 1999; 42: 37-40. doi: 10.1046/j.1439-0507.1999.00270.x
152. Chen Q Samaranayake LP, Zhou H Xiao L. Homozygous deletion of PTEN tumor suressor gene is not a feature in oral squamous cell carcinoma. Oral Oncology. 2000; 36: 95-99. doi: http://dx.doi.org/10.1016/S1368-8375(99)00068-8
153. Zee KY, Samaranayake LP, Attstrom R. An In vivo replica study of microbial colonization in `rapid` and `slow` dental plaque formers. Acta Pathologica Microbiologica et Immunologica Scandinavica. 2000; 108: 113-121. doi: 10.1034/j.1600-0463.2000.d01-34.x
154. Dassanayake RS, Samaranayake LP.Characterization of the genetic diversity in superficial and sytemic human isolates of Candida parapsilosis by randomly amplified polymorphic DNA. Acta Pathologica Microbiologica et Immunologica Scandinavica. 2000; 108: 153-160. doi: 10.1034/j.1600-0463.2000.d01-39.x
155. Chen Q, Samaranayake LP. The growth of the fungal pathogen Candida in parotid saliva of patients with burning mouth syndrome. Microbios. 2000; 102: 45-52.
156. Egusa H, Ellepola ANB, Nikawa H, Hamada T, Samaranayake LP. Exposure to Sub-therapeutic polyene antimycotics elicits a post-antifungal effect and depresses the cell surface hydrophobicity of oral Candida albicans isolates. Journal of Oral Pathology and Medicine. 2000; 29: 206-213.
157. Leung WK, Dassanayake RS, Joyce YYY, Jin LJ, Yam WC, Samaranayake LP. Oral colonization, phenotypic, and genotypic profiles of Candida species in irradiated, dnetate, xrostomic nasopharyngeal carcinoma survivors. Journal of Clinical Microbiology. 2000; 38: 2219-2226.
158. Nikawa H, Nishimura H, Makihira S, Hamada T,Sadamori S, Samaranayake LP. The effect of serum concentration on Candida biofilm formation on acrylic surfaces. Mycoses. 2000; 43: 139-143. doi: 10.1046/j.1439-0507.2000.00564.x
159. Egusa H, Ellepola ANB, Nikawa H, Hamada T, Samaranayake LP. Exposure to sub-therapeutic concentrations of antifungals suresses the adherence of Candida species to denture acrylic. Chemotherapy. 2000; 46: 267-274.
160. Waltimo TMT, Orstavik, D, Muerman JH, Samaranayake LP, Haapasalo M. In vitro susceptibility of Cnadida albicans isolates from apical and marginal periodontitis to common antifungal agents. Oral Microbiology and Immunology. 2000; 15: 245-248. doi: 10.1034/j.1399-302x.2000.150406.x
161. Ellepola ANB, Samaranayake LP. The effect of brief exposure to sub-therapeutic concentrations of chlorhexidine gluconate on the germ tube formation of Candida albicans and its relationship to post-antifungal effect. Oral Diseases. 2000; 6: 166-171. doi: 10.1111/j.1601-0825.2000.tb00328.x
162. Tsang PCS, Samaranayake LP. Oral yeasts and coliforms in HIV-infected individuals in Hong Kong. Mycoses. 2000; 43: 303-308. doi: 10.1046/j.1439-0507.2000.00584.x
163. Anil S, Ellepola ANB, Samaranayake LP, Beena VT. Tuberculous ulcer of the tongue as presenting feature of pulmonary tuberculosis and HIV infection. General Dentistry. 2000; 458-460.
164. Chus CS, Tsang PCS, Chan AWK, Leung WK, Samaranayake LP, Chan TM. Oral health status, oral microflora and non-surgical periodontal treatment of renal transplant patients receiving cyclosporin A and FK506. Annals of the Royal Australasian College of Dental Surgeon. 2000; 15: 286-291.
165. Dassanayake RS, Samaranayake YH, Samaranayake LP. Genomic diversity of oral Candida krusei isolates as revealed by DNA fingerprinting and electrophoretic karyotyping. APMIS. 2000; 108: 697-704. doi: 10.1034/j.1600-0463.2000.108010697.x
166. Leung WK, Jin LJ, Yam WC, Samaranayake LP. Oral colonization of aerobic and anaerobic gram negative rods and cocci in irradiated, dentate xerostomic individuals. Oral Microbiology and Immunology. 2001; 16: 1-9. doi: 10.1034/j.1399-302x.2001.160101.x
167. WaltimoT, Dassanayake RS, Orstavik D, Haapasalo M, Samaranayake LP. Phenotypes and randomly amplified polymorphic DNA profiles of Candida albicans isolates from root canal infections in a Finnish population. Oral Microbiology and Immunology. 2001; 16: 106-112. doi: 10.1034/j.1399-302x.2001.016002106.x
168. Anil S, Ellepola ANB, Samaranayake LP. The impact of chlorhexidine gluconate on the relative cell surface hydrophobicity of oral Candida albicans. Oral Diseases. 2001, 7: 119-122.
169. Nair RG, Anil S, Samaranayake LP. The effect of oral bacteria on Candida albicans germ-tube formation. APMIS. 2001, 109: 147-154.
170. Samaranayake YH, Samaranayake LP. Experimental oral candidiasis in animal models. Clinical Microbiology Reviews. 2001; 14: 398-429.
171. Samaranayake YH, Samaranayake LP and Yeung KWS. Evaluation of polyene–azole antagonism in liquid cultures of Candida albicans using an automated turbidometric method. Chemotherapy. 2001; 47: 279-291.
172. Panagoda GJ, Ellepola ANB, Samaranayake LP. The adhesion of Candida parapsilosis to epithelial and acrylic surfaces correlates with cell surface hydrophobicity. Mycoses. 2001; 44: 29-35.
173. Shu M, Ellepola ANB, Samaranayake LP. The effect of two different growth media on the post-antifungal effect induced by polyenes on Candida species. Journal of Clinical Microbiology. 2001; 39: 2732-2735.
174. Luo G, Samaranayake LP, Yau JYY. Candida species exhibit differential in vitro haemolytic activities. Journal of Clinical Microbiology. 2001; 39: 2971-2974.
175. Samaranayake YH, Samaranayake LP, Tsang PC, Wong KH, Yeung KWS. Heterogeneity in antifungal susceptibility of clones of Candida albicans isolated on single and sequential visits in a HIV-infected southern Chinese cohort. Journal of Oral Pathology and Medicine. 2001; 30: 336-340.
