Shaw Watanabe, MD, PhD
Life Science Promotion Foundation
25-3-1004, Daikyo-cho, Shinjuku-ku
Tokyo 160-0005, Japan
Dr. Watanabe had graduated from Keio University, School of Medicine in 1965, and got his Doctors degree in 1970. He had worked as a Assistant Professor, Department of Pathology, Keio University School of Medicine during 1973 and 1977, Visiting Scientist of National Cancer Institute, USA (1975-1976), Section Head of Pathology Division and Director of Epidemiology Division, National Cancer Center (1985-1996). He had also worked as a Professor and Chairman, Department of Nutrition and Epidemiology, Tokyo University of Agriculture (1995-2005), and Director General, National Institute of Health and Nutrition (2005-2009). At Present, he is the President of Life Science Promoting Association since 2009. He is also the President of the Society of National Integrated Medicine (2011-Present). He was the President of APCCN 2014 in Tokyo in 2013 and the Chairman of the East Asia Conference on Standardization of Rice Function in Kyoto in 2014. He is the chief editor of the Clinical and Functional Nutriology and the Life Science in Japan.
He was an emeritus member of the Japan Pathological Society, Japan Epidemiology Society, Japan Cancer Society, Society of Functional Food Factors, etc. He had done more than 2000 autopsy as pathologist, had built population based prospective cohort study (JPHC study), contributed to expand shoku-iku (eating education) as a chairman.
He was also one of the scientific board members in the Ministry of Health, Labour and Welfare, Ministry of Agriculture, Forest and Fishery, Cabinet Office and Environmental Agency.
His research interests include: Dietary treatment, Physical activity to control the diabetes.
• (1970) Medical Doctor Liscence No.‚ P‚ W‚ X‚ W‚ O‚ X
• (1973) Licensed Anatomical Pathologist Liscence No.‚ Q‚ Q‚ U‚ V
• (1979) Leader, Surgical Pathologist Liscence No. 429
• Leader, Society of Pathological Nutrition
• WHO consultant on Tobacco or Health
• (1990-1995) IARC Fellowship Selection Committee Member
• Workshop member of dioxin toxicity, IARC
• Chairman, Shokuiku Promotion, Cabinet Office, Japan
• (2006-2007) Chairman, Chemical Substance Regulation Law
• Board member of Health and Science Council, Ministry of Health, Labour and Welfare (2005- present)
• Board member, Japan Anti-Aging Medicine
• Board member, Japanese Society of Clinical Nutrition
• Board member, Japan Anti Oxidant Unit Study Group
• Editor, Clinical and Functional Nutriology
• Council, Asia Pacific J Clinical Nutrition
• (1993) WHO TOH Medal
• (1993) Award of Japan Medical Association
• (2000) Award from Japan Epidemiological Association
• (2014) Award of Contribution to Society from the Keio University Medical School