176. Anil S, Ellepola ANB, Samaranayake LP. Post-antifungal effect of polyene, azole and DNA analogue agents against oral Candida albicans and Candida tropicalis isolates in HIV disease. Journal of Oral Pathology and Medicine. 2001; 30: 481-488. doi:10.1034/j.1600-0714.2001.030008481.x
177. Zee KY, Samaranayake LP, Attstrom R. Salivary immunoglobulin A levels in `rapid` and `slow` plaque formers. Microbios. 2001, 106: 52: 81-87.
178. Samaranayake YH, Samaranayake LP, Pow E, Beena N. The antifungal effect of lysozyme and lactoferrin against genetically similar, sequential Candida albicans isolates from a HIV-infected Southern Chinese cohort. Journal of Clinical Microbiology. 2001; 39: 3296-3302. doi: 10.1128/JCM.39.9.3296-3302.2001
179. Tsang CSP, Samaranayake LP. Predominant cultivable subgingival microbiota of healthy and HIV-infected ethnic Chinese. APMIS. 2001, 117-126. doi: 10.1034/j.1600-0463.2001.d01-113.x
180. Chen Q, Zhou HGuo W, Samaranayake LP,Zhou M, Li B. Correlation between the expression of cyclinA protein and p53 activity in oral squamous cell carcinomas. Cytobios. 2001; 106: 87-99.
181. Anil S, Ellepols ANB, Samaranayake LP. The impact of polyene, azole and DNA analogue antimycotics on the cell surface hydrophobicity of Candida albicans and Candida tropicalis in HIV infection. Mycopathologia. 2001; 153: 179-185. doi: 10.1023/A:1014932302518
182. Makihira S, Nikawa H, Tamagami M, Hamada T, Samaranayake LP. Differences in Candida albicans adhesion to intact and denatured type I collagen in vitro. Oral Microbiology and Immunology. 2002; 17: 129-131. doi: 10.1046/j.0902-0055.2001.00094.x
183. Jin LJ, Leung WK, Corbet EF, Samaranayake LP, Davies WIR, Soder PO. Maximal rate of granulocyte elastase activity in gingival crevicular fluid as a quantitative measure of periodontal conditions. Journal of Peking University (Health Sciences). 2002; 34: 122-132.
184. Dassanayake RS, Ellepols ANB, Samaranayake YH, Samaranayake LP. Molecular heterogeneity of fluconazole resistant and susceptible oral Candida albicans isolates within a single geographic locale. APMIS. 2002; 110: 315-324. doi: 10.1034/j.1600-0463.2002.100406.x
185. Dassanayake RS, Samaranayake LP, Berges T, Cao L. Characterisation, heterologous expression and functional analysis of mavalonate diphospho decarboxylase gene (MVD) of Candida albicans. Molecular genetics and Genomics. 2002; 267: 281-290. doi: 10.1007/s00438-002-0648-7
186. Anil S, Samaranayake LP. Impact of lysozyme and lactoferrin on oral Candida isolates exposed to polyene antimycotics and fluconazole. Oral Diseases. 2002; 8: 199-206. doi: 10.1034/j.1601-0825.2002.01818.x
187. Shen S, Samaranayake LP, Yip HK, Dyson JE. Bacterial and yeast flora of root surface caries in elderly, ethnic Chinese. Oral Diseases. 2002; 8: 207-217. doi: 10.1034/j.1601-0825.2002.01796.x
188. Samaranayake LP, Fidel PL, Naglik JR, et al. Fungal infections associated with HIV infection. Oral Diseases. 2002, 8: 151-160. doi: 10.1034/j.1601-0825.8.s2.6.x
188. Samaranayake LP, Cheung LK, Samaranayake YH. Candidiasis and other fungal diseases of the mouth. Dermatologic Therapy. 2002; 15: 252-270. doi: 10.1046/j.1529-8019.2002.01533.x
189. Reichart P, Samaranayake LP, Grote M, Pow E, Cheung B. High oral prevalence of Candida krusei in leprosy patients in Northern Thailand. Journal of Clinical Microbiology. 2002; 40: 4479-4485. doi: 10.1128/JCM.40.12.4479-4485.2002
190. Kongkunthian P, Isaratanan W, Samaranayake LP, Gelderblom HR, Reichart P. Oro-facial manifestations of Penicillium marneffei infection in a Thai patients with AIDS: case report. Mycoses. 2002 ; 45: 411-414. doi: 10.1046/j.1439-0507.2002.00766.x
191. Reichart PA, Schmidtberg W, Samaranayake LP, Scheifele C. Betel quid-associated oral lesions and oral Candida species in a female Cambodian cohort. Journal of Oral Pathology and Medicine. 2002; 31: 468-472. doi: 10.1034/j.1600-0714.2002.00009.x
192. Nikawa H, Makihira S, Hamada T, Samaranayake LP. Susceptibility of Candida albicans isolates from the oral cavities of HIV-positive patients to histatin-5. Journal of Prosthetic Dentistry. 2002; 88: 263-267. doi: 10.1067/mpr.2002.127907
193. Ellepola ANB, Samaranayake LP. Impact of brief, sequential exposure to fluconazole and amphotericin B on the cell surface hydrophobicity of Candida albicans isolates obtained from HIV-infected patients. Microbial Ecology in Health and Disease. 2002; 14: 153-159.
194. Samaranayake YH, Samaranayake LP, et al. Yeung Adhesion and cell surface hydrophobicity of sequentially isolated genetic isotypes of Candida albicans in an HIV-Infected Southern Chinese cohort. Mycoses. 2002; 46: 375-383. doi: 10.1046/j.0933-7407.2003.00919.x
195. Anil S, Ellepola ANB, Samaranayake LP. The impact of polyene, azole, and DNA analogue antimycotics on the cell surface hydrophobicity of Candida albicans and Candida tropicalis in HIV infection. Mycopathologia. 2002: 153: 179-185.
196. Luo G, Samaranayake LP. Candida glabrata, an emerging fungal pathogen, exhibits superior relative cell surface hydrophobicity and adhesion to denture acrylic surfaces compared with Candida albicans. APMIS. 2002; 110: 601-610. doi: 10.1034/j.1600-0463.2002.1100902.x
197. Leung WK, Yau JYY, Cheung BPK, et al. Oral colonization of aerobic and facultatively anaereobic Gram-negative rods and yeast in Tibetans living in Lhasa. Archives Oral Biology. 2003; 48: 117-123. doi: 10.1016/S0003-9969(02)00201-7
198. Samaranayake YH, Samaranayake LP, Yau JYY, et al. Phenotypic diversity of oral C. albicans isolated on single and sequential visits in a HIV–infected Chinese cohort APMIS. 2003; 111: 329-337. doi: 10.1034/j.1600-0463.2003.1110206.x
199. Samaranayake YH, Samaranayake LP, Yau JYY, et al. `Genotypic shuffling` of Sequential Clones of C. albicans in HIV-infected Individuals With and Without Symptomatic Oral Candidiasis. Journal of Medical Microbiology. 2003; 52: 349-359. doi:10.1099/jmm.0.04972-0
200. Tang G, Yip HK, Luo G Cheung BPK, Samaranayake LP. Development of novel oligonucleotide probes for detecting seven Actinomyces Species and their utility in supragingival plaque analysis Oral Diseases. 2003; 9: 201-209. doi: 10.1034/j.1601-0825.2003.02926.x
201. Anil S, Samaranayake LP. Brief exposure to antimycotics reduces the extracellular phopholipase activity of Candida albicans and Candida tropicalis. Chemotherapy. 2003; 49: 243-247. doi: 10.1159/000072448
202. Tang G, Samaranayake LP, Yip HK, Chu FCS, Tsang PCS, Cheung BPK. Direct detection of Actinomyces species from infected root canals in a Chinese population: a study using a PCR based oligonucleotide DNA hybridization technique. Journal of Dentistry. 2003; 31: 559-568. doi: http://dx.doi.org/10.1016/S0300-5712(03)00112-X
203. Tang G, Yip HK, Samaranayake LP, Luo G, Lo ECM, Teo CS. Actinomyces sp in supragingival plaque of ethnic Chinese preschool children with and without active dental caries Caries Research. 2003; 37: 381-391. doi: 10.1159/000072172
204. Tang G, Yip HK, Luo G, Cheung BP, Shen S, Samaranayake LP. Development of novel oligonucleotide probes for seven Actinomyces species and their utility in supragingival plaque analysis. Oral Diseases. 2003; 9: 203-209doi: 10.1034/j.1601-0825.2003.02926.x
205. Smales FC, Samaranayake LP. Maintaining dental education and specialist dental care during an outbreak of a new coronavirus infection Part 1: A deadly viral epidemic begins British. Dental Journal. 2003; 195: 557-561. doi: 10.1038/sj.bdj.4810723
206. Smales FC, Samaranayake LP. Maintaining dental education and specialist dental care during an outbreak of a new coronavirus infection Part 2: control of the disease, then elimination. British Dental Journal. 2003; 195: 679-681. doi: 10.1038/sj.bdj.4810819
207. Jin Y, Yip HK, Samaranayake YH, Yau JYY, Samaranayake LP. Biofilm-forming ability of Candida albicans is unlikely to contribute to high levels of oral yeast carriage in cases of human immunodeficiency virus infection. Journal of Clinical Microbiology. 2003; 41: 2961-2967. doi: < 10.1128/JCM.41.7.2961-2967.2003 /a>
208. Beighton D, Brailsford S, Samaranayake LP, et al. A multi-country comparison of caries-associated microflora in demographically diverse children. Community Dental Health. 2004; 21: 96-101.
209. CeballosSA, Gaitain C L, CeballosGL, Samaranayake LP. The effect of antiretroviral therapy on the prevalence of HIV-associated oral candidiasis in a Spanish cohort. Oral Surgery Oral Medicine Oral Pathology Oral Radiology. 2004; 97: 343-350. doi:
10.1016/S1079210403006085
210. Pine CM, Adair PM, Nicoll AD, et al. International comparisons of health inequalities in childhood dental caries. Community Dental Health. 2004; 21: 121-130.
211. Waltimo T, Luo G, Samaranayake LP, Vallittu PK. Glass fibre–reinforced composite laced with chlorhexidine diglucoante and yeast adhesion J Materials in Science. Material in Medicine. 2004; 15 117-121. doi:10.1023/B:JMSM.0000011811.15602.3a
212. Tang G, Yip HK, Samaranayake LP, Chan KY, Luo G, Fang HHP. Direct detection of cell surface interactive forces of sessile, fimbriated and non-fimbriated Actinomyces s. using atomic force microscopy. Arch Oral Biol. 2004; 49: 227-238. doi: 10.1016/j.archoralbio.2004.04.003
213. Lu Q, Jin LJ, Darveau P, Samaranayake LP. Expression of human beta defensins-1and -2 peptides in unresolved chronic periodontitis. J Periodont Res. 2004; 39: 221-227.
214. Li R W K, Leung KWC, Sun FCS, Samaranayake LP. Severe Acute Respiratory Syndrome (SARS) and the general dental practitioner Part I : Epidemiology, virology, pathology and general health issues British. Dental Journal. 2004; 197: 77-80. doi: 10.1038/sj.bdj.4811469
215. Nikawa H, Fukushima H, Makihira S, Hamada T, Samaranayake LP. Fungicidal effect of three new synthetic cationic peptides against Candida albicans. Oral Diseases. 2004; 10: 221-228. doi: 10.1111/j.1601-0825.2004.01010.x
216. Luo G, Samaranayake LP, Cheung BPK, Tang G. Reverse transcription polymerase chain reaction (RT-PCR) detection of HLP gene expression in C. glabrata and its possible role in in vitro haemolysin production. APMIS. 2004; 283-290. doi: 10.1111/j.1600-0463.2004.apm11204-0509.x
217. Jin Y, Samaranayake LP, Samaranayake YH, Yip HK. Biofilm Formation of Candida albicans is variably affected by saliva and dietary sugars. Archives of Oral Biology. 2004; 49: 789-798. doi: http://dx.doi.org/10.1016/j.archoralbio.2004.04.011
218. Samaranayake LP, Peiris JSM. Severe acute respiratory syndrome: a retrospective view. Journal of the American Dental Association. 2004; 135: 1292-1301.