1. Watanabe S. Dietary therapy for the elderly. Nihon Ronen Igakkai Zasshi. 2014; 51(2): 138-140.
2. Tatsumi Y, Morimoto A, Deura K, Mizuno S, Ohno Y, Watanabe S. Effects of soybean product intake on fasting and postload hyperglycemia and type 2 diabetes in Japanese men with high body mass index: The Saku Study. J Diabetes Investig. 2013; 4(6): 626-633. doi: 10.1111/jdi.12100
3. Morimoto A, Tatsumi Y, Deura K, Mizuno S, Ohno Y, Watanabe S. Impact of cigarette smoking on impaired insulin secretion and insulin resistance in Japanese men: The Saku Study. J Diabetes Investig. 2013; 4(3): 274-280. doi: 10.1111/jdi.12019
4. Tatsumi Y, Ohno Y, Morimoto A, Nishigaki Y, Mizuno S, Watanabe S. Age differences in the risk of diabetes incidence according to body mass index level in Japanese women. Obes Res Clin Pract. 2013; 7(6): e455-e463. doi: 10.1016/j.orcp.2012.05.001
5. Tatsumi Y, Ohno Y, Morimoto A, Nishigaki Y, Mizuno S, Watanabe S. BMI percentile curves for Japanese men and women aged 20-79 years who underwent a health check-up in 1980 and 2005. Obes Res Clin Pract. 2013; 7(5): e401-e406. doi: 10.1016/j.orcp.2012.05.004
6. Morimoto A, Tatsumi Y, Deura K, Miyamatsu N, Noda M, Watanabe S. Impact of impaired insulin secretion and insulin resistance on the incidence of diabetes in a Japanese cohort. Diabetologia. 2013; 56(11): 2546-2547. doi: 10.1007/s00125-013-3068-9
7. Park J, Ishikawa-Takata K, Tanaka S, et al. The relationship of body composition to daily physical activity in free-living Japanese adult men. Br J Nutr. 2014; 111(1): 182-188. doi: 10.1017/S0007114513001918
8. Goto M, Goto A, Morita A, et al. Low-molecular-weight adiponectin and high-molecular-weight adiponectin levels in relation to diabetes. Obesity (Silver Spring). 2014; 22(2): 401-407. doi: 10.1002/oby.20553
9. Goto A, Morita A, Goto M, et al. Validity of diabetes self-reports in the Saku diabetes study. J Epidemiol. 2013; 23(4): 295-300. doi: 10.2188/jea.JE20120221
10. Morimoto A, Tatsumi Y, Deura K, et al. Impact of impaired insulin secretion and insulin resistance on the incidence of type 2 diabetes mellitus in a Japanese population: the Saku study. Diabetologia. 2013; 56(8): 1671-1679. doi: 10.1007/s00125-013-2932-y
11. Goto M, Morita A, Goto A, et al. Reduction in adiposity, β-cell function, insulin sensitivity, and cardiovascular risk factors: a prospective study among Japanese with obesity. PLoS One. 2013; 8(3): e57964. doi: 10.1371/journal.pone.0057964
12. Takezawa J, Yamada K, Miyachi M, et al. Preproghrelin gene polymorphisms in obese Japanese women. Minor homozygotes are light eaters, do not prefer protein or fat, and apparently have a poor appetite. Appetite. 2013; 63: 105-111. doi: 10.1016/j.appet.2012.12.006
13. Goto A, Morita A, Goto M, et al. Associations of sex hormone-binding globulin and testosterone with diabetes among men and women (the Saku Diabetes study): a case control study. Cardiovasc Diabetol. 2012; 11: 130. doi: 10.1186/1475-2840-11-130
14. Morimoto A, Ohno Y, Tatsumi Y, Mizuno S, Watanabe S. Effects of healthy dietary pattern and other lifestyle factors on incidence of diabetes in a rural Japanese population. Asia Pac J Clin Nutr. 2012; 21(4): 601-608.
15. Goto M, Morita A, Goto A, et al. Dietary glycemic index and glycemic load in relation to HbA1c in Japanese obese adults: a cross-sectional analysis of the Saku Control Obesity Program. Nutr Metab (Lond). 2012; 9(1): 79. doi: 10.1186/1743-7075-9-79
16. Tatsumi Y, Ohno Y, Morimoto A, Nishigaki Y, Mizuno S, Watanabe S. Lifestyle and the risk of diabetes mellitus in a Japanese population. J Behav Med. 2013; 36(3): 225-233. doi: doi: 10.1007/s10865-012-9427-z
17. Hirai T, Fujimine Y, Watanabe S, Nakano T. Distribution of polybrominated diphenyl ethers in Japanese autopsy tissue and body fluid samples. Environ Sci Pollut Res Int. 2012; 19(8): 3538-3546. doi: 10.1007/s11356-012-0915-z
18. Nakade M, Aiba N, Morita A, Miyachi M, Sasaki S, Watanabe S. What behaviors are important for successful weight maintenance? J Obes. 2012; 2012: 202037. doi: 10.1155/2012/202037
19. Morimoto A, Ohno Y, Tatsumi Y, Nishigaki Y, Maejima F, Mizuno S, Watanabe S. Impact of smoking cessation on incidence of diabetes mellitus among overweight or normal-weight Japanese men. Diabetes Res Clin Pract. 2012; 96(3): 407-413. doi: 10.1016/j.diabres.2012.03.007
20. Morimoto A, Ohno Y, Tatsumi Y, Nishigaki Y, Maejima F, Mizuno S, Watanabe S. Risk of smoking and body mass index for incidence of diabetes mellitus in a rural Japanese population. Prev Med. 2012; 54(5): 341-344. doi: 10.1016/j.ypmed.2012.02.016
21. Nakade M, Aiba N, Suda N, et al. Behavioral change during weight loss program and one-year follow-up: Saku Control Obesity Program (SCOP) in Japan. Asia Pac J Clin Nutr. 2012; 21(1): 22-34.