219. Tang G, Samaranayake LP and Yip HK. Genotypic diversity of oral Actinomyces naeslundii genospecies 1 and 2 in caries-active preschool children. Oral Microbiol Immunol. 2004; 19: 371-378. doi: 10.1111/j.1399-302x.2004.00171.x
220. Li R WK, Leung KW C, Sun FCS, Samaranayake LP. Severe Acute Respiratory Syndrome (SARS) and the general dental practitioner Part II : Implications for GDP`s British. Dental Journal. 2004; 197: 130-134. doi: 10.1038/sj.bdj.4811522
221. Shen S, Samaranayake LP, Yip HK. In vitro growth properties, acidogenicities and cariogenicities of three bacterial species isolated from human root caries lesions. Journal of Dentistry. 2004; 32: 667-678. doi: http://dx.doi.org/10.1016/j.jdent.2004.07.002
222. Tang G, Samaranayake LP, Yip HK. Molecular evaluation of residual endodontic microorganisms after instrumentation, irrigation and medication with either calcium hydroxide or Septomixine. Oral Diseases. 2004; 10: 389-397. doi: 10.1111/j.1601-0825.2004.01015.x
223. SchmidtWAM, Bendick C, Reichart P, Samaranayake LP. Oral candidiasis and associated Candida species in HIV-infected Cambodians exposed to antimycotics. Mycoses. 2004; 47: 435-441. doi: 10.1111/j.1439-0507.2004.01019.x
224. Hagg U, Kaveewatcharanont P, Samaranayake YH, Samaranayake LP. The effect of orthodontic aliances on the oral carriage of Candida species and emterobacteriacea. European Journal of Orthodontics. 2004; 26: 623-629. doi: http://dx.doi.org/10.1093/ejo/26.6.623
225. Shen, S, Samaranayake LP, YipHK. Coaggregation profiles of the microflora from root surface caries lesions. Archives of Oral Biology. 2005; 50(1): 23-32. doi: 10.1016/j.archoralbio.2004.07.002
226. Samaranayake YH, Ye J, Yau JYY, Cheung BPK, Samaranayake LP. In vitro method to study antifungal perfusion in Candida Biofilms. Journal of Clinical Microbiology. 2005; 43(2): 818-825. doi: : 10.1128/JCM.43.2.818-825.2005
227. Samaranayake LP, Tyas, M, Biffar R, et al. Cutting edge research that will impact future oral health care. International Dental Journal. 2005; 55(1): 45-54.
228. Reichart PA, Khongkhunthian P, Samaranayake LP, Yau J, Patanaporn V, Scheifele C. Oral Candida species and betel quid-associated oral lesions in Padaung women of Northern Thailand. Mycoses. 2005; 48(2): 132-136. doi: 10.1111/j.1439-0507.2004.01071.x
229. Jayatilake JAMS, Samaranayake YH, Samaranayake LP. An ultrastructural and a cytochemical study of candidal invasion of reconstituted human oral epithelium. Journal of Oral Pathology and Medicine. 2005; 34(4): 240-246. doi: 10.1111/j.1600-0714.2005.00307.x
230. Jin Y, Zhang T, Samaranayake YH, et al. The use of new probes and stains for improved assessment of cell viability and extracellular polymeric substances in Candida albicans biofilms. Mycopathologia. 2005; 159(3): 353-360. doi: http://dx.doi.org/10.1007/s11046-004-6987-7
231. Chen L, Wong MP, Cheung LK, Samaranayake LP, Baum L, Samman N. Frequent allelic loss of 21q11.1∼q21.1 region in advanced stage oral squamous cell carcinoma. Cancer Genetics and Cytogenetics. 2005; 159(1): 37-43. doi: 10.1016/j.cancergencyto.2004.09.011
232. Chu FCS, Tsang CSP, Chow TW, Samaranayake LP. Identification of cultivable microorganisms from primary endodontic infections with exposed and unexposed pulp space. Journal of Endodontics. 2005; 31(6): 424-429. doi: 10.1097/01.don.0000148149.27636.9c
233. Samaranayake YH, Dassanayake RS, Jayatilake JAMS, et al. Phospholipase B enzyme expression is not associated with other virulence attributes in Candida albicans isolates from patients with human immunodeficiency virus infection. Journal of Medical Microbiology. 2005; 54(6): 583-593. doi: 10.1099/jmm.0.45762-0
234. Jin, Y, Samaranayake YH, Yip, H.K, Samaranayake LP. Characterization of switch phenotypes in Candida albicans biofilms. Mycopathologia. 2005; 160(3): 191-200. doi: 10.1007/s11046-005-6331-x
235. Brook I, Lewis MAO, et al. Clindamycin in dentistry: More than just effective prophylaxis for endocarditis?. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics. 2005; 100(5): 550-558. doi: 10.1016/j.tripleo.2005.02.086
236. Lu Q, Samaranayake LP, Darveau RP, Jin L. Expression of human β-defensin-3 in gingival epithelia. Journal of Periodontal Research. 2005; 40(6): 474-481. doi: 10.1111/j.1600-0765.2005.00827.x
237. Chu FCS, Leung WK, Tsang PCS, et al. Identification of cultivable microorganisms from root canals with apical periodontitis following two-visit endodontic treatment with antibiotics/steroid or calcium hydroxide dressings Journal of Endodontics. 2006; 32(1): 17-23. doi: 10.1016/j.joen.2005.10.014
238. Meurman JH, Kari K, Waltimo T, Kotiranta A, Inkeri,J, Samaranayake LP. In vitro antifungal effect of amine fluoride-stannous fluoride combination on oral Candida species. Oral Diseases. 2006; 12(1): 45-50. doi: 10.1111/j.1601-0825.2005.01156.x
239. He XY, MeurmanJH, Kari K, Rautemaa R, Samaranayake LP. In vitro adhesion of Candida species to denture base materials. Mycoses. 2006; 49(2): 80-84. doi: 10.1111/j.1439-0507.2006.01189.x
240. Parahitiyawa NB, Samaranayake YH, Samaranayake LP, et al. Interspecies variation in Candida biofilm formation studied using the Calgary biofilm device APMIS. 2006; 114(4): 298-306. doi: 10.1111/j.1600-0463.2006.apm_394.x
241. McGrath C, Comfort MB, Luo Y, et al. Alication of an interactive computer program to manage a problem-based dental curriculum. Journal of Dental Education. 2006; 70(4): 387-397.
242. Soysa NS, Samaranayake LP, Ellepola ANB. Diabetes mellitus as a contributory factor in oral candidosis. Diabetic Medicine. 2006; 23(5): 455-459. doi: 10.1111/j.1464-5491.2005.01701.x
243. Coogan MM, Fidel PL, Komesu MC, MaedaN, Samaranayake LP. (B1) Candida and Mycotic Infections. Advances in Dental Research. 2006; 19(1): 130-138. doi: 10.1177/154407370601900124
244. Thein ZM, Samaranayake YH, Samaranayake LP. Effect of oral bacteria on growth and survival of Candida albicans biofilms. Archives of Oral Biology. 2006; 51(8): 672-680. doi: 10.1016/j.archoralbio.2006.02.005
245. Lu, Q, Jayatilake, JAMS, Samaranayake LP, Jin L. Hyphal invasion of Candida albicans inhibits the expression of human β-defensins in experimental oral candidiasis. Journal of Investigative Dermatology. 2006; 126(9): 2049-2056. doi: 10.1038/sj.jid.5700346
246. Jayatilake JAMS, Samaranayake YH, Cheung LK, Samaranayake LP. Quantitative evaluation of tissue invasion by wild type, hyphal and SAP mutants of Candida albicans, and non-albicans Candida species in reconstituted human oral epithelium. Journal of Oral Pathology and Medicine. 2006; 35(8): 484-491. doi: 10.1111/j.1600-0714.2006.00435.x
247. Samaranayake YH, Dassanayake RS, Cheung BPK, et al. Differential phospholipase gene expression by Candida albicans in artificial media and cultured human oral epithelium APMIS. 2006; 114(12): 857-866. doi: 10.1111/j.1600-0463.2006.apm_479.x
248. Ariyawardana A, Panagoda GJ, Fernando HN, et al. Oral submucous fibrosis and oral yeast carriage - A case control study in Sri Lankan patients. Mycoses. 2007; 50(2): 116-120. doi: 10.1111/j.1439-0507.2006.01330.x
249. Yip HKK, Tsang PCS, Samaranayake LP, Li AHP. Knowledge of and attitudes toward severe acute respiratory syndrome among a cohort of dental patients in Hong Kong following a major local outbreak Community Dental Health. 2007; 24(1): 43-48.
250. Jayatilake JAMS, Samaranayake LP, Lu Q, Jin LJ. IL-1α, IL-1ra and IL-8 are differentially induced by Candida in experimental oral candidiasis. Oral Diseases. 2007; 13(4): 426-433. doi: 10.1111/j.1601-0825.2007.01318.x
251. Reichart PA, Samaranayake LP, Bendick Ch, et al. Prevalence of oral Candida species in leprosy patients from Cambodia and Thailand. Journal of Oral Pathology and Medicine. 2007; 36(6): 342-346. doi: 10.1111/j.1600-0714.2007.00535.x
252. Thein ZM, Samaranayake YH, Samaranayake LP. In vitro biofilm formation of Candida albicans and non-albicans Candida species under dynamic and anaerobic conditions. Archives of Oral Biology. 2007; 52(8): 761-767. doi: 10.1016/j.archoralbio.2007.01.009
253. Mendes A, Mores AU, Carvalho AP, et al. Candida albicans biofilms produce more secreted aspartyl protease than the planktonic cells Biological and Pharmaceutical Bulletin. 2007; 30(9): 1813-1815. doi: http://dx.doi.org/10.1248/bpb.30.1813
254. Tsang CSP, Chu FCS, Leung WK, et al. Phospholipase, proteinase and haemolytic activities of Candida albicans isolated from oral cavities of patients with type 2 diabetes mellitus. Journal of Medical Microbiology. 2007; 56(10): 1393-1398. doi: 10.1099/jmm.0.47303-0
255. Thein ZM, Samaranayake YH, Samaranayake LP. Dietary sugars, serum and the biocide chlorhexidine digluconate modify the population and structural dynamics of mixed Candida albicans and Escherichia coli biofilms. APMIS. 2007; 115(11): 1241-1251. doi: 10.1111/j.1600-0643.2007.00735.x
256. Thein ZM, Samaranayake YH, Samaranayake LP. Characteristics of dual species Candida biofilms on denture acrylic surfaces Archives of Oral Biology. 2007; 52(12): 1200-1208. doi: 10.1016/j.archoralbio.2007.06.007
257. Seneviratne CJ, Wong RWK, Samaranayake LP. Potent anti-microbial activity of traditional Chinese medicine herbs against Candida species. Mycoses. 2008; 51(1): 30-34. doi: 10.1111/j.1439-0507.2007.01431.x
258. Zhu HW, McMillanAS, McGrath C, Li, LSW, Samaranayake LP. Oral carriage of yeasts and coliforms in stroke sufferers: A prospective longitudinal study. Oral Diseases. 2008; 14(1): 60-66. doi: 10.1111/j.1601-0825.2006.01347.x.
259. Soysa NS, Samaranayake LP, Ellepola ANB. Antimicrobials as a contributory factor in oral candidosis - A brief overview. Oral Diseases. 2008; 14(2): 138-143. doi: 10.1111/j.1601-0825.2006.01357.x.
260. Lee W, Low BKM, Samaranayake LP, Hagg U. Genotypic variation of Candida albicans during orthodontic therapy Frontiers in Bioscience. 2008; 13(10): 3814-3824.
261. Jayatilake JAMS, Samaranayake YH, Samaranayake LP. A comparative study of candidal invasion in rabbit tongue mucosal explants and reconstituted human oral epithelium Mycopathologia. 2008; 165(6): 373-380. doi: 10.1007/s11046-008-9096-1
262. Leung WK, Siu SC, Chu FCS, et al. Oral health status of low-income, middle-aged to elderly Hong Kong Chinese with Type 2 diabetes mellitus. Oral Health & Preventive Dentistry. 2008; 6: 105-118.
263. M CM Thiele AP, Carvalho LC, Gursky RT, et al. The role of candidal histolytic enzymes on denture induced stomatitis in patients living in retirement homes. Gerodontology. 2008; 25: 229-236. doi: 10.1111/j.1741-2358.2008.00221.x
264. Egusa H, Soysa N, et al. Oral candidosis in HIV-infected patients. Current HIV Research. 2008; 6(6): 485-499. doi: 10.2174/157016208786501445
265. Rosa EAR, Ribeiro DA, Nunes RR, et al. Phenotypic evaluation of the effect of anaerobiosis on some virulence attributes of Candida albicans. Journal of medical microbiology. 2008; 57(10): 1277-1281. doi: 10.1099/jmm.0.2008/001107-0
266. Seneviratne CJ, Jin LJ, Samaranayake YH, Samaranayake LP. Cell density and cell aging as factors modulating antifungal resistance of Candida albicans biofilms. Antimicrobial agents and chemotherapy. 2008; 52(9): 3259-3266. doi: 10.1128/AAC.00541-08.
267. Seneviratne C, et al. Candida albicans biofilm formation is associated with increased anti-oxidative capacities. Proteomics. 2008; 8(14): 2936-2947. doi: 10.1002/pmic.200701097
268. Parahitiyawa NB, Jin LJ, Leung WK, Yam WC, Samaranayake LP. Microbiology of Odontogenic Bacteremia: beyond Endocarditis. Clinical Microbiology Reviews. 2009; 22: 46-64. doi:10.1128/CMR.00028-08.
269. Sitheeque MA, Panagoda GJ, Yau J, Amarakoon AM, Udagama UR, Samaranayake LP. Antifungal Activity of Black Tea Polyphenols (Catechins and Theaflavins) against Candida Species. Chemotherapy. 2009, 55: 189-196. doi: 10.1159/000216836
270. Meurman JH, et al. Effect of amine fluoride-stannous fluoride preparations on oral yeasts in the elderly: a randomised placebo-controlled trial. Gerodontology. 2009; 26: 202-209. doi: 10.1111/j.1741-2358.2008.00246.x
271. Samaranayake LP. Commensal oral Candida in Asian cohorts. International journal of oral science. 2009; 1(1): 2-5. doi: 10.4248/ijos.08006.