22. Miyake R, Ohkawara K, Ishikawa-Takata K, Morita A, Watanabe S, Tanaka S. Obese Japanese adults with type 2 diabetes have higher basal metabolic rates than non-diabetic adults. J Nutr Sci Vitaminol (Tokyo). 2011; 57(5): 348-354.
23. Park J, Ishikawa-Takata K, Tanaka S, et al. Relation of body composition to daily physical activity in free-living Japanese adult women. Br J Nutr. 2011; 106(7): 1117-1127. doi: 10.1017/S0007114511001358
24. Fujino Y, Tanabe N, Honjo K, et al. A prospective cohort study of neighborhood stress and ischemic heart disease in Japan: a multilevel analysis using the JACC study data. BMC Public Health. 2011; 11: 398. doi: 10.1186/1471-2458-11-398
25. Tanaka T, Morita A, Kato M, Congener-specific polychlorinated biphenyls and the prevalence of diabetes in the Saku Control Obesity Program (SCOP). Endocr J. 2011; 58(7): 589-596.
26. Fujino Y, Tanabe N, Honjo K, et al. Interest in health screening as a predictor of long-term overall mortality: multilevel analysis of a Japanese national cohort study. Prev Med. 2011; 52(1): 78-83. doi: 10.1016/j.ypmed.2010.10.012
27. Taku K, Lin N, Cai D, et al. Effects of soy isoflavone extract supplements on blood pressure in adult humans: systematic review and meta-analysis of randomized placebo-controlled trials. J Hypertens. 2010; 28(10): 1971-1982. doi: 10.1097/HJH.0b013e32833c6edb
28. Taku K, Melby MK, Kurzer MS, Mizuno S, Watanabe S, Ishimi Y. Effects of soy isoflavone supplements on bone turnover markers in menopausal women: systematic review and meta-analysis of randomized controlled trials. Bone. 2010; 47(2): 413-423. doi: 10.1016/j.bone.2010.05.001
29. Taku K, Melby MK, Takebayashi J, et al. Effect of soy isoflavone extract supplements on bone mineral density in menopausal women: meta-analysis of randomized controlled trials. Asia Pac J Clin Nutr. 2010; 19(1): 33-42.
30. Wahlqvist ML, Keatinge JD, Butler CD, et al. A Food in Health Security (FIHS) platform in the Asia-Pacific Region: the way forward. Asia Pac J Clin Nutr. 2009; 18(4): 688-702.
31. Watanabe S, Melby M, Aiba N. Food safety and food labeling from the viewpoint of the consumers. Asia Pac J Clin Nutr. 2009; 18(4): 532-537.
32. Takezawa J, Yamada K, Morita A, Aiba N, Watanabe S. Preproghrelin gene polymorphisms in obese Japanese: Association with diabetes mellitus in men and with metabolic syndrome parameters in women. Obes Res Clin Pract. 2009; 3(4): 179-191. doi: 10.1016/j.orcp.2009.04.003
33. Lee JK, Murakami A, Watanabe S, Ohigashi H. Suppressive properties of extracts from Japanese edible plants regarding nitric oxide generation. Asian Pac J Cancer Prev. 2009 10(2): 263-272.