272. Hibino K, Wong RW, Hägg U, Samaranayake LP. The effects of orthodontic appliances on Candida in the human mouth. Int J Paediatr Dent. 2009; 19(5): 301-305. doi: 10.1111/j.1365-263X.2009.00988.x
273. Mores AU, Souza RD, Cavalca L, et al. Enhancement of Secretory Aspartyl Protease production in biofilms of Candida albicans exposed to sub-inhibitory concentrations offluconazole. Mycoses. 2009. doi: 10.1111/j.1439-0507.2009.01793.x.
274. Thein ZM, Seneviratne CJ, Samaranayake YH, Samaranayake LP. Community lifestyle of Candida in mixed biofilms: a mini review. Mycoses. 2009; 52(6): 467-475. doi: 10.1111/j.1439-0507.2009.01719.x
275. Taniguchi L,, Rosa RT, Gursky LC, et al. Proposal of a low-cost protocol for colorimetric semi-quantification of secretory phospholipase by Candida albicans grown in planktonic and biofilm phases. J Microbiol Methods. 2009; 78(2): 171-174. doi: 10.1016/j.mimet.2009.05.012
276. Hibino K, Samaranayake LP, Hagg U, Wong RW, Lee W. The role of salivary factors in persistent oral carriage of Candida in humans. Arch Oral Biol. 2009; 54(7): 678-683. doi: 10.1016/j.archoralbio.2009.04.003.
277. Baboni FB, Barp D, Izidoro AC, Samaranayake LP, Rosa EA. Enhancement of Candida albicans virulence after exposition to cigarette mainstream smoke. Mycopathologia. 2009; 168(5): 227-235. doi: 10.1007/s11046-009-9217-5
278. Seneviratne CJ, Silva WJ, Jin LJ, Samaranayake YH, Samaranayake LP. Architectural analysis, viability assessment and growth kinetics of Candidaalbicans and Candida glabrata biofilms. Arch Oral Biol. 2009; 54(11): 1052-1060. doi: 10.1016/j.archoralbio.2009.08.002
279. Lu Q, Darveau RP, Samaranayake LP, Wang CY, Jin L. Differential modulation of human {beta}-defensins expression in human gingival epithelia by Porphyromonas gingivalis lipopolysaccharide with tetra- and penta-acylated lipid A structures. Innate Immun. 2009; 15(6): 325-335. doi: 10.1177/1753425909104899
280. Bandara HM, Yau JY, Watt RM, Jin LJ, Samaranayake LP. Escherichia coli and its lipopolysaccharide modulate in vitro Candida biofilm formation. J Med Microbiol. 2009; 58(12): 1623-1631. doi: 10.1099/jmm.0.012989-0
281. de Souza RD, Mores AU, Cavalca L, Rosa RT, Samaranayake LP, Rosa EA. Cellsurface hydrophobicity of Candida albicans isolated from elder patients undergoing denture-related candidosis. Gerodontology. 2009; 26(2): 157-161. doi: 10.1111/j.1741-2358.2008.00229.x.
282. Cecon F, Ferreira LE, Rosa RT, et al. Time-related increase of staphylococci, Enterobacteriaceae and yeasts in the oral cavities of comatose patients. J Microbiol Immunol Infect. 2010; (6): 457-463. doi: 10.1016/S1684-1182(10)60071-0
283. Low B, Lee W, Seneviratne CJ, Samaranayake LP, Hagg U. Ultrastructure and morphology of biofilms on thermoplastic orthodontic aliances in fast and slow plaque formers. Eur J Orthod. 2010; 33: 577-583. doi: 10.1093/ejo/cjq126
284. Lam OL, Zhang W, Samaranayake LP, Li LS, McGrath C. A systematic review of the effectiveness of oral health promotion activities among patients with cardiovascular disease. Int J Cardiol. 2010; 15: 261-267. doi: 10.1016/j.ijcard.2010.11.014
285. Carvalho AP, Gursky LC, Rosa RT, et al. Non-steroidal anti-inflammatory drugs may modulate the protease activity of Candida albicans. Microb Pathog. 2010; 49(6): 315-322. doi: 10.1016/j.micpath.2010.07.007
286. Perera M, Tsang CS, Distel RJ, et al. TGF-beta1interactome: metastasis and beyond. Cancer Genomics Proteomics. 2010; 7: 217-219.
287. Perera RA, Samaranayake LP, Tsang CS. Shedding dynamics of Epstein-Barr virus: A type 1 carcinogen. Arch Oral Biol. 2010; 55(9): 639-647. doi: 10.1016/j.archoralbio.2010.06.009
288. Meurman JH, Parnanen P, Seneviratne CJ, Samaranayake LP, Saarinen AM, Kari K. Prevalence and antifungal drug sensitivity of non-albicans Candida in oral rinsesamples of self-caring elderly. Gerodontology. 2010. doi: 10.1111/j.1741-2358.2010.00407.x
289. Bandara HM, Lam OL, Watt RM, Jin LJ, Samaranayake LP. Bacterial lipopolysaccharides variably modulate in vitro biofilm formation of Candida species. J Med Microbiol. 2010; 59: 1225-1234. doi: 10.1099/jmm.0.021832-0
290. da Silva WJ, Seneviratne J, Samaranayake LP, Del BCAA. Bioactivity and architecture of Candida albicans biofilms developed on poly(methyl methacrylate) resin surface. J Biomed Mater Res B Al Biomater. 2010; 149-156. doi: 10.1002/jbm.b.31635
291. Bandara HM, Yau JY, Watt RM, Jin LJ, Samaranayake LP. Pseudomonas aeruginosa inhibits in-vitro Candida biofilm development. BMC Microbiol. 2010; 10: 125. doi: 10.1186/1471-2180-10-125
292. Jayatilake JA, Samaranayake LP. Experimental superficial candidiasis on tissue models. Mycoses. 2010; 53(4): 285-295. doi: 10.1111/j.1439-0507.2010.01879.x
293. Seneviratne CJ, Wang Y, Jin L, Abiko Y, Samaranayake LP. Proteomics of drug resistance in Candida glabrata biofilms. Proteomics. 2010 ; 10(7): 1444-1454. doi: 10.1002/pmic.200900611
294. Samaranayake YH, Yau JY, Thein ZM, Jayatilake JA, Yeung KW, Samaranayake LP. The post-antifungal effect (PAFE) of amphotericin B, nystatin, ketoconazole and 5-fluorocytosine and its impact on the colonization traits of Candida glabrata. Med Mycol. 2010; (5): 725-734. doi: 10.3109/13693780903496583
295. Watamoto T, Samaranayake LP, Egusa H, Yatani H, Samaranayke YH, Seneviratne CJ. Susceptibility of Candida albicans filamentation-defective mutants to clinical biocides. J Hosp Infect. 2010; 74(2): 189-191. doi: 10.1016/j.jhin.2009.10.017
296. Ajonuma L, Lu Q, Cheung BP, Leung WK, Samaranayake LP, Jin L. Expression and localization of cystic fibrosis transmembrane conductance regulator in humangingiva. Cell Biol Int. 2010; 34(2): 147-152. doi: 10.1042/CBI2009/0019
297. Tsang CS, Samaranayake LP. Immune reconstitution inflammatory syndrome after highly active antiretroviral therapy: a review. Oral Dis. 2010; 16(3): 248-256. doi: 10.1111/j.1601-0825.2009.01628.x
298. Parahitiyawa NB, Scully C, Leung WK, Yam WC, Jin LJ, Samaranayake LP. Exploring the oral bacterial flora: current status and future directions. Oral Dis. 2010; 16(2): 136-145. doi: 10.1111/j.1601-0825.2009.01607.x
299. Kang K, Wong KS, Seneviratne CJ, Samaranayake LP, Fong WP, Tsang PW. In vitro synergistic effects of metergoline and antifungal agents against Candida krusei. Mycoses. 2010; 53(6): 495-499. doi: 10.1111/j.1439-0507.2009.01747.x
300. Pärnänen Pirjo, Meurman Jukka H, Lakshman S, Ismo V. Human oral keratinocyte E-cadherin degradation by Candida albicans and Candida glabrata. Journal of oral Pathology & Medicine. 2010; 39(3): 275-278. doi: 10.1111/j.1600-0714.2009.00866.x
301. Seneviratne CJ, Zhang CF, Samaranayake LP. Dental plaque biofilm in oral health and disease. Chin J Dent Res. 2011; 14: 87-94.