34. Otaki N, Kimira M, Katsumata S, Uehara M, Watanabe S, Suzuki K. Distribution and major sources of flavonoid intakes in the middle-aged Japanese women. J Clin Biochem Nutr. 2009; 44(3): 231-238. doi: 10.3164/jcbn.08-231
35. Messina M, Watanabe S, Setchell KD. Report on the 8th International Symposium on the Role of Soy in Health Promotion and Chronic Disease Prevention and Treatment. J Nutr. 2009; 139(4): 796S-802S. doi: 10.3945/jn.108.104182
36. Taku K, Umegaki K, Ishimi Y, Watanabe S. Effects of extracted soy isoflavones alone on blood total and LDL cholesterol: Meta-analysis of randomized controlled trials. Ther Clin Risk Manag. 2008; 4(5): 1097-1103.
37. Ishiwata N, Melby MK, Mizuno S, Watanabe S. New equol supplement for relieving menopausal symptoms: randomized, placebo-controlled trial of Japanese women. Menopause. 2009; 16(1): 141-148. doi: 10.1097/gme.0b013e31818379fa
38. Melby MK, Utsugi M, Miyoshi M, Watanabe S. Overview of nutrition reference and dietary recommendations in Japan: application to nutrition policy in Asian countries. Asia Pac J Clin Nutr. 2008; 17 Suppl 2: 394-398.
39. Fujino Y, Mori M, Tamakoshi A, et al. A prospective study of educational background and breast cancer among Japanese women. Cancer Causes Control. 2008; 19(9): 931-937. doi: 10.1007/s10552-008-9154-5
40. Peñalvo JL, Adlercreutz H, Uehara M, Ristimaki A, Watanabe S. Lignan content of selected foods from Japan. J Agric Food Chem. 2008; 56(2): 401-409. doi: 10.1021/jf072695u
41. Taku K, Umegaki K, Sato Y, Taki Y, Endoh K, Watanabe S. Soy isoflavones lower serum total and LDL cholesterol in humans: a meta-analysis of 11 randomized controlled trials. Am J Clin Nutr. 2007; 85(4): 1148-1156. Erratum in: Am J Clin Nutr. 2007; 86(3): 809.
42. Iida T, Todaka T, Hirakawa H, et al. Concentration and distribution of dioxins and related compounds in human tissues. Chemosphere. 2007; 67(9): S263-S271.
43. Melby MK, Watanabe S, Whitten PL, Worthman CM. Sensitive high-performance liquid chromatographic method using coulometric electrode array detection for measurement of phytoestrogens in dried blood spots. J Chromatogr B Analyt Technol Biomed Life Sci. 2005; 826(1-2): 81-90.
44. Hosoi S, Honma K, Daimatsu T, Kiyokawa M, Aikawa T, Watanabe S. Lower energy content of human milk than calculated using conversion factors. Pediatr Int. 2005; 47(1): 7-9.
45. Ouchi K, Gamache P, Acworth I, Watanabe S. Measurement of isoflavones using liquid chromatography with multi-channel coulometric electrochemical detection. Biofactors. 2004; 22(1-4): 353-356.
46. Zhuo XG, Watanabe S. The construction of web database server-client system for functional food factors. Biofactors. 2004; 22(1-4): 329-332.
47. Murashima M, Watanabe S, Zhuo XG, Uehara M, Kurashige A. Phase 1 study of multiple biomarkers for metabolism and oxidative stress after one-week intake of broccoli sprouts. Biofactors. 2004; 22(1-4): 271-275.
48. Melby MK, Murashima M, Watanabe S. Phytochemical intake and relationship to past health history in Japanese women. Biofactors. 2004; 22(1-4): 265-269.
49. Kita J, Tada J, Ito M, et al. Intake of phytochemicals among Japanese, calculated by the new FFF database. Biofactors. 2004; 22(1-4): 259-263.