302. Gao XL, Seneviratne CJ, Lo EC, Chu CH, Samaranayake LP. Novel and conventional assays in determining abundance of Streptococcus mutans in salivaInt. J Paediatr Dent. 2011. doi: 10.1111/j.1365-263X.2011.01207.x
303. Chen Y, Wong RW, Seneviratne CJ, Hägg U, McGrath C, Samaranayake LP. Comparison of the antimicrobial activity of Listerine and Corsodyl on orthodontic brackets in vitro. Am J Orthod Dentofacial Orthop. 2011; 140: 537-542. doi: 10.1016/j.ajodo.2011.01.022
304. Seneviratne CJ, Wong SS, Yuen KY, et al. Antifungal susceptibility and virulence attributes of bloodstream isolates of Candida from Hong Kong and Finland. Mycopathologia. 2011; 172: 389-395. doi: 10.1007/s11046-011-9444-4
305. Watamoto T, Samaranayake LP, Egusa H, Yatani H, Seneviratne CJ. Transcriptional regulation of drug-resistance genes in Candida albicans biofilms in response to antifungals. J Med Microbiol. 2011; 60: 1241-1247. doi: 10.1099/jmm.0.030692-0
306. Chen Y, Wong RW, Seneviratne CJ, et al. The antimicrobial efficacy of Fructus mume extract on orthodontic bracket: a monospecies-biofilm model study in vitro. Arch Oral Biol. 2011; 56: 16-21. doi: 10.1016/j.archoralbio.2010.08.006
307. Meurman JH, Pärnänen P, Seneviratne CJ, Samaranayake LP, Saarinen AM, Kari K. Prevalence and antifungal drug sensitivity of non-albicans Candida in oral rinse samples of self-caring elderly. Gerodontology. 2011; 28: 246-252. doi: 10.1111/j.1741-2358.2010.00407.x
308. Mores AU, Souza RD, Cavalca L, et al. Enhancement of secretory aspartyl protease production in biofilms of Candida albicans exposed to sub-inhibitory concentrations of fluconazole. Mycoses. 2011; 54: 195-201. doi: 10.1111/j.1439-0507.2009.01793.x
309. Samaranayak YH, Cheung BPK, Yau JYY, Yeung KW, Samaranayake LP. Genotypic, phenotypic, and proteomic characterization of Candida glabrata during sequential fluconazole exposure. Journal of Investigative and Clinical Dentistry. 2011; 2: 117-127. doi: 10.1111/j.2041-1626.2011.00044.x
310. Seneviratne CJ, Wang Y, Jin L, Wong SS, Herath TD, Samaranayake LP. Unraveling the resistance of microbial biofilms: has proteomics been helpful?. Proteomics. 2012; 12: 651-665. doi: 10.1002/pmic.201100356
311. Lam OL, McGrath C, Bandara HM, Li LS, Samaranayake LP. Oral health promotion interventions on oral reservoirs of Staphylococcus aureus: a systematic review. Oral Dis. 2012; 18(3): 244-254. doi: 10.1111/j.1601-0825.2011.01874.x
312. de Azevedo Izidoro AC, Semprebom AM, Baboni FB, et al. Low virulent oral Candida albicans strains isolated from smokers. Arch Oral Biol. 2012; 57: 148-153. doi: 10.1016/j.archoralbio.2011.08.016.
313. Lam OL, Bandara HM, Samaranayake LP, McGrath C, Li LS. Oral health promotion interventions on oral yeast in hospitalised and medically compromised patients: a systematic review. Mycoses. 2012; 55: 123-142. doi: 10.1111/j.1439-0507.2011.02062.x.
314. Lam OL, McGrath C, Li LS, Samaranayake LP. Effectiveness of oral hygiene interventions against oral and oropharyngeal reservoirs of aerobic and facultatively anaerobic gram-negative bacilli. Am J Infect Control. 2012; 40: 175-182. doi: 10.1016/j.ajic.2011.03.004
315. Yan Z, Hua H, Xu Y, Samaranayake LP. Potent Antifungal Activity of Pure Compounds from Traditional Chinese Medicine Extracts against Six Oral Candida Species and the Synergy with Fluconazole against Azole-Resistant Candida albicans. Evid Based Complement Alternat Med. 2012; 2012: 106583. doi: http://dx.doi.org/10.1155/2012/106583
316. Da Silva WJ, Gonçalves LM, Seneviratne J, et al. Exopolysaccharide matrix of developed Candida albicans biofilms after exposure to antifungal agents Brazilian. Dental Journal. 2012; 23(6): 716-722.