50. Uesugi S, Watanabe S, Ishiwata N, Uehara M, Ouchi K. Effects of isoflavone supplements on bone metabolic markers and climacteric symptoms in Japanese women. Biofactors. 2004; 22(1-4): 221-228.
51. Watanabe S, Zhuo XG, Kimira M. Food safety and epidemiology: new database of functional food factors. Biofactors. 2004; 22(1-4): 213-219.
52. Takachi R, Kimira M, Uesugi S, Kudo Y, Ouchi K, Watanabe S. The effect of dietary and plasma fatty acids on platelet aggregation in senior generation of Japanese women. Biofactors. 2004; 22(1-4): 205-210.
53. Haba R, Watanabe S, Wada M, Udaka S. Effects of lactoferrin, soya germ and polyamine on 2-amino-1-methyl-6- phenylimidazo[4,5-b]-pyridine(PhIP)- induced breast carcinogenesis in rats. Biofactors. 2004; 22(1-4): 127-131.
54. Ono M, Munakata N, Watanabe S. UV exposure of elementary school children in five Japanese cities. Photochem Photobiol. 2005; 81(2): 437-445.
55. Zhuo XG, Melby MK, Watanabe S. Soy isoflavone intake lowers serum LDL cholesterol: a meta-analysis of 8 randomized controlled trials in humans. J Nutr. 2004; 134(9): 2395-2400.
56. Murashima M, Kikuchi Y, Nomiyama T, et al. [Intake and excretion of cadmium and iron balance and influence of dietary habits among young women]. Nihon Eiseigaku Zasshi. 2004; 59(1): 31-37.
57. Kimira M, Kudo Y, Takachi R, Haba R, Watanabe S. [Associations between dietary intake and urinary excretion of sodium, potassium, phosphorus, magnesium, and calcium]. Nihon Eiseigaku Zasshi. 2004; 59(1): 23-30.
58. Kikuchi Y, Nomiyama T, Kumagai N, et al. Uptake of cadmium in meals from the digestive tract of young non-smoking Japanese female volunteers. J Occup Health. 2003; 45(1): 43-52.
59. Watanabe S, Uesugi S, Zhuo X, Kimira M. [Phytoestrogen and cancer prevention]. Gan To Kagaku Ryoho. 2003; 30(7): 902-908.
60. Toide K, Yamazaki H, Nagashima R, et al. Aryl hydrocarbon hydroxylase represents CYP1B1, and not CYP1A1, in human freshly isolated white cells: trimodal distribution of Japanese population according to induction of CYP1B1 mRNA by environmental dioxins. Cancer Epidemiol Biomarkers Prev. 2003; 12(3): 219-222.
61. Ouchi K, Watanabe S. Measurement of bisphenol A in human urine using liquid chromatography with multi-channel coulometric electrochemical detection. J Chromatogr B Analyt Technol Biomed Life Sci. 2002; 780(2): 365-370.
62. Watanabe S, Uesugi S, Kikuchi Y. Isoflavones for prevention of cancer, cardiovascular diseases, gynecological problems and possible immune potentiation. Biomed Pharmacother. 2002; 56(6): 302-312.
63. Haba R, Watanabe S, Arai Y, Chiba H, Miura T. Suppression of lipid-hydroperoxide and DNA-adduct formation by isoflavone-containing soy hypocotyl tea in rats. Environ Health Prev Med. 2002; 7(2): 64-73. doi: 10.1007/BF02897332
64. Watanabe S. Current controversies around carbohydrate restriction and the risk of high-protein diets. Diabetes Res Open J. 2015; 1(5): e7-e10. doi: 10.17140/DROJ-1-e003
65. Kawashima N, Watanabe S, Morita A, Aiba N, Miyachi M, Sakai T. Changes of fat volume and adipocytokines by the randomized intervention program for obesity control program (SCOP). Diabetes Res Open J. 2015; 1(5): 136-146. doi: 10.17140/ DROJ-1-122