317. Gao XL, Seneviratne CJ, Lo EC, Chu CH, Samaranayake LP. Novel and conventional assays in determining abundance of Streptococcus mutans in saliva. International Journal of Paediatric Dentistry. 2012; 22(5): 363-368. doi: 10.1111/j.1365-263X.2011.01207.x
318. Mei ML, Li QL, Chu CH, Lo ECM, Samaranayake LP. Antibacterial effects of silver diamine fluoride on multi-species cariogenic biofilm on caries. Annals of Clinical Microbiology and Antimicrobials. 2013; 12(1): 4doi: 10.1186/1476-0711-12-4
319. Bandara HMHN, Cheung K, et al. Pseudomonas aeruginosa lipopolysaccharide inhibits Candida albicans hyphae formation and alters gene expression during biofilm development Molecular. Oral Microbiology. 2013; 28(1): 54-69. doi: 10.1111/omi.12006
320. Samaranayake YH, Cheung BPK, Wang Y, et al. Fluconazole resistance in Candida glabrata is associated with increased bud formation and metallothionein production. Journal of Medical Microbiology. 2013; 62: 303-318. doi: 10.1099/jmm.0.044123-0
321. Lam OLT, McMillan AS, Samaranayake LP, Li LSW, McGrath C. Effect of oral hygiene interventions on oortunistic pathogens in patients after stroke. American Journal of Infection Control. 2013; 41(2): 149-154. doi: 10.1016/j.ajic.2012.02.020
322. Javed F, Al-Askar M, Samaranayake LP, Al-Hezaimi K. Periodontal disease in habitual cigarette smokers and nonsmokers with and without prediabetes. American Journal of the Medical Sciences. 2013; 345(2): 94-98. doi: 10.1097/MAJ.0b013e31824d5337
323. Chen Y, Wong RWK, Seneviratne CJ, Hagg U, Mcgrath C, Samaranayake LP. The effects of natural compounds-containing mouthrinses on patients with fixed orthodontic aliance treatment: Clinical and microbiological outcomes. International Journal of Paediatric Dentistry. 2013. doi: 10.1111/ipd.12018
324. Mei L, Chu CH, Lo ECM, Samaranayake LP. Fluoride and silver concentrations of silver diammine fluoride solutions for dental use. International Journal of Paediatric Dentistry. 2013; 23: 279-285. doi: 10.1111/ipd.12005
325. Mei L, Chu CH, Lo ECM, Samaranayake LP. Preventing root caries development under oral biofilm challenge in an artificial mouth. Medicina Oral Patologia Oral Y Cirugia Bucal. 2013; 18: e557-e563. doi: 10.4317/medoral.18768
326. Samaranayake YH, Cheung BPK, Wang Y, Yau JYY, Yeung SKW, Samaranayake LP. Fluconazole resistance in Candida glabrata is associated with increased bud formation and metallothionein production. Journal of Medical Microbiology. 2013; 62(2): 303-318. doi: 10.1099/jmm.0.044123-0
327. Panduwawala KC, Samaranayake LP, Jin L and Zhang C. Human umbilical vein endothelial cells synergize osteo/odontogenic differentiation of periodontal ligament stem cells in 3D cell sheets. Journal of Periodontal Research. 2013; 49(3): 299-306. doi: 10.1111/jre.12107
328. Samaranayake YH, Cheung BPK, Yau JYY, Yeung SKW, Samaranayake LP. Human Serum Promotes Candida albicans Biofilm growth and Virulence Gene Expression on Silicone Biomaterial. PLoS One. 2013; 8(5): e62902. doi: 10.1371/journal.pone.0062902
329. Samaranayake YH, Bandara HMHN, Cheung BPK, Yau JYY, Yeung SKW, Samaranayake LP. Enteric gram-negative bacilli suress Candida biofilms on Foley urinary catheters. APMIS : acta pathologica, microbiologica et immunologica Scandinavica. 2013; 122(1): 47-58. doi: 10.1111/apm.12098
330. Lam OLT, McMillan AS, Samaranayake LP, Li LS, McGrath CPJ. Randomized Clinical Trial of Oral Health Promotion Interventions Among Patients Following Stroke. Archives of Physical Medicine and Rehabilitation. 2013; 94: 435-443. doi:10.1016/j.apmr.2012.10.024
331. Samaranayake L. Oral health, dental education and research: a commentary. Dent Open J. 2015; 2(3): 74-76. doi: 10.17140/DOJ-2-114

Vinayak Raghunathan, MDS

Assistant Professor
The Oxford Dental College
Bangalore, India

BiographyResearch InterestScientific ActivitiesPublications

• Currently, working as Assistant Professor in the Department of Periodontics , The oxford dental college, Bangalore, India
• Currently, working as principal investigator in M.S.Clinical Research (Dental unit), Bangalore, India
• Recently , received university grants of 4499 USD ( Rs.3 lakhs ) to conduct a dental implant study using Inductively coupled plasma mass spectrometry
• Currently , holding the post of Editor-in-Chief in the Journal of Dentistry and Oral implants
• Currently ,holding the post as an Indian Co-ordinator for POSEIDO academic network
• Have been the chairperson in 68th Indian Dental Conference, Bangalore, India.
• Won the Best Paper award for the study entitled “Like IOPA , Like CBCT”. in 68th Indian Dental Conference, Bangalore , India
• Have been associated with various national and international journals as a Reviewer

His research interest includes Implantology.

 Lasers in periodontics. 10th Indian Society of Periodontology, P.G Convention, Chennai
 Regenerative Periodontal endoscopy : Feel the future. 13th ISP Postgraduate convention, Lucknow
 The concept of MAX implants in Implantology. 1St ISOI Symposium, Bangalore
 Public awareness and knowledge about dental implants : A Bi-lingual questionnaire based study. 14th ISP Postgraduate convention, Noida

1. Reddy S, Kaul S, Prasad MGS, Agnihotri J, Amudha D, Vinayak R. Interlink between stress and periodontal disease. Health Renaissance HREN. 2012; 10(2): 126-131. doi: 10.3126/hren.v10i2.6579
2. Comparison of periodontal flap surgery with/without removal of pocket epithelium. J Indian Society Periodontol. 2014; 18(6).
3. Comparing 0.1% chlorhexidine mouthwash with 0.2% chlorhexidine mouthwash for reduction of plaque, gingivitis and discolouration: A Parallel single blind study ( Under review in Journal of the International Clinical Dental Research )
4. Sanjay Kaul, Shantipriya Reddy, Soumya Kambali, et al. The socket science of immediate implants: A Case report. Int J Health Sci Res. 2014; 4(2): 184-190. Web site. http://www.scopemed.org/?mno=152991.
5. Amlodipine - Induced Gingival growth-A case report. Int J Health Sci Res. 2014; 4(5).
6. “Probiotics in the treatment of periodontal disease: A systematic review” submitted to International Journal of Dentistry